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Conserved domains on  [gi|77917617|ref|NP_001030022|]
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reticulophagy regulator 1 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RETR1_RHD cd22560
N-terminal reticulon-homology domain of Reticulophagy regulator 1; Reticulophagy regulator 1 ...
 68-259 3.75e-137

N-terminal reticulon-homology domain of Reticulophagy regulator 1; Reticulophagy regulator 1 (RETR1 or RETREG1), also called reticulophagy receptor 1 or FAM134B (family with sequence similarity 134, member B), is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. Loss of function of FAM134B is associated with diseases and cancer, including hereditary sensory and autonomic neuropathy type IIB (HSAN IIB), colorectal adenocarcinoma, and oesophageal squamous cell carcinoma, and other progressive neuronal degenerative diseases. FAM134B is also implicated in the suppression of viral replication during Ebola, Dengue, Zika, and West Nile viral infections. RETREG1/FAM134B contains an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


:

Pssm-ID: 411699  Cd Length: 198  Bit Score: 393.74  E-value: 3.75e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617  68 VTWLLGEPVLWLGC-----RADELLSWKRPLRSLLGFVAANLLFWFLALTPWRVYHLISVMILGRVIMQIIKDMVLSRTR 142
Cdd:cd22560   2 QTWLLGEPVLWLGCgsplcRFDELLSWKRPLRSLLGFVCANLLFWFLALTPWRVYHLISLMILGLVVMQIIKDMVLSRSR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617 143 GAQLWRSLSESWEVINSKPDERPRLSHCIAESWMNFSIFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYL 222
Cdd:cd22560  82 GAQLWRSLSESWEVIDSKPDERPRLSQCIAESWMNFSAFLQEMSHFKQQNPGKFCLLVCSVCTFFTILGSYIPGVVLSYL 161

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 77917617 223 LLLCAFLCPLFKCNDIGQKIYSKIKSVLLKLDFGIGE 259
Cdd:cd22560 162 LLLCAFLCPLFKCNEFGQKVYSKVKSVLQKLDFGIGE 198
 
Name Accession Description Interval E-value
RETR1_RHD cd22560
N-terminal reticulon-homology domain of Reticulophagy regulator 1; Reticulophagy regulator 1 ...
 68-259 3.75e-137

N-terminal reticulon-homology domain of Reticulophagy regulator 1; Reticulophagy regulator 1 (RETR1 or RETREG1), also called reticulophagy receptor 1 or FAM134B (family with sequence similarity 134, member B), is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. Loss of function of FAM134B is associated with diseases and cancer, including hereditary sensory and autonomic neuropathy type IIB (HSAN IIB), colorectal adenocarcinoma, and oesophageal squamous cell carcinoma, and other progressive neuronal degenerative diseases. FAM134B is also implicated in the suppression of viral replication during Ebola, Dengue, Zika, and West Nile viral infections. RETREG1/FAM134B contains an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411699  Cd Length: 198  Bit Score: 393.74  E-value: 3.75e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617  68 VTWLLGEPVLWLGC-----RADELLSWKRPLRSLLGFVAANLLFWFLALTPWRVYHLISVMILGRVIMQIIKDMVLSRTR 142
Cdd:cd22560   2 QTWLLGEPVLWLGCgsplcRFDELLSWKRPLRSLLGFVCANLLFWFLALTPWRVYHLISLMILGLVVMQIIKDMVLSRSR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617 143 GAQLWRSLSESWEVINSKPDERPRLSHCIAESWMNFSIFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYL 222
Cdd:cd22560  82 GAQLWRSLSESWEVIDSKPDERPRLSQCIAESWMNFSAFLQEMSHFKQQNPGKFCLLVCSVCTFFTILGSYIPGVVLSYL 161

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 77917617 223 LLLCAFLCPLFKCNDIGQKIYSKIKSVLLKLDFGIGE 259
Cdd:cd22560 162 LLLCAFLCPLFKCNEFGQKVYSKVKSVLQKLDFGIGE 198
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 85-233 1.07e-04

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 42.47  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617    85 ELLSWKRPLRSLLGFVAAnLLFWFLALtpWRVYHLISVmiLGRVIMqiikdMVLSRTrgaQLWRSLSEsweVINSKPDER 164
Cdd:pfam02453   3 DLLLWRNPKKSGGVFGGA-TALWLLFE--VLGYSLLSL--VSKLLL-----LLLLVL---FLWAEYAG---KLNRPPPPI 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 77917617   165 PRLS------HCIAES---WMNFsiFLQEM-SLFKQQSPGKFCLLVCSVCtFFTILGSYIPGVILSYLLLLCAFLCPLF 233
Cdd:pfam02453  67 PELElseetvRELADSlrvLINF--ALSELrRIALGEDLKLFLKVAVVLW-ILSYVGSLFSFLTLLYIGVVLAFTVPLL 142
 
Name Accession Description Interval E-value
RETR1_RHD cd22560
N-terminal reticulon-homology domain of Reticulophagy regulator 1; Reticulophagy regulator 1 ...
 68-259 3.75e-137

N-terminal reticulon-homology domain of Reticulophagy regulator 1; Reticulophagy regulator 1 (RETR1 or RETREG1), also called reticulophagy receptor 1 or FAM134B (family with sequence similarity 134, member B), is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. Loss of function of FAM134B is associated with diseases and cancer, including hereditary sensory and autonomic neuropathy type IIB (HSAN IIB), colorectal adenocarcinoma, and oesophageal squamous cell carcinoma, and other progressive neuronal degenerative diseases. FAM134B is also implicated in the suppression of viral replication during Ebola, Dengue, Zika, and West Nile viral infections. RETREG1/FAM134B contains an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411699  Cd Length: 198  Bit Score: 393.74  E-value: 3.75e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617  68 VTWLLGEPVLWLGC-----RADELLSWKRPLRSLLGFVAANLLFWFLALTPWRVYHLISVMILGRVIMQIIKDMVLSRTR 142
Cdd:cd22560   2 QTWLLGEPVLWLGCgsplcRFDELLSWKRPLRSLLGFVCANLLFWFLALTPWRVYHLISLMILGLVVMQIIKDMVLSRSR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617 143 GAQLWRSLSESWEVINSKPDERPRLSHCIAESWMNFSIFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYL 222
Cdd:cd22560  82 GAQLWRSLSESWEVIDSKPDERPRLSQCIAESWMNFSAFLQEMSHFKQQNPGKFCLLVCSVCTFFTILGSYIPGVVLSYL 161

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 77917617 223 LLLCAFLCPLFKCNDIGQKIYSKIKSVLLKLDFGIGE 259
Cdd:cd22560 162 LLLCAFLCPLFKCNEFGQKVYSKVKSVLQKLDFGIGE 198
RETR_RHD cd22558
N-terminal reticulon-homology domain of Reticulophagy regulators and similar proteins; This ...
 68-259 7.76e-91

N-terminal reticulon-homology domain of Reticulophagy regulators and similar proteins; This subfamily includes Reticulophagy regulators 1-3. Reticulophagy regulator 1 (RETREG1/FAM134B) is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. RETREG2/FAM134A and RETREG3/FAM134C has been shown to interact with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. Members of this subfamily contain an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411697  Cd Length: 192  Bit Score: 275.34  E-value: 7.76e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617  68 VTWLLGEPVLWLGcRADELLSWKRPLRSLLGFVAANLLFWFLALTPWRVYHLISVMILGRVIMQIIKDMVLSRTRGAQLW 147
Cdd:cd22558   2 LTRLLGPYEPVIM-RAQSLLVWEKPLHSAVLLLAVNILFWLATTTSLRVFFLLAVMVMVVVCLDTWKNKIWPEIRVPPEP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617 148 RSLSESWEVINSKPDERPRLSHCIAESWMNFSIFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLCA 227
Cdd:cd22558  81 EEDPESWTPIHPRLLSVPELCRHLAESWVSFTIFLQKLWQFRKQHPGKFCLLVCSFCTCLAVIGHYVPGVLLSYIILLSL 160

                       170       180       190
                ....*....|....*....|....*....|..
gi 77917617 228 FLCPLFKCNDIGQKIYSKIKSVLLKLDFGIGE 259
Cdd:cd22558 161 LLWPLVVYHRVPQKIYTKLEPVLMQLEYSMKI 192
Arl6IP1_RETR3-like cd21102
ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and ...
 84-256 8.21e-79

ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and similar proteins; This family contains ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1) and the N-terminal reticulon-homology domain (RHD) of Reticulophagy regulators 1-3. Arl6IP1 is an endoplasmic reticulum (ER) protein that has an important role in cell conduction and material transport. Arl6IP1, a tetraspan membrane protein, is an anti-apoptotic protein specific to multicellular organisms, and is a potential player in shaping the ER tubules in mammalian cells. In Drosophila, knockdown of the Arl6IP1 gene leads to progressive motor deficit. An Arl6IP1 variant has also been associated with hereditary spastic paraplegia (HSP), motor and sensory polyneuropathy, and acromutilation. Reticulophagy regulator 1 (RETREG1/FAM134B) is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. RETREG2/FAM134A and RETREG3/FAM134C has been shown to interact with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. Arl6IP1 shows some sequence similarity to the RHD of reticulophagy regulators, which may function in inducing membrane curvature.


Pssm-ID: 411696  Cd Length: 178  Bit Score: 243.89  E-value: 8.21e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617  84 DELLSWKRPLRSLLGFVAANLLFWFLALTPWRVYHLISVMILGRVIMQIIKDMVL--SRTRGAQLWRSLSESWEVINSKP 161
Cdd:cd21102   1 QEALVWERPLRSLAIYAALNLLFWFLYYLSLRVFSLLSVFLMFICLIDYWKPIIWrgLRPRGARSNKSTSEVGFEFHPML 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617 162 DERPRLSHCIAESWMNFSIFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLCAFLCPLFKCNDIGQK 241
Cdd:cd21102  81 LSVPELCHNIAESWMSAVIFLLELLQLKEQNPGKFCLLVCVGLAVLAILGQYIPGVLLSYLILTSLLLWPLLNYHGLIDK 160

                       170
                ....*....|....*...
gi 77917617 242 IY---SKIKSVLLKLDFG 256
Cdd:cd21102 161 LYgmaKRLHPKLLKLDES 178
RETR3_RHD cd22562
N-terminal reticulon-homology domain of Reticulophagy regulator 3; Reticulophagy regulator 3 ...
 74-257 8.45e-44

N-terminal reticulon-homology domain of Reticulophagy regulator 3; Reticulophagy regulator 3 (RETR3 or RETREG3), also called FAM134C (family with sequence similarity 134, member C), mediates NRF1-enhanced neurite outgrowth. It interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. RETREG3/FAM134C contains an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an endoplasmic reticulum protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411701  Cd Length: 192  Bit Score: 152.98  E-value: 8.45e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617  74 EPVLwlgCRADELLSWKRPLRSLLGFVAANLLFWFLALTPWRVYHLISVMILGRVIMQIIKDMVLSRTRGAQLWRSLSES 153
Cdd:cd22562  10 EPLL---SYVQAVLVWERPAHSALWCLGLNAAFWFFALTSLRLVFLLAFSLMIIVCIDQWKNKIWPEIKVARPDELDNES 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617 154 WEVINSKPDERPRLSHCIAESWMNFSIFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLCAFLCPLF 233
Cdd:cd22562  87 WGFVHPRLLSVPELCHHVAEVWVSGTNFLRNLLLFKKQNPGKFCLLVCGVLTFLAVLGRYIPGLLLSYLLLLFVLLWPLA 166

                       170       180
                ....*....|....*....|....
gi 77917617 234 KCNDIGQKIYSKIKSVLLKLDFGI 257
Cdd:cd22562 167 VYHRLGQRIYVKLEPALQRLDFSV 190
RETR2_RHD cd22561
N-terminal reticulon-homology domain of Reticulophagy regulator 2; Reticulophagy regulator 2 ...
 74-255 8.47e-39

N-terminal reticulon-homology domain of Reticulophagy regulator 2; Reticulophagy regulator 2 (RETR2 or RETREG2), also called FAM134A (family with sequence similarity 134, member A), C2orf17, or MAG2, interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. RETREG2/FAM134A contains an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an endoplasmic reticulum protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411700  Cd Length: 199  Bit Score: 139.92  E-value: 8.47e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617  74 EPVLWLgcrADELLSWKRPLRSLLGFVAANLLFWFLALTPWRVYHLISVMILGRVIMQIIKDMVLSRTRgAQLWRSLSES 153
Cdd:cd22561  14 EPVLAA---AQRLLVWERPLHSLVTAAALNGLFWLLSSTSLRPFFLLSVSLLGYFLLERWKPRLLPDVS-APSPEEPHSD 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617 154 WEVINSKPDER----PRLSHCIAESWMNFSIFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLCAFL 229
Cdd:cd22561  90 SEGAGSGAQPHllsvPELCHYLAESWLTFQLYLQELLQYKRQNPGQFCARVCSGCAVLAVLGHYVPGIMISYIVLLSVLL 169

                       170       180
                ....*....|....*....|....*.
gi 77917617 230 CPLFKCNDIGQKIYSKIKSVLLKLDF 255
Cdd:cd22561 170 WPLVVYHELIQRMYTRLEPVLMKLDY 195
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 85-233 1.07e-04

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 42.47  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77917617    85 ELLSWKRPLRSLLGFVAAnLLFWFLALtpWRVYHLISVmiLGRVIMqiikdMVLSRTrgaQLWRSLSEsweVINSKPDER 164
Cdd:pfam02453   3 DLLLWRNPKKSGGVFGGA-TALWLLFE--VLGYSLLSL--VSKLLL-----LLLLVL---FLWAEYAG---KLNRPPPPI 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 77917617   165 PRLS------HCIAES---WMNFsiFLQEM-SLFKQQSPGKFCLLVCSVCtFFTILGSYIPGVILSYLLLLCAFLCPLF 233
Cdd:pfam02453  67 PELElseetvRELADSlrvLINF--ALSELrRIALGEDLKLFLKVAVVLW-ILSYVGSLFSFLTLLYIGVVLAFTVPLL 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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