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Conserved domains on  [gi|115511044|ref|NP_001070146|]
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zinc finger protein 493 isoform 3 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 4.58e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 4.58e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115511044    13 LTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLGIAVSKPDLVTCLEQGKDPWN 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-761 5.61e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 5.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 361 SSHLTTHKRIHTGEKPYKC--EECGKAFSIFSTLTKHKIIHTEEKSHRCEECGKAYKES-SHLTTHKRIHTGEKPYKCEE 437
Cdd:COG5048   46 LEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKaSSSSLSSSSSNSNDNNLLSS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 438 CGKTFSVFSILTKHKIIHTEEKPYKCEECGKAFKRSSTLTKHRIIHTeekpyKCEECGKAFNQSSTLSIHKIIHTGEKPY 517
Cdd:COG5048  126 HSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLP-----ANSLSKDPSSNLSLLISSNVSTSIPSSS 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 518 KCEECGKAFKRSSTLTIHKMIHTgEKPYKCEECGKAF----NRSSHLTTHKRIHTGHkpykCKECGKSFSVFSTLTKHKI 593
Cdd:COG5048  201 ENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSpkslLSQSPSSLSSSDSSSS----ASESPRSSLPTASSQSSSP 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 594 IHTD-------KKPYKCEECGKAFNRSSILSIHK--KIHTGE--KPYKCEE--CGKAFKRSSHLAGHKQIHSVQKPYKC- 659
Cdd:COG5048  276 NESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEk 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 660 -EECGKAFSIFST-----LTKHKIIHTEEKPYKCE--KCGKTFYRFSNLNTHKIIHTGEKP--CKCEECGKAFNHSSNLI 729
Cdd:COG5048  356 lLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLI 435

                        410       420       430
                 ....*....|....*....|....*....|..
gi 115511044 730 KHKLIHTGDKPYKCEACGKaFRRSSHLSRHKI 761
Cdd:COG5048  436 PHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 4.58e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 4.58e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115511044    13 LTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLGIAVSKPDLVTCLEQGKDPWN 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-53 3.00e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 3.00e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 115511044   12 PLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLG 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-52 2.77e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 2.77e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 115511044  13 LTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFL 52
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-761 5.61e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 5.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 361 SSHLTTHKRIHTGEKPYKC--EECGKAFSIFSTLTKHKIIHTEEKSHRCEECGKAYKES-SHLTTHKRIHTGEKPYKCEE 437
Cdd:COG5048   46 LEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKaSSSSLSSSSSNSNDNNLLSS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 438 CGKTFSVFSILTKHKIIHTEEKPYKCEECGKAFKRSSTLTKHRIIHTeekpyKCEECGKAFNQSSTLSIHKIIHTGEKPY 517
Cdd:COG5048  126 HSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLP-----ANSLSKDPSSNLSLLISSNVSTSIPSSS 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 518 KCEECGKAFKRSSTLTIHKMIHTgEKPYKCEECGKAF----NRSSHLTTHKRIHTGHkpykCKECGKSFSVFSTLTKHKI 593
Cdd:COG5048  201 ENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSpkslLSQSPSSLSSSDSSSS----ASESPRSSLPTASSQSSSP 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 594 IHTD-------KKPYKCEECGKAFNRSSILSIHK--KIHTGE--KPYKCEE--CGKAFKRSSHLAGHKQIHSVQKPYKC- 659
Cdd:COG5048  276 NESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEk 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 660 -EECGKAFSIFST-----LTKHKIIHTEEKPYKCE--KCGKTFYRFSNLNTHKIIHTGEKP--CKCEECGKAFNHSSNLI 729
Cdd:COG5048  356 lLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLI 435

                        410       420       430
                 ....*....|....*....|....*....|..
gi 115511044 730 KHKLIHTGDKPYKCEACGKaFRRSSHLSRHKI 761
Cdd:COG5048  436 PHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-387 1.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.29e-03
                          10        20
                  ....*....|....*....|....*
gi 115511044  363 HLTTHKRIHTGEKPYKCEECGKAFS 387
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 4.58e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 4.58e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115511044    13 LTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLGIAVSKPDLVTCLEQGKDPWN 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-53 3.00e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 3.00e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 115511044   12 PLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLG 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-52 2.77e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 2.77e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 115511044  13 LTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFL 52
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-761 5.61e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 5.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 361 SSHLTTHKRIHTGEKPYKC--EECGKAFSIFSTLTKHKIIHTEEKSHRCEECGKAYKES-SHLTTHKRIHTGEKPYKCEE 437
Cdd:COG5048   46 LEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKaSSSSLSSSSSNSNDNNLLSS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 438 CGKTFSVFSILTKHKIIHTEEKPYKCEECGKAFKRSSTLTKHRIIHTeekpyKCEECGKAFNQSSTLSIHKIIHTGEKPY 517
Cdd:COG5048  126 HSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLP-----ANSLSKDPSSNLSLLISSNVSTSIPSSS 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 518 KCEECGKAFKRSSTLTIHKMIHTgEKPYKCEECGKAF----NRSSHLTTHKRIHTGHkpykCKECGKSFSVFSTLTKHKI 593
Cdd:COG5048  201 ENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSpkslLSQSPSSLSSSDSSSS----ASESPRSSLPTASSQSSSP 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 594 IHTD-------KKPYKCEECGKAFNRSSILSIHK--KIHTGE--KPYKCEE--CGKAFKRSSHLAGHKQIHSVQKPYKC- 659
Cdd:COG5048  276 NESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEk 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 660 -EECGKAFSIFST-----LTKHKIIHTEEKPYKCE--KCGKTFYRFSNLNTHKIIHTGEKP--CKCEECGKAFNHSSNLI 729
Cdd:COG5048  356 lLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLI 435

                        410       420       430
                 ....*....|....*....|....*....|..
gi 115511044 730 KHKLIHTGDKPYKCEACGKaFRRSSHLSRHKI 761
Cdd:COG5048  436 PHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-667 6.18e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 6.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 262 QKPYKCEECGTSFYQFSYLTRHKLIHTREKPYKCEQYGKTFNQSSTLTG--HKIIHNGEKPYKCEECGKAFSIFSTPTKH 339
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 340 KIIHTEEKSHrCEEYCKAYKESSHLTTHKRIHTGEKPYKCEECGKAFSIFSTLTKHKIIHTeekSHRCEECGKAYKESSH 419
Cdd:COG5048  111 SSSSSNSNDN-NLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPP---LPANSLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 420 LTTHKRIHTGEKPYKCEECGKTFSVFSILTKHKIIHTEEkPYKCEECGKAFKRSSTLTKHRIIHTEEKPYKCEECGKAFN 499
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 500 QSSTLSIHKIIHTGE-------KPYKCEECGKAFKRSSTLTIHK--MIHTGE--KPYKCEE--CGKAFNRSSHLTTHKRI 566
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 567 HTGHKPYKCK--ECGKSFSVFST------LTKHKIIHTDKKPYKCE-ECGKAFNRSSILSIHKKIHTGEKP--YKCEECG 635
Cdd:COG5048  346 HTSISPAKEKllNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                        410       420       430
                 ....*....|....*....|....*....|..
gi 115511044 636 KAFKRSSHLAGHKQIHSVQKPYKCEECGKAFS 667
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-583 5.31e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 5.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 179 KKPFKCKKCGKSFCMLLHLCQHKRIHIRENSYRC--EECGKAFIWFSTLTRHRRVHTGEKSY--KYECGKSFNQDSNLTT 254
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlnSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 255 HKRIHTGQKPYKCEECGTSFYQFSYLTRHKLIHTREKPYKCEQYGKTFNQSSTLTGHKIIHNGEkpykcEECGKAFSIFS 334
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 335 TPTKHKIIHTEEKSHRCEEYCKAYKESSHLTTHKRIHTgEKPYKCEECGKAFSIFSTLTKHKIIHTEEKSHRCEECGKAY 414
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 415 KESSHLTTHKRIHTGE-------KPYKCEECGKTFSVFSILTKHK--IIHTEE--KPYKCEE--CGKAFKRSSTLTKHRI 481
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 482 IHTEEKPYKC--EECGKAFNQSST------LSIHKIIHTGEKPYKCE-ECGKAFKRSSTLTIHKMIHTGEKP--YKCEEC 550
Cdd:COG5048  345 LHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410       420       430
                 ....*....|....*....|....*....|...
gi 115511044 551 GKAFNRSSHLTTHKRIHTGHKPYKCKECGKSFS 583
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
431-765 8.29e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 8.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 431 KPYKCEECGKTFSVFSILTKHKIIHTEEKPYKC--EECGKAFKRSSTLTKHRIIHTEEKPYKCE-ECGKAFNQSSTLSIH 507
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 508 KIIHTGEKPYKCEECGKAFKRSSTLTIHKMIHTGEKPYKCEECGKAFNRSS----------------------HLTTHKR 565
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 566 IHTGHKPYKCKECGKSFSVFSTLTKHKIIHTDKKPYKCEECGKAFNRSSILSIHKKIHTGEKPYKCEECGKAFK--RSSH 643
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 644 LAGHKQIHSVQ-----KPYKCEECGKAFSIFSTLTKHK--IIHTEE--KPYKC--EKCGKTFYRFSNLNTHKIIHTG--E 710
Cdd:COG5048  272 SSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSisP 351

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115511044 711 KPCKCEECGKAFNHSSN-----LIKHKLIHTGDKPYKCE--ACGKAFRRSSHLSRHKIIHIG 765
Cdd:COG5048  352 AKEKLLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLS 413
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
487-766 8.07e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 8.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 487 KPYKCEECGKAFNQSSTLSIHKIIHTGEKPYKC--EECGKAFKRSSTLTIHKMIHTGEKPYKCE-ECGKAFNRSSHLTTH 563
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 564 KRIHTGHKPYKCKECGKSFSVFSTLTKHKIIHTDKKPYKCEECGKAFNRSS----------------------ILSIHKK 621
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 622 IHTGEKPYKCEECGKAFKRSSHLAGHKQIHSVQKPYKCEECGKAF------SIFSTLTKHKIIHTEEKPYKCEKCGKTFY 695
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115511044 696 RFSNLNTHKIIHTG-EKPCKCEECGKAFNHSSNLIKHK--LIHTG--DKPYKC--EACGKAFRRSSHLSRHKIIHIGI 766
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSI 349
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 625-704 7.02e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.33  E-value: 7.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 625 GEKPYKCE--ECGKAFKRSSHLAGHKqIHSVQKPYKCEECGKafsifstlTKHKIIHTEEKPYKCEKCGKtfyRFSNLNT 702
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDK---RYKNLNG 413


                 ..
gi 115511044 703 HK 704
Cdd:COG5189  414 LK 415
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 514-621 6.76e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 6.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 514 EKPYKCEECGKAFKRSSTLTIH---KMIHT-GEKPYKCE--ECGKAFNRSSHLTTHkRIHtGHKPYKCKECGKSfsvfst 587
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPveGCNKKYKNQNGLKYH-MLH-GHQNQKLHENPSP------ 386

                         90       100       110
                 ....*....|....*....|....*....|....
gi 115511044 588 lTKHKIIHTDKKPYKCEECGKAFNRSSILSIHKK 621
Cdd:COG5189  387 -EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 457-536 1.30e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 457 EEKPYKCE--ECGKAFKRSSTLTKHRiihteekpyKCEECGKAFNQSSTLSIHKIIHTGEKPYKCEECGKAFKRSSTLTI 534
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 115511044 535 HK 536
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 373-480 2.22e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 373 GEKPYKCEecgkafsifstltkhkiihteekshrCEECGKAYKESSHLTTHkRIHTGEKPYKCEECGKTfsvfsiltKHK 452
Cdd:COG5189  346 DGKPYKCP--------------------------VEGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMN 390

                         90       100
                 ....*....|....*....|....*...
gi 115511044 453 IIHTEEKPYKCEECGKAFKRSSTLTKHR 480
Cdd:COG5189  391 IFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 681-760 4.55e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 4.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511044 681 EEKPYKCE--KCGKTFYRFSNLNTHKiihtgekpcKCEECGKAFNHSSNLIKHKLIHTGDKPYKCEACGKAFRRSSHLSR 758
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 115511044 759 HK 760
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-387 1.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.29e-03
                          10        20
                  ....*....|....*....|....*
gi 115511044  363 HLTTHKRIHTGEKPYKCEECGKAFS 387
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
419-443 1.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.74e-03
                          10        20
                  ....*....|....*....|....*
gi 115511044  419 HLTTHKRIHTGEKPYKCEECGKTFS 443
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
559-583 2.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.20e-03
                          10        20
                  ....*....|....*....|....*
gi 115511044  559 HLTTHKRIHTGHKPYKCKECGKSFS 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
616-640 2.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.22e-03
                          10        20
                  ....*....|....*....|....*
gi 115511044  616 LSIHKKIHTGEKPYKCEECGKAFKR 640
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 513-570 2.24e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115511044 513 GEKPYKCE--ECGKAFKRSSTLTIHKM-------------------IHTGEKPYKCEECGKAFNRSSHLTTHkRIHTGH 570
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
504-528 5.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.76e-03
                          10        20
                  ....*....|....*....|....*
gi 115511044  504 LSIHKIIHTGEKPYKCEECGKAFKR 528
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
448-472 8.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.71e-03
                          10        20
                  ....*....|....*....|....*
gi 115511044  448 LTKHKIIHTEEKPYKCEECGKAFKR 472
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG2331 COG2331
Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction ...
 433-472 9.10e-03

Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only];


Pssm-ID: 441902  Cd Length: 77  Bit Score: 35.79  E-value: 9.10e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 115511044 433 YKCEECGKTFSVFsiltkHKIihTEEKPYKCEECGKAFKR 472
Cdd:COG2331    6 YRCESCGHEFEVL-----QKM--SDDPLTVCPECGGPLRR 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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