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Conserved domains on  [gi|118344608|ref|NP_001072086|]
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T-cell surface glycoprotein CD8 alpha chain [Takifugu rubripes]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10058136)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and pattern recognition; similar to Homo sapiens T cell receptor beta variable 30

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 28-123 4.49e-11

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


:

Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.73  E-value: 4.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118344608  28 VVKEGAQVDIHCQPSQAASMTV--WFRVRDNSWMEFIGSFSNGLKKTENNVSSEFThGKINRD---ILTLKSFQRQkDSG 102
Cdd:cd00099    9 SVQEGESVTLSCEVSSSFSSTYiyWYRQKPGQGPEFLIYLSSSKGKTKGGVPGRFS-GSRDGTssfSLTISNLQPE-DSG 86

                         90       100
                 ....*....|....*....|...
gi 118344608 103 LYCCASLYKGK--ELRFGPVTQL 123
Cdd:cd00099   87 TYYCAVSESGGtdKLTFGSGTRL 109
 
Name Accession Description Interval E-value
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 28-123 4.49e-11

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.73  E-value: 4.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118344608  28 VVKEGAQVDIHCQPSQAASMTV--WFRVRDNSWMEFIGSFSNGLKKTENNVSSEFThGKINRD---ILTLKSFQRQkDSG 102
Cdd:cd00099    9 SVQEGESVTLSCEVSSSFSSTYiyWYRQKPGQGPEFLIYLSSSKGKTKGGVPGRFS-GSRDGTssfSLTISNLQPE-DSG 86

                         90       100
                 ....*....|....*....|...
gi 118344608 103 LYCCASLYKGK--ELRFGPVTQL 123
Cdd:cd00099   87 TYYCAVSESGGtdKLTFGSGTRL 109
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 29-124 7.28e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 35.13  E-value: 7.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118344608   29 VKEGAQVDIHCQ-PSQAASMTV---WFRVRDN---SWMEFIGSFSNGLKKTENNVSseFTHGKINRDI-LTLKSFQRQkD 100
Cdd:pfam07686   8 VALGGSVTLPCTySSSMSEASTsvyWYRQPPGkgpTFLIAYYSNGSEEGVKKGRFS--GRGDPSNGDGsLTIQNLTLS-D 84

                          90       100
                  ....*....|....*....|....
gi 118344608  101 SGLYCCASLYKGkELRFGPVTQLR 124
Cdd:pfam07686  85 SGTYTCAVIPSG-EGVFGKGTRLT 107
 
Name Accession Description Interval E-value
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 28-123 4.49e-11

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.73  E-value: 4.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118344608  28 VVKEGAQVDIHCQPSQAASMTV--WFRVRDNSWMEFIGSFSNGLKKTENNVSSEFThGKINRD---ILTLKSFQRQkDSG 102
Cdd:cd00099    9 SVQEGESVTLSCEVSSSFSSTYiyWYRQKPGQGPEFLIYLSSSKGKTKGGVPGRFS-GSRDGTssfSLTISNLQPE-DSG 86

                         90       100
                 ....*....|....*....|...
gi 118344608 103 LYCCASLYKGK--ELRFGPVTQL 123
Cdd:cd00099   87 TYYCAVSESGGtdKLTFGSGTRL 109
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 28-128 4.23e-09

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 52.28  E-value: 4.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118344608  28 VVKEGAQVDIHCQPSQAASMTVWFRVRDNSWMEFIGSFSNGLKKTENNVS-SEFTHGKINRDI--LTLKSFQrQKDSGLY 104
Cdd:cd05899    9 IKRRGQSVTLRCSQKSGHDNMYWYRQDPGKGLQLLFYSYGGGLNEEGDLPgDRFSASRPSLTRssLTIKSAE-PEDSAVY 87

                         90       100
                 ....*....|....*....|....*.
gi 118344608 105 CCASLYKGK--ELRFGPVTQLrgeTV 128
Cdd:cd05899   88 LCASSLGGGadEAYFGPGTRL---TV 110
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 29-124 7.28e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 35.13  E-value: 7.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118344608   29 VKEGAQVDIHCQ-PSQAASMTV---WFRVRDN---SWMEFIGSFSNGLKKTENNVSseFTHGKINRDI-LTLKSFQRQkD 100
Cdd:pfam07686   8 VALGGSVTLPCTySSSMSEASTsvyWYRQPPGkgpTFLIAYYSNGSEEGVKKGRFS--GRGDPSNGDGsLTIQNLTLS-D 84

                          90       100
                  ....*....|....*....|....
gi 118344608  101 SGLYCCASLYKGkELRFGPVTQLR 124
Cdd:pfam07686  85 SGTYTCAVIPSG-EGVFGKGTRLT 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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