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Conserved domains on  [gi|77404281|ref|NP_001029201|]
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interleukin-17 receptor E isoform 2 [Mus musculus]

Protein Classification

IL17_R_N and SEFIR domain-containing protein( domain architecture ID 10386761)

IL17_R_N and SEFIR domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IL17_R_N super family cl20911
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
1-207 4.61e-76

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


The actual alignment was detected with superfamily member pfam15037:

Pssm-ID: 464460  Cd Length: 388  Bit Score: 242.08  E-value: 4.61e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404281     1 MCIEASYLQEDTVRRKKCPFQSWPEAYgSDFWQSIRFTDYSQHNQMVMALtlrCPLKLEASLCWRQDPLTPCETLPNATA 80
Cdd:pfam15037 200 LCIQAWPLEEDTVRTKKCPFQEDPRAH-SNLWKSARLTLLSQHSWMVDAP---CPLKAEAALCWRAPGGTLCQPLPPPLP 275
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404281    81 QES---EGWYILENVDLHPQLCFKFSFENSSHV-ECPHQSGSLPSwtvsmdtQAQQLTLHFSSRTYATFSAAWSDPGLgp 156
Cdd:pfam15037 276 RENvtvNGWYVLPLLDLHPNLCVQVSSGEKSQLqECPWADSLGPL-------QDDMLLLETSGPQHNTSSCALEHSGC-- 346
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 77404281   157 dtpmPPVYSISQTQGSvpVTLDLIIPFLRQENCILVWRSDVHFAWKhvlCP 207
Cdd:pfam15037 347 ----TPLPSVAQTRAA--RLGEQLLQDLQSGQCVQLWRDDVGFLWA---CP 388
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
247-374 1.13e-25

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


:

Pssm-ID: 254756  Cd Length: 150  Bit Score: 101.70  E-value: 1.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404281   247 RPVLLLHAADSEAQRRLVGALAELLRTALGggRDVIVDLWEGTHVARIGPLPWLWAArervAREQGTVLLLWN------C 320
Cdd:pfam08357   1 RKVFIVYSSDSALHTEVVLKFAEFLQDYCG--CEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSkgakafC 74
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77404281   321 AGPSTACSGDPQAASLRTLLCAA-------------PRPLLLAYFsRLCAKGDIPRPLRALPRYRLL 374
Cdd:pfam08357  75 DKKADKRKGGVGTESQHDLFIPAlslilrdfkqsaaLRKYLVVYF-GYADKKDVPTILRVLPKYSLM 140
 
Name Accession Description Interval E-value
IL17_R_N pfam15037
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
1-207 4.61e-76

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


Pssm-ID: 464460  Cd Length: 388  Bit Score: 242.08  E-value: 4.61e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404281     1 MCIEASYLQEDTVRRKKCPFQSWPEAYgSDFWQSIRFTDYSQHNQMVMALtlrCPLKLEASLCWRQDPLTPCETLPNATA 80
Cdd:pfam15037 200 LCIQAWPLEEDTVRTKKCPFQEDPRAH-SNLWKSARLTLLSQHSWMVDAP---CPLKAEAALCWRAPGGTLCQPLPPPLP 275
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404281    81 QES---EGWYILENVDLHPQLCFKFSFENSSHV-ECPHQSGSLPSwtvsmdtQAQQLTLHFSSRTYATFSAAWSDPGLgp 156
Cdd:pfam15037 276 RENvtvNGWYVLPLLDLHPNLCVQVSSGEKSQLqECPWADSLGPL-------QDDMLLLETSGPQHNTSSCALEHSGC-- 346
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 77404281   157 dtpmPPVYSISQTQGSvpVTLDLIIPFLRQENCILVWRSDVHFAWKhvlCP 207
Cdd:pfam15037 347 ----TPLPSVAQTRAA--RLGEQLLQDLQSGQCVQLWRDDVGFLWA---CP 388
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
247-374 1.13e-25

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


Pssm-ID: 254756  Cd Length: 150  Bit Score: 101.70  E-value: 1.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404281   247 RPVLLLHAADSEAQRRLVGALAELLRTALGggRDVIVDLWEGTHVARIGPLPWLWAArervAREQGTVLLLWN------C 320
Cdd:pfam08357   1 RKVFIVYSSDSALHTEVVLKFAEFLQDYCG--CEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSkgakafC 74
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77404281   321 AGPSTACSGDPQAASLRTLLCAA-------------PRPLLLAYFsRLCAKGDIPRPLRALPRYRLL 374
Cdd:pfam08357  75 DKKADKRKGGVGTESQHDLFIPAlslilrdfkqsaaLRKYLVVYF-GYADKKDVPTILRVLPKYSLM 140
 
Name Accession Description Interval E-value
IL17_R_N pfam15037
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
1-207 4.61e-76

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


Pssm-ID: 464460  Cd Length: 388  Bit Score: 242.08  E-value: 4.61e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404281     1 MCIEASYLQEDTVRRKKCPFQSWPEAYgSDFWQSIRFTDYSQHNQMVMALtlrCPLKLEASLCWRQDPLTPCETLPNATA 80
Cdd:pfam15037 200 LCIQAWPLEEDTVRTKKCPFQEDPRAH-SNLWKSARLTLLSQHSWMVDAP---CPLKAEAALCWRAPGGTLCQPLPPPLP 275
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404281    81 QES---EGWYILENVDLHPQLCFKFSFENSSHV-ECPHQSGSLPSwtvsmdtQAQQLTLHFSSRTYATFSAAWSDPGLgp 156
Cdd:pfam15037 276 RENvtvNGWYVLPLLDLHPNLCVQVSSGEKSQLqECPWADSLGPL-------QDDMLLLETSGPQHNTSSCALEHSGC-- 346
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 77404281   157 dtpmPPVYSISQTQGSvpVTLDLIIPFLRQENCILVWRSDVHFAWKhvlCP 207
Cdd:pfam15037 347 ----TPLPSVAQTRAA--RLGEQLLQDLQSGQCVQLWRDDVGFLWA---CP 388
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
247-374 1.13e-25

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


Pssm-ID: 254756  Cd Length: 150  Bit Score: 101.70  E-value: 1.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77404281   247 RPVLLLHAADSEAQRRLVGALAELLRTALGggRDVIVDLWEGTHVARIGPLPWLWAArervAREQGTVLLLWN------C 320
Cdd:pfam08357   1 RKVFIVYSSDSALHTEVVLKFAEFLQDYCG--CEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSkgakafC 74
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77404281   321 AGPSTACSGDPQAASLRTLLCAA-------------PRPLLLAYFsRLCAKGDIPRPLRALPRYRLL 374
Cdd:pfam08357  75 DKKADKRKGGVGTESQHDLFIPAlslilrdfkqsaaLRKYLVVYF-GYADKKDVPTILRVLPKYSLM 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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