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Conserved domains on  [gi|153791870|ref|NP_001093164|]
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zinc finger protein 578 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 2.05e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 2.05e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 153791870   24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
257-582 1.79e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 257 KQYKFDICGKVFNEKRYLARHRRCHTSEKPYKCN--ECGKSFSYKSSLTCHRRCHTGEKPYKCN-ECGKSFSYKSSLTCH 333
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 334 HRCHTGEKPYKCNECGKSFSYKSSLRCHRRLHTGIKPYKCNECGKMFGQ----NSTLVIHKAIHTGEKPYKCNecgkafn 409
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 410 qqsHLSRHHRLHTGEKPYKCNDCGKAFIHQSSLARHHRLHTGEKSYKCEECDRVFSQKSNLERH-KIIHTGEKPYKCNEC 488
Cdd:COG5048  185 ---SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 489 HKTFSH-RSSLPCHRRLHSGE-----KPYKCNECGKTFNVQSHLSRH--HRLHTGE--KPYKCKV--CDKAFMCHSYLAN 556
Cdd:COG5048  262 RSSLPTaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                        330       340
                 ....*....|....*....|....*...
gi 153791870 557 HTRIHSGEKPYKC--NECGKAHNHLIDS 582
Cdd:COG5048  342 HILLHTSISPAKEklLNSSSKFSPLLNN 369
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 2.05e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 2.05e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 153791870   24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB smart00349
krueppel associated box;
24-71 2.21e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.48  E-value: 2.21e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 153791870    24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNLEAVD--ISSKRMM 71
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGfqVPKPDLI 50
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 24-60 3.53e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.50  E-value: 3.53e-15
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 153791870  24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
257-582 1.79e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 257 KQYKFDICGKVFNEKRYLARHRRCHTSEKPYKCN--ECGKSFSYKSSLTCHRRCHTGEKPYKCN-ECGKSFSYKSSLTCH 333
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 334 HRCHTGEKPYKCNECGKSFSYKSSLRCHRRLHTGIKPYKCNECGKMFGQ----NSTLVIHKAIHTGEKPYKCNecgkafn 409
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 410 qqsHLSRHHRLHTGEKPYKCNDCGKAFIHQSSLARHHRLHTGEKSYKCEECDRVFSQKSNLERH-KIIHTGEKPYKCNEC 488
Cdd:COG5048  185 ---SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 489 HKTFSH-RSSLPCHRRLHSGE-----KPYKCNECGKTFNVQSHLSRH--HRLHTGE--KPYKCKV--CDKAFMCHSYLAN 556
Cdd:COG5048  262 RSSLPTaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                        330       340
                 ....*....|....*....|....*...
gi 153791870 557 HTRIHSGEKPYKC--NECGKAHNHLIDS 582
Cdd:COG5048  342 HILLHTSISPAKEklLNSSSKFSPLLNN 369
zf-H2C2_2 pfam13465
Zinc-finger double domain;
469-494 2.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.44e-04
                          10        20
                  ....*....|....*....|....*.
gi 153791870  469 NLERHKIIHTGEKPYKCNECHKTFSH 494
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 2.05e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 2.05e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 153791870   24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB smart00349
krueppel associated box;
24-71 2.21e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.48  E-value: 2.21e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 153791870    24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNLEAVD--ISSKRMM 71
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGfqVPKPDLI 50
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 24-60 3.53e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.50  E-value: 3.53e-15
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 153791870  24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
257-582 1.79e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 257 KQYKFDICGKVFNEKRYLARHRRCHTSEKPYKCN--ECGKSFSYKSSLTCHRRCHTGEKPYKCN-ECGKSFSYKSSLTCH 333
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 334 HRCHTGEKPYKCNECGKSFSYKSSLRCHRRLHTGIKPYKCNECGKMFGQ----NSTLVIHKAIHTGEKPYKCNecgkafn 409
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 410 qqsHLSRHHRLHTGEKPYKCNDCGKAFIHQSSLARHHRLHTGEKSYKCEECDRVFSQKSNLERH-KIIHTGEKPYKCNEC 488
Cdd:COG5048  185 ---SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 489 HKTFSH-RSSLPCHRRLHSGE-----KPYKCNECGKTFNVQSHLSRH--HRLHTGE--KPYKCKV--CDKAFMCHSYLAN 556
Cdd:COG5048  262 RSSLPTaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                        330       340
                 ....*....|....*....|....*...
gi 153791870 557 HTRIHSGEKPYKC--NECGKAHNHLIDS 582
Cdd:COG5048  342 HILLHTSISPAKEklLNSSSKFSPLLNN 369
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-584 1.02e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 176 IANQVEKSVNDASSISTSQ-RISCRPETHTPNNYGNNFFHSslltqKQEVHMREKSFQCNETGEAFNcSSFVRKHQIIHL 254
Cdd:COG5048   55 SHTGEKPSQCSYSGCDKSFsRPLELSRHLRTHHNNPSDLNS-----KSLPLSNSKASSSSLSSSSSN-SNDNNLLSSHSL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 255 GEKQYKFDICGKVFNEKRYLARHRRCHTSEKPYKC----------NECGKSFSYKSSLTCHRRCHTGEKPYKCNECGKSF 324
Cdd:COG5048  129 PPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpaNSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSS 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 325 SYKSSLTCHHRCHTGEKPYKCNECGKSFSYKSSLRCHRRLHTGIKPYKCNECGKMFGQNSTLVIHKAIHTGE-------K 397
Cdd:COG5048  209 YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsL 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 398 PYKCNECGKAFNQQSHLSRH--HRLHTGE--KPYKC--NDCGKAFIHQSSLARHHRLHTGEKSYKCEECDRVFSQKSNLe 471
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL- 367

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 472 rhkiihtgekpykcNECHKTFSHRSSLPCHRRLHSGEKPYKCNECGKTFNVQSHLSRHHRLhtGEKPYKCKVCDKAFMCH 551
Cdd:COG5048  368 --------------NNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRH 431

                        410       420       430
                 ....*....|....*....|....*....|...
gi 153791870 552 SYLANHTRIHSGEKPYKCNECGKAHNHLIDSSI 584
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 423-506 2.02e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 423 GEKPYKCN--DCGKAFIHQSSLaRHHRLHTgeksykceECDRVFSQKSNLERHKIIHTGEKPYKCNECHKTFSHRSSLPC 500
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 153791870 501 HRRlHS 506
Cdd:COG5189  417 HRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
469-494 2.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.44e-04
                          10        20
                  ....*....|....*....|....*.
gi 153791870  469 NLERHKIIHTGEKPYKCNECHKTFSH 494
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-298 1.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.50e-03
                          10        20
                  ....*....|....*....|....*.
gi 153791870  273 YLARHRRCHTSEKPYKCNECGKSFSY 298
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
525-548 1.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.57e-03
                          10        20
                  ....*....|....*....|....
gi 153791870  525 HLSRHHRLHTGEKPYKCKVCDKAF 548
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
413-438 1.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.99e-03
                          10        20
                  ....*....|....*....|....*.
gi 153791870  413 HLSRHHRLHTGEKPYKCNDCGKAFIH 438
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
386-410 4.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.24e-03
                          10        20
                  ....*....|....*....|....*
gi 153791870  386 LVIHKAIHTGEKPYKCNECGKAFNQ 410
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 480-562 5.24e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 5.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791870 480 EKPYKCNECHKTFSHRSSL----PCHRRLHSGEKPYKCN--ECGKTFNVQSHLsRHHRLH-------------------- 533
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERnidtPSRMLKVKDGKPYKCPveGCNKKYKNQNGL-KYHMLHghqnqklhenpspekmnifs 393

                         90       100
                 ....*....|....*....|....*....
gi 153791870 534 TGEKPYKCKVCDKAFMCHSYLANHtRIHS 562
Cdd:COG5189  394 AKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
305-326 7.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.36e-03
                          10        20
                  ....*....|....*....|..
gi 153791870  305 HRRCHTGEKPYKCNECGKSFSY 326
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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