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Conserved domains on  [gi|124257963|ref|NP_001074394|]
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rap guanine nucleotide exchange factor-like 1 [Mus musculus]

Protein Classification

RasGEF domain-containing protein( domain architecture ID 10639776)

RasGEF domain-containing protein may function as a guanine nucleotide exchange factor for Ras-like small GTPases

CATH:  1.10.840.10
Gene Ontology:  GO:0005085|GO:0007264
PubMed:  10431174|7786285
SCOP:  4001268

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
420-658 6.99e-75

Guanine nucleotide exchange factor for Ras-like small GTPases;


:

Pssm-ID: 214539  Cd Length: 242  Bit Score: 240.22  E-value: 6.99e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963   420 IHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGR-RETANLELLLQRCSEVTHWVATEVLLCEAPGKRVQLLKK 498
Cdd:smart00147   1 LLLLDPKELAEQLTLLDFELFRKIDPSELLGSVWGKRSKKsPSPLNLEAFIRRFNEVSNWVATEILKQTTPKDRAELLSK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963   499 FIKIAAICKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFEGLTDPCRNHKSYREVISKM-KPPLIPFVP 577
Cdd:smart00147  81 FIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLPSKYKKLFEELEELLSPERNYKNYREALSSCnLPPCIPFLG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963   578 LILKDLTFLHEGSKTLV-DGLVNIEKLHSVAEKVRTIRKYRSRPLCldMEASPHHLQtkAYVRQ-FQVIDNQNHLFELSY 655
Cdd:smart00147 161 VLLKDLTFIDEGNPDFLeNGLVNFEKRRQIAEILREIRQLQSQPYN--LRPNRSDIQ--SLLQQlLDHLDEEEELYQLSL 236

                   ...
gi 124257963   656 KLE 658
Cdd:smart00147 237 KIE 239
 
Name Accession Description Interval E-value
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
420-658 6.99e-75

Guanine nucleotide exchange factor for Ras-like small GTPases;


Pssm-ID: 214539  Cd Length: 242  Bit Score: 240.22  E-value: 6.99e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963   420 IHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGR-RETANLELLLQRCSEVTHWVATEVLLCEAPGKRVQLLKK 498
Cdd:smart00147   1 LLLLDPKELAEQLTLLDFELFRKIDPSELLGSVWGKRSKKsPSPLNLEAFIRRFNEVSNWVATEILKQTTPKDRAELLSK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963   499 FIKIAAICKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFEGLTDPCRNHKSYREVISKM-KPPLIPFVP 577
Cdd:smart00147  81 FIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLPSKYKKLFEELEELLSPERNYKNYREALSSCnLPPCIPFLG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963   578 LILKDLTFLHEGSKTLV-DGLVNIEKLHSVAEKVRTIRKYRSRPLCldMEASPHHLQtkAYVRQ-FQVIDNQNHLFELSY 655
Cdd:smart00147 161 VLLKDLTFIDEGNPDFLeNGLVNFEKRRQIAEILREIRQLQSQPYN--LRPNRSDIQ--SLLQQlLDHLDEEEELYQLSL 236

                   ...
gi 124257963   656 KLE 658
Cdd:smart00147 237 KIE 239
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
423-656 2.81e-66

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


Pssm-ID: 238087 [Multi-domain]  Cd Length: 237  Bit Score: 217.51  E-value: 2.81e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963 423 VEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRET-ANLELLLQRCSEVTHWVATEVLLCEAPGKRVQLLKKFIK 501
Cdd:cd00155    4 LDPKELAEQLTLLDFELFRKIEPFELLGSLWSKKDKNIHLsPNLERFIERFNNLSNWVASEILLCTNPKKRARLLSKFIQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963 502 IAAICKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFEGLTDPCRNHKSYREVISKMK--PPLIPFVPLI 579
Cdd:cd00155   84 VAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVLSSKLKKLFEELEELVDPSRNFKNYRKLLKSVGpnPPCVPFLGVY 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124257963 580 LKDLTFLHEGSKTLVD-GLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPHHLQTKayvrQFQVIDNQNHLFELSYK 656
Cdd:cd00155  164 LKDLTFLHEGNPDFLEgNLVNFEKRRKIAEILREIRQLQSNSYELNRDEDILAFLWK----LLELILNEDELYELSLE 237
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
427-604 5.44e-66

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


Pssm-ID: 459872  Cd Length: 179  Bit Score: 214.76  E-value: 5.44e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963  427 DVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRVQLLKKFIKIAAIC 506
Cdd:pfam00617   1 ELARQLTLIEFELFRKIKPRELLGSAWSKKDKKENSPNIEAMIARFNKLSNWVASEILSEEDLKKRAKVIKKFIKIAEHC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963  507 KQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFEGLTDPCRNHKSYREVISKMKPPLIPFVPLILKDLTFL 586
Cdd:pfam00617  81 RELNNFNSLMAILSGLNSSPISRLKKTWELVSKKYKKTLEELEKLMSPSRNFKNYREALSSASPPCIPFLGLYLTDLTFI 160
                         170
                  ....*....|....*....
gi 124257963  587 HEGSKTLV-DGLVNIEKLH 604
Cdd:pfam00617 161 EEGNPDFLeGGLINFEKRR 179
 
Name Accession Description Interval E-value
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
420-658 6.99e-75

Guanine nucleotide exchange factor for Ras-like small GTPases;


Pssm-ID: 214539  Cd Length: 242  Bit Score: 240.22  E-value: 6.99e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963   420 IHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGR-RETANLELLLQRCSEVTHWVATEVLLCEAPGKRVQLLKK 498
Cdd:smart00147   1 LLLLDPKELAEQLTLLDFELFRKIDPSELLGSVWGKRSKKsPSPLNLEAFIRRFNEVSNWVATEILKQTTPKDRAELLSK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963   499 FIKIAAICKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFEGLTDPCRNHKSYREVISKM-KPPLIPFVP 577
Cdd:smart00147  81 FIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLPSKYKKLFEELEELLSPERNYKNYREALSSCnLPPCIPFLG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963   578 LILKDLTFLHEGSKTLV-DGLVNIEKLHSVAEKVRTIRKYRSRPLCldMEASPHHLQtkAYVRQ-FQVIDNQNHLFELSY 655
Cdd:smart00147 161 VLLKDLTFIDEGNPDFLeNGLVNFEKRRQIAEILREIRQLQSQPYN--LRPNRSDIQ--SLLQQlLDHLDEEEELYQLSL 236

                   ...
gi 124257963   656 KLE 658
Cdd:smart00147 237 KIE 239
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
423-656 2.81e-66

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


Pssm-ID: 238087 [Multi-domain]  Cd Length: 237  Bit Score: 217.51  E-value: 2.81e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963 423 VEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRET-ANLELLLQRCSEVTHWVATEVLLCEAPGKRVQLLKKFIK 501
Cdd:cd00155    4 LDPKELAEQLTLLDFELFRKIEPFELLGSLWSKKDKNIHLsPNLERFIERFNNLSNWVASEILLCTNPKKRARLLSKFIQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963 502 IAAICKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFEGLTDPCRNHKSYREVISKMK--PPLIPFVPLI 579
Cdd:cd00155   84 VAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVLSSKLKKLFEELEELVDPSRNFKNYRKLLKSVGpnPPCVPFLGVY 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124257963 580 LKDLTFLHEGSKTLVD-GLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPHHLQTKayvrQFQVIDNQNHLFELSYK 656
Cdd:cd00155  164 LKDLTFLHEGNPDFLEgNLVNFEKRRKIAEILREIRQLQSNSYELNRDEDILAFLWK----LLELILNEDELYELSLE 237
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
427-604 5.44e-66

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


Pssm-ID: 459872  Cd Length: 179  Bit Score: 214.76  E-value: 5.44e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963  427 DVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRVQLLKKFIKIAAIC 506
Cdd:pfam00617   1 ELARQLTLIEFELFRKIKPRELLGSAWSKKDKKENSPNIEAMIARFNKLSNWVASEILSEEDLKKRAKVIKKFIKIAEHC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124257963  507 KQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFEGLTDPCRNHKSYREVISKMKPPLIPFVPLILKDLTFL 586
Cdd:pfam00617  81 RELNNFNSLMAILSGLNSSPISRLKKTWELVSKKYKKTLEELEKLMSPSRNFKNYREALSSASPPCIPFLGLYLTDLTFI 160
                         170
                  ....*....|....*....
gi 124257963  587 HEGSKTLV-DGLVNIEKLH 604
Cdd:pfam00617 161 EEGNPDFLeGGLINFEKRR 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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