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Conserved domains on  [gi|165905635|ref|NP_001107026|]
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nudC domain-containing protein 1 isoform 2 [Mus musculus]

Protein Classification

alpha-crystallin domain-containing protein( domain architecture ID 129)

alpha-crystallin domain-containing protein similar to alpha-crystallin-type small heat shock proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
alpha-crystallin-Hsps_p23-like super family cl00175
alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a ...
 276-359 1.11e-41

alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.; The alpha-crystallin-Hsps_p23-like superfamily includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12-43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this superfamily is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).


The actual alignment was detected with superfamily member cd06493:

Pssm-ID: 469641  Cd Length: 85  Bit Score: 144.97  E-value: 1.11e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165905635 276 YYWQQSEDDLTVTVRLPESSTKEDIQIQFLPDNINIKLKDIQ-VLEGKLYSSIDHEGSTWTIKENDSLEISLIKKNEGLM 354
Cdd:cd06493    1 YYWQQTEEDLTLTIRLPEDTTKEDIRIKFLPDHISIALKDQApLLEGKLYSSIDHESSTWIIKENKSLEVSLIKKDEGPT 80


                 ....*
gi 165905635 355 WPELV 359
Cdd:cd06493   81 WPELV 85
 
Name Accession Description Interval E-value
p23_NUDCD1_like cd06493
p23_NUDCD1: p23-like NUD (nuclear distribution) C-like domain found in human NUD (nuclear ...
 276-359 1.11e-41

p23_NUDCD1: p23-like NUD (nuclear distribution) C-like domain found in human NUD (nuclear distribution) C domain-containing protein 1, NUDCD1 (also known as CML66), and similar proteins. NUDCD1/CML66 is a broadly immunogenic tumor associated antigen, which is highly expressed in a variety of solid tumors and in leukemias. In normal tissues high expression of NUDCD1/CML66 is limited to testis and heart.


Pssm-ID: 107242  Cd Length: 85  Bit Score: 144.97  E-value: 1.11e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165905635 276 YYWQQSEDDLTVTVRLPESSTKEDIQIQFLPDNINIKLKDIQ-VLEGKLYSSIDHEGSTWTIKENDSLEISLIKKNEGLM 354
Cdd:cd06493    1 YYWQQTEEDLTLTIRLPEDTTKEDIRIKFLPDHISIALKDQApLLEGKLYSSIDHESSTWIIKENKSLEVSLIKKDEGPT 80


                 ....*
gi 165905635 355 WPELV 359
Cdd:cd06493   81 WPELV 85
CS pfam04969
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ...
 274-348 3.86e-17

CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2.


Pssm-ID: 461503  Cd Length: 76  Bit Score: 76.14  E-value: 3.86e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 165905635  274 PLYYWQQSEDDLTVTVRLPESSTK-EDIQIQFLPDNINIKLKD-IQVLEGKLYSSIDHEGSTWTIkENDSLEISLIK 348
Cdd:pfam04969   1 PRYDWYQTLDEVTITIPVKGAGIKkKDVKVNIKPRSLKVKIKGgYELIDGELFHPIDPEESSWTI-EGKKVEITLKK 76
 
Name Accession Description Interval E-value
p23_NUDCD1_like cd06493
p23_NUDCD1: p23-like NUD (nuclear distribution) C-like domain found in human NUD (nuclear ...
 276-359 1.11e-41

p23_NUDCD1: p23-like NUD (nuclear distribution) C-like domain found in human NUD (nuclear distribution) C domain-containing protein 1, NUDCD1 (also known as CML66), and similar proteins. NUDCD1/CML66 is a broadly immunogenic tumor associated antigen, which is highly expressed in a variety of solid tumors and in leukemias. In normal tissues high expression of NUDCD1/CML66 is limited to testis and heart.


Pssm-ID: 107242  Cd Length: 85  Bit Score: 144.97  E-value: 1.11e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165905635 276 YYWQQSEDDLTVTVRLPESSTKEDIQIQFLPDNINIKLKDIQ-VLEGKLYSSIDHEGSTWTIKENDSLEISLIKKNEGLM 354
Cdd:cd06493    1 YYWQQTEEDLTLTIRLPEDTTKEDIRIKFLPDHISIALKDQApLLEGKLYSSIDHESSTWIIKENKSLEVSLIKKDEGPT 80


                 ....*
gi 165905635 355 WPELV 359
Cdd:cd06493   81 WPELV 85
p23_NUDC_like cd06467
p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) ...
 276-359 1.94e-27

p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) NUDC is needed for nuclear movement. AnNUDC is localized at the hyphal cortex, and binds NUDF at spindle pole bodies (SPBs) and in the cytoplasm at different stages in the cell cycle. At the SPBs it is part of the dynein molecular motor/NUDF complex that regulates microtubule dynamics. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation. This group also includes the human broadly immunogenic tumor associated antigen, CML66, which is highly expressed in a variety of solid tumors and in leukemias. In normal tissues high expression of CML66 is limited to testis and heart.


Pssm-ID: 107224  Cd Length: 85  Bit Score: 105.71  E-value: 1.94e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165905635 276 YYWQQSEDDLTVTVRLPESSTKEDIQIQFLPDNINIKLK-DIQVLEGKLYSSIDHEGSTWTIKENDSLEISLIKKNEGLM 354
Cdd:cd06467    1 YSWTQTLDEVTVTIPLPEGTKSKDVKVEITPKHLKVGVKgGEPLLDGELYAKVKVDESTWTLEDGKLLEITLEKRNEGEW 80


                 ....*
gi 165905635 355 WPELV 359
Cdd:cd06467   81 WPSLV 85
p23_like cd06463
Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) ...
 278-359 3.76e-19

Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis. Both p23 and Sba1p can regulate telomerase activity. This group includes domains similar to the C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1). Sgt1 interacts with multiple protein complexes and has the features of a co-chaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. This group also includes the p23_like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). hB-ind1 plays a role in the signaling pathway mediated by the small GTPase Rac1, NUDC is needed for nuclear movement, Melusin interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


Pssm-ID: 107220  Cd Length: 84  Bit Score: 81.95  E-value: 3.76e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165905635 278 WQQSEDDLTVTVRLPESsTKEDIQIQFLPDNINIKLKDIQ----VLEGKLYSSIDHEGSTWTIKENdSLEISLIKKNEGL 353
Cdd:cd06463    1 WYQTLDEVTITIPLKDV-TKKDVKVEFTPKSLTVSVKGGGgkeyLLEGELFGPIDPEESKWTVEDR-KIEITLKKKEPGE 78


                 ....*.
gi 165905635 354 MWPELV 359
Cdd:cd06463   79 WWPRLE 84
CS pfam04969
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ...
 274-348 3.86e-17

CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2.


Pssm-ID: 461503  Cd Length: 76  Bit Score: 76.14  E-value: 3.86e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 165905635  274 PLYYWQQSEDDLTVTVRLPESSTK-EDIQIQFLPDNINIKLKD-IQVLEGKLYSSIDHEGSTWTIkENDSLEISLIK 348
Cdd:pfam04969   1 PRYDWYQTLDEVTITIPVKGAGIKkKDVKVNIKPRSLKVKIKGgYELIDGELFHPIDPEESSWTI-EGKKVEITLKK 76
p23_NUDCD2_like cd06494
p23-like NUD (nuclear distribution) C-like found in human NUDC domain-containing protein 2 ...
 278-350 1.94e-09

p23-like NUD (nuclear distribution) C-like found in human NUDC domain-containing protein 2 (NUDCD2) and similar proteins. Little is known about the function of the proteins in this subgroup.


Pssm-ID: 107243  Cd Length: 93  Bit Score: 54.77  E-value: 1.94e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 165905635 278 WQQSEDDLTVTVRLPESSTKEDIQIQFLPDNINIKLKDIQVLEGKLYSSIDHEGSTWTIKENDSLEISLIKKN 350
Cdd:cd06494   10 WYQTMDEVFIEVNVPPGTRAKDVKCKLGSRDISLAVKGQEVLKGKLFDSVVADECTWTLEDRKLIRIVLTKSN 82
ACD_sHsps_p23-like cd00298
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small ...
 278-348 3.09e-08

This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this family is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).


Pssm-ID: 107219  Cd Length: 80  Bit Score: 51.05  E-value: 3.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165905635 278 WQQSEDDLTVTVRLPESsTKEDIQIQFLPDNINIKLKDIQ-----------VLEGKLYSSIDHEGSTWTIkENDSLEISL 346
Cdd:cd00298    1 WYQTDDEVVVTVDLPGV-KKEDIKVEVEDNVLTISGKREEeeerersygefERSFELPEDVDPEKSKASL-ENGVLEITL 78


                 ..
gi 165905635 347 IK 348
Cdd:cd00298   79 PK 80
p23_CacyBP cd06468
p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP) ...
 276-352 8.55e-06

p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter two are components of the ubiquitin ligase that regulates beta-catenin degradation. The beta-catenin gene is an oncogene participating in tumorigenesis in many different cancers. Overexpression of CacyBP/SIP, in part through its effect on the expression of beta-catenin, inhibits the proliferation, tumorigenicity, and invasion of gastric cancer cells. CacyBP/SIP is abundant in neurons and neuroblastoma NB2a cells. An extensive re-organization of microtubules accompanies the differentiation of NB2a cells. CacyBP/SIP may contribute to NB2a cell differentiation through binding to and increasing the oligomerization of tubulin. CacyBP/SIP is also implicated in differentiation of erythroid cells, rat neonatal cardiomyocytes, in mouse endometrial events, and in thymocyte development.


Pssm-ID: 107225  Cd Length: 92  Bit Score: 44.56  E-value: 8.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165905635 276 YYWQQSEDDLTVTVRLPESST--KEDIQIQFLPDNINIKLKDiqvLEGK--------LYSSIDHEGSTWTIKEnDSLEIS 345
Cdd:cd06468    4 YAWDQSDKFVKIYITLKGVHQlpKENIQVEFTERSFELKVHD---LNGKnyrftinrLLKKIDPEKSSFKVKT-DRIVIT 79


                 ....*..
gi 165905635 346 LIKKNEG 352
Cdd:cd06468   80 LAKKKEK 86
p23_CS_SGT1_like cd06466
p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 ...
 278-358 9.45e-05

p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. ScSgt1 is needed for the G1/S and G2/M cell-cycle transitions, and for assembly of the core kinetochore complex (CBF3) via activation of Ctf13, the F-box protein. Binding of Hsp82 (a yeast Hsp90 homologue) to ScSgt1, promotes the binding of Sgt1 to Skp1 and of Skp1 to Ctf13. Some proteins in this group have an SGT1-specific (SGS) domain at the extreme C-terminus. The ScSgt1-SGS domain binds adenylate cyclase. The hSgt1-SGS domain interacts with some S100 family proteins, and studies suggest that the interaction of hSgt1 with Hsp90 and Hsp70 may be regulated by S100A6 in a Ca2+ dependent fashion. This group also includes the p23_like domains of Melusin and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). Melusin is a vertebrate protein which interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


Pssm-ID: 107223  Cd Length: 84  Bit Score: 41.03  E-value: 9.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165905635 278 WQQSEDDLTVTVrLPESSTKEDIQIQFLPDNINIKLK----DIQVLEGKLYSSIDHEGSTWTIKENdSLEISLIKKnEGL 353
Cdd:cd06466    2 WYQTDTSVTVTI-YAKNVDKEDVKVEFNEQSLSVSIIlpggSEYQLELDLFGPIDPEQSKVSVLPT-KVEITLKKA-EPG 78


                 ....*
gi 165905635 354 MWPEL 358
Cdd:cd06466   79 SWPSL 83
p23_mNUDC_like cd06492
p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. ...
 276-359 4.12e-04

p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation.


Pssm-ID: 107241  Cd Length: 87  Bit Score: 39.63  E-value: 4.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165905635 276 YYWQQ--SEDDLTVTVRLPESSTKEDIQIQFLPDNINIKLKDIQ-VLEGKLYSSIDHEGSTWTIKENDSLEISLIKKNEG 352
Cdd:cd06492    1 YRWTQtlSEVELKVPFKVSFRLKGKDVVVDIQRKHLKVGLKGQPpIIDGELYNEVKVEESSWLIEDGKVVTVNLEKINKM 80


                 ....*..
gi 165905635 353 LMWPELV 359
Cdd:cd06492   81 EWWSRLV 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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