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Conserved domains on  [gi|124487161|ref|NP_001074875|]
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leucine-rich repeat protein 1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
164-312 3.46e-32

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 126.20  E-value: 3.46e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 164 LEHLQASYCSLARVDMRMLCLKNLTKLDLSHNCIKKLPATIGDLTHLQELNLNDNQLETFSVPLCTSTlqkSLHSLDLSK 243
Cdd:COG4886  115 LESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLT---NLKELDLSN 191

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124487161 244 NKIKALPVQFCQFRELTNLNLNDNELIHLPFKIGQLTNLRFLSAARNKLRNLPSEFKMLSLEYLDLFGN 312
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNN 260
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
164-312 3.46e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 126.20  E-value: 3.46e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 164 LEHLQASYCSLARVDMRMLCLKNLTKLDLSHNCIKKLPATIGDLTHLQELNLNDNQLETFSVPLCTSTlqkSLHSLDLSK 243
Cdd:COG4886  115 LESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLT---NLKELDLSN 191

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124487161 244 NKIKALPVQFCQFRELTNLNLNDNELIHLPFKIGQLTNLRFLSAARNKLRNLPSEFKMLSLEYLDLFGN 312
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 183-312 5.68e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 5.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 183 CLKNLTKLDLSHNCIKKLpATIGDLTHLQELNLNDNQL---ETFSV-PLCTSTLQKSLHSLDLSKNKIkalpvqfcqfRE 258
Cdd:cd21340   66 NLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLppgEKLTFdPRSLAALSNSLRVLNISGNNI----------DS 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124487161 259 LTNLnlndnelihlpfkiGQLTNLRFLSAARNKLRNL----PSEFKMLSLEYLDLFGN 312
Cdd:cd21340  135 LEPL--------------APLRNLEQLDASNNQISDLeellDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 186-326 4.93e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 4.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 186 NLTKLDLSHNCIK-KLPATIGDLTHLQELNLNDNQLeTFSVPLCTSTLqKSLHSLDLSKNKIKA-LPVQFCQFRELTNLN 263
Cdd:PLN00113 165 SLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQL-VGQIPRELGQM-KSLKWIYLGYNNLSGeIPYEIGGLTSLNHLD 242

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124487161 264 LNDNELI-HLPFKIGQLTNLRFLSAARNKLRNL--PSEFKMLSLEYLDLFGNTF--EKPEVipIIKLQ 326
Cdd:PLN00113 243 LVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSLsgEIPEL--VIQLQ 308
LRR_8 pfam13855
Leucine rich repeat;
184-220 6.91e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 6.91e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 124487161  184 LKNLTKLDLSHNCIKKL-PATIGDLTHLQELNLNDNQL 220
Cdd:pfam13855  24 LSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
164-312 3.46e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 126.20  E-value: 3.46e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 164 LEHLQASYCSLARVDMRMLCLKNLTKLDLSHNCIKKLPATIGDLTHLQELNLNDNQLETFSVPLCTSTlqkSLHSLDLSK 243
Cdd:COG4886  115 LESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLT---NLKELDLSN 191

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124487161 244 NKIKALPVQFCQFRELTNLNLNDNELIHLPFKIGQLTNLRFLSAARNKLRNLPSEFKMLSLEYLDLFGN 312
Cdd:COG4886  192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
164-333 4.40e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.82  E-value: 4.40e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 164 LEHLQASYCSLARVDMRMLCLKNLTKLDLSHNCIKKLPATIGDLTHLQELNLNDNQLETFSVPLCTSTlqkSLHSLDLSK 243
Cdd:COG4886  138 LKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLT---NLEELDLSG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 244 NKIKALPVQFCQFRELTNLNLNDNELIHLPfKIGQLTNLRFLSAARNKLRNLPSEFKMLSLEYLDLFGNTFEKPEVIPII 323
Cdd:COG4886  215 NQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELE 293

                        170
                 ....*....|
gi 124487161 324 KLQVPLTLLE 333
Cdd:COG4886  294 LLLGLNSLLL 303
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
182-312 4.67e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 4.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 182 LCLKNLTKLDLSHNCIKKLPATIGDLTHLQELNLNDNQ-LETFsvplctstlqKSLHSLDLSKNKIKALPVQFCQFRELT 260
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEeLSNL----------TNLESLDLSGNQLTDLPEELANLTNLK 139

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 124487161 261 NLNLNDNELIHLPFKIGQLTNLRFLSAARNKLRNLPSEFKML-SLEYLDLFGN 312
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLtNLKELDLSNN 192
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
164-341 4.65e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 4.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 164 LEHLQASYCSLARVDMRMLCLKNLTKLDLSHNCIKKLPAtIGDLTHLQELNLNDNQLETFSvplcTSTLQKSLHSLDLSK 243
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLP----PLANLTNLKTLDLSN 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 244 NKIKALPVQFCQFRELTNLNLNDNELIHLPFKIGQLTNLRFLSAARNKLRNLPSEFKMLSLEYLDLFGNTFEKPEVIPII 323
Cdd:COG4886  282 NQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361

                        170
                 ....*....|....*...
gi 124487161 324 KLQVPLTLLESCEQAVLF 341
Cdd:COG4886  362 LLTLLLTLGLLGLLEATL 379
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 183-312 5.68e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 5.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 183 CLKNLTKLDLSHNCIKKLpATIGDLTHLQELNLNDNQL---ETFSV-PLCTSTLQKSLHSLDLSKNKIkalpvqfcqfRE 258
Cdd:cd21340   66 NLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLppgEKLTFdPRSLAALSNSLRVLNISGNNI----------DS 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124487161 259 LTNLnlndnelihlpfkiGQLTNLRFLSAARNKLRNL----PSEFKMLSLEYLDLFGN 312
Cdd:cd21340  135 LEPL--------------APLRNLEQLDASNNQISDLeellDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 186-326 4.93e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 4.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 186 NLTKLDLSHNCIK-KLPATIGDLTHLQELNLNDNQLeTFSVPLCTSTLqKSLHSLDLSKNKIKA-LPVQFCQFRELTNLN 263
Cdd:PLN00113 165 SLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQL-VGQIPRELGQM-KSLKWIYLGYNNLSGeIPYEIGGLTSLNHLD 242

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124487161 264 LNDNELI-HLPFKIGQLTNLRFLSAARNKLRNL--PSEFKMLSLEYLDLFGNTF--EKPEVipIIKLQ 326
Cdd:PLN00113 243 LVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSLsgEIPEL--VIQLQ 308
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 185-312 5.86e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 5.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 185 KNLTKLDLSHNCIKK-LPATIGDLTHLQELNLNDNQLeTFSVPLCTSTLQKsLHSLDLSKNKIKA-LPVQFCQFRELTNL 262
Cdd:PLN00113 475 KRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKL-SGEIPDELSSCKK-LVSLDLSHNQLSGqIPASFSEMPVLSQL 552

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 124487161 263 NLNDNELI-HLPFKIGQLTNLRFLSAARNKLR-NLPSEFKMLSLEYLDLFGN 312
Cdd:PLN00113 553 DLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPSTGAFLAINASAVAGN 604
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 186-321 4.89e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.16  E-value: 4.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 186 NLTKLDLSHNCIK-KLPATIGDLTHLQELNLNDNQLETfSVPLCTSTLQkSLHSLDLSKNKIKA-LPVQFCQFRELTNLN 263
Cdd:PLN00113 357 NLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEG-EIPKSLGACR-SLRRVRLQDNSFSGeLPSEFTKLPLVYFLD 434

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 264 LNDNELI-HLPFKIGQLTNLRFLSAARNK-LRNLPSEFKMLSLEYLDLFGNTFEkpEVIP 321
Cdd:PLN00113 435 ISNNNLQgRINSRKWDMPSLQMLSLARNKfFGGLPDSFGSKRLENLDLSRNQFS--GAVP 492
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
186-321 5.73e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 5.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 186 NLTKLDLSHNCIKKLPATIGDLTHLQELNLNDnqleTFSVPlctSTLQKSLHSLDLSKNKIKALPVQFCQfrELTNLNLN 265
Cdd:PRK15370 221 NIKTLYANSNQLTSIPATLPDTIQEMELSINR----ITELP---ERLPSALQSLDLFHNKISCLPENLPE--ELRYLSVY 291

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124487161 266 DNELI----HLPFKIGQL---------------TNLRFLSAARNKLRNLPSEFKMlSLEYLDLFGNTFEK-PEVIP 321
Cdd:PRK15370 292 DNSIRtlpaHLPSGITHLnvqsnsltalpetlpPGLKTLEAGENALTSLPASLPP-ELQVLDVSKNQITVlPETLP 366
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
156-296 1.85e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 1.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 156 LSKNFPyflEHLQasYCSLARVDMRML---CLKNLTKLDLSHNCIKKLPATIGdlTHLQELNLNDNQLEtfSVPlctSTL 232
Cdd:PRK15370 277 LPENLP---EELR--YLSVYDNSIRTLpahLPSGITHLNVQSNSLTALPETLP--PGLKTLEAGENALT--SLP---ASL 344

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124487161 233 QKSLHSLDLSKNKIKALPVQFCQfrELTNLNLNDNELIHLPFKIGqlTNLRFLSAARNKLRNLP 296
Cdd:PRK15370 345 PPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLP 404
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 190-312 1.88e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 1.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 190 LDLSHNCIK-KLPATIGDLTHLQELNLNDNQletFSVPLCTSTLQKSLHSLDLSKNKIK-ALPVQFCQFRELTNLNLNDN 267
Cdd:PLN00113 433 LDISNNNLQgRINSRKWDMPSLQMLSLARNK---FFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSEN 509

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 124487161 268 ELI-HLPFKIGQLTNLRFLSAARNKLR-NLPSEF-KMLSLEYLDLFGN 312
Cdd:PLN00113 510 KLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFsEMPVLSQLDLSQN 557
PLN03150 PLN03150
hypothetical protein; Provisional
 200-269 4.15e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.04  E-value: 4.15e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124487161 200 LPATIGDLTHLQELNLNDNQLETfSVPLCTSTLqKSLHSLDLSKNKIK-ALPVQFCQFRELTNLNLNDNEL 269
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRG-NIPPSLGSI-TSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 187-309 5.41e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 5.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 187 LTKLDLS-HNCIKKLPATIGDLTHLQELNLNDNQLeTFSVPLCTSTLQKS----------------------LHSLDLSK 243
Cdd:PLN00113  71 VVSIDLSgKNISGKISSAIFRLPYIQTINLSNNQL-SGPIPDDIFTTSSSlrylnlsnnnftgsiprgsipnLETLDLSN 149

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 244 NKIKA-LPVQFCQFRELTNLNLNDNELI-HLPFKIGQLTNLRFLSAARNKLR-NLPSEF-KMLSLEYLDL 309
Cdd:PLN00113 150 NMLSGeIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELgQMKSLKWIYL 219
LRR_8 pfam13855
Leucine rich repeat;
184-220 6.91e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 6.91e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 124487161  184 LKNLTKLDLSHNCIKKL-PATIGDLTHLQELNLNDNQL 220
Cdd:pfam13855  24 LSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 184-269 1.00e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 184 LKNLTKLDLSHNCI-----KKLPATIGDLTHLQELNLNDNQLEtfSVPLCT-----STLQKSLHSLDLSKNKIKALPVQ- 252
Cdd:cd00116  192 NCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLT--DAGAAAlasalLSPNISLLTLSLSCNDITDDGAKd 269

                         90       100
                 ....*....|....*....|.
gi 124487161 253 FCQ----FRELTNLNLNDNEL 269
Cdd:cd00116  270 LAEvlaeKESLLELDLRGNKF 290
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 162-314 1.73e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.58  E-value: 1.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 162 YFLEHLQASYCSLARVDMRMLC--LK----NLTKLDLSHN-----CIKKLPATIGDLTHLQELNLNDNQLETFSVP-LCT 229
Cdd:cd00116  108 SSLQELKLNNNGLGDRGLRLLAkgLKdlppALEKLVLGRNrlegaSCEALAKALRANRDLKELNLANNGIGDAGIRaLAE 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 230 S-TLQKSLHSLDLSKNKI-----KALPVQFCQFRELTNLNLNDNEL-------IHLPFKIGqLTNLRFLSAARNKLRNLP 296
Cdd:cd00116  188 GlKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLtdagaaaLASALLSP-NISLLTLSLSCNDITDDG 266

                        170       180
                 ....*....|....*....|....
gi 124487161 297 SE------FKMLSLEYLDLFGNTF 314
Cdd:cd00116  267 AKdlaevlAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
186-246 2.73e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.73e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124487161  186 NLTKLDLSHNCIKKL-PATIGDLTHLQELNLNDNQLETFS----VPLctstlqKSLHSLDLSKNKI 246
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSpgafSGL------PSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 185-224 3.68e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 3.68e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 124487161  185 KNLTKLDLSHNCIKKLPAtIGDLTHLQELNLNDN-QLETFS 224
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNnKITDLS 40
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
187-312 1.97e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 43.61  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 187 LTKLDLSHNCIKKLPATIGDL-----------------THLQELNLNDNQLEtfSVPLCTSTLQK--------------- 234
Cdd:PRK15387 304 LQELSVSDNQLASLPALPSELcklwaynnqltslptlpSGLQELSVSDNQLA--SLPTLPSELYKlwaynnrltslpalp 381

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 235 -SLHSLDLSKNKIKALPVQFCQFRELTnlnLNDNELIHLPFKIGQLTNlrfLSAARNKLRNLPSEFKMLSLE-YLDLFGN 312
Cdd:PRK15387 382 sGLKELIVSGNRLTSLPVLPSELKELM---VSGNRLTSLPMLPSGLLS---LSVYRNQLTRLPESLIHLSSEtTVNLEGN 455
PLN03150 PLN03150
hypothetical protein; Provisional
 187-220 3.69e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 3.69e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 124487161 187 LTKLDLSHNCIK-KLPATIGDLTHLQELNLNDNQL 220
Cdd:PLN03150 468 LEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 184-314 8.74e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 8.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 184 LKNLTKLDL-SHNCIKKLPATIGDLTHLQELNLNDNQLeTFSVPLCTSTlQKSLHSLDLSKNKIKA-LPVQFCQFRELTN 261
Cdd:PLN00113 307 LQNLEILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKF-SGEIPKNLGK-HNNLTVLDLSTNNLTGeIPEGLCSSGNLFK 384

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 124487161 262 LNLNDNELI-HLPFKIGQLTNLRFLSAARNKLR-NLPSEFKMLSLEY-LDLFGNTF 314
Cdd:PLN00113 385 LILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYfLDISNNNL 440
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 179-308 1.64e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.01  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161  179 MRMLClKNLTKLDLSHN-CIKKLPATIGDLTHLQELNL-NDNQLETfsvpLCTSTLQKSLHSLDLSK-NKIKALPVQFCQ 255
Cdd:PLN03210  773 MTMLS-PSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIeNCINLET----LPTGINLESLESLDLSGcSRLRTFPDISTN 847

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 124487161  256 freLTNLNLNDNELIHLPFKIGQLTNLRFLS--AARNKLRNLPSEFKMLSLEYLD 308
Cdd:PLN03210  848 ---ISDLNLSRTGIEEVPWWIEKFSNLSFLDmnGCNNLQRVSLNISKLKHLETVD 899
LRR_8 pfam13855
Leucine rich repeat;
235-292 1.99e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124487161  235 SLHSLDLSKNKIKALPVQFcqFRELTNL---NLNDNELIHLPFK-IGQLTNLRFLSAARNKL 292
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGA--FKGLSNLkvlDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 185-320 2.60e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 2.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 185 KNLTKLDLSHNCIKKLPAtIGDLTHLQELNLNDNQLETFSVPLCTSTLQKslhsLDLSKNKIKALpvqfCQFRELTNL-- 262
Cdd:cd21340   24 KNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIENLENLVNLKK----LYLGGNRISVV----EGLENLTNLee 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124487161 263 ------NL-NDNELIHLPFKI-GQLTNLRFLSAARNKLRNLpSEFKML-SLEYLDLFGNTFEKPEVI 320
Cdd:cd21340   95 lhienqRLpPGEKLTFDPRSLaALSNSLRVLNISGNNIDSL-EPLAPLrNLEQLDASNNQISDLEEL 160
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 185-269 4.53e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.00  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487161 185 KNLTKLDLSHNCI-----KKLPATIGDLTHLQELNLNDNQLETFSVPLCTSTLQ--KSLHSLDLSKNKIKALPVQFC--- 254
Cdd:COG5238  320 KTLHTLNLAYNGIgaqgaIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEgnTTLRELNLGKNNIGKQGAEALida 399

                         90
                 ....*....|....*.
gi 124487161 255 -QFRELTNLNLNDNEL 269
Cdd:COG5238  400 lQTNRLHTLILDGNLI 415
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 280-313 7.87e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 7.87e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 124487161  280 TNLRFLSAARNKLRNLPSEFKMLSLEYLDLFGNT 313
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNN 34
LRR_8 pfam13855
Leucine rich repeat;
257-312 8.89e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 8.89e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124487161  257 RELTNLNLNDNELIHLP---FKigQLTNLRFLSAARNKLRNLPSE--FKMLSLEYLDLFGN 312
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgaFK--GLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGN 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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