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Conserved domains on  [gi|113195628|ref|NP_001037817|]
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dynein assembly factor with WD repeat domains 1 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
86-405 3.14e-109

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 327.25  E-value: 3.14e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  86 RALQAHILPLTNVAFNKSGSCFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFNnPYGDKVATGSFDKTCKLWSAE 165
Cdd:COG2319   72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLA 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 166 TGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAIL 245
Cdd:COG2319  151 TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 246 WDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASADG 325
Cdd:COG2319  231 WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 326 TSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVWCVKTGACLQVLEGHSDEIFSCAFNYEGDTIITG 405
Cdd:COG2319  311 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
CEP19 super family cl20818
CEP19-like protein; This family includes the centrosomal protein of 19 kDa found in eukaryotes. ...
 4-81 4.62e-04

CEP19-like protein; This family includes the centrosomal protein of 19 kDa found in eukaryotes. In humans, it is encoded for by the gene CEP19 which is also known as C3orf34. These proteins localize in the centrosomes. Centrosomes are dynamic organelles that assemble around the centrioles. They organize the microtubule cytoskeleton and mitotic spindle apparatus and are required for cell division and cell migration. C3orf34 localizes near the centrosome in early interphase, to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase.


The actual alignment was detected with superfamily member pfam14933:

Pssm-ID: 373400  Cd Length: 150  Bit Score: 40.38  E-value: 4.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628    4 KRMHIRYYPPGIFLDYEKG--GQLRTKCIDLLNLTPETDVEelvleiRAAEPLITSScveQVKLLICKLQEKVSQKDERK 81
Cdd:pfam14933   1 KKCGIRFQPPALIIFYEDKeaGKLRRRTIPLRNFSKNSDVA------RLAERLKKNP---RHKSYLERVSLLQLEKLIGL 71
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
86-405 3.14e-109

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 327.25  E-value: 3.14e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  86 RALQAHILPLTNVAFNKSGSCFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFNnPYGDKVATGSFDKTCKLWSAE 165
Cdd:COG2319   72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLA 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 166 TGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAIL 245
Cdd:COG2319  151 TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 246 WDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASADG 325
Cdd:COG2319  231 WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 326 TSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVWCVKTGACLQVLEGHSDEIFSCAFNYEGDTIITG 405
Cdd:COG2319  311 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-372 2.53e-93

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 282.30  E-value: 2.53e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  84 LFRALQAHILPLTNVAFNKSGSCFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFNnPYGDKVATGSFDKTCKLWS 163
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 164 AETGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTA 243
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 244 ILWDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASA 323
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 113195628 324 DGTSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVW 372
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 98-364 4.98e-15

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 77.05  E-value: 4.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  98 VAFNKSGSCFITGSYDRTCKIWDTAS----GEELH----TLEGhRNVVYAIAFNNPYGDKVATGSFDKTCKLWSAETGKC 169
Cdd:PLN00181 489 IGFDRDGEFFATAGVNKKIKIFECESiikdGRDIHypvvELAS-RSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQL 567

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 170 FYTFRGHTAEIVCLAFNPQS-TLVATGSMDTTAKLWDVESGEEVSTLAGHfAEIISLCF-NTTGDRLVTGSFDHTAILWD 247
Cdd:PLN00181 568 VTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQFpSESGRSLAFGSADHKVYYYD 646

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 248 VPSGR-KVHVLSGHRGEISCVQFnWDCSLIATASLDKSCKVWD----AEG--GQCLATLLGHNDEVLDVCFNYTGQLIAT 320
Cdd:PLN00181 647 LRNPKlPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDlsmsISGinETPLHSFMGHTNVKNFVGLSVSDGYIAT 725

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 321 ASAdgTSRVF----------------STDTFQCLcQLEGHKGEISKVCFNAQGSRVLTAS 364
Cdd:PLN00181 726 GSE--TNEVFvyhkafpmpvlsykfkTIDPVSGL-EVDDASQFISSVCWRGQSSTLVAAN 782
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 166-205 9.81e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 9.81e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 113195628   166 TGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWD 205
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
167-205 2.95e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 2.95e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 113195628  167 GKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWD 205
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
CEP19 pfam14933
CEP19-like protein; This family includes the centrosomal protein of 19 kDa found in eukaryotes. ...
 4-81 4.62e-04

CEP19-like protein; This family includes the centrosomal protein of 19 kDa found in eukaryotes. In humans, it is encoded for by the gene CEP19 which is also known as C3orf34. These proteins localize in the centrosomes. Centrosomes are dynamic organelles that assemble around the centrioles. They organize the microtubule cytoskeleton and mitotic spindle apparatus and are required for cell division and cell migration. C3orf34 localizes near the centrosome in early interphase, to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase.


Pssm-ID: 373400  Cd Length: 150  Bit Score: 40.38  E-value: 4.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628    4 KRMHIRYYPPGIFLDYEKG--GQLRTKCIDLLNLTPETDVEelvleiRAAEPLITSScveQVKLLICKLQEKVSQKDERK 81
Cdd:pfam14933   1 KKCGIRFQPPALIIFYEDKeaGKLRRRTIPLRNFSKNSDVA------RLAERLKKNP---RHKSYLERVSLLQLEKLIGL 71
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
86-405 3.14e-109

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 327.25  E-value: 3.14e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  86 RALQAHILPLTNVAFNKSGSCFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFNnPYGDKVATGSFDKTCKLWSAE 165
Cdd:COG2319   72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLA 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 166 TGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAIL 245
Cdd:COG2319  151 TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 246 WDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASADG 325
Cdd:COG2319  231 WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 326 TSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVWCVKTGACLQVLEGHSDEIFSCAFNYEGDTIITG 405
Cdd:COG2319  311 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
84-372 2.51e-102

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 309.53  E-value: 2.51e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  84 LFRALQAHILPLTNVAFNKSGSCFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFNnPYGDKVATGSFDKTCKLWS 163
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 164 AETGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTA 243
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 244 ILWDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASA 323
Cdd:COG2319  271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 113195628 324 DGTSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVW 372
Cdd:COG2319  351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
86-405 5.71e-97

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 296.05  E-value: 5.71e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  86 RALQAHILPLTNVAFNKSGSCFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFnNPYGDKVATGSFDKTCKLWSAE 165
Cdd:COG2319   30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLA 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 166 TGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAIL 245
Cdd:COG2319  109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 246 WDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASADG 325
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADG 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 326 TSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVWCVKTGACLQVLEGHSDEIFSCAFNYEGDTIITG 405
Cdd:COG2319  269 TVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASG 348
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-372 2.53e-93

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 282.30  E-value: 2.53e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  84 LFRALQAHILPLTNVAFNKSGSCFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFNnPYGDKVATGSFDKTCKLWS 163
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 164 AETGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTA 243
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 244 ILWDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASA 323
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 113195628 324 DGTSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVW 372
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
86-334 1.62e-88

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 274.10  E-value: 1.62e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  86 RALQAHILPLTNVAFNKSGSCFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFNnPYGDKVATGSFDKTCKLWSAE 165
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-PDGKLLASGSADGTVRLWDLA 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 166 TGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAIL 245
Cdd:COG2319  235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 246 WDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASADG 325
Cdd:COG2319  315 WDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADG 394


                 ....*....
gi 113195628 326 TSRVFSTDT 334
Cdd:COG2319  395 TVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 126-405 2.31e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 267.28  E-value: 2.31e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 126 ELHTLEGHRNVVYAIAFNnPYGDKVATGSFDKTCKLWSAETGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWD 205
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 206 VESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAILWDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSC 285
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 286 KVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASADGTSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASV 365
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 113195628 366 DKTSRVWCVKTGACLQVLEGHSDEIFSCAFNYEGDTIITG 405
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-331 1.27e-80

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 249.94  E-value: 1.27e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  84 LFRALQAHILPLTNVAFNKSGSCFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFNnPYGDKVATGSFDKTCKLWS 163
Cdd:cd00200   43 LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWD 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 164 AETGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTA 243
Cdd:cd00200  122 VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTI 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 244 ILWDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASA 323
Cdd:cd00200  202 KLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281


                 ....*...
gi 113195628 324 DGTSRVFS 331
Cdd:cd00200  282 DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
109-407 1.93e-80

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 253.29  E-value: 1.93e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 109 TGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFNnPYGDKVATGSFDKTCKLWSAETGKCFYTFRGHTAEIVCLAFNPQ 188
Cdd:COG2319   11 AASADLALALLAAALGALLLLLLGLAAAVASLAAS-PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 189 STLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAILWDVPSGRKVHVLSGHRGEISCVQ 268
Cdd:COG2319   90 GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 269 FNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASADGTSRVFSTDTFQCLCQLEGHKGEI 348
Cdd:COG2319  170 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 113195628 349 SKVCFNAQGSRVLTASVDKTSRVWCVKTGACLQVLEGHSDEIFSCAFNYEGDTIITGNY 407
Cdd:COG2319  250 RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308
WD40 COG2319
WD40 repeat [General function prediction only];
147-405 9.86e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.85  E-value: 9.86e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 147 GDKVATGSFDKTCKLWSAETGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLC 226
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 227 FNTTGDRLVTGSFDHTAILWDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEV 306
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 307 LDVCFNYTGQLIATASADGTSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVWCVKTGACLQVLEGH 386
Cdd:COG2319  166 TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH 245

                        250
                 ....*....|....*....
gi 113195628 387 SDEIFSCAFNYEGDTIITG 405
Cdd:COG2319  246 SGSVRSVAFSPDGRLLASG 264
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-289 4.30e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 186.77  E-value: 4.30e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  78 DERKFYLFRALQAHILPLTNVAFNKSGSCFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFnNPYGDKVATGSFDK 157
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSSQDG 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 158 TCKLWSAETGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTG 237
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 113195628 238 SFDHTAILWDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWD 289
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
184-405 1.31e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.48  E-value: 1.31e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 184 AFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAILWDVPSGRKVHVLSGHRGE 263
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 264 ISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASADGTSRVFSTDTFQCLCQLEG 343
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 113195628 344 HKGEISKVCFNAQGSRVLTASVDKTSRVWCVKTGACLQVLEGHSDEIFSCAFNYEGDTIITG 405
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASG 222
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 98-364 4.98e-15

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 77.05  E-value: 4.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  98 VAFNKSGSCFITGSYDRTCKIWDTAS----GEELH----TLEGhRNVVYAIAFNNPYGDKVATGSFDKTCKLWSAETGKC 169
Cdd:PLN00181 489 IGFDRDGEFFATAGVNKKIKIFECESiikdGRDIHypvvELAS-RSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQL 567

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 170 FYTFRGHTAEIVCLAFNPQS-TLVATGSMDTTAKLWDVESGEEVSTLAGHfAEIISLCF-NTTGDRLVTGSFDHTAILWD 247
Cdd:PLN00181 568 VTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQFpSESGRSLAFGSADHKVYYYD 646

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 248 VPSGR-KVHVLSGHRGEISCVQFnWDCSLIATASLDKSCKVWD----AEG--GQCLATLLGHNDEVLDVCFNYTGQLIAT 320
Cdd:PLN00181 647 LRNPKlPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDlsmsISGinETPLHSFMGHTNVKNFVGLSVSDGYIAT 725

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 321 ASAdgTSRVF----------------STDTFQCLcQLEGHKGEISKVCFNAQGSRVLTAS 364
Cdd:PLN00181 726 GSE--TNEVFvyhkafpmpvlsykfkTIDPVSGL-EVDDASQFISSVCWRGQSSTLVAAN 782
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 176-372 4.45e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 61.64  E-value: 4.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 176 HTAEIVC-LAFNPQSTLVATGSMDTTAKLWDVES----GEE----VSTLAGHfAEIISLCFNT-TGDRLVTGSFDHTAIL 245
Cdd:PLN00181 481 NSSNLVCaIGFDRDGEFFATAGVNKKIKIFECESiikdGRDihypVVELASR-SKLSGICWNSyIKSQVASSNFEGVVQV 559

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 246 WDVPSGRKVHVLSGHRGEISCVQFN-WDCSLIATASLDKSCKVWDAEGGQCLATLlghNDEVLDVCFNY---TGQLIATA 321
Cdd:PLN00181 560 WDVARSQLVTEMKEHEKRVWSIDYSsADPTLLASGSDDGSVKLWSINQGVSIGTI---KTKANICCVQFpseSGRSLAFG 636

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 113195628 322 SADgtSRVFSTDTFQ---CLCQLEGHKGEISKVCFnAQGSRVLTASVDKTSRVW 372
Cdd:PLN00181 637 SAD--HKVYYYDLRNpklPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLW 687
PTZ00421 PTZ00421
coronin; Provisional
 215-352 9.23e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 60.29  E-value: 9.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 215 LAGHFAEIISLCFNTTGD-RLVTGSFDHTAILWDVP--------SGRKVHvLSGHRGEISCVQFNWDC-SLIATASLDKS 284
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFDPqKLFTASEDGTIMGWGIPeegltqniSDPIVH-LQGHTKKVGIVSFHPSAmNVLASAGADMV 149

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 113195628 285 CKVWDAEGGQCLATLLGHNDEVLDVCFNYTGQLIATASADGTSRVFSTDTFQCLCQLEGHKGEISKVC 352
Cdd:PTZ00421 150 VNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRC 217
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 166-205 9.81e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 9.81e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 113195628   166 TGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWD 205
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
167-205 2.95e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 2.95e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 113195628  167 GKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWD 205
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 24-280 3.34e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.94  E-value: 3.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  24 QLRTKCI----DLLNLTpetdveELVLEI---RAAEPLITSSCVEQVKLLICklqEKVSqKDERKFYLFRALQAHILPLT 96
Cdd:PLN00181 467 KLRVKADlkqgDLLNSS------NLVCAIgfdRDGEFFATAGVNKKIKIFEC---ESII-KDGRDIHYPVVELASRSKLS 536

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  97 NVAFNKS-GSCFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFNNPYGDKVATGSFDKTCKLWSAETGKCFYTFRG 175
Cdd:PLN00181 537 GICWNSYiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT 616

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 176 hTAEIVCLAFNPQS-TLVATGSMDTTAKLWDVESGE-EVSTLAGHfAEIISLCFNTTGDRLVTGSFDHTAILWDVP---S 250
Cdd:PLN00181 617 -KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKlPLCTMIGH-SKTVSYVRFVDSSTLVSSSTDNTLKLWDLSmsiS 694

                        250       260       270
                 ....*....|....*....|....*....|...
gi 113195628 251 G---RKVHVLSGHRGEISCVQFNWDCSLIATAS 280
Cdd:PLN00181 695 GineTPLHSFMGHTNVKNFVGLSVSDGYIATGS 727
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 250-289 8.21e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 8.21e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 113195628   250 SGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWD 289
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 271-404 2.64e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 55.67  E-value: 2.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 271 WDCS-LIATAslDKSCKV-WDAEGGQC---------LAT----LLGHNDEVLDVCFN-YTGQLIATASADGT-------S 327
Cdd:PTZ00421  30 WDCSnTIACN--DRFIAVpWQQLGSTAvlkhtdygkLASnppiLLGQEGPIIDVAFNpFDPQKLFTASEDGTimgwgipE 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 113195628 328 RVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVL-TASVDKTSRVWCVKTGACLQVLEGHSDEIFSCAFNYEGDTIIT 404
Cdd:PTZ00421 108 EGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCT 185
WD40 pfam00400
WD domain, G-beta repeat;
251-289 5.20e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 5.20e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 113195628  251 GRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWD 289
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-163 2.36e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.36e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 113195628   123 SGEELHTLEGHRNVVYAIAFNnPYGDKVATGSFDKTCKLWS 163
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 132-290 4.56e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.82  E-value: 4.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 132 GHRNVVYAIAFNnPYGD-KVATGSFDKTCKLW-------SAETGKCFYTFRGHTAEIVCLAFNPQSTLV-ATGSMDTTAK 202
Cdd:PTZ00421  73 GQEGPIIDVAFN-PFDPqKLFTASEDGTIMGWgipeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMNVlASAGADMVVN 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 203 LWDVESGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAILWDVPSGRKVHVLSGHRGEIS--CVqfnWdC---SLIA 277
Cdd:PTZ00421 152 VWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCL---W-AkrkDLII 227

                        170
                 ....*....|....*..
gi 113195628 278 TASLDKS----CKVWDA 290
Cdd:PTZ00421 228 TLGCSKSqqrqIMLWDT 244
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 293-331 6.94e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.94e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 113195628   293 GQCLATLLGHNDEVLDVCFNYTGQLIATASADGTSRVFS 331
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
124-163 6.98e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 6.98e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 113195628  124 GEELHTLEGHRNVVYAIAFNnPYGDKVATGSFDKTCKLWS 163
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 208-247 8.53e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 8.53e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 113195628   208 SGEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAILWD 247
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
293-331 1.79e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.79e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 113195628  293 GQCLATLLGHNDEVLDVCFNYTGQLIATASADGTSRVFS 331
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 94-248 3.46e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.12  E-value: 3.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  94 PLTNVAFNK-SGSCFITGSYDRTCKIWD-------TASGEELHTLEGHRNVVYAIAFNNPYGDKVATGSFDKTCKLWSAE 165
Cdd:PTZ00421  77 PIIDVAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVE 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 166 TGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAE-------------IISLCFNTTGD 232
Cdd:PTZ00421 157 RGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksqrclwakrkdlIITLGCSKSQQ 236

                        170
                 ....*....|....*.
gi 113195628 233 RlvtgsfdhTAILWDV 248
Cdd:PTZ00421 237 R--------QIMLWDT 244
WD40 pfam00400
WD domain, G-beta repeat;
209-247 3.49e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.49e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 113195628  209 GEEVSTLAGHFAEIISLCFNTTGDRLVTGSFDHTAILWD 247
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 334-372 4.10e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.10e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 113195628   334 TFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVW 372
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 88-120 1.82e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.82e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 113195628    88 LQAHILPLTNVAFNKSGSCFITGSYDRTCKIWD 120
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 226-404 2.03e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 2.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 226 CFNTTG--DRLVT---GSFDHTAILWDVPSGRKVH---VLSGHRGEISCVQFN-WDCSLIATASLDKSCKVWD--AEGGQ 294
Cdd:PTZ00421  32 CSNTIAcnDRFIAvpwQQLGSTAVLKHTDYGKLASnppILLGQEGPIIDVAFNpFDPQKLFTASEDGTIMGWGipEEGLT 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 295 C-----LATLLGHNDEVLDVCFNYTGQ-LIATASADGTSRVFSTDTFQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKT 368
Cdd:PTZ00421 112 QnisdpIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKK 191

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 113195628 369 SRVWCVKTGACLQVLEGH-SDEIFSCAFNYEGDTIIT 404
Cdd:PTZ00421 192 LNIIDPRDGTIVSSVEAHaSAKSQRCLWAKRKDLIIT 228
PTZ00420 PTZ00420
coronin; Provisional
 173-303 3.11e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 3.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 173 FRGHTAEIVCLAFNP-QSTLVATGSMDTTAKLWDV----ESGEEVS----TLAGHFAEIISLCFNTTGDRLVTGS-FDHT 242
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIphndESVKEIKdpqcILKGHKKKISIIDWNPMNYYIMCSSgFDSF 149

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 113195628 243 AILWDVPSGRKVHVLSGHRgEISCVQFNWDCSLIATASLDKSCKVWDAEGGQCLATLLGHN 303
Cdd:PTZ00420 150 VNIWDIENEKRAFQINMPK-KLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHD 209
WD40 pfam00400
WD domain, G-beta repeat;
86-120 4.43e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 4.43e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 113195628   86 RALQAHILPLTNVAFNKSGSCFITGSYDRTCKIWD 120
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
335-372 6.96e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 6.96e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 113195628  335 FQCLCQLEGHKGEISKVCFNAQGSRVLTASVDKTSRVW 372
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
CEP19 pfam14933
CEP19-like protein; This family includes the centrosomal protein of 19 kDa found in eukaryotes. ...
 4-81 4.62e-04

CEP19-like protein; This family includes the centrosomal protein of 19 kDa found in eukaryotes. In humans, it is encoded for by the gene CEP19 which is also known as C3orf34. These proteins localize in the centrosomes. Centrosomes are dynamic organelles that assemble around the centrioles. They organize the microtubule cytoskeleton and mitotic spindle apparatus and are required for cell division and cell migration. C3orf34 localizes near the centrosome in early interphase, to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase.


Pssm-ID: 373400  Cd Length: 150  Bit Score: 40.38  E-value: 4.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628    4 KRMHIRYYPPGIFLDYEKG--GQLRTKCIDLLNLTPETDVEelvleiRAAEPLITSScveQVKLLICKLQEKVSQKDERK 81
Cdd:pfam14933   1 KKCGIRFQPPALIIFYEDKeaGKLRRRTIPLRNFSKNSDVA------RLAERLKKNP---RHKSYLERVSLLQLEKLIGL 71
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 150-254 7.14e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.60  E-value: 7.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  150 VATGSFDKTCKLWSAETGKCFYTFRGHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGE-----------EVST---- 214
Cdd:pfam20426  97 ISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRssekrsrntqtEFPRkdhv 176

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 113195628  215 --------LAGHFAEIISLCFNTTGDRLVTGSFDHTAILWDVPSGRKV 254
Cdd:pfam20426 177 iaetpfhiLCGHDDIITCLYVSVELDIVISGSKDGTCIFHTLREGRYV 224
PTZ00420 PTZ00420
coronin; Provisional
 130-208 3.05e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628 130 LEGHRNVVYAIAFNNPYGDKVATGSFDKTCKLWS--------AETGKCFYTFRGHTAEIVCLAFNPQST-LVATGSMDTT 200
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEiphndesvKEIKDPQCILKGHKKKISIIDWNPMNYyIMCSSGFDSF 149


                 ....*...
gi 113195628 201 AKLWDVES 208
Cdd:PTZ00420 150 VNIWDIEN 157
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 160-225 6.25e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.72  E-value: 6.25e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113195628  160 KLWSAETGKcfytfrgHTAEIVCLAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISL 225
Cdd:pfam12894  28 RVWTLSPDK-------EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 376-405 7.89e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 7.89e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 113195628   376 TGACLQVLEGHSDEIFSCAFNYEGDTIITG 405
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASG 30
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 292-405 8.42e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.13  E-value: 8.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  292 GGQCLATLLGHNDEVLDVCFNYTGQLIATASADGtsrvfstDTFQCLCQlegHKGEISKVCFNAQGSRVLTASVDKTSRV 371
Cdd:pfam20426  81 GAQCFATLQTPSENFLISCGNWENSFQVISLNDG-------RMVQSIRQ---HKDVVSCVAVTSDGSILATGSYDTTVMV 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 113195628  372 W-----------------------CVKTGACLQVLEGHSDEIFSCAFNYEGDTIITG 405
Cdd:pfam20426 151 WevlrgrssekrsrntqtefprkdHVIAETPFHILCGHDDIITCLYVSVELDIVISG 207
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 183-271 8.97e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.33  E-value: 8.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113195628  183 LAFNPQSTLVATGSmdTTAKLWDVE-SGEEVSTLAGHF--AEIISLCFNTTGDRLVTGSFDHTAILWDVPSGRKVHVLSG 259
Cdd:pfam12894   1 MSWCPTMDLIALAT--EDGELLLHRlNWQRVWTLSPDKedLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSA 78

                          90
                  ....*....|..
gi 113195628  260 HRGEISCVqfNW 271
Cdd:pfam12894  79 GSDLITCL--GW 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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