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Conserved domains on  [gi|222352168|ref|NP_001138432|]
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protein ANKUB1 isoform 1 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 13018390)

ankyrin repeat (ANK) domain-containing protein mediates specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ubl2_ANKUB1 cd17051
ubiquitin-like (Ubl) domain 2 found in Ankyrin repeat and ubiquitin domain-containing 1 ...
 80-162 2.10e-47

ubiquitin-like (Ubl) domain 2 found in Ankyrin repeat and ubiquitin domain-containing 1 (ANKUB1) and similar proteins; ANKUB1 is an uncharacterized protein with two tandem ubiquitin-like (Ubl) domains located at the N-terminal of Ankyrin repeats (ANK). The Ubl domain may have an adaptor role in ubiquitin(Ub)-signaling by mediating protein-protein interaction. Ubl proteins have a beta-grasp Ubl fold and attach to other proteins in a Ubl manner with biochemically distinct roles. The ankyrin repeats have been identified in numerous proteins with diverse functions. The family corresponds to the second Ubl domain.


:

Pssm-ID: 340571  Cd Length: 83  Bit Score: 159.74  E-value: 2.10e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352168  80 EDKPTLYVFNAVTQDTMPVMESISLLDKTVSDLRTLVTLRCGLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRLDVW 159
Cdd:cd17051    1 EIKPVLYVYCVFNQETIPIMEKINVLTTTVSQLRSIISRKTGLPVSVFRLVTPDGTEMYDCNLLDDYGIDIGTTLRLETW 80


                 ...
gi 222352168 160 DGW 162
Cdd:cd17051   81 DGW 83
Ubl1_ANKUB1 cd17050
ubiquitin-like (Ubl) domain 1 found in Ankyrin repeat and ubiquitin domain-containing 1 ...
 1-79 5.23e-42

ubiquitin-like (Ubl) domain 1 found in Ankyrin repeat and ubiquitin domain-containing 1 (ANKUB1) and similar proteins; ANKUB1 is an uncharacterized protein with two tandem ubiquitin-like (Ubl) domains located at the N-terminal of Ankyrin repeats (ANK). The Ubl domain may have an adaptor role in ubiquitin (Ub)-signaling by mediating protein-protein interaction. Ubl proteins have a beta-grasp Ubl fold and attach to other proteins in a Ubl manner with biochemically distinct roles. The ankyrin repeats have been identified in numerous proteins with diverse functions. The family corresponds to the first Ubl domain.


:

Pssm-ID: 340570  Cd Length: 79  Bit Score: 145.13  E-value: 5.23e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 222352168   1 MRIFIAFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKQGRRYLELMYAGAALKDSWSLADVGISFCSTLKCFVKE 79
Cdd:cd17050    1 MRIFVAFEGEREPLDVSPGQTVGDVKEMIRDKFHIDLSDGKQGRKFLVLTYAGADLQDSWVLSDIGIPPGSTIRCLLRE 79
Ank_2 pfam12796
Ankyrin repeats (3 copies);
196-296 1.19e-07

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.73  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352168  196 LYIAAFCGYIELTEWALKQGARPHeavgvhpyrawcheaLHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKnaaGQ 275
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN---------------LQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN---GR 62

                          90       100
                  ....*....|....*....|.
gi 222352168  276 TPLTIVFKHKHKDCVLYLLSK 296
Cdd:pfam12796  63 TALHYAARSGHLEIVKLLLEK 83
 
Name Accession Description Interval E-value
Ubl2_ANKUB1 cd17051
ubiquitin-like (Ubl) domain 2 found in Ankyrin repeat and ubiquitin domain-containing 1 ...
 80-162 2.10e-47

ubiquitin-like (Ubl) domain 2 found in Ankyrin repeat and ubiquitin domain-containing 1 (ANKUB1) and similar proteins; ANKUB1 is an uncharacterized protein with two tandem ubiquitin-like (Ubl) domains located at the N-terminal of Ankyrin repeats (ANK). The Ubl domain may have an adaptor role in ubiquitin(Ub)-signaling by mediating protein-protein interaction. Ubl proteins have a beta-grasp Ubl fold and attach to other proteins in a Ubl manner with biochemically distinct roles. The ankyrin repeats have been identified in numerous proteins with diverse functions. The family corresponds to the second Ubl domain.


Pssm-ID: 340571  Cd Length: 83  Bit Score: 159.74  E-value: 2.10e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352168  80 EDKPTLYVFNAVTQDTMPVMESISLLDKTVSDLRTLVTLRCGLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRLDVW 159
Cdd:cd17051    1 EIKPVLYVYCVFNQETIPIMEKINVLTTTVSQLRSIISRKTGLPVSVFRLVTPDGTEMYDCNLLDDYGIDIGTTLRLETW 80


                 ...
gi 222352168 160 DGW 162
Cdd:cd17051   81 DGW 83
Ubl1_ANKUB1 cd17050
ubiquitin-like (Ubl) domain 1 found in Ankyrin repeat and ubiquitin domain-containing 1 ...
 1-79 5.23e-42

ubiquitin-like (Ubl) domain 1 found in Ankyrin repeat and ubiquitin domain-containing 1 (ANKUB1) and similar proteins; ANKUB1 is an uncharacterized protein with two tandem ubiquitin-like (Ubl) domains located at the N-terminal of Ankyrin repeats (ANK). The Ubl domain may have an adaptor role in ubiquitin (Ub)-signaling by mediating protein-protein interaction. Ubl proteins have a beta-grasp Ubl fold and attach to other proteins in a Ubl manner with biochemically distinct roles. The ankyrin repeats have been identified in numerous proteins with diverse functions. The family corresponds to the first Ubl domain.


Pssm-ID: 340570  Cd Length: 79  Bit Score: 145.13  E-value: 5.23e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 222352168   1 MRIFIAFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKQGRRYLELMYAGAALKDSWSLADVGISFCSTLKCFVKE 79
Cdd:cd17050    1 MRIFVAFEGEREPLDVSPGQTVGDVKEMIRDKFHIDLSDGKQGRKFLVLTYAGADLQDSWVLSDIGIPPGSTIRCLLRE 79
Ank_2 pfam12796
Ankyrin repeats (3 copies);
196-296 1.19e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.73  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352168  196 LYIAAFCGYIELTEWALKQGARPHeavgvhpyrawcheaLHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKnaaGQ 275
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN---------------LQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN---GR 62

                          90       100
                  ....*....|....*....|.
gi 222352168  276 TPLTIVFKHKHKDCVLYLLSK 296
Cdd:pfam12796  63 TALHYAARSGHLEIVKLLLEK 83
ubiquitin pfam00240
Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homolog) ...
 3-78 5.57e-05

Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homolog), Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.


Pssm-ID: 459726 [Multi-domain]  Cd Length: 72  Bit Score: 41.39  E-value: 5.57e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 222352168    3 IFIAFEGSFE-PFDVSADETVEVVKLMIKDYFHIPLSEDKqgrryleLMYAGAALKDSWSLADVGISFCSTLKCFVK 78
Cdd:pfam00240   1 ITVKTLDGKKiTLEVDPTDTVLELKEKIAEKEGVPPEQQR-------LIYSGKVLEDDQTLGEYGIEDGSTIHLVLR 70
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
195-296 1.42e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.79  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352168 195 ALYIAAFCGYIELTEWALKQGARPHEAvgvhpyrawchealhADVSKCPIHAAAEAGQLLILKAFVNYSVLcLECKNAAG 274
Cdd:COG0666  156 PLHLAAANGNLEIVKLLLEAGADVNAR---------------DNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDG 219

                         90       100
                 ....*....|....*....|..
gi 222352168 275 QTPLTIVFKHKHKDCVLYLLSK 296
Cdd:COG0666  220 KTALDLAAENGNLEIVKLLLEA 241
UBQ smart00213
Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of ...
 1-78 3.38e-04

Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression


Pssm-ID: 214563 [Multi-domain]  Cd Length: 72  Bit Score: 39.16  E-value: 3.38e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 222352168     1 MRIFI-AFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKqgrryleLMYAGAALKDSWSLADVGISFCSTLKCFVK 78
Cdd:smart00213   1 IELTVkTLDGKTITLEVKPSDTVSELKEKIAELTGIPPEQQR-------LIYKGKVLEDDRTLADYGIQDGSTIHLVLR 72
 
Name Accession Description Interval E-value
Ubl2_ANKUB1 cd17051
ubiquitin-like (Ubl) domain 2 found in Ankyrin repeat and ubiquitin domain-containing 1 ...
 80-162 2.10e-47

ubiquitin-like (Ubl) domain 2 found in Ankyrin repeat and ubiquitin domain-containing 1 (ANKUB1) and similar proteins; ANKUB1 is an uncharacterized protein with two tandem ubiquitin-like (Ubl) domains located at the N-terminal of Ankyrin repeats (ANK). The Ubl domain may have an adaptor role in ubiquitin(Ub)-signaling by mediating protein-protein interaction. Ubl proteins have a beta-grasp Ubl fold and attach to other proteins in a Ubl manner with biochemically distinct roles. The ankyrin repeats have been identified in numerous proteins with diverse functions. The family corresponds to the second Ubl domain.


Pssm-ID: 340571  Cd Length: 83  Bit Score: 159.74  E-value: 2.10e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352168  80 EDKPTLYVFNAVTQDTMPVMESISLLDKTVSDLRTLVTLRCGLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRLDVW 159
Cdd:cd17051    1 EIKPVLYVYCVFNQETIPIMEKINVLTTTVSQLRSIISRKTGLPVSVFRLVTPDGTEMYDCNLLDDYGIDIGTTLRLETW 80


                 ...
gi 222352168 160 DGW 162
Cdd:cd17051   81 DGW 83
Ubl1_ANKUB1 cd17050
ubiquitin-like (Ubl) domain 1 found in Ankyrin repeat and ubiquitin domain-containing 1 ...
 1-79 5.23e-42

ubiquitin-like (Ubl) domain 1 found in Ankyrin repeat and ubiquitin domain-containing 1 (ANKUB1) and similar proteins; ANKUB1 is an uncharacterized protein with two tandem ubiquitin-like (Ubl) domains located at the N-terminal of Ankyrin repeats (ANK). The Ubl domain may have an adaptor role in ubiquitin (Ub)-signaling by mediating protein-protein interaction. Ubl proteins have a beta-grasp Ubl fold and attach to other proteins in a Ubl manner with biochemically distinct roles. The ankyrin repeats have been identified in numerous proteins with diverse functions. The family corresponds to the first Ubl domain.


Pssm-ID: 340570  Cd Length: 79  Bit Score: 145.13  E-value: 5.23e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 222352168   1 MRIFIAFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKQGRRYLELMYAGAALKDSWSLADVGISFCSTLKCFVKE 79
Cdd:cd17050    1 MRIFVAFEGEREPLDVSPGQTVGDVKEMIRDKFHIDLSDGKQGRKFLVLTYAGADLQDSWVLSDIGIPPGSTIRCLLRE 79
Ubl_ubiquitin_like cd17039
ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like ...
 9-76 6.36e-08

ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like (Ubl) proteins have a similar ubiquitin (Ub) beta-grasp fold and attach to other proteins in a Ubl manner but with biochemically distinct roles. Ub and Ubl proteins conjugate and deconjugate via ligases and peptidases to covalently modify target polypeptides. Some Ubl domains have adaptor roles in Ub-signaling by mediating protein-protein interaction. Prokaryotic sulfur carrier proteins are Ub-related proteins that can be activated in an ATP-dependent manner. Polyubiquitination signals for a diverse set of cellular events via different isopeptide linkages formed between the C terminus of one ubiquitin (Ub) and the epsilon-amine of K6, K11, K27, K29, K33, K48, or K63 of a second Ub. One of these seven lysine residues (K27, Ub numbering) is conserved in this Ubl_ubiquitin_like family. K27-linked Ub chains are versatile and can be recognized by several downstream receptor proteins. K27 has roles beyond chain linkage, such as in Ubl NEDD8 (which contains many of the same lysines (K6, K11, K27, K33, K48) as Ub) where K27 has a role (other than conjugation) in the mechanism of protein neddylation.


Pssm-ID: 340559 [Multi-domain]  Cd Length: 68  Bit Score: 49.52  E-value: 6.36e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 222352168   9 GSFEPFDVSADETVEVVKLMIKDYFHIPLSEdkqgrryLELMYAGAALKDSWSLADVGISFCSTLKCF 76
Cdd:cd17039    8 GKTYTVEVDPDDTVADLKEKIEEKTGIPVEQ-------QRLIYNGKELKDDKTLSDYGIKDGSTIHLV 68
Ank_2 pfam12796
Ankyrin repeats (3 copies);
196-296 1.19e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.73  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352168  196 LYIAAFCGYIELTEWALKQGARPHeavgvhpyrawcheaLHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKnaaGQ 275
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAN---------------LQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN---GR 62

                          90       100
                  ....*....|....*....|.
gi 222352168  276 TPLTIVFKHKHKDCVLYLLSK 296
Cdd:pfam12796  63 TALHYAARSGHLEIVKLLLEK 83
ubiquitin pfam00240
Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homolog) ...
 3-78 5.57e-05

Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homolog), Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.


Pssm-ID: 459726 [Multi-domain]  Cd Length: 72  Bit Score: 41.39  E-value: 5.57e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 222352168    3 IFIAFEGSFE-PFDVSADETVEVVKLMIKDYFHIPLSEDKqgrryleLMYAGAALKDSWSLADVGISFCSTLKCFVK 78
Cdd:pfam00240   1 ITVKTLDGKKiTLEVDPTDTVLELKEKIAEKEGVPPEQQR-------LIYSGKVLEDDQTLGEYGIEDGSTIHLVLR 70
Ank_4 pfam13637
Ankyrin repeats (many copies);
243-294 1.10e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 1.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 222352168  243 PIHAAAEAGQLLILKAFVNYSVlCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
195-296 1.42e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.79  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352168 195 ALYIAAFCGYIELTEWALKQGARPHEAvgvhpyrawchealhADVSKCPIHAAAEAGQLLILKAFVNYSVLcLECKNAAG 274
Cdd:COG0666  156 PLHLAAANGNLEIVKLLLEAGADVNAR---------------DNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDG 219

                         90       100
                 ....*....|....*....|..
gi 222352168 275 QTPLTIVFKHKHKDCVLYLLSK 296
Cdd:COG0666  220 KTALDLAAENGNLEIVKLLLEA 241
UBQ smart00213
Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of ...
 1-78 3.38e-04

Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression


Pssm-ID: 214563 [Multi-domain]  Cd Length: 72  Bit Score: 39.16  E-value: 3.38e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 222352168     1 MRIFI-AFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKqgrryleLMYAGAALKDSWSLADVGISFCSTLKCFVK 78
Cdd:smart00213   1 IELTVkTLDGKTITLEVKPSDTVSELKEKIAELTGIPPEQQR-------LIYKGKVLEDDRTLADYGIQDGSTIHLVLR 72
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
195-296 6.09e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.86  E-value: 6.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352168 195 ALYIAAFCGYIELTEWALKQGARPHeavgvhpYRAWCHEAlhadvskcPIHAAAEAGQLLILKAFVNYSVLcLECKNAAG 274
Cdd:COG0666   90 LLHAAARNGDLEIVKLLLEAGADVN-------ARDKDGET--------PLHLAAYNGNLEIVKLLLEAGAD-VNAQDNDG 153

                         90       100
                 ....*....|....*....|..
gi 222352168 275 QTPLTIVFKHKHKDCVLYLLSK 296
Cdd:COG0666  154 NTPLHLAAANGNLEIVKLLLEA 175
Ank_2 pfam12796
Ankyrin repeats (3 copies);
244-297 6.80e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.94  E-value: 6.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 222352168  244 IHAAAEAGQLLILKAFVNYSVLClECKNAAGQTPLTIVFKHKHKDCVLYLLSKM 297
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLEHA 53
Ubl_ubiquitin cd01803
ubiquitin-like (Ubl) domain found in ubiquitin; Ubiquitin is a protein modifier in eukaryotes ...
 1-73 1.13e-03

ubiquitin-like (Ubl) domain found in ubiquitin; Ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Ubiquitination is comprised of a cascade of E1, E2 and E3 enzymes that results in a covalent bond between the C-terminus of ubiquitin and the epsilon-amino group of a substrate lysine. Ubiquitin-like (Ubl) proteins have similar ubiquitin beta-grasp fold and attach to other proteins in a Ubl manner but with biochemically distinct roles. Ubiquitin (Ub)and Ubl proteins conjugate and deconjugate via ligases and peptidases to covalently modify target polypeptides. Ub includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric multiubiquitin protein chains.


Pssm-ID: 340501 [Multi-domain]  Cd Length: 76  Bit Score: 37.81  E-value: 1.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 222352168   1 MRIFI-AFEGSFEPFDVSADETVEVVKLMIKDYFHIPLseDKQgrrylELMYAGAALKDSWSLADVGISFCSTL 73
Cdd:cd01803    1 MQIFVkTLTGKTITLEVEPSDTIENVKAKIQDKEGIPP--DQQ-----RLIFAGKQLEDGRTLSDYNIQKESTL 67
Ubl_ubiquitin_like cd17039
ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like ...
 106-156 2.11e-03

ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like (Ubl) proteins have a similar ubiquitin (Ub) beta-grasp fold and attach to other proteins in a Ubl manner but with biochemically distinct roles. Ub and Ubl proteins conjugate and deconjugate via ligases and peptidases to covalently modify target polypeptides. Some Ubl domains have adaptor roles in Ub-signaling by mediating protein-protein interaction. Prokaryotic sulfur carrier proteins are Ub-related proteins that can be activated in an ATP-dependent manner. Polyubiquitination signals for a diverse set of cellular events via different isopeptide linkages formed between the C terminus of one ubiquitin (Ub) and the epsilon-amine of K6, K11, K27, K29, K33, K48, or K63 of a second Ub. One of these seven lysine residues (K27, Ub numbering) is conserved in this Ubl_ubiquitin_like family. K27-linked Ub chains are versatile and can be recognized by several downstream receptor proteins. K27 has roles beyond chain linkage, such as in Ubl NEDD8 (which contains many of the same lysines (K6, K11, K27, K33, K48) as Ub) where K27 has a role (other than conjugation) in the mechanism of protein neddylation.


Pssm-ID: 340559 [Multi-domain]  Cd Length: 68  Bit Score: 36.81  E-value: 2.11e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 222352168 106 DKTVSDLRTLVTLRCGLPVSVYCLRTpRGLEMYDCNTLKDYQTDIGTTLRL 156
Cdd:cd17039   18 DDTVADLKEKIEEKTGIPVEQQRLIY-NGKELKDDKTLSDYGIKDGSTIHL 67
Ubl_USP48 cd01795
ubiquitin-like (Ubl) domain found in ubiquitin-specific-processing protease 48 (USP48) and ...
 16-97 2.96e-03

ubiquitin-like (Ubl) domain found in ubiquitin-specific-processing protease 48 (USP48) and similar proteins; USP48, also termed USP31, or deubiquitinating enzyme 48, or ubiquitin thioesterase 48, or ubiquitin carboxyl-terminal hydrolase 48, belongs to the ubiquitin specific protease (USP) family that is one of at least seven deubiquitylating enzyme (DUB) families capable of deconjugating ubiquitin (Ub)and ubiquitin-like (Ubl) adducts. While the USP proteins have a conserved catalytic core domain, USP48 differs in its domain architecture. It contains an N-terminal USP domain, three DUSP (domain present in ubiquitin-specific protease) domains, and a C-terminal Ubl domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions. USP48 is a deubiquitinating enzyme that interacts with TNF receptor-associated factor 2 (TRAF2) and has been implicated in activation of nuclear factor-kappaB (NF-kappaB). Moreover, as a nuclear deubiquitinase regulated by casein kinase 2 (CK2), USP48 controls the ubiquitin/proteasome-system (UPS)-dependent turnover of activated NF-kappaB/RelA in the nucleus together with the COP9 signalosome, suggesting a role of USP48 in a timely control of immune responses.


Pssm-ID: 340493 [Multi-domain]  Cd Length: 99  Bit Score: 37.26  E-value: 2.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352168  16 VSADETVEVVKLMIKDYFHIPLSedkqgrrYLELMYAGAALKD-SWSLADVGISFCSTLKCFVKEE-DKPTLYVFNAVTQ 93
Cdd:cd01795   12 VSSTTTLKELKLQIMEKFSVAPF-------DQHLYFNGRELTDdSATLADLGILPGDVLYLKVDEPpDDPDDADEADVSR 84


                 ....
gi 222352168  94 DTMP 97
Cdd:cd01795   85 ARVP 88
Ubl_FUBI cd01793
ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins; FUBI is ...
 1-78 4.91e-03

ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins; FUBI is a pro-apoptotic regulatory gene FAU encoding ubiquitin-like protein with ribosomal protein S30 as a C-terminal extension. FUBI functions as a tumor suppressor protein that may be involved in the ATP-dependent proteolytic activity of ubiquitin. The N-terminal ubiquitin-like (Ubl) domain of FUBI has the beta-grasp Ubl fold, and it may act as a substitute or an inhibitor of ubiquitin or one of ubiquitin's close relatives UCRP, FAT10, and Nedd8.


Pssm-ID: 340491  Cd Length: 74  Bit Score: 36.11  E-value: 4.91e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 222352168   1 MRIFIAfEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEdkqgrryLELMYAGAALKDSWSLADVGISFCSTLKCFVK 78
Cdd:cd01793    1 MQLFVR-AQSLHTLEVSGNETVADIKAHIAALEGIAVED-------QVLLYAGAPLEDDVVLGQCGIPDLATLEVAVR 70
Ubl_ANKRD60 cd17063
ubiquitin-like (Ubl) domain found in ankyrin repeat domain-containing protein 60 (ANKRD60) and ...
 84-159 7.03e-03

ubiquitin-like (Ubl) domain found in ankyrin repeat domain-containing protein 60 (ANKRD60) and similar proteins; ANKRD60 is an uncharacterized ankyrin repeat domain-containing protein which also harbors a conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions.


Pssm-ID: 340583  Cd Length: 77  Bit Score: 35.72  E-value: 7.03e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222352168  84 TLYVFNAVTQDTMPVMESISLLdkTVSDLRTLVTLRCGLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRLDVW 159
Cdd:cd17063    4 SLKLRLPETEETFTVPNCYPGM--KVKELKSRLELVTGIPSHLQRLSYLDEGDLMDDSTLKYNDIVPGATITLRVW 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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