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Conserved domains on  [gi|207028673|ref|NP_001128713|]
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aldo-keto reductase family 1 member C2 isoform 2 [Homo sapiens]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 6-123 5.19e-93

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19108:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 303  Bit Score: 271.03  E-value: 5.19e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   6 QCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKL 85
Cdd:cd19108    1 QRVKLNDGHFIPVLGFGTYAPEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKL 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 207028673  86 WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Cdd:cd19108   81 WCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALK 118
 
Name Accession Description Interval E-value
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 6-123 5.19e-93

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 271.03  E-value: 5.19e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   6 QCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKL 85
Cdd:cd19108    1 QRVKLNDGHFIPVLGFGTYAPEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKL 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 207028673  86 WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Cdd:cd19108   81 WCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALK 118
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 12-123 1.10e-46

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 151.36  E-value: 1.10e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  12 DGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKLWSNSHR 91
Cdd:COG0656    1 NGVEIPALGLGTW---QLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA----ASGVPREELFVTTKVWNDNHG 73

                         90       100       110
                 ....*....|....*....|....*....|..
gi 207028673  92 PELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Cdd:COG0656   74 YDDTLAAFEESLERLGLDYLDLYLIHWPGPGP 105
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
8-120 2.27e-32

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 115.17  E-value: 2.27e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   8 VKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSkiadGSVKREDIFYTSKLWS 87
Cdd:PRK11565   7 IKLQDGNVMPQLGLGVW---QASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKE----ASVAREELFITTKLWN 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 207028673  88 NSHRPelVRPALERSLKNLQLDYVDLYLIHFPV 120
Cdd:PRK11565  80 DDHKR--PREALEESLKKLQLDYVDLYLMHWPV 110
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 19-119 5.61e-24

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 93.53  E-value: 5.61e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   19 LGFGTYA----PAEVPKSKALEAVKLAIEAGFHHIDSAHVYN---NEEQVGLAIrskiADGSVKREDIFYTSKL------ 85
Cdd:pfam00248   1 IGLGTWQlgggWGPISKEEALEALRAALEAGINFIDTAEVYGdgkSEELLGEAL----KDYPVKRDKVVIATKVpdgdgp 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 207028673   86 WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:pfam00248  77 WPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWP 110
 
Name Accession Description Interval E-value
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 6-123 5.19e-93

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 271.03  E-value: 5.19e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   6 QCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKL 85
Cdd:cd19108    1 QRVKLNDGHFIPVLGFGTYAPEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKL 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 207028673  86 WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Cdd:cd19108   81 WCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALK 118
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 7-125 1.85e-58

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 182.48  E-value: 1.85e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   7 CVKLNDGHFMPVLGFGTYApaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLW 86
Cdd:cd19116    2 TIKLNDGNEIPAIALGTWK--LKDDEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDLFITTKLW 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 207028673  87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKED 125
Cdd:cd19116   80 NSYHEREQVEPALRESLKRLGLDYVDLYLIHWPVAFKEN 118
AKR_AKR1D1-3 cd19109
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...
 13-123 2.71e-52

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.


Pssm-ID: 381335 [Multi-domain]  Cd Length: 308  Bit Score: 167.28  E-value: 2.71e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  13 GHFMPVLGFGTYA-PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHR 91
Cdd:cd19109    1 GNSIPIIGLGTYSePKTTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWNTCHP 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 207028673  92 PELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Cdd:cd19109   81 PELVRPTLERTLKVLQLDYVDLYIIEMPMAFK 112
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 8-128 3.78e-50

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 161.42  E-value: 3.78e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   8 VKLNDGHFMPVLGFGTYAPAevpKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWS 87
Cdd:cd19123    4 LPLSNGDLIPALGLGTWKSK---PGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDLWITSKLWN 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 207028673  88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKEDIGI 128
Cdd:cd19123   81 NSHAPEDVLPALEKTLADLQLDYLDLYLMHWPVALKKGVGF 121
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 16-134 5.59e-49

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 157.26  E-value: 5.59e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  16 MPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIadgsVKREDIFYTSKLWSNSHRPELV 95
Cdd:cd19071    1 MPLIGLGTY---KLKPEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESG----VPREELFITTKLWPTDHGYERV 73

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 207028673  96 RPALERSLKNLQLDYVDLYLIHFPVSVKEDIGILTWKKS 134
Cdd:cd19071   74 REALEESLKDLGLDYLDLYLIHWPVPGKEGGSKEARLET 112
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 6-125 1.67e-48

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 157.12  E-value: 1.67e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   6 QCVKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKL 85
Cdd:cd19125    1 RFFKLNTGAKIPAVGLGTW---QADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDLFITSKL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 207028673  86 WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKED 125
Cdd:cd19125   78 WCTDHAPEDVPPALEKTLKDLQLDYLDLYLIHWPVRLKKG 117
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 12-123 1.10e-46

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 151.36  E-value: 1.10e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  12 DGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKLWSNSHR 91
Cdd:COG0656    1 NGVEIPALGLGTW---QLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA----ASGVPREELFVTTKVWNDNHG 73

                         90       100       110
                 ....*....|....*....|....*....|..
gi 207028673  92 PELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Cdd:COG0656   74 YDDTLAAFEESLERLGLDYLDLYLIHWPGPGP 105
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
 10-123 2.63e-45

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 148.71  E-value: 2.63e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  10 LNDGHFMPVLGFGTY--APAEVPKskaleAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIAD-GSVKREDIFYTSKLW 86
Cdd:cd19118    1 LNTGNKIPAIGLGTWqaEPGEVGA-----AVKIALKAGYRHLDLAKVYQNQHEVGQALKELLKEePGVKREDLFITSKLW 75

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 207028673  87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Cdd:cd19118   76 NNSHRPEYVEPALDDTLKELGLDYLDLYLIHWPVAFK 112
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 10-123 5.33e-45

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 148.69  E-value: 5.33e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  10 LNDGHFMPVLGFGTY--APAEVPkskalEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKI-ADGSVKREDIFYTSKLW 86
Cdd:cd19106    1 LHTGQKMPLIGLGTWksKPGQVK-----AAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKVgPGKAVPREDLFVTSKLW 75

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 207028673  87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Cdd:cd19106   76 NTKHHPEDVEPALRKTLKDLQLDYLDLYLIHWPYAFE 112
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 7-127 2.85e-44

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 146.79  E-value: 2.85e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   7 CVKLNDGHFMPVLGFGTY--APAEVpkskaLEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSK 84
Cdd:cd19154    3 SITLSNGVKMPLIGLGTWqsKGAEG-----ITAVRTALKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDLFITTK 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 207028673  85 LWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKEDIG 127
Cdd:cd19154   78 LWTHEHAPEDVEEALRESLKKLQLEYVDLYLIHAPAAFKDDEG 120
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 11-123 2.31e-42

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 141.44  E-value: 2.31e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  11 NDGHFMPVLGFGTYAPaevPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSH 90
Cdd:cd19129    1 NGSGAIPALGFGTLIP---DPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRREDLFVTTKLWNTNH 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 207028673  91 RPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Cdd:cd19129   78 RPERVKPAFEASLKRLQLDYLDLYLIHTPFAFQ 110
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
 16-123 1.40e-41

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 139.86  E-value: 1.40e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  16 MPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELV 95
Cdd:cd19107    4 MPILGLGTW---KSPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEKGLV 80

                         90       100
                 ....*....|....*....|....*...
gi 207028673  96 RPALERSLKNLQLDYVDLYLIHFPVSVK 123
Cdd:cd19107   81 KGACQKTLSDLKLDYLDLYLIHWPTGFK 108
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
 12-125 4.96e-41

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 137.78  E-value: 4.96e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  12 DGHFMPVLGFGTYAPAEVPKsKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVK-REDIFYTSKLWSNSH 90
Cdd:cd19124    1 SGQTMPVIGMGTASDPPSPE-DIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVKsRDELFVTSKLWCSDA 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 207028673  91 RPELVRPALERSLKNLQLDYVDLYLIHFPVSVKED 125
Cdd:cd19124   80 HPDLVLPALKKSLRNLQLEYVDLYLIHWPVSLKPG 114
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 8-132 3.47e-39

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 132.11  E-value: 3.47e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   8 VKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKLWS 87
Cdd:cd19131    2 ITLNDGNTIPQLGLGVW---QVSNDEAASAVREALEVGYRSIDTAAIYGNEEGVGKAIR----ASGVPREELFITTKLWN 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 207028673  88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSvKEDIGILTWK 132
Cdd:cd19131   75 SDQGYDSTLRAFDESLRKLGLDYVDLYLIHWPVP-AQDKYVETWK 118
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 8-120 2.98e-38

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 130.00  E-value: 2.98e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   8 VKLNDGHFMPVLGFGTYapaEVP-KSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKLW 86
Cdd:cd19133    1 VTLNNGVEMPILGFGVF---QIPdPEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIK----KSGIPREELFITTKLW 73

                         90       100       110
                 ....*....|....*....|....*....|....
gi 207028673  87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 120
Cdd:cd19133   74 IQDAGYEKAKKAFERSLKRLGLDYLDLYLIHQPF 107
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
 16-123 2.38e-37

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 128.92  E-value: 2.38e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  16 MPVLGFGTY--APAEVPkskalEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPE 93
Cdd:cd19110    4 IPAVGLGTWkaSPGEVT-----EAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKS 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 207028673  94 LVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Cdd:cd19110   79 LVKTACTRSLKALKLNYLDLYLIHWPMGFK 108
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 17-125 2.62e-37

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 128.02  E-value: 2.62e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVR 96
Cdd:cd19128    2 PRLGFGTY---KITESESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDLFITSKLWPTMHQPENVK 78

                         90       100
                 ....*....|....*....|....*....
gi 207028673  97 PALERSLKNLQLDYVDLYLIHFPVSVKED 125
Cdd:cd19128   79 EQLLITLQDLQLEYLDLFLIHWPLAFDMD 107
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
 16-130 3.42e-37

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 126.62  E-value: 3.42e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  16 MPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIrskiADGSVKREDIFYTSKLWSNSHRPELV 95
Cdd:cd19073    1 IPALGLGTW---QLRGDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAI----AESGVPREDLFITTKVWRDHLRPEDL 73

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 207028673  96 RPALERSLKNLQLDYVDLYLIHFP---VSVKEDIGILT 130
Cdd:cd19073   74 KKSVDRSLEKLGTDYVDLLLIHWPnptVPLEETLGALK 111
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 8-123 4.41e-37

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 128.33  E-value: 4.41e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   8 VKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWS 87
Cdd:cd19113    3 IKLNSGYKMPSVGFGCW---KLDNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKLWN 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 207028673  88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Cdd:cd19113   80 NFHDPKNVETALNKTLSDLKLDYVDLFLIHFPIAFK 115
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
 7-125 7.84e-37

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 127.64  E-value: 7.84e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   7 CVKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLW 86
Cdd:cd19155    3 CVTFNNGEKMPVVGLGTW---QSSPEEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKREELFIVTKLP 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 207028673  87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSV--KED 125
Cdd:cd19155   80 PGGNRREKVEKFLLKSLEKLQLDYVDLYLIHFPVGSlsKED 120
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
 13-125 7.26e-36

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 124.53  E-value: 7.26e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  13 GHFMPVLGFGTY--APAEVpkskaLEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSH 90
Cdd:cd19111    1 GFPMPVIGLGTYqsPPEEV-----RAAVDYALFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEVFITTKLPPVYL 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 207028673  91 RPELVRPALERSLKNLQLDYVDLYLIHFPVSVKED 125
Cdd:cd19111   76 EFKDTEKSLEKSLENLKLPYVDLYLIHHPCGFVNK 110
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
 8-135 9.33e-36

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 124.53  E-value: 9.33e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   8 VKLNDGHFMPVLGFGTYAPAEvPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWS 87
Cdd:cd19119    4 FKLNTGASIPALGLGTASPHE-DRAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREELFITTKVWP 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 207028673  88 NSHRPelVRPALERSLKNLQLDYVDLYLIHFPVSV---KEDIGILTWKKSP 135
Cdd:cd19119   83 TFYDE--VERSLDESLKALGLDYVDLLLVHWPVCFekdSDDSGKPFTPVND 131
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 8-132 9.70e-36

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 123.32  E-value: 9.70e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   8 VKLNDGHFMPVLGFGTYapaEVPK-SKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSkiadGSVKREDIFYTSKLW 86
Cdd:cd19126    1 VTLNNGTRMPWLGLGVF---QTPDgDETERAVQTALENGYRSIDTAAIYKNEEGVGEAIRE----SGVPREELFVTTKLW 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 207028673  87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVsvkEDIGILTWK 132
Cdd:cd19126   74 NDDQRARRTEDAFQESLDRLGLDYVDLYLIHWPG---KDKFIDTWK 116
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 9-120 2.81e-35

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 123.02  E-value: 2.81e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   9 KLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGsVKREDIFYTSKLWSN 88
Cdd:cd19121    5 KLNTGASIPAVGLGTW---QAKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAIAGG-VKREDLFVTTKLWST 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 207028673  89 SH-RPELvrpALERSLKNLQLDYVDLYLIHFPV 120
Cdd:cd19121   81 YHrRVEL---CLDRSLKSLGLDYVDLYLVHWPV 110
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
 13-129 3.70e-35

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 121.98  E-value: 3.70e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  13 GHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIrskiADGSVKREDIFYTSKLWSNSHRP 92
Cdd:cd19140    5 GVRIPALGLGTY---PLTGEECTRAVEHALELGYRHIDTAQMYGNEAQVGEAI----AASGVPRDELFLTTKVWPDNYSP 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 207028673  93 ELVRPALERSLKNLQLDYVDLYLIHFP---VSVKEDIGIL 129
Cdd:cd19140   78 DDFLASVEESLRKLRTDYVDLLLLHWPnkdVPLAETLGAL 117
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
 8-123 8.28e-35

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 122.21  E-value: 8.28e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   8 VKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWS 87
Cdd:cd19112    3 ITLNSGHKMPVIGLGVW---RMEPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDLFITTKLWN 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 207028673  88 NSHrpELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Cdd:cd19112   80 SDH--GHVIEACKDSLKKLQLDYLDLYLVHFPVATK 113
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 13-132 8.31e-35

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 121.19  E-value: 8.31e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  13 GHFMPVLGFGT----YAPAEVPKSKAL-EAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKLWS 87
Cdd:cd19120    1 GSKIPAIAFGTgtawYKSGDDDIQRDLvDSVKLALKAGFRHIDTAEMYGNEKEVGEALK----ESGVPREDLFITTKVSP 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 207028673  88 NSHRPelvRPALERSLKNLQLDYVDLYLIHFPVSVKEDIGILT--WK 132
Cdd:cd19120   77 GIKDP---REALRKSLAKLGVDYVDLYLIHSPFFAKEGGPTLAeaWA 120
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
 10-132 8.99e-35

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 120.84  E-value: 8.99e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  10 LNDGHFMPVLGFGTYApaeVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSkiadGSVKREDIFYTSKLWSNS 89
Cdd:cd19132    1 LNDGTQIPAIGFGTYP---LKGDEGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVRR----SGVPREELFVTTKLPGRH 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 207028673  90 HRPELVRPALERSLKNLQLDYVDLYLIHFPVSvKEDIGILTWK 132
Cdd:cd19132   74 HGYEEALRTIEESLYRLGLDYVDLYLIHWPNP-SRDLYVEAWQ 115
AKR_AKR2D1 cd19115
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...
 8-135 1.59e-34

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.


Pssm-ID: 381341 [Multi-domain]  Cd Length: 311  Bit Score: 121.76  E-value: 1.59e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   8 VKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWS 87
Cdd:cd19115    5 VKLNSGYDMPLVGFGLW---KVNNDTCADQVYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDLFIVSKLWN 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 207028673  88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK-------------EDIGILTWKKSP 135
Cdd:cd19115   82 TFHDGERVEPICRKQLADWGIDYFDLFLIHFPIALKyvdpavryppgwfYDGKKVEFSNAP 142
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 7-132 2.31e-34

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 120.19  E-value: 2.31e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   7 CVKLNDGHFMPVLGFGTYapaEVPK-SKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKL 85
Cdd:cd19157    1 TVTLNNGVKMPWLGLGVF---KVEEgSEVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGIK----ESGIPREELFITSKV 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 207028673  86 WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPvsvKEDIGILTWK 132
Cdd:cd19157   74 WNADQGYDSTLKAFEASLERLGLDYLDLYLIHWP---VKGKYKETWK 117
AKR_AKR2C1 cd19114
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...
 13-123 2.67e-34

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.


Pssm-ID: 381340 [Multi-domain]  Cd Length: 302  Bit Score: 120.74  E-value: 2.67e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  13 GHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRP 92
Cdd:cd19114    1 GDKMPLVGFGTA---KIKANETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKREDLFIVTKLWNNFHGK 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 207028673  93 ELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123
Cdd:cd19114   78 DHVREAFDRQLKDYGLDYIDLYLIHFPIPAA 108
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 9-125 8.30e-34

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 119.14  E-value: 8.30e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   9 KLNDGHFMPVLGFGTY--APAEVPKskaleAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKLW 86
Cdd:cd19117    7 KLNTGAEIPAVGLGTWqsKPNEVAK-----AVEAALKAGYRHIDTAAIYGNEEEVGQGIK----DSGVPREEIFITTKLW 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 207028673  87 SNSHRPelVRPALERSLKNLQLDYVDLYLIHFPVSVKED 125
Cdd:cd19117   78 CTWHRR--VEEALDQSLKKLGLDYVDLYLMHWPVPLDPD 114
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 16-119 5.83e-33

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 116.58  E-value: 5.83e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  16 MPVLGFGTY---APAEVpkSKALEAvklAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRP 92
Cdd:cd19136    1 MPILGLGTFrlrGEEEV--RQAVDA---ALKAGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDIFITSKLAPKDQGY 75

                         90       100
                 ....*....|....*....|....*..
gi 207028673  93 ELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19136   76 EKARAACLGSLERLGTDYLDLYLIHWP 102
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
8-120 2.27e-32

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 115.17  E-value: 2.27e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   8 VKLNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSkiadGSVKREDIFYTSKLWS 87
Cdd:PRK11565   7 IKLQDGNVMPQLGLGVW---QASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKE----ASVAREELFITTKLWN 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 207028673  88 NSHRPelVRPALERSLKNLQLDYVDLYLIHFPV 120
Cdd:PRK11565  80 DDHKR--PREALEESLKKLQLDYVDLYLMHWPV 110
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 8-132 2.50e-32

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 114.81  E-value: 2.50e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   8 VKLNDGHFMPVLGFGTYApaeVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKiadgSVKREDIFYTSKLWS 87
Cdd:cd19127    1 ITLNNGVEMPALGLGVFQ---TPPEETADAVATALADGYRLIDTAAAYGNEREVGEGIRRS----GVDRSDIFVTTKLWI 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 207028673  88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKEDIGILTWK 132
Cdd:cd19127   74 SDYGYDKALRGFDASLRRLGLDYVDLYLLHWPVPNDFDRTIQAYK 118
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 8-132 4.90e-32

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 114.15  E-value: 4.90e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   8 VKLNDGHFMPVLGFGTYAPAEvpKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKiadgSVKREDIFYTSKLWS 87
Cdd:cd19156    1 VKLANGVEMPRLGLGVWRVQD--GAEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIRES----GVPREEVFVTTKLWN 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 207028673  88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKEdigILTWK 132
Cdd:cd19156   75 SDQGYESTLAAFEESLEKLGLDYVDLYLIHWPVKGKF---KDTWK 116
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
 10-133 5.87e-32

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 113.85  E-value: 5.87e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  10 LNDGHFMPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIrskiADGSVKREDIFYTSKLWSNS 89
Cdd:cd19130    4 LNDGNSIPQLGYGVF---KVPPADTQRAVATALEVGYRHIDTAAIYGNEEGVGAAI----AASGIPRDELFVTTKLWNDR 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 207028673  90 HRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKEDIgILTWKK 133
Cdd:cd19130   77 HDGDEPAAAFAESLAKLGLDQVDLYLVHWPTPAAGNY-VHTWEA 119
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 9-125 2.62e-31

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 112.72  E-value: 2.62e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   9 KLNDGHFMPVLGFGTYApAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADG-SVKREDIFYTSKLWS 87
Cdd:cd19122    2 TLNNGVKIPAVGFGTFA-NEGAKGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLKENpSVKREDLFICTKVWN 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 207028673  88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKED 125
Cdd:cd19122   81 HLHEPEDVKWSIDNSLKNLKLDYIDLFLVHWPIAAEKN 118
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
 16-129 4.08e-30

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 108.86  E-value: 4.08e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  16 MPVLGFGTYA---PAEVPKS---KALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSkiadgsVKREDIFYTSKLW 86
Cdd:cd19072    4 VPVLGLGTWGiggGMSKDYSddkKAIEALRYAIELGINLIDTAEMYGGghaEELVGKAIKG------FDREDLFITTKVS 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 207028673  87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFP---VSVKEDIGIL 129
Cdd:cd19072   78 PDHLKYDDVIKAAKESLKRLGTDYIDLYLIHWPnpsIPIEETLRAM 123
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
 8-119 8.84e-29

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 105.71  E-value: 8.84e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   8 VKLNDGHFMPVLGFGTyapAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKiadgSVKREDIFYTSKLWS 87
Cdd:cd19134    3 VTLNDDNTMPVIGLGV---GELSDDEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIAAS----GIPRGELFVTTKLAT 75

                         90       100       110
                 ....*....|....*....|....*....|..
gi 207028673  88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19134   76 PDQGFTASQAACRASLERLGLDYVDLYLIHWP 107
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
 16-129 4.91e-27

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 100.89  E-value: 4.91e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  16 MPVLGFGTY--APAEVPKSkaleaVKLAIEAGFHHIDSAHVYNNEEQVGLAIrskiADGSVKREDIFYTSKLWSNSHRPE 93
Cdd:cd19139    1 IPAFGLGTFrlKDDVVIDS-----VRTALELGYRHIDTAQIYDNEAAVGQAI----AESGVPRDELFITTKIWIDNLSKD 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 207028673  94 LVRPALERSLKNLQLDYVDLYLIHFP-----VSVKEDIGIL 129
Cdd:cd19139   72 KLLPSLEESLEKLRTDYVDLTLIHWPspndeVPVEEYIGAL 112
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 7-137 5.46e-27

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 100.86  E-value: 5.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   7 CVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKlaiEAGFHHIDSAHVYNNEEQVGLAIRskiaDGSVKREDIFYTSKLW 86
Cdd:cd19135    4 TVRLSNGVEMPILGLGTSHSGGYSHEAVVYALK---ECGYRHIDTAKRYGCEELLGKAIK----ESGVPREDLFLTTKLW 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 207028673  87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVkedigilTWKKSPKH 137
Cdd:cd19135   77 PSDYGYESTKQAFEASLKRLGVDYLDLYLLHWPDCP-------SSGKNVKE 120
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
 6-122 1.27e-26

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 100.02  E-value: 1.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   6 QCVKLNDGHFMPVLGFGTYAPAEVPKSKA--LEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkREDIF 80
Cdd:cd19138    1 RTVTLPDGTKVPALGQGTWYMGEDPAKRAqeIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRGR-------RDKVF 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 207028673  81 YTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSV 122
Cdd:cd19138   74 LVSKVLPSNASRQGTVRACERSLRRLGTDYLDLYLLHWRGGV 115
dkgB PRK11172
2,5-didehydrogluconate reductase DkgB;
16-124 8.09e-26

2,5-didehydrogluconate reductase DkgB;


Pssm-ID: 183012 [Multi-domain]  Cd Length: 267  Bit Score: 97.79  E-value: 8.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  16 MPVLGFGTYapaEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIrskiADGSVKREDIFYTSKLWSNSHRPELV 95
Cdd:PRK11172   3 IPAFGLGTF---RLKDQVVIDSVKTALELGYRAIDTAQIYDNEAAVGQAI----AESGVPRDELFITTKIWIDNLAKDKL 75

                         90       100       110
                 ....*....|....*....|....*....|....
gi 207028673  96 RPALERSLKNLQLDYVDLYLIHFP-----VSVKE 124
Cdd:PRK11172  76 IPSLKESLQKLRTDYVDLTLIHWPspndeVSVEE 109
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 19-119 5.61e-24

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 93.53  E-value: 5.61e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673   19 LGFGTYA----PAEVPKSKALEAVKLAIEAGFHHIDSAHVYN---NEEQVGLAIrskiADGSVKREDIFYTSKL------ 85
Cdd:pfam00248   1 IGLGTWQlgggWGPISKEEALEALRAALEAGINFIDTAEVYGdgkSEELLGEAL----KDYPVKRDKVVIATKVpdgdgp 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 207028673   86 WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:pfam00248  77 WPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWP 110
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
 17-129 7.47e-24

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 93.42  E-value: 7.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGTYAPA------EVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkREDIFYTSKLWS 87
Cdd:cd19085    2 SRLGLGCWQFGggywwgDQDDEESIATIHAALDAGINFFDTAEAYGDghsEEVLGKALKGR-------RDDVVIATKVSP 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 207028673  88 NSHRPELVRPALERSLKNLQLDYVDLYLIHFP---VSVKEDIGIL 129
Cdd:cd19085   75 DNLTPEDVRKSCERSLKRLGTDYIDLYQIHWPssdVPLEETMEAL 119
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
 13-119 4.43e-22

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 88.74  E-value: 4.43e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  13 GHFMPVLGFGTYA-----PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkREDIFYTSK 84
Cdd:cd19084    1 DLKVSRIGLGTWAiggtwWGEVDDQESIEAIKAAIDLGINFFDTAPVYGFghsEEILGKALKGR-------RDDVVIATK 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 207028673  85 ---LWSNSH------RPELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19084   74 cglRWDGGKgvtkdlSPESIRKEVEQSLRRLQTDYIDLYQIHWP 117
AKR_unchar cd19100
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 17-124 1.31e-21

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381326 [Multi-domain]  Cd Length: 238  Bit Score: 86.38  E-value: 1.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN-EEQVGLAIRSKiadgsvkREDIFYTSKLWSNShrPELV 95
Cdd:cd19100   12 SRLGFGGGPLGRLSQEEAAAIIRRALDLGINYFDTAPSYGDsEEKIGKALKGR-------RDKVFLATKTGARD--YEGA 82

                         90       100
                 ....*....|....*....|....*....
gi 207028673  96 RPALERSLKNLQLDYVDLYLIHFPVSVKE 124
Cdd:cd19100   83 KRDLERSLKRLGTDYIDLYQLHAVDTEED 111
COG1453 COG1453
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
16-117 3.66e-21

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];


Pssm-ID: 441062 [Multi-domain]  Cd Length: 365  Bit Score: 87.18  E-value: 3.66e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  16 MPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVY-NNEEQVGLAIRSKiadgsvkREDIFYTSKLWSNSHRPEL 94
Cdd:COG1453   13 VSVLGFGGMRLPRKDEEEAEALIRRAIDNGINYIDTARGYgDSEEFLGKALKGP-------RDKVILATKLPPWVRDPED 85

                         90       100
                 ....*....|....*....|...
gi 207028673  95 VRPALERSLKNLQLDYVDLYLIH 117
Cdd:COG1453   86 MRKDLEESLKRLQTDYIDLYLIH 108
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
 13-119 1.03e-20

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 84.54  E-value: 1.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  13 GHFMPVLGFGTYA------PAEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSkiadgsVKREDIFYTS 83
Cdd:cd19137    1 GEKIPALGLGTWGiggfltPDYSRDEEMVELLKTAIELGYTHIDTAEMYgggHTEELVGKAIKD------FPREDLFIVT 74

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 207028673  84 KLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19137   75 KVWPTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWP 110
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 17-119 2.82e-20

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 82.57  E-value: 2.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGTYA-PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRskiadGSVKREDIFYTSK-----LWS 87
Cdd:cd06660    1 SRLGLGTMTfGGDGDEEEAFALLDAALEAGGNFFDTADVYGDgrsERLLGRWLK-----GRGNRDDVVIATKgghppGGD 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 207028673  88 NSHR---PELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd06660   76 PSRSrlsPEHIRRDLEESLRRLGTDYIDLYYLHRD 110
AKR_unchar cd19105
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 13-117 1.25e-19

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381331 [Multi-domain]  Cd Length: 250  Bit Score: 81.48  E-value: 1.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  13 GHFMPVLGFGTYAPAevpkSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSkiadgsVKREDIFYTSK--LWS 87
Cdd:cd19105   10 GLKVSRLGFGGGGLP----RESPELLRRALDLGINYFDTAEGYgngNSEEIIGEALKG------LRRDKVFLATKasPRL 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 207028673  88 NSHRPELVRPALERSLKNLQLDYVDLYLIH 117
Cdd:cd19105   80 DKKDKAELLKSVEESLKRLQTDYIDIYQLH 109
AKR_Fe-S_oxidoreductase cd19096
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...
 17-117 9.42e-19

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381322 [Multi-domain]  Cd Length: 255  Bit Score: 79.14  E-value: 9.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGTY-----APAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSkiadgsVKREDIFYTSKL-WS 87
Cdd:cd19096    1 SVLGFGTMrlpesDDDSIDEEKAIEMIRYAIDAGINYFDTAYGYGGgksEEILGEALKE------GPREKFYLATKLpPW 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 207028673  88 NSHRPELVRPALERSLKNLQLDYVDLYLIH 117
Cdd:cd19096   75 SVKSAEDFRRILEESLKRLGVDYIDFYLLH 104
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
 17-119 1.32e-18

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 79.45  E-value: 1.32e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGT----YAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYN---NEEQVGLAIRSKiadgsvKREDIFYTSKL---- 85
Cdd:COG0667   14 SRLGLGTmtfgGPWGGVDEAEAIAILDAALDAGINFFDTADVYGpgrSEELLGEALKGR------PRDDVVIATKVgrrm 87

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 207028673  86 ----WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:COG0667   88 gpgpNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRP 125
AKR_PA4992-like cd19095
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ...
 17-131 1.36e-17

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381321 [Multi-domain]  Cd Length: 253  Bit Score: 76.12  E-value: 1.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGTY----APAEVPKSKALEAVKLAIEAGFHHIDSAHVY-NNEEQVGLAIRSkiadgsVKREDIFYTSKLWSNS-- 89
Cdd:cd19095    1 SVLGLGTSgigrVWGVPSEAEAARLLNTALDLGINLIDTAPAYgRSEERLGRALAG------LRRDDLFIATKVGTHGeg 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 207028673  90 ------HRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKEDIGILTW 131
Cdd:cd19095   75 grdrkdFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLET 122
AKR_AKR15A-like cd19090
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ...
 17-119 1.01e-16

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381316 [Multi-domain]  Cd Length: 278  Bit Score: 74.13  E-value: 1.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGTY----APAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN-EEQVGLAIRSkiadgsVKREDIFYTSKL-----W 86
Cdd:cd19090    1 SALGLGTAglggVFGGVDDDEAVATIRAALDLGINYIDTAPAYGDsEERLGLALAE------LPREPLVLSTKVgrlpeD 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 207028673  87 SNSHRPELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19090   75 TADYSADRVRRSVEESLERLGRDRIDLLMIHDP 107
AKR_unchar cd19099
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 19-119 1.48e-16

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381325 [Multi-domain]  Cd Length: 316  Bit Score: 73.89  E-value: 1.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  19 LGFGTY--APAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKIADGSVKREDIFYTSK--------- 84
Cdd:cd19099    6 LGLGTYrgDSDDETDEEYREALKAALDSGINVIDTAINYRGgrsERLIGKALRELIEKGGIKRDEVVIVTKagyipgdgd 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  85 -------------------------LWSNSHrPELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19099   86 eplrplkyleeklgrglidvadsagLRHCIS-PAYLEDQIERSLKRLGLDTIDLYLLHNP 144
AKR_AKR11C1 cd19086
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...
 18-119 8.47e-16

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.


Pssm-ID: 381312 [Multi-domain]  Cd Length: 238  Bit Score: 70.97  E-value: 8.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  18 VLGFGTYA-----PAEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgsvkREDIFYTSKL---- 85
Cdd:cd19086    5 EIGFGTWGlggdwWGDVDDAEAIRALRAALDLGINFFDTADVYgdgHSERLLGKALKGR-------RDKVVIATKFgnrf 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 207028673  86 -----WSNSHRPELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19086   78 dggpeRPQDFSPEYIREAVEASLKRLGTDYIDLYQLHNP 116
AKR_AKR13A1 cd19144
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ...
 11-117 2.92e-14

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.


Pssm-ID: 381370 [Multi-domain]  Cd Length: 323  Bit Score: 67.85  E-value: 2.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  11 NDGHFMPVLGFGT------YAPAEvPKSKALEAVKLAIEAGFHHIDSAHVY-NNEEQVGLAIrsKIADGsvKREDIFYTS 83
Cdd:cd19144    8 RNGPSVPALGFGAmglsafYGPPK-PDEERFAVLDAAFELGCTFWDTADIYgDSEELIGRWF--KQNPG--KREKIFLAT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 207028673  84 K-----------LWSNShRPELVRPALERSLKNLQLDYVDLYLIH 117
Cdd:cd19144   83 KfgieknvetgeYSVDG-SPEYVKKACETSLKRLGVDYIDLYYQH 126
AKR_AKR11A1_11D1 cd19083
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...
 38-119 3.50e-14

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).


Pssm-ID: 381309 [Multi-domain]  Cd Length: 307  Bit Score: 67.44  E-value: 3.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  38 VKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgsvKREDIFYTSK----------LWSNShrPELVRPALERSLK 104
Cdd:cd19083   39 VREALDNGVNLLDTAFIYglgRSEELVGEVLKEY------NRNEVVIATKgahkfggdgsVLNNS--PEFLRSAVEKSLK 110

                         90
                 ....*....|....*
gi 207028673 105 NLQLDYVDLYLIHFP 119
Cdd:cd19083  111 RLNTDYIDLYYIHFP 125
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
 11-117 7.66e-14

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 66.48  E-value: 7.66e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  11 NDGHFMPVLGFG--TYAPAEVPKSK--------ALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkRE 77
Cdd:cd19091    8 RSGLKVSELALGtmTFGGGGGFFGAwggvdqeeADRLVDIALDAGINFFDTADVYSEgesEEILGKALKGR-------RD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 207028673  78 DIFYTSKLW---------SNSHRPELVRpALERSLKNLQLDYVDLYLIH 117
Cdd:cd19091   81 DVLIATKVRgrmgegpndVGLSRHHIIR-AVEASLKRLGTDYIDLYQLH 128
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 18-119 8.20e-14

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 66.16  E-value: 8.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  18 VLGFGTYA---------PAEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgsvkREDIFYTSK- 84
Cdd:cd19102    3 TIGLGTWAiggggwgggWGPQDDRDSIAAIRAALDLGINWIDTAAVYglgHSEEVVGRALKGL-------RDRPIVATKc 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 207028673  85 --LW------SNSHRPELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19102   76 glLWdeegriRRSLKPASIRAECEASLRRLGVDVIDLYQIHWP 118
AKR_AtPLR-like cd19093
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...
 17-122 2.77e-13

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.


Pssm-ID: 381319 [Multi-domain]  Cd Length: 293  Bit Score: 64.94  E-value: 2.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGTYA---------PAEVPKSkALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRskiadGSVKREDIFYTSK 84
Cdd:cd19093    3 SPLGLGTWQwgdrlwwgyGEYGDED-LQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFLK-----ELGDRDEVVIATK 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 207028673  85 L----WSNSHRPeLVRpALERSLKNLQLDYVDLYLIHFPVSV 122
Cdd:cd19093   77 FaplpWRLTRRS-VVK-ALKASLERLGLDSIDLYQLHWPGPW 116
Aldo_ket_red_shaker-like cd19074
Shaker potassium channel beta subunit family and similar proteins; This family includes ...
 18-117 3.59e-13

Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381300 [Multi-domain]  Cd Length: 297  Bit Score: 64.54  E-value: 3.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  18 VLGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSkiadgsVKREDIFYTSKL-WSNSHR 91
Cdd:cd19074    6 ELSLGTWLTfgGQVDDEDAKACVRKAYDLGINFFDTADVYAAgqaEEVLGKALKG------WPRESYVISTKVfWPTGPG 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 207028673  92 PE---LVRP----ALERSLKNLQLDYVDLYLIH 117
Cdd:cd19074   80 PNdrgLSRKhifeSIHASLKRLQLDYVDIYYCH 112
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
 29-117 3.07e-12

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 61.83  E-value: 3.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  29 VPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKIadgsvKREDIFYTSKLWSNSH---------RPELVR 96
Cdd:cd19079   32 LDEEESRPIIKRALDLGINFFDTANVYSGgasEEILGRALKEFA-----PRDEVVIATKVYFPMGdgpngrglsRKHIMA 106

                         90       100
                 ....*....|....*....|.
gi 207028673  97 pALERSLKNLQLDYVDLYLIH 117
Cdd:cd19079  107 -EVDASLKRLGTDYIDLYQIH 126
AKR_AKR11B2 cd19149
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...
 17-119 7.95e-12

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381375 [Multi-domain]  Cd Length: 315  Bit Score: 60.75  E-value: 7.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGTYA------PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkREDIFYTSK--- 84
Cdd:cd19149   12 SVIGLGTWAigggpwWGGSDDNESIRTIHAALDLGINLIDTAPAYGFghsEEIVGKAIKGR-------RDKVVLATKcgl 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 207028673  85 LWSNSH----------------RPELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19149   85 RWDREGgsfffvrdgvtvyknlSPESIREEVEQSLKRLGTDYIDLYQTHWQ 135
AKR_AKR13A_13D cd19076
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...
 17-117 1.18e-11

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381302 [Multi-domain]  Cd Length: 303  Bit Score: 60.31  E-value: 1.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGT------YAPAEVPKSKALeaVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgsvkREDIFYTSK--- 84
Cdd:cd19076   13 SALGLGCmgmsafYGPADEEESIAT--LHRALELGVTFLDTADMYgpgTNEELLGKALKDR-------RDEVVIATKfgi 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 207028673  85 LWS-------NSHRPELVRPALERSLKNLQLDYVDLYLIH 117
Cdd:cd19076   84 VRDpgsgfrgVDGRPEYVRAACEASLKRLGTDVIDLYYQH 123
AKR_AKR13C1_2 cd19078
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...
 19-117 1.82e-11

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.


Pssm-ID: 381304 [Multi-domain]  Cd Length: 301  Bit Score: 59.94  E-value: 1.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  19 LGFG----TYAPAEVP-KSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgsvkREDIFYTSK------ 84
Cdd:cd19078    7 IGLGcmgmSHGYGPPPdKEEMIELIRKAVELGITFFDTAEVYgpyTNEELVGEALKPF-------RDQVVIATKfgfkid 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 207028673  85 ------LWSNShRPELVRPALERSLKNLQLDYVDLYLIH 117
Cdd:cd19078   80 ggkpgpLGLDS-RPEHIRKAVEGSLKRLQTDYIDLYYQH 117
AKR_AKR10A1_2 cd19082
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...
 17-117 5.30e-11

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.


Pssm-ID: 381308 [Multi-domain]  Cd Length: 291  Bit Score: 58.33  E-value: 5.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGT-YAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLA-------IRSKIadgsvKREDIFYTSK---- 84
Cdd:cd19082    1 SRIVLGTaDFGTRIDEEEAFALLDAFVELGGNFIDTARVYGDWVERGAServigewLKSRG-----NRDKVVIATKgghp 75

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 207028673  85 -LWSNS-HR--PELVRPALERSLKNLQLDYVDLYLIH 117
Cdd:cd19082   76 dLEDMSrSRlsPEDIRADLEESLERLGTDYIDLYFLH 112
AKR_AKR11B1 cd19148
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...
 33-119 1.07e-10

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381374 [Multi-domain]  Cd Length: 302  Bit Score: 57.70  E-value: 1.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  33 KALEAVKLAIEAGFHHIDSAHVYN---NEEQVGLAIRskiadGSVKREDIFYTSKL---WSNSH------RPELVRPALE 100
Cdd:cd19148   26 EAIETIHKALDLGINLIDTAPVYGfglSEEIVGKALK-----EYGKRDRVVIATKVgleWDEGGevvrnsSPARIRKEVE 100

                         90
                 ....*....|....*....
gi 207028673 101 RSLKNLQLDYVDLYLIHFP 119
Cdd:cd19148  101 DSLRRLQTDYIDLYQVHWP 119
AKR_AKR13B1 cd19088
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...
 15-129 2.52e-10

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.


Pssm-ID: 381314 [Multi-domain]  Cd Length: 256  Bit Score: 56.46  E-value: 2.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  15 FMPVLGFGTYAPAEvPKSKALEAVKLAIEAGFHHIDSAHVYN---NEEQVGLAIRSKIAD-------GSVKREDifytsK 84
Cdd:cd19088    8 AMRLTGPGIWGPPA-DREEAIAVLRRALELGVNFIDTADSYGpdvNERLIAEALHPYPDDvviatkgGLVRTGP-----G 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 207028673  85 LWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFP---VSVKEDIGIL 129
Cdd:cd19088   82 WWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIdpkVPFEEQLGAL 129
AKR_unchar cd19104
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 34-117 3.43e-10

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381330 [Multi-domain]  Cd Length: 321  Bit Score: 56.12  E-value: 3.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  34 ALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkREDIFYTSKL-WSNSHRPEL---VRPALERSLKNL 106
Cdd:cd19104   34 QIAAVRRALDLGINFFDTAPSYGDgksEENLGRALKGL-------PAGPYITTKVrLDPDDLGDIggqIERSVEKSLKRL 106

                         90
                 ....*....|.
gi 207028673 107 QLDYVDLYLIH 117
Cdd:cd19104  107 KRDSVDLLQLH 117
AKR_AKR12A1_B1_C1 cd19087
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ...
 41-117 6.90e-10

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.


Pssm-ID: 381313 [Multi-domain]  Cd Length: 310  Bit Score: 55.27  E-value: 6.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  41 AIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkREDIFYTSKLW------------SNSHrpelVRPALERSLKN 105
Cdd:cd19087   39 ALDAGINFFDTADVYGGgrsEEIIGRWIAGR-------RDDIVLATKVFgpmgddpndrglSRRH----IRRAVEASLRR 107

                         90
                 ....*....|..
gi 207028673 106 LQLDYVDLYLIH 117
Cdd:cd19087  108 LQTDYIDLYQMH 119
AKR_AKR7A1-5 cd19075
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...
 18-119 8.42e-10

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.


Pssm-ID: 381301 [Multi-domain]  Cd Length: 304  Bit Score: 55.25  E-value: 8.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  18 VLG---FGTYA-PAEVPKSKALeaVKLAIEAGFHHIDSAHVYNN---EEQVGlAIRSKIADGSV--KredifyTSKLWSN 88
Cdd:cd19075    4 ILGtmtFGSQGrFTTAEAAAEL--LDAFLERGHTEIDTARVYPDgtsEELLG-ELGLGERGFKIdtK------ANPGVGG 74

                         90       100       110
                 ....*....|....*....|....*....|.
gi 207028673  89 SHRPELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19075   75 GLSPENVRKQLETSLKRLKVDKVDVFYLHAP 105
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
 18-119 1.01e-09

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 54.87  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  18 VLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgSVKREDIFYTSK----LWSNSH 90
Cdd:cd19092   10 VLGCMRLADWGESAEELLSLIEAALELGITTFDHADIYGGgkcEELFGEALALN----PGLREKIEIQTKcgirLGDDPR 85

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 207028673  91 R---------PELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19092   86 PgrikhydtsKEHILASVEGSLKRLGTDYLDLLLLHRP 123
AKR_AKR6C1_2 cd19143
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ...
 18-119 2.99e-09

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381369 [Multi-domain]  Cd Length: 319  Bit Score: 53.75  E-value: 2.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  18 VLGFG---TYApAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRskiaDGSVKREDIFYTSKL-W---- 86
Cdd:cd19143   15 ALSFGswvTFG-NQVDVDEAKECMKAAYDAGVNFFDNAEVYANgqsEEIMGQAIK----ELGWPRSDYVVSTKIfWgggg 89

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 207028673  87 --SNSH---RPELVRpALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19143   90 ppPNDRglsRKHIVE-GTKASLKRLQLDYVDLVFCHRP 126
AKR_AKR13D1 cd19145
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...
 19-117 6.26e-09

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381371 [Multi-domain]  Cd Length: 304  Bit Score: 52.82  E-value: 6.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  19 LGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKIadgsvkREDIFYTSK----LWSNSHR 91
Cdd:cd19145   20 MGLSGDYGAPKPEEEGIALIHHAFNSGVTFLDTSDIYgpnTNEVLLGKALKDGP------REKVQLATKfgihEIGGSGV 93

                         90       100       110
                 ....*....|....*....|....*....|.
gi 207028673  92 -----PELVRPALERSLKNLQLDYVDLYLIH 117
Cdd:cd19145   94 evrgdPAYVRAACEASLKRLDVDYIDLYYQH 124
AKR_AKR9A_9B cd19080
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ...
 42-119 1.67e-08

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381306 [Multi-domain]  Cd Length: 307  Bit Score: 51.45  E-value: 1.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  42 IEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvkREDIFYTSKLWSN----------SHRPELVRpALERSLKNLQL 108
Cdd:cd19080   41 VEAGGNFIDTANNYTNgtsERLLGEFIAGN-------RDRIVLATKYTMNrrpgdpnaggNHRKNLRR-SVEASLRRLQT 112

                         90
                 ....*....|.
gi 207028673 109 DYVDLYLIHFP 119
Cdd:cd19080  113 DYIDLLYVHAW 123
AKR_AKR9C1 cd19081
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...
 42-119 3.38e-08

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).


Pssm-ID: 381307 [Multi-domain]  Cd Length: 308  Bit Score: 50.68  E-value: 3.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  42 IEAGFHHIDSAHVYNN----------EEQVGLAIRSkiadgSVKREDIFYTSKL--WSNSHRPEL----VRPALERSLKN 105
Cdd:cd19081   36 VDAGGNFIDTADVYSAwvpgnaggesETIIGRWLKS-----RGKRDRVVIATKVgfPMGPNGPGLsrkhIRRAVEASLRR 110

                         90
                 ....*....|....
gi 207028673 106 LQLDYVDLYLIHFP 119
Cdd:cd19081  111 LQTDYIDLYQAHWD 124
AKR_AKR6B1 cd19142
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ...
 17-117 8.23e-08

AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.


Pssm-ID: 381368 [Multi-domain]  Cd Length: 325  Bit Score: 49.38  E-value: 8.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGTYA--PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgSVKREDIFYTSKL-WSNsh 90
Cdd:cd19142   14 SNVGLGTWStfSTAISEEQAEEIVTLAYENGINYFDTSDAFTSgqaETELGRILKKK----GWKRSSYIVSTKIyWSY-- 87

                         90       100       110
                 ....*....|....*....|....*....|....
gi 207028673  91 RPE---LVRP----ALERSLKNLQLDYVDLYLIH 117
Cdd:cd19142   88 GSEergLSRKhiieSVRASLRRLQLDYIDIVIIH 121
AKR_unchar cd19097
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 29-117 8.54e-08

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381323 [Multi-domain]  Cd Length: 267  Bit Score: 49.45  E-value: 8.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  29 VPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVglairskIADGSVKREDIFYTSKL----WSNSHRPELVRPALERSLK 104
Cdd:cd19097   23 PSEKEAKKILEYALKAGINTLDTAPAYGDSEKV-------LGKFLKRLDKFKIITKLpplkEDKKEDEAAIEASVEASLK 95

                         90
                 ....*....|...
gi 207028673 105 NLQLDYVDLYLIH 117
Cdd:cd19097   96 RLKVDSLDGLLLH 108
AKR_galDH cd19163
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ...
 16-117 9.58e-08

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).


Pssm-ID: 381389 [Multi-domain]  Cd Length: 293  Bit Score: 49.09  E-value: 9.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  16 MPVLGFGTyAPA-----EVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSkiadgsVKREDIFYTSK--- 84
Cdd:cd19163   13 VSKLGFGA-SPLggvfgPVDEEEAIRTVHEALDSGINYIDTAPWYGQgrsETVLGKALKG------IPRDSYYLATKvgr 85

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 207028673  85 ---LWSNS--HRPELVRPALERSLKNLQLDYVDLYLIH 117
Cdd:cd19163   86 yglDPDKMfdFSAERITKSVEESLKRLGLDYIDIIQVH 123
tas PRK10625
putative aldo-keto reductase; Provisional
 18-119 2.19e-07

putative aldo-keto reductase; Provisional


Pssm-ID: 236727 [Multi-domain]  Cd Length: 346  Bit Score: 48.31  E-value: 2.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  18 VLGFGTYAPAEV-PKSKALEAVKLAIEAGFHHIDSAHVYN----------NEEQVGLAIRSKiadGSvkREDIFYTSKLW 86
Cdd:PRK10625  15 TLGLGTMTFGEQnSEADAHAQLDYAVAQGINLIDVAEMYPvpprpetqglTETYIGNWLAKR---GS--REKLIIASKVS 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 207028673  87 ------SNSHRPEL------VRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:PRK10625  90 gpsrnnDKGIRPNQaldrknIREALHDSLKRLQTDYLDLYQVHWP 134
AKR_FDH cd19162
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ...
 17-119 4.17e-07

D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381388 [Multi-domain]  Cd Length: 290  Bit Score: 47.35  E-value: 4.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGTYA---PAEVPKSKALEAVKLAIEAGFHHIDSAHVYN---NEEQVGLAIRSKiadgsvKREDIFYTSKL----- 85
Cdd:cd19162    1 PRLGLGAASlgnLARAGEDEAAATLDAAWDAGIRYFDTAPLYGlglSERRLGAALARH------PRAEYVVSTKVgrlle 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 207028673  86 -----WSNSHRPEL------VRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19162   75 pgaagRPAGADRRFdfsadgIRRSIEASLERLGLDRLDLVFLHDP 119
AKR_AKR15A cd19152
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ...
 17-117 4.29e-07

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381378 [Multi-domain]  Cd Length: 308  Bit Score: 47.22  E-value: 4.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  17 PVLGFGTyAP-----AEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgsvKREDIFYTSKL--- 85
Cdd:cd19152    1 PKLGFGT-APlgnlyEAVSDEEAKATLVAAWDLGIRYFDTAPWYGAglsEERLGAALREL------GREDYVISTKVgrl 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 207028673  86 ---------------WSNS-HRPEL------VRPALERSLKNLQLDYVDLYLIH 117
Cdd:cd19152   74 lvplqeveptfepgfWNPLpFDAVFdysydgILRSIEDSLQRLGLSRIDLLSIH 127
AKR_ARA2 cd19164
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ...
 18-117 1.60e-06

D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381390 [Multi-domain]  Cd Length: 298  Bit Score: 45.73  E-value: 1.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  18 VLGFGTYAPA---EVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQV-GLAIrSKIADgSVKREDIFYTSK-----LWSN 88
Cdd:cd19164   17 IFGAATFSYQyttDPESIPPVDIVRRALELGIRAFDTSPYYGPSEIIlGRAL-KALRD-EFPRDTYFIITKvgrygPDDF 94

                         90       100
                 ....*....|....*....|....*....
gi 207028673  89 SHRPELVRPALERSLKNLQLDYVDLYLIH 117
Cdd:cd19164   95 DYSPEWIRASVERSLRRLHTDYLDLVYLH 123
AKR_unchar cd19103
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 36-123 2.34e-06

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381329 [Multi-domain]  Cd Length: 299  Bit Score: 45.40  E-value: 2.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  36 EAVKLAIEAGFHHIDSAHVYnneeqvGLAIRSKIAdGSV----KREDIF----YTSKLWSNSHRPelVRPALERSLKNLQ 107
Cdd:cd19103   36 AVFDKAMAAGLNLWDTAAVY------GMGASEKIL-GEFlkryPREDYIistkFTPQIAGQSADP--VADMLEGSLARLG 106

                         90
                 ....*....|....*.
gi 207028673 108 LDYVDLYLIHFPVSVK 123
Cdd:cd19103  107 TDYIDIYWIHNPADVE 122
AKR_Tas-like cd19094
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...
 31-119 6.65e-06

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.


Pssm-ID: 381320 [Multi-domain]  Cd Length: 328  Bit Score: 44.09  E-value: 6.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  31 KSKALEAVKLAIEAGFHHIDSAHVY-----------------------NNEEQVGLAirSKIADGSvkrEDIFYTSKLWS 87
Cdd:cd19094   17 EAEAHEQLDYAFDEGVNFIDTAEMYpvppspetqgrteeiigswlkkkGNRDKVVLA--TKVAGPG---EGITWPRGGGT 91

                         90       100       110
                 ....*....|....*....|....*....|..
gi 207028673  88 NsHRPELVRPALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19094   92 R-LDRENIREAVEGSLKRLGTDYIDLYQLHWP 122
AKR_galDH-like cd19153
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ...
 20-117 7.26e-06

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381379 [Multi-domain]  Cd Length: 294  Bit Score: 44.06  E-value: 7.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  20 GFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgSVKREDIFYTSKL-----WSNSHR 91
Cdd:cd19153   21 ALGGVYGDGLEQDEAVAIVAEAFAAGINHFDTSPYYGAessEAVLGKALAAL----QVPRSSYTVATKVgryrdSEFDYS 96

                         90       100
                 ....*....|....*....|....*.
gi 207028673  92 PELVRPALERSLKNLQLDYVDLYLIH 117
Cdd:cd19153   97 AERVRASVATSLERLHTTYLDVVYLH 122
AKR_AKR14A1_2 cd19089
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ...
 20-117 2.63e-05

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.


Pssm-ID: 381315 [Multi-domain]  Cd Length: 308  Bit Score: 42.24  E-value: 2.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  20 GFGTYAPAEVpkskALEAVKLAIEAGFHHIDSAhvyNN--------EEQVGLAIRSkiaDGSVKREDIFYTSK----LW- 86
Cdd:cd19089   21 NFGDYTSPEE----ARELLRTAFDLGITHFDLA---NNygpppgsaEENFGRILKR---DLRPYRDELVISTKagygMWp 90

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 207028673  87 ----SNSHRPELVRpALERSLKNLQLDYVDLYLIH 117
Cdd:cd19089   91 gpygDGGSRKYLLA-SLDQSLKRMGLDYVDIFYHH 124
Aldo_ket_red_shaker cd19141
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ...
 18-119 4.03e-05

Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381367 [Multi-domain]  Cd Length: 310  Bit Score: 41.66  E-value: 4.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  18 VLGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgSVKREDIFYTSKL-WSNSHR 91
Cdd:cd19141   14 CLGLGTWVTfgSQISDEVAEELVTLAYENGINLFDTAEVYaagKAEIVLGKILKKK----GWRRSSYVITTKIfWGGKAE 89

                         90       100       110
                 ....*....|....*....|....*....|....
gi 207028673  92 PE--LVRP----ALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19141   90 TErgLSRKhiieGLKASLERLQLEYVDIVFANRP 123
AKR_unchar cd19752
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 42-117 6.21e-05

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381391 [Multi-domain]  Cd Length: 291  Bit Score: 41.16  E-value: 6.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  42 IEAGFHHIDSAHVYN----------NEEQVG--LAIRSKiadgsvkREDIFYTSKL---------WSNSHR---PELVRP 97
Cdd:cd19752   27 VAAGGNFLDTANNYAfwteggvggeSERLIGrwLKDRGN-------RDDVVIATKVgagprdpdgGPESPEglsAETIEQ 99

                         90       100
                 ....*....|....*....|
gi 207028673  98 ALERSLKNLQLDYVDLYLIH 117
Cdd:cd19752  100 EIDKSLRRLGTDYIDLYYAH 119
AKR_AKR9A1-2 cd19146
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ...
 23-124 7.28e-04

Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.


Pssm-ID: 381372 [Multi-domain]  Cd Length: 326  Bit Score: 38.17  E-value: 7.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  23 TYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ---VG-----------LAIRSKIADGSVKREDIFYTSKLWSN 88
Cdd:cd19146   26 KSMMGECDKETAFKLLDAFYEQGGNFIDTANNYQGEESerwVGewmasrgnrdeMVLATKYTTGYRRGGPIKIKSNYQGN 105

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 207028673  89 sHRPELvRPALERSLKNLQLDYVDLYLIH---FPVSVKE 124
Cdd:cd19146  106 -HAKSL-RLSVEASLKKLQTSYIDILYVHwwdYTTSIPE 142
AKR_KCAB3B_AKR6A9-like cd19160
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ...
 19-113 1.57e-03

voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.


Pssm-ID: 381386 [Multi-domain]  Cd Length: 325  Bit Score: 37.27  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  19 LGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgSVKREDIFYTSKLW------- 86
Cdd:cd19160   18 LGLGTWVTfgSQISDETAEDLLTVAYEHGVNLFDTAEVYaagKAERTLGNILKSK----GWRRSSYVVTTKIYwggqaet 93

                         90       100       110
                 ....*....|....*....|....*....|.
gi 207028673  87 ----SNSHRPELVRPALERslknLQLDYVDL 113
Cdd:cd19160   94 erglSRKHIIEGLRGSLDR----LQLEYVDI 120
AKR_KCAB1B_AKR6A3-like cd19159
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ...
 19-119 1.86e-03

voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.


Pssm-ID: 381385 [Multi-domain]  Cd Length: 323  Bit Score: 36.94  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  19 LGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKiadgSVKREDIFYTSKL-WSNSHRP 92
Cdd:cd19159   16 LGLGTWVTfgGQISDEVAERLMTIAYESGVNLFDTAEVYaagKAEVILGSIIKKK----GWRRSSLVITTKLyWGGKAET 91

                         90       100       110
                 ....*....|....*....|....*....|...
gi 207028673  93 E--LVRP----ALERSLKNLQLDYVDLYLIHFP 119
Cdd:cd19159   92 ErgLSRKhiieGLKGSLQRLQLEYVDVVFANRP 124
PLN02587 PLN02587
L-galactose dehydrogenase
 18-117 3.15e-03

L-galactose dehydrogenase


Pssm-ID: 178198 [Multi-domain]  Cd Length: 314  Bit Score: 36.29  E-value: 3.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207028673  18 VLGFGTyAP-----AEVPKSKALEAVKLAIEAGFHHIDSAHVYNN---EEQVGLAIRSKiadgSVKREDIFYTSKLWSNS 89
Cdd:PLN02587  13 SVGFGA-SPlgsvfGPVSEEDAIASVREAFRLGINFFDTSPYYGGtlsEKVLGKALKAL----GIPREKYVVSTKCGRYG 87

                         90       100       110
                 ....*....|....*....|....*....|..
gi 207028673  90 H----RPELVRPALERSLKNLQLDYVDLYLIH 117
Cdd:PLN02587  88 EgfdfSAERVTKSVDESLARLQLDYVDILHCH 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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