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Conserved domains on  [gi|113930728|ref|NP_001039020|]
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tubby-related protein 2 isoform 2 [Mus musculus]

Protein Classification

tubby family protein( domain architecture ID 11070239)

tubby (TUB) family protein similar to Mus musculus tubby protein that binds to membranes containing phosphatidylinositol 4,5-bisphosphate and functions in signal transduction from heterotrimeric G protein-coupled receptors; tubby family protein plays an important role in maintenance and function of neuronal cells during post differentiation and development in mammals, and may participate in the abscisic acid (ABA) signaling pathway in plants

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tub pfam01167
Tub family;
315-557 5.69e-131

Tub family;


:

Pssm-ID: 460094  Cd Length: 251  Bit Score: 382.31  E-value: 5.69e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728  315 PAPRDHMVQCRIVRNKHGMdkGMFPSYYLYLE---AEDGVahFLLAGRKRKRSKTSNYLISLDPKDMSRNGSNFVGKVRS 391
Cdd:pfam01167   3 PGPRDGTIQCFIKRDKSGM--GLTPTYHLYLElspGDGGK--FLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728  392 NVLGTKFTIFDN-----GVNPERSYWVPDSARI---REELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRMKVQPQNDq 463
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKVspgRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSE- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728  464 DSILSRVQKGAGHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQIVHPDEPDHLVLQFGRVAPNIFTMDFRYPLC 543
Cdd:pfam01167 158 SSLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237

                         250
                  ....*....|....
gi 113930728  544 PLQAFAICLSSFDG 557
Cdd:pfam01167 238 AFQAFAICLSSFDT 251
Tub_N super family cl24783
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 39-199 1.53e-32

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


The actual alignment was detected with superfamily member pfam16322:

Pssm-ID: 465092  Cd Length: 196  Bit Score: 123.76  E-value: 1.53e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728   39 QQRQLFEKKQRRKRQEPLMVQANPDATLRHRRPRRGEERFQSDSSWGLGVGSPF--LQENVPQAHLPSGAHSALVTMSyv 116
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIyhVQEAAPRSAKRSGAHAALGTQG-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728  117 ADGSGERAPLLSPRGAvytrgngpavrhhlcwlPDSSDSDVEEVTMEDIPVISRPPQTNLANLRRGWLASPG-------- 188
Cdd:pfam16322  79 GDGKGIDGPAAFLTEE-----------------PQDSGSELQILSVGDSPTSPPPDEELQEPGASGEEESSKqdlgdemq 141

                         170
                  ....*....|....*...
gi 113930728  189 -PGIS------QEEKEEE 199
Cdd:pfam16322 142 kKGISssmnfdEEEEDEE 159
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
315-557 5.69e-131

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 382.31  E-value: 5.69e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728  315 PAPRDHMVQCRIVRNKHGMdkGMFPSYYLYLE---AEDGVahFLLAGRKRKRSKTSNYLISLDPKDMSRNGSNFVGKVRS 391
Cdd:pfam01167   3 PGPRDGTIQCFIKRDKSGM--GLTPTYHLYLElspGDGGK--FLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728  392 NVLGTKFTIFDN-----GVNPERSYWVPDSARI---REELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRMKVQPQNDq 463
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKVspgRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSE- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728  464 DSILSRVQKGAGHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQIVHPDEPDHLVLQFGRVAPNIFTMDFRYPLC 543
Cdd:pfam01167 158 SSLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237

                         250
                  ....*....|....
gi 113930728  544 PLQAFAICLSSFDG 557
Cdd:pfam01167 238 AFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 39-199 1.53e-32

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 123.76  E-value: 1.53e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728   39 QQRQLFEKKQRRKRQEPLMVQANPDATLRHRRPRRGEERFQSDSSWGLGVGSPF--LQENVPQAHLPSGAHSALVTMSyv 116
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIyhVQEAAPRSAKRSGAHAALGTQG-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728  117 ADGSGERAPLLSPRGAvytrgngpavrhhlcwlPDSSDSDVEEVTMEDIPVISRPPQTNLANLRRGWLASPG-------- 188
Cdd:pfam16322  79 GDGKGIDGPAAFLTEE-----------------PQDSGSELQILSVGDSPTSPPPDEELQEPGASGEEESSKqdlgdemq 141

                         170
                  ....*....|....*...
gi 113930728  189 -PGIS------QEEKEEE 199
Cdd:pfam16322 142 kKGISssmnfdEEEEDEE 159
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
315-557 5.69e-131

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 382.31  E-value: 5.69e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728  315 PAPRDHMVQCRIVRNKHGMdkGMFPSYYLYLE---AEDGVahFLLAGRKRKRSKTSNYLISLDPKDMSRNGSNFVGKVRS 391
Cdd:pfam01167   3 PGPRDGTIQCFIKRDKSGM--GLTPTYHLYLElspGDGGK--FLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728  392 NVLGTKFTIFDN-----GVNPERSYWVPDSARI---REELGVVCYETNVLGFRGPRKMTVILPGMDSRKQRMKVQPQNDq 463
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKVspgRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSE- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728  464 DSILSRVQKGAGHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASVKNFQIVHPDEPDHLVLQFGRVAPNIFTMDFRYPLC 543
Cdd:pfam01167 158 SSLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237

                         250
                  ....*....|....
gi 113930728  544 PLQAFAICLSSFDG 557
Cdd:pfam01167 238 AFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 39-199 1.53e-32

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 123.76  E-value: 1.53e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728   39 QQRQLFEKKQRRKRQEPLMVQANPDATLRHRRPRRGEERFQSDSSWGLGVGSPF--LQENVPQAHLPSGAHSALVTMSyv 116
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIyhVQEAAPRSAKRSGAHAALGTQG-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930728  117 ADGSGERAPLLSPRGAvytrgngpavrhhlcwlPDSSDSDVEEVTMEDIPVISRPPQTNLANLRRGWLASPG-------- 188
Cdd:pfam16322  79 GDGKGIDGPAAFLTEE-----------------PQDSGSELQILSVGDSPTSPPPDEELQEPGASGEEESSKqdlgdemq 141

                         170
                  ....*....|....*...
gi 113930728  189 -PGIS------QEEKEEE 199
Cdd:pfam16322 142 kKGISssmnfdEEEEDEE 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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