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Conserved domains on  [gi|187283062|ref|NP_001119792|]
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keratin associated protein 4-like [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 38-167 9.30e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.89  E-value: 9.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187283062   38 SCCVSSCCRPQCCQSVCCQPTCCRPSCCRPSCCVSSCCRPSC---CQSVCCQPTCCRPSCCRPSCCISSCCQPSCGSSSC 114
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVS 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 187283062  115 CG-------SSCCRPCCRPCCRPCCCLRPVCGQVCCQTTCYRPTCVISTCPRPMCCATPC 167
Cdd:pfam01500  98 SRtrwcrpdCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
3-58 2.87e-03

Keratin, high sulfur B2 protein;


:

Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 34.28  E-value: 2.87e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 187283062    3 SSCCGSVCseegCGQGCCQPSCCqttccrttccRPSCCVSSCCRPQCCQSVCCQPT 58
Cdd:pfam13885   4 PSCCQPSC----CQPSCCQPSCC----------QPSCCQPSCCRPSCCRSSCCQPT 45
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 38-167 9.30e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.89  E-value: 9.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187283062   38 SCCVSSCCRPQCCQSVCCQPTCCRPSCCRPSCCVSSCCRPSC---CQSVCCQPTCCRPSCCRPSCCISSCCQPSCGSSSC 114
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVS 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 187283062  115 CG-------SSCCRPCCRPCCRPCCCLRPVCGQVCCQTTCYRPTCVISTCPRPMCCATPC 167
Cdd:pfam01500  98 SRtrwcrpdCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
39-92 1.39e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 41.07  E-value: 1.39e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 187283062  39 CCVSSCCRPQCCQSVCCQPTCCRPSCCRPSCCVssCCRpsCCQSVCCQPTCCRP 92
Cdd:COG3901  635 CCGCCCCCCKCCCIVIIIDGIIIINECCCCCCL--CCR--RCQDDPLCPPRIKK 684
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
3-58 2.87e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 34.28  E-value: 2.87e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 187283062    3 SSCCGSVCseegCGQGCCQPSCCqttccrttccRPSCCVSSCCRPQCCQSVCCQPT 58
Cdd:pfam13885   4 PSCCQPSC----CQPSCCQPSCC----------QPSCCQPSCCRPSCCRSSCCQPT 45
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 38-167 9.30e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.89  E-value: 9.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187283062   38 SCCVSSCCRPQCCQSVCCQPTCCRPSCCRPSCCVSSCCRPSC---CQSVCCQPTCCRPSCCRPSCCISSCCQPSCGSSSC 114
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVS 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 187283062  115 CG-------SSCCRPCCRPCCRPCCCLRPVCGQVCCQTTCYRPTCVISTCPRPMCCATPC 167
Cdd:pfam01500  98 SRtrwcrpdCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
54-98 1.78e-14

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 63.94  E-value: 1.78e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 187283062   54 CCQPTCCRPSCCRPSCCVSSCCRPSCCQSVCCQPTCCRPSCCRPS 98
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
44-88 1.92e-14

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 63.56  E-value: 1.92e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 187283062   44 CCRPQCCQSVCCQPTCCRPSCCRPSCCVSSCCRPSCCQSVCCQPT 88
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
49-93 2.38e-14

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 63.56  E-value: 2.38e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 187283062   49 CCQSVCCQPTCCRPSCCRPSCCVSSCCRPSCCQSVCCQPTCCRPS 93
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
39-83 1.66e-12

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 58.55  E-value: 1.66e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 187283062   39 CCVSSCCRPQCCQSVCCQPTCCRPSCCRPSCCVSSCCRPSCCQSV 83
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
37-78 7.36e-12

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 57.01  E-value: 7.36e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 187283062   37 PSCCVSSCCRPQCCQSVCCQPTCCRPSCCRPSCCVSSCCRPS 78
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
64-101 8.84e-11

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 54.31  E-value: 8.84e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 187283062   64 CCRPSCCVSSCCRPSCCQSVCCQPTCCRPSCCRPSCCI 101
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCR 38
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 37-168 3.39e-10

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 55.57  E-value: 3.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187283062   37 PSCCVSSCCRPQCCQSvCC------QPTCCRPSCCRPSCCVSSCCRPSC---CQSVCCQPTCCRPSCCRPSCCISSCCQP 107
Cdd:pfam01500  12 PTCSTGGTCGSGCCQP-CCcqssccRPSCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQE 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187283062  108 SCGSSSCCGSSCCRPCCRPCCRPCCCLRPVCgqvCCQTTCYRPTCVISTCPRPMCCATPCC 168
Cdd:pfam01500  91 GSSGAVSSRTRWCRPDCRVEGTCLPPCCVVS---CTPPTCCQLHHAQASCCRPSYCGQSCC 148
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
19-68 4.67e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 44.30  E-value: 4.67e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 187283062   19 CCQPSCCQTTCCRttccrPSCCVSSCCRPQCCQSVCCQPTCCRPSCCRPS 68
Cdd:pfam13885   1 CCQPSCCQPSCCQ-----PSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
39-92 1.39e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 41.07  E-value: 1.39e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 187283062  39 CCVSSCCRPQCCQSVCCQPTCCRPSCCRPSCCVssCCRpsCCQSVCCQPTCCRP 92
Cdd:COG3901  635 CCGCCCCCCKCCCIVIIIDGIIIINECCCCCCL--CCR--RCQDDPLCPPRIKK 684
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
44-101 1.42e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 41.07  E-value: 1.42e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 187283062  44 CCRPQCCqsvCCQPTCCRPSCCRPSCCVSSCCR-PSCCQSVCCQPTCCRPSCCRPSCCI 101
Cdd:COG3901  628 RRRRREC---CCGCCCCCCKCCCIVIIIDGIIIiNECCCCCCLCCRRCQDDPLCPPRIK 683
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
39-100 2.06e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 40.69  E-value: 2.06e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 187283062  39 CCVSSCCRPQCCQSVCCQPTCCRPSCCRPSCCVSSCCRPSCCQSVCCQPTCCRPSCCRPSCC 100
Cdd:COG3901  605 FFRRLCLLGLALAAAALARRRLWRRRRRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCCC 666
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 59-168 2.61e-04

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 39.39  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187283062   59 CCRPSCCRPSCCVSSCCRPSCCQSVCCQPTCCRPSCCRPSCCISSCCQPSCGSSSCCGSSCCRPCCRPCCRPCCCLRPVC 138
Cdd:pfam01500   4 CGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCG 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 187283062  139 ----------GQVCCQTTCYRPTCVISTCPRPMCCATPCC 168
Cdd:pfam01500  84 gigygqegssGAVSSRTRWCRPDCRVEGTCLPPCCVVSCT 123
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
74-160 7.82e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.82  E-value: 7.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187283062   74 CCRPSCCQSVCCQPTCCRPSCCRPSCCissccqpscgsssccgssccrpccrpccrpccclrpvcgqvccQTTCYRPTCV 153
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCC-------------------------------------------QPSCCRPSCC 37


                  ....*..
gi 187283062  154 ISTCPRP 160
Cdd:pfam13885  38 RSSCCQP 44
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
3-58 2.87e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 34.28  E-value: 2.87e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 187283062    3 SSCCGSVCseegCGQGCCQPSCCqttccrttccRPSCCVSSCCRPQCCQSVCCQPT 58
Cdd:pfam13885   4 PSCCQPSC----CQPSCCQPSCC----------QPSCCQPSCCRPSCCRSSCCQPT 45
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
18-97 2.93e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 37.22  E-value: 2.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187283062  18 GCCQPSCCQTTCCRTTCCRPSCCVSSCCRPQCCqsVCCQptCCRPSCCRPSCCvssCCRPSCCQSVCCQPTCCRPSCCRP 97
Cdd:COG3901  612 LGLALAAAALARRRLWRRRRRECCCGCCCCCCK--CCCI--VIIIDGIIIINE---CCCCCCLCCRRCQDDPLCPPRIKK 684
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 64-168 5.38e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 35.54  E-value: 5.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187283062   64 CCRPSCCVSSCCRPSCCQSVCCQPTCCRPSCCRPSCCISSCCQPSCGSSSCCGSSCCRPCCRPCCRPCCCLRPVCGQVC- 142
Cdd:pfam01500   4 CGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCg 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 187283062  143 -------------------CQTTCYRPTCVISTCPRPMCCATPCC 168
Cdd:pfam01500  84 gigygqegssgavssrtrwCRPDCRVEGTCLPPCCVVSCTPPTCC 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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