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Conserved domains on  [gi|124486895|ref|NP_001074743|]
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6-phosphogluconate dehydrogenase, decarboxylating isoform 1 [Mus musculus]

Protein Classification

NADP(+)-dependent, decarboxylating phosphogluconate dehydrogenase( domain architecture ID 11417508)

NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate, as part of the oxidative branch of the pentose phosphate pathway

CATH:  3.40.50.720|1.20.5.320
EC:  1.1.1.44
Gene Ontology:  GO:0004616|GO:0050661|GO:0006098|GO:0046177
PubMed:  35234135|34709178|26479318
SCOP:  3000048

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 2-469 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 865.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895   2 AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKDMVSKLKKPRRVILLVKAGQAV 81
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  82 DDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFvgsgvsggeegARYGPSLMPGGNKEAWPHIKAIFQAIA 161
Cdd:COG0362   81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFigmgvsggeegALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 162 AKVGtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTELDSFLIEITANILK 241
Cdd:COG0362  161 AKVD-GEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 242 YRDT-DGKELLPKIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLKGPKVVQLEGSKKSFL 320
Cdd:COG0362  240 KKDPeTGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAFI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 321 EDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVD 400
Cdd:COG0362  320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124486895 401 NCQDSWRRVISTGVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKPGEFiHTNW 469
Cdd:COG0362  400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFF-HTEW 467
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 2-469 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 865.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895   2 AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKDMVSKLKKPRRVILLVKAGQAV 81
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  82 DDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFvgsgvsggeegARYGPSLMPGGNKEAWPHIKAIFQAIA 161
Cdd:COG0362   81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFigmgvsggeegALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 162 AKVGtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTELDSFLIEITANILK 241
Cdd:COG0362  161 AKVD-GEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 242 YRDT-DGKELLPKIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLKGPKVVQLEGSKKSFL 320
Cdd:COG0362  240 KKDPeTGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAFI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 321 EDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVD 400
Cdd:COG0362  320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124486895 401 NCQDSWRRVISTGVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKPGEFiHTNW 469
Cdd:COG0362  400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFF-HTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
14-470 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 825.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  14 MGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKDMVSKLKKPRRVILLVKAGQAVDDFIEKLVPLLD 93
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEEGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  94 TGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKAIFQAIAAKVGTGEPCCDW 173
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 174 VGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTELDSFLIEITANILKYRD-TDGKELLP 252
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDeETGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 253 KIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLKGPKvVQLEGSKKSFLEDIRKALYASKI 332
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPA-AKFEGDKAEFIEDVRQALYASKI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 333 ISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVDNCQDSWRRVIST 412
Cdd:PRK09287 320 VSYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVAL 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124486895 413 GVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKPGEFiHTNWT 470
Cdd:PRK09287 400 AVQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFF-HTEWS 456
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 5-470 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 802.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895    5 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKDMVSKLKKPRRVILLVKAGQAVDDF 84
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEEAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895   85 IEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKAIFQAIAAKV 164
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  165 GtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTELDSFLIEITANILKYRD 244
Cdd:TIGR00873 161 D-GEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  245 TDGKELLPKIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLKGPKVVQLEGSKKSFLEDIR 324
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGVDKEEFIEDVR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  325 KALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVDNCQD 404
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124486895  405 SWRRVISTGVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKP-GEFIHTNWT 470
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPrGEFFHTNWT 466
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 180-469 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 572.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  180 GHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTELDSFLIEITANILKYRD-TDGKELLPKIRDSA 258
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDpEDGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  259 GQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLKGPKVVQLEGSKKSFLEDIRKALYASKIISYAQG 338
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPPPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  339 FMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVDNCQDSWRRVISTGVQAGI 418
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 124486895  419 PMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKPGeFIHTNW 469
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEG-FFHTEW 290
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 2-469 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 865.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895   2 AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKDMVSKLKKPRRVILLVKAGQAV 81
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  82 DDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFvgsgvsggeegARYGPSLMPGGNKEAWPHIKAIFQAIA 161
Cdd:COG0362   81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFigmgvsggeegALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 162 AKVGtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTELDSFLIEITANILK 241
Cdd:COG0362  161 AKVD-GEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 242 YRDT-DGKELLPKIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLKGPKVVQLEGSKKSFL 320
Cdd:COG0362  240 KKDPeTGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAFI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 321 EDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVD 400
Cdd:COG0362  320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124486895 401 NCQDSWRRVISTGVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKPGEFiHTNW 469
Cdd:COG0362  400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFF-HTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
14-470 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 825.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  14 MGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKDMVSKLKKPRRVILLVKAGQAVDDFIEKLVPLLD 93
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEEGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  94 TGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKAIFQAIAAKVGTGEPCCDW 173
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 174 VGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTELDSFLIEITANILKYRD-TDGKELLP 252
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDeETGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 253 KIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLKGPKvVQLEGSKKSFLEDIRKALYASKI 332
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPA-AKFEGDKAEFIEDVRQALYASKI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 333 ISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVDNCQDSWRRVIST 412
Cdd:PRK09287 320 VSYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVAL 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124486895 413 GVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKPGEFiHTNWT 470
Cdd:PRK09287 400 AVQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFF-HTEWS 456
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 5-470 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 802.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895    5 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKDMVSKLKKPRRVILLVKAGQAVDDF 84
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEEAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895   85 IEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKAIFQAIAAKV 164
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  165 GtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTELDSFLIEITANILKYRD 244
Cdd:TIGR00873 161 D-GEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  245 TDGKELLPKIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLKGPKVVQLEGSKKSFLEDIR 324
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGVDKEEFIEDVR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  325 KALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVDNCQD 404
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124486895  405 SWRRVISTGVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKP-GEFIHTNWT 470
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPrGEFFHTNWT 466
PTZ00142 PTZ00142
6-phosphogluconate dehydrogenase; Provisional
 3-470 0e+00

6-phosphogluconate dehydrogenase; Provisional


Pssm-ID: 240287 [Multi-domain]  Cd Length: 470  Bit Score: 696.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895   3 QADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAK-GTKVVGAQSLKDMVSKLKKPRRVILLVKAGQAV 81
Cdd:PTZ00142   1 MSDIGLIGLAVMGQNLALNIASRGFKISVYNRTYEKTEEFVKKAKEgNTRVKGYHTLEELVNSLKKPRKVILLIKAGEAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  82 DDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKAIFQAIA 161
Cdd:PTZ00142  81 DETIDNLLPLLEKGDIIIDGGNEWYLNTERRIKRCEEKGILYLGMGVSGGEEGARYGPSLMPGGNKEAYDHVKDILEKCS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 162 AKVGTgEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTELDSFLIEITANILK 241
Cdd:PTZ00142 161 AKVGD-SPCVTYVGPGSSGHYVKMVHNGIEYGDMQLISESYKLMKHILGMSNEELSEVFNKWNEGILNSYLIEITAKILA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 242 YRDTDGKE-LLPKIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLKGPKVVQL--EGSKKS 318
Cdd:PTZ00142 240 KKDDLGEEhLVDKILDIAGSKGTGKWTVQEALERGIPVPTMAASVDARNISALKEERTKASSHLAGPNPANKteTEDKKY 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 319 FLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSA 398
Cdd:PTZ00142 320 FIDDLKNALYCSKIISYTQGFFLIKEASKEFGWNLNLGEIARIWRGGCIIRAVFLDRIKNAFKKNPQLDLLFLDPDFNDE 399

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124486895 399 VDNCQDSWRRVISTGVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKPGEFiHTNWT 470
Cdd:PTZ00142 400 LKNKQPSWRKVVSMATKNGIPTPAFSASLAYYQMYRSQNLPANLVQAQRDYFGAHTYKRLDRPGAF-HTNWE 470
PLN02350 PLN02350
phosphogluconate dehydrogenase (decarboxylating)
 1-470 0e+00

phosphogluconate dehydrogenase (decarboxylating)


Pssm-ID: 215200 [Multi-domain]  Cd Length: 493  Bit Score: 583.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895   1 MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFL--ANEAKGTKVVGAQSLKDMVSKLKKPRRVILLVKAG 78
Cdd:PLN02350   4 AALSRIGLAGLAVMGQNLALNIAEKGFPISVYNRTTSKVDETVerAKKEGNLPLYGFKDPEDFVLSIQKPRSVIILVKAG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  79 QAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKAIFQ 158
Cdd:PLN02350  84 APVDQTIKALSEYMEPGDCIIDGGNEWYENTERRIKEAAEKGLLYLGMGVSGGEEGARNGPSLMPGGSFEAYKNIEDILE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 159 AIAAKVGTGePCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTELDSFLIEITAN 238
Cdd:PLN02350 164 KVAAQVDDG-PCVTYIGPGGAGNFVKMVHNGIEYGDMQLISEAYDVLKSVGGLSNEELAEVFAEWNKGELESFLIEITAD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 239 ILKYRD-TDGKELLPKIRDSAGQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLKGPKVVQLEGS-- 315
Cdd:PLN02350 243 IFSVKDdKGDGYLVDKILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDARYLSGLKEERVAAAKVFKEAGLEDILSAds 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 316 ---KKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLD 392
Cdd:PLN02350 323 gvdKKQLIDDVRQALYASKICSYAQGMNLIRAKSVEKGWNLNLGELARIWKGGCIIRAVFLDRIKKAYDRNPDLASLLVD 402

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124486895 393 -DFFKSAVDNcQDSWRRVISTGVQAGIPMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKPGEFiHTNWT 470
Cdd:PLN02350 403 pEFAKEMVER-QAAWRRVVSLAINAGISTPGMSASLAYFDTYRRARLPANLVQAQRDYFGAHTYERVDRPGSF-HTEWT 479
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 180-469 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 572.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  180 GHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMRHEEMAQAFEEWNKTELDSFLIEITANILKYRD-TDGKELLPKIRDSA 258
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDpEDGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  259 GQKGTGKWTAISALEYGMPVTLIGEAVFARCLSSLKEERVQASQKLKGPKVVQLEGSKKSFLEDIRKALYASKIISYAQG 338
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPPPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  339 FMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFERNPELQNLLLDDFFKSAVDNCQDSWRRVISTGVQAGI 418
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 124486895  419 PMPCFTTALSFYDGYRHEMLPANLIQAQRDYFGAHTYELLTKPGeFIHTNW 469
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEG-FFHTEW 290
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
5-297 1.23e-74

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 236.95  E-value: 1.23e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895   5 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDdflanEAKGTKVVGAQSLKDMVSKLKKPRRVILLVKAGQAVDDF 84
Cdd:PRK09599   2 QLGMIGLGRMGGNMARRLLRGGHEVVGYDRNPEAVE-----ALAEEGATGADSLEELVAKLPAPRVVWLMVPAGEITDAT 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  85 IEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKAIFQAIAAKV 164
Cdd:PRK09599  77 IDELAPLLSPGDIVIDGGNSYYKDDIRRAELLAEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALAPRA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 165 GTGepccdWV--GDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKdvlgmrHEE----MAQAFEEWNK-TELDSFLIEITA 237
Cdd:PRK09599 157 EDG-----YLhaGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLE------ASRfdldLAAVAEVWRRgSVIRSWLLDLTA 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 238 NILKyRDTDGKELLPKIRDSagqkGTGKWTAISALEYGMPVTLIGEAVFARcLSSLKEER 297
Cdd:PRK09599 226 DALA-EDPKLDEISGYVEDS----GEGRWTVEEAIDLAVPAPVIAAALFMR-FRSRQEDS 279
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
6-296 4.28e-73

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 233.06  E-value: 4.28e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895   6 IALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFlanEAKGtkVVGAQSLKDMVSKLKKPRRVILLVKAGQAVDDFI 85
Cdd:COG1023    3 IGMIGLGKMGGNMARRLLRHGHEVVGYDRNPEAVAAL---AAEG--ATGADSLEELVAKLPAPRVVWLMVPAGEITDQVI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  86 EKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKAIFQAIAAKVG 165
Cdd:COG1023   78 EELAPLLEPGDIVIDGGNSNYKDDIRRAEELAEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALAPGAE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895 166 TGepcCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKdvlgmrHEE----MAQAFEEWNK-TELDSFLIEITANIL 240
Cdd:COG1023  158 NG---YLHCGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLE------ASEfdldLAEVAEVWRRgSVIRSWLLDLTADAL 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 124486895 241 KyRDTDGKELLPKIRDSagqkGTGKWTAISALEYGMPVTLIGEAVFARcLSSLKEE 296
Cdd:COG1023  229 A-EDPKLEGISGYVEDS----GEGRWTVEEAIELGVPAPVITAALFAR-FRSRQED 278
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 5-175 2.64e-49

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 166.11  E-value: 2.64e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895    5 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGtkvvgAQSLKDMVSKLkkpRRVILLVKAGQAVDDF 84
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVAAGAIA-----AASPAEFVAGL---DVVITMVPAGAAVDAV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895   85 I--EKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGP-SLMPGGNKEAWPHIKAIFQAIA 161
Cdd:pfam03446  73 IfgEGLLPGLKPGDIIIDGSTSSPEDARRRAKELKEKGLHFLDAPVSGGEAGAENGTlSIMVGGDEEAFERVKPILEAMG 152

                         170
                  ....*....|....
gi 124486895  162 AkvgtgepCCDWVG 175
Cdd:pfam03446 153 A-------CVTYIG 159
gnd_rel TIGR00872
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ...
 6-288 5.69e-46

6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273313 [Multi-domain]  Cd Length: 298  Bit Score: 161.94  E-value: 5.69e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895    6 IALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDdflanEAKGTKVVGAQSLKDMVSKLKKPRRVILLVKAGqAVDDFI 85
Cdd:TIGR00872   3 LGLIGLGRMGANIVRRLAKRGHDCVGYDHDQDAVK-----AMKEDRTTGVANLRELSQRLSAPRVVWVMVPHG-IVDAVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895   86 EKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKAIFQAIAAKvg 165
Cdd:TIGR00872  77 EELAPTLEKGDIVIDGGNSYYKDSLRRYKLLKEKGIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADVAPE-- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  166 tgEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDV-LGMRHEEMAqafEEWNK-TELDSFLIEITANILKyR 243
Cdd:TIGR00872 155 --EQGYLYCGPCGSGHFVKMVHNGIEYGMMAAIAEGFEILRNSqFDFDIPEVA---RVWRRgSVIRSWLLDLTAIAFR-E 228

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 124486895  244 DTDGKELLPKIRDSagqkGTGKWTAISALEYGMPVTLIGEAVFAR 288
Cdd:TIGR00872 229 SPDLAEFSGRVSDS----GEGRWTVIAAIDLGVPAPVIATSLQSR 269
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 6-223 7.31e-17

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 80.54  E-value: 7.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895   6 IALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFlanEAKGTKVvgAQSLKDMVSKLkkpRRVILLVKAGQAVDDFI 85
Cdd:COG2084    4 VGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEAL---VAAGARV--AASPAEAAAAA---DVVITMLPDDAAVEEVL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  86 ---EKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGIlfvgsgvsggeegaRY-------GP--------SLMPGGNK 147
Cdd:COG2084   76 lgeDGLLAALRPGAVVVDMSTISPETARELAAAAAARGV--------------RYldapvsgGPagaeagtlTIMVGGDE 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124486895 148 EAWPHIKAIFQAIAAKVgtgepccDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDvLGMRHEEMAQAFEEW 223
Cdd:COG2084  142 AAFERARPVLEAMGKRI-------VHVGDAGAGQAAKLANNLLLAGTMAALAEALALAEK-AGLDPETLLEVLSGG 209
garR PRK11559
tartronate semialdehyde reductase; Provisional
 5-185 2.46e-04

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 43.12  E-value: 2.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895   5 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKgtkvvGAQSLKDMVSKLKKprrVILLVKAGQAVDDF 84
Cdd:PRK11559   4 KVGFIGLGIMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIAAGAE-----TASTAKAVAEQCDV---IITMLPNSPHVKEV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486895  85 I---EKLVPLLDTGDIIIDgGNSEYRDTTRRCRD-LKAKGILFVGSGVSGGEEGARYGP-SLMPGGNKEAWPHIKAIFQA 159
Cdd:PRK11559  76 AlgeNGIIEGAKPGTVVID-MSSIAPLASREIAAaLKAKGIEMLDAPVSGGEPKAIDGTlSVMVGGDKAIFDKYYDLMKA 154

                        170       180
                 ....*....|....*....|....*.
gi 124486895 160 IAAKVgtgepccDWVGDEGAGHFVKM 185
Cdd:PRK11559 155 MAGSV-------VHTGDIGAGNVTKL 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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