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Conserved domains on  [gi|74048573|ref|NP_001027564|]
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plasminogen-like protein B precursor [Homo sapiens]

Protein Classification

PAN/Apple domain-containing protein( domain architecture ID 10099731)

PAN/Apple domain-containing protein similar to Homo sapiens plasminogen-like proteins A and B, which may bind noncovalently to lysine binding sites present in the kringle structures of plasminogen

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 22-96 4.41e-15

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


:

Pssm-ID: 238532  Cd Length: 80  Bit Score: 64.03  E-value: 4.41e-15
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74048573 22 LDDYVNTQGPSLFSVT--KKQLGAGSREECAAKCEEDKEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRD--AVLFEK 96
Cdd:cd01099  1 LNDFKFVLVLNKILVSevKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDsnVDYYEN 79
 
Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 22-96 4.41e-15

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 64.03  E-value: 4.41e-15
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74048573 22 LDDYVNTQGPSLFSVT--KKQLGAGSREECAAKCEEDKEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRD--AVLFEK 96
Cdd:cd01099  1 LNDFKFVLVLNKILVSevKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDsnVDYYEN 79
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 24-96 3.55e-12

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 56.41  E-value: 3.55e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74048573   24 DYVNTQGPSLFSVTKKQLGAGSREECAAKCEEDKefTCRAFQYHSKEQQCVIMAENRKS--SIIIRMRDAVLFEK 96
Cdd:pfam00024  2 DFERVPGSSLSGVDVSTVTVSSAEECAQRCTNEP--RCRSFTYNPKSKKCHLKSSSSGSlpRLKRSDNKVDYYEK 74
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 23-96 3.58e-12

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 56.43  E-value: 3.58e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74048573    23 DDYVNTQGPSLFSVTKKQLGAGSREECAAKCEEDKeFTCRAFQYHSKEQQCVIMAENRKSSI-IIRMRDAVLFEK 96
Cdd:smart00473  4 DCFVRLPNTKLPGFSRIVISVASLEECASKCLNSN-CSCRSFTYNNGTKGCLLWSESSLGDArLFPSGGVDLYEK 77
 
Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 22-96 4.41e-15

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 64.03  E-value: 4.41e-15
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74048573 22 LDDYVNTQGPSLFSVT--KKQLGAGSREECAAKCEEDKEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRD--AVLFEK 96
Cdd:cd01099  1 LNDFKFVLVLNKILVSevKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDsnVDYYEN 79
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 24-96 3.55e-12

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 56.41  E-value: 3.55e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74048573   24 DYVNTQGPSLFSVTKKQLGAGSREECAAKCEEDKefTCRAFQYHSKEQQCVIMAENRKS--SIIIRMRDAVLFEK 96
Cdd:pfam00024  2 DFERVPGSSLSGVDVSTVTVSSAEECAQRCTNEP--RCRSFTYNPKSKKCHLKSSSSGSlpRLKRSDNKVDYYEK 74
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 23-96 3.58e-12

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 56.43  E-value: 3.58e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74048573    23 DDYVNTQGPSLFSVTKKQLGAGSREECAAKCEEDKeFTCRAFQYHSKEQQCVIMAENRKSSI-IIRMRDAVLFEK 96
Cdd:smart00473  4 DCFVRLPNTKLPGFSRIVISVASLEECASKCLNSN-CSCRSFTYNNGTKGCLLWSESSLGDArLFPSGGVDLYEK 77
PAN_APPLE cd00129
PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth ...
 43-79 6.51e-03

PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech anti-platelet proteins. Common structural features include two disulfide bonds that link the alpha-helix to the central region of the protein. PAN domains have significant functional versatility, fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238074  Cd Length: 80  Bit Score: 32.67  E-value: 6.51e-03
                       10        20        30
               ....*....|....*....|....*....|....*...
gi 74048573 43 AGSREECAAKCEEDK-EFTCRAFQYHSKEQQCVIMAEN 79
Cdd:cd00129 24 ANTADECANRCEKNGlPFSCKAFVFAKARKQCLWFPFN 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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