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Conserved domains on  [gi|115511062|ref|NP_001028644|]
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BCLAF1 and THRAP3 family member 3 isoform 1 [Mus musculus]

Protein Classification

BCLAF1 and THRAP3 family protein( domain architecture ID 12173452)

BCLAF1 and THRAP3 family protein is an RNA processing factor that plays critical roles in maintaining DNA genomic stability, such as the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1) and thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 2-667 0e+00

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


:

Pssm-ID: 464718  Cd Length: 641  Bit Score: 573.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062    2 ARSRSRSPrwKQRSLSPQSRNFEYHEERHFHG----HYDPEYRH---DQQRPFTWRMDDEKHGQNKPRIPPRVNSYHRSY 74
Cdd:pfam15440   1 GRSRSRSP--KRRSLSPRSRSRSHYSDRSSSGrsrsSSSRSSSNhskDPKRSKRWRMDDKKHGQKDPRISPHGNDHNRSY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062   75 VNRSP-----------SPNVK-PVEKFDTYKPHQEYFPGRGDDDRRSQYMPTYTESAATymeherdCYIPTVQGRYTPDD 142
Cdd:pfam15440  79 EHRSPdaksseaskswSPKRRsPLESVYVYKPSPRPSPERGDSSRRDQYMPKPSEPSPY-------QYSPKQQGRYHGRG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  143 HRGrgrgsgrgekppqmslgkppkMSLGKPPQMSLADSLRFKEKWHEDELRHQrvqeesypQSPRRGSEDFGTRNPFQKR 222
Cdd:pfam15440 152 RGS---------------------PKGGSPPRRSPADSFSFEGKWHEDELRHQ--------QSPRRGSEEFSARSSFQKR 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  223 YPEDHDFRKYGYTSKRPTD----AARYENRDPARIPKWKPEHSFLPFQEKKEEWSFGAQGHRYTEREYPErssttrvSYD 298
Cdd:pfam15440 203 YPEEQDFRKYGHTSERGKEkeqkDARYEKREPARNSKWKDEHSLPPYQEKDDQRNKGPQSSRYAERESPE-------SYD 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  299 YRHKHHK-LSESEQDFPDGRFHKHLKEEDRKYSSIKAPANRELDCFSTTRGREIENEQINGPF-YLYNKNSVSYNHTNIK 376
Cdd:pfam15440 276 YRHKFEKkLAEFEKDFSDGRTEKYEKEDRKKFSSKISKGNRESDCFSEGRGRKTEEGQVEPSAkEKSKKDEIACTDSMEN 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  377 DADLEPCNDKWKKKISKE-DCRKE-NASFSKQFDTSPKPEEKCYSLIK-----KKPLSVKVDRNKT--DTFRSTSRYSAE 447
Cdd:pfam15440 356 DVYLERFNDKKEEKSKKEgDFRKEaELSSSSQHDDSREKPDVKESSPKsvfsiKRESTVKVDMDKFdeDLARPSSSLAQE 435

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  448 RQISHDLVAIGKTSDNFHPVFQHLDStQNPENKPTEEFAQEIITLIHKVKADSFVTPDITLNERFSRIKNRQdADFNQTK 527
Cdd:pfam15440 436 RQLSRDLVHSGKKDQEFRSIFEHIQS-QQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRA-AEQEEMK 513

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  528 SNSDPEFHRRIDMSLDDFQNKYTMVYEPDKTLV------KVIE-PNDLRHDIERRRKERLQNEDENIFHMaspteRNHQS 600
Cdd:pfam15440 514 SNKSPEIHRRIDMSPSALRKHRTLFEESKQSKEssykegKVKEdPNDLRHDIERRRKERLKERDEKRFHI-----RDSQD 588

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115511062  601 PSFSKVKTIRADGFQKPPHFIKSNFRKfiqkpyinyTMQRKDaidqkIFRVEENHQNRRGSKGSFKN 667
Cdd:pfam15440 589 SRFSSLSRERTEKFQKPHKFSKKNFRT---------SKKRRD-----RITISRSSSNSSSSSRSFKA 641
 
Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 2-667 0e+00

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


Pssm-ID: 464718  Cd Length: 641  Bit Score: 573.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062    2 ARSRSRSPrwKQRSLSPQSRNFEYHEERHFHG----HYDPEYRH---DQQRPFTWRMDDEKHGQNKPRIPPRVNSYHRSY 74
Cdd:pfam15440   1 GRSRSRSP--KRRSLSPRSRSRSHYSDRSSSGrsrsSSSRSSSNhskDPKRSKRWRMDDKKHGQKDPRISPHGNDHNRSY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062   75 VNRSP-----------SPNVK-PVEKFDTYKPHQEYFPGRGDDDRRSQYMPTYTESAATymeherdCYIPTVQGRYTPDD 142
Cdd:pfam15440  79 EHRSPdaksseaskswSPKRRsPLESVYVYKPSPRPSPERGDSSRRDQYMPKPSEPSPY-------QYSPKQQGRYHGRG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  143 HRGrgrgsgrgekppqmslgkppkMSLGKPPQMSLADSLRFKEKWHEDELRHQrvqeesypQSPRRGSEDFGTRNPFQKR 222
Cdd:pfam15440 152 RGS---------------------PKGGSPPRRSPADSFSFEGKWHEDELRHQ--------QSPRRGSEEFSARSSFQKR 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  223 YPEDHDFRKYGYTSKRPTD----AARYENRDPARIPKWKPEHSFLPFQEKKEEWSFGAQGHRYTEREYPErssttrvSYD 298
Cdd:pfam15440 203 YPEEQDFRKYGHTSERGKEkeqkDARYEKREPARNSKWKDEHSLPPYQEKDDQRNKGPQSSRYAERESPE-------SYD 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  299 YRHKHHK-LSESEQDFPDGRFHKHLKEEDRKYSSIKAPANRELDCFSTTRGREIENEQINGPF-YLYNKNSVSYNHTNIK 376
Cdd:pfam15440 276 YRHKFEKkLAEFEKDFSDGRTEKYEKEDRKKFSSKISKGNRESDCFSEGRGRKTEEGQVEPSAkEKSKKDEIACTDSMEN 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  377 DADLEPCNDKWKKKISKE-DCRKE-NASFSKQFDTSPKPEEKCYSLIK-----KKPLSVKVDRNKT--DTFRSTSRYSAE 447
Cdd:pfam15440 356 DVYLERFNDKKEEKSKKEgDFRKEaELSSSSQHDDSREKPDVKESSPKsvfsiKRESTVKVDMDKFdeDLARPSSSLAQE 435

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  448 RQISHDLVAIGKTSDNFHPVFQHLDStQNPENKPTEEFAQEIITLIHKVKADSFVTPDITLNERFSRIKNRQdADFNQTK 527
Cdd:pfam15440 436 RQLSRDLVHSGKKDQEFRSIFEHIQS-QQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRA-AEQEEMK 513

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  528 SNSDPEFHRRIDMSLDDFQNKYTMVYEPDKTLV------KVIE-PNDLRHDIERRRKERLQNEDENIFHMaspteRNHQS 600
Cdd:pfam15440 514 SNKSPEIHRRIDMSPSALRKHRTLFEESKQSKEssykegKVKEdPNDLRHDIERRRKERLKERDEKRFHI-----RDSQD 588

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115511062  601 PSFSKVKTIRADGFQKPPHFIKSNFRKfiqkpyinyTMQRKDaidqkIFRVEENHQNRRGSKGSFKN 667
Cdd:pfam15440 589 SRFSSLSRERTEKFQKPHKFSKKNFRT---------SKKRRD-----RITISRSSSNSSSSSRSFKA 641
 
Name Accession Description Interval E-value
THRAP3_BCLAF1 pfam15440
THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 ...
 2-667 0e+00

THRAP3/BCLAF1 family; This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).


Pssm-ID: 464718  Cd Length: 641  Bit Score: 573.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062    2 ARSRSRSPrwKQRSLSPQSRNFEYHEERHFHG----HYDPEYRH---DQQRPFTWRMDDEKHGQNKPRIPPRVNSYHRSY 74
Cdd:pfam15440   1 GRSRSRSP--KRRSLSPRSRSRSHYSDRSSSGrsrsSSSRSSSNhskDPKRSKRWRMDDKKHGQKDPRISPHGNDHNRSY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062   75 VNRSP-----------SPNVK-PVEKFDTYKPHQEYFPGRGDDDRRSQYMPTYTESAATymeherdCYIPTVQGRYTPDD 142
Cdd:pfam15440  79 EHRSPdaksseaskswSPKRRsPLESVYVYKPSPRPSPERGDSSRRDQYMPKPSEPSPY-------QYSPKQQGRYHGRG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  143 HRGrgrgsgrgekppqmslgkppkMSLGKPPQMSLADSLRFKEKWHEDELRHQrvqeesypQSPRRGSEDFGTRNPFQKR 222
Cdd:pfam15440 152 RGS---------------------PKGGSPPRRSPADSFSFEGKWHEDELRHQ--------QSPRRGSEEFSARSSFQKR 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  223 YPEDHDFRKYGYTSKRPTD----AARYENRDPARIPKWKPEHSFLPFQEKKEEWSFGAQGHRYTEREYPErssttrvSYD 298
Cdd:pfam15440 203 YPEEQDFRKYGHTSERGKEkeqkDARYEKREPARNSKWKDEHSLPPYQEKDDQRNKGPQSSRYAERESPE-------SYD 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  299 YRHKHHK-LSESEQDFPDGRFHKHLKEEDRKYSSIKAPANRELDCFSTTRGREIENEQINGPF-YLYNKNSVSYNHTNIK 376
Cdd:pfam15440 276 YRHKFEKkLAEFEKDFSDGRTEKYEKEDRKKFSSKISKGNRESDCFSEGRGRKTEEGQVEPSAkEKSKKDEIACTDSMEN 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  377 DADLEPCNDKWKKKISKE-DCRKE-NASFSKQFDTSPKPEEKCYSLIK-----KKPLSVKVDRNKT--DTFRSTSRYSAE 447
Cdd:pfam15440 356 DVYLERFNDKKEEKSKKEgDFRKEaELSSSSQHDDSREKPDVKESSPKsvfsiKRESTVKVDMDKFdeDLARPSSSLAQE 435

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  448 RQISHDLVAIGKTSDNFHPVFQHLDStQNPENKPTEEFAQEIITLIHKVKADSFVTPDITLNERFSRIKNRQdADFNQTK 527
Cdd:pfam15440 436 RQLSRDLVHSGKKDQEFRSIFEHIQS-QQSERSPSEEFAQHIVTIVHHVKAHYFPSSGMTLHERFSKYQKRA-AEQEEMK 513

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511062  528 SNSDPEFHRRIDMSLDDFQNKYTMVYEPDKTLV------KVIE-PNDLRHDIERRRKERLQNEDENIFHMaspteRNHQS 600
Cdd:pfam15440 514 SNKSPEIHRRIDMSPSALRKHRTLFEESKQSKEssykegKVKEdPNDLRHDIERRRKERLKERDEKRFHI-----RDSQD 588

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115511062  601 PSFSKVKTIRADGFQKPPHFIKSNFRKfiqkpyinyTMQRKDaidqkIFRVEENHQNRRGSKGSFKN 667
Cdd:pfam15440 589 SRFSSLSRERTEKFQKPHKFSKKNFRT---------SKKRRD-----RITISRSSSNSSSSSRSFKA 641
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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