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Conserved domains on  [gi|160358817|ref|NP_001103738|]
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vascular endothelial growth factor A, long form isoform 6 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF super family cl00116
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 27-54 2.61e-07

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


The actual alignment was detected with superfamily member smart00141:

Pssm-ID: 444701  Cd Length: 83  Bit Score: 43.18  E-value: 2.61e-07
                          10        20
                  ....*....|....*....|....*...
gi 160358817   27 QIMRIKPHQSQHIGEMSFLQHSRCECRP 54
Cdd:smart00141 56 QLLEISRPLSQHLVEVSFEEHTKCECRP 83
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 27-54 2.61e-07

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 43.18  E-value: 2.61e-07
                          10        20
                  ....*....|....*....|....*...
gi 160358817   27 QIMRIKPHQSQHIGEMSFLQHSRCECRP 54
Cdd:smart00141 56 QLLEISRPLSQHLVEVSFEEHTKCECRP 83
PDGF pfam00341
PDGF/VEGF domain;
25-52 2.04e-03

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 33.03  E-value: 2.04e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 160358817  25 PLQIMRIK---PHQSQHIGEMSFLQHSRCEC 52
Cdd:pfam00341 52 TMQVLKIEyapRRPSPELVEVSFEEHVQCEC 82
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 27-54 2.61e-07

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 43.18  E-value: 2.61e-07
                          10        20
                  ....*....|....*....|....*...
gi 160358817   27 QIMRIKPHQSQHIGEMSFLQHSRCECRP 54
Cdd:smart00141 56 QLLEISRPLSQHLVEVSFEEHTKCECRP 83
PDGF pfam00341
PDGF/VEGF domain;
25-52 2.04e-03

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 33.03  E-value: 2.04e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 160358817  25 PLQIMRIK---PHQSQHIGEMSFLQHSRCEC 52
Cdd:pfam00341 52 TMQVLKIEyapRRPSPELVEVSFEEHVQCEC 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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