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Conserved domains on  [gi|89903023|ref|NP_001034935|]
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izumo sperm-egg fusion protein 4 isoform 3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IZUMO super family cl20883
Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of ...
 18-157 1.96e-34

Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of the immunoglobulin domain on Izumo proteins in higher eukaryotes. The actual function of this region of the Izumo proteins is not known. The full-length protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific.


The actual alignment was detected with superfamily member pfam15005:

Pssm-ID: 464437  Cd Length: 142  Bit Score: 120.06  E-value: 1.96e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89903023    18 CLHCHSNFSKKFSFYRHHVNFKSW--WVGDIPVSGALLTDWSDdtmKELHL-AIPAKITREKLDQVATAVYQMMDQLYQG 94
Cdd:pfam15005   1 CLQCDPSVVEALKSLRGDLVPSHLphRKQLMERQQALLLDFSF---KDYALnAFLGVVDEDTLDKVAWSLKNDLKRLTDS 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 89903023    95 KMYFPGYFpNELRNIFREQVHLIQNAIIESRID--CQHRCGIFQYETISCNNCTDSHVACF-GYNC 157
Cdd:pfam15005  78 DLKGEPLL-KELLWMRQNQKKKLKKALKEFQKEacCPNKCGVMLQPVLDCWTCQKITHKCFkGKYC 142
 
Name Accession Description Interval E-value
IZUMO pfam15005
Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of ...
 18-157 1.96e-34

Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of the immunoglobulin domain on Izumo proteins in higher eukaryotes. The actual function of this region of the Izumo proteins is not known. The full-length protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific.


Pssm-ID: 464437  Cd Length: 142  Bit Score: 120.06  E-value: 1.96e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89903023    18 CLHCHSNFSKKFSFYRHHVNFKSW--WVGDIPVSGALLTDWSDdtmKELHL-AIPAKITREKLDQVATAVYQMMDQLYQG 94
Cdd:pfam15005   1 CLQCDPSVVEALKSLRGDLVPSHLphRKQLMERQQALLLDFSF---KDYALnAFLGVVDEDTLDKVAWSLKNDLKRLTDS 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 89903023    95 KMYFPGYFpNELRNIFREQVHLIQNAIIESRID--CQHRCGIFQYETISCNNCTDSHVACF-GYNC 157
Cdd:pfam15005  78 DLKGEPLL-KELLWMRQNQKKKLKKALKEFQKEacCPNKCGVMLQPVLDCWTCQKITHKCFkGKYC 142
 
Name Accession Description Interval E-value
IZUMO pfam15005
Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of ...
 18-157 1.96e-34

Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of the immunoglobulin domain on Izumo proteins in higher eukaryotes. The actual function of this region of the Izumo proteins is not known. The full-length protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific.


Pssm-ID: 464437  Cd Length: 142  Bit Score: 120.06  E-value: 1.96e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89903023    18 CLHCHSNFSKKFSFYRHHVNFKSW--WVGDIPVSGALLTDWSDdtmKELHL-AIPAKITREKLDQVATAVYQMMDQLYQG 94
Cdd:pfam15005   1 CLQCDPSVVEALKSLRGDLVPSHLphRKQLMERQQALLLDFSF---KDYALnAFLGVVDEDTLDKVAWSLKNDLKRLTDS 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 89903023    95 KMYFPGYFpNELRNIFREQVHLIQNAIIESRID--CQHRCGIFQYETISCNNCTDSHVACF-GYNC 157
Cdd:pfam15005  78 DLKGEPLL-KELLWMRQNQKKKLKKALKEFQKEacCPNKCGVMLQPVLDCWTCQKITHKCFkGKYC 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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