BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 122937327 166 AGPAVGWYHYAVGTGDEALRESCLQFLAWNLSAVAASTEWGAVSPELLWQLLQRSDLVLQDELELFHALEAWL 238
Cdd:cd18493    2 VNHAVSWLQYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 122937327 166 AGPAVGWYHYAVGTGDEALRESCLQFLAWNLSAVAASTEWGAVSPELLWQLLQRSDLVLQDELELFHALEAWL 238
Cdd:cd18493    2 VNHAVSWLQYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327   169 AVGWYHYAVGTGDEALRESCLQFLAWNLSAVAASTEWGAVSPELLWQLLQRSDLVLQDELELFHALEAWLGRARPP-PAV 247
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKrREH 80

                           90       100
                   ....*....|....*....|
gi 122937327   248 AERALRAIRYPMIPPAQLFQ 267
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327    64 DVVLRVqaagtdEVRVFHAHRLLLGLHSELFLELLSNQ-SEAVLQE---PQDCAAVFDKFIRYLYCGELTVLLTQAIPLH 139
Cdd:smart00225   1 DVTLVV------GGKKFHAHKAVLAAHSPYFKALFSSDfKESDKSEiylDDVSPEDFRALLNFLYTGKLDLPEENVEELL 74

                           90       100
                   ....*....|....*....|...
gi 122937327   140 RLATKYGVSSLQRGVADYMRAHL 162
Cdd:smart00225  75 ELADYLQIPGLVELCEEFLLKLL 97

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 122937327 166 AGPAVGWYHYAVGTGDEALRESCLQFLAWNLSAVAASTEWGAVSPELLWQLLQRSDLVLQDELELFHALEAWL 238
Cdd:cd18493    2 VNHAVSWLQYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327  169 AVGWYHYAVGTGDEALRESCLQFLAWNLSAVAASTEWGAVSPELLWQLLQRSDLVLQDELELFHALEAWLGRARPP-PAV 247
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERrKKH 80

                          90       100
                  ....*....|....*....|...
gi 122937327  248 AERALRAIRYPMIPPAQLFQLQA 270
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327  43 INHSQAVLQRLQELLRQGNASDVVLRVqaagtDEVRvFHAHRLLLGLHSELFLELL------SNQSEAVLQEPQdcAAVF 116
Cdd:cd18287    3 IDHVHFLSEDIGALFLNEEYSDVTFVV-----EEKR-FPAHRVILAARSEYFRALLyggmreSQQSEIELKDTN--AEAF 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 122937327 117 DKFIRYLYCGELTV-LLTQAIPLH--RLATKYGVSSLQRGVADY 157
Cdd:cd18287   75 KALLKYIYTGRLTLtDLKEDVLLDvlGLAHQYGFEELEAAISDY 118

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327   53 LQELLRQGNASDVVLRVQAagtdevRVFHAHRLLLGLHSELFLELLSNQSEAVLQ---EPQDC-AAVFDKFIRYLYCGEL 128
Cdd:pfam00651   1 LNELREQGELCDVTLVVGD------KEFRAHKAVLAACSPYFKALFSGQESESSVseiTLDDVsPEDFEALLEFMYTGKL 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 122937327  129 tVLLTQAIPLHRLATKYGVSSLQRGVADYMRAHL 162
Cdd:pfam00651  75 -ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327    64 DVVLRVqaagtdEVRVFHAHRLLLGLHSELFLELLSNQ-SEAVLQE---PQDCAAVFDKFIRYLYCGELTVLLTQAIPLH 139
Cdd:smart00225   1 DVTLVV------GGKKFHAHKAVLAAHSPYFKALFSSDfKESDKSEiylDDVSPEDFRALLNFLYTGKLDLPEENVEELL 74

                           90       100
                   ....*....|....*....|...
gi 122937327   140 RLATKYGVSSLQRGVADYMRAHL 162
Cdd:smart00225  75 ELADYLQIPGLVELCEEFLLKLL 97

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327  53 LQELLRQGNASDVVLRVQAagtdevRVFHAHRLLLGLHSELFLELLS----NQSEAVLQEPQDCAAVFDKFIRYLYCGEL 128
Cdd:cd18295   10 LRRLLEQGSYSDVTFNVHG------ESFPAHRCILSARSPYFAEMFEtkwkDKREINLKHPLVNPDAFRALLQYLYTGRL 83

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 122937327 129 TVLLTQAIPLHRLATKYGVSSLQRGVADYMRAHLA 163
Cdd:cd18295   84 EIHVDDVEDCKRLAKQCRLEELIEELEAKCKKVRE 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327  63 SDVVLRVqaagtdEVRVFHAHRLLLGLHSELFLELLSN----QSEAVLQEPQDCAAVFDKFIRYLYCG---ELTVLLTQA 135
Cdd:cd18297   13 SDVTFLV------EGRPFYAHKIVLVTASDRFKSMLSSgsteAQTPVIEIPDIRYDIFQLMMQYLYTGgveSLDVAQDDA 86

                         90
                 ....*....|....*..
gi 122937327 136 IPLHRLATKYGVSSLQR 152
Cdd:cd18297   87 LELLRAASFFQLDGLKR 103

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 122937327  53 LQELLRQGNASDVVLRVQaagtDEVRVFhAHRLLLGLHSELFLELLSNQSeAVLQEPQDCAAVFDKFIRYLYCGELT 129
Cdd:cd18299    3 LRNLLHSPSCADVVFILQ----GGVRIF-AHRIVLAAASSVFADLFLMMT-VVTLDSDITPEAFRRVLEFLYTGVLD 73

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; The GCL protein is a nuclear envelope protein highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in Drosophila embryos. Both human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L) may function in spermatogenesis. They may also be substrate-specific adaptors of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 122937327 170 VGWYHYAVGT-GDEALRESCLQFLAWNLSAVAASTEWGAVSPELLWQLLQRSDL-VLQDELELFHALEAWL 238
Cdd:cd18495    6 VCSYYEAACMyGLTEVKKKCLEWLLRNLMTSQNVTLLRELSIELMEQLIASPNLfVMQVEMDVYTLLKKWL 76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327  45 HSQAVLQRLQELLRQGNASDVVLRVqaagtdEVRVFHAHRLLLGLHSELFLELLSNQSEAVLQEPQDCAAVFDKFIRYLY 124
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDV------GGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAEVFGLLLDFFY 74

                 ....
gi 122937327 125 CGEL 128
Cdd:cd18232   75 TGEL 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327  44 NHSQAVLQRLQELLRQGNASDVVLRVQAagtdevRVFHAHRLLLGLHSEL--------FLELLSNQSEAVLQEPqdcaAV 115
Cdd:cd18259   14 SHPQSILDGLQTLRSNPKLSDVTLLVGG------REFPCHRSVLALCSHYfnamftgdFVESISARVEIKDVDP----AV 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 122937327 116 FDKFIRYLYCGELTVLLTQAIPLHRLATKYGVSSLQRGVADYMRAHL 162
Cdd:cd18259   84 MESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQI 130

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327  45 HSQAVLQRLQELLRQGNASDVVLRVqaagtdEVRVFHAHRLLLGLHSELFLELLSN------QSEAVLQEPQdcAAVFDK 118
Cdd:cd18242    4 HAKSILNTMNSLRKSNTLCDVTLRV------EGKEFPAHRIVLAACSDYFCAMFTSemsekgKSEVELQGLT--ASTMEI 75

                         90
                 ....*....|..
gi 122937327 119 FIRYLYCGELTV 130
Cdd:cd18242   76 LLDFVYTETVHV 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327  45 HSQAVLQRLQELLRQGNASDVVLRVQAagtdevRVFHAHRLLLGLHSELF-----LELLSNQSEAVLQEPQdcaaVFDKF 119
Cdd:cd18220    8 YSNTVLSQLNELRLQGKLCDIIVHIQG------QPFRAHKAVLAASSPYFrdhsaLSTMSGLSISVIKNPN----VFEQL 77

                         90
                 ....*....|....*..
gi 122937327 120 IRYLYCGELTVLLTQAI 136
Cdd:cd18220   78 LSFCYTGRMSLQLKDVV 94

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327 184 LRESCLQFLAWNLSAVAASTEWGAVSPELLWQLLQRSDLVLQDELELFHALEAWLGRARpppavAERA------LRAIRY 257
Cdd:cd18457   21 LVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDR-----ENREeylpelLSKVRL 95

                 ....*
gi 122937327 258 PMIPP 262
Cdd:cd18457   96 PLLRP 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327  45 HSQAVLQRLQELLRQGNASDVVLRVqaagtDEVRVFHAHRLLLGLHSELFLELL-SNQSEAVLQEPQDC---AAVFDKFI 120
Cdd:cd18274    5 HACSILQQLKAMYDEGQLTDIVVEV-----DHGKTFSCHRNVLAAISPYFRSMFtSGLTESTQKEVRIVgveAESMHLVL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 122937327 121 RYLYCGELTVLLTQAIPLHRLATKYGVSSLQRGVADYMRAHL 162
Cdd:cd18274   80 DYAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRL 121

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 122937327 176 AVGTGDEALRESCLQFLAWNLSAVAASTEWGAVSPELLWQLLQrSDLVLQDELELFHALEAW 237
Cdd:cd18494   12 AVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILR-SDKLRIDELDILKAVREW 72

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327  48 AVLQRLQELLRQGNASDVVLRVQAagtdevRVFHAHRLLLGLHSELFLE--LLSNQSEAVLQEPQDCAAvFDKFIRYLYC 125
Cdd:cd18210    7 SLLESLNQQRMEGKLCDISIHVQG------RVFRAHRAVLAASSPYFHDqvLLKNMSSISLPGVMDPGA-FESVLASAYT 79

                 ....*.
gi 122937327 126 GELTVL 131
Cdd:cd18210   80 GKLTML 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937327  41 TSINHSQAVLQRLQEL-LRQGNASDVVLRVqaagtdEVRVFHAHRLLLGLHSELFLELL-SNQSEA---VLQEPQDCAAV 115
Cdd:cd18272   10 TDRSHSSRVAQSIMDLcLEDGLFADVTISV------EGKEFQLHRLVLSAQSCFFRSMFtSNLKEArnrVIELKDVSESV 83

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 122937327 116 FDKFIRYLYCGELTVLLTQAIPLHRLATKYGVSSL 150
Cdd:cd18272   84 FQLLVDYIYHGTVKLRVEELQETYEVADMYQLTAL 118