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Conserved domains on  [gi|124487203|ref|NP_001074634|]
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calcium homeostasis modulator protein 4 [Mus musculus]

Protein Classification

calcium homeostasis modulator protein( domain architecture ID 10632259)

calcium homeostasis modulator protein is a pore-forming subunit of a voltage-gated ion channel that may be permeable to monovalent cations, divalent cations, and anions; it acts as a major ATP release channel, and may have an important role in gustatory signalling and neuronal toxicity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ca_hom_mod pfam14798
Calcium homeostasis modulator; This family of proteins control cytosolic calcium concentration. ...
 14-258 1.17e-80

Calcium homeostasis modulator; This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.


:

Pssm-ID: 464320  Cd Length: 248  Bit Score: 244.85  E-value: 1.17e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487203   14 RSEPCINSLIAILTVCGQQLFSSYTFSCPCQVGKNFYYGSAFLVVPALILLIAGYALRGQMWtvasEYCCCSCTPPYRRS 93
Cdd:pfam14798  13 HKESLGNGLVALLTAGGERIFSSVVFQCPCSPGYNFLYGLVFLLVPALVLFLLGYLLNTRTW----RLLTGCCRPTGKRS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487203   94 spleRRLACL--MFFDITGRALVAPLTWLTVTLLTGTYYECAASEFASVDQypmFANVTPSKREEMLAGFPCYTSAPSDV 171
Cdd:pfam14798  89 ----KRPACLryVFGSITVRALVAPLTWLAVALLDGEFYECAGSEFVDPAK---FLCKTSSCAAEELAKVPCKKSVLPPV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487203  172 IPIRDEVALLHRYQSQMLGWILVVLATIALLLSKCLARCCSPLTSLQHHYWTNHLHNERVLFEKAAEEHSQLLIRHRIKK 251
Cdd:pfam14798 162 DDEREELLRYLRAQSQILGWLLIAVIILLAFLATCLSRCFSPVSYLQLKYWKNYLEKEQELFEETAKEHARQLAKRNVKC 241


                  ....*..
gi 124487203  252 VFGFVPG 258
Cdd:pfam14798 242 FFESSQP 248
 
Name Accession Description Interval E-value
Ca_hom_mod pfam14798
Calcium homeostasis modulator; This family of proteins control cytosolic calcium concentration. ...
 14-258 1.17e-80

Calcium homeostasis modulator; This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.


Pssm-ID: 464320  Cd Length: 248  Bit Score: 244.85  E-value: 1.17e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487203   14 RSEPCINSLIAILTVCGQQLFSSYTFSCPCQVGKNFYYGSAFLVVPALILLIAGYALRGQMWtvasEYCCCSCTPPYRRS 93
Cdd:pfam14798  13 HKESLGNGLVALLTAGGERIFSSVVFQCPCSPGYNFLYGLVFLLVPALVLFLLGYLLNTRTW----RLLTGCCRPTGKRS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487203   94 spleRRLACL--MFFDITGRALVAPLTWLTVTLLTGTYYECAASEFASVDQypmFANVTPSKREEMLAGFPCYTSAPSDV 171
Cdd:pfam14798  89 ----KRPACLryVFGSITVRALVAPLTWLAVALLDGEFYECAGSEFVDPAK---FLCKTSSCAAEELAKVPCKKSVLPPV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487203  172 IPIRDEVALLHRYQSQMLGWILVVLATIALLLSKCLARCCSPLTSLQHHYWTNHLHNERVLFEKAAEEHSQLLIRHRIKK 251
Cdd:pfam14798 162 DDEREELLRYLRAQSQILGWLLIAVIILLAFLATCLSRCFSPVSYLQLKYWKNYLEKEQELFEETAKEHARQLAKRNVKC 241


                  ....*..
gi 124487203  252 VFGFVPG 258
Cdd:pfam14798 242 FFESSQP 248
 
Name Accession Description Interval E-value
Ca_hom_mod pfam14798
Calcium homeostasis modulator; This family of proteins control cytosolic calcium concentration. ...
 14-258 1.17e-80

Calcium homeostasis modulator; This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.


Pssm-ID: 464320  Cd Length: 248  Bit Score: 244.85  E-value: 1.17e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487203   14 RSEPCINSLIAILTVCGQQLFSSYTFSCPCQVGKNFYYGSAFLVVPALILLIAGYALRGQMWtvasEYCCCSCTPPYRRS 93
Cdd:pfam14798  13 HKESLGNGLVALLTAGGERIFSSVVFQCPCSPGYNFLYGLVFLLVPALVLFLLGYLLNTRTW----RLLTGCCRPTGKRS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487203   94 spleRRLACL--MFFDITGRALVAPLTWLTVTLLTGTYYECAASEFASVDQypmFANVTPSKREEMLAGFPCYTSAPSDV 171
Cdd:pfam14798  89 ----KRPACLryVFGSITVRALVAPLTWLAVALLDGEFYECAGSEFVDPAK---FLCKTSSCAAEELAKVPCKKSVLPPV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487203  172 IPIRDEVALLHRYQSQMLGWILVVLATIALLLSKCLARCCSPLTSLQHHYWTNHLHNERVLFEKAAEEHSQLLIRHRIKK 251
Cdd:pfam14798 162 DDEREELLRYLRAQSQILGWLLIAVIILLAFLATCLSRCFSPVSYLQLKYWKNYLEKEQELFEETAKEHARQLAKRNVKC 241


                  ....*..
gi 124487203  252 VFGFVPG 258
Cdd:pfam14798 242 FFESSQP 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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