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Conserved domains on  [gi|207029415|ref|NP_001128727|]
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histone-binding protein RBBP4 isoform b [Homo sapiens]

Protein Classification

WD repeat RBAP46/RBAP48/MSI1 family protein( domain architecture ID 13780222)

WD repeat RBAP46/RBAP48/MSI1 family protein binds histones, similar to human histone-binding proteins RBBP4 and RBBP7

Gene Ontology:  GO:0005515|GO:0042393
PubMed:  10322433
SCOP:  4005630

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
121-402 3.60e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 134.38  E-value: 3.60e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 121 NHEGEVNRARYMPQNPCIIATktpSSD--VLVFDYTKhpskpdpsGECnpdLR-LRGHQKEGYGLSWNPNlsGHLL-SAS 196
Cdd:cd00200   49 GHTGPVRDVAASADGTYLASG---SSDktIRLWDLET--------GEC---VRtLTGHTSYVSSVAFSPD--GRILsSSS 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 197 DDHTICLWDIsavpKEGKvvdAKTIFTGHTAVVEDVSWHllHESLFGSVA-DDQKLMIWDTRsnnTSKPSHSVDAHTAEV 275
Cdd:cd00200  113 RDKTIKVWDV----ETGK---CLTTLRGHTDWVNSVAFS--PDGTFVASSsQDGTIKLWDLR---TGKCVATLTGHTGEV 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 276 NCLSFNPySEFILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNEtILASSGTDRRLNVWDLSKigeeqsp 355
Cdd:cd00200  181 NSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRT------- 250
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 207029415 356 edaedgpPELLFIHGGHTAKISDFSWNPNEPWViCSVSEDNIMQVWQ 402
Cdd:cd00200  251 -------GECVQTLSGHTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
18-87 2.90e-33

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


:

Pssm-ID: 463513  Cd Length: 69  Bit Score: 119.22  E-value: 2.90e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 207029415   18 EEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDvtRPEGKDFSIHRLVLGTHTSD-EQNHLVIASVQLPN 87
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
121-402 3.60e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.38  E-value: 3.60e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 121 NHEGEVNRARYMPQNPCIIATktpSSD--VLVFDYTKhpskpdpsGECnpdLR-LRGHQKEGYGLSWNPNlsGHLL-SAS 196
Cdd:cd00200   49 GHTGPVRDVAASADGTYLASG---SSDktIRLWDLET--------GEC---VRtLTGHTSYVSSVAFSPD--GRILsSSS 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 197 DDHTICLWDIsavpKEGKvvdAKTIFTGHTAVVEDVSWHllHESLFGSVA-DDQKLMIWDTRsnnTSKPSHSVDAHTAEV 275
Cdd:cd00200  113 RDKTIKVWDV----ETGK---CLTTLRGHTDWVNSVAFS--PDGTFVASSsQDGTIKLWDLR---TGKCVATLTGHTGEV 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 276 NCLSFNPySEFILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNEtILASSGTDRRLNVWDLSKigeeqsp 355
Cdd:cd00200  181 NSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRT------- 250
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 207029415 356 edaedgpPELLFIHGGHTAKISDFSWNPNEPWViCSVSEDNIMQVWQ 402
Cdd:cd00200  251 -------GECVQTLSGHTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
171-404 3.46e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.27  E-value: 3.46e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 171 RLRGHQKEGYGLSWNPNlsGHLL-SASDDHTICLWDIsavpKEGKVVdakTIFTGHTAVVEDVSWHLlHESLFGSVADDQ 249
Cdd:COG2319  157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDL----ATGKLL---RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 250 KLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 329
Cdd:COG2319  227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 207029415 330 TILASSGTDRRLNVWDLSKigeeqspedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 404
Cdd:COG2319  301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
18-87 2.90e-33

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


Pssm-ID: 463513  Cd Length: 69  Bit Score: 119.22  E-value: 2.90e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 207029415   18 EEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDvtRPEGKDFSIHRLVLGTHTSD-EQNHLVIASVQLPN 87
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
168-347 9.49e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.95  E-value: 9.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 168 PDLRLRGHQKEGyGLSWNPNLSGHLLSASDDHTICLWDISavpKEGKVVDAKTiftgHTAVVEDVSWHLLHESLFGSVAD 247
Cdd:PLN00181 525 PVVELASRSKLS-GICWNSYIKSQVASSNFEGVVQVWDVA---RSQLVTEMKE----HEKRVWSIDYSSADPTLLASGSD 596
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 248 DQKLMIWDTR---SNNTSKPShsvdahtAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW 324
Cdd:PLN00181 597 DGSVKLWSINqgvSIGTIKTK-------ANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF 669
                        170       180
                 ....*....|....*....|...
gi 207029415 325 SphNETILASSGTDRRLNVWDLS 347
Cdd:PLN00181 670 V--DSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
261-301 3.69e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 3.69e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 207029415   261 TSKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 301
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
262-301 2.46e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.46e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 207029415  262 SKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 301
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
121-402 3.60e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.38  E-value: 3.60e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 121 NHEGEVNRARYMPQNPCIIATktpSSD--VLVFDYTKhpskpdpsGECnpdLR-LRGHQKEGYGLSWNPNlsGHLL-SAS 196
Cdd:cd00200   49 GHTGPVRDVAASADGTYLASG---SSDktIRLWDLET--------GEC---VRtLTGHTSYVSSVAFSPD--GRILsSSS 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 197 DDHTICLWDIsavpKEGKvvdAKTIFTGHTAVVEDVSWHllHESLFGSVA-DDQKLMIWDTRsnnTSKPSHSVDAHTAEV 275
Cdd:cd00200  113 RDKTIKVWDV----ETGK---CLTTLRGHTDWVNSVAFS--PDGTFVASSsQDGTIKLWDLR---TGKCVATLTGHTGEV 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 276 NCLSFNPySEFILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNEtILASSGTDRRLNVWDLSKigeeqsp 355
Cdd:cd00200  181 NSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRT------- 250
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 207029415 356 edaedgpPELLFIHGGHTAKISDFSWNPNEPWViCSVSEDNIMQVWQ 402
Cdd:cd00200  251 -------GECVQTLSGHTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
171-404 3.46e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.27  E-value: 3.46e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 171 RLRGHQKEGYGLSWNPNlsGHLL-SASDDHTICLWDIsavpKEGKVVdakTIFTGHTAVVEDVSWHLlHESLFGSVADDQ 249
Cdd:COG2319  157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDL----ATGKLL---RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 250 KLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 329
Cdd:COG2319  227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 207029415 330 TILASSGTDRRLNVWDLSKigeeqspedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 404
Cdd:COG2319  301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
122-403 8.50e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.53  E-value: 8.50e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 122 HEGEVNRARYMPQNPcIIATKTPSSDVLVFDYTkhpskpdpsgECNPDLRLRGHQKEGYGLSWNPNlSGHLLSASDDHTI 201
Cdd:cd00200    8 HTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLE----------TGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 202 CLWDISAvpkeGKVVdakTIFTGHTAVVEDVSWHLLHESLFGSvADDQKLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFN 281
Cdd:cd00200   76 RLWDLET----GECV---RTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKVWDVE---TGKCLTTLRGHTDWVNSVAFS 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 282 PYSEFIlATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNETILASSGtDRRLNVWDLSKigeeqspedaedg 361
Cdd:cd00200  145 PDGTFV-ASSSQDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLST------------- 208
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 207029415 362 pPELLFIHGGHTAKISDFSWNPNEPWvICSVSEDNIMQVWQM 403
Cdd:cd00200  209 -GKCLGTLRGHENGVNSVAFSPDGYL-LASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
171-404 9.73e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 9.73e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 171 RLRGHQKEGYGLSWNPNlSGHLLSASDDHTICLWDIsavpKEGKVVdakTIFTGHTAVVEDVSWHLLHESLFgSVADDQK 250
Cdd:COG2319  115 TLTGHTGAVRSVAFSPD-GKTLASGSADGTVRLWDL----ATGKLL---RTLTGHSGAVTSVAFSPDGKLLA-SGSDDGT 185
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 251 LMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNET 330
Cdd:COG2319  186 VRLWDLA---TGKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSP-DGR 259
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 207029415 331 ILASSGTDRRLNVWDLSkigeeqspedaedgPPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 404
Cdd:COG2319  260 LLASGSADGTVRLWDLA--------------TGELLRTLTGHSGGVNSVAFSPDGKLLA-SGSDDGTVRLWDLA 318
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
18-87 2.90e-33

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


Pssm-ID: 463513  Cd Length: 69  Bit Score: 119.22  E-value: 2.90e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 207029415   18 EEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDvtRPEGKDFSIHRLVLGTHTSD-EQNHLVIASVQLPN 87
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
172-405 2.43e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.98  E-value: 2.43e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 172 LRGHQKEGYGLSWNPNlSGHLLSASDDHTICLWDIsavpkegKVVDAKTIFTGHTAVVEDVSWHLLHESLFgSVADDQKL 251
Cdd:cd00200    5 LKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDL-------ETGELLRTLKGHTGPVRDVAASADGTYLA-SGSSDKTI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 252 MIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPySEFILATGSADKTVALWDLRNLKLKlHSFESHKDEIFQVQWSPHNeTI 331
Cdd:cd00200   76 RLWDL---ETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCL-TTLRGHTDWVNSVAFSPDG-TF 149
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 207029415 332 LASSGTDRRLNVWDLSKIGEEQSpedaedgppellfiHGGHTAKISDFSWNPNEPWVICSvSEDNIMQVWQMAE 405
Cdd:cd00200  150 VASSSQDGTIKLWDLRTGKCVAT--------------LTGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
171-347 2.79e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 2.79e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 171 RLRGHQKEGYGLSWNPNlSGHLLSASDDHTICLWDISavpkEGKVVdakTIFTGHTAVVEDVSWHLLHESLFgSVADDQK 250
Cdd:COG2319  241 TLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLA----TGELL---RTLTGHSGGVNSVAFSPDGKLLA-SGSDDGT 311
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 251 LMIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNET 330
Cdd:COG2319  312 VRLWDL---ATGKLLRTLTGHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGEL-LRTLTGHTGAVTSVAFSP-DGR 385
                        170
                 ....*....|....*..
gi 207029415 331 ILASSGTDRRLNVWDLS 347
Cdd:COG2319  386 TLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
170-404 9.97e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 9.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 170 LRLRGHQKEGYGLSWNPnLSGHLLSASDDHTICLWDISAVPkegkvvdAKTIFTGHTAVVEDVSWHLLHESLfGSVADDQ 249
Cdd:COG2319   30 LLLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGA-------LLATLLGHTAAVLSVAFSPDGRLL-ASASADG 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 250 KLMIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPySEFILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 329
Cdd:COG2319  101 TVRLWDL---ATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKL-LRTLTGHSGAVTSVAFSP-DG 174
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 207029415 330 TILASSGTDRRLNVWDLSKigeeqspedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 404
Cdd:COG2319  175 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
264-404 3.41e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 3.41e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 264 PSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNETiLASSGTDRRLNV 343
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGEL-LRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRL 77
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 207029415 344 WDLSKigeeqspedaedgpPELLFIHGGHTAKISDFSWNPNEPWVICSvSEDNIMQVWQMA 404
Cdd:cd00200   78 WDLET--------------GECVRTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
171-304 3.39e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 3.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 171 RLRGHQKEGYGLSWNPNlSGHLLSASDDHTICLWDISavpkEGKVVdakTIFTGHTAVVEDVSWHLLHESLFgSVADDQK 250
Cdd:COG2319  283 TLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLA----TGKLL---RTLTGHTGAVRSVAFSPDGKTLA-SGSDDGT 353
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 207029415 251 LMIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRN 304
Cdd:COG2319  354 VRLWDL---ATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
168-347 9.49e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.95  E-value: 9.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 168 PDLRLRGHQKEGyGLSWNPNLSGHLLSASDDHTICLWDISavpKEGKVVDAKTiftgHTAVVEDVSWHLLHESLFGSVAD 247
Cdd:PLN00181 525 PVVELASRSKLS-GICWNSYIKSQVASSNFEGVVQVWDVA---RSQLVTEMKE----HEKRVWSIDYSSADPTLLASGSD 596
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 248 DQKLMIWDTR---SNNTSKPShsvdahtAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW 324
Cdd:PLN00181 597 DGSVKLWSINqgvSIGTIKTK-------ANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF 669
                        170       180
                 ....*....|....*....|...
gi 207029415 325 SphNETILASSGTDRRLNVWDLS 347
Cdd:PLN00181 670 V--DSSTLVSSSTDNTLKLWDLS 690
PTZ00420 PTZ00420
coronin; Provisional
264-346 2.95e-10

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 61.89  E-value: 2.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 264 PSHSVDAHTAEVNCLSFNP-YSEfILATGSADKTVALWDLRN-------LKLKLHSFESHKDEIFQVQWSPHNETILASS 335
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPcFSE-ILASGSEDLTIRVWEIPHndesvkeIKDPQCILKGHKKKISIIDWNPMNYYIMCSS 144
                         90
                 ....*....|.
gi 207029415 336 GTDRRLNVWDL 346
Cdd:PTZ00420 145 GFDSFVNIWDI 155
PTZ00420 PTZ00420
coronin; Provisional
160-306 5.13e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.96  E-value: 5.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 160 PDPSGECNPDLRLRGHQKEGYGLSwnpnlsghllsASDDHTICLWD------ISAVPKEGKVVDAKTI-FTGHTAVVEDV 232
Cdd:PTZ00420  12 PDPSNNLFDDLRICSRVIDSCGIA-----------CSSGFVAVPWEveggglIGAIRLENQMRKPPVIkLKGHTSSILDL 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 207029415 233 SWHLLHESLFGSVADDQKLMIWDTRSNNTS-----KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 306
Cdd:PTZ00420  81 QFNPCFSEILASGSEDLTIRVWEIPHNDESvkeikDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
PTZ00421 PTZ00421
coronin; Provisional
167-357 1.44e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.36  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 167 NPDLRLrGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDIsavPKEG---KVVDAKTIFTGHTAVVEDVSWHLLHESLFG 243
Cdd:PTZ00421  67 NPPILL-GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGI---PEEGltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLA 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 244 SVADDQKLMIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQ-V 322
Cdd:PTZ00421 143 SAGADMVVNVWDV---ERGKAVEVIKCHSDQITSLEWNLDGS-LLCTTSKDKKLNIIDPRDGTI-VSSVEAHASAKSQrC 217
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 207029415 323 QWSPHNETILA---SSGTDRRLNVWDLSKIGEEQSPED 357
Cdd:PTZ00421 218 LWAKRKDLIITlgcSKSQQRQIMLWDTRKMASPYSTVD 255
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
261-301 3.69e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 3.69e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 207029415   261 TSKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 301
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
305-406 4.95e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 51.87  E-value: 4.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 305 LKLKlhsfeSHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKigEEQSPEDAEDGppelLFIHGGHTAKISDFSWNPN 384
Cdd:PTZ00420  68 IKLK-----GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPH--NDESVKEIKDP----QCILKGHKKKISIIDWNPM 136
                         90       100
                 ....*....|....*....|..
gi 207029415 385 EPWVICSVSEDNIMQVWQMaEN 406
Cdd:PTZ00420 137 NYYIMCSSGFDSFVNIWDI-EN 157
PTZ00421 PTZ00421
coronin; Provisional
213-345 1.39e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.28  E-value: 1.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207029415 213 GKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTR----SNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL 288
Cdd:PTZ00421  62 GKLASNPPILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMNVL 141
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 207029415 289 ATGSADKTVALWDLRNLKLKlHSFESHKDEIFQVQWSPHNeTILASSGTDRRLNVWD 345
Cdd:PTZ00421 142 ASAGADMVVNVWDVERGKAV-EVIKCHSDQITSLEWNLDG-SLLCTTSKDKKLNIID 196
WD40 pfam00400
WD domain, G-beta repeat;
262-301 2.46e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.46e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 207029415  262 SKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 301
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
172-205 5.72e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 207029415   172 LRGHQKEGYGLSWNPNlSGHLLSASDDHTICLWD 205
Cdd:smart00320   8 LKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
309-345 7.17e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 7.17e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 207029415   309 LHSFESHKDEIFQVQWSPHNeTILASSGTDRRLNVWD 345
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
309-345 5.63e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 5.63e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 207029415  309 LHSFESHKDEIFQVQWSPhNETILASSGTDRRLNVWD 345
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
172-205 1.10e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 207029415  172 LRGHQKEGYGLSWNPNlSGHLLSASDDHTICLWD 205
Cdd:pfam00400   7 LEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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