BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    1 MELPNYSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLLDNTDTISIDASVVSPEEFALLLEMMYT 80
Cdd:cd18225     1 MELPNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASVVSPEEFALLLEMVYT 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 139394579   81 GKLPVGKHNFSKIISLADSLQMFDVAVSCKNLLTSL 116
Cdd:cd18225    81 GKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTSL 116

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579  917 GDKPYVCR--DCGKGFRQANGLSIHlhtfhniedpydckkcrmsfptlqdhRKHIHEVHSKEYHPCPTCGKIFSAPSmle 994
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH--------------------------MLHGHQNQKLHENPSPEKMNIFSAKD--- 396

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 139394579  995 rhvvthvggKPFSCGICNKAYQQLSGLWYHnRTHHPD 1031
Cdd:COG5189   397 ---------KPYRCEVCDKRYKNLNGLKYH-RKHSHD 423

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    1 MELPNYSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLLDNTDTISIDASVVSPEEFALLLEMMYT 80
Cdd:cd18225     1 MELPNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASVVSPEEFALLLEMVYT 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 139394579   81 GKLPVGKHNFSKIISLADSLQMFDVAVSCKNLLTSL 116
Cdd:cd18225    81 GKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTSL 116

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579     25 DCTISIGTIYFRAHKLVLAAASLLFKTLL------DNTDTISIDAsvVSPEEFALLLEMMYTGKLPVGKHNFSKIISLAD 98
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFssdfkeSDKSEIYLDD--VSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                            90
                    ....*....|....*
gi 139394579     99 SLQMFDVAVSCKNLL 113
Cdd:smart00225   79 YLQIPGLVELCEEFL 93

FOG: Zn-finger [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579  794 EPDAPKKKKKRLPVTCDLCGREFAHASGMQYHKLTEHFDE---KPFSCEE--CGAKFAANSTLKNHLRLHTGDRPFMCK- 867
Cdd:COG5048   277 ESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKl 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579  868 -HCLMTFTQASALAYHT----KKKHSEGKMYACQY--CDAVFAQSIELSRHVRTHTGDKPYVCRD--CGKGFRQANGLSI 938
Cdd:COG5048   357 lNSSSKFSPLLNNEPPQslqqYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIP 436

                         170       180       190
                  ....*....|....*....|....*....|..
gi 139394579  939 HLHTfHNIEDPYDCKKCRMSFPTLQDHRKHIH 970
Cdd:COG5048   437 HKKI-HTNHAPLLCSILKSFRRDLDLSNHGKD 467

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579  917 GDKPYVCR--DCGKGFRQANGLSIHlhtfhniedpydckkcrmsfptlqdhRKHIHEVHSKEYHPCPTCGKIFSAPSmle 994
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH--------------------------MLHGHQNQKLHENPSPEKMNIFSAKD--- 396

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 139394579  995 rhvvthvggKPFSCGICNKAYQQLSGLWYHnRTHHPD 1031
Cdd:COG5189   397 ---------KPYRCEVCDKRYKNLNGLKYH-RKHSHD 423

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    1 MELPNYSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLLDNTDTISIDASVVSPEEFALLLEMMYT 80
Cdd:cd18225     1 MELPNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASVVSPEEFALLLEMVYT 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 139394579   81 GKLPVGKHNFSKIISLADSLQMFDVAVSCKNLLTSL 116
Cdd:cd18225    81 GKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTSL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    1 MELPNYSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAAS----LLFKTLLDNTDTISIDASVVSPEEFALLLE 76
Cdd:cd18324     1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSmyfhLFYKDQLDKRDIVHLNSDIVTAPAFALLLE 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 139394579   77 MMYTGKLPVGKHNFSKIISLADSLQMFDVAVSCKNLL 113
Cdd:cd18324    81 FMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    1 MELPNYSRQLLQQLYTLcKEQQF-CDCTISIGTIYFRAHKLVLAAAS----LLFKTLLDNTDTISIDASVVSPEEFALLL 75
Cdd:cd18194     1 MEFPEHSRQLLQCLREQ-RSQGFlCDCTVLVGSAQFPAHRAVLASCSmyfhLFYRDRLDKRDLVRLNSDIVTAPAFGLLL 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 139394579   76 EMMYTGKLPVGKHNFSKIISLADSLQMFDVAVSCKNLL 113
Cdd:cd18194    80 DFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    3 LPNYSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLLDNTDTISIDASVVSPEEFALLLEMMYTGK 82
Cdd:cd18333     1 VPSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLINLDHEMVSPGIFRLILDYIYTGR 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 139394579   83 L----PVGKHNFSKIISLADSLQMFDVAVSCKNLL 113
Cdd:cd18333    81 LsegdPGSEQNLGAVLAAASYLQIPDLVALCKKKL 115

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    19 KEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLLDNTDTIS----IDASVVSPEEFALLLEMMYTGKLPVGKhNFSKII 94
Cdd:pfam00651    6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESsvseITLDDVSPEDFEALLEFMYTGKLISEE-NVDDLL 84

                           90
                   ....*....|....*....
gi 139394579    95 SLADSLQMFDVAVSCKNLL 113
Cdd:pfam00651   85 AAADKLQIPSLVDKCEEFL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579   10 LLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLL-----DNTDTISIDASVVSPEEFALLLEMMYTGKLP 84
Cdd:cd18329     8 LLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLsqnakETGQPTVATFDVFSPDTFTIILDFVYSGKLS 87

                          90       100
                  ....*....|....*....|....*....
gi 139394579   85 VGKHNFSKIISLADSLQMFDVAVSCKNLL 113
Cdd:cd18329    88 LTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    6 YSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLL-----DNTDTISIDASVVSPEEFALLLEMMYT 80
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLshyiqDTGRPSTASFDVFSSDAFSIILDFVYS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 139394579   81 GKLPVGKHNFSKIISLADSLQMFDVAVSCK 110
Cdd:cd18199    81 GKLSLTSQNVIEVMSAASYLQMTDVINVCK 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    4 PNYSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLLDNTDTISIDASVVSPEEFALLLEMMYTGKL 83
Cdd:cd18216     1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNLIHLDQDMVSPTVFQQILDFIYTGKL 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 139394579   84 PVG---KHNFSKIISLADSLQMFDVAVSCKNLL 113
Cdd:cd18216    81 LDSlfeEPNLSEVLAAANYLQLPDLAALCRSKL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    5 NYSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLL--------DNTDTISIDasVVSPEEFALLLE 76
Cdd:cd18201     3 SYCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYcftnkescDQTTVTHLD--VVAVQGFSVILD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 139394579   77 MMYTGKLPVGKHNFSKIISLADSLQMFDVAVSCKNLLTSLVN 118
Cdd:cd18201    81 FMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    1 MELPNYSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLF--KTLLDNTDTISIdASVVSPEEFALLLEMM 78
Cdd:cd18227     3 VEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFcdQVLLKNSRRIVL-PDVMNPRVFENILLSC 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 139394579   79 YTGKLPVGKHNFSKIISLADSLQMFDVAVSCKNLL 113
Cdd:cd18227    82 YTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579   10 LLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLLDN------TDTISIDASVVSPEEFALLLEMMYTGKL 83
Cdd:cd18245     1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYnppkddGSTYKIELEGISVEVMEEILDYIYTGQI 80

                          90       100
                  ....*....|....*....|....*.
gi 139394579   84 PVGKHNFSKIISLADSLQMFDVAVSC 109
Cdd:cd18245    81 KLSEDNIQDIVQAADLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    6 YSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLLdnTDTISIDASVVSPEE-------------FA 72
Cdd:cd18228     2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKL--VGQASPRLVLVSPAGkcvldlhhvtvtgFA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 139394579   73 LLLEMMYTGKLPVGKHNFSKIISLADSLQMFDVAVSCKNLLTS 115
Cdd:cd18228    80 PLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKS 122

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579   23 FCDCTISIGTIYFRAHKLVLAAASLLFKTLLDNTDT-----ISIDAsvVSPEEFALLLEMMYTGKLPVGKHNFSKIISLA 97
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPdehpvIILPD--VPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78

                  ....
gi 139394579   98 DSLQ 101
Cdd:cd18315    79 ELLQ 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    7 SRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLLDN----TDTISIDASVVSPEEFALLLEMMYTGK 82
Cdd:cd18240     1 SAMACNVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNgwneTEKKVYKIPGVSPEMMELIIEYAYTRT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 139394579   83 LPVGKHNFSKIISLADSLQMFDVAVSCKNLLTS---LVNC 119
Cdd:cd18240    81 VPITAENVEELLPAADQFNIMGIVKACCDFLEDqlcPENC 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    3 LPNYSRQLLQQLYTLCKEQQFCD-CTISIGTIyFRAHKLVLAAASLLFKTLLDNTDTISIDASV-----VSPEEFALLLE 76
Cdd:cd18230     1 ITSHYRHLLRELNEQRQHGILCDvCIIVEGKI-FKAHKNVLLGSSRYFKTLYCQVQKTSDQATVthldiVTAQGFKAIID 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 139394579   77 MMYTGKLPVGKHNFSKIISLADSLQMFDVAVSCKNLLTSLVNCSVQ 122
Cdd:cd18230    80 FMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDISIK 125

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579   12 QQLYTLCKEQQFCDCTISI-GTIYFRAHKLVLAAASLLFKTLLDNTDTISIDASVvSPEEFALLLEMMYTGKLPVGKHNF 90
Cdd:cd18299     1 EDLRNLLHSPSCADVVFILqGGVRIFAHRIVLAAASSVFADLFLMMTVVTLDSDI-TPEAFRRVLEFLYTGVLDENEDDL 79

                          90       100
                  ....*....|....*....|....
gi 139394579   91 SKIISLADSLQMFDVAVSCKNLLT 114
Cdd:cd18299    80 KELKDAAELLELFDLVMMCTNVLN 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    4 PNYSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLF--KTLLDNTDTISIdASVVSPEEFALLLEMMYTG 81
Cdd:cd18210     2 PEITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFhdQVLLKNMSSISL-PGVMDPGAFESVLASAYTG 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 139394579   82 KLPVGKHNFSKIISLADSLQMFDVAVSCKNLL 113
Cdd:cd18210    81 KLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579   25 DCTISIGTIYFRAHKLVLAAASLLFKTLLD-----NTDTISIDASVvSPEEFALLLEMMYTGKLPVGKHNFSKIISLADS 99
Cdd:cd18331    26 DVVIVVSREQFRAHKTVLMACSGLFYSIFTdqlkcNLSVINLDPEI-NPEGFNILLDFMYTSRLNLREGNIMAVMATAMY 104

                          90
                  ....*....|....
gi 139394579  100 LQMFDVAVSCKNLL 113
Cdd:cd18331   105 LQMEHVVDTCRKFI 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    4 PNYSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLLDNTDTISIDASV----VSPEEFALLLEMMY 79
Cdd:cd18250     2 PAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVvlhgVSAEILGLLLDFSY 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 139394579   80 TGKLPVGKHNFSKIISLADSLQMFDVAVSC 109
Cdd:cd18250    82 TGRVTVTQDNVEALLRAADLFQFPSVKEAC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    7 SRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLLDNTDTISIDASVVSPEE-------FALLLEMMY 79
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEdpecaavFEKFLRYLY 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 139394579   80 TGKLPVGKHNFSKIISLADSLQMFDVAVSCKN 111
Cdd:cd18292    81 TGQISVNLETALPLLMLADKYNVTDLKQLCVD 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    6 YSRQLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTL----LDNTDTISIDASVVSPEEFALLLEMMYTG 81
Cdd:cd18257     1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMftgnLSEKENSEVEFQCIDETALQAIVEYAYTG 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 139394579   82 KLPVGKHNFSKIISLADSLQMFDVAVSCKNLLTS 115
Cdd:cd18257    81 TVFISQATVESLLPAANLLQIKLVLKECCDFLES 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579   23 FCDCTISIGTIYFRAHKLVLAAASLLFKTLLDNTD-------TISIDASVVSPEEFALLLEMMYTGKLPVGKHNFSKIIS 95
Cdd:cd18307     1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDmkatdelSITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLK 80

                          90
                  ....*....|....*.
gi 139394579   96 LADSLQMFDVAVSCKN 111
Cdd:cd18307    81 GAKYFNIPRLKDHCVD 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139394579    9 QLLQQLYTLCKEQQFCDCTISIGTIYFRAHKLVLAAASLLFKTLLDNtDTISIDASVVSPEEFALLLEMMYTGKLPVGKH 88
Cdd:cd18303     4 RLLKTVASLFDKELYSDITIKLADKSIPAHKFVLAARSEKWSNENLA-STNELDLSDISYEVVLALLRWLYTDELDLTLD 82