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Conserved domains on  [gi|117676370|ref|NP_001071122|]
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tumor necrosis factor alpha-induced protein 8 isoform b [Homo sapiens]

Protein Classification

TNFAIP8 family protein( domain architecture ID 10527599)

tumor necrosis factor alpha-induced protein 8 (TNFAIP8) family protein is a DUF758 domain-containing protein similar to vertebrate TNFAIP8 that acts as a negative mediator of apoptosis and may play a role in tumor progression

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF758 pfam05527
Domain of unknown function (DUF758); Family of eukaryotic proteins with unknown function, ...
27-186 1.64e-89

Domain of unknown function (DUF758); Family of eukaryotic proteins with unknown function, which are induced by tumour necrosis factor.


:

Pssm-ID: 461672  Cd Length: 160  Bit Score: 259.04  E-value: 1.64e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676370   27 SIATTLIDDTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSF 106
Cdd:pfam05527   1 SVAKLFIDDTSSELLDNLYRLAKEYTGNKKEAEKVVKNLIKIVVKVGVLYRNNQFSAEELALLEKFRRKFHQLAMTAISF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676370  107 HQVDYTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKPHLQKLCDGINKMLDEE 186
Cdd:pfam05527  81 YEVDFTFDKAVLAALLKECRDLLLQLVERHLTPKSHGRINHVFDFFADPEFLDALFSPDGPYREHLGKICDDLNKLLDEG 160
 
Name Accession Description Interval E-value
DUF758 pfam05527
Domain of unknown function (DUF758); Family of eukaryotic proteins with unknown function, ...
27-186 1.64e-89

Domain of unknown function (DUF758); Family of eukaryotic proteins with unknown function, which are induced by tumour necrosis factor.


Pssm-ID: 461672  Cd Length: 160  Bit Score: 259.04  E-value: 1.64e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676370   27 SIATTLIDDTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSF 106
Cdd:pfam05527   1 SVAKLFIDDTSSELLDNLYRLAKEYTGNKKEAEKVVKNLIKIVVKVGVLYRNNQFSAEELALLEKFRRKFHQLAMTAISF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676370  107 HQVDYTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKPHLQKLCDGINKMLDEE 186
Cdd:pfam05527  81 YEVDFTFDKAVLAALLKECRDLLLQLVERHLTPKSHGRINHVFDFFADPEFLDALFSPDGPYREHLGKICDDLNKLLDEG 160
 
Name Accession Description Interval E-value
DUF758 pfam05527
Domain of unknown function (DUF758); Family of eukaryotic proteins with unknown function, ...
27-186 1.64e-89

Domain of unknown function (DUF758); Family of eukaryotic proteins with unknown function, which are induced by tumour necrosis factor.


Pssm-ID: 461672  Cd Length: 160  Bit Score: 259.04  E-value: 1.64e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676370   27 SIATTLIDDTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSF 106
Cdd:pfam05527   1 SVAKLFIDDTSSELLDNLYRLAKEYTGNKKEAEKVVKNLIKIVVKVGVLYRNNQFSAEELALLEKFRRKFHQLAMTAISF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676370  107 HQVDYTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKPHLQKLCDGINKMLDEE 186
Cdd:pfam05527  81 YEVDFTFDKAVLAALLKECRDLLLQLVERHLTPKSHGRINHVFDFFADPEFLDALFSPDGPYREHLGKICDDLNKLLDEG 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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