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Conserved domains on  [gi|219842262|ref|NP_001137359|]
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COP9 signalosome complex subunit 2 isoform 2 [Homo sapiens]

Protein Classification

COP9 signalosome complex subunit 2( domain architecture ID 11854163)

COP9 signalosome complex subunit 2 (CSN2) is a subunit of COP9 signalosome (CSN) which is a highly conserved protein complex that consists of eight subunits known as CSN1 to CSN8 in higher eukaryotes; CSN complex is a general modulator of diverse cellular and developmental processes

Gene Ontology:  GO:0008180|GO:0000338
PubMed:  32708147

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
316-420 1.21e-29

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


:

Pssm-ID: 460195  Cd Length: 105  Bit Score: 111.15  E-value: 1.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262  316 LAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESL 395
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 219842262  396 LVQCILDNTIHGRIDQVNQLLELDH 420
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
RPN6 super family cl26506
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
40-441 1.33e-26

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG5159:

Pssm-ID: 227488 [Multi-domain]  Cd Length: 421  Bit Score: 111.16  E-value: 1.33e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262  40 KALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSA---VTRNYSEKSINSIL 116
Cdd:COG5159   12 NAVKSNDIEKAIGEYKRILGKGVSKDEKTLNEQEATVLELFKLYVSKGDYCSLGDTITSSREAmedFTKPKITKIIRTLI 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262 117 DYISTSKQNsdflcqMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGK-LQKILRQLHQSCQTDDGeddl 195
Cdd:COG5159   92 EKFPYSSDS------LEDQIKVLTALIEWADREKRKFLRLELECKLIYLLYKTGKYSDaLALINPLLHELKKYDDK---- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262 196 kkgTQLLEIYALEIQMYTAQKNNKKLKA-LYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYdE 274
Cdd:COG5159  162 ---INLITVHLLESKVYHEIRNVSKSKAsLTAARTLANSAYCPPQLQAQLDLLSGILHCDDRDYKTASSYFIEALEGF-T 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262 275 SGSPRRTTC--LKYLVLANMLMKSGI---NPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPF 349
Cdd:COG5159  238 LLKMDVKACvsLKYMLLSKIMLNRREevkAVLRNKNTLKHYDDRMIRAMLAVAEAFGNRSLKDFSDALAQYSDELHQDSF 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262 350 IREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYT 429
Cdd:COG5159  318 IRSHLQYLYDVLLEKNLVKIIEPFSVVEISHIADVIGLDTNQVEGKLSQMILDKIFYGTLDQGDGCLIVYGEPAQDNTYD 397
                        410
                 ....*....|..
gi 219842262 430 ALDKWTNQLNSL 441
Cdd:COG5159  398 EALEQVEALDCV 409
 
Name Accession Description Interval E-value
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
316-420 1.21e-29

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 111.15  E-value: 1.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262  316 LAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESL 395
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 219842262  396 LVQCILDNTIHGRIDQVNQLLELDH 420
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
RPN6 COG5159
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
40-441 1.33e-26

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227488 [Multi-domain]  Cd Length: 421  Bit Score: 111.16  E-value: 1.33e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262  40 KALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSA---VTRNYSEKSINSIL 116
Cdd:COG5159   12 NAVKSNDIEKAIGEYKRILGKGVSKDEKTLNEQEATVLELFKLYVSKGDYCSLGDTITSSREAmedFTKPKITKIIRTLI 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262 117 DYISTSKQNsdflcqMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGK-LQKILRQLHQSCQTDDGeddl 195
Cdd:COG5159   92 EKFPYSSDS------LEDQIKVLTALIEWADREKRKFLRLELECKLIYLLYKTGKYSDaLALINPLLHELKKYDDK---- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262 196 kkgTQLLEIYALEIQMYTAQKNNKKLKA-LYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYdE 274
Cdd:COG5159  162 ---INLITVHLLESKVYHEIRNVSKSKAsLTAARTLANSAYCPPQLQAQLDLLSGILHCDDRDYKTASSYFIEALEGF-T 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262 275 SGSPRRTTC--LKYLVLANMLMKSGI---NPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPF 349
Cdd:COG5159  238 LLKMDVKACvsLKYMLLSKIMLNRREevkAVLRNKNTLKHYDDRMIRAMLAVAEAFGNRSLKDFSDALAQYSDELHQDSF 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262 350 IREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYT 429
Cdd:COG5159  318 IRSHLQYLYDVLLEKNLVKIIEPFSVVEISHIADVIGLDTNQVEGKLSQMILDKIFYGTLDQGDGCLIVYGEPAQDNTYD 397
                        410
                 ....*....|..
gi 219842262 430 ALDKWTNQLNSL 441
Cdd:COG5159  398 EALEQVEALDCV 409
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
353-434 6.66e-19

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 81.13  E-value: 6.66e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262   353 HIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDH-----QKRGGAR 427
Cdd:smart00088   2 LVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEvdprrSEPLAQF 81

                   ....*..
gi 219842262   428 YTALDKW 434
Cdd:smart00088  82 AETLKKL 88
 
Name Accession Description Interval E-value
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
316-420 1.21e-29

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 111.15  E-value: 1.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262  316 LAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESL 395
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 219842262  396 LVQCILDNTIHGRIDQVNQLLELDH 420
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
RPN6 COG5159
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
40-441 1.33e-26

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227488 [Multi-domain]  Cd Length: 421  Bit Score: 111.16  E-value: 1.33e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262  40 KALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSA---VTRNYSEKSINSIL 116
Cdd:COG5159   12 NAVKSNDIEKAIGEYKRILGKGVSKDEKTLNEQEATVLELFKLYVSKGDYCSLGDTITSSREAmedFTKPKITKIIRTLI 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262 117 DYISTSKQNsdflcqMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGK-LQKILRQLHQSCQTDDGeddl 195
Cdd:COG5159   92 EKFPYSSDS------LEDQIKVLTALIEWADREKRKFLRLELECKLIYLLYKTGKYSDaLALINPLLHELKKYDDK---- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262 196 kkgTQLLEIYALEIQMYTAQKNNKKLKA-LYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYdE 274
Cdd:COG5159  162 ---INLITVHLLESKVYHEIRNVSKSKAsLTAARTLANSAYCPPQLQAQLDLLSGILHCDDRDYKTASSYFIEALEGF-T 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262 275 SGSPRRTTC--LKYLVLANMLMKSGI---NPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPF 349
Cdd:COG5159  238 LLKMDVKACvsLKYMLLSKIMLNRREevkAVLRNKNTLKHYDDRMIRAMLAVAEAFGNRSLKDFSDALAQYSDELHQDSF 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262 350 IREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYT 429
Cdd:COG5159  318 IRSHLQYLYDVLLEKNLVKIIEPFSVVEISHIADVIGLDTNQVEGKLSQMILDKIFYGTLDQGDGCLIVYGEPAQDNTYD 397
                        410
                 ....*....|..
gi 219842262 430 ALDKWTNQLNSL 441
Cdd:COG5159  398 EALEQVEALDCV 409
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
353-434 6.66e-19

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 81.13  E-value: 6.66e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219842262   353 HIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDH-----QKRGGAR 427
Cdd:smart00088   2 LVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEvdprrSEPLAQF 81

                   ....*..
gi 219842262   428 YTALDKW 434
Cdd:smart00088  82 AETLKKL 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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