|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
43-477 |
0e+00 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 525.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 43 EAAALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTGISVGTGLASACDTLMSQSFGGKNLKRVG 122
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 123 VILQRGILILLLCCFPCWAIFLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIA 202
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 203 ANVVNVGMNAFLLYALDLGVVGSAWANTTSQFFLSALLFLYVWWKRIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCIE 282
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 283 WWTFEIGTFLAG-LVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALLVGI 361
Cdd:cd13132 241 WWAFEILVLLAGlLPGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 362 LLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIGVSLMFAAK 441
Cdd:cd13132 321 LLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVLG 400
|
410 420 430
....*....|....*....|....*....|....*.
gi 85702045 442 LGIIGLWAGLIVCVSFQAFSYLIYILRTNWSRVAEQ 477
Cdd:cd13132 401 LGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
43-468 |
1.47e-73 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 241.25 E-value: 1.47e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 43 EAAALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVG 122
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 123 VILQRGILILLLCCFPCWAIFLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIA 202
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 203 ANVVNVGMNAFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVWWKRI--HIHTWGGWTRECFQEWSSYTRLAIPSM 276
Cdd:cd13131 160 ALVLNIPLNYVLIFGKfglpALGGAGAGLATAIVYWLMFLALAFYIRRHKRfrRYRLFARFWRPDWARLKELLRLGLPIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 277 FMVCIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCA 356
Cdd:cd13131 240 LTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 357 LLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIGVSL 436
Cdd:cd13131 320 ALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLGYLL 399
|
410 420 430
....*....|....*....|....*....|..
gi 85702045 437 MFAAKLGIIGLWAGLIVCVSFQAFSYLIYILR 468
Cdd:cd13131 400 AFTTGLGAFGVWIGLIIGLALAAILLLWRFRR 431
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
46-465 |
9.47e-70 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 230.80 E-value: 9.47e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 46 ALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVIL 125
Cdd:COG0534 9 LLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 126 QRGILILLLCCFPCWAI-FLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAAN 204
Cdd:COG0534 88 GQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 205 VVNVGMNAFLLYALDLGVVGSAWANTTSQFFLSALLFLYVWWKRIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCIEWW 284
Cdd:COG0534 168 VLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAESL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 285 TFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALLVGILLA 364
Cdd:COG0534 248 GFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLF 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 365 ALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIGVsLMFAAKLGI 444
Cdd:COG0534 328 LFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAY-LLAFLGLGL 406
|
410 420
....*....|....*....|.
gi 85702045 445 IGLWAGLIVCVSFQAFSYLIY 465
Cdd:COG0534 407 TGVWLALPIGEVLRALLLLLR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
53-392 |
3.54e-58 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 197.85 E-value: 3.54e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 53 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAvSVVNVTGISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILIL 132
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 133 LLCCFPCWAIFLNTERLLLLLRQ-DPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 211
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 212 AFLLYAL--DLGVVGSAWANTTSQFFLSALLFLYVWWKRIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCIEWWTFEIG 289
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 290 TFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALLVGILLAALKDV 369
Cdd:TIGR00797 240 ALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREF 319
|
330 340
....*....|....*....|...
gi 85702045 370 VAYIFTNDKDIISLVSQVMPIFA 392
Cdd:TIGR00797 320 IARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
46-471 |
3.15e-53 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 186.95 E-value: 3.15e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 46 ALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVIL 125
Cdd:cd13137 2 RIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 126 QRGILILLLCCFP-CWAIFLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAAN 204
Cdd:cd13137 81 GQSLLLALLLSLPlALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 205 VVNVGMNAFLLYAL----DLGVVGSAWANTTSQFFlSALLFLYVWWK-RIHIHTWGGWTRECFQEWSSYTRLAIPSMFMV 279
Cdd:cd13137 161 VLNIVLDYVLIFGLwgfpGLGVAGAALATVISRVV-GALLLLFLLLRgRLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 280 CIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALLV 359
Cdd:cd13137 240 LLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 360 GILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIGVSLMFA 439
Cdd:cd13137 320 GLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGFV 399
|
410 420 430
....*....|....*....|....*....|..
gi 85702045 440 AKLGIIGLWAGLIVCVSFQAFSYLIYILRTNW 471
Cdd:cd13137 400 LGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
51-467 |
3.17e-53 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 186.76 E-value: 3.17e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 51 AGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNvTGISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGIL 130
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIA-LLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 131 ILLLCCFPCWAIFL-NTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVG 209
Cdd:cd12082 80 LAILLGLLLAALLLfFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 210 MNAFLLY---ALDLGVVGSAWANTTSQFFLSALLFLYVWWKRIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCIEWWTF 286
Cdd:cd12082 160 LDPLLIFglgPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 287 EIGTFLAGLVN-VTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALLVGILLAA 365
Cdd:cd12082 240 LIIVAIVAAFGgAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 366 LKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIGVsLMFAAKLGII 445
Cdd:cd12082 320 FPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAY-VLAYLGLGLY 398
|
410 420
....*....|....*....|..
gi 85702045 446 GLWAGLIVCVSFQAFSYLIYIL 467
Cdd:cd12082 399 GIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-471 |
7.71e-53 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 186.19 E-value: 7.71e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 47 LVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAvSVVNVTGISVGTGLASACDTLMSQSFGGKNLKRVGVILQ 126
Cdd:cd13133 7 ILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 127 RGILILLLCCFPCWAI-FLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANV 205
Cdd:cd13133 86 QGLYFSLLLAPLLALLsALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 206 VNVGMNAFLLY----ALDLGVVGSAWANTTSQFFLSALLFLYVWWKRIH--IHTWGGWtRECFQEWSSYTRLAIPSMFMV 279
Cdd:cd13133 166 VNIVLDYALIFgklgFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRrrFGLRRAW-RFDRELLRRILRLGLPSGLQF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 280 CIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALLV 359
Cdd:cd13133 245 FLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLLL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 360 GILLAALKDVVAYIFTNDKD---IISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIGVsL 436
Cdd:cd13133 325 GILFLLFPELLLSIFTPGADfalIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPAY-L 403
|
410 420 430
....*....|....*....|....*....|....*
gi 85702045 437 MFAAKLGIIGLWAGLIVCVSFQAFSYLIYILRTNW 471
Cdd:cd13133 404 LVVLGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
41-482 |
2.24e-46 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 169.22 E-value: 2.24e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 41 RREAAALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVnVTGISVGTGLASACDTLMSQSFGGKNLKR 120
Cdd:PRK01766 8 KSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIW-LPVILFGHGLLLALTPIVAQLNGAGRRER 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 121 VGVILQRGILILLLCCFPCWAIFLNTERLLLLLRQ-DPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIV 199
Cdd:PRK01766 87 IAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNlEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 200 GIAANVVNVGMNAFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVWWKR--IHIHTWGGWTRECFQEWSSYTRLAI 273
Cdd:PRK01766 167 GFLGLLINIPLNYIFIYGKfgfpELGGVGCGVATAIVYWVMFLAMLIYIKRARrfRDFRLFKGLYKPDWAVIKRLLKLGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 274 PSMFMVCIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAG 353
Cdd:PRK01766 247 PIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLAVGL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 354 VCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIG 433
Cdd:PRK01766 327 GMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGLPLG 406
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 85702045 434 VSLMFAAKLGIIGLWAGLIVCVSFQAFSYLIYILRTnWSRVAEQAQVRA 482
Cdd:PRK01766 407 YILALTDPMGPFGFWIGLIIGLTAAAILLLLRLRKL-QRQPSAIILQRA 454
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
46-471 |
1.94e-37 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 143.75 E-value: 1.94e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 46 ALVALAGPVFLAQLMIFLISIVSSIFCGH-LGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRV--- 121
Cdd:cd13138 4 TLLLFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFLL-TAIGMGLSMGGTILISQYIGAKDEEKAkka 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 122 -------GVILQRGILILLLCCFPCWAIFLNTerlllllrqDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQG-II 193
Cdd:cd13138 83 vgtllvlFLILGIVLTILGLLFAPPILRLMNT---------PAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGdSK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 194 MPQVIVGIAAnVVNVGMNAFLLYALDLGVVGSAWANTTSQFFLSALLFLYVWWKRIHIHtwggWTRECF----QEWSSYT 269
Cdd:cd13138 154 TPLYFVIIAC-VLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFK----LSLKDFrfdkEILKEIL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 270 RLAIPSMFMVCIewwtFEIG-TFLAGLVN---VTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSC 345
Cdd:cd13138 229 KIGLPSALQQSL----VSISfLIINSIVNsygVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 346 TTVLLCAGVCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGY 425
Cdd:cd13138 305 RTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRL 384
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 85702045 426 YGFGFPIGVSLMFAAKLGIIGLWAGLIVCVSFQAFSYLIYILRTNW 471
Cdd:cd13138 385 WLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRW 430
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-471 |
5.72e-37 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 142.64 E-value: 5.72e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 47 LVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVtGISVGTGLASACDTLMSQSFGGKNLKRVGVILQ 126
Cdd:cd13134 5 LFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFL-LILIFSFISTGTSILIAQYLGAKDKKKARQIAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 127 RGILI---------LLLCCFPC-WAIFLNTerlllllrqDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQ 196
Cdd:cd13134 84 VALLFnlllglvfsLLLLFFGAeLLRLMGL---------PPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 197 VIVGIAANVVNVGMNAFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVW---WKRIHIHTWGGWTRECFQEwssYT 269
Cdd:cd13134 155 MYVSLIMNILNIVGNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLFrklKIRFRLKDLRPFPKKLLKK---IL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 270 RLAIPS--------MFMVCIewwtfeigTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQA 341
Cdd:cd13134 232 KIGLPSageelsynLSQTVI--------TAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 342 RCSCTTVLLCAGVCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLN 421
Cdd:cd13134 304 YKRVLKSLKIGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIG 383
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 85702045 422 TIGYYGFGFPIGVSLMFAAKLGIIGLWAGLIVCVSFQAFSYLIYILRTNW 471
Cdd:cd13134 384 IISMWGISVPLAYLLGIVLGLGLLGVWIAFAADEWVRGIIMLWRWRSGKW 433
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
45-468 |
8.40e-36 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 138.85 E-value: 8.40e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 45 AALVALAGPVFLAQLMIFLISIVSSIFCGHLGK-VELDAVTLAVSVVNVtgISVGTG-LASACDTLMSQSFGGKNLKRVG 122
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLGSaAYLGAVALGTTIFNT--LFWLFGfLRMGTTGLVAQALGAGDREEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 123 VILQRGILI-----LLLCCFPCWAIFLnterLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQV 197
Cdd:cd13136 81 ALLVRALLLalaigLLLILLQSPLLAL----ALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 198 IVGIAANVVNVGMNAFLLYALDLGVVGSAWANTTSQFfLSALLFLYVWWKRIHIHTWGGWTR-ECFQEWSSYTRLAIPSM 276
Cdd:cd13136 157 ILQIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQY-LGALLGLWLLRRRVRLLGKSLSRRlPSKAALKRLFKLNRDIF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 277 FMVCIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCA 356
Cdd:cd13136 236 IRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 357 LLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGkqKIGAVLNTIGYYGFGFpIGVSL 436
Cdd:cd13136 316 VLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGAT--DTRYLRNSMLVSLAVF-LPLLF 392
|
410 420 430
....*....|....*....|....*....|..
gi 85702045 437 MFAAKLGIIGLWAGLIVCVSFQAFSYLIYILR 468
Cdd:cd13136 393 LLVPLWGNHGLWLALILFMLLRGLTLALRLPR 424
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-473 |
5.20e-29 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 119.60 E-value: 5.20e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 46 ALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVnVTGISVGTGLASACDTLMSQSFGGKNLKRVGVIL 125
Cdd:cd13142 12 TLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLI-FLFISLGGGLTVAGTALVAQYTGAGDYDKANKVA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 126 QRGILILLLCCFPCWAI--FLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQG-IIMPQVIVGIA 202
Cdd:cd13142 91 GQTFSFVIILSLILAVLgyILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGdTKTPMKIMFGS 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 203 AnVVNVGMNAFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVWWKRIHIHTWggwTRECFQEWSSYT---RLAIPS 275
Cdd:cd13142 171 V-LLNVILDPLLIFGIgpfpGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKIS---LRDLKPDWEWLKkifRIGLPS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 276 MFMVCIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVC 355
Cdd:cd13142 247 SIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLI 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 356 ALLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIGVS 435
Cdd:cd13142 327 LVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYL 406
|
410 420 430
....*....|....*....|....*....|....*...
gi 85702045 436 LMFAAKLGIIGLWAGLIVCVSFQAFSYLIYILRTNWSR 473
Cdd:cd13142 407 LAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWKK 444
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
46-448 |
2.75e-27 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 114.53 E-value: 2.75e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 46 ALVALAGPVFLAQLMIFLISIVSSIFCGHL-GKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVI 124
Cdd:cd13143 5 LFLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMLL-MALGLMIGVGGASLISRRLGAGDREKANRI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 125 LQRGI-LILLLCCFPCWAIFLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAA 203
Cdd:cd13143 84 FSTALlLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 204 NVVNVGMNAFLLYALDLGVVGSAWANTTSQFFLSALLFLYVWWKRIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCiew 283
Cdd:cd13143 164 AVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPSFLMQL--- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 284 wTFEIGTF-----LAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALL 358
Cdd:cd13143 241 -SSSVVTIvlnltLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 359 VGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGyyGFGFPIGVSLMF 438
Cdd:cd13143 320 LFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLR--QGLFLIPLLLIL 397
|
410
....*....|
gi 85702045 439 AAKLGIIGLW 448
Cdd:cd13143 398 PRLFGLDGIW 407
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
44-448 |
3.16e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 105.30 E-value: 3.16e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 44 AAALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAV---------TLAVSVVNVTGISVGTglasacdtlmSQSFG 114
Cdd:cd13140 4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVgtagffvwlAYALALLSKIGAQVKV----------SQSIG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 115 GKNLKRVGVILQRGILILLLCCFpCWAIFL---NTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQG 191
Cdd:cd13140 74 AKDEKEARKYARNALQLNLLLGI-LYGLLLllfAKPLIGFFNLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 192 IIMPQVIVGIAANVVNVGMNAFLLYALD----LGVVGSAWANTTSQFFLSALLFLYVWWKRIHIHTWGGWTRECFQEWSS 267
Cdd:cd13140 153 DSKTPFIINAIGLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 268 YTRLAIPSMFMVCIewWTFeIGTFLAGLVNV---TELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCS 344
Cdd:cd13140 233 ILKLGLPVALQSIL--FAL-ISMILARIIASfgpVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 345 CTTVLLCAGVCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIG 424
Cdd:cd13140 310 YKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISIVF 389
|
410 420
....*....|....*....|....
gi 85702045 425 yYGFGFPIGVSLMFAAkLGIIGLW 448
Cdd:cd13140 390 -NGLRIPLALLLSPTG-LGLNGIW 411
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-413 |
3.53e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 105.39 E-value: 3.53e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 47 LVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVILQ 126
Cdd:cd13144 10 LLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKEANKAAN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 127 RGI-LILLLCCFPCWAIFLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANV 205
Cdd:cd13144 89 NGLlLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 206 VNVGMNAFLLYAL----DLGVVGSAWANTTSQfFLSALLFLYVWWKRIHIHTWG-GWTRECFQEWSSYTRLAIPSMFMVC 280
Cdd:cd13144 169 INIILDPILIFGLfgfpAMGIAGAAIATVIGQ-ILAMFLAFFFLLRKNKDVQPDlRLFRPSLRIIKEIYAVGLPSIIMQA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 281 iewwtfeIGTFLAGLVN-------VTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAG 353
Cdd:cd13144 248 -------ISSVMVFGLNkilagfgPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 354 VCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGK 413
Cdd:cd13144 321 VIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGR 380
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
53-211 |
9.45e-24 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 97.64 E-value: 9.45e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 53 PVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILIL 132
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 133 LLCCFP-CWAIFLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMN 211
Cdd:pfam01554 80 LLLSLPiALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
274-433 |
6.37e-23 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 95.32 E-value: 6.37e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 274 PSMFMVCIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAG 353
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 354 VCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGyYGFGFPIG 433
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPLN 159
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
36-451 |
2.45e-20 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 94.04 E-value: 2.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 36 LSPDVRREAAALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTGISVgTGLASACDTLMSQSFGG 115
Cdd:PRK00187 1 MQVPPTTELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFC-VGVIAAVGTLVAIRHGA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 116 KNLKRVGVILQRGILILLLCCFPCWAIFLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMP 195
Cdd:PRK00187 80 GDIEGATRLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 196 QVIVGIAANVVNVGMNAFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVWWKRiHIHTWG---GWTRECFQEWSSY 268
Cdd:PRK00187 160 VMVISLAGAVANLLLNYALIEGWfglpKLGLMGIGLVTALVSNGMALALALYIRRHP-AYAAYPlrkGLSRPSRAALREL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 269 TRLAIPSMFMVCIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTV 348
Cdd:PRK00187 239 WRLGLPIGGTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 349 LLCAGVCALLVGILLAALKDVVAYIFTNDKD-----IISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTI 423
Cdd:PRK00187 319 IGFGAVVMLLFAGLFWLLPEAIIGLFLDRNDpafaeIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLA 398
|
410 420
....*....|....*....|....*...
gi 85702045 424 GYYGFGFPIGVSLMFAAKLGIIGLWAGL 451
Cdd:PRK00187 399 CYWLVGAPLAWLLAFTLGWGAVGVWWGL 426
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-453 |
9.41e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 70.40 E-value: 9.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 47 LVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTGISVGTgLASACDTLMSQSFGGKNLKRVGVILQ 126
Cdd:cd13135 3 INHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGS-ISIGFTILGSQSVGAKDIKRINDYAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 127 RGIL---ILLLCCFPCWaiFLNTERLLLLLRQDPDVARLAQVYVMICIPALP-AAFLFQLQTrYLQSQGIIMPQVIVGIA 202
Cdd:cd13135 82 SSIVynsIIGVILFLLW--LFGARIIFVLFGVDGQILGYSINYVRIFSIYLLlLGILFTFSS-ILQGIGETKPIMYGGII 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 203 ANVVNVGMNAFLLYAL----DLGVVGSAWANTTSQFflSALLFLYVWWKRIHIHTWGGWTRECFQE-WSSY---TRLAIP 274
Cdd:cd13135 159 KNLLNVILDYVLIFGNfgfpRLGIIGAAIATTIANV--LNLIILVYLCRKIKKLTFKLSNTKVLKAnIRPYkftIKLGLP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 275 SMFMVcIEWWTFEIG--TFLAGLvNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQA-RCSCTTVLLC 351
Cdd:cd13135 237 LGGEE-FLWNIGNLAviRILNRI-GELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEAlRIGNICLGLG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 352 AGVCALLVGILLAaLKDVVAYIFTNDKDIISLvSQVMPIFAPFHLFDALAGT-CGGVLRGTGKQK-------IGAVLNTI 423
Cdd:cd13135 315 LLIYIAAAIVFLA-FPYKILSLFTNDPELINY-SIPYLIFIIIILFFKSINIvYGFAIRAIGDTKwmlytqiIGTIIVVS 392
|
410 420 430
....*....|....*....|....*....|
gi 85702045 424 GYYgfgfpigvSLMFAAKLGIIGLWAGLIV 453
Cdd:cd13135 393 VAL--------LLIFVFKLGLAGVYITLFI 414
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
46-468 |
3.33e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 68.72 E-value: 3.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 46 ALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVIL 125
Cdd:cd13147 10 AIIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMII-IGLGNGLGAGASSAISRRIGAKDKEGADNAA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 126 QRGILILLLCCFPCWAIFLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANV 205
Cdd:cd13147 89 VHSILLGLIISIILTIVLLPFLEPILVLMGAGEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 206 VNVGMNAFLLYALDLGVVGSAWANTTSQFFlSALLFLYvwWKRIHIHTWGGWTRECFQEWSSYT----RLAIPSMF-MVC 280
Cdd:cd13147 169 LNIILDPIFIYTLGLGIAGAAWATVISMLI-SSLVLLY--WFFVKKDTYVSLSLKNFKFDKKIVkdilKVGIPASLeQLI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 281 IEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALLVG 360
Cdd:cd13147 246 MSVLMIILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIA 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 361 ILLAALKDVVAYIFTNDKDIISLVS------QVMPIFAPFHLFDALAgtcGGVLRGTGKQKIGAVLNTIgyYGFGFPIGV 434
Cdd:cd13147 326 ILIFIFAPQIAYLFTYSEESAHLAPeivaflRIMCLFLPFVPFGMMS---SSMFQGIGKGLTSLIITIL--RELIFQVLF 400
|
410 420 430
....*....|....*....|....*....|....*....
gi 85702045 435 SLMFAA--KLGIIGLWAGLIV---CVSFQAFSYLIYILR 468
Cdd:cd13147 401 AYLFAIvlGLGLFGVWWGIVLgnaIGSIVGYLWARLYIK 439
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-474 |
2.23e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 66.10 E-value: 2.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 46 ALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVIL 125
Cdd:cd13139 15 AIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIV-YSIAIGLSMAATALVARRIGEKDPEGAGFAA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 126 QRGILILLLCCFPCWAI-FLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAAN 204
Cdd:cd13139 94 VQAILLGVALSLILSILgYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLAN 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 205 VVNVGMNAFLLYAL----DLGVVGSAWANTTSQFF--LSALLFLYVWWKRIHIHtwggwtRECFQ-EWS---SYTRLAIP 274
Cdd:cd13139 174 GLNIILDPLFIFGLgpipAMGVTGAAIATTIGRSIgvLYQLYHLFKGKGRIQIR------RRHLKlDWAiikKIIKIAVG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 275 SM--FMVCIEWWTFeigtfLAGLVnvTELGAQAVI-YELA----SVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTT 347
Cdd:cd13139 248 GIlqFLIASSSWIF-----LVRII--AEFGSTALAgYTIAiriiMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 348 VLLCAGVCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYG 427
Cdd:cd13139 321 AGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWL 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 85702045 428 FGFPIGVSLMFAAKLGIIGLWAGLIVCVSFQAFSYLIYILRTNWSRV 474
Cdd:cd13139 401 FQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKWKTV 447
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-461 |
3.37e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 65.50 E-value: 3.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 47 LVALAGPVFLAQLMIFLISIVSSIFCGHLGKVE--LDAVTLAVSVVNVTGISVGTGLASACDTLMSQSFGGKNLKRVGVI 124
Cdd:cd13146 10 LIRLALPILIGQLFQLLYNITDTIWISMIDPSDpaLVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQRAKELDQA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 125 LQRGILILLLCCFPCWAI-FLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAA 203
Cdd:cd13146 90 ADSGLALALLAATVIVVLgYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 204 NVVNVGMNAFLLYALDLGVVGSAWANTTSQfFLSALLFLYVWWKR-----IHIHTWGGwtreCFQEWSSYTRLAIPSMFM 278
Cdd:cd13146 170 TVVNIVLDPILIFVFDMGVKGAALATVLAQ-AISLLYLLYVFLIGksnvtIHIKLSNI----SSSVIVEILRVGLPQMLL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 279 VCIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALL 358
Cdd:cd13146 245 QLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 359 VGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIGVSLMF 438
Cdd:cd13146 325 LVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAY 404
|
410 420
....*....|....*....|...
gi 85702045 439 AAKLGIIGLWAGLIVCVSFQAFS 461
Cdd:cd13146 405 VFGKGITGVYFGIVSANFFTALL 427
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
41-243 |
4.17e-10 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 62.08 E-value: 4.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 41 RREAAALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKR 120
Cdd:COG0534 225 RKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQAAQPLVGQNLGAGDYDR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 121 VGVILQRGILILLLCCFPCWAIF-LNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIV 199
Cdd:COG0534 304 ARRAARLALLLALGIGLLLALLLfLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMII 383
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 85702045 200 GIAANVVNVGMNAFLLYALDLGVVGSAWANTTSQFFLSALLFLY 243
Cdd:COG0534 384 SLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-453 |
5.13e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 58.47 E-value: 5.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 46 ALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTGiSVGTGLASACDTLMSQSFGGKNLKRVGVIL 125
Cdd:cd13149 10 HLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLN-SLTIGLGIGASAVISRAIGAGDRNKAKRLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 126 QRG-ILILLLCCFPCWAIFLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAAN 204
Cdd:cd13149 89 TDSlILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLGAA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 205 VVNVGMNAFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVWWKRIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVC 280
Cdd:cd13149 169 LVNVILDPILIFGFgpipGMGIAGAAIATVISRALGLGAALYFLHYHHRLIDFSEPSLKALFRSWKDILSIGIPAALSNI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 281 IEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALLVG 360
Cdd:cd13149 249 LTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIYGAILG 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 361 ILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYygFGFPIGVSLMFAA 440
Cdd:cd13149 329 IVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRV--FLLYIPLAYVGSH 406
|
410
....*....|...
gi 85702045 441 KLGIIGLWAGLIV 453
Cdd:cd13149 407 LLGFAGVFIGALA 419
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
54-463 |
1.74e-08 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 56.50 E-value: 1.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 54 VFLAQLMIFLISIVSSIFCGH-LGKVELDAVTLAVSVVNVTGISVGTGLASAcdtlMSQSFGGKNLKRVGVILQRGILIL 132
Cdd:COG2244 11 LLLGQLLGALLGFLLLPLLARlLGPEEYGLFALALSIVALLSVLADLGLSTA----LVRFIAEYREEELRRLLSTALLLR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 133 LLCCFPCWAIFLNTERLLLLLRQDPDVARlaqvYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNA 212
Cdd:COG2244 87 LLLSLLLALLLLLLAPFIAALLGEPELAL----LLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLLLAL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 213 FLLYaLDLGVVGSAWANTTSQFFLSALLFLYVWWKRIhihtwggwtrecfqewssytrlaipsmfmvciewwtfeigtFL 292
Cdd:COG2244 163 LLAL-LGLGLWGLVLKYSLPLLLSGLLGLLLTNLDRL-----------------------------------------LL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 293 AGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALLVGILLAALKDVVAY 372
Cdd:COG2244 201 GALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLS 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 373 IFTNDKDIISlvSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIgyyGFGFPIGVSLMFAAKLGIIGLWAGLI 452
Cdd:COG2244 281 LLFGPEYAEA--APVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLI---GAVLNLVLNLLLIPRYGLVGAAIATL 355
|
410
....*....|.
gi 85702045 453 VCVSFQAFSYL 463
Cdd:COG2244 356 LSYLVLLLLLL 366
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-412 |
1.17e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 54.24 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 47 LVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVILQ 126
Cdd:cd13141 13 IISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFV-MALTQVLNVGTAALVSHAVGRKDQGEANAVFN 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 127 RGILILLLCCFPCWAI-FLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANV 205
Cdd:cd13141 92 QSLLLAAVLGLVVLVLgYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILAVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 206 VNVGMNAFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVWWK----RIHIHTWggwtRECFQEWSSYTRLAIPS-- 275
Cdd:cd13141 172 LNIILAPILITGWgtgrALGVAGAGLASSISVAIAVVLLLYYFLRLekylRLDLALW----RPDLPTWKRLLKIGLPSgg 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 276 ------MFMVCIEWWTFEIGT-----FLAG--LVNVTELGAQAVIYELASVAymvpfgfgvaasvrvGNALGAGNADQAR 342
Cdd:cd13141 248 eflltfVYMAVIYWALRPFGAaaqagFGIGsrIMQSLFLPAMAIAFAAPAIA---------------GQNFGAGNYDRVR 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 85702045 343 CSCTTVLLCagVCALLVGILLAAL--KDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTG 412
Cdd:cd13141 313 ETFRITAIL--TTALMLVLTLLCQlvPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALG 382
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
12-317 |
3.30e-07 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 52.84 E-value: 3.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 12 IQPPELVRVprGRSLRILLGLRGalsPDVRReaaaLVALAGPVFLAQLMIFLISIVSSIFCGHLGkveldavTLAVSVVN 91
Cdd:COG0728 198 IQLPALRRL--GLRLRPRFDLRD---PGVRR----VLKLMLPALLGVSVSQINLLVDTILASFLP-------EGSVSALY 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 92 --------VTGIsVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILILLLCCFPC--WAIFLNTERLLLLLRQ---DPD 158
Cdd:COG0728 262 yadrlyqlPLGL-FGVAIGTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAavGLIVLAEPIVRLLFERgafTAE 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 159 VARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNAFLLYALdlGVVGSAWANTTSqFFLSA 238
Cdd:COG0728 341 DTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPPL--GHAGLALATSLS-ALVNA 417
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 85702045 239 LLFLYVWWKRIHIHTWGGWtrecfqeWSSYTRLAIPSMFMVCIEWWTFEIGTFLAGLVNVTELGAQAVIYELASVAYMV 317
Cdd:COG0728 418 LLLLVLLRRRLGGLPLRGI-------LRTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYFA 489
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
50-451 |
8.35e-06 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 48.58 E-value: 8.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 50 LAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSvVNVTGISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGI 129
Cdd:PRK10189 34 LAVPIFIENLCVLLMGVLSTFLVSWLGKEAMAGVGLADS-FNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 130 LILLLCCFPCWAI--FLNTERLLLLLRQ-DPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVV 206
Cdd:PRK10189 113 VIMTLFAVLLAVLihFFGEQIIDLVAGDaTPEVKALALTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLLINGGMNIL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 207 NVGMNAFLLYAL----DLGVVGSAWANTTSQfFLSALLFLYVWwkrihIHTWGGWTRECFQewSSYTRLAIPSMFMV--- 279
Cdd:PRK10189 193 NIIISSILIYGLfswqGLGFVGAGLGLTISR-YIGAVAIIWVL-----MIGFNPALRISLK--SYFKPLNFAIIWEVmgi 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 280 ----CIEWWTFEIGT-----FLAGLvnVTELGAQAVI-YELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTV- 348
Cdd:PRK10189 265 gipaSIESVLFNGGKlltqmFVAGM--GTSVIAGNFIaFSIAALINLPGNALGSASTIITGTRLGKGQIAQAERQLRHVf 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 349 -LLCAGVCALlvGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYG 427
Cdd:PRK10189 343 wLSTLGLTAI--AWLSAPFAGLLASFYTQDPDVKHVVKILIWLNALFMPIWAASWVLPAGLKGARDARYAMWVSMLGMWG 420
|
410 420
....*....|....*....|....
gi 85702045 428 FGFPIGVSLMFAAKLGIIGLWAGL 451
Cdd:PRK10189 421 CRVVAGYILGIMLGFGVVGVWMGM 444
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
290-491 |
5.69e-05 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 45.78 E-value: 5.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 290 TFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALLVGILLAALKDV 369
Cdd:cd12082 19 TFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAILLGLLLAALLLFFSPL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 370 VAYIFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYY--GFGFPIGVSLMFAAKLGIIGL 447
Cdd:cd12082 99 ILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLlnILLDPLLIFGLGPPELGIAGA 178
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 85702045 448 WAGLIVCVSFQAFSYLIYILRTNWSRVAEQAQVRAGLKSTKELI 491
Cdd:cd12082 179 ALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLL 222
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
60-468 |
1.09e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 44.90 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 60 MIF--LISIVSSIFCGHLGKVELDAVTLAVSVVNVTgISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILILLLC-C 136
Cdd:cd13145 22 FFFntMFNVVDTFFAGKISTEALAALSLSFPIFFII-IAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILaI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 137 FPCWAIFLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNAFLLY 216
Cdd:cd13145 101 LLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFFLNIILDPLFIF 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 217 A----LDLGVVGSAWANTTSQFflsaLLFLYVWWK-----RIHIHTWggwtRECFQEWSSYTRLA---IPSMF-MVCIEW 283
Cdd:cd13145 181 GgggiPAMGVSGIALATIISQF----IGMFYLLYKvrksgIISGCRL----RDFIPRLDVYKEILkqgFPASLnMMTIGL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 284 WTFEIgTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARcscTTVLLCagvcaLLVGILL 363
Cdd:cd13145 253 GIFVI-TYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVR---ETYKKA-----LKYGFVI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 364 AALKDVVAY--------IFTNDKDIISLVSQVMPIFAPFHLFDALAGTCGGVLRGTgKQKIGAVLNTIGYYGFG-FPIGV 434
Cdd:cd13145 324 MVVATVFLLffaeplmsLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGL-KRPIFALWIGLYRQLVGpALVFW 402
|
410 420 430
....*....|....*....|....*....|....
gi 85702045 435 SLMFAAKLGIIGLWAGLIVCVSFQAFSYLIYILR 468
Cdd:cd13145 403 LLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTRR 436
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
22-245 |
2.75e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 43.65 E-value: 2.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 22 RGRSLRILLGLRGALSpdvRREAAALVALAGPVFLAQLMIFLISIVSS-IFCGHLGKVELDAVTLAVSVVNVTgISVGTG 100
Cdd:cd13143 206 RGKSLLKLSLLRFKLS---LKIIKEILALGFPSFLMQLSSSVVTIVLNlTLLGYGGDIGVAAFGIVTRILTFL-FLPLIG 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 101 LASACDTLMSQSFGGKNLKRVGVILQRGILILLLCCFPCWAIF-LNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFL 179
Cdd:cd13143 282 LSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLILlLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGI 361
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 85702045 180 FQLQTRYLQSQGIIMPQVIVGIAANVVnvgMNAFLLYALD--LGVVGSAWANTTSQFFLSALLFLYVW 245
Cdd:cd13143 362 NIVLSGYFQAIGKAKRAALLSLLRQGL---FLIPLLLILPrlFGLDGIWLAFPLAEILTLLLALILLK 426
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-401 |
7.97e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 42.26 E-value: 7.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 47 LVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVV----NVTGISVGTGLASAcdtlMSQSFGGKNLKRVG 122
Cdd:cd13148 14 LLRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLmltqMMSNGAMGGGVSSA----IARALGAGDRERAE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 123 VILQRGILI-LLLCCFPCWAIFLNTERLLLLLRQDPDVARLAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGI 201
Cdd:cd13148 90 ALVWHALVIaLAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVTL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 202 AANVVNVGMNAFLLYAL----DLGVVGSAWANTTSQFFLSALLFLYVWWKRIHIH---TWGGWTRECFQEWSSYTRLAIP 274
Cdd:cd13148 170 VGAVVQIPLSPGLILGWgplpRLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRlrlRALRLERRLFRDILRVGLLAAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 275 SMFMVCIewwTFEIGTFLAGLVNVTELGAqaviYELAS-VAY-MVP--FGFGVAASVRVGNALGAGNADQARCSCTTVLL 350
Cdd:cd13148 250 SPLQTNL---TVLLLTGLVGRFGTAALAG----YGIGSrLEFlLIPlvFGLGAAMTAMVGMNIGAGQIARARRIAWTGAL 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 85702045 351 CAGVCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDALA 401
Cdd:cd13148 323 MAAVLAGAIGLVLALFPELWLGLFTHDPAVLAAGASYLRIVGPFYGFFGLG 373
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
47-251 |
1.54e-03 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 41.30 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 47 LVALAGPVFLAQLMIFLISIVSSIFCGHL----GKVELDAVTL-------AVSVVNVtGISVGTGLASACDTLMSQSFGG 115
Cdd:cd13124 226 LLSYAIPITLSSLILPLLQLIDSFTVPRRlqaaGLSESEATALygiltgrAQPLVQL-PTVIATALSTSLVPAISEAYAK 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 116 KNLKRVGVILQRGILILLLCCFPC-WAIFLNTERLLLLLRQDPDVARLAQVYVMICIPAlpaaFLFQLQTRYLQSQGIIM 194
Cdd:cd13124 305 GDKKELRRRINQALRLTLLIGLPAaVGLAVLAEPINTLLFGDSEGGLILQILAPSILFL----SLQQVTAAILQGLGKVK 380
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 85702045 195 PQVIVGIAANVVNVGMNAFLLYALdlGVVGSAWANTTSqFFLSALLFLYVWWKRIHI 251
Cdd:cd13124 381 IPVINLLIGLLVKIVLNYVLIPIF--GIYGAAIATVIG-FLVAALLNLRALKKLLGF 434
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
162-446 |
1.67e-03 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 40.99 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 162 LAQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMnAFLLYALDLGVVGSAWANTTSQFFLSALLF 241
Cdd:cd13128 107 ELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLIL-ALILVLLGGGLIGFALAYLIASVLSAILLL 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 242 LYVWWKRIHIHTWggwtRECFQEWSSYTRLAIPSMFMVCIEWWTFEIGTFLAG-LVNVTELGAQAVIYELASVAYMVPFG 320
Cdd:cd13128 186 YIYRKKILLPKFF----SFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGyFLGDAAVGIYNAAYRIAELLLFIPSA 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 321 FGVAASVRVGNALgAGNADQARCSCTTVLLCAGVCALLVGILLAALKDVVAYIFTNDKdiISLVSQVMPIFAPFHLFDAL 400
Cdd:cd13128 262 ISTALFPRISELY-KNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEE--YLPAALVLQILAWGFLFIFL 338
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 85702045 401 AGTCGGVLRGTGKQKIGAVLNTIgyyGFGFPIGVSLMFAAKLGIIG 446
Cdd:cd13128 339 NGIFGSILQAIGKQKLTLKILLI---GALLNVILNLLLIPKYGIIG 381
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
270-468 |
1.89e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 41.04 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 270 RLAIPS--------MFMVciewwtfeIGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQA 341
Cdd:cd13145 13 KLAIPAsvgfffntMFNV--------VDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 342 RCSCTTVLLCAGVCALLVGILLAALKDVVAYIFTNDKDIISLVSQVM-PIFA--PFHLfdaLAGTCGGVLRGTGKQK--- 415
Cdd:cd13145 85 RRYAAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMdVIFAgsIFFL---LNFGLNGILNAQGDTKsyr 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 85702045 416 ----IGAVLNTIGYYGFGFPIGVSLmfaaKLGIIGLwAGLIVCVSFQAFSYLIYILR 468
Cdd:cd13145 162 nfliIGFFLNIILDPLFIFGGGGIP----AMGVSGI-ALATIISQFIGMFYLLYKVR 213
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
288-468 |
2.62e-03 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 40.31 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 288 IGTFLAGLVNVTELGAQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNADQARCSCTTVLLCAGVCALLVGILLAALK 367
Cdd:TIGR00797 15 VDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLALLLGLPVLLVGYFFI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 368 DVVAYIFTNDKDIISLVS---QVMPIFAPFHLFDALAGtcgGVLRGTGKQKIGAVLNTIG------------YYGFGFpi 432
Cdd:TIGR00797 95 DPLLSLMGADGEVAELAQdylRILILGIPAYLLNFVLR---GFLRGQGDTKTPMYITLIGnviniilnyiliFGKFGF-- 169
|
170 180 190
....*....|....*....|....*....|....*...
gi 85702045 433 gvslmfaakLGIIGL-WAGLIV-CVSFQAFSYLIYILR 468
Cdd:TIGR00797 170 ---------LGIVGAaLATVISyWLMFLLLLYYIKKAK 198
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
12-247 |
6.15e-03 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 39.36 E-value: 6.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 12 IQPPELVRvpRGRSLRILLGLRGalsPDVRReaaaLVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVN 91
Cdd:cd13123 191 VQLPALRR--LGFRFRPRLDFRD---PGVRR----VLKLMLPALLGVSVSQINLLVDTILASFLPEGSISALYYADRLYQ 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 92 ----VTGISVGTGLAsacdTLMSQSFGGKNLKRVGVILQRGILILLLCCFPC--WAIFLNTERLLLLLRQ---DPDVARL 162
Cdd:cd13123 262 lplgIFGVAIATALL----PRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAavGLIVLAEPIVRLLFERgafTAEDTLM 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702045 163 AQVYVMICIPALPAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNAFLLYALdlGVVGSAWANTTSQFFLSALLFL 242
Cdd:cd13123 338 TASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLIKPL--GHVGLALATSLSAWVNALLLLV 415
|
....*
gi 85702045 243 YVWWK 247
Cdd:cd13123 416 LLRRR 420
|
|
| |
