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Conserved domains on  [gi|219555702|ref|NP_001137230|]
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leucine-rich repeat-containing protein 27 isoform b [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-155 1.40e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 1.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555702  49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIK 127
Cdd:COG4886  140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                         90       100
                 ....*....|....*....|....*...
gi 219555702 128 MLPVELGSVTTLKALNLRHCPLEFPPQL 155
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-155 1.40e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 1.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555702  49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIK 127
Cdd:COG4886  140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                         90       100
                 ....*....|....*....|....*...
gi 219555702 128 MLPVELGSVTTLKALNLRHCPLEFPPQL 155
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
LRR_8 pfam13855
Leucine rich repeat;
67-126 4.59e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 4.59e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 219555702   67 PSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAH-QHLKTLLLERNPI 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-146 1.17e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555702  50 LDLSESGLC-RLE-EVFRIPSLQQLHLQRNAlcvipqdFFQLLP------NLTWLDLRYNRIK-ALPSGIGAHQHLKTLL 120
Cdd:PLN00113 433 LDISNNNLQgRINsRKWDMPSLQMLSLARNK-------FFGGLPdsfgskRLENLDLSRNQFSgAVPRKLGSLSELMQLK 505

                         90       100
                 ....*....|....*....|....*..
gi 219555702 121 LERNPIK-MLPVELGSVTTLKALNLRH 146
Cdd:PLN00113 506 LSENKLSgEIPDELSSCKKLVSLDLSH 532
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-129 1.04e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555702  50 LDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQdfFQLLPNLTWLDLRYNRIKALPsGIGAHQHLKTLLLERNPIKML 129
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV 83
LRR smart00370
Leucine-rich repeats, outliers;
90-113 4.65e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 4.65e-03
                           10        20
                   ....*....|....*....|....
gi 219555702    90 LPNLTWLDLRYNRIKALPSGIGAH 113
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-155 1.40e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 1.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555702  49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIK 127
Cdd:COG4886  140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                         90       100
                 ....*....|....*....|....*...
gi 219555702 128 MLPVELGSVTTLKALNLRHCPLEFPPQL 155
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-155 2.53e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 2.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555702  52 LSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPV 131
Cdd:COG4886   98 LTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANL-TNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE 176

                         90       100
                 ....*....|....*....|....*
gi 219555702 132 ELGSVTTLKALNLRHCPL-EFPPQL 155
Cdd:COG4886  177 ELGNLTNLKELDLSNNQItDLPEPL 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-150 1.92e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 1.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555702  50 LDLSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSgIGAHQHLKTLLLERNPIKM 128
Cdd:COG4886  187 LDLSNNQITDLPEPLgNLTNLEELDLSGNQLTDLPEPLANL-TNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTD 264

                         90       100
                 ....*....|....*....|..
gi 219555702 129 LPvELGSVTTLKALNLRHCPLE 150
Cdd:COG4886  265 LP-PLANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-150 8.07e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 8.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555702  50 LDLSESGLCRLEEVFRIPSLQQLHLQRNalcvipqDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKML 129
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                         90       100
                 ....*....|....*....|.
gi 219555702 130 PVELGSVTTLKALNLRHCPLE 150
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLT 172
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-132 2.27e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 2.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555702  50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQdfFQLLPNLTWLDLRYNRIKALPSgIGAHQHLKTLLLERNPIKM 128
Cdd:COG4886  210 LDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTD 286


                 ....
gi 219555702 129 LPVE 132
Cdd:COG4886  287 LKLK 290
LRR_8 pfam13855
Leucine rich repeat;
67-126 4.59e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 4.59e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 219555702   67 PSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAH-QHLKTLLLERNPI 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-146 1.17e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555702  50 LDLSESGLC-RLE-EVFRIPSLQQLHLQRNAlcvipqdFFQLLP------NLTWLDLRYNRIK-ALPSGIGAHQHLKTLL 120
Cdd:PLN00113 433 LDISNNNLQgRINsRKWDMPSLQMLSLARNK-------FFGGLPdsfgskRLENLDLSRNQFSgAVPRKLGSLSELMQLK 505

                         90       100
                 ....*....|....*....|....*..
gi 219555702 121 LERNPIK-MLPVELGSVTTLKALNLRH 146
Cdd:PLN00113 506 LSENKLSgEIPDELSSCKKLVSLDLSH 532
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-106 4.70e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 4.70e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 219555702  49 ILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFqlLPNLTWLDLRYNRIKAL 106
Cdd:COG4886  232 TLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQLTDL 287
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-129 1.04e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555702  50 LDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQdfFQLLPNLTWLDLRYNRIKALPsGIGAHQHLKTLLLERNPIKML 129
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-123 1.20e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 1.20e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 219555702  57 LCRLEEVFRIPSLQQLHLQRNALCVIpqDFFQLLPNLTWLDLRYNRIKALpSGIGAHQHLKTLLLER 123
Cdd:cd21340   36 ITKIENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIEN 99
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 63-144 2.81e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555702  63 VFRIPSLQQLHLQRNALC-VIPQDFFQLLPNLTWLDLRYNRIK-ALPSgiGAHQHLKTLLLERNPIK-MLPVELGSVTTL 139
Cdd:PLN00113  89 IFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIGSFSSL 166


                 ....*
gi 219555702 140 KALNL 144
Cdd:PLN00113 167 KVLDL 171
LRR smart00370
Leucine-rich repeats, outliers;
90-113 4.65e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 4.65e-03
                           10        20
                   ....*....|....*....|....
gi 219555702    90 LPNLTWLDLRYNRIKALPSGIGAH 113
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
90-113 4.65e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 4.65e-03
                           10        20
                   ....*....|....*....|....
gi 219555702    90 LPNLTWLDLRYNRIKALPSGIGAH 113
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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