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Conserved domains on  [gi|164519071|ref|NP_001106801|]
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cone-rod homeobox protein isoform 2 [Mus musculus]

Protein Classification

homeodomain and TF_Otx domain-containing protein( domain architecture ID 11078768)

homeodomain and TF_Otx domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
64-117 1.58e-26

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 1.58e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 164519071   64 RRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAK 117
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
TF_Otx super family cl04137
Otx1 transcription factor;
188-273 1.88e-11

Otx1 transcription factor;


The actual alignment was detected with superfamily member pfam03529:

Pssm-ID: 427350  Cd Length: 91  Bit Score: 59.54  E-value: 1.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164519071  188 SPASEAPLPEAQRAGLVA----SGPSLTSAPYAMTYAPASAFCSSPSAYASPSsyFSGLD--PYLSPMVPQLGGP-ALSP 260
Cdd:pfam03529   1 SPASISPLPDPLAPSSAScmqrSVSSTASASYPMSYGQASAYSQGYPAGSSSY--FGGVDcgSYLSPMHSQLHHPhQLSP 78

                          90
                  ....*....|...
gi 164519071  261 LSGPSVGPSLAQS 273
Cdd:pfam03529  79 MTASSMGGHLHQH 91
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
64-117 1.58e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 1.58e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 164519071   64 RRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAK 117
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 63-118 3.39e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.39  E-value: 3.39e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 164519071    63 QRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKC 118
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 64-118 9.84e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 89.22  E-value: 9.84e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 164519071  64 RRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKC 118
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKL 55
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
61-117 3.49e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.22  E-value: 3.49e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 164519071  61 RKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAK 117
Cdd:COG5576   49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105
TF_Otx pfam03529
Otx1 transcription factor;
188-273 1.88e-11

Otx1 transcription factor;


Pssm-ID: 427350  Cd Length: 91  Bit Score: 59.54  E-value: 1.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164519071  188 SPASEAPLPEAQRAGLVA----SGPSLTSAPYAMTYAPASAFCSSPSAYASPSsyFSGLD--PYLSPMVPQLGGP-ALSP 260
Cdd:pfam03529   1 SPASISPLPDPLAPSSAScmqrSVSSTASASYPMSYGQASAYSQGYPAGSSSY--FGGVDcgSYLSPMHSQLHHPhQLSP 78

                          90
                  ....*....|...
gi 164519071  261 LSGPSVGPSLAQS 273
Cdd:pfam03529  79 MTASSMGGHLHQH 91
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
64-117 1.58e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 1.58e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 164519071   64 RRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAK 117
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 63-118 3.39e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.39  E-value: 3.39e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 164519071    63 QRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKC 118
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 64-118 9.84e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 89.22  E-value: 9.84e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 164519071  64 RRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKC 118
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKL 55
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
61-117 3.49e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.22  E-value: 3.49e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 164519071  61 RKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAK 117
Cdd:COG5576   49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105
TF_Otx pfam03529
Otx1 transcription factor;
188-273 1.88e-11

Otx1 transcription factor;


Pssm-ID: 427350  Cd Length: 91  Bit Score: 59.54  E-value: 1.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164519071  188 SPASEAPLPEAQRAGLVA----SGPSLTSAPYAMTYAPASAFCSSPSAYASPSsyFSGLD--PYLSPMVPQLGGP-ALSP 260
Cdd:pfam03529   1 SPASISPLPDPLAPSSAScmqrSVSSTASASYPMSYGQASAYSQGYPAGSSSY--FGGVDcgSYLSPMHSQLHHPhQLSP 78

                          90
                  ....*....|...
gi 164519071  261 LSGPSVGPSLAQS 273
Cdd:pfam03529  79 MTASSMGGHLHQH 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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