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Conserved domains on  [gi|98985801|ref|NP_001035741|]
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T-cell surface glycoprotein CD3 delta chain isoform B precursor [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein; fibroblast growth factor receptor 1( domain architecture ID 10309747)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and pattern recognition; similar to Drosophila melanogaster DIP/Dpr cell recognition proteins, which are members of the Wirin family of IgSF proteins with neuronal wiring functions, and human IgLON proteins, a family of cell adhesion molecules| fibroblast growth factor receptor 1 (FGFR1) is a receptor tyrosine-protein kinase contains an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain that catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates; it binds the ligands, FGF1 and FGF2, with high affinity and has also been reported to bind FGF4, FGF6, and FGF9

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 25-91 1.67e-28

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd07691:

Pssm-ID: 472250  Cd Length: 69  Bit Score: 98.77  E-value: 1.67e-28
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 98985801  25 PIEELEDRVFVNCN--TSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDiykDKESTVQVHYR 91
Cdd:cd07691   1 SVKENEDKVFLKCNsaSSITWKKGTEGIEASDKTDLDLGSRINDPRGTYQCKGSE---NKEKTLQVHYR 66
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 102-121 1.32e-06

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


:

Pssm-ID: 426646  Cd Length: 20  Bit Score: 41.98  E-value: 1.32e-06
                          10        20
                  ....*....|....*....|
gi 98985801   102 DQVYQPLRDRDDAQYSHLGG 121
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
 
Name Accession Description Interval E-value
IgC1_CD3_gamma_delta cd07691
Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; ...
 25-91 1.67e-28

Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; member of the C1-set of IgSF domains; The members here are composed of immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signaling once the TCR has bound an MHC/antigen complex.


Pssm-ID: 409488  Cd Length: 69  Bit Score: 98.77  E-value: 1.67e-28
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 98985801  25 PIEELEDRVFVNCN--TSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDiykDKESTVQVHYR 91
Cdd:cd07691   1 SVKENEDKVFLKCNsaSSITWKKGTEGIEASDKTDLDLGSRINDPRGTYQCKGSE---NKEKTLQVHYR 66
Ig_4 pfam16680
T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is ...
 30-91 3.99e-23

T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is found on the T-cell surface glycoprotein CD3 delta chain. CD3delta and CD3epsilon complex together as part of the T-cell receptor complex.


Pssm-ID: 465231  Cd Length: 63  Bit Score: 84.99  E-value: 3.99e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 98985801    30 EDRVFVNCNT---SITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGtdiYKDKESTVQVHYR 91
Cdd:pfam16680   1 DGKVLLTCNSsskSITWLKDGKGIKSTNTKTLDLGKFSEDPRGLYQCQG---EKKKSSTLQVYYR 62
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 102-121 1.32e-06

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


Pssm-ID: 426646  Cd Length: 20  Bit Score: 41.98  E-value: 1.32e-06
                          10        20
                  ....*....|....*....|
gi 98985801   102 DQVYQPLRDRDDAQYSHLGG 121
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 102-122 7.53e-05

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 37.36  E-value: 7.53e-05
                           10        20
                   ....*....|....*....|.
gi 98985801    102 DQVYQPLRDRDDAQYSHLGGN 122
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
 
Name Accession Description Interval E-value
IgC1_CD3_gamma_delta cd07691
Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; ...
 25-91 1.67e-28

Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; member of the C1-set of IgSF domains; The members here are composed of immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signaling once the TCR has bound an MHC/antigen complex.


Pssm-ID: 409488  Cd Length: 69  Bit Score: 98.77  E-value: 1.67e-28
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 98985801  25 PIEELEDRVFVNCN--TSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDiykDKESTVQVHYR 91
Cdd:cd07691   1 SVKENEDKVFLKCNsaSSITWKKGTEGIEASDKTDLDLGSRINDPRGTYQCKGSE---NKEKTLQVHYR 66
Ig_4 pfam16680
T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is ...
 30-91 3.99e-23

T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is found on the T-cell surface glycoprotein CD3 delta chain. CD3delta and CD3epsilon complex together as part of the T-cell receptor complex.


Pssm-ID: 465231  Cd Length: 63  Bit Score: 84.99  E-value: 3.99e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 98985801    30 EDRVFVNCNT---SITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGtdiYKDKESTVQVHYR 91
Cdd:pfam16680   1 DGKVLLTCNSsskSITWLKDGKGIKSTNTKTLDLGKFSEDPRGLYQCQG---EKKKSSTLQVYYR 62
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 102-121 1.32e-06

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


Pssm-ID: 426646  Cd Length: 20  Bit Score: 41.98  E-value: 1.32e-06
                          10        20
                  ....*....|....*....|
gi 98985801   102 DQVYQPLRDRDDAQYSHLGG 121
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 102-122 7.53e-05

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 37.36  E-value: 7.53e-05
                           10        20
                   ....*....|....*....|.
gi 98985801    102 DQVYQPLRDRDDAQYSHLGGN 122
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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