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Conserved domains on  [gi|281427282|ref|NP_001139206|]
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cell division cycle protein 20 homolog B isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
247-475 4.68e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.31  E-value: 4.68e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 247 IALGSA---VYIWNGENHNGIENIDLSLtcNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW 323
Cdd:COG2319  177 LASGSDdgtVRLWDLATGKLLRTLTGHT--GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 324 NH--FILSSGSRLGRVYHHDVRvAQHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgasAQGQPLKVITQ 400
Cdd:COG2319  255 SPdgRLLASGSADGTVRLWDLA-TGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLW--DL---ATGKLLRTLTG 328

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281427282 401 STAvKICSLIWLPKTKEIATG--QGTpkndVTVWTCPTVSRSGGFFGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 475
Cdd:COG2319  329 HTG-AVRSVAFSPDGKTLASGsdDGT----VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
247-475 4.68e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.31  E-value: 4.68e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 247 IALGSA---VYIWNGENHNGIENIDLSLtcNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW 323
Cdd:COG2319  177 LASGSDdgtVRLWDLATGKLLRTLTGHT--GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 324 NH--FILSSGSRLGRVYHHDVRvAQHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgasAQGQPLKVITQ 400
Cdd:COG2319  255 SPdgRLLASGSADGTVRLWDLA-TGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLW--DL---ATGKLLRTLTG 328

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281427282 401 STAvKICSLIWLPKTKEIATG--QGTpkndVTVWTCPTVSRSGGFFGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 475
Cdd:COG2319  329 HTG-AVRSVAFSPDGKTLASGsdDGT----VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 236-475 6.79e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 6.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 236 ILDWSFQNLVAIA-LGSAVYIWNGENhnGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGH 314
Cdd:cd00200   57 VAASADGTYLASGsSDKTIRLWDLET--GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 315 LSVVGALSWNHF--ILSSGSRLG--RVYhhDVRvAQHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgas 389
Cdd:cd00200  135 TDWVNSVAFSPDgtFVASSSQDGtiKLW--DLR-TGKCVATLTgHTGEVNSVAFSPDGEKLLSSSSDGTIKLW--DL--- 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 390 AQGQPLKVITQSTAvKICSLIWLPKTKEIATgqGTPKNDVTVWTCPTVSRSGGFFGHRGRVLHLSLSPDQTRVFSAAADG 469
Cdd:cd00200  207 STGKCLGTLRGHEN-GVNSVAFSPDGYLLAS--GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADG 283


                 ....*.
gi 281427282 470 TASVWN 475
Cdd:cd00200  284 TIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-382 3.43e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.43e-05
                           10        20
                   ....*....|....*....|....*....
gi 281427282   354 HKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
354-382 1.87e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.87e-04
                          10        20
                  ....*....|....*....|....*....
gi 281427282  354 HKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
247-475 4.68e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.31  E-value: 4.68e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 247 IALGSA---VYIWNGENHNGIENIDLSLtcNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW 323
Cdd:COG2319  177 LASGSDdgtVRLWDLATGKLLRTLTGHT--GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 324 NH--FILSSGSRLGRVYHHDVRvAQHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgasAQGQPLKVITQ 400
Cdd:COG2319  255 SPdgRLLASGSADGTVRLWDLA-TGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLW--DL---ATGKLLRTLTG 328

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281427282 401 STAvKICSLIWLPKTKEIATG--QGTpkndVTVWTCPTVSRSGGFFGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 475
Cdd:COG2319  329 HTG-AVRSVAFSPDGKTLASGsdDGT----VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
274-475 7.13e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 7.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 274 NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW--NHFILSSGSRLGRVYHHDVRvAQHHVGT 351
Cdd:COG2319  163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLA-TGKLLRT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 352 LR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgasAQGQPLKVITQSTAvKICSLIWLPKTKEIATG--QGTpknd 428
Cdd:COG2319  242 LTgHSGSVRSVAFSPDGRLLASGSADGTVRLW--DL---ATGELLRTLTGHSG-GVNSVAFSPDGKLLASGsdDGT---- 311

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 281427282 429 VTVWTCPTVSRSGGFFGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 475
Cdd:COG2319  312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
244-475 2.01e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 244 LVAIALGSAVYIWNGENhnGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW 323
Cdd:COG2319   93 LASASADGTVRLWDLAT--GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 324 NH--FILSSGSRLGRVYHHDVRVAQhHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgasAQGQPLKVITQ 400
Cdd:COG2319  171 SPdgKLLASGSDDGTVRLWDLATGK-LLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLW--DL---ATGKLLRTLTG 244

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281427282 401 STAVkICSLIWLPKTKEIATgqGTPKNDVTVWTCPTVSRSGGFFGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 475
Cdd:COG2319  245 HSGS-VRSVAFSPDGRLLAS--GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
237-475 1.37e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.30  E-value: 1.37e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 237 LDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLS 316
Cdd:COG2319   42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 317 VVGALSW--NHFILSSGSRLGRVYHHDVRVAQhHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWphdpgASAQGQ 393
Cdd:COG2319  122 AVRSVAFspDGKTLASGSADGTVRLWDLATGK-LLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRLW-----DLATGK 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 394 PLKVITQSTAVkICSLIWLPKTKEIATG--QGTpkndVTVWTCPTVSRSGGFFGHRGRVLHLSLSPDQTRVFSAAADGTA 471
Cdd:COG2319  196 LLRTLTGHTGA-VRSVAFSPDGKLLASGsaDGT----VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270


                 ....
gi 281427282 472 SVWN 475
Cdd:COG2319  271 RLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 236-475 6.79e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 6.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 236 ILDWSFQNLVAIA-LGSAVYIWNGENhnGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGH 314
Cdd:cd00200   57 VAASADGTYLASGsSDKTIRLWDLET--GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 315 LSVVGALSWNHF--ILSSGSRLG--RVYhhDVRvAQHHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgas 389
Cdd:cd00200  135 TDWVNSVAFSPDgtFVASSSQDGtiKLW--DLR-TGKCVATLTgHTGEVNSVAFSPDGEKLLSSSSDGTIKLW--DL--- 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 390 AQGQPLKVITQSTAvKICSLIWLPKTKEIATgqGTPKNDVTVWTCPTVSRSGGFFGHRGRVLHLSLSPDQTRVFSAAADG 469
Cdd:cd00200  207 STGKCLGTLRGHEN-GVNSVAFSPDGYLLAS--GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADG 283


                 ....*.
gi 281427282 470 TASVWN 475
Cdd:cd00200  284 TIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
276-475 8.44e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 8.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVG--ALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLR 353
Cdd:COG2319   39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLsvAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgasAQGQPLKVITQSTAvKICSLIWLPKTKEIATG--QGTpkndVTV 431
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLW--DL---ATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGsdDGT----VRL 188

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 281427282 432 WTCPTVSRSGGFFGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 475
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 276-475 1.10e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 1.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW--NHFILSSGSRLGRVYHHDVRVAQHhVGTLR 353
Cdd:cd00200   54 VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGKC-LTTLR 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 354 -HKQAVCALKWSPDGRLLSSGCSDGLLTIWphdpgasaqgqplkvitqstavkicsliwlpktkEIATGQgtpkndvTVW 432
Cdd:cd00200  133 gHTDWVNSVAFSPDGTFVASSSQDGTIKLW----------------------------------DLRTGK-------CVA 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 281427282 433 TcptvsrsggFFGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 475
Cdd:cd00200  172 T---------LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 274-475 2.97e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 2.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 274 NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW---NHFILSSGS-RLGRVYhhDVRvAQHHV 349
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsadGTYLASGSSdKTIRLW--DLE-TGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 350 GTLR-HKQAVCALKWSPDGRLLSSGCSDGllTIWphdpgasaqgqplkvitqstavkicslIW-LPKTKEIATgqgtpkn 427
Cdd:cd00200   87 RTLTgHTSYVSSVAFSPDGRILSSSSRDK--TIK---------------------------VWdVETGKCLTT------- 130

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 281427282 428 dvtvwtcptvsrsggFFGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 475
Cdd:cd00200  131 ---------------LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163
WD40 COG2319
WD40 repeat [General function prediction only];
288-475 1.65e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 1.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHF--ILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSP 365
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDgaRLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 366 DGRLLSSGCSDGLLTIWphdpgaSAQGQPLKVITQSTAVKICSLIWLPKTKEIATGqGTPKNdVTVWTCPTVSRSGGFFG 445
Cdd:COG2319   89 DGRLLASASADGTVRLW------DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASG-SADGT-VRLWDLATGKLLRTLTG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 281427282 446 HRGRVLHLSLSPDQTRVFSAAADGTASVWN 475
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 COG2319
WD40 repeat [General function prediction only];
320-475 3.72e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 3.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427282 320 ALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPhdpgasAQGQPLKVIT 399
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLD------AAAGALLATL 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281427282 400 QSTAVKICSLIWLPKTKEIATGQGTpkNDVTVWTCPTVSRSGGFFGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 475
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASAD--GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-382 3.43e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.43e-05
                           10        20
                   ....*....|....*....|....*....
gi 281427282   354 HKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
354-382 1.87e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.87e-04
                          10        20
                  ....*....|....*....|....*....
gi 281427282  354 HKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 443-475 3.23e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.23e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281427282   443 FFGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 475
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
443-475 7.05e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 7.05e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 281427282  443 FFGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 475
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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