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Conserved domains on  [gi|221136866|ref|NP_001137464|]
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telomerase Cajal body protein 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
177-481 1.28e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.13  E-value: 1.28e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 177 WAPDGSCILTNSADNILRIYNLppelyHEGEQveyaemvpvLRMVEGDTIYdycWYSLMSSaqPDTSYVASSSRENPIHI 256
Cdd:COG2319  128 FSPDGKTLASGSADGTVRLWDL-----ATGKL---------LRTLTGHSGA---VTSVAFS--PDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 257 WDAFTGELRASFRAYNHldeltAAHSLCFSPDGSQLFCG-FNRTVRVFSTARPgrdcEVRATFakkQGQSGIISCIAFSP 335
Cdd:COG2319  189 WDLATGKLLRTLTGHTG-----AVRSVAFSPDGKLLASGsADGTVRLWDLATG----KLLRTL---TGHSGSVRSVAFSP 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 336 AQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARkDAELLCWDLrQSGYPLWSLGREVTTNQ 415
Cdd:COG2319  257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD-DGTVRLWDL-ATGKLLRTLTGHTGAVR 334

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221136866 416 RIYFdlDPTGQFLVSGSTSGAVSVWDTDGpgndgkPEPVLSFLPQKDCTNGVSLHPSLPLLATASG 481
Cdd:COG2319  335 SVAF--SPDGKTLASGSDDGTVRLWDLAT------GELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
177-481 1.28e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.13  E-value: 1.28e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 177 WAPDGSCILTNSADNILRIYNLppelyHEGEQveyaemvpvLRMVEGDTIYdycWYSLMSSaqPDTSYVASSSRENPIHI 256
Cdd:COG2319  128 FSPDGKTLASGSADGTVRLWDL-----ATGKL---------LRTLTGHSGA---VTSVAFS--PDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 257 WDAFTGELRASFRAYNHldeltAAHSLCFSPDGSQLFCG-FNRTVRVFSTARPgrdcEVRATFakkQGQSGIISCIAFSP 335
Cdd:COG2319  189 WDLATGKLLRTLTGHTG-----AVRSVAFSPDGKLLASGsADGTVRLWDLATG----KLLRTL---TGHSGSVRSVAFSP 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 336 AQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARkDAELLCWDLrQSGYPLWSLGREVTTNQ 415
Cdd:COG2319  257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD-DGTVRLWDL-ATGKLLRTLTGHTGAVR 334

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221136866 416 RIYFdlDPTGQFLVSGSTSGAVSVWDTDGpgndgkPEPVLSFLPQKDCTNGVSLHPSLPLLATASG 481
Cdd:COG2319  335 SVAF--SPDGKTLASGSDDGTVRLWDLAT------GELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-480 6.78e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 6.78e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 175 CKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVlrmvegdtiydycwyslmsSAQPDTSYVASSSRENPI 254
Cdd:cd00200   15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDV-------------------AASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 255 HIWDAFTGELRASFRAynHLDELTaahSLCFSPDGSQLF-CGFNRTVRVFSTarpgRDCEVRATFakkQGQSGIISCIAF 333
Cdd:cd00200   76 RLWDLETGECVRTLTG--HTSYVS---SVAFSPDGRILSsSSRDKTIKVWDV----ETGKCLTTL---RGHTDWVNSVAF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 334 SPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARkDAELLCWDLRQsgyplwslGREVTT 413
Cdd:cd00200  144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLST--------GKCLGT 214

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221136866 414 ----NQRIYF-DLDPTGQFLVSGSTSGAVSVWDTDgpgnDGKPEPVLSfLPQKDCTnGVSLHPSLPLLATAS 480
Cdd:cd00200  215 lrghENGVNSvAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLS-GHTNSVT-SLAWSPDGKRLASGS 280
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 356-396 3.32e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.32e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 221136866   356 DGSPLALLGGHQGGITHLCFHPDGNRFFSGARkDAELLCWD 396
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSD-DGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
357-396 4.86e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.86e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 221136866  357 GSPLALLGGHQGGITHLCFHPDGNRFFSGARkDAELLCWD 396
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSD-DGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 180-491 2.21e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 2.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 180 DGSCILTNSADNILRIYNLPpELYHEGEQVEYaemvPVLRMVEGDTIYDYCWYSLMSSAqpdtsyVASSSRENPIHIWDA 259
Cdd:PLN00181 494 DGEFFATAGVNKKIKIFECE-SIIKDGRDIHY----PVVELASRSKLSGICWNSYIKSQ------VASSNFEGVVQVWDV 562

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 260 FTGELRASFRAYNHldeltaahslcfspdgsqlfcgfnrtvRVFStarpgrdcevratfakkqgqsgiiscIAFSPAQP- 338
Cdd:PLN00181 563 ARSQLVTEMKEHEK---------------------------RVWS--------------------------IDYSSADPt 589

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 339 LYACGSYGRSLGLYAWDDGSPLALLGGhQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSL-GREVTTNQRI 417
Cdd:PLN00181 590 LLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMiGHSKTVSYVR 668

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 418 YFDldptGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATASG-------QRVFPEPTE 490
Cdd:PLN00181 669 FVD----SSTLVSSSTDNTLKLWDLSMSISGINETPLHSFMGHTNVKNFVGLSVSDGYIATGSEtnevfvyHKAFPMPVL 744


                 .
gi 221136866 491 S 491
Cdd:PLN00181 745 S 745
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
177-481 1.28e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.13  E-value: 1.28e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 177 WAPDGSCILTNSADNILRIYNLppelyHEGEQveyaemvpvLRMVEGDTIYdycWYSLMSSaqPDTSYVASSSRENPIHI 256
Cdd:COG2319  128 FSPDGKTLASGSADGTVRLWDL-----ATGKL---------LRTLTGHSGA---VTSVAFS--PDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 257 WDAFTGELRASFRAYNHldeltAAHSLCFSPDGSQLFCG-FNRTVRVFSTARPgrdcEVRATFakkQGQSGIISCIAFSP 335
Cdd:COG2319  189 WDLATGKLLRTLTGHTG-----AVRSVAFSPDGKLLASGsADGTVRLWDLATG----KLLRTL---TGHSGSVRSVAFSP 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 336 AQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARkDAELLCWDLrQSGYPLWSLGREVTTNQ 415
Cdd:COG2319  257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD-DGTVRLWDL-ATGKLLRTLTGHTGAVR 334

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221136866 416 RIYFdlDPTGQFLVSGSTSGAVSVWDTDGpgndgkPEPVLSFLPQKDCTNGVSLHPSLPLLATASG 481
Cdd:COG2319  335 SVAF--SPDGKTLASGSDDGTVRLWDLAT------GELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-480 6.78e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 6.78e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 175 CKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVlrmvegdtiydycwyslmsSAQPDTSYVASSSRENPI 254
Cdd:cd00200   15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDV-------------------AASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 255 HIWDAFTGELRASFRAynHLDELTaahSLCFSPDGSQLF-CGFNRTVRVFSTarpgRDCEVRATFakkQGQSGIISCIAF 333
Cdd:cd00200   76 RLWDLETGECVRTLTG--HTSYVS---SVAFSPDGRILSsSSRDKTIKVWDV----ETGKCLTTL---RGHTDWVNSVAF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 334 SPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARkDAELLCWDLRQsgyplwslGREVTT 413
Cdd:cd00200  144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLST--------GKCLGT 214

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221136866 414 ----NQRIYF-DLDPTGQFLVSGSTSGAVSVWDTDgpgnDGKPEPVLSfLPQKDCTnGVSLHPSLPLLATAS 480
Cdd:cd00200  215 lrghENGVNSvAFSPDGYLLASGSEDGTIRVWDLR----TGECVQTLS-GHTNSVT-SLAWSPDGKRLASGS 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 146-441 6.92e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 6.92e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 146 WNYSFSQLPRFLSGswsefstqPENFLKGCKWAPDGSCILTNSADNILRIYNLppelyhegeqveyaEMVPVLRMVEGDT 225
Cdd:cd00200   36 WDLETGELLRTLKG--------HTGPVRDVAASADGTYLASGSSDKTIRLWDL--------------ETGECVRTLTGHT 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 226 IYdycWYSLMSSaqPDTSYVASSSRENPIHIWDAFTGELRASFRAynHLDeltAAHSLCFSPDGSQLFCG-FNRTVRVFS 304
Cdd:cd00200   94 SY---VSSVAFS--PDGRILSSSSRDKTIKVWDVETGKCLTTLRG--HTD---WVNSVAFSPDGTFVASSsQDGTIKLWD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 305 TarpgRDCEVRATFakkQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGnRFFS 384
Cdd:cd00200  164 L----RTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLA 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221136866 385 GARKDAELLCWDLRqsgyplwsLGREVTT----NQRIY-FDLDPTGQFLVSGSTSGAVSVWD 441
Cdd:cd00200  236 SGSEDGTIRVWDLR--------TGECVQTlsghTNSVTsLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
236-481 7.62e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 7.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 236 SSAQPDTSYVASSSRENPIHIWDAFTGELRASFRaynhlDELTAAHSLCFSPDGSQL-FCGFNRTVRVFSTARPgrdcev 314
Cdd:COG2319   42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLL-----GHTAAVLSVAFSPDGRLLaSASADGTVRLWDLATG------ 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 315 rATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARkDAELLC 394
Cdd:COG2319  111 -LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD-DGTVRL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 395 WDLRqSGYPLWSLGREVTTNQRIYFdlDPTGQFLVSGSTSGAVSVWDTDGpgndgkPEPVLSFLPQKDCTNGVSLHPSLP 474
Cdd:COG2319  189 WDLA-TGKLLRTLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLAT------GKLLRTLTGHSGSVRSVAFSPDGR 259


                 ....*..
gi 221136866 475 LLATASG 481
Cdd:COG2319  260 LLASGSA 266
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 322-480 1.35e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 1.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 322 QGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGArKDAELLCWDLRQsg 401
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGS-SDKTIRLWDLET-- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 402 yplwslGREVTT----NQRIY-FDLDPTGQFLVSGSTSGAVSVWDTDgpgndgKPEPVLSFLPQKDCTNGVSLHPSLPLL 476
Cdd:cd00200   83 ------GECVRTltghTSYVSsVAFSPDGRILSSSSRDKTIKVWDVE------TGKCLTTLRGHTDWVNSVAFSPDGTFV 150


                 ....
gi 221136866 477 ATAS 480
Cdd:cd00200  151 ASSS 154
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 143-304 1.50e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 1.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 143 DTAWNYSFSQLPRFLSGS--------WSEFSTQPENFLKG-------CKWAPDGSCILTNSADNILRIYNLppelyHEGE 207
Cdd:cd00200  136 DWVNSVAFSPDGTFVASSsqdgtiklWDLRTGKCVATLTGhtgevnsVAFSPDGEKLLSSSSDGTIKLWDL-----STGK 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 208 QVEyaemvpVLRmveGDTiyDYCWySLMSSaqPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHldeltAAHSLCFSP 287
Cdd:cd00200  211 CLG------TLR---GHE--NGVN-SVAFS--PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN-----SVTSLAWSP 271

                        170
                 ....*....|....*...
gi 221136866 288 DGSQLF-CGFNRTVRVFS 304
Cdd:cd00200  272 DGKRLAsGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 363-483 6.57e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 6.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 363 LGGHQGGITHLCFHPDGNRFFSGARkDAELLCWDLrQSGYPLWSLgrEVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDT 442
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSG-DGTIKVWDL-ETGELLRTL--KGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 221136866 443 DgpgndgKPEPVLSFLPQKDCTNGVSLHPSLPLLATASGQR 483
Cdd:cd00200   81 E------TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDK 115
WD40 COG2319
WD40 repeat [General function prediction only];
295-483 2.34e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 2.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 295 GFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLC 374
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 375 FHPDGNRFFSGARkDAELLCWDLrQSGYPLWSLGREVTTNQRIYFdlDPTGQFLVSGSTSGAVSVWDTDgpgnDGKPEPV 454
Cdd:COG2319   86 FSPDGRLLASASA-DGTVRLWDL-ATGLLLRTLTGHTGAVRSVAF--SPDGKTLASGSADGTVRLWDLA----TGKLLRT 157

                        170       180
                 ....*....|....*....|....*....
gi 221136866 455 LSflPQKDCTNGVSLHPSLPLLATASGQR 483
Cdd:COG2319  158 LT--GHSGAVTSVAFSPDGKLLASGSDDG 184
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 356-396 3.32e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.32e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 221136866   356 DGSPLALLGGHQGGITHLCFHPDGNRFFSGARkDAELLCWD 396
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSD-DGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
357-396 4.86e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.86e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 221136866  357 GSPLALLGGHQGGITHLCFHPDGNRFFSGARkDAELLCWD 396
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSD-DGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 180-491 2.21e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 2.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 180 DGSCILTNSADNILRIYNLPpELYHEGEQVEYaemvPVLRMVEGDTIYDYCWYSLMSSAqpdtsyVASSSRENPIHIWDA 259
Cdd:PLN00181 494 DGEFFATAGVNKKIKIFECE-SIIKDGRDIHY----PVVELASRSKLSGICWNSYIKSQ------VASSNFEGVVQVWDV 562

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 260 FTGELRASFRAYNHldeltaahslcfspdgsqlfcgfnrtvRVFStarpgrdcevratfakkqgqsgiiscIAFSPAQP- 338
Cdd:PLN00181 563 ARSQLVTEMKEHEK---------------------------RVWS--------------------------IDYSSADPt 589

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 339 LYACGSYGRSLGLYAWDDGSPLALLGGhQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSL-GREVTTNQRI 417
Cdd:PLN00181 590 LLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMiGHSKTVSYVR 668

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136866 418 YFDldptGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATASG-------QRVFPEPTE 490
Cdd:PLN00181 669 FVD----SSTLVSSSTDNTLKLWDLSMSISGINETPLHSFMGHTNVKNFVGLSVSDGYIATGSEtnevfvyHKAFPMPVL 744


                 .
gi 221136866 491 S 491
Cdd:PLN00181 745 S 745
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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