cellular tumor antigen p53 isoform d [Homo sapiens]
P53 and P53_tetramer domain-containing protein( domain architecture ID 10170140)
P53 and P53_tetramer domain-containing protein
List of domain hits
Name | Accession | Description | Interval | E-value | |||
P53 | cd08367 | P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ... |
1-156 | 3.91e-82 | |||
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes. : Pssm-ID: 176262 Cd Length: 179 Bit Score: 244.10 E-value: 3.91e-82
|
|||||||
P53_tetramer | pfam07710 | P53 tetramerization motif; |
187-226 | 2.32e-14 | |||
P53 tetramerization motif; : Pssm-ID: 462238 Cd Length: 42 Bit Score: 65.38 E-value: 2.32e-14
|
|||||||
Name | Accession | Description | Interval | E-value | |||
P53 | cd08367 | P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ... |
1-156 | 3.91e-82 | |||
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes. Pssm-ID: 176262 Cd Length: 179 Bit Score: 244.10 E-value: 3.91e-82
|
|||||||
P53 | pfam00870 | P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ... |
1-157 | 4.52e-71 | |||
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort. Pssm-ID: 459972 [Multi-domain] Cd Length: 191 Bit Score: 216.38 E-value: 4.52e-71
|
|||||||
P53_tetramer | pfam07710 | P53 tetramerization motif; |
187-226 | 2.32e-14 | |||
P53 tetramerization motif; Pssm-ID: 462238 Cd Length: 42 Bit Score: 65.38 E-value: 2.32e-14
|
|||||||
Name | Accession | Description | Interval | E-value | |||
P53 | cd08367 | P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ... |
1-156 | 3.91e-82 | |||
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes. Pssm-ID: 176262 Cd Length: 179 Bit Score: 244.10 E-value: 3.91e-82
|
|||||||
P53 | pfam00870 | P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ... |
1-157 | 4.52e-71 | |||
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort. Pssm-ID: 459972 [Multi-domain] Cd Length: 191 Bit Score: 216.38 E-value: 4.52e-71
|
|||||||
P53_tetramer | pfam07710 | P53 tetramerization motif; |
187-226 | 2.32e-14 | |||
P53 tetramerization motif; Pssm-ID: 462238 Cd Length: 42 Bit Score: 65.38 E-value: 2.32e-14
|
|||||||
Blast search parameters | ||||
|