NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|146134512|ref|NP_001078878|]
View 

metalloreductase STEAP3 isoform b [Mus musculus]

Protein Classification

COG2085 and Ferric_reduct domain-containing protein( domain architecture ID 11946522)

COG2085 and Ferric_reduct domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
31-204 5.75e-48

Predicted dinucleotide-binding enzyme [General function prediction only];


:

Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 164.19  E-value: 5.75e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512  31 VGILGSGDFARSLATRLVGSGFSVVVGSRNPKR----TAGLFPSLAQVTFqEEAVSSPEVIFVAVFREHYSSLC-SLADQ 105
Cdd:COG2085    1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKaaalAAELGPGARAGTN-AEAAAAADVVVLAVPYEAVPDVLeSLGDA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512 106 LAGKILVDVSNPTEKE-----HLQHRQSNAEYLASLFPACTVVKAFNVISAWALQAGPR--DGNRQVLICSDQPEAKRTI 178
Cdd:COG2085   80 LAGKIVIDATNPLPERdgfilDPPGGGSAAELVAALLPGARVVKAFNTIGAAVLADPARpaGGRRDVFVAGDDAEAKAVV 159

                        170       180
                 ....*....|....*....|....*.
gi 146134512 179 SEMARAMGFTPLDMGSLASAREVEAI 204
Cdd:COG2085  160 AALIEDLGFDPVDAGPLANARRLEPL 185
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 262-405 1.72e-08

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


:

Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 52.66  E-value: 1.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512  262 VAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWldhwlqhRKQIGLLSFFFAMLHALYSFCLPLRRShrydlvnlavkqv 341
Cdd:pfam01794   4 LALALLPLLLLLALRNNPLEWLTGLSYDRLLLF-------HRWLGRLAFLLALLHVILYLIYWLRFS------------- 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146134512  342 lanksrLWAEEEVWRMEIYLSLGVLALGMLSLLAVTSLPSIANsLNWKEFSFVQSTLGFVALIL 405
Cdd:pfam01794  64 ------LEGILDLLLKRPYNILGIIALVLLVLLAITSLPPFRR-LSYELFLYLHILLAVAFLLL 120
 
Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
31-204 5.75e-48

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 164.19  E-value: 5.75e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512  31 VGILGSGDFARSLATRLVGSGFSVVVGSRNPKR----TAGLFPSLAQVTFqEEAVSSPEVIFVAVFREHYSSLC-SLADQ 105
Cdd:COG2085    1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKaaalAAELGPGARAGTN-AEAAAAADVVVLAVPYEAVPDVLeSLGDA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512 106 LAGKILVDVSNPTEKE-----HLQHRQSNAEYLASLFPACTVVKAFNVISAWALQAGPR--DGNRQVLICSDQPEAKRTI 178
Cdd:COG2085   80 LAGKIVIDATNPLPERdgfilDPPGGGSAAELVAALLPGARVVKAFNTIGAAVLADPARpaGGRRDVFVAGDDAEAKAVV 159

                        170       180
                 ....*....|....*....|....*.
gi 146134512 179 SEMARAMGFTPLDMGSLASAREVEAI 204
Cdd:COG2085  160 AALIEDLGFDPVDAGPLANARRLEPL 185
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
32-117 6.31e-22

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 89.98  E-value: 6.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512   32 GILGSGDFARSLATRLVGSGFS--VVVGSRNPKRTAGLFPSL---AQVTFQEEAVSSPEVIFVAVFREHYSSLCS-LADQ 105
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGPHevVVANSRNPEKAEELAEEYgvgATAVDNEEAAEEADVVFLAVKPEDAPDVLSeLSDL 80

                          90
                  ....*....|..
gi 146134512  106 LAGKILVDVSNP 117
Cdd:pfam03807  81 LKGKIVISIAAG 92
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 262-405 1.72e-08

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 52.66  E-value: 1.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512  262 VAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWldhwlqhRKQIGLLSFFFAMLHALYSFCLPLRRShrydlvnlavkqv 341
Cdd:pfam01794   4 LALALLPLLLLLALRNNPLEWLTGLSYDRLLLF-------HRWLGRLAFLLALLHVILYLIYWLRFS------------- 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146134512  342 lanksrLWAEEEVWRMEIYLSLGVLALGMLSLLAVTSLPSIANsLNWKEFSFVQSTLGFVALIL 405
Cdd:pfam01794  64 ------LEGILDLLLKRPYNILGIIALVLLVLLAITSLPPFRR-LSYELFLYLHILLAVAFLLL 120
PLN02688 PLN02688
pyrroline-5-carboxylate reductase
 30-91 2.66e-03

pyrroline-5-carboxylate reductase


Pssm-ID: 178291 [Multi-domain]  Cd Length: 266  Bit Score: 39.55  E-value: 2.66e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 146134512  30 KVGILGSGDFARSLATRLVGSGF-----SVVVGSRNPKRTAgLFPSLAQVTFQ--EEAVSSPEVIFVAV 91
Cdd:PLN02688   2 RVGFIGAGKMAEAIARGLVASGVvppsrISTADDSNPARRD-VFQSLGVKTAAsnTEVVKSSDVIILAV 69
MsrQ COG2717
Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide ...
 298-389 4.38e-03

Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases [Energy production and conversion];


Pssm-ID: 442030  Cd Length: 200  Bit Score: 38.24  E-value: 4.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512 298 WLQHRKQIGLLSFFFAMLHALYSFCLplrrSHRYDLvnlavkqvlankSRLWAeeEVWRMeIYLSLGVLALGMLSLLAVT 377
Cdd:COG2717   70 LLRLRRMLGLWAFFYALLHLLAYLWL----DLGFDL------------ALIWA--DIVKR-PYITVGFAAFLLLLPLALT 130

                         90
                 ....*....|....
gi 146134512 378 SLPSIANSL--NWK 389
Cdd:COG2717  131 STNAAIRRLgrRWK 144
 
Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
31-204 5.75e-48

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 164.19  E-value: 5.75e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512  31 VGILGSGDFARSLATRLVGSGFSVVVGSRNPKR----TAGLFPSLAQVTFqEEAVSSPEVIFVAVFREHYSSLC-SLADQ 105
Cdd:COG2085    1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKaaalAAELGPGARAGTN-AEAAAAADVVVLAVPYEAVPDVLeSLGDA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512 106 LAGKILVDVSNPTEKE-----HLQHRQSNAEYLASLFPACTVVKAFNVISAWALQAGPR--DGNRQVLICSDQPEAKRTI 178
Cdd:COG2085   80 LAGKIVIDATNPLPERdgfilDPPGGGSAAELVAALLPGARVVKAFNTIGAAVLADPARpaGGRRDVFVAGDDAEAKAVV 159

                        170       180
                 ....*....|....*....|....*.
gi 146134512 179 SEMARAMGFTPLDMGSLASAREVEAI 204
Cdd:COG2085  160 AALIEDLGFDPVDAGPLANARRLEPL 185
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
32-117 6.31e-22

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 89.98  E-value: 6.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512   32 GILGSGDFARSLATRLVGSGFS--VVVGSRNPKRTAGLFPSL---AQVTFQEEAVSSPEVIFVAVFREHYSSLCS-LADQ 105
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGPHevVVANSRNPEKAEELAEEYgvgATAVDNEEAAEEADVVFLAVKPEDAPDVLSeLSDL 80

                          90
                  ....*....|..
gi 146134512  106 LAGKILVDVSNP 117
Cdd:pfam03807  81 LKGKIVISIAAG 92
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 262-405 1.72e-08

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 52.66  E-value: 1.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512  262 VAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWldhwlqhRKQIGLLSFFFAMLHALYSFCLPLRRShrydlvnlavkqv 341
Cdd:pfam01794   4 LALALLPLLLLLALRNNPLEWLTGLSYDRLLLF-------HRWLGRLAFLLALLHVILYLIYWLRFS------------- 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146134512  342 lanksrLWAEEEVWRMEIYLSLGVLALGMLSLLAVTSLPSIANsLNWKEFSFVQSTLGFVALIL 405
Cdd:pfam01794  64 ------LEGILDLLLKRPYNILGIIALVLLVLLAITSLPPFRR-LSYELFLYLHILLAVAFLLL 120
COG5495 COG5495
Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains ...
 29-190 8.71e-05

Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains [General function prediction only];


Pssm-ID: 444246 [Multi-domain]  Cd Length: 286  Bit Score: 44.42  E-value: 8.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512  29 PKVGILGSGDFARSLATRLVGSGFSVV-VGSRNP---KRTAGLFPSLAQVTFqEEAVSSPEVIFVAVfreHYSSLCSLAD 104
Cdd:COG5495    4 MKIGIIGAGRVGTALAAALRAAGHEVVgVYSRSPasaERAAALLGAVPALDL-EELAAEADLVLLAV---PDDAIAEVAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512 105 QLA-------GKILVDVSNPTEKEHLQHRQSNAEYLASLFPACTVVKAFNVISAWAlqagprdgnrQVLICSD-QPEAKR 176
Cdd:COG5495   80 GLAaagalrpGQLVVHTSGALGSDVLAPAARAGALTGSFHPLQTFSGPREDLERLA----------GIPFAIEgDEEALP 149

                        170
                 ....*....|....
gi 146134512 177 TISEMARAMGFTPL 190
Cdd:COG5495  150 VLEALAEALGGEPF 163
PLN02688 PLN02688
pyrroline-5-carboxylate reductase
 30-91 2.66e-03

pyrroline-5-carboxylate reductase


Pssm-ID: 178291 [Multi-domain]  Cd Length: 266  Bit Score: 39.55  E-value: 2.66e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 146134512  30 KVGILGSGDFARSLATRLVGSGF-----SVVVGSRNPKRTAgLFPSLAQVTFQ--EEAVSSPEVIFVAV 91
Cdd:PLN02688   2 RVGFIGAGKMAEAIARGLVASGVvppsrISTADDSNPARRD-VFQSLGVKTAAsnTEVVKSSDVIILAV 69
MsrQ COG2717
Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide ...
 298-389 4.38e-03

Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases [Energy production and conversion];


Pssm-ID: 442030  Cd Length: 200  Bit Score: 38.24  E-value: 4.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134512 298 WLQHRKQIGLLSFFFAMLHALYSFCLplrrSHRYDLvnlavkqvlankSRLWAeeEVWRMeIYLSLGVLALGMLSLLAVT 377
Cdd:COG2717   70 LLRLRRMLGLWAFFYALLHLLAYLWL----DLGFDL------------ALIWA--DIVKR-PYITVGFAAFLLLLPLALT 130

                         90
                 ....*....|....
gi 146134512 378 SLPSIANSL--NWK 389
Cdd:COG2717  131 STNAAIRRLgrRWK 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH