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Conserved domains on  [gi|218505690|ref|NP_001136201|]
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leucine-rich repeat-containing protein 9 isoform 3 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 53-236 1.95e-32

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 124.90  E-value: 1.95e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690  53 FHNLSSLTIVAQDIREISGLETCLQLKELWIAECCIEKIEGLQGCRNLEKLYLYYNKISKIENLEKLIKLEVLWLNHNMI 132
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690 133 KNIEGLQTLKNLKDL------------------------------NLAGNLVSSIgRCLDPNEQLEKLNLSGNQITSFKD 182
Cdd:cd21340   81 SVVEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEE 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 218505690 183 LTN-LTKLTRLKDLCLNDpqyksNPVCQLCNYSTHVLYHLPSLQRLDTFDVSAKQ 236
Cdd:cd21340  160 LLDlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 53-236 1.95e-32

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 124.90  E-value: 1.95e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690  53 FHNLSSLTIVAQDIREISGLETCLQLKELWIAECCIEKIEGLQGCRNLEKLYLYYNKISKIENLEKLIKLEVLWLNHNMI 132
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690 133 KNIEGLQTLKNLKDL------------------------------NLAGNLVSSIgRCLDPNEQLEKLNLSGNQITSFKD 182
Cdd:cd21340   81 SVVEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEE 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 218505690 183 LTN-LTKLTRLKDLCLNDpqyksNPVCQLCNYSTHVLYHLPSLQRLDTFDVSAKQ 236
Cdd:cd21340  160 LLDlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-195 1.13e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.43  E-value: 1.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690  35 SKLEMFFSGYPRIVGLSLFHN-LSSLTIvaqdirEISGLEtclQLKELWIAECCIEKI-EGLQGCRNLEKLYLYYNKISK 112
Cdd:COG4886  172 TDLPEELGNLTNLKELDLSNNqITDLPE------PLGNLT---NLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTD 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690 113 IENLEKLIKLEVLWLNHNMIKNIEGLQTLKNLKDLNLAGNLVSSIG-RCLDPNEQLEKLNLSGNQITSFKDLTNLTKLTR 191
Cdd:COG4886  243 LPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322


                 ....
gi 218505690 192 LKDL 195
Cdd:COG4886  323 LLLL 326
LRR_9 pfam14580
Leucine-rich repeat;
108-242 1.19e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 57.85  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690  108 NKISKIENL-EKLIKLEVLWLNHNMIKNIEGLQTLKNLKDLNLAGNLVSSIGRCLD---PNeqLEKLNLSGNQITSFKDL 183
Cdd:pfam14580  29 YKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGealPN--LTELILTNNNLQELGDL 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 218505690  184 TNLTKLTRLKDLCLNDpqyksNPVCQLCNYSTHVLYHLPSLQRLDTFDVSAKQIKELAD 242
Cdd:pfam14580 107 DPLASLKKLTFLSLLR-----NPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 53-236 1.95e-32

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 124.90  E-value: 1.95e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690  53 FHNLSSLTIVAQDIREISGLETCLQLKELWIAECCIEKIEGLQGCRNLEKLYLYYNKISKIENLEKLIKLEVLWLNHNMI 132
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690 133 KNIEGLQTLKNLKDL------------------------------NLAGNLVSSIgRCLDPNEQLEKLNLSGNQITSFKD 182
Cdd:cd21340   81 SVVEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEE 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 218505690 183 LTN-LTKLTRLKDLCLNDpqyksNPVCQLCNYSTHVLYHLPSLQRLDTFDVSAKQ 236
Cdd:cd21340  160 LLDlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 47-179 3.86e-20

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 89.46  E-value: 3.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690  47 IVGLSLFHNLSslTIVAQD--IREISGLETCLQLKELWIAECCIEKIEGLQGCRNLEKLYLYYNKISKIENLEKLIKLE- 123
Cdd:cd21340   17 IDNLSLCKNLK--VLYLYDnkITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEe 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690 124 -----------------------------VLWLNHNMIKNIEGLQTLKNLKDLNLAGNLVSSIGRCLDP---NEQLEKLN 171
Cdd:cd21340   95 lhienqrlppgekltfdprslaalsnslrVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLlssWPSLRELD 174


                 ....*...
gi 218505690 172 LSGNQITS 179
Cdd:cd21340  175 LTGNPVCK 182
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-195 1.13e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.43  E-value: 1.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690  35 SKLEMFFSGYPRIVGLSLFHN-LSSLTIvaqdirEISGLEtclQLKELWIAECCIEKI-EGLQGCRNLEKLYLYYNKISK 112
Cdd:COG4886  172 TDLPEELGNLTNLKELDLSNNqITDLPE------PLGNLT---NLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTD 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690 113 IENLEKLIKLEVLWLNHNMIKNIEGLQTLKNLKDLNLAGNLVSSIG-RCLDPNEQLEKLNLSGNQITSFKDLTNLTKLTR 191
Cdd:COG4886  243 LPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322


                 ....
gi 218505690 192 LKDL 195
Cdd:COG4886  323 LLLL 326
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-282 1.29e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 1.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690  50 LSLFHNLSSLTIVAQDIREISGLETCLQLKELWIAECCIEKIEGLQGCRNLEKLYLYYNKISKIENLEKLIKLEVLWLNH 129
Cdd:COG4886   26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690 130 NmikniEGLQTLKNLKDLNLAGNLVSSIGRCLDPNEQLEKLNLSGNQITSF-KDLTNLTKLTRLkDLclndpqyKSNPVC 208
Cdd:COG4886  106 N-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSL-DL-------SNNQLT 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690 209 QLcnysTHVLYHLPSLQRLdtfDVSAKQIKELADS----TAMKKIMYYNMRIKTVQRHLNE--ELEKLNDRKCKLQKLPE 282
Cdd:COG4886  173 DL----PEELGNLTNLKEL---DLSNNQITDLPEPlgnlTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE 245
LRR_9 pfam14580
Leucine-rich repeat;
108-242 1.19e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 57.85  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690  108 NKISKIENL-EKLIKLEVLWLNHNMIKNIEGLQTLKNLKDLNLAGNLVSSIGRCLD---PNeqLEKLNLSGNQITSFKDL 183
Cdd:pfam14580  29 YKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGealPN--LTELILTNNNLQELGDL 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 218505690  184 TNLTKLTRLKDLCLNDpqyksNPVCQLCNYSTHVLYHLPSLQRLDTFDVSAKQIKELAD 242
Cdd:pfam14580 107 DPLASLKKLTFLSLLR-----NPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 99-138 1.11e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 45.70  E-value: 1.11e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 218505690   99 NLEKLYLYYNKISKIENLEKLIKLEVLWLNHN-MIKNIEGL 138
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDL 42
LRR_8 pfam13855
Leucine rich repeat;
121-177 2.02e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 2.02e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690  121 KLEVLWLNHNMIKNIEG--LQTLKNLKDLNLAGNLVSSI-GRCLDPNEQLEKLNLSGNQI 177
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 69-201 3.72e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.79  E-value: 3.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690  69 ISGLETCLQLKELWI------AECCIEKIEGLQGCRNLEKLYLYYNKISkienlekliklevlwlNHNMIKNIEGLQTLK 142
Cdd:COG5238  285 AKALQGNTTLTSLDLsvnrigDEGAIALAEGLQGNKTLHTLNLAYNGIG----------------AQGAIALAKALQENT 348

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 218505690 143 NLKDLNLAGNLVS-----SIGRCLDPNEQLEKLNLSGNQITS--FKDLTNLTKLTRLKDLCLNDPQ 201
Cdd:COG5238  349 TLHSLDLSDNQIGdegaiALAKYLEGNTTLRELNLGKNNIGKqgAEALIDALQTNRLHTLILDGNL 414
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 121-152 1.59e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.23  E-value: 1.59e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 218505690  121 KLEVLWLNHNMIKNIEGLQTLKNLKDLNLAGN 152
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 77-118 1.61e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 1.61e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 218505690   77 QLKELWIAECCIEKIEGLQGCRNLEKLYLYYN-KISKIENLEK 118
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-178 2.10e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690  84 AECCIEKIEGLQGCRNLEKLYLYYNKISK------IENLEKLIKLEVLWLNHNMIKNI------EGLQTLKNLKDLNLAG 151
Cdd:cd00116  151 GASCEALAKALRANRDLKELNLANNGIGDagiralAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGD 230

                         90       100       110
                 ....*....|....*....|....*....|...
gi 218505690 152 NLVSSIGRC------LDPNEQLEKLNLSGNQIT 178
Cdd:cd00116  231 NNLTDAGAAalasalLSPNISLLTLSLSCNDIT 263
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 20-199 7.92e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.47  E-value: 7.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690  20 NGLTYEIVGQEGSDTSK--LEMFFSGYPRIVGLSLFHNLssLTIVAQDIREISGLETCLQlkelwiaecCIEKIEGLQGc 97
Cdd:COG5238  112 VATPPPDLRRIMAKTLEdsLILYLALPRRINLIQVLKDP--LGGNAVHLLGLAARLGLLA---------AISMAKALQN- 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505690  98 RNLEKLYLYYNKISKiENLEKLIK-------LEVLWLNHNMIKN------IEGLQTLKNLKDLNLAGNL-----VSSIGR 159
Cdd:COG5238  180 NSVETVYLGCNQIGD-EGIEELAEaltqnttVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQigdegVIALAE 258

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 218505690 160 CLDPNEQLEKLNLSGNQIT---------SFKDLTNLTKLtrlkDLCLND 199
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGaegaialakALQGNTTLTSL----DLSVNR 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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