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Conserved domains on  [gi|156071452|ref|NP_001095132|]
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nardilysin isoform b precursor [Homo sapiens]

Protein Classification

M16 family metallopeptidase( domain architecture ID 1000463)

M16 family metallopeptidase is a zinc-dependent protease, similar to insulin-degrading enzyme (insulinase)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ptr super family cl34066
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
102-1089 0e+00

Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG1025:

Pssm-ID: 440648 [Multi-domain]  Cd Length: 956  Bit Score: 713.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  102 EIVKSPSDPKQYRYIKLQNGLQALLISDlsnmegktgnttddeeeeeveeeeedddedsgaeiedddeegfddedefdde 181
Cdd:COG1025    34 TIIKSPNDPRQYRAITLDNGLKVLLVSD---------------------------------------------------- 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  182 hdddldtedneleeleeraearkKTTEKqSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGG 261
Cdd:COG1025    62 -----------------------PQADK-SAAALAVPVGSFDDPDDQQGLAHFLEHMLFLGTKKYPEPGEYQEFISKHGG 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  262 SDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMG 341
Cdd:COG1025   118 SHNASTATERTNYYFEVENDALEEALDRFADFFAAPLFDPEYVDRERNAVNAEYTLKRSDDGRRIYQVHKETLNPAHPFS 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  342 KFFWGNAETLKhepRKNNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPnfghltdPFD 421
Cdd:COG1025   198 RFSVGNLETLS---DKPGSKLRDELLAFYQRYYSANLMKLVLYSNQSLDELEKLARQTFGAIPNRNLSVP-------PIT 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  422 TPAF-----NKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGNGETGfe 496
Cdd:COG1025   268 VPLYtpeqlGIIIHIVPLKPRRQLRLEFPIPNNQAYYRSKPLTYISYLLGNEGEGSLLDWLKKQGLAESLSAGGGISG-- 345
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  497 qnSTYSVFSISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIEDNEFHYQEQTDPVEYVENMCENMQLYP 576
Cdd:COG1025   346 --RNFGDFSISVSLTDKGLAHRDEIIAAVFAYIELIRQQGIQEWYFDEQAQLLELAFRFQEKTRPMDYVSWLSDNMLRYP 423
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  577 LQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGkcDLKEKWFGTQYSIEDIENSWAELWNsNFELNPDLHL 656
Cdd:COG1025   424 VEDVLDADYLMDGFDPAAIRARLAQLTPENARIWLISPDVPT--DKTAYWYDTPYSVDPITQEQLAKWQ-QASQNPALSL 500
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  657 PAENKYIATDFTLKAFDcPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNL 736
Cdd:COG1025   501 PELNPYIPDDFSLIKLD-KESAKPELLVDEPGLRLWYMPDQYFAEPKADIYLSLRNPQAVDSARNQVLTRLLDYLLNDAL 579
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  737 AEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTYFNilikpETLAKDV 816
Cdd:COG1025   580 NELSYQASVAGLSYSLYAHQGGLTLSASGFTQKQPKLLEALLDQLASFEPTEERFAQAKSQLLRQLDN-----AEKAKPY 654
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  817 RLLILEYARWSMIDKYQ-----ALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLnfKPLEQEMP 891
Cdd:COG1025   655 SQLFSPLSRLLQPPYFEreellAALESITLQDLRAFREQLLQQLHLEMLVVGNLSEEQAKQLADSLKKQL--APNGTGEE 732
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  892 VQFQVVELPSGHHLCKVKALNKGDanSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHV---YPTCRN 968
Cdd:COG1025   733 PRRQVVDLDKSGSLNLEKACDHTD--SALLIYYQSGYDSLASMALSSLLGQIISPWFFNQLRTEEQLGYVVgagYMPLGR 810
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  969 TSGIlGFSVtvgtQATKYNSEVVDKKIEEFLSSFEEKIENLTEEAFNTQVTALIK-LKEcEDTHLGEEVDRNWNEVVTQQ 1047
Cdd:COG1025   811 QPGL-GFYV----QSPVASPAYLLERIDDFLKQFEERLLALSEEEFAQYKQGLINqLLE-PDQNLSEEAQRLWVDIGNGD 884
                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|...
gi 156071452 1048 YLFDRLAHEIEALKSFSKSDLVNWFKAH-RGPGSKMLSVHVVG 1089
Cdd:COG1025   885 FEFDTREKLIAAVKKLTRADLIDFFQQAvIAPQGLRLLSQSQG 927
 
Name Accession Description Interval E-value
Ptr COG1025
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
102-1089 0e+00

Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440648 [Multi-domain]  Cd Length: 956  Bit Score: 713.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  102 EIVKSPSDPKQYRYIKLQNGLQALLISDlsnmegktgnttddeeeeeveeeeedddedsgaeiedddeegfddedefdde 181
Cdd:COG1025    34 TIIKSPNDPRQYRAITLDNGLKVLLVSD---------------------------------------------------- 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  182 hdddldtedneleeleeraearkKTTEKqSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGG 261
Cdd:COG1025    62 -----------------------PQADK-SAAALAVPVGSFDDPDDQQGLAHFLEHMLFLGTKKYPEPGEYQEFISKHGG 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  262 SDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMG 341
Cdd:COG1025   118 SHNASTATERTNYYFEVENDALEEALDRFADFFAAPLFDPEYVDRERNAVNAEYTLKRSDDGRRIYQVHKETLNPAHPFS 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  342 KFFWGNAETLKhepRKNNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPnfghltdPFD 421
Cdd:COG1025   198 RFSVGNLETLS---DKPGSKLRDELLAFYQRYYSANLMKLVLYSNQSLDELEKLARQTFGAIPNRNLSVP-------PIT 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  422 TPAF-----NKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGNGETGfe 496
Cdd:COG1025   268 VPLYtpeqlGIIIHIVPLKPRRQLRLEFPIPNNQAYYRSKPLTYISYLLGNEGEGSLLDWLKKQGLAESLSAGGGISG-- 345
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  497 qnSTYSVFSISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIEDNEFHYQEQTDPVEYVENMCENMQLYP 576
Cdd:COG1025   346 --RNFGDFSISVSLTDKGLAHRDEIIAAVFAYIELIRQQGIQEWYFDEQAQLLELAFRFQEKTRPMDYVSWLSDNMLRYP 423
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  577 LQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGkcDLKEKWFGTQYSIEDIENSWAELWNsNFELNPDLHL 656
Cdd:COG1025   424 VEDVLDADYLMDGFDPAAIRARLAQLTPENARIWLISPDVPT--DKTAYWYDTPYSVDPITQEQLAKWQ-QASQNPALSL 500
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  657 PAENKYIATDFTLKAFDcPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNL 736
Cdd:COG1025   501 PELNPYIPDDFSLIKLD-KESAKPELLVDEPGLRLWYMPDQYFAEPKADIYLSLRNPQAVDSARNQVLTRLLDYLLNDAL 579
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  737 AEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTYFNilikpETLAKDV 816
Cdd:COG1025   580 NELSYQASVAGLSYSLYAHQGGLTLSASGFTQKQPKLLEALLDQLASFEPTEERFAQAKSQLLRQLDN-----AEKAKPY 654
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  817 RLLILEYARWSMIDKYQ-----ALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLnfKPLEQEMP 891
Cdd:COG1025   655 SQLFSPLSRLLQPPYFEreellAALESITLQDLRAFREQLLQQLHLEMLVVGNLSEEQAKQLADSLKKQL--APNGTGEE 732
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  892 VQFQVVELPSGHHLCKVKALNKGDanSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHV---YPTCRN 968
Cdd:COG1025   733 PRRQVVDLDKSGSLNLEKACDHTD--SALLIYYQSGYDSLASMALSSLLGQIISPWFFNQLRTEEQLGYVVgagYMPLGR 810
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  969 TSGIlGFSVtvgtQATKYNSEVVDKKIEEFLSSFEEKIENLTEEAFNTQVTALIK-LKEcEDTHLGEEVDRNWNEVVTQQ 1047
Cdd:COG1025   811 QPGL-GFYV----QSPVASPAYLLERIDDFLKQFEERLLALSEEEFAQYKQGLINqLLE-PDQNLSEEAQRLWVDIGNGD 884
                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|...
gi 156071452 1048 YLFDRLAHEIEALKSFSKSDLVNWFKAH-RGPGSKMLSVHVVG 1089
Cdd:COG1025   885 FEFDTREKLIAAVKKLTRADLIDFFQQAvIAPQGLRLLSQSQG 927
Peptidase_M16_M pfam16187
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
553-834 4.36e-122

Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.


Pssm-ID: 465051 [Multi-domain]  Cd Length: 284  Bit Score: 376.91  E-value: 4.36e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   553 FHYQEQTDPVEYVENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYS 632
Cdd:pfam16187    1 FRFQEKSPPSDYVSSLASNMQPYPPEDILSGDYLLREYDPELIQELLDYLTPENARITLVSKEFEGETDQKEPWYGTEYS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   633 IEDIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFDCPE-TEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLI 711
Cdd:pfam16187   81 VEPIPEELLKKWKNAPEPNPELHLPEPNPFIPTDFDLKKKEVKEpAKYPVLIRDTPLSRLWYKKDDTFWVPKANIYLSLR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   712 SPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVF 791
Cdd:pfam16187  161 SPLAYSSPRNAVLTRLYVELLKDSLNEYAYDAELAGLSYSLSATERGLTLSVSGYNDKLPVLLEKILEKLRDFEIDPDRF 240
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 156071452   792 TMITEQLKKTYFN-ILIKPETLAKDVRLLILEYARWSMIDKYQA 834
Cdd:pfam16187  241 EIIKEQLLRSYKNfALEQPYQQAFDYLLYLLEERSWTPEEKLEA 284
PRK15101 PRK15101
protease3; Provisional
103-1073 8.62e-107

protease3; Provisional


Pssm-ID: 185056 [Multi-domain]  Cd Length: 961  Bit Score: 358.14  E-value: 8.62e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  103 IVKSPSDPKQYRYIKLQNGLQALLISDlsnmegktgnttddeeeeeveeeeedddedsgaeiedddeegfddedefddeh 182
Cdd:PRK15101   34 IRKSEKDPRQYQAIRLDNGMTVLLVSD----------------------------------------------------- 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  183 dddldtedneleeleeraearKKTTekQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGS 262
Cdd:PRK15101   61 ---------------------PQAV--KSLAALALPVGSLEDPDAQQGLAHYLEHMVLMGSKKYPQPDSLAEFLKKHGGS 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  263 DNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGK 342
Cdd:PRK15101  118 HNASTASYRTAFYLEVENDALPPAVDRLADAIAEPLLDPKNADRERNAVNAELTMARSRDGMRMAQVSAETINPAHPGSR 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  343 FFWGNAETLKHEPrknNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPNfghLTDPFDT 422
Cdd:PRK15101  198 FSGGNLETLSDKP---GSKLQDALVDFYQRYYSANLMKAVIYSNQPLPELAKLAADTFGRVPNKNASVPE---ITVPVVT 271
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  423 PAfNK--LYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGnGETGFEQNSt 500
Cdd:PRK15101  272 DA-QKgiIIHYVPAQPRKVLRVEFRIDNNSAKFRSKTDEYISYLIGNRSPGTLSDWLQKQGLAEGISAG-ADPMVDRNS- 348
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  501 ySVFSISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQDI 580
Cdd:PRK15101  349 -GVFAISVSLTDKGLAQRDQVVAAIFSYLNLLREKGIDKSYFDELAHVLDLDFRYPSITRDMDYIEWLADTMLRVPVEHT 427
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  581 LTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSgaNEGKCDLKEKWFGTQYSIEDIENSWAELWNsNFELNPDLHLPAEN 660
Cdd:PRK15101  428 LDAPYIADRYDPKAIKARLAEMTPQNARIWYIS--PQEPHNKTAYFVDAPYQVDKISEQTFADWQ-QKAQNIALSLPELN 504
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  661 KYIATDFTLKAFDcPETEYPVKIVNTPQGCLWYKKDNKF-KIPKAYIRFHLISPLIQKSAANVVLF---DIFVNIlthNL 736
Cdd:PRK15101  505 PYIPDDFSLIKAD-KAYKHPELIVDEPGLRVVYMPSQYFaDEPKADISLVLRNPKAMDSARNQVLFalnDYLAGL---AL 580
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  737 AEPAYEADVAQLEYKLVAGEhGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFtmitEQLKKTYFNILIKPETlAKDV 816
Cdd:PRK15101  581 DQLSNQASVGGISFSTNANN-GLMVNANGYTQRLPQLLQALLEGYFSFTPTEEQL----AQAKSWYREQLDSAEK-GKAY 654
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  817 RLLILEYARWSMI-----DKYQALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFK------- 884
Cdd:PRK15101  655 EQAIMPAQMLSQVpyferDERRKLLPSITLKDVLAYRDALLSGATPEFLVVGNLTEEQVTTLARDVQKQLGADgtewwrg 734
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  885 ---PLEQEMPVQFQvvelpsghhlckvKALNKGD-ANSEVTV---Y--YQSGTRSlreytlmeLLVMHMEEPCF-DFLRT 954
Cdd:PRK15101  735 kdvVVDKKQSVNFE-------------KAGSSTDsALAAVYVptgYdeYQSSAYS--------SLLGQIIQPWFyNQLRT 793
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  955 KQTLGYHVYPTcrNTS-----GIlGFSVTVGTQATKYnsevVDKKIEEFLSSFEEKIENLTEEAFNTQVTALI-KLKECE 1028
Cdd:PRK15101  794 EEQLGYAVFAF--PMSvgrqwGM-GFLLQSNDKQPAY----LWQRYQAFFPQAEAKLRAMKPEEFAQYQQALInQLLQAP 866
                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|....*
gi 156071452 1029 DThLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVNWFK 1073
Cdd:PRK15101  867 QT-LGEEASRLSKDFDRGNMRFDSRDKIIAQIKLLTPQKLADFFH 910
PQQ_syn_pqqF TIGR02110
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
209-411 5.22e-32

coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 273978 [Multi-domain]  Cd Length: 697  Bit Score: 134.23  E-value: 5.22e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   209 KQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALD 288
Cdd:TIGR02110   20 KRAAALLRVAAGSHDEPSAWPGLAHFLEHLLFLGGERFQGDDRLMPWVQRQGGQVNATTLERTTAFFFELPAAALAAGLA 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   289 RWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKheprKNNIDTHARLRE 368
Cdd:TIGR02110  100 RLCDMLARPLLTAEDQQREREVLEAEYIAWQNDADTLREAALLDALQAGHPLRRFHAGSRDSLA----LPNTAFQQALRD 175
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 156071452   369 FWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRP 411
Cdd:TIGR02110  176 FHRRHYQAGNMQLWLQGPQSLDELEQLAARFGASLAAGGECAQ 218
 
Name Accession Description Interval E-value
Ptr COG1025
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
102-1089 0e+00

Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440648 [Multi-domain]  Cd Length: 956  Bit Score: 713.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  102 EIVKSPSDPKQYRYIKLQNGLQALLISDlsnmegktgnttddeeeeeveeeeedddedsgaeiedddeegfddedefdde 181
Cdd:COG1025    34 TIIKSPNDPRQYRAITLDNGLKVLLVSD---------------------------------------------------- 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  182 hdddldtedneleeleeraearkKTTEKqSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGG 261
Cdd:COG1025    62 -----------------------PQADK-SAAALAVPVGSFDDPDDQQGLAHFLEHMLFLGTKKYPEPGEYQEFISKHGG 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  262 SDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMG 341
Cdd:COG1025   118 SHNASTATERTNYYFEVENDALEEALDRFADFFAAPLFDPEYVDRERNAVNAEYTLKRSDDGRRIYQVHKETLNPAHPFS 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  342 KFFWGNAETLKhepRKNNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPnfghltdPFD 421
Cdd:COG1025   198 RFSVGNLETLS---DKPGSKLRDELLAFYQRYYSANLMKLVLYSNQSLDELEKLARQTFGAIPNRNLSVP-------PIT 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  422 TPAF-----NKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGNGETGfe 496
Cdd:COG1025   268 VPLYtpeqlGIIIHIVPLKPRRQLRLEFPIPNNQAYYRSKPLTYISYLLGNEGEGSLLDWLKKQGLAESLSAGGGISG-- 345
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  497 qnSTYSVFSISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIEDNEFHYQEQTDPVEYVENMCENMQLYP 576
Cdd:COG1025   346 --RNFGDFSISVSLTDKGLAHRDEIIAAVFAYIELIRQQGIQEWYFDEQAQLLELAFRFQEKTRPMDYVSWLSDNMLRYP 423
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  577 LQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGkcDLKEKWFGTQYSIEDIENSWAELWNsNFELNPDLHL 656
Cdd:COG1025   424 VEDVLDADYLMDGFDPAAIRARLAQLTPENARIWLISPDVPT--DKTAYWYDTPYSVDPITQEQLAKWQ-QASQNPALSL 500
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  657 PAENKYIATDFTLKAFDcPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNL 736
Cdd:COG1025   501 PELNPYIPDDFSLIKLD-KESAKPELLVDEPGLRLWYMPDQYFAEPKADIYLSLRNPQAVDSARNQVLTRLLDYLLNDAL 579
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  737 AEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTYFNilikpETLAKDV 816
Cdd:COG1025   580 NELSYQASVAGLSYSLYAHQGGLTLSASGFTQKQPKLLEALLDQLASFEPTEERFAQAKSQLLRQLDN-----AEKAKPY 654
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  817 RLLILEYARWSMIDKYQ-----ALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLnfKPLEQEMP 891
Cdd:COG1025   655 SQLFSPLSRLLQPPYFEreellAALESITLQDLRAFREQLLQQLHLEMLVVGNLSEEQAKQLADSLKKQL--APNGTGEE 732
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  892 VQFQVVELPSGHHLCKVKALNKGDanSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHV---YPTCRN 968
Cdd:COG1025   733 PRRQVVDLDKSGSLNLEKACDHTD--SALLIYYQSGYDSLASMALSSLLGQIISPWFFNQLRTEEQLGYVVgagYMPLGR 810
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  969 TSGIlGFSVtvgtQATKYNSEVVDKKIEEFLSSFEEKIENLTEEAFNTQVTALIK-LKEcEDTHLGEEVDRNWNEVVTQQ 1047
Cdd:COG1025   811 QPGL-GFYV----QSPVASPAYLLERIDDFLKQFEERLLALSEEEFAQYKQGLINqLLE-PDQNLSEEAQRLWVDIGNGD 884
                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|...
gi 156071452 1048 YLFDRLAHEIEALKSFSKSDLVNWFKAH-RGPGSKMLSVHVVG 1089
Cdd:COG1025   885 FEFDTREKLIAAVKKLTRADLIDFFQQAvIAPQGLRLLSQSQG 927
Peptidase_M16_M pfam16187
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
553-834 4.36e-122

Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.


Pssm-ID: 465051 [Multi-domain]  Cd Length: 284  Bit Score: 376.91  E-value: 4.36e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   553 FHYQEQTDPVEYVENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYS 632
Cdd:pfam16187    1 FRFQEKSPPSDYVSSLASNMQPYPPEDILSGDYLLREYDPELIQELLDYLTPENARITLVSKEFEGETDQKEPWYGTEYS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   633 IEDIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFDCPE-TEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLI 711
Cdd:pfam16187   81 VEPIPEELLKKWKNAPEPNPELHLPEPNPFIPTDFDLKKKEVKEpAKYPVLIRDTPLSRLWYKKDDTFWVPKANIYLSLR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   712 SPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVF 791
Cdd:pfam16187  161 SPLAYSSPRNAVLTRLYVELLKDSLNEYAYDAELAGLSYSLSATERGLTLSVSGYNDKLPVLLEKILEKLRDFEIDPDRF 240
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 156071452   792 TMITEQLKKTYFN-ILIKPETLAKDVRLLILEYARWSMIDKYQA 834
Cdd:pfam16187  241 EIIKEQLLRSYKNfALEQPYQQAFDYLLYLLEERSWTPEEKLEA 284
PRK15101 PRK15101
protease3; Provisional
103-1073 8.62e-107

protease3; Provisional


Pssm-ID: 185056 [Multi-domain]  Cd Length: 961  Bit Score: 358.14  E-value: 8.62e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  103 IVKSPSDPKQYRYIKLQNGLQALLISDlsnmegktgnttddeeeeeveeeeedddedsgaeiedddeegfddedefddeh 182
Cdd:PRK15101   34 IRKSEKDPRQYQAIRLDNGMTVLLVSD----------------------------------------------------- 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  183 dddldtedneleeleeraearKKTTekQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGS 262
Cdd:PRK15101   61 ---------------------PQAV--KSLAALALPVGSLEDPDAQQGLAHYLEHMVLMGSKKYPQPDSLAEFLKKHGGS 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  263 DNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGK 342
Cdd:PRK15101  118 HNASTASYRTAFYLEVENDALPPAVDRLADAIAEPLLDPKNADRERNAVNAELTMARSRDGMRMAQVSAETINPAHPGSR 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  343 FFWGNAETLKHEPrknNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPNfghLTDPFDT 422
Cdd:PRK15101  198 FSGGNLETLSDKP---GSKLQDALVDFYQRYYSANLMKAVIYSNQPLPELAKLAADTFGRVPNKNASVPE---ITVPVVT 271
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  423 PAfNK--LYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGnGETGFEQNSt 500
Cdd:PRK15101  272 DA-QKgiIIHYVPAQPRKVLRVEFRIDNNSAKFRSKTDEYISYLIGNRSPGTLSDWLQKQGLAEGISAG-ADPMVDRNS- 348
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  501 ySVFSISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQDI 580
Cdd:PRK15101  349 -GVFAISVSLTDKGLAQRDQVVAAIFSYLNLLREKGIDKSYFDELAHVLDLDFRYPSITRDMDYIEWLADTMLRVPVEHT 427
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  581 LTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSgaNEGKCDLKEKWFGTQYSIEDIENSWAELWNsNFELNPDLHLPAEN 660
Cdd:PRK15101  428 LDAPYIADRYDPKAIKARLAEMTPQNARIWYIS--PQEPHNKTAYFVDAPYQVDKISEQTFADWQ-QKAQNIALSLPELN 504
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  661 KYIATDFTLKAFDcPETEYPVKIVNTPQGCLWYKKDNKF-KIPKAYIRFHLISPLIQKSAANVVLF---DIFVNIlthNL 736
Cdd:PRK15101  505 PYIPDDFSLIKAD-KAYKHPELIVDEPGLRVVYMPSQYFaDEPKADISLVLRNPKAMDSARNQVLFalnDYLAGL---AL 580
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  737 AEPAYEADVAQLEYKLVAGEhGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFtmitEQLKKTYFNILIKPETlAKDV 816
Cdd:PRK15101  581 DQLSNQASVGGISFSTNANN-GLMVNANGYTQRLPQLLQALLEGYFSFTPTEEQL----AQAKSWYREQLDSAEK-GKAY 654
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  817 RLLILEYARWSMI-----DKYQALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFK------- 884
Cdd:PRK15101  655 EQAIMPAQMLSQVpyferDERRKLLPSITLKDVLAYRDALLSGATPEFLVVGNLTEEQVTTLARDVQKQLGADgtewwrg 734
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  885 ---PLEQEMPVQFQvvelpsghhlckvKALNKGD-ANSEVTV---Y--YQSGTRSlreytlmeLLVMHMEEPCF-DFLRT 954
Cdd:PRK15101  735 kdvVVDKKQSVNFE-------------KAGSSTDsALAAVYVptgYdeYQSSAYS--------SLLGQIIQPWFyNQLRT 793
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  955 KQTLGYHVYPTcrNTS-----GIlGFSVTVGTQATKYnsevVDKKIEEFLSSFEEKIENLTEEAFNTQVTALI-KLKECE 1028
Cdd:PRK15101  794 EEQLGYAVFAF--PMSvgrqwGM-GFLLQSNDKQPAY----LWQRYQAFFPQAEAKLRAMKPEEFAQYQQALInQLLQAP 866
                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|....*
gi 156071452 1029 DThLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVNWFK 1073
Cdd:PRK15101  867 QT-LGEEASRLSKDFDRGNMRFDSRDKIIAQIKLLTPQKLADFFH 910
Peptidase_M16 pfam00675
Insulinase (Peptidase family M16);
205-337 1.50e-45

Insulinase (Peptidase family M16);


Pssm-ID: 425812 [Multi-domain]  Cd Length: 149  Bit Score: 160.93  E-value: 1.50e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   205 KTTEKQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDeNGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFK 284
Cdd:pfam00675    7 DPPADTSTVGLWIDAGSRYEPDNNNGLAHFLEHMAFKGTKKYPS-NELEEELEKLGGSLNAFTSRENTVYYAEVLNDDLP 85
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156071452   285 EALDRWAQFFIHPLMIRDAIDR-------EVEAVDSEYQL----ARPSDANRKEMLFGSLARPG 337
Cdd:pfam00675   86 KAVDRLADFFRNPLFTESEIERerlvvlyEVEAVDSEPQLvvleNLHAAAYRNTPLGRSLLGPG 149
PQQ_syn_pqqF TIGR02110
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
209-411 5.22e-32

coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 273978 [Multi-domain]  Cd Length: 697  Bit Score: 134.23  E-value: 5.22e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   209 KQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALD 288
Cdd:TIGR02110   20 KRAAALLRVAAGSHDEPSAWPGLAHFLEHLLFLGGERFQGDDRLMPWVQRQGGQVNATTLERTTAFFFELPAAALAAGLA 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   289 RWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKheprKNNIDTHARLRE 368
Cdd:TIGR02110  100 RLCDMLARPLLTAEDQQREREVLEAEYIAWQNDADTLREAALLDALQAGHPLRRFHAGSRDSLA----LPNTAFQQALRD 175
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 156071452   369 FWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRP 411
Cdd:TIGR02110  176 FHRRHYQAGNMQLWLQGPQSLDELEQLAARFGASLAAGGECAQ 218
PqqL COG0612
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
212-553 7.63e-29

Predicted Zn-dependent peptidase, M16 family [General function prediction only];


Pssm-ID: 440377 [Multi-domain]  Cd Length: 427  Bit Score: 120.80  E-value: 7.63e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  212 AAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPdENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWA 291
Cdd:COG0612    38 SVRLWVRVGSRDEPPGKTGLAHFLEHMLFKGTKKRS-AGEIAEELEALGGSLNAFTSFDYTVYYLSVLSEDLELALELLA 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  292 QFFIHPLMIRDAIDREVEAVDSEYQ--LARPSDANRKEMLfgSLARPGHPMGKFFWGNAETLKheprknNIdTHARLREF 369
Cdd:COG0612   117 DRLLNPTFDEEELERERGVVLEEIRryEDDPDGLAFEALL--AALYGDHPYGRPIIGTEESIE------AI-TREDLRAF 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  370 WMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPnfghlTDPFDTPAFNKLYRVVPIRKIHALTITWALP-P 448
Cdd:COG0612   188 YKRYYRPNNAVLVVVGDVDPEEVLALVEKYFGDLPAGPAPPR-----PDPAEPPQTGPRRVVVDDPDAEQAHILLGYPgP 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452  449 QQQHYRVKPLHYISWLVGHeGKGSILsF--LR-KKCWALALFGgngetGFEQNSTYSVFSISITLTDEGYEHFyevaytv 525
Cdd:COG0612   263 ARDDPDYYALDVLNEILGG-GFSSRL-FqeLReKKGLAYSVGS-----SFSPYRDAGLFTIYAGTAPDKLEEA------- 328
                         330       340
                  ....*....|....*....|....*...
gi 156071452  526 fqylkmlqklgpEKRIFEEIRKIEDNEF 553
Cdd:COG0612   329 ------------LAAILEELERLAKEGV 344
Peptidase_M16_C pfam05193
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
362-548 3.82e-28

Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.


Pssm-ID: 428362 [Multi-domain]  Cd Length: 181  Bit Score: 112.10  E-value: 3.82e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   362 THARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNglprpNFGHLTDPFDTPAFNKLYRVVPIRK---IH 438
Cdd:pfam05193    3 TREDLRDFYKKHYSPDNMVLVIVGDVDHEELLDLAEKYFGDLPAS-----PKGKPRPPPLEPAKLKGREVVVPKKdepQA 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   439 ALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSFLR-KKCWALALFGGNgetgfEQNSTYSVFSISITLTDegyEH 517
Cdd:pfam05193   78 HLALAFPGPPLNNDEDSLALDVLNELLGGGMSSRLFQELReKEGLAYSVSSFN-----DSYSDSGLFGIYATVDP---EN 149
                          170       180       190
                   ....*....|....*....|....*....|.
gi 156071452   518 FYEVAYTVFQYLKMLQKLGPEKRIFEEIRKI 548
Cdd:pfam05193  150 VDEVIELILEELEKLAQEGVTEEELERAKNQ 180
Peptidase_M16_C pfam05193
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
839-1021 9.38e-14

Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.


Pssm-ID: 428362 [Multi-domain]  Cd Length: 181  Bit Score: 70.88  E-value: 9.38e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   839 LSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFKPleqemPVQFQVVELPSGHHLCKVKALNKGDAN- 917
Cdd:pfam05193    2 LTREDLRDFYKKHYSPDNMVLVIVGDVDHEELLDLAEKYFGDLPASP-----KGKPRPPPLEPAKLKGREVVVPKKDEPq 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156071452   918 SEVTVYYQS-GTRSLREYTLMELLVMHMEE----PCFDFLRTKQTLGYHVYPTCRNTS--GILGFSVTVgtqatkyNSEV 990
Cdd:pfam05193   77 AHLALAFPGpPLNNDEDSLALDVLNELLGGgmssRLFQELREKEGLAYSVSSFNDSYSdsGLFGIYATV-------DPEN 149
                          170       180       190
                   ....*....|....*....|....*....|..
gi 156071452   991 VDKKIEEFLSSFEEKIEN-LTEEAFNTQVTAL 1021
Cdd:pfam05193  150 VDEVIELILEELEKLAQEgVTEEELERAKNQL 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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