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Conserved domains on  [gi|89886480|ref|NP_001034966|]
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striatin-4 isoform 2 [Homo sapiens]

Protein Classification

striatin( domain architecture ID 10548818)

striatin, a WD40 repeat protein which may function as scaffolding or signaling protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 437-759 2.22e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.17  E-value: 2.22e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 437 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVAMGSNSEYCYSG 516
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 517 GADACIHSWKIPDlsmdpydgydpSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSpaCLCTFPTAsE 596
Cdd:cd00200  70 SSDKTIRLWDLET-----------GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGH-T 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 597 HGVpTSVAFTSTEpaHIVASFRSGDTV-LYDMEVGSALLTLEsrGSSGPtqINQVVSHPNQPLTITAHDDRGIRFLDNRT 675
Cdd:cd00200 136 DWV-NSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 676 GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 755
Cdd:cd00200 209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                ....
gi 89886480 756 AKVF 759
Cdd:cd00200 285 IRIW 288
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-189 4.37e-41

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


:

Pssm-ID: 462401  Cd Length: 85  Bit Score: 144.95  E-value: 4.37e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480    65 LPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERakyhklkfgtdlnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 89886480   145 ekkadvseqvsngpvesvtlensplVWKEGRQLLRQYLEEVGYTD 189
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 437-759 2.22e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.17  E-value: 2.22e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 437 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVAMGSNSEYCYSG 516
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 517 GADACIHSWKIPDlsmdpydgydpSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSpaCLCTFPTAsE 596
Cdd:cd00200  70 SSDKTIRLWDLET-----------GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGH-T 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 597 HGVpTSVAFTSTEpaHIVASFRSGDTV-LYDMEVGSALLTLEsrGSSGPtqINQVVSHPNQPLTITAHDDRGIRFLDNRT 675
Cdd:cd00200 136 DWV-NSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 676 GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 755
Cdd:cd00200 209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                ....
gi 89886480 756 AKVF 759
Cdd:cd00200 285 IRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
433-758 2.73e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.13  E-value: 2.73e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 433 KTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHRGPVLAVAMGSNSEY 512
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKL 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 513 CYSGGADACIHSWKIPDLSmdpydgydpsvLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSssPACLCTFP 592
Cdd:COG2319 177 LASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT--GKLLRTLT 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 593 TASehGVPTSVAFtSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSgptqINQVVSHPNQPLTITAHDDRGIRFLD 672
Cdd:COG2319 244 GHS--GSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG----VNSVAFSPDGKLLASGSDDGTVRLWD 316

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 673 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGA 752
Cdd:COG2319 317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG----HTGAVTSVAFSPDGRTLASGSA 392


                ....*.
gi 89886480 753 DALAKV 758
Cdd:COG2319 393 DGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-189 4.37e-41

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 144.95  E-value: 4.37e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480    65 LPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERakyhklkfgtdlnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 89886480   145 ekkadvseqvsngpvesvtlensplVWKEGRQLLRQYLEEVGYTD 189
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 540-579 1.34e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 59.63  E-value: 1.34e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 89886480    540 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 579
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
545-579 1.46e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 56.58  E-value: 1.46e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 89886480   545 HVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 579
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 501-727 2.68e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480  501 VLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGlafSPTSQRLASCSADGTVRIWDP 580
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELASRSKLSGICWN---SYIKSQVASSNFEGVVQVWDV 562

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480  581 SSSSpacLCTFPTASEHGVpTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINqvvSHPNQPLTI 660
Cdd:PLN00181 563 ARSQ---LVTEMKEHEKRV-WSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFP---SESGRSLAF 635

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 89886480  661 TAHDDRgIRFLDNRTGK-PVHSMVAHLDAVTCLA-VDpnGAFLMSGSHDCSLRLWSLD------NKTCVQEITAH 727
Cdd:PLN00181 636 GSADHK-VYYYDLRNPKlPLCTMIGHSKTVSYVRfVD--SSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGH 707
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 437-759 2.22e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.17  E-value: 2.22e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 437 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVAMGSNSEYCYSG 516
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 517 GADACIHSWKIPDlsmdpydgydpSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSpaCLCTFPTAsE 596
Cdd:cd00200  70 SSDKTIRLWDLET-----------GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGH-T 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 597 HGVpTSVAFTSTEpaHIVASFRSGDTV-LYDMEVGSALLTLEsrGSSGPtqINQVVSHPNQPLTITAHDDRGIRFLDNRT 675
Cdd:cd00200 136 DWV-NSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 676 GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 755
Cdd:cd00200 209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                ....
gi 89886480 756 AKVF 759
Cdd:cd00200 285 IRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
433-758 2.73e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.13  E-value: 2.73e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 433 KTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHRGPVLAVAMGSNSEY 512
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKL 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 513 CYSGGADACIHSWKIPDLSmdpydgydpsvLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSssPACLCTFP 592
Cdd:COG2319 177 LASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT--GKLLRTLT 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 593 TASehGVPTSVAFtSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSgptqINQVVSHPNQPLTITAHDDRGIRFLD 672
Cdd:COG2319 244 GHS--GSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG----VNSVAFSPDGKLLASGSDDGTVRLWD 316

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 673 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGA 752
Cdd:COG2319 317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG----HTGAVTSVAFSPDGRTLASGSA 392


                ....*.
gi 89886480 753 DALAKV 758
Cdd:COG2319 393 DGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 424-714 7.26e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 174.06  E-value: 7.26e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 424 LSDSKDAFKKTWN-----PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKavtakknaaldVEPIHAFRAHR 498
Cdd:cd00200  25 ATGSGDGTIKVWDletgeLLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET-----------GECVRTLTGHT 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 499 GPVLAVAMGSNSEYCYSGGADACIHSWKIPDlsmdpydgydpSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 578
Cdd:cd00200  94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVET-----------GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 579 DPSSSSpaCLCTFpTASEHGVpTSVAFTSTEPAHIVASfrSGDTV-LYDMEVGSALLTLESRGSSgptqINQVVSHPNQP 657
Cdd:cd00200 163 DLRTGK--CVATL-TGHTGEV-NSVAFSPDGEKLLSSS--SDGTIkLWDLSTGKCLGTLRGHENG----VNSVAFSPDGY 232

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 89886480 658 LTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 714
Cdd:cd00200 233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
424-717 8.10e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.16  E-value: 8.10e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 424 LSDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHR 498
Cdd:COG2319 136 ASGSADGTVRLWDLAtgkllRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-----------KLLRTLTGHT 204

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 499 GPVLAVAMGSNSEYCYSGGADACIHSWkipdlsmDPYDGydpsVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 578
Cdd:COG2319 205 GAVRSVAFSPDGKLLASGSADGTVRLW-------DLATG----KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 579 DPSSssPACLCTFPTASehGVPTSVAFTSTepAHIVASFRSGDTV-LYDMEVGSALLTLESRGSSgptqINQVVSHPNQP 657
Cdd:COG2319 274 DLAT--GELLRTLTGHS--GGVNSVAFSPD--GKLLASGSDDGTVrLWDLATGKLLRTLTGHTGA----VRSVAFSPDGK 343

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 658 LTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDN 717
Cdd:COG2319 344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-189 4.37e-41

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 144.95  E-value: 4.37e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480    65 LPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERakyhklkfgtdlnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 89886480   145 ekkadvseqvsngpvesvtlensplVWKEGRQLLRQYLEEVGYTD 189
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 COG2319
WD40 repeat [General function prediction only];
439-759 6.69e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.07  E-value: 6.69e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 439 FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWnlqkavtakknAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGA 518
Cdd:COG2319  30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLL-----------DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 519 DACIHSWKIpdlsmdpydgyDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSssPACLCTFPTASehG 598
Cdd:COG2319  99 DGTVRLWDL-----------ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTGHS--G 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 599 VPTSVAFTSTEpaHIVASFRSGDTV-LYDMEVGSALLTLesRGSSGPtqINQVVSHPNQPLTITAHDDRGIRFLDNRTGK 677
Cdd:COG2319 164 AVTSVAFSPDG--KLLASGSDDGTVrLWDLATGKLLRTL--TGHTGA--VRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 678 PVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHrkkhEEAIHAVACHPSKALIASAGADALAK 757
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----SGGVNSVAFSPDGKLLASGSDDGTVR 313


                ..
gi 89886480 758 VF 759
Cdd:COG2319 314 LW 315
WD40 COG2319
WD40 repeat [General function prediction only];
558-759 1.39e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 1.39e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 558 AFSPTSQRLASCSADGTVRIWDPSSSSPAclctfPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLE 637
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALL-----LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480 638 SRGSSgptqINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDN 717
Cdd:COG2319  76 GHTAA----VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 89886480 718 KTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADALAKVF 759
Cdd:COG2319 152 GKLLRTLTG----HSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 540-579 1.34e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 59.63  E-value: 1.34e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 89886480    540 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 579
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
545-579 1.46e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 56.58  E-value: 1.46e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 89886480   545 HVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 579
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 675-714 3.42e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 3.42e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 89886480    675 TGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 714
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
676-714 5.56e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 5.56e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 89886480   676 GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 714
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 434-473 2.16e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 2.16e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 89886480    434 TWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWN 473
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
435-473 4.01e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 4.01e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 89886480   435 WNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWN 473
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 501-727 2.68e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480  501 VLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGlafSPTSQRLASCSADGTVRIWDP 580
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELASRSKLSGICWN---SYIKSQVASSNFEGVVQVWDV 562

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886480  581 SSSSpacLCTFPTASEHGVpTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINqvvSHPNQPLTI 660
Cdd:PLN00181 563 ARSQ---LVTEMKEHEKRV-WSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFP---SESGRSLAF 635

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 89886480  661 TAHDDRgIRFLDNRTGK-PVHSMVAHLDAVTCLA-VDpnGAFLMSGSHDCSLRLWSLD------NKTCVQEITAH 727
Cdd:PLN00181 636 GSADHK-VYYYDLRNPKlPLCTMIGHSKTVSYVRfVD--SSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGH 707
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 489-526 5.56e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 5.56e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 89886480    489 EPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 526
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 676-713 1.12e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.98  E-value: 1.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 89886480   676 GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 713
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVW 151
WD40 pfam00400
WD domain, G-beta repeat;
489-525 1.87e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.87e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 89886480   489 EPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSW 525
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 77-130 7.71e-03

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 39.33  E-value: 7.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 89886480    77 ARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERA 130
Cdd:pfam00529  54 TDYQAALDSAEAQLAKAQAQVARLQAELDRLQALESELAISRQDYDGATAQLRA 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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