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Conserved domains on  [gi|78190492|ref|NP_001030025|]
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X-linked retinitis pigmentosa GTPase regulator isoform C [Homo sapiens]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-360 3.67e-65

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 224.47  E-value: 3.67e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492   38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALkpEKVKLAACGRNHTLVSTEGGNVYATGGNNEG 117
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492  118 QLGLGDTEERNTFHVISFFTSehkIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIG-KPVSWIS 196
Cdd:COG5184   79 QLGDGTTTDRTTPVKVPGLTG---VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492  197 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEIPEkVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLG 275
Cdd:COG5184  156 AGGYHTCALKSDGTVWCWGANSYGQLGDGTT--TDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDgTVWCWGSNSSGQLG 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492  276 LGTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPTLCSNFLRfiVKLV 354
Cdd:COG5184  233 DGTTTDRAT-PVQVAGLTG--VVAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLSG--VVAV 304


                 ....*.
gi 78190492  355 ACGGCH 360
Cdd:COG5184  305 AAGSSH 310
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-360 3.67e-65

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 224.47  E-value: 3.67e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492   38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALkpEKVKLAACGRNHTLVSTEGGNVYATGGNNEG 117
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492  118 QLGLGDTEERNTFHVISFFTSehkIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIG-KPVSWIS 196
Cdd:COG5184   79 QLGDGTTTDRTTPVKVPGLTG---VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492  197 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEIPEkVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLG 275
Cdd:COG5184  156 AGGYHTCALKSDGTVWCWGANSYGQLGDGTT--TDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDgTVWCWGSNSSGQLG 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492  276 LGTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPTLCSNFLRfiVKLV 354
Cdd:COG5184  233 DGTTTDRAT-PVQVAGLTG--VVAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLSG--VVAV 304


                 ....*.
gi 78190492  355 ACGGCH 360
Cdd:COG5184  305 AAGSSH 310
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
158-205 3.67e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 64.85  E-value: 3.67e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 78190492    158 DGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFV 205
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGlsGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-360 3.67e-65

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 224.47  E-value: 3.67e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492   38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALkpEKVKLAACGRNHTLVSTEGGNVYATGGNNEG 117
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492  118 QLGLGDTEERNTFHVISFFTSehkIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIG-KPVSWIS 196
Cdd:COG5184   79 QLGDGTTTDRTTPVKVPGLTG---VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492  197 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEIPEkVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLG 275
Cdd:COG5184  156 AGGYHTCALKSDGTVWCWGANSYGQLGDGTT--TDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDgTVWCWGSNSSGQLG 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492  276 LGTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPTLCSNFLRfiVKLV 354
Cdd:COG5184  233 DGTTTDRAT-PVQVAGLTG--VVAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLSG--VVAV 304


                 ....*.
gi 78190492  355 ACGGCH 360
Cdd:COG5184  305 AAGSSH 310
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-341 1.08e-63

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 220.23  E-value: 1.08e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492   38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPekVKLAACGRNHTLVSTEGGNVYATGGNNEG 117
Cdd:COG5184   51 VAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSG 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492  118 QLGLGDTEERNTFHVISffTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISC 197
Cdd:COG5184  129 QLGDGTTTNRLTPVQVD--AGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSGVVAVAA 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492  198 GYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEiPEKVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLGL 276
Cdd:COG5184  207 GGDHSCALKSDGTVWCWGSNSSGQLGDGTT--TDRATPVQVAG-LTGVVAIAAGGSHTCALKSDgTVWCWGDNSYGQLGD 283

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 78190492  277 GTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPT 341
Cdd:COG5184  284 GTTTDRST-PVKVPGLSG--VVAVAAGSSHTcALLTD-GTVWCWGDNAYGQLGDG--TTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 37-129 6.96e-19

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 89.65  E-value: 6.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492   37 PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPekVKLAACGRNHTLVSTEGGNVYATGGNNE 116
Cdd:COG5184  251 VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCALLTDGTVWCWGDNAY 328

                         90
                 ....*....|...
gi 78190492  117 GQLGLGDTEERNT 129
Cdd:COG5184  329 GQLGDGTTTDRST 341
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
158-205 3.67e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 64.85  E-value: 3.67e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 78190492    158 DGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFV 205
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGlsGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
55-101 1.02e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.61  E-value: 1.02e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 78190492     55 KLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLV 101
Cdd:pfam00415    3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
263-310 1.16e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 57.53  E-value: 1.16e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 78190492    263 VYTFGLGQFGQLGLGTFlFETSEPKVIENIRDQTISYISCGENHTALI 310
Cdd:pfam00415    4 VYTWGRNDYGQLGLGTT-ENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
208-258 2.37e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 56.76  E-value: 2.37e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 78190492    208 DGELYVFGEPENGKLGLPNQLlgNHRTPQLVSEIPE-KVIQVACGGEHTVVL 258
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTE--NVLVPQKVEGLSGnKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
142-171 2.72e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 53.20  E-value: 2.72e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 78190492    142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQ 171
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
106-155 8.77e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 46.74  E-value: 8.77e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 78190492    106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFtSEHKIKQLSAGSNTSAAL 155
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGL-SGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
89-118 1.39e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 45.49  E-value: 1.39e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 78190492     89 VKLAACGRNHTLVSTEGGNVYATGGNNEGQ 118
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
245-273 8.49e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.57  E-value: 8.49e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 78190492    245 VIQVACGGEHTVVLTEN-AVYTFGLGQFGQ 273
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDgRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
314-360 9.42e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 43.66  E-value: 9.42e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 78190492    314 GLMYTFGDGRHGKLGLGleNFTNHFIPTLCSNFLRFIVKLVACGGCH 360
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLG--TTENVLVPQKVEGLSGNKVVQVACGGDH 46
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
38-66 1.93e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.41  E-value: 1.93e-05
                           10        20
                   ....*....|....*....|....*....
gi 78190492     38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQ 66
Cdd:pfam13540    2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
195-220 3.10e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 41.64  E-value: 3.10e-05
                           10        20
                   ....*....|....*....|....*.
gi 78190492    195 ISCGYYHSAFVTTDGELYVFGEPENG 220
Cdd:pfam13540    4 VAAGDNHTLALTSDGRVYCWGDNSYG 29
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
297-325 9.16e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 37.79  E-value: 9.16e-04
                           10        20
                   ....*....|....*....|....*....
gi 78190492    297 ISYISCGENHTALITDIGLMYTFGDGRHG 325
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYG 29
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
46-215 2.66e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 41.29  E-value: 2.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492   46 HSAVVTGNNKLYMFGSNNWGQlglGSKSAIskptcvkALKPEK---VKLAAC---GRNHTLVSTEGGNVYATGGNNEGQl 119
Cdd:COG3055   15 EAAAALLDGKVYVAGGLSGGS---ASNSFE-------VYDPATntwSELAPLpgpPRHHAAAVAQDGKLYVFGGFTGAN- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78190492  120 glGDTEERNTFHVISFFTSE-HKIKQLSAGSNTSAALTEDGRLFMWGdnseGQIGLKNVSNVCVPQQVTigkpVSWISCG 198
Cdd:COG3055   84 --PSSTPLNDVYVYDPATNTwTKLAPMPTPRGGATALLLDGKIYVVG----GWDDGGNVAWVEVYDPAT----GTWTQLA 153

                        170       180
                 ....*....|....*....|...
gi 78190492  199 ------YYHSAFVTTDGELYVFG 215
Cdd:COG3055  154 plptprDHLAAAVLPDGKILVIG 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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