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Conserved domains on  [gi|196115141|ref|NP_001124487|]
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cip1-interacting zinc finger protein isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 117-426 5.33e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 5.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  117 ATLGNLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRk 196
Cdd:PHA03247 2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA- 2768

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  197 dsssqtmpvedkSDPPEGSEEAAEPRMDTPEDQDLPPCPEDiAKEKRTPAPEPEPCEAselPAKRLRSSEEPTEKEPPgq 276
Cdd:PHA03247 2769 ------------PAPPAAPAAGPPRRLTRPAVASLSESRES-LPSPWDPADPPAAVLA---PAAALPPAASPAGPLPP-- 2830

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  277 lqvkaQPQARMTVPKQTQTPDLLPEALEAQVLP----RFQPRVLQVQAQVQSQTQPRIPS-TDTQVQPKLQKQAQTQTSP 351
Cdd:PHA03247 2831 -----PTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQP 2905

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 196115141  352 EHLVLQqkqvqpqlqqeaEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVV 426
Cdd:PHA03247 2906 ERPPQP------------QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 630-654 1.41e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 42.54  E-value: 1.41e-05
                          10        20
                  ....*....|....*....|....*
gi 196115141  630 FCTVCNRYFKTPRKFVEHVKSQGHK 654
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 536-565 4.83e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.39  E-value: 4.83e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 196115141   536 QFFCYICKASCSSQQEFQDHMSEPQHQQRL 565
Cdd:smart00451   3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
UFD2 super family cl40793
U1-like Zn-finger-containing protein [General function prediction only];
610-661 4.69e-03

U1-like Zn-finger-containing protein [General function prediction only];


The actual alignment was detected with superfamily member COG5112:

Pssm-ID: 227443  Cd Length: 126  Bit Score: 38.14  E-value: 4.69e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141 610 DLIQHRRTQDHKIAKQSLRP--------FCTVCNRYFKTPRKFVEHVKSQGHKDKAKELK 661
Cdd:COG5112   29 DQIKNDLSTKESQKKLPYDPelpglgqhYCIECARYFITEKALMEHKKGKVHKRRAKELR 88
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 117-426 5.33e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 5.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  117 ATLGNLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRk 196
Cdd:PHA03247 2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA- 2768

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  197 dsssqtmpvedkSDPPEGSEEAAEPRMDTPEDQDLPPCPEDiAKEKRTPAPEPEPCEAselPAKRLRSSEEPTEKEPPgq 276
Cdd:PHA03247 2769 ------------PAPPAAPAAGPPRRLTRPAVASLSESRES-LPSPWDPADPPAAVLA---PAAALPPAASPAGPLPP-- 2830

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  277 lqvkaQPQARMTVPKQTQTPDLLPEALEAQVLP----RFQPRVLQVQAQVQSQTQPRIPS-TDTQVQPKLQKQAQTQTSP 351
Cdd:PHA03247 2831 -----PTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQP 2905

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 196115141  352 EHLVLQqkqvqpqlqqeaEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVV 426
Cdd:PHA03247 2906 ERPPQP------------QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 630-654 1.41e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 42.54  E-value: 1.41e-05
                          10        20
                  ....*....|....*....|....*
gi 196115141  630 FCTVCNRYFKTPRKFVEHVKSQGHK 654
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 232-444 3.97e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.34  E-value: 3.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  232 PPCPEDIAKEKRTPAPEPE---PCEASELPAKRLRSSEEP-TEKEPPGQLQVKA--------QPQARMTVPKQTQTPDLL 299
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQyqyASQQSQQPSKPVRTGYEKyKEPEPIPDLQVDAslwgvapkKAAAPAPAPQPAAQPASL 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  300 P---------EALEAQVlpRFQPRVLQVQAQVQSQTQPripstdtqVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAE 370
Cdd:pfam09770 187 PapsrkmmslEEVEAAM--RAQAKKPAQQPAPAPAQPP--------AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQH 256

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 196115141  371 PQKQVQPQVHtQAQPSVQPqehPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVVVHVCGLEMPPDAVEAGGG 444
Cdd:pfam09770 257 PGQGHPVTIL-QRPQSPQP---DPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQP 326
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 536-565 4.83e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.39  E-value: 4.83e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 196115141   536 QFFCYICKASCSSQQEFQDHMSEPQHQQRL 565
Cdd:smart00451   3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
UFD2 COG5112
U1-like Zn-finger-containing protein [General function prediction only];
610-661 4.69e-03

U1-like Zn-finger-containing protein [General function prediction only];


Pssm-ID: 227443  Cd Length: 126  Bit Score: 38.14  E-value: 4.69e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141 610 DLIQHRRTQDHKIAKQSLRP--------FCTVCNRYFKTPRKFVEHVKSQGHKDKAKELK 661
Cdd:COG5112   29 DQIKNDLSTKESQKKLPYDPelpglgqhYCIECARYFITEKALMEHKKGKVHKRRAKELR 88
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 117-426 5.33e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 5.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  117 ATLGNLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRk 196
Cdd:PHA03247 2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA- 2768

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  197 dsssqtmpvedkSDPPEGSEEAAEPRMDTPEDQDLPPCPEDiAKEKRTPAPEPEPCEAselPAKRLRSSEEPTEKEPPgq 276
Cdd:PHA03247 2769 ------------PAPPAAPAAGPPRRLTRPAVASLSESRES-LPSPWDPADPPAAVLA---PAAALPPAASPAGPLPP-- 2830

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  277 lqvkaQPQARMTVPKQTQTPDLLPEALEAQVLP----RFQPRVLQVQAQVQSQTQPRIPS-TDTQVQPKLQKQAQTQTSP 351
Cdd:PHA03247 2831 -----PTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQP 2905

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 196115141  352 EHLVLQqkqvqpqlqqeaEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVV 426
Cdd:PHA03247 2906 ERPPQP------------QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
PHA03247 PHA03247
large tegument protein UL36; Provisional
 128-424 2.73e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 2.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  128 ASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGvPMNPSQFNLSGRnPQKQARTSSSTTPnrkdSSSQTMPVED 207
Cdd:PHA03247 2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG-PATPGGPARPAR-PPTTAGPPAPAPP----AAPAAGPPRR 2782

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  208 KSDPPEGSEEAAEPRMDTPEDQDLPPCPEDIAKEKRTPAPEP---EPCEASELPAKRLRSSEEPTEKEPPGQLQVKAQPQ 284
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPagpLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDV 2862

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  285 ARMTVPKQTQTPDLLPEALEAQVLPRFQ-PRVLQVQAQVQSQtQPRIPSTDTQVQPKLQKQAQTQTSPEhlvlqqkqvqP 363
Cdd:PHA03247 2863 RRRPPSRSPAAKPAAPARPPVRRLARPAvSRSTESFALPPDQ-PERPPQPQAPPPPQPQPQPPPPPQPQ----------P 2931

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 196115141  364 QLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHT-QPQVSLLAPEQTP 424
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVpQPAPSREAPASST 2993
PHA03247 PHA03247
large tegument protein UL36; Provisional
 129-442 2.89e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 2.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  129 SPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSG----------RNPQKQARTSSSTT-PNRKD 197
Cdd:PHA03247 2608 PRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPApgrvsrprraRRLGRAAQASSPPQrPRRRA 2687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  198 SSSQTMPVEDKSDPPEGSEEAAEPRMDTPEDQDLPPCPEDIAKEK----RTPAPEPEPcEASELPAKRLRSSEEPTEKEP 273
Cdd:PHA03247 2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASpalpAAPAPPAVP-AGPATPGGPARPARPPTTAGP 2766

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  274 PGqlqvKAQPQARMTVPKQTQT-PDLLPEALEAQVLPrfQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPE 352
Cdd:PHA03247 2767 PA----PAPPAAPAAGPPRRLTrPAVASLSESRESLP--SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  353 HLVLQQKQVQP----------------QLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQ--VSVQPPEQTHEQPHTQPQ 414
Cdd:PHA03247 2841 PPPGPPPPSLPlggsvapggdvrrrppSRSPAAKPAAPARPPVRRLARPAVSRSTESFALppDQPERPPQPQAPPPPQPQ 2920

                         330       340
                  ....*....|....*....|....*...
gi 196115141  415 VSLLAPEQTPVVVHVCGLEMPPDAVEAG 442
Cdd:PHA03247 2921 PQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 630-654 1.41e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 42.54  E-value: 1.41e-05
                          10        20
                  ....*....|....*....|....*
gi 196115141  630 FCTVCNRYFKTPRKFVEHVKSQGHK 654
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 128-420 3.93e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.39  E-value: 3.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  128 ASPGLAAPSLTPPQLATPNLQ---QFFPQATRqsllgPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRKDSSSQTMP 204
Cdd:PRK10263  577 AAATVAAPVFSLANSGGPRPQvkeGIGPQLPR-----PKRIRVPTRRELASYGIKLPSQRAAEEKAREAQRNQYDSGDQY 651

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  205 VEDKSDPPEGSEEAAE------PRMDTPEDQDLPPCPEDiakekRTPAPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQ 278
Cdd:PRK10263  652 NDDEIDAMQQDELARQfaqtqqQRYGEQYQHDVPVNAED-----ADAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDD 726

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  279 VKAQPQArmtvpkqtqtpDLLPEALEAqvlPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTS--PEHLVL 356
Cdd:PRK10263  727 FEFSPMK-----------ALLDDGPHE---PLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPvaPQPQYQ 792

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 196115141  357 QQKQVQPQLQQEAEPQKQVQPQVHTQaqpsvQPQEhppaQVSVQPPEQTHEQPHT-QPQVSLLAP 420
Cdd:PRK10263  793 QPQQPVAPQPQYQQPQQPVAPQPQYQ-----QPQQ----PVAPQPQYQQPQQPVApQPQDTLLHP 848
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 232-444 3.97e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.34  E-value: 3.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  232 PPCPEDIAKEKRTPAPEPE---PCEASELPAKRLRSSEEP-TEKEPPGQLQVKA--------QPQARMTVPKQTQTPDLL 299
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQyqyASQQSQQPSKPVRTGYEKyKEPEPIPDLQVDAslwgvapkKAAAPAPAPQPAAQPASL 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  300 P---------EALEAQVlpRFQPRVLQVQAQVQSQTQPripstdtqVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAE 370
Cdd:pfam09770 187 PapsrkmmslEEVEAAM--RAQAKKPAQQPAPAPAQPP--------AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQH 256

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 196115141  371 PQKQVQPQVHtQAQPSVQPqehPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVVVHVCGLEMPPDAVEAGGG 444
Cdd:pfam09770 257 PGQGHPVTIL-QRPQSPQP---DPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQP 326
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 182-424 7.24e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 7.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  182 QKQARTSSSTTPNRKDSS-SQTMPVEDKSDPPEGSEEAAEPRmdtPEDQDLPPCPEDIAKEKRTPAPEPEPCEASELPAK 260
Cdd:pfam03154  83 QREKGASDTEEPERATAKkSKTQEISRPNSPSEGEGESSDGR---SVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSD 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  261 RLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQP------------ 328
Cdd:pfam03154 160 SSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhtliqqtptlhp 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  329 -RIPSTDTQVQPKLQKQAQTQTSPEHLVLQQ---KQVQPQLQQEAEP---QKQVQPQVHTQAQPSVQPQEHPPAQVSVqp 401
Cdd:pfam03154 240 qRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgQMPPMPHSLQTGPshmQHPVPPQPFPLTPQSSQSQVPPGPSPAA-- 317

                         250       260
                  ....*....|....*....|...
gi 196115141  402 PEQTHEQPHTQPQVSLLAPEQTP 424
Cdd:pfam03154 318 PGQSQQRIHTPPSQSQLQSQQPP 340
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 268-426 2.63e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.69  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  268 PTEKEPPGQLQVKAQPqarmtVP-KQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQ 346
Cdd:PRK10263  347 ASVDVPPAQPTVAWQP-----VPgPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYY 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  347 TQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVsvqPPEQTHEQPHTQPQVSLLAPEqtPVV 426
Cdd:PRK10263  422 APAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPA---AQEPLYQQPQPVEQQPVVEPE--PVV 496
PHA03247 PHA03247
large tegument protein UL36; Provisional
 139-535 3.79e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  139 PPQLATPNLQqffPQATRQSLlgPPPVGVPmnpsqfnlsgrNPQKQARTSSSTTPNRKDSSSQTMPVEDKSDPPEGSEEA 218
Cdd:PHA03247 2551 PPPPLPPAAP---PAAPDRSV--PPPRPAP-----------RPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPP 2614

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  219 AEPRMDTPEDQDLPPCPEDIAKEKRTPAPEPEPceaselPAKRLRSSEEPTEKEPPGQLQVKAQPqARMTVPKQTQTPDL 298
Cdd:PHA03247 2615 SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVP------PPERPRDDPAPGRVSRPRRARRLGRA-AQASSPPQRPRRRA 2687

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  299 LPEA---LEAQVLPRFQPRvlqvqaQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQV 375
Cdd:PHA03247 2688 ARPTvgsLTSLADPPPPPP------TPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPP 2761

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  376 QPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSllAPEQTPVVVHVCGLEMPPDAVEAGGGMEKTLPEPVGT 455
Cdd:PHA03247 2762 TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPW--DPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  456 QVSMEEIQNESACGLDVGECENRAREMPgvwgaggslkvtilqssdSRAFSTVPLTPvPRPSDSVSSTPAATSTPSKQAL 535
Cdd:PHA03247 2840 PPPPGPPPPSLPLGGSVAPGGDVRRRPP------------------SRSPAAKPAAP-ARPPVRRLARPAVSRSTESFAL 2900
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 536-565 4.83e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.39  E-value: 4.83e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 196115141   536 QFFCYICKASCSSQQEFQDHMSEPQHQQRL 565
Cdd:smart00451   3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
PRK10927 PRK10927
cell division protein FtsN;
258-424 1.36e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 41.59  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141 258 PAKRLRSSEEPTEKEPpgQLQVKAQPQARMTVPKQTQtpdLLPEalEAQVLPRFQPRVLQVQAQVQSQtqPRIPSTDTQV 337
Cdd:PRK10927  79 PEERWRYIKELESRQP--GVRAPTEPSAGGEVKTPEQ---LTPE--QRQLLEQMQADMRQQPTQLVEV--PWNEQTPEQR 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141 338 QPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSL 417
Cdd:PRK10927 150 QQTLQRQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQPYQDLLQTPAHTTAQSKPQQAAPV 229


                 ....*..
gi 196115141 418 LAPEQTP 424
Cdd:PRK10927 230 TRAADAP 236
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
165-350 2.07e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 41.57  E-value: 2.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141 165 VGVPMNPSQFNLSGRNPQKQARTSSSttpnrkdSSSQTMPVEDKSDPP-EGSEEAAEPRMDTPedqdlpPCPEDIAKEKR 243
Cdd:PRK14960 368 VSEPVQQNGQAEVGLNSQAQTAQEIT-------PVSAVQPVEVISQPAmVEPEPEPEPEPEPE------PEPEPEPEPEP 434

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141 244 TPAPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTP-DLLPEALEAQVLPRF--QPRVLQVQA 320
Cdd:PRK14960 435 EPEPEPEPQPNQDLMVFDPNHHELIGLESAVVQETVSVLEEDFIPVPEQKLVQvQAETQVKQIEPEPAStaEPIGLFEAS 514

                        170       180       190
                 ....*....|....*....|....*....|
gi 196115141 321 QVQSQTQPRIPSTDTQVQPKLQKQAQTQTS 350
Cdd:PRK14960 515 SAEFSLAQDTSAYDLVSEPVIEQQSLVQAE 544
rne PRK10811
ribonuclease E; Reviewed
 225-444 2.60e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 41.56  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  225 TPEDQDLPPCPEDIAKEKRTPAPEPEPCEASELPAKRLRSSEEPTEKEPPgqlQVKAQPQARMTVPKQTQTPDLlpeale 304
Cdd:PRK10811  849 RPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEP---VVVAEPQPEEVVVVETTHPEV------ 919

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  305 aqvlprfqprvlqVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVHTQAQ 384
Cdd:PRK10811  920 -------------IAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAE 986

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 196115141  385 PSVQPQEHPPAQVSVQPP---EQTHEQPH-TQPQVSLLAPEQTPVVVHVCGLEMPPDAVEAGGG 444
Cdd:PRK10811  987 VAAEVETVTAVEPEVAPAqvpEATVEHNHaTAPMTRAPAPEYVPEAPRHSDWQRPTFAFEGKGA 1050
PRK10927 PRK10927
cell division protein FtsN;
245-408 2.98e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 40.82  E-value: 2.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141 245 PAPEPEPCEASELPAKR--LRSSEEPT---EKEPPGQL-----QVKAQPQARMTvpkqtQTPDLLPEALEAQVLPRFQPR 314
Cdd:PRK10927  77 PKPEERWRYIKELESRQpgVRAPTEPSaggEVKTPEQLtpeqrQLLEQMQADMR-----QQPTQLVEVPWNEQTPEQRQQ 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141 315 VLQVQAQVQSQTQPRiPSTDTQVQPKLQKQAQTQTSpehlVLQQKQVQPQLQQEAEPQKQ----VQPQVHTQAQPsvQPQ 390
Cdd:PRK10927 152 TLQRQRQAQQLAEQQ-RLAQQSRTTEQSWQQQTRTS----QAAPVQAQPRQSKPASTQQPyqdlLQTPAHTTAQS--KPQ 224

                        170
                 ....*....|....*...
gi 196115141 391 EHPPAQVSVQPPEQTHEQ 408
Cdd:PRK10927 225 QAAPVTRAADAPKPTAEK 242
PRK12757 PRK12757
cell division protein FtsN; Provisional
 320-425 3.77e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 40.03  E-value: 3.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141 320 AQVQSQTQpripSTDTQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVSV 399
Cdd:PRK12757  72 GEVNSPTQ----LTDEQRQLLEQMQADMRQQPTQLSEVPYNEQTPQVPRSTVQIQQQAQQQQPPATTAQPQPVTPPRQTT 147

                         90       100
                 ....*....|....*....|....*.
gi 196115141 400 QPPEQTHEQPHTQPQvslLAPEQTPV 425
Cdd:PRK12757 148 APVQPQTPAPVRTQP---AAPVTQAV 170
UFD2 COG5112
U1-like Zn-finger-containing protein [General function prediction only];
610-661 4.69e-03

U1-like Zn-finger-containing protein [General function prediction only];


Pssm-ID: 227443  Cd Length: 126  Bit Score: 38.14  E-value: 4.69e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141 610 DLIQHRRTQDHKIAKQSLRP--------FCTVCNRYFKTPRKFVEHVKSQGHKDKAKELK 661
Cdd:COG5112   29 DQIKNDLSTKESQKKLPYDPelpglgqhYCIECARYFITEKALMEHKKGKVHKRRAKELR 88
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 182-425 5.16e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 5.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  182 QKQARTSSSTTPNRKDSSSQTMPVEDKSDPPEGSEE--AAEPRMDTPEDQ--DLPPCPEDIAKEKRTPAPEPEPCEASEL 257
Cdd:pfam03154 105 QEISRPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDnrSTSPSIPSPQDNesDSDSSAQQQILQTQPPVLQAQSGAASPP 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  258 PAKRLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQPRIPST---D 334
Cdd:pfam03154 185 SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQvspQ 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  335 TQVQPKLQKQAQT-----QTSPEHLVLQQKQVQPQLQQEAEpQKQVQPQVHTQAQ-PSVQPQEHPPAQVSV---QPPEQT 405
Cdd:pfam03154 265 PLPQPSLHGQMPPmphslQTGPSHMQHPVPPQPFPLTPQSS-QSQVPPGPSPAAPgQSQQRIHTPPSQSQLqsqQPPREQ 343

                         250       260
                  ....*....|....*....|
gi 196115141  406 HEQPHTQPQVSLLAPEQTPV 425
Cdd:pfam03154 344 PLPPAPLSMPHIKPPPTTPI 363
PRK12757 PRK12757
cell division protein FtsN; Provisional
 323-412 6.44e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 39.26  E-value: 6.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141 323 QSQTQPRIPSTDTQVQPKLQKQAQTQTSPehlvlqqkqvqpqlQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPP 402
Cdd:PRK12757 108 NEQTPQVPRSTVQIQQQAQQQQPPATTAQ--------------PQPVTPPRQTTAPVQPQTPAPVRTQPAAPVTQAVEAP 173

                         90
                 ....*....|
gi 196115141 403 EQTHEQPHTQ 412
Cdd:PRK12757 174 KVEAEKEKEQ 183
PHA03247 PHA03247
large tegument protein UL36; Provisional
 47-339 7.55e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 7.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141   47 PQAPLPMAVSRGLPPQQPQQPLLNLQGTNSASLLNGSMLQRALLLQQLQGLDqfAMPPAtyDTAGLTMPTATLGNLRGYG 126
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA--PAPPA--APAAGPPRRLTRPAVASLS 2792

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  127 MASPGLAAPS--LTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSqfnLSGRNPQKQARTSSSTTP----NRKDSSS 200
Cdd:PHA03247 2793 ESRESLPSPWdpADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP---PPPGPPPPSLPLGGSVAPggdvRRRPPSR 2869

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115141  201 QTMPVEDKSDPPEGSEEAAEPRMDTPEDQDLPPcpediakekrtpaPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQVK 280
Cdd:PHA03247 2870 SPAAKPAAPARPPVRRLARPAVSRSTESFALPP-------------DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP 2936

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 196115141  281 AQPQARmtvPKQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQP 339
Cdd:PHA03247 2937 PRPQPP---LAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASS 2992
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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