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Conserved domains on  [gi|159110675|ref|NP_001103724|]
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uncharacterized protein LOC240041 isoform a [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 33-73 5.56e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 5.56e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 159110675   33 LLTFKEVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFV 73
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
397-786 3.17e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 3.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 397 NTYKCSECDKCFTQRCLLRTHQRIHSGEKPYKCSECGKAFAGGSY--LRSHQRIHSEKKPYKCSDCDKSFHRK-DHLRIH 473
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKaSSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 474 QRIHTGEKPYKCSECDKCFTQKGSVRIHQRIHTGEKPYKCSKCDKSFTKKD-CLKIHQIIHTGEEPykcsecdTSFNRKD 552
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 553 HLRTHQRFHTGERIYKCSECDESFTQKINLRIHQKIHTGDNSYKCS----GCDKSFNRRNHLRTHERIHAGEKPYNCREF 628
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTtnsqLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 629 --ENSFIQTGSLRIHQRLHSRKKL-YKCRECDKSFTSSSYVRIHQR--IHSGE--KPYKCSE--CGKCFTSGSYLRMHQR 699
Cdd:COG5048  265 lpTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 700 IHTGDKPYKC------SDCDKCFTQKCSLRIHQRSHTGEKPYKCG---NCDRSFTSGSYLRIHQRIHRGEKPH--KCSEC 768
Cdd:COG5048  345 LHTSISPAKEkllnssSKFSPLLNNEPPQSLQQYKDLKNDKKSETlsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPC 424

                        410
                 ....*....|....*...
gi 159110675 769 DKSFTQKGYLRIHQRIHK 786
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
358-382 7.71e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.71e-03
                          10        20
                  ....*....|....*....|....*
gi 159110675  358 LKIHQRIHTGERPYKCGDCDKSFTQ 382
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 33-73 5.56e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 5.56e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 159110675   33 LLTFKEVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFV 73
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
34-92 8.16e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.41  E-value: 8.16e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 159110675    34 LTFKEVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFVEnnHHVCvKHDEV--LGQGSK 92
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG--FQVP-KPDLIsqLEQGEE 58
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 34-72 2.33e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 2.33e-17
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 159110675  34 LTFKEVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLF 72
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
397-786 3.17e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 3.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 397 NTYKCSECDKCFTQRCLLRTHQRIHSGEKPYKCSECGKAFAGGSY--LRSHQRIHSEKKPYKCSDCDKSFHRK-DHLRIH 473
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKaSSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 474 QRIHTGEKPYKCSECDKCFTQKGSVRIHQRIHTGEKPYKCSKCDKSFTKKD-CLKIHQIIHTGEEPykcsecdTSFNRKD 552
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 553 HLRTHQRFHTGERIYKCSECDESFTQKINLRIHQKIHTGDNSYKCS----GCDKSFNRRNHLRTHERIHAGEKPYNCREF 628
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTtnsqLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 629 --ENSFIQTGSLRIHQRLHSRKKL-YKCRECDKSFTSSSYVRIHQR--IHSGE--KPYKCSE--CGKCFTSGSYLRMHQR 699
Cdd:COG5048  265 lpTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 700 IHTGDKPYKC------SDCDKCFTQKCSLRIHQRSHTGEKPYKCG---NCDRSFTSGSYLRIHQRIHRGEKPH--KCSEC 768
Cdd:COG5048  345 LHTSISPAKEkllnssSKFSPLLNNEPPQSLQQYKDLKNDKKSETlsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPC 424

                        410
                 ....*....|....*...
gi 159110675 769 DKSFTQKGYLRIHQRIHK 786
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
469-494 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|....*.
gi 159110675  469 HLRIHQRIHTGEKPYKCSECDKCFTQ 494
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
358-382 7.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.71e-03
                          10        20
                  ....*....|....*....|....*
gi 159110675  358 LKIHQRIHTGERPYKCGDCDKSFTQ 382
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 33-73 5.56e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 5.56e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 159110675   33 LLTFKEVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFV 73
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
34-92 8.16e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.41  E-value: 8.16e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 159110675    34 LTFKEVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFVEnnHHVCvKHDEV--LGQGSK 92
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG--FQVP-KPDLIsqLEQGEE 58
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 34-72 2.33e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 2.33e-17
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 159110675  34 LTFKEVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLF 72
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
397-786 3.17e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 3.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 397 NTYKCSECDKCFTQRCLLRTHQRIHSGEKPYKCSECGKAFAGGSY--LRSHQRIHSEKKPYKCSDCDKSFHRK-DHLRIH 473
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKaSSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 474 QRIHTGEKPYKCSECDKCFTQKGSVRIHQRIHTGEKPYKCSKCDKSFTKKD-CLKIHQIIHTGEEPykcsecdTSFNRKD 552
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 553 HLRTHQRFHTGERIYKCSECDESFTQKINLRIHQKIHTGDNSYKCS----GCDKSFNRRNHLRTHERIHAGEKPYNCREF 628
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTtnsqLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 629 --ENSFIQTGSLRIHQRLHSRKKL-YKCRECDKSFTSSSYVRIHQR--IHSGE--KPYKCSE--CGKCFTSGSYLRMHQR 699
Cdd:COG5048  265 lpTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 700 IHTGDKPYKC------SDCDKCFTQKCSLRIHQRSHTGEKPYKCG---NCDRSFTSGSYLRIHQRIHRGEKPH--KCSEC 768
Cdd:COG5048  345 LHTSISPAKEkllnssSKFSPLLNNEPPQSLQQYKDLKNDKKSETlsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPC 424

                        410
                 ....*....|....*...
gi 159110675 769 DKSFTQKGYLRIHQRIHK 786
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
340-754 8.36e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 8.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 340 KKCYRCKECGKSLSTSSGLKIHQRIHTGERPYKCGD--CDKSFTQKSNLRMHQKIHTGENTYKCSecDKCFTQRCLLRTH 417
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 418 QRIHSGE---KPYKCSECGKAFAGGSYLRSHQRIHSEKKPYKCSDCDKSFHRKD-HLRIHQRIHTGEKPYKCSECDkcft 493
Cdd:COG5048  109 SLSSSSSnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLSKDPSSNL---- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 494 qkgSVRIHQRIHTGEKPYKCSKCDKSFTKKDCLKIHQIIHTGEEPYKCSECdtSFNRKDHLRTHQRFHTGERIYK--CSE 571
Cdd:COG5048  185 ---SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSssASE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 572 CDESFTQKINLRIHQKIHTG-------DNSYKCSGCDKSFNRRNHLRTHER--IHAGE--KPYNCREFENS--FIQTGSL 638
Cdd:COG5048  260 SPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGklFSRNDAL 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 639 RIHQRLHSRKKLYKC--RECDKSFTSSSYVRIHQRI--HSGEKPYKCSEC--GKC---FTSGSYLRMHQRIHTGDKP--Y 707
Cdd:COG5048  340 KRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETlsNSCirnFKRDSNLSLHIITHLSFRPynC 419

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 159110675 708 KCSDCDKCFTQKCSLRIHQRSHTGEKPYKCGNCDRSFTSGSYLRIHQ 754
Cdd:COG5048  420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
182-613 8.73e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 8.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 182 DEAFLSKYKLMLKGNNSGMKSHKCRKSGKFFTMTSSLSGHPRDHAREKPYQCT----KCSKSFLHLSHlQLHYKIHFGGY 257
Cdd:COG5048   13 NSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysgcDKSFSRPLELS-RHLRTHHNNPS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 258 PYKCTECGKCFYHASGFErhcRIHATKNTYKCSFCSKSFICCSGLRKHQKIHEENRLFECNQDTRsfCTFSYRECHYRAD 337
Cdd:COG5048   92 DLNSKSLPLSNSKASSSS---LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPG--NNSSSVNTPQSNS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 338 IRKKCyRCKECGKSLSTSSGLKIHQRIHTGERPYKCGDCDKSFTQKSNLRMHQKIHTGENTYKCSECDKCFTQRCLLRTH 417
Cdd:COG5048  167 LHPPL-PANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 418 QRIHSGEKPYKCSECGKAFAG--GSYLRSHQRIHSEK-----KPYKCSDCDKSFHRKDHLRIHQR--IHTGE--KPYKCS 486
Cdd:COG5048  246 SSLSSSDSSSSASESPRSSLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCP 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 487 E--CDKCFTQKGSVRIHQRIHTGEKPYKC------SKCDKSFTKKDCLKIHQIIHTGEEPYKC---SECDTSFNRKDHLR 555
Cdd:COG5048  326 YslCGKLFSRNDALKRHILLHTSISPAKEkllnssSKFSPLLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLS 405

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 556 THQRFHTGERI--YKCSECDESFTQKINLRIHQKIHTGDNSYKCSGCdKSFNRRNHLRTH 613
Cdd:COG5048  406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
469-494 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|....*.
gi 159110675  469 HLRIHQRIHTGEKPYKCSECDKCFTQ 494
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 367-450 1.30e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110675 367 GERPYKCG--DCDKSFTQKSNLRMHQKI-HTGENTYKCSECDKcftqrcllrtHQRIHSGEKPYKCSECGKAFAGGSYLR 443
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 159110675 444 SHqRIHS 450
Cdd:COG5189  416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
693-718 2.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 159110675  693 YLRMHQRIHTGDKPYKCSDCDKCFTQ 718
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
749-774 2.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.80e-03
                          10        20
                  ....*....|....*....|....*.
gi 159110675  749 YLRIHQRIHRGEKPHKCSECDKSFTQ 774
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-437 3.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.69e-03
                          10        20
                  ....*....|....*....|....
gi 159110675  414 LRTHQRIHSGEKPYKCSECGKAFA 437
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 453-529 4.89e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 4.89e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 159110675 453 KPYKCS--DCDKSFHRKDHLRIHqRIHtgekpykcSECDKCFTQKGSVRIHQRIHTGEKPYKCSKCDKSFTKKDCLKIH 529
Cdd:COG5189  348 KPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
358-382 7.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.71e-03
                          10        20
                  ....*....|....*....|....*
gi 159110675  358 LKIHQRIHTGERPYKCGDCDKSFTQ 382
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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