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mesoderm induction early response protein 1 isoform d [Homo sapiens]
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
SANT_MTA3_like | cd11661 | Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ... |
305-349 | 1.04e-22 | ||
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis. : Pssm-ID: 212559 [Multi-domain] Cd Length: 46 Bit Score: 90.37 E-value: 1.04e-22
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MIER1_3_C super family | cl44847 | Mesoderm induction early response protein 1/3 C-terminal; This domain is found at the ... |
359-424 | 3.96e-13 | ||
Mesoderm induction early response protein 1/3 C-terminal; This domain is found at the C-terminal of MIER1 and MIER3. MIER1 is a transcriptional repressor that regulates the expression of a number of genes including SP1 target genes, recruiting histone deacetylase 1 (HDAC1) through its ELM2 domain. It has two isoforms, alpha and beta, which differ in their C-terminal domains, both of them being able to interact with HDAC1. The gene encoding MIER3 has been identified as a candidate cancer susceptibility gene. MIER1 and 3 share two regions of high homology, one at the N-terminal and the second at the C-terminal, represented in this entry, which includes a short region located immediately downstream of the SANT extension that is 84% identical. The actual alignment was detected with superfamily member pfam19426: Pssm-ID: 437258 Cd Length: 217 Bit Score: 68.39 E-value: 3.96e-13
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ELM2 | pfam01448 | ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ... |
199-248 | 2.46e-10 | ||
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain. : Pssm-ID: 460214 Cd Length: 53 Bit Score: 55.70 E-value: 2.46e-10
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Name | Accession | Description | Interval | E-value | ||
SANT_MTA3_like | cd11661 | Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ... |
305-349 | 1.04e-22 | ||
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis. Pssm-ID: 212559 [Multi-domain] Cd Length: 46 Bit Score: 90.37 E-value: 1.04e-22
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MIER1_3_C | pfam19426 | Mesoderm induction early response protein 1/3 C-terminal; This domain is found at the ... |
359-424 | 3.96e-13 | ||
Mesoderm induction early response protein 1/3 C-terminal; This domain is found at the C-terminal of MIER1 and MIER3. MIER1 is a transcriptional repressor that regulates the expression of a number of genes including SP1 target genes, recruiting histone deacetylase 1 (HDAC1) through its ELM2 domain. It has two isoforms, alpha and beta, which differ in their C-terminal domains, both of them being able to interact with HDAC1. The gene encoding MIER3 has been identified as a candidate cancer susceptibility gene. MIER1 and 3 share two regions of high homology, one at the N-terminal and the second at the C-terminal, represented in this entry, which includes a short region located immediately downstream of the SANT extension that is 84% identical. Pssm-ID: 437258 Cd Length: 217 Bit Score: 68.39 E-value: 3.96e-13
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ELM2 | pfam01448 | ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ... |
199-248 | 2.46e-10 | ||
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain. Pssm-ID: 460214 Cd Length: 53 Bit Score: 55.70 E-value: 2.46e-10
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SANT | smart00717 | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
305-350 | 3.61e-07 | ||
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 46.45 E-value: 3.61e-07
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Myb_DNA-binding | pfam00249 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
305-348 | 5.85e-05 | ||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 40.18 E-value: 5.85e-05
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Name | Accession | Description | Interval | E-value | ||
SANT_MTA3_like | cd11661 | Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ... |
305-349 | 1.04e-22 | ||
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis. Pssm-ID: 212559 [Multi-domain] Cd Length: 46 Bit Score: 90.37 E-value: 1.04e-22
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MIER1_3_C | pfam19426 | Mesoderm induction early response protein 1/3 C-terminal; This domain is found at the ... |
359-424 | 3.96e-13 | ||
Mesoderm induction early response protein 1/3 C-terminal; This domain is found at the C-terminal of MIER1 and MIER3. MIER1 is a transcriptional repressor that regulates the expression of a number of genes including SP1 target genes, recruiting histone deacetylase 1 (HDAC1) through its ELM2 domain. It has two isoforms, alpha and beta, which differ in their C-terminal domains, both of them being able to interact with HDAC1. The gene encoding MIER3 has been identified as a candidate cancer susceptibility gene. MIER1 and 3 share two regions of high homology, one at the N-terminal and the second at the C-terminal, represented in this entry, which includes a short region located immediately downstream of the SANT extension that is 84% identical. Pssm-ID: 437258 Cd Length: 217 Bit Score: 68.39 E-value: 3.96e-13
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ELM2 | pfam01448 | ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ... |
199-248 | 2.46e-10 | ||
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain. Pssm-ID: 460214 Cd Length: 53 Bit Score: 55.70 E-value: 2.46e-10
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SANT | cd00167 | 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ... |
305-348 | 7.74e-08 | ||
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA. Pssm-ID: 238096 [Multi-domain] Cd Length: 45 Bit Score: 48.34 E-value: 7.74e-08
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SANT | smart00717 | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
305-350 | 3.61e-07 | ||
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 46.45 E-value: 3.61e-07
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Myb_DNA-binding | pfam00249 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
305-348 | 5.85e-05 | ||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 40.18 E-value: 5.85e-05
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Blast search parameters | ||||
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