NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|187829742|ref|NP_001120713|]
View 

bcl-2-binding component 3 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PUMA super family cl25492
Bcl-2-binding component 3, p53 upregulated modulator of apoptosis; PUMA (p53 upregulated ...
 25-131 3.95e-42

Bcl-2-binding component 3, p53 upregulated modulator of apoptosis; PUMA (p53 upregulated modulator of apoptosis) is a family of eukaryotic proteins that are a target for activation by p53. The proteins contain BH3 domains and are induced in cells after p53 activation. They bind to Bcl-2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of apoptosis.


The actual alignment was detected with superfamily member pfam15826:

Pssm-ID: 374148 [Multi-domain]  Cd Length: 189  Bit Score: 137.39  E-value: 3.95e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829742   25 PCQICGPQPSLSLAEQHLESPVpsapgalAGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNAQYERRR-QEEQQRHRP 103
Cdd:pfam15826  89 PRPLAGPQPSLSPAEPHLESPV-------AGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNALYERRRrQEEQQRHRP 161

                          90       100
                  ....*....|....*....|....*...
gi 187829742  104 SPWRVLYNLIMGLLPLPRGHRAPEMEPN 131
Cdd:pfam15826 162 SPWRVLYNLIMGLLPLPRGHRAPEMEPN 189
 
Name Accession Description Interval E-value
PUMA pfam15826
Bcl-2-binding component 3, p53 upregulated modulator of apoptosis; PUMA (p53 upregulated ...
 25-131 3.95e-42

Bcl-2-binding component 3, p53 upregulated modulator of apoptosis; PUMA (p53 upregulated modulator of apoptosis) is a family of eukaryotic proteins that are a target for activation by p53. The proteins contain BH3 domains and are induced in cells after p53 activation. They bind to Bcl-2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of apoptosis.


Pssm-ID: 374148 [Multi-domain]  Cd Length: 189  Bit Score: 137.39  E-value: 3.95e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829742   25 PCQICGPQPSLSLAEQHLESPVpsapgalAGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNAQYERRR-QEEQQRHRP 103
Cdd:pfam15826  89 PRPLAGPQPSLSPAEPHLESPV-------AGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNALYERRRrQEEQQRHRP 161

                          90       100
                  ....*....|....*....|....*...
gi 187829742  104 SPWRVLYNLIMGLLPLPRGHRAPEMEPN 131
Cdd:pfam15826 162 SPWRVLYNLIMGLLPLPRGHRAPEMEPN 189
 
Name Accession Description Interval E-value
PUMA pfam15826
Bcl-2-binding component 3, p53 upregulated modulator of apoptosis; PUMA (p53 upregulated ...
 25-131 3.95e-42

Bcl-2-binding component 3, p53 upregulated modulator of apoptosis; PUMA (p53 upregulated modulator of apoptosis) is a family of eukaryotic proteins that are a target for activation by p53. The proteins contain BH3 domains and are induced in cells after p53 activation. They bind to Bcl-2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of apoptosis.


Pssm-ID: 374148 [Multi-domain]  Cd Length: 189  Bit Score: 137.39  E-value: 3.95e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829742   25 PCQICGPQPSLSLAEQHLESPVpsapgalAGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNAQYERRR-QEEQQRHRP 103
Cdd:pfam15826  89 PRPLAGPQPSLSPAEPHLESPV-------AGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNALYERRRrQEEQQRHRP 161

                          90       100
                  ....*....|....*....|....*...
gi 187829742  104 SPWRVLYNLIMGLLPLPRGHRAPEMEPN 131
Cdd:pfam15826 162 SPWRVLYNLIMGLLPLPRGHRAPEMEPN 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH