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Conserved domains on  [gi|124486710|ref|NP_001074535|]
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DENN domain-containing protein 3 [Mus musculus]

Protein Classification

DENN and dDENN domain-containing protein( domain architecture ID 13071475)

protein containing domains DENN, dDENN, and WD40

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 187-373 3.18e-63

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


:

Pssm-ID: 460461  Cd Length: 186  Bit Score: 213.20  E-value: 3.18e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710   187 FVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDfevDNHIKDFAA-RLSLIPSPPPGPLHLIFNM---KPLQVVFPSRA 262
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPL---PNPIERFIAnLLYEVPFPPPGRTQKLKPLggtEPILLQRPEDS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710   263 DPesPIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSGQMLDFVMA 342
Cdd:pfam02141   78 EL--PLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSA 155

                          170       180       190
                   ....*....|....*....|....*....|.
gi 124486710   343 PTSFLMGCHLDHFEEVRKEADGLVLIDIDHG 373
Cdd:pfam02141  156 PTPFIIGVHSRYFDLLEDPLDDVVLVDLDTG 186
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1021-1274 2.35e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 2.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1021 HCFKVGSSKVNCMVMAEHNQ-VWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTG-LAVHNGKKpseIYSCSLDGTVIAWN 1098
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASADGTY---LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1099 VSTLRVISRFQLSYGDLLSISLHNDR--IWCCTVHKILVV--TPQGFVRQELK-HPKDASFLAFqllPEEQQLWAASTGV 1173
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVwdVETGKCLTTLRgHTDWVNSVAF---SPDGTFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1174 SELYMWSLKDLdqPPQKTYLQDCSEVTCMirvkrqIWVG-GRGLSQGKTRGKIYVMDVEKVTVEKELVAHLDTVRTLCSA 1252
Cdd:cd00200   157 GTIKLWDLRTG--KCVATLTGHTGEVNSV------AFSPdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFS 228

                         250       260
                  ....*....|....*....|..
gi 124486710 1253 EDRYVLSGAGqEEGKIAIWKVE 1274
Cdd:cd00200   229 PDGYLLASGS-EDGTIRVWDLR 249
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 437-499 3.99e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.39  E-value: 3.99e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124486710    437 NCKIQHITLQLLVGIFREVKNHLNY------EHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKAR 499
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
uDENN super family cl04085
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 119-156 3.87e-04

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


The actual alignment was detected with superfamily member pfam03456:

Pssm-ID: 470944  Cd Length: 59  Bit Score: 39.51  E-value: 3.87e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 124486710   119 ALPQLCFPGCVCVASEPKEDYIHFlVLTDVCGNRTYGV 156
Cdd:pfam03456   20 GIPMFCFPEGLETLSSREPTFFSF-VLTDEDGSRLYGA 56
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 187-373 3.18e-63

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 213.20  E-value: 3.18e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710   187 FVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDfevDNHIKDFAA-RLSLIPSPPPGPLHLIFNM---KPLQVVFPSRA 262
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPL---PNPIERFIAnLLYEVPFPPPGRTQKLKPLggtEPILLQRPEDS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710   263 DPesPIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSGQMLDFVMA 342
Cdd:pfam02141   78 EL--PLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSA 155

                          170       180       190
                   ....*....|....*....|....*....|.
gi 124486710   343 PTSFLMGCHLDHFEEVRKEADGLVLIDIDHG 373
Cdd:pfam02141  156 PTPFIIGVHSRYFDLLEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 188-373 5.04e-57

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 195.11  E-value: 5.04e-57
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710    188 VPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDnhikdFAARLSLIPSPPPGPLHLIFNMKPL-QVVFPSRADPES 266
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLE-----LLISLLLYPVPPPGGSLVLVSLGPGdLIELQRPLDSSL 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710    267 PIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSGQMLDFVMAPTSF 346
Cdd:smart00799   76 PLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPF 155

                           170       180
                    ....*....|....*....|....*...
gi 124486710    347 LMGCHLDHFEEVRKEADG-LVLIDIDHG 373
Cdd:smart00799  156 IIGVHSSYFEEVKELPDEdVVVVDLDTG 183
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1021-1274 2.35e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 2.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1021 HCFKVGSSKVNCMVMAEHNQ-VWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTG-LAVHNGKKpseIYSCSLDGTVIAWN 1098
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASADGTY---LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1099 VSTLRVISRFQLSYGDLLSISLHNDR--IWCCTVHKILVV--TPQGFVRQELK-HPKDASFLAFqllPEEQQLWAASTGV 1173
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVwdVETGKCLTTLRgHTDWVNSVAF---SPDGTFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1174 SELYMWSLKDLdqPPQKTYLQDCSEVTCMirvkrqIWVG-GRGLSQGKTRGKIYVMDVEKVTVEKELVAHLDTVRTLCSA 1252
Cdd:cd00200   157 GTIKLWDLRTG--KCVATLTGHTGEVNSV------AFSPdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFS 228

                         250       260
                  ....*....|....*....|..
gi 124486710 1253 EDRYVLSGAGqEEGKIAIWKVE 1274
Cdd:cd00200   229 PDGYLLASGS-EDGTIRVWDLR 249
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 437-499 3.99e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.39  E-value: 3.99e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124486710    437 NCKIQHITLQLLVGIFREVKNHLNY------EHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKAR 499
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
WD40 COG2319
WD40 repeat [General function prediction only];
1006-1274 9.89e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 9.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1006 GKVVVFDASSWTVHQHcFKVGSSKVNCMVM-AEHNQVWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVH-NGKKps 1083
Cdd:COG2319   142 GTVRLWDLATGKLLRT-LTGHSGAVTSVAFsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpDGKL-- 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1084 eIYSCSLDGTVIAWNVSTLRVISRFQLSYGDLLSISLHND--RIWCCTVHKILVV--TPQGFVRQELKHPKDA-SFLAFq 1158
Cdd:COG2319   219 -LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLwdLATGELLRTLTGHSGGvNSVAF- 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1159 lLPEEQQLwAASTGVSELYMWSLKDldQPPQKTYLQDCSEVTCMI--RVKRQIWVGGRGlsqgktrGKIYVMDVEKVTVE 1236
Cdd:COG2319   297 -SPDGKLL-ASGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAfsPDGKTLASGSDD-------GTVRLWDLATGELL 365

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 124486710 1237 KELVAHLDTVRTLC-SAEDRYVLSGAgqEEGKIAIWKVE 1274
Cdd:COG2319   366 RTLTGHTGAVTSVAfSPDGRTLASGS--ADGTVRLWDLA 402
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 119-156 3.87e-04

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 39.51  E-value: 3.87e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 124486710   119 ALPQLCFPGCVCVASEPKEDYIHFlVLTDVCGNRTYGV 156
Cdd:pfam03456   20 GIPMFCFPEGLETLSSREPTFFSF-VLTDEDGSRLYGA 56
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 466-501 1.05e-03

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 37.94  E-value: 1.05e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 124486710   466 FNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLN 501
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLE 36
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1057-1098 2.57e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.57e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 124486710   1057 SMSCNKQLTDHRSPVTGLAVHNGKKpsEIYSCSLDGTVIAWN 1098
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 187-373 3.18e-63

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 213.20  E-value: 3.18e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710   187 FVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDfevDNHIKDFAA-RLSLIPSPPPGPLHLIFNM---KPLQVVFPSRA 262
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPL---PNPIERFIAnLLYEVPFPPPGRTQKLKPLggtEPILLQRPEDS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710   263 DPesPIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSGQMLDFVMA 342
Cdd:pfam02141   78 EL--PLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSA 155

                          170       180       190
                   ....*....|....*....|....*....|.
gi 124486710   343 PTSFLMGCHLDHFEEVRKEADGLVLIDIDHG 373
Cdd:pfam02141  156 PTPFIIGVHSRYFDLLEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 188-373 5.04e-57

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 195.11  E-value: 5.04e-57
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710    188 VPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDnhikdFAARLSLIPSPPPGPLHLIFNMKPL-QVVFPSRADPES 266
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLE-----LLISLLLYPVPPPGGSLVLVSLGPGdLIELQRPLDSSL 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710    267 PIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSGQMLDFVMAPTSF 346
Cdd:smart00799   76 PLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPF 155

                           170       180
                    ....*....|....*....|....*...
gi 124486710    347 LMGCHLDHFEEVRKEADG-LVLIDIDHG 373
Cdd:smart00799  156 IIGVHSSYFEEVKELPDEdVVVVDLDTG 183
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1021-1274 2.35e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 2.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1021 HCFKVGSSKVNCMVMAEHNQ-VWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTG-LAVHNGKKpseIYSCSLDGTVIAWN 1098
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASADGTY---LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1099 VSTLRVISRFQLSYGDLLSISLHNDR--IWCCTVHKILVV--TPQGFVRQELK-HPKDASFLAFqllPEEQQLWAASTGV 1173
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVwdVETGKCLTTLRgHTDWVNSVAF---SPDGTFVASSSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1174 SELYMWSLKDLdqPPQKTYLQDCSEVTCMirvkrqIWVG-GRGLSQGKTRGKIYVMDVEKVTVEKELVAHLDTVRTLCSA 1252
Cdd:cd00200   157 GTIKLWDLRTG--KCVATLTGHTGEVNSV------AFSPdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFS 228

                         250       260
                  ....*....|....*....|..
gi 124486710 1253 EDRYVLSGAGqEEGKIAIWKVE 1274
Cdd:cd00200   229 PDGYLLASGS-EDGTIRVWDLR 249
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 437-499 3.99e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 65.39  E-value: 3.99e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124486710    437 NCKIQHITLQLLVGIFREVKNHLNY------EHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKAR 499
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRElrkepgPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
WD40 COG2319
WD40 repeat [General function prediction only];
1006-1274 9.89e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 9.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1006 GKVVVFDASSWTVHQHcFKVGSSKVNCMVM-AEHNQVWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVH-NGKKps 1083
Cdd:COG2319   142 GTVRLWDLATGKLLRT-LTGHSGAVTSVAFsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpDGKL-- 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1084 eIYSCSLDGTVIAWNVSTLRVISRFQLSYGDLLSISLHND--RIWCCTVHKILVV--TPQGFVRQELKHPKDA-SFLAFq 1158
Cdd:COG2319   219 -LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLwdLATGELLRTLTGHSGGvNSVAF- 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1159 lLPEEQQLwAASTGVSELYMWSLKDldQPPQKTYLQDCSEVTCMI--RVKRQIWVGGRGlsqgktrGKIYVMDVEKVTVE 1236
Cdd:COG2319   297 -SPDGKLL-ASGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAfsPDGKTLASGSDD-------GTVRLWDLATGELL 365

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 124486710 1237 KELVAHLDTVRTLC-SAEDRYVLSGAgqEEGKIAIWKVE 1274
Cdd:COG2319   366 RTLTGHTGAVTSVAfSPDGRTLASGS--ADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
1002-1274 1.62e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 1.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1002 ALNEGKVVVFDASSwTVHQHCFKVGSSKVNCMVMAEHNQVWV-GSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVH-NG 1079
Cdd:COG2319    96 ASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLAsGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSpDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1080 KKpseIYSCSLDGTVIAWNVSTLRVISRFQlsygdllsisLHNDRIWCCTVH---KILVV-----------TPQGFVRQE 1145
Cdd:COG2319   175 KL---LASGSDDGTVRLWDLATGKLLRTLT----------GHTGAVRSVAFSpdgKLLASgsadgtvrlwdLATGKLLRT 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1146 LKHPKDA-SFLAFqlLPEEQQLWAASTGvSELYMWSLKdlDQPPQKTYLQDCSEVTCMIRVK--RQIWVGGRGlsqgktr 1222
Cdd:COG2319   242 LTGHSGSvRSVAF--SPDGRLLASGSAD-GTVRLWDLA--TGELLRTLTGHSGGVNSVAFSPdgKLLASGSDD------- 309

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 124486710 1223 GKIYVMDVEKVTVEKELVAHLDTVRTLC-SAEDRYVLSGAgqEEGKIAIWKVE 1274
Cdd:COG2319   310 GTVRLWDLATGKLLRTLTGHTGAVRSVAfSPDGKTLASGS--DDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
999-1123 5.26e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 5.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710  999 LWCALNEGKVVVFDASSWTVhQHCFKVGSSKVNCMVMAEHNQ-VWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVH 1077
Cdd:COG2319   219 LASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSPDGRlLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 124486710 1078 -NGKKpseIYSCSLDGTVIAWNVSTLRVISRFQLSYGDLLSISLHND 1123
Cdd:COG2319   298 pDGKL---LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1030-1098 8.24e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 8.24e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124486710 1030 VNCmVMAEHNQVWV--GSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVHNGKKpsEIYSCSLDGTVIAWN 1098
Cdd:cd00200   222 VNS-VAFSPDGYLLasGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK--RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1043-1131 9.42e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 9.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1043 VGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVHNGKKpsEIYSCSLDGTVIAWNVSTLRVISRFQlsygdllsisLHN 1122
Cdd:cd00200   194 SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY--LLASGSEDGTIRVWDLRTGECVQTLS----------GHT 261


                  ....*....
gi 124486710 1123 DRIWCCTVH 1131
Cdd:cd00200   262 NSVTSLAWS 270
WD40 COG2319
WD40 repeat [General function prediction only];
1006-1101 2.83e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486710 1006 GKVVVFDASSWTVhQHCFKVGSSKVNCMVMAEHNQ-VWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVH-NGKKps 1083
Cdd:COG2319   310 GTVRLWDLATGKL-LRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpDGRT-- 386

                          90
                  ....*....|....*...
gi 124486710 1084 eIYSCSLDGTVIAWNVST 1101
Cdd:COG2319   387 -LASGSADGTVRLWDLAT 403
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 119-156 3.87e-04

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 39.51  E-value: 3.87e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 124486710   119 ALPQLCFPGCVCVASEPKEDYIHFlVLTDVCGNRTYGV 156
Cdd:pfam03456   20 GIPMFCFPEGLETLSSREPTFFSF-VLTDEDGSRLYGA 56
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 466-501 1.05e-03

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 37.94  E-value: 1.05e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 124486710   466 FNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLN 501
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLE 36
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1057-1098 2.57e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.57e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 124486710   1057 SMSCNKQLTDHRSPVTGLAVHNGKKpsEIYSCSLDGTVIAWN 1098
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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