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Conserved domains on  [gi|226342982|ref|NP_001139740|]
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platelet-derived growth factor receptor beta isoform 1 precursor [Mus musculus]

Protein Classification

platelet-derived growth factor receptor beta( domain architecture ID 10441190)

platelet-derived growth factor receptor beta is a receptor tyrosine kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates; binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PKc_like super family cl21453
Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the ...
562-953 0e+00

Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.


The actual alignment was detected with superfamily member cd05107:

Pssm-ID: 473864 [Multi-domain]  Cd Length: 401  Bit Score: 851.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  562 YEIRWKVIESVSSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTAR 641
Cdd:cd05107     1 YEIRWKVIESVSSDGHEYIYVDPMQLPYDSAWEMPRDNLVLGRTLGSGAFGRVVEATAHGLSHSQSTMKVAVKMLKSTAR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  642 SSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSaELYSNALP 721
Cdd:cd05107    81 SSEKQALMSELKIMSHLGPHLNIVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQYYLDKNRDDG-SLISGGST 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  722 VGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRATLINDSPVLSYT 801
Cdd:cd05107   160 PLSQRKSHVSLGSESDGGYMDMSKDESADYVPMQDMKGTVKYADIESSNYESPYDQYLPSAPERTRRDTLINESPALSYM 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  802 DLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYT 881
Cdd:cd05107   240 DLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNNLYT 319
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  882 TLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05107   320 TLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAKPAHASDEIYEIMQKCWEEKFEIRPDFSQ 391
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
313-414 7.38e-42

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05859:

Pssm-ID: 472250  Cd Length: 101  Bit Score: 148.47  E-value: 7.38e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  313 GYVRLLETLGDVEIAELHRSRTLRVVFEAYPMPSVLWLKDNRTLGDSgAGELVLSTRNMSETRYVSELILVRVKVSEAGY 392
Cdd:cd05859     1 GFIALKPTFGQLEFANLHEVKEFVVEVEAYPPPQIRWLKDNRTLIEN-LTEITTSTRNVQETRYVSKLKLIRAKEEDSGL 79
                          90       100
                  ....*....|....*....|..
gi 226342982  393 YTMRAFHEDDEVQLSFKLQVNV 414
Cdd:cd05859    80 YTALAQNEDAVKSYTFALQIQV 101
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
211-309 1.11e-40

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05861:

Pssm-ID: 472250  Cd Length: 99  Bit Score: 145.05  E-value: 1.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  211 SSINVSVNAVQTVVRQGESITIRCIVMGNDVVNFQWTYPRMKSGRLVEPVTDYLfgVPS-RIGSILHIPTAELSDSGTYT 289
Cdd:cd05861     1 SSINVEMEAVKTVVRQGETITLMCIVIGNEVVDLEWTYPGKESGRGIEPVEEFK--VPPyHLVYTLTIPSATLEDSGTYE 78
                          90       100
                  ....*....|....*....|
gi 226342982  290 CNVSVSVNDHGDEKAINISV 309
Cdd:cd05861    79 CAVTEATNDHQDEKKINITV 98
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
36-113 1.29e-10

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


:

Pssm-ID: 395002  Cd Length: 86  Bit Score: 58.75  E-value: 1.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    36 PPGPEFVLNISSTFVLTCSGS-----APVMWEQMSQVP--WQEAAMNQDGTFSSVLTLTNVTGGDTGEYFCVYNNSLGPE 108
Cdd:pfam00047    1 SAPPTVTVLEGDSATLTCSAStgspgPDVTWSKEGGTLieSLKVKHDNGRTTQSSLLISNVTKEDAGTYTCVVNNPGGSA 80

                   ....*
gi 226342982   109 LSERK 113
Cdd:pfam00047   81 TLSTS 85
 
Name Accession Description Interval E-value
PTKc_PDGFR_beta cd05107
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; ...
562-953 0e+00

Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. PDGFR beta is a receptor PTK (RTK) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR beta forms homodimers or heterodimers with PDGFR alpha, depending on the nature of the PDGF ligand. PDGF-BB and PDGF-DD induce PDGFR beta homodimerization. PDGFR signaling plays many roles in normal embryonic development and adult physiology. PDGFR beta signaling leads to a variety of cellular effects including the stimulation of cell growth and chemotaxis, as well as the inhibition of apoptosis and GAP junctional communication. It is critical in normal angiogenesis as it is involved in the recruitment of pericytes and smooth muscle cells essential for vessel stability. Aberrant PDGFR beta expression is associated with some human cancers. The continuously-active fusion proteins of PDGFR beta with COL1A1 and TEL are associated with dermatofibrosarcoma protuberans (DFSP) and a subset of chronic myelomonocytic leukemia (CMML), respectively. The PDGFR beta subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133238 [Multi-domain]  Cd Length: 401  Bit Score: 851.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  562 YEIRWKVIESVSSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTAR 641
Cdd:cd05107     1 YEIRWKVIESVSSDGHEYIYVDPMQLPYDSAWEMPRDNLVLGRTLGSGAFGRVVEATAHGLSHSQSTMKVAVKMLKSTAR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  642 SSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSaELYSNALP 721
Cdd:cd05107    81 SSEKQALMSELKIMSHLGPHLNIVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQYYLDKNRDDG-SLISGGST 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  722 VGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRATLINDSPVLSYT 801
Cdd:cd05107   160 PLSQRKSHVSLGSESDGGYMDMSKDESADYVPMQDMKGTVKYADIESSNYESPYDQYLPSAPERTRRDTLINESPALSYM 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  802 DLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYT 881
Cdd:cd05107   240 DLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNNLYT 319
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  882 TLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05107   320 TLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAKPAHASDEIYEIMQKCWEEKFEIRPDFSQ 391
PK_Tyr_Ser-Thr pfam07714
Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role ...
600-953 1.45e-118

Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyze the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyze the reverse process. Protein kinases fall into three broad classes, characterized with respect to substrate specificity; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.


Pssm-ID: 462242 [Multi-domain]  Cd Length: 258  Bit Score: 365.67  E-value: 1.45e-118
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   600 LVLGRTLGSGAFGQVVEATAHGlSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACTKGGPIYI 679
Cdd:pfam07714    1 LTLGEKLGEGAFGEVYKGTLKG-EGENTKIKVAVKTLKEGADEEEREDFLEEASIMKKL-DHPNIVKLLGVCTQGEPLYI 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   680 ITEYCRYGDLVDYLHRNKHTflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkg 759
Cdd:pfam07714   79 VTEYMPGGDLLDFLRKHKRK------------------------------------------------------------ 98
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   760 dikyadiespsymapydnyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKL 839
Cdd:pfam07714   99 --------------------------------------LTLKDLLSMALQIAKGMEYLESKNFVHRDLAARNCLVSENLV 140
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   840 VKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKR 919
Cdd:pfam07714  141 VKISDFGLSRDIYDDDYYRKRGGGKLPIKWMAPESLKDGKFTSKSDVWSFGVLLWEIFTLGEQPYPGMS-NEEVLEFLED 219
                          330       340       350
                   ....*....|....*....|....*....|....
gi 226342982   920 GYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:pfam07714  220 GYRLPQPENCPDELYDLMKQCWAYDPEDRPTFSE 253
STYKc smart00221
Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class ...
600-953 2.24e-106

Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase.


Pssm-ID: 214568 [Multi-domain]  Cd Length: 258  Bit Score: 333.36  E-value: 2.24e-106
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    600 LVLGRTLGSGAFGQVVEATAHGLSHSQaTMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYI 679
Cdd:smart00221    1 LTLGKKLGEGAFGEVYKGTLKGKGDGK-EVEVAVKTLKEDASEQQIEEFLREARIMRKLD-HPNIVKLLGVCTEEEPLMI 78
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    680 ITEYCRYGDLVDYLHRNKHTFLqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkg 759
Cdd:smart00221   79 VMEYMPGGDLLDYLRKNRPKEL---------------------------------------------------------- 100
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    760 dikyadiespsymapydnyvpsapertyratlindspvlSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKL 839
Cdd:smart00221  101 ---------------------------------------SLSDLLSFALQIARGMEYLESKNFIHRDLAARNCLVGENLV 141
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    840 VKICDFGLARDIMRDSNYISKGSTfLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKR 919
Cdd:smart00221  142 VKISDFGLSRDLYDDDYYKVKGGK-LPIRWMAPESLKEGKFTSKSDVWSFGVLLWEIFTLGEEPYPGMS-NAEVLEYLKK 219
                           330       340       350
                    ....*....|....*....|....*....|....
gi 226342982    920 GYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:smart00221  220 GYRLPKPPNCPPELYKLMLQCWAEDPEDRPTFSE 253
Ig4_PDGFR cd05859
Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR); The ...
313-414 7.38e-42

Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR); The members here are composed of the fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR; also known as cluster of differentiation (CD) 140a) alpha and beta. PDGF is a potent mitogen for connective tissue cells. PDGF-stimulated processes are mediated by three different PDGFs (PDGF-A,PDGF-B, and PDGF-C). PDGFR alpha binds to all three PDGFs, whereas the PDGFR beta binds only to PDGF-B. PDGF alpha is organized as an extracellular component having five Ig-like domains, a transmembrane segment, and a cytoplasmic portion having protein tyrosine kinase activity. In mice, PDGFR alpha and PDGFR beta are essential for normal development.


Pssm-ID: 409445  Cd Length: 101  Bit Score: 148.47  E-value: 7.38e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  313 GYVRLLETLGDVEIAELHRSRTLRVVFEAYPMPSVLWLKDNRTLGDSgAGELVLSTRNMSETRYVSELILVRVKVSEAGY 392
Cdd:cd05859     1 GFIALKPTFGQLEFANLHEVKEFVVEVEAYPPPQIRWLKDNRTLIEN-LTEITTSTRNVQETRYVSKLKLIRAKEEDSGL 79
                          90       100
                  ....*....|....*....|..
gi 226342982  393 YTMRAFHEDDEVQLSFKLQVNV 414
Cdd:cd05859    80 YTALAQNEDAVKSYTFALQIQV 101
IgI_PDGFR-alphabeta cd05861
Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha ...
211-309 1.11e-40

Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha and beta; member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (also known as cluster of differentiation (CD) 140a), and beta (also known as CD140b). PDGF is a potent mitogen for connective tissue cells. PDGF-stimulated processes are mediated by three different PDGFs (PDGF-A,PDGF-B, and PDGF-C). PDGFRalpha binds to all three PDGFs, whereas the PDGFRbeta binds only to PDGF-B. PDGFRs alpha and beta have similar organization: an extracellular component with five Ig-like domains, a transmembrane segment, and a cytoplasmic portion having protein tyrosine kinase activity. In mice, PDGFRalpha and PDGFRbeta are essential for normal development.


Pssm-ID: 409447  Cd Length: 99  Bit Score: 145.05  E-value: 1.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  211 SSINVSVNAVQTVVRQGESITIRCIVMGNDVVNFQWTYPRMKSGRLVEPVTDYLfgVPS-RIGSILHIPTAELSDSGTYT 289
Cdd:cd05861     1 SSINVEMEAVKTVVRQGETITLMCIVIGNEVVDLEWTYPGKESGRGIEPVEEFK--VPPyHLVYTLTIPSATLEDSGTYE 78
                          90       100
                  ....*....|....*....|
gi 226342982  290 CNVSVSVNDHGDEKAINISV 309
Cdd:cd05861    79 CAVTEATNDHQDEKKINITV 98
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
601-905 1.30e-16

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 84.29  E-value: 1.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  601 VLGRTLGSGAFGQVVEATAHGLSHsqatmKVAVKMLKSTARSSEK--QALMSELKIMSHLGpHLNVVNLLGACTKGGPIY 678
Cdd:COG0515    10 RILRLLGRGGMGVVYLARDLRLGR-----PVALKVLRPELAADPEarERFRREARALARLN-HPNIVRVYDVGEEDGRPY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  679 IITEYCRYGDLVDYLHRNKhtflqrhsnkhcppsaelysnALPVgfslpshlnltgesdggymdmskDESIDYVpmldmk 758
Cdd:COG0515    84 LVMEYVEGESLADLLRRRG---------------------PLPP-----------------------AEALRIL------ 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  759 gdikyadiespsymapydnyvpsapertyratlindspvlsytdlvgfsYQVANGMDFLASKNCVHRDLAARNVLICEGK 838
Cdd:COG0515   114 -------------------------------------------------AQLAEALAAAHAAGIVHRDIKPANILLTPDG 144
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226342982  839 LVKICDFGLARdIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYP 905
Cdd:COG0515   145 RVKLIDFGIAR-ALGGATLTQTGTVVGTPGYMAPEQARGEPVDPRSDVYSLGVTLYELLT-GRPPFD 209
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
36-113 1.29e-10

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 58.75  E-value: 1.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    36 PPGPEFVLNISSTFVLTCSGS-----APVMWEQMSQVP--WQEAAMNQDGTFSSVLTLTNVTGGDTGEYFCVYNNSLGPE 108
Cdd:pfam00047    1 SAPPTVTVLEGDSATLTCSAStgspgPDVTWSKEGGTLieSLKVKHDNGRTTQSSLLISNVTKEDAGTYTCVVNNPGGSA 80

                   ....*
gi 226342982   109 LSERK 113
Cdd:pfam00047   81 TLSTS 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
215-293 2.64e-10

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 57.58  E-value: 2.64e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226342982   215 VSVNAVQTVVRQGESITIRCIVMGNDVVNFQWTyprmKSGRLVEPVTDYLFGVpSRIGSILHIPTAELSDSGTYTCNVS 293
Cdd:pfam13927    4 ITVSPSSVTVREGETVTLTCEATGSPPPTITWY----KNGEPISSGSTRSRSL-SGSNSTLTISNVTRSDAGTYTCVAS 77
PLN00034 PLN00034
mitogen-activated protein kinase kinase; Provisional
790-1001 2.93e-10

mitogen-activated protein kinase kinase; Provisional


Pssm-ID: 215036 [Multi-domain]  Cd Length: 353  Bit Score: 63.30  E-value: 2.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  790 TLINDSPVLSytDLvgfSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLAR---DIMRDSNyiskgSTFLP 866
Cdd:PLN00034  162 THIADEQFLA--DV---ARQILSGIAYLHRRHIVHRDIKPSNLLINSAKNVKIADFGVSRilaQTMDPCN-----SSVGT 231
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  867 LKWMAPESIFNSLYTTL-----SDVWSFGILLWEiFTLGGTPYPELPMNDqfYNAIKRGYRMAQ----PAHASDEIYEIM 937
Cdd:PLN00034  232 IAYMSPERINTDLNHGAydgyaGDIWSLGVSILE-FYLGRFPFGVGRQGD--WASLMCAICMSQppeaPATASREFRHFI 308
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  938 QKCWEEKFETRPPFSQLVlllerllgegykkkyqqvdeeflrsDHPAILRSQARF----PGIHSLRSP 1001
Cdd:PLN00034  309 SCCLQREPAKRWSAMQLL-------------------------QHPFILRAQPGQgqggPNLHQLLPP 351
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
221-309 7.57e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.66  E-value: 7.57e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    221 QTVVRQGESITIRCIVMGNDVVNFQWTYPRmksGRLVEPVTDYLfGVPSRIGSILHIPTAELSDSGTYTCNVSvsvNDHG 300
Cdd:smart00410    3 SVTVKEGESVTLSCEASGSPPPEVTWYKQG---GKLLAESGRFS-VSRSGSTSTLTISNVTPEDSGTYTCAAT---NSSG 75
                            90
                    ....*....|
gi 226342982    301 DEKA-INISV 309
Cdd:smart00410   76 SASSgTTLTV 85
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
791-904 3.32e-06

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 50.95  E-value: 3.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  791 LINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI----MRDSN-------YIS 859
Cdd:NF033483   97 YIREHGPLSPEEAVEIMIQILSALEHAHRNGIVHRDIKPQNILITKDGRVKVTDFGIARALssttMTQTNsvlgtvhYLS 176
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 226342982  860 kgstflplkwmaPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPY 904
Cdd:NF033483  177 ------------PEQARGGTVDARSDIYSLGIVLYEMLT-GRPPF 208
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
49-106 3.21e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 40.01  E-value: 3.21e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982   49 FVLTCSGSAP----VMWE-QMSQVPWQEAAMNQDGTFSSVLTLTNVTGGDTGEYFCVYNNSLG 106
Cdd:cd00096     1 VTLTCSASGNppptITWYkNGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAG 63
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
334-394 6.02e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.47  E-value: 6.02e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226342982   334 TLRVVFEAYPMPSVLWLKDNRTLGDSgagelvlSTRNMSETRYVSELILVRVKVSEAGYYT 394
Cdd:pfam13927   20 TLTCEATGSPPPTITWYKNGEPISSG-------STRSRSLSGSNSTLTISNVTRSDAGTYT 73
 
Name Accession Description Interval E-value
PTKc_PDGFR_beta cd05107
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; ...
562-953 0e+00

Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. PDGFR beta is a receptor PTK (RTK) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR beta forms homodimers or heterodimers with PDGFR alpha, depending on the nature of the PDGF ligand. PDGF-BB and PDGF-DD induce PDGFR beta homodimerization. PDGFR signaling plays many roles in normal embryonic development and adult physiology. PDGFR beta signaling leads to a variety of cellular effects including the stimulation of cell growth and chemotaxis, as well as the inhibition of apoptosis and GAP junctional communication. It is critical in normal angiogenesis as it is involved in the recruitment of pericytes and smooth muscle cells essential for vessel stability. Aberrant PDGFR beta expression is associated with some human cancers. The continuously-active fusion proteins of PDGFR beta with COL1A1 and TEL are associated with dermatofibrosarcoma protuberans (DFSP) and a subset of chronic myelomonocytic leukemia (CMML), respectively. The PDGFR beta subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133238 [Multi-domain]  Cd Length: 401  Bit Score: 851.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  562 YEIRWKVIESVSSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTAR 641
Cdd:cd05107     1 YEIRWKVIESVSSDGHEYIYVDPMQLPYDSAWEMPRDNLVLGRTLGSGAFGRVVEATAHGLSHSQSTMKVAVKMLKSTAR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  642 SSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSaELYSNALP 721
Cdd:cd05107    81 SSEKQALMSELKIMSHLGPHLNIVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQYYLDKNRDDG-SLISGGST 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  722 VGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRATLINDSPVLSYT 801
Cdd:cd05107   160 PLSQRKSHVSLGSESDGGYMDMSKDESADYVPMQDMKGTVKYADIESSNYESPYDQYLPSAPERTRRDTLINESPALSYM 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  802 DLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYT 881
Cdd:cd05107   240 DLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNNLYT 319
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  882 TLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05107   320 TLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAKPAHASDEIYEIMQKCWEEKFEIRPDFSQ 391
PTKc_PDGFR_alpha cd05105
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha; ...
562-951 0e+00

Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. PDGFR alpha is a receptor PTK (RTK) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR alpha forms homodimers or heterodimers with PDGFR beta, depending on the nature of the PDGF ligand. PDGF-AA, PDGF-AB, and PDGF-CC induce PDGFR alpha homodimerization. PDGFR signaling plays many roles in normal embryonic development and adult physiology. PDGFR alpha signaling is important in the formation of lung alveoli, intestinal villi, mesenchymal dermis, and hair follicles, as well as in the development of oligodendrocytes, retinal astrocytes, neural crest cells, and testicular cells. Aberrant PDGFR alpha expression is associated with some human cancers. Mutations in PDGFR alpha have been found within a subset of gastrointestinal stromal tumors (GISTs). An active fusion protein FIP1L1-PDGFR alpha, derived from interstitial deletion, is associated with idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia. The PDGFR alpha subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173653 [Multi-domain]  Cd Length: 400  Bit Score: 592.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  562 YEIRWKVIESVSSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTAR 641
Cdd:cd05105     1 YEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTAR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  642 SSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKhcpPSAELYSNAL- 720
Cdd:cd05105    81 SSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDNFLSRHPEK---PKKDLDIFGIn 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  721 PVGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNyvPSAPERTYRATLIND-SPVLS 799
Cdd:cd05105   158 PADESTRSYVILSFENKGDYMDMKQADTTQYVPMLEIKEASKYSDIQRSNYDRPASY--KGSNDSEVKNLLSDDgSEGLT 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  800 YTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSL 879
Cdd:cd05105   236 TLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNL 315
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  880 YTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05105   316 YTTLSDVWSYGILLWEIFSLGGTPYPGMIVDSTFYNKIKSGYRMAKPDHATQEVYDIMVKCWNSEPEKRPSF 387
PTKc_PDGFR cd05055
Catalytic domain of the Protein Tyrosine Kinases, Platelet Derived Growth Factor Receptors; ...
562-953 0e+00

Catalytic domain of the Protein Tyrosine Kinases, Platelet Derived Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The PDGFR subfamily consists of PDGFR alpha, PDGFR beta, KIT, CSF-1R, the mammalian FLT3, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. PDGFR kinase domains are autoinhibited by their juxtamembrane regions containing tyr residues. The binding to their ligands leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR subfamily receptors are important in the development of a variety of cells. PDGFRs are expressed in a many cells including fibroblasts, neurons, endometrial cells, mammary epithelial cells, and vascular smooth muscle cells. PDGFR signaling is critical in normal embryonic development, angiogenesis, and wound healing. Kit is important in the development of melanocytes, germ cells, mast cells, hematopoietic stem cells, the interstitial cells of Cajal, and the pacemaker cells of the GI tract. CSF-1R signaling is critical in the regulation of macrophages and osteoclasts. Mammalian FLT3 plays an important role in the survival, proliferation, and differentiation of stem cells. The PDGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 133186 [Multi-domain]  Cd Length: 302  Bit Score: 542.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  562 YEIRWKVIESVSsdGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTAR 641
Cdd:cd05055     1 YEVRWKVIESIN--GNEYVYIDPTQLPYDLKWEFPRNNLSFGKTLGAGAFGKVVEATAYGLSKSDAVMKVAVKMLKPTAH 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  642 SSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLqrhsnkhcppsaelysnalp 721
Cdd:cd05055    79 SSEREALMSELKIMSHLGNHENIVNLLGACTIGGPILVITEYCCYGDLLNFLRRKRESFL-------------------- 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  722 vgfslpshlnltgesdggymdmskdesidyvpmldmkgdikyadiespsymapydnyvpsapertyratlindspvlSYT 801
Cdd:cd05055   139 -----------------------------------------------------------------------------TLE 141
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  802 DLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYT 881
Cdd:cd05055   142 DLLSFSYQVAKGMAFLASKNCIHRDLAARNVLLTHGKIVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFNCVYT 221
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  882 TLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05055   222 FESDVWSYGILLWEIFSLGSNPYPGMPVDSKFYKLIKEGYRMAQPEHAPAEIYDIMKTCWDADPLKRPTFKQ 293
PTKc_CSF-1R cd05106
Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor; PTKs ...
559-953 3.42e-154

Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. CSF-1R, also called c-Fms, is a member of the Platelet Derived Growth Factor Receptor (PDGFR) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of CSF-1R to its ligand, CSF-1, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. CSF-1R signaling is critical in the regulation of macrophages and osteoclasts. It leads to increases in gene transcription and protein translation, and induces cytoskeletal remodeling. CSF-1R signaling leads to a variety of cellular responses including survival, proliferation, and differentiation of target cells. It plays an important role in innate immunity, tissue development and function, and the pathogenesis of some diseases including atherosclerosis and cancer. CSF-1R signaling is also implicated in mammary gland development during pregnancy and lactation. Aberrant CSF-1/CSF-1R expression correlates with tumor cell invasiveness, poor clinical prognosis, and bone metastasis in breast cancer. Although the structure of the human CSF-1R catalytic domain is known, it is excluded from this specific alignment model because it contains a deletion in its sequence. The CSF-1R subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133237 [Multi-domain]  Cd Length: 374  Bit Score: 463.55  E-value: 3.42e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  559 KPRYEIRWKVIESvsSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKS 638
Cdd:cd05106     1 KPKYEIRWKIIEA--AEGNNYTFIDPTQLPYNEKWEFPRDNLQFGKTLGAGAFGKVVEATAFGLGKEDNVLRVAVKMLKA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  639 TARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSAELysn 718
Cdd:cd05106    79 SAHTDEREALMSELKILSHLGQHKNIVNLLGACTHGGPVLVITEYCCYGDLLNFLRKKAETFLNFVMALPEISETSS--- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  719 alpvgfslpSHLNLTGE-----SDGGYMDMSKDesiDYVPMldmkgdikyadieSPSYMAPYDNYVPSAPERTyratliN 793
Cdd:cd05106   156 ---------DYKNITLEkkyirSDSGFSSQGSD---TYVEM-------------RPVSSSSSQSSDSKDEEDT------E 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  794 DSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPE 873
Cdd:cd05106   205 DSWPLDLDDLLRFSSQVAQGMDFLASKNCIHRDVAARNVLLTDGRVAKICDFGLARDIMNDSNYVVKGNARLPVKWMAPE 284
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  874 SIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05106   285 SIFDCVYTVQSDVWSYGILLWEIFSLGKSPYPGILVNSKFYKMVKRGYQMSRPDFAPPEIYSIMKMCWNLEPTERPTFSQ 364
PTKc_Kit cd05104
Catalytic domain of the Protein Tyrosine Kinase, Kit; PTKs catalyze the transfer of the ...
562-953 4.95e-151

Catalytic domain of the Protein Tyrosine Kinase, Kit; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Kit is important in the development of melanocytes, germ cells, mast cells, hematopoietic stem cells, the interstitial cells of Cajal, and the pacemaker cells of the GI tract. Kit signaling is involved in major cellular functions including cell survival, proliferation, differentiation, adhesion, and chemotaxis. Mutations in Kit, which result in constitutive ligand-independent activation, are found in human cancers such as gastrointestinal stromal tumor (GIST) and testicular germ cell tumor (TGCT). The aberrant expression of Kit and/or SCF is associated with other tumor types such as systemic mastocytosis and cancers of the breast, neurons, lung, prostate, colon, and rectum. Although the structure of the human Kit catalytic domain is known, it is excluded from this specific alignment model because it contains a deletion in its sequence. Kit is a member of the Platelet Derived Growth Factor Receptor (PDGFR) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of Kit to its ligand, the stem-cell factor (SCF), leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. The Kit subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270682 [Multi-domain]  Cd Length: 375  Bit Score: 455.13  E-value: 4.95e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  562 YEIRWKVIESVssDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTAR 641
Cdd:cd05104     1 YEIQWKVVEEI--NGNNYVYIDPTQLPYDHKWEFPRDRLRFGKTLGAGAFGKVVEATAYGLAKADSAMTVAVKMLKPSAH 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  642 SSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHcpPSAELYSNALp 721
Cdd:cd05104    79 STEREALMSELKVLSYLGNHINIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFICPKFEDL--AEAALYRNLL- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  722 vgfslpSHLNLTGESDGGYMDMSKdeSIDYVpmLDMKGDiKYADIESPSYMApyDNYVPSAPErtyratliNDSPVLSYT 801
Cdd:cd05104   156 ------HQREMACDSLNEYMDMKP--SVSYV--VPTKAD-KRRGVRSGSYVD--QDVTSEILE--------EDELALDTE 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  802 DLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYT 881
Cdd:cd05104   215 DLLSFSYQVAKGMEFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFECVYT 294
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  882 TLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05104   295 FESDVWSYGILLWEIFSLGSSPYPGMPVDSKFYKMIKEGYRMDSPEFAPSEMYDIMRSCWDADPLKRPTFKQ 366
PTKc_VEGFR cd05054
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; ...
593-953 1.32e-124

Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The VEGFR subfamily consists of VEGFR1 (Flt1), VEGFR2 (Flk1), VEGFR3 (Flt4), and similar proteins. VEGFR subfamily members are receptor PTKss (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. There are five VEGF ligands in mammals, which bind, in an overlapping pattern to the three VEGFRs, which can form homo or heterodimers. VEGFRs regulate the cardiovascular system. They are critical for vascular development during embryogenesis and blood vessel formation in adults. They induce cellular functions common to other growth factor receptors such as cell migration, survival, and proliferation. The VEGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270647 [Multi-domain]  Cd Length: 298  Bit Score: 382.99  E-value: 1.32e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACT 672
Cdd:cd05054     2 WEFPRDRLKLGKPLGRGAFGKVIQASAFGIDKSATCRTVAVKMLKEGATASEHKALMTELKILIHIGHHLNVVNLLGACT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 K-GGPIYIITEYCRYGDLVDYLHRNKHTFLqrhsnkhcppsaeLYSNALPvgfslpsHLNLTGESDGGYMdmskdesidy 751
Cdd:cd05054    82 KpGGPLMVIVEFCKFGNLSNYLRSKREEFV-------------PYRDKGA-------RDVEEEEDDDELY---------- 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  752 vpmldmkgdikyadiESPsymapydnyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARN 831
Cdd:cd05054   132 ---------------KEP----------------------------LTLEDLICYSFQVARGMEFLASRKCIHRDLAARN 168
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  832 VLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMND 911
Cdd:cd05054   169 ILLSENNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQMDE 248
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 226342982  912 QFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05054   249 EFCRRLKEGTRMRAPEYTTPEIYQIMLDCWHGEPKERPTFSE 290
PK_Tyr_Ser-Thr pfam07714
Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role ...
600-953 1.45e-118

Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyze the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyze the reverse process. Protein kinases fall into three broad classes, characterized with respect to substrate specificity; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.


Pssm-ID: 462242 [Multi-domain]  Cd Length: 258  Bit Score: 365.67  E-value: 1.45e-118
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   600 LVLGRTLGSGAFGQVVEATAHGlSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACTKGGPIYI 679
Cdd:pfam07714    1 LTLGEKLGEGAFGEVYKGTLKG-EGENTKIKVAVKTLKEGADEEEREDFLEEASIMKKL-DHPNIVKLLGVCTQGEPLYI 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   680 ITEYCRYGDLVDYLHRNKHTflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkg 759
Cdd:pfam07714   79 VTEYMPGGDLLDFLRKHKRK------------------------------------------------------------ 98
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   760 dikyadiespsymapydnyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKL 839
Cdd:pfam07714   99 --------------------------------------LTLKDLLSMALQIAKGMEYLESKNFVHRDLAARNCLVSENLV 140
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   840 VKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKR 919
Cdd:pfam07714  141 VKISDFGLSRDIYDDDYYRKRGGGKLPIKWMAPESLKDGKFTSKSDVWSFGVLLWEIFTLGEQPYPGMS-NEEVLEFLED 219
                          330       340       350
                   ....*....|....*....|....*....|....
gi 226342982   920 GYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:pfam07714  220 GYRLPQPENCPDELYDLMKQCWAYDPEDRPTFSE 253
PTKc_VEGFR1 cd14207
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; ...
593-953 3.30e-114

Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR1 (or Flt1) binds VEGFA, VEGFB, and placenta growth factor (PLGF). It regulates monocyte and macrophage migration, vascular permeability, haematopoiesis, and the recruitment of haematopietic progenitor cells from the bone marrow. VEGFR1 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271109 [Multi-domain]  Cd Length: 340  Bit Score: 357.39  E-value: 3.30e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACT 672
Cdd:cd14207     2 WEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRVVAVKMLKEGATASEYKALMTELKILIHIGHHLNVVNLLGACT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 K-GGPIYIITEYCRYGDLVDYLHRNKHTF-LQRHSNKHCPPSAElYSNALPVGF------SLPSHLNLTG---ESDGGYM 741
Cdd:cd14207    82 KsGGPLMVIVEYCKYGNLSNYLKSKRDFFvTNKDTSLQEELIKE-KKEAEPTGGkkkrleSVTSSESFASsgfQEDKSLS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  742 DMSKDEsidyvpmlDMKGDIkyadiespsYMAPydnyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKN 821
Cdd:cd14207   161 DVEEEE--------EDSGDF---------YKRP-----------------------LTMEDLISYSFQVARGMEFLSSRK 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  822 CVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGG 901
Cdd:cd14207   201 CIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDARLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGA 280
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 226342982  902 TPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14207   281 SPYPGVQIDEDFCSKLKEGIRMRAPEFATSEIYQIMLDCWQGDPNERPRFSE 332
PTKc cd00192
Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
604-953 1.47e-113

Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. They can be classified into receptor and non-receptor tyr kinases. PTKs play important roles in many cellular processes including, lymphocyte activation, epithelium growth and maintenance, metabolism control, organogenesis regulation, survival, proliferation, differentiation, migration, adhesion, motility, and morphogenesis. Receptor tyr kinases (RTKs) are integral membrane proteins which contain an extracellular ligand-binding region, a transmembrane segment, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain, leading to intracellular signaling. Some RTKs are orphan receptors with no known ligands. Non-receptor (or cytoplasmic) tyr kinases are distributed in different intracellular compartments and are usually multi-domain proteins containing a catalytic tyr kinase domain as well as various regulatory domains such as SH3 and SH2. PTKs are usually autoinhibited and require a mechanism for activation. In many PTKs, the phosphorylation of tyr residues in the activation loop is essential for optimal activity. Aberrant expression of PTKs is associated with many development abnormalities and cancers.The PTK family is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270623 [Multi-domain]  Cd Length: 262  Bit Score: 352.61  E-value: 1.47e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEATAHGLShsQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITEY 683
Cdd:cd00192     1 KKLGEGAFGEVYKGKLKGGD--GKTVDVAVKTLKEDASESERKDFLKEARVMKKLG-HPNVVRLLGVCTEEEPLYLVMEY 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  684 CRYGDLVDYLHRNKHTFLQrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgdiky 763
Cdd:cd00192    78 MEGGDLLDFLRKSRPVFPS------------------------------------------------------------- 96
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  764 adiespsymapydnyvpsapertyratliNDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKIC 843
Cdd:cd00192    97 -----------------------------PEPSTLSLKDLLSFAIQIAKGMEYLASKKFVHRDLAARNCLVGEDLVVKIS 147
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  844 DFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKRGYRM 923
Cdd:cd00192   148 DFGLSRDIYDDDYYRKKTGGKLPIRWMAPESLKDGIFTSKSDVWSFGVLLWEIFTLGATPYPGLS-NEEVLEYLRKGYRL 226
                         330       340       350
                  ....*....|....*....|....*....|
gi 226342982  924 AQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd00192   227 PKPENCPDELYELMLSCWQLDPEDRPTFSE 256
PTKc_VEGFR3 cd05102
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; ...
593-953 2.80e-113

Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR3 (or Flt4) preferentially binds the ligands VEGFC and VEGFD. VEGFR3 is essential for lymphatic endothelial cell (EC) development and function. It has been shown to regulate adaptive immunity during corneal transplantation. VEGFR3 is upregulated on blood vascular ECs in pathological conditions such as vascular tumors and the periphery of solid tumors. It plays a role in cancer progression and lymph node metastasis. Missense mutations in the VEGFR3 gene are associated with primary human lymphedema. VEGFR3 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270680 [Multi-domain]  Cd Length: 336  Bit Score: 354.67  E-value: 2.80e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACT 672
Cdd:cd05102     2 WEFPRDRLRLGKVLGHGAFGKVVEASAFGIDKSSSCETVAVKMLKEGATASEHKALMSELKILIHIGNHLNVVNLLGACT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 K-GGPIYIITEYCRYGDLVDYLHRNKHTFLQrhsnkhcppsaelysnalpvgfslpshlnltgesdggYMDMSKDESIDY 751
Cdd:cd05102    82 KpNGPLMVIVEFCKYGNLSNFLRAKREGFSP-------------------------------------YRERSPRTRSQV 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  752 VPMLDMKgdikYADIESPSYMAPYDNYVPSAPERTYRATLIND---SPvLSYTDLVGFSYQVANGMDFLASKNCVHRDLA 828
Cdd:cd05102   125 RSMVEAV----RADRRSRQGSDRVASFTESTSSTNQPRQEVDDlwqSP-LTMEDLICYSFQVARGMEFLASRKCIHRDLA 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  829 ARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELP 908
Cdd:cd05102   200 ARNILLSENNVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQ 279
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 226342982  909 MNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05102   280 INEEFCQRLKDGTRMRAPEYATPEIYRIMLSCWHGDPKERPTFSD 324
PTKc_VEGFR2 cd05103
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; ...
593-953 2.94e-113

Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR2 (or Flk1) binds the ligands VEGFA, VEGFC, VEGFD and VEGFE. VEGFR2 signaling is implicated in all aspects of normal and pathological vascular endothelial cell biology. It induces a variety of cellular effects including migration, survival, and proliferation. It is critical in regulating embryonic vascular development and angiogenesis. VEGFR2 is the major signal transducer in pathological angiogenesis including cancer and diabetic retinopathy, and is a target for inhibition in cancer therapy. The carboxyl terminus of VEGFR2 plays an important role in its autophosphorylation and activation. VEGFR2 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270681 [Multi-domain]  Cd Length: 343  Bit Score: 355.06  E-value: 2.94e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACT 672
Cdd:cd05103     2 WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 K-GGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSAELYSNALPVGFS--LPSHLNLTGESDGGYMDmskdesi 749
Cdd:cd05103    82 KpGGPLMVIVEFCKFGNLSAYLRSKRSEFVPYKTKGARFRQGKDYVGDISVDLKrrLDSITSSQSSASSGFVE------- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  750 dyvpmldmkgDIKYADIESPSymapydnyvpSAPERTYRAtlindspVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAA 829
Cdd:cd05103   155 ----------EKSLSDVEEEE----------AGQEDLYKD-------FLTLEDLICYSFQVAKGMEFLASRKCIHRDLAA 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  830 RNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPM 909
Cdd:cd05103   208 RNILLSENNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKI 287
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 226342982  910 NDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05103   288 DEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSE 331
PTKc_FGFR cd05053
Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs ...
587-953 6.74e-110

Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The FGFR subfamily consists of FGFR1, FGFR2, FGFR3, FGFR4, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, and to heparin/heparan sulfate (HS) results in the formation of a ternary complex, which leads to receptor dimerization and activation, and intracellular signaling. There are at least 23 FGFs and four types of FGFRs. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. FGF/FGFR signaling is important in the regulation of embryonic development, homeostasis, and regenerative processes. Depending on the cell type and stage, FGFR signaling produces diverse cellular responses including proliferation, growth arrest, differentiation, and apoptosis. Aberrant signaling leads to many human diseases such as skeletal, olfactory, and metabolic disorders, as well as cancer. The FGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 270646 [Multi-domain]  Cd Length: 294  Bit Score: 344.02  E-value: 6.74e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  587 LPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQA-TMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVV 665
Cdd:cd05053     1 LPLDPEWELPRDRLTLGKPLGEGAFGQVVKAEAVGLDNKPNeVVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNII 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  666 NLLGACTKGGPIYIITEYCRYGDLVDYLHRNKhtflqrhsnkhcpPSAELYSNALPvgfslpshlnltgesdggymdmsk 745
Cdd:cd05053    81 NLLGACTQDGPLYVVVEYASKGNLREFLRARR-------------PPGEEASPDDP------------------------ 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  746 desidyvpmldmkgdikyadiespsymapydnyvpsapertyratlINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHR 825
Cdd:cd05053   124 ----------------------------------------------RVPEEQLTQKDLVSFAYQVARGMEYLASKKCIHR 157
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  826 DLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYP 905
Cdd:cd05053   158 DLAARNVLVTEDNVMKIADFGLARDIHHIDYYRKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYP 237
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 226342982  906 ELPMnDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05053   238 GIPV-EELFKLLKEGHRMEKPQNCTQELYMLMRDCWHEVPSQRPTFKQ 284
STYKc smart00221
Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class ...
600-953 2.24e-106

Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase.


Pssm-ID: 214568 [Multi-domain]  Cd Length: 258  Bit Score: 333.36  E-value: 2.24e-106
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    600 LVLGRTLGSGAFGQVVEATAHGLSHSQaTMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYI 679
Cdd:smart00221    1 LTLGKKLGEGAFGEVYKGTLKGKGDGK-EVEVAVKTLKEDASEQQIEEFLREARIMRKLD-HPNIVKLLGVCTEEEPLMI 78
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    680 ITEYCRYGDLVDYLHRNKHTFLqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkg 759
Cdd:smart00221   79 VMEYMPGGDLLDYLRKNRPKEL---------------------------------------------------------- 100
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    760 dikyadiespsymapydnyvpsapertyratlindspvlSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKL 839
Cdd:smart00221  101 ---------------------------------------SLSDLLSFALQIARGMEYLESKNFIHRDLAARNCLVGENLV 141
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    840 VKICDFGLARDIMRDSNYISKGSTfLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKR 919
Cdd:smart00221  142 VKISDFGLSRDLYDDDYYKVKGGK-LPIRWMAPESLKEGKFTSKSDVWSFGVLLWEIFTLGEEPYPGMS-NAEVLEYLKK 219
                           330       340       350
                    ....*....|....*....|....*....|....
gi 226342982    920 GYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:smart00221  220 GYRLPKPPNCPPELYKLMLQCWAEDPEDRPTFSE 253
TyrKc smart00219
Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.
600-953 1.67e-105

Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.


Pssm-ID: 197581 [Multi-domain]  Cd Length: 257  Bit Score: 331.03  E-value: 1.67e-105
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    600 LVLGRTLGSGAFGQVVEATAHGLSHSQaTMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYI 679
Cdd:smart00219    1 LTLGKKLGEGAFGEVYKGKLKGKGGKK-KVEVAVKTLKEDASEQQIEEFLREARIMRKLD-HPNVVKLLGVCTEEEPLYI 78
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    680 ITEYCRYGDLVDYLHRNKHTflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkg 759
Cdd:smart00219   79 VMEYMEGGDLLSYLRKNRPK------------------------------------------------------------ 98
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    760 dikyadiespsymapydnyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKL 839
Cdd:smart00219   99 --------------------------------------LSLSDLLSFALQIARGMEYLESKNFIHRDLAARNCLVGENLV 140
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    840 VKICDFGLARDIMRDSnYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKR 919
Cdd:smart00219  141 VKISDFGLSRDLYDDD-YYRKRGGKLPIRWMAPESLKEGKFTSKSDVWSFGVLLWEIFTLGEQPYPGMS-NEEVLEYLKN 218
                           330       340       350
                    ....*....|....*....|....*....|....
gi 226342982    920 GYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:smart00219  219 GYRLPQPPNCPPELYDLMLQCWAEDPEDRPTFSE 252
PTKc_FGFR4 cd05099
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs ...
587-953 3.97e-90

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Unlike other FGFRs, there is only one splice form of FGFR4. It binds FGF1, FGF2, FGF6, FGF19, and FGF23. FGF19 is a selective ligand for FGFR4. Although disruption of FGFR4 in mice causes no obvious phenotype, in vivo inhibition of FGFR4 in cultured skeletal muscle cells resulted in an arrest of muscle progenitor differentiation. FGF6 and FGFR4 are uniquely expressed in myofibers and satellite cells. FGF6/FGFR4 signaling appears to play a key role in the regulation of muscle regeneration. A polymorphism in FGFR4 is found in head and neck squamous cell carcinoma. FGFR4 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133230 [Multi-domain]  Cd Length: 314  Bit Score: 291.87  E-value: 3.97e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  587 LPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQA--TMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNV 664
Cdd:cd05099     1 LPLDPKWEFPRDRLVLGKPLGEGCFGQVVRAEAYGIDKSRPdqTVTVAVKMLKDNATDKDLADLISEMELMKLIGKHKNI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  665 VNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKhtflqrhsnkhcPPSaelysnalpvgfslpshlnltgesdggyMDMS 744
Cdd:cd05099    81 INLLGVCTQEGPLYVIVEYAAKGNLREFLRARR------------PPG----------------------------PDYT 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  745 KDesidyvpmldmkgdikyadiespsymapydnyVPSAPERTyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVH 824
Cdd:cd05099   121 FD--------------------------------ITKVPEEQ-----------LSFKDLVSCAYQVARGMEYLESRRCIH 157
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  825 RDLAARNVLICEGKLVKICDFGLARDImRDSNYISKGST-FLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTP 903
Cdd:cd05099   158 RDLAARNVLVTEDNVMKIADFGLARGV-HDIDYYKKTSNgRLPVKWMAPEALFDRVYTHQSDVWSFGILMWEIFTLGGSP 236
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 226342982  904 YPELPMnDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05099   237 YPGIPV-EELFKLLREGHRMDKPSNCTHELYMLMRECWHAVPTQRPTFKQ 285
PTKc_FGFR1 cd05098
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs ...
586-953 8.58e-90

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Alternative splicing of FGFR1 transcripts produces a variety of isoforms, which are differentially expressed in cells. FGFR1 binds the ligands, FGF1 and FGF2, with high affinity and has also been reported to bind FGF4, FGF6, and FGF9. FGFR1 signaling is critical in the control of cell migration during embryo development. It promotes cell proliferation in fibroblasts. Nuclear FGFR1 plays a role in the regulation of transcription. Mutations, insertions or deletions of FGFR1 have been identified in patients with Kallman's syndrome (KS), an inherited disorder characterized by hypogonadotropic hypogonadism and loss of olfaction. Aberrant FGFR1 expression has been found in some human cancers including 8P11 myeloproliferative syndrome (EMS), breast cancer, and pancreatic adenocarcinoma. FGFR1 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270678 [Multi-domain]  Cd Length: 302  Bit Score: 290.76  E-value: 8.58e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  586 QLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQAT--MKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLN 663
Cdd:cd05098     1 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNrvTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  664 VVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKhtflqrhsnkhcPPSAELYSNalpvgfslPSHLnltgesdggymdm 743
Cdd:cd05098    81 IINLLGACTQDGPLYVIVEYASKGNLREYLQARR------------PPGMEYCYN--------PSHN------------- 127
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  744 skdesidyvpmldmkgdikyadiespsymapydnyvpsaPERTyratlindspvLSYTDLVGFSYQVANGMDFLASKNCV 823
Cdd:cd05098   128 ---------------------------------------PEEQ-----------LSSKDLVSCAYQVARGMEYLASKKCI 157
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  824 HRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTP 903
Cdd:cd05098   158 HRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 237
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 226342982  904 YPELPMnDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05098   238 YPGVPV-EELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 286
PTKc_FGFR2 cd05101
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs ...
582-953 1.52e-85

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. There are many splice variants of FGFR2 which show differential expression and binding to FGF ligands. Disruption of either FGFR2 or FGFR2b is lethal in mice, due to defects in the placenta or severe impairment of tissue development including lung, limb, and thyroid, respectively. Disruption of FGFR2c in mice results in defective bone and skull development. Genetic alterations of FGFR2 are associated with many human skeletal disorders including Apert syndrome, Crouzon syndrome, Jackson-Weiss syndrome, and Pfeiffer syndrome. FGFR2 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270679 [Multi-domain]  Cd Length: 313  Bit Score: 279.59  E-value: 1.52e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  582 VDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHS--QATMKVAVKMLKSTARSSEKQALMSELKIMSHLG 659
Cdd:cd05101     8 VSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDkpKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  660 PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKhtflqrhsnkhcPPSAElYSnalpvgfslpshlnltgesdgg 739
Cdd:cd05101    88 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR------------PPGME-YS---------------------- 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  740 ymdmskdesidyvpmldmkgdikyadiespsymapYD-NYVPSAPertyratlindspvLSYTDLVGFSYQVANGMDFLA 818
Cdd:cd05101   133 -----------------------------------YDiNRVPEEQ--------------MTFKDLVSCTYQLARGMEYLA 163
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  819 SKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT 898
Cdd:cd05101   164 SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 243
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  899 LGGTPYPELPMnDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05101   244 LGGSPYPGIPV-EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQ 297
PTKc_FGFR3 cd05100
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs ...
587-953 8.45e-81

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Many FGFR3 splice variants have been reported with the IIIb and IIIc isoforms being the predominant forms. FGFR3 IIIc is the isoform expressed in chondrocytes, the cells affected in dwarfism, while IIIb is expressed in epithelial cells. FGFR3 ligands include FGF1, FGF2, FGF4, FGF8, FGF9, and FGF23. It is a negative regulator of long bone growth. In the cochlear duct and in the lens, FGFR3 is involved in differentiation while it appears to have a role in cell proliferation in epithelial cells. Germline mutations in FGFR3 are associated with skeletal disorders including several forms of dwarfism. Some missense mutations are associated with multiple myeloma and carcinomas of the bladder and cervix. Overexpression of FGFR3 is found in thyroid carcinoma. FGFR3 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173652 [Multi-domain]  Cd Length: 334  Bit Score: 267.27  E-value: 8.45e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  587 LPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQAT--MKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNV 664
Cdd:cd05100     1 LPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDKPNkpVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  665 VNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKhtflqrhsnkhcPPSaelysnalpvgfslpshlnltgesdggyMDMS 744
Cdd:cd05100    81 INLLGACTQDGPLYVLVEYASKGNLREYLRARR------------PPG----------------------------MDYS 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  745 KDESidyvpmldmkgdikyadiespsymapydnyvpSAPERTyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVH 824
Cdd:cd05100   121 FDTC--------------------------------KLPEEQ-----------LTFKDLVSCAYQVARGMEYLASQKCIH 157
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  825 RDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPY 904
Cdd:cd05100   158 RDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 237
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 226342982  905 PELPMnDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05100   238 PGIPV-EELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFKQ 285
PTKc_RET cd05045
Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs ...
599-952 5.95e-80

Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. RET is a receptor PTK (RTK) containing an extracellular region with four cadherin-like repeats, a calcium-binding site, and a cysteine-rich domain, a transmembrane segment, and an intracellular catalytic domain. It is part of a multisubunit complex that binds glial-derived neurotropic factor (GDNF) family ligands (GFLs) including GDNF, neurturin, artemin, and persephin. GFLs bind RET along with four GPI-anchored coreceptors, bringing two RET molecules together, leading to autophosphorylation, activation, and intracellular signaling. RET is essential for the development of the sympathetic, parasympathetic and enteric nervous systems, and the kidney. RET disruption by germline mutations causes diseases in humans including congenital aganglionosis of the gastrointestinal tract (Hirschsprung's disease) and three related inherited cancers: multiple endocrine neoplasia type 2A (MEN2A), MEN2B, and familial medullary thyroid carcinoma. The RET subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173631 [Multi-domain]  Cd Length: 290  Bit Score: 263.36  E-value: 5.95e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  599 QLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIY 678
Cdd:cd05045     1 NLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASSSELRDLLSEFNLLKQVN-HPHVIKLYGACSQDGPLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  679 IITEYCRYGDLVDYLhrnkhtflqRHSNKhcppsaelysnalpVGfslPSHLNLTGESDGGYMDmskdesidyvpmldmk 758
Cdd:cd05045    80 LIVEYAKYGSLRSFL---------RESRK--------------VG---PSYLGSDGNRNSSYLD---------------- 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  759 gdikyADIESPsymapydnyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGK 838
Cdd:cd05045   118 -----NPDERA----------------------------LTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGR 164
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  839 LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIK 918
Cdd:cd05045   165 KMKISDFGLSRDVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIA-PERLFNLLK 243
                         330       340       350
                  ....*....|....*....|....*....|....
gi 226342982  919 RGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFS 952
Cdd:cd05045   244 TGYRMERPENCSEEMYNLMLTCWKQEPDKRPTFA 277
PTKc_Src_like cd05034
Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
604-951 7.68e-69

Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src subfamily members include Src, Lck, Hck, Blk, Lyn, Fgr, Fyn, Yrk, and Yes. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Src kinases are overexpressed in a variety of human cancers, making them attractive targets for therapy. They are also implicated in acute inflammatory responses and osteoclast function. Src, Fyn, Yes, and Yrk are widely expressed, while Blk, Lck, Hck, Fgr, and Lyn show a limited expression pattern. The Src-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270630 [Multi-domain]  Cd Length: 248  Bit Score: 230.63  E-value: 7.68e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEATAHGlshsqaTMKVAVKMLKSTARSseKQALMSELKIMSHLgPHLNVVNLLGACTKGGPIYIITEY 683
Cdd:cd05034     1 KKLGAGQFGEVWMGVWNG------TTKVAVKTLKPGTMS--PEAFLQEAQIMKKL-RHDKLVQLYAVCSDEEPIYIVTEL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  684 CRYGDLVDYLhrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltGESDGGYMDMskdesidyvpmldmkgdiky 763
Cdd:cd05034    72 MSKGSLLDYL----------------------------------------RTGEGRALRL-------------------- 91
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  764 adiespsymapydnyvpsapertyratlindspvlsyTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKIC 843
Cdd:cd05034    92 -------------------------------------PQLIDMAAQIASGMAYLESRNYIHRDLAARNILVGENNVCKVA 134
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  844 DFGLARDIMrDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKRGYRM 923
Cdd:cd05034   135 DFGLARLIE-DDEYTAREGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLYEIVTYGRVPYPGMT-NREVLEQVERGYRM 212
                         330       340
                  ....*....|....*....|....*...
gi 226342982  924 AQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05034   213 PKPPGCPDELYDIMLQCWKKEPEERPTF 240
PTKc_Csk_like cd05039
Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
593-953 3.68e-68

Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of Csk, Chk, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. They negatively regulate the activity of Src kinases that are anchored to the plasma membrane. To inhibit Src kinases, Csk and Chk are translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Chk inhibit Src kinases using a noncatalytic mechanism by simply binding to them. As negative regulators of Src kinases, Csk and Chk play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. The Csk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270635 [Multi-domain]  Cd Length: 256  Bit Score: 229.16  E-value: 3.68e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGlshsqatMKVAVKMLKSTARSseKQALMSELKIMSHLgPHLNVVNLLGACT 672
Cdd:cd05039     1 WAINKKDLKLGELIGKGEFGDVMLGDYRG-------QKVAVKCLKDDSTA--AQAFLAEASVMTTL-RHPNLVQLLGVVL 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGGPIYIITEYCRYGDLVDYLhrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgESDGgymdmskdesidyv 752
Cdd:cd05039    71 EGNGLYIVTEYMAKGSLVDYL-----------------------------------------RSRG-------------- 95
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyadiespsymapydnyvpsapertyRAtlindspVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05039    96 -----------------------------------RA-------VITRKDQLGFALDVCEGMEYLESKKFVHRDLAARNV 133
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARDimrdSNYISKGSTFlPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDq 912
Cdd:cd05039   134 LVSEDNVAKVSDFGLAKE----ASSNQDGGKL-PIKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD- 207
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05039   208 VVPHVEKGYRMEAPEGCPPEVYKVMKNCWELDPAKRPTFKQ 248
PTKc_Frk_like cd05068
Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
593-951 2.52e-65

Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Frk and Srk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Frk, also known as Rak, is specifically expressed in liver, lung, kidney, intestine, mammary glands, and the islets of Langerhans. Rodent homologs were previously referred to as GTK (gastrointestinal tyr kinase), BSK (beta-cell Src-like kinase), or IYK (intestinal tyr kinase). Studies in mice reveal that Frk is not essential for viability. It plays a role in the signaling that leads to cytokine-induced beta-cell death in Type I diabetes. It also regulates beta-cell number during embryogenesis and early in life. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Frk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270653 [Multi-domain]  Cd Length: 267  Bit Score: 221.51  E-value: 2.52e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEatahGLSHSqaTMKVAVKMLKstARSSEKQALMSELKIMSHLgPHLNVVNLLGACT 672
Cdd:cd05068     3 WEIDRKSLKLLRKLGSGQFGEVWE----GLWNN--TTPVAVKTLK--PGTMDPEDFLREAQIMKKL-RHPKLIQLYAVCT 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGGPIYIITEYCRYGDLVDYLHRNKHTflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyv 752
Cdd:cd05068    74 LEEPIYIITELMKHGSLLEYLQGKGRS----------------------------------------------------- 100
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyadiespsymapydnyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05068   101 ---------------------------------------------LQLPQLIDMAAQVASGMAYLESQNYIHRDLAARNV 135
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQ 912
Cdd:cd05068   136 LVGENNICKVADFGLARVIKVEDEYEAREGAKFPIKWTAPEAANYNRFSIKSDVWSFGILLTEIVTYGRIPYPGMT-NAE 214
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05068   215 VLQQVERGYRMPCPPNCPPQLYDIMLECWKADPMERPTF 253
PTKc_InsR_like cd05032
Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer ...
593-953 1.09e-64

Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The InsR subfamily is composed of InsR, Insulin-like Growth Factor-1 Receptor (IGF-1R), and similar proteins. InsR and IGF-1R are receptor PTKs (RTKs) composed of two alphabeta heterodimers. Binding of the ligand (insulin, IGF-1, or IGF-2) to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, stimulating downstream kinase activities, which initiate signaling cascades and biological function. InsR and IGF-1R, which share 84% sequence identity in their kinase domains, display physiologically distinct yet overlapping functions in cell growth, differentiation, and metabolism. InsR activation leads primarily to metabolic effects while IGF-1R activation stimulates mitogenic pathways. In cells expressing both receptors, InsR/IGF-1R hybrids are found together with classical receptors. Both receptors can interact with common adaptor molecules such as IRS-1 and IRS-2. The InsR-like subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173625 [Multi-domain]  Cd Length: 277  Bit Score: 220.29  E-value: 1.09e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHlNVVNLLGACT 672
Cdd:cd05032     1 WELPREKITLIRELGQGSFGMVYEGLAKGVVKGEPETRVAIKTVNENASMRERIEFLNEASVMKEFNCH-HVVRLLGVVS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGGPIYIITEYCRYGDLVDYL--HRNKhtflQRHSNKHCPPSAELysnalpvgfslpshlnltgesdggymdmskdesid 750
Cdd:cd05032    80 TGQPTLVVMELMAKGDLKSYLrsRRPE----AENNPGLGPPTLQK----------------------------------- 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  751 yvpMLDMKGdikyadiespsymapydnyvpsapertyratlindspvlsytdlvgfsyQVANGMDFLASKNCVHRDLAAR 830
Cdd:cd05032   121 ---FIQMAA-------------------------------------------------EIADGMAYLAAKKFVHRDLAAR 148
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  831 NVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmN 910
Cdd:cd05032   149 NCMVAEDLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTKSDVWSFGVVLWEMATLAEQPYQGLS-N 227
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 226342982  911 DQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05032   228 EEVLKFVIDGGHLDLPENCPDKLLELMRMCWQYNPKMRPTFLE 270
PTKc_c-ros cd05044
Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the ...
606-953 1.37e-62

Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily contains c-ros, Sevenless, and similar proteins. The proto-oncogene c-ros encodes an orphan receptor PTK (RTK) with an unknown ligand. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. C-ros is expressed in embryonic cells of the kidney, intestine and lung, but disappears soon after birth. It persists only in the adult epididymis. Male mice bearing inactive mutations of c-ros lack the initial segment of the epididymis and are infertile. The Drosophila protein, Sevenless, is required for the specification of the R7 photoreceptor cell during eye development. The c-ros subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270640 [Multi-domain]  Cd Length: 268  Bit Score: 213.82  E-value: 1.37e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATAHG-LSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITEYC 684
Cdd:cd05044     3 LGSGAFGEVFEGTAKDiLGDGSGETKVAVKTLRKGATDQEKAEFLKEAHLMSNFK-HPNILKLLGVCLDNDPQYIILELM 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  685 RYGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgdikya 764
Cdd:cd05044    82 EGGDLLSYLRAAR------------------------------------------------------------------- 94
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  765 diespsymapydnyvPSAPErtyratlindSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEG----KLV 840
Cdd:cd05044    95 ---------------PTAFT----------PPLLTLKDLLSICVDVAKGCVYLEDMHFVHRDLAARNCLVSSKdyreRVV 149
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  841 KICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKRG 920
Cdd:cd05044   150 KIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLVDGVFTTQSDVWAFGVLMWEILTLGQQPYPARN-NLEVLHFVRAG 228
                         330       340       350
                  ....*....|....*....|....*....|...
gi 226342982  921 YRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05044   229 GRLDQPDNCPDDLYELMLRCWSTDPEERPSFAR 261
PTKc_Trk cd05049
Catalytic domain of the Protein Tyrosine Kinases, Tropomyosin Related Kinases; PTKs catalyze ...
594-942 2.09e-60

Catalytic domain of the Protein Tyrosine Kinases, Tropomyosin Related Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Trk subfamily consists of TrkA, TrkB, TrkC, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, the nerve growth factor (NGF) family of neutrotrophins, leads to Trk receptor oligomerization and activation of the catalytic domain. Trk receptors are mainly expressed in the peripheral and central nervous systems. They play important roles in cell fate determination, neuronal survival and differentiation, as well as in the regulation of synaptic plasticity. Altered expression of Trk receptors is associated with many human diseases. The Trk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270643 [Multi-domain]  Cd Length: 280  Bit Score: 208.09  E-value: 2.09e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  594 ELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACTK 673
Cdd:cd05049     1 HIKRDTIVLKRELGEGAFGKVFLGECYNLEPEQDKMLVAVKTLKDASSPDARKDFEREAELLTNL-QHENIVKFYGVCTE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  674 GGPIYIITEYCRYGDLVDYLHRnkhtflqrhsnkHCPPSAELYSNalpvgfslpshlnltgesdggymdmskdesidyvp 753
Cdd:cd05049    80 GDPLLMVFEYMEHGDLNKFLRS------------HGPDAAFLASE----------------------------------- 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  754 mldmkgdikyadiespsymapydnyvPSAPERtyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVL 833
Cdd:cd05049   113 --------------------------DSAPGE------------LTLSQLLHIAVQIASGMVYLASQHFVHRDLATRNCL 154
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  834 ICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQF 913
Cdd:cd05049   155 VGTNLVVKIGDFGMSRDIYSTDYYRVGGHTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWFQLS-NTEV 233
                         330       340
                  ....*....|....*....|....*....
gi 226342982  914 YNAIKRGYRMAQPAHASDEIYEIMQKCWE 942
Cdd:cd05049   234 IECITQGRLLQRPRTCPSEVYAVMLGCWK 262
PTKc_Fes_like cd05041
Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; ...
604-953 8.91e-60

Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; Fes subfamily; catalytic (c) domain. Fes subfamily members include Fes (or Fps), Fer, and similar proteins. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes subfamily proteins are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated tyr kinase activity. Fes and Fer kinases play roles in haematopoiesis, inflammation and immunity, growth factor signaling, cytoskeletal regulation, cell migration and adhesion, and the regulation of cell-cell interactions. Fes and Fer show redundancy in their biological functions.


Pssm-ID: 270637 [Multi-domain]  Cd Length: 251  Bit Score: 205.37  E-value: 8.91e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEATAHGLShsqatMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITEY 683
Cdd:cd05041     1 EKIGRGNFGDVYRGVLKPDN-----TEVAVKTCRETLPPDLKRKFLQEARILKQYD-HPNIVKLIGVCVQKQPIMIVMEL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  684 CRYGDLVDYLHRNKhtflqrhsnkhcppsaelysNALPVGfslpshlnltgesdggymdmskdesidyvpmldmkgdiky 763
Cdd:cd05041    75 VPGGSLLTFLRKKG--------------------ARLTVK---------------------------------------- 94
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  764 adiespsymapydnyvpsapertyratlindspvlsytDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKIC 843
Cdd:cd05041    95 --------------------------------------QLLQMCLDAAAGMEYLESKNCIHRDLAARNCLVGENNVLKIS 136
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  844 DFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKRGYRM 923
Cdd:cd05041   137 DFGMSREEEDGEYTVSDGLKQIPIKWTAPEALNYGRYTSESDVWSFGILLWEIFSLGATPYPGMS-NQQTREQIESGYRM 215
                         330       340       350
                  ....*....|....*....|....*....|
gi 226342982  924 AQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05041   216 PAPELCPEAVYRLMLQCWAYDPENRPSFSE 245
PTKc_DDR cd05051
Catalytic domain of the Protein Tyrosine Kinases, Discoidin Domain Receptors; PTKs catalyze ...
594-953 1.10e-59

Catalytic domain of the Protein Tyrosine Kinases, Discoidin Domain Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The DDR subfamily consists of homologs of mammalian DDR1, DDR2, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDRs results in a slow but sustained receptor activation. DDRs regulate cell adhesion, proliferation, and extracellular matrix remodeling. They have been linked to a variety of human cancers including breast, colon, ovarian, brain, and lung. There is no evidence showing that DDRs act as transforming oncogenes. They are more likely to play a role in the regulation of tumor growth and metastasis. The DDR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270644 [Multi-domain]  Cd Length: 297  Bit Score: 206.80  E-value: 1.10e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  594 ELPRDQLVLGRTLGSGAFGQVVEATAHGLS------------HSQATMkVAVKMLKSTARSSEKQALMSELKIMSHLGpH 661
Cdd:cd05051     1 EFPREKLEFVEKLGEGQFGEVHLCEANGLSdltsddfigndnKDEPVL-VAVKMLRPDASKNAREDFLKEVKIMSQLK-D 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  662 LNVVNLLGACTKGGPIYIITEYCRYGDLvdylhrnkHTFLQRHsnkhcppsaelysnalpvgfslpshlnltgesdggym 741
Cdd:cd05051    79 PNIVRLLGVCTRDEPLCMIVEYMENGDL--------NQFLQKH------------------------------------- 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  742 dmskdesidyvpmldmkgdikyaDIESPSYMAPYdnyvpsapertyratlindSPVLSYTDLVGFSYQVANGMDFLASKN 821
Cdd:cd05051   114 -----------------------EAETQGASATN-------------------SKTLSYGTLLYMATQIASGMKYLESLN 151
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  822 CVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGG 901
Cdd:cd05051   152 FVHRDLATRNCLVGPNYTIKIADFGMSRNLYSGDYYRIEGRAVLPIRWMAWESILLGKFTTKSDVWAFGVTLWEILTLCK 231
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226342982  902 -TPYPELpmNDQ--------FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05051   232 eQPYEHL--TDEqvienageFFRDDGMEVYLSRPPNCPKEIYELMLECWRRDEEDRPTFRE 290
PTKc_Tie cd05047
Catalytic domain of Tie Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
606-953 2.74e-59

Catalytic domain of Tie Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie proteins, consisting of Tie1 and Tie2, are receptor PTKs (RTKs) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie receptors are specifically expressed in endothelial cells and hematopoietic stem cells. The angiopoietins (Ang-1 to Ang-4) serve as ligands for Tie2, while no specific ligand has been identified for Tie1. The binding of Ang-1 to Tie2 leads to receptor autophosphorylation and activation, promoting cell migration and survival. In contrast, Ang-2 binding to Tie2 does not result in the same response, suggesting that Ang-2 may function as an antagonist. In vivo studies of Tie1 show that it is critical in vascular development. The Tie subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270641 [Multi-domain]  Cd Length: 270  Bit Score: 204.89  E-value: 2.74e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATahgLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCR 685
Cdd:cd05047     3 IGEGNFGQVLKAR---IKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  686 YGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnlTGESDggymdmskdesidyvpmldmkgdikyad 765
Cdd:cd05047    80 HGNLLDFLRKSR-----------------------------------VLETD---------------------------- 96
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  766 iesPSYmapydnyvpsAPERTYRATLindspvlSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDF 845
Cdd:cd05047    97 ---PAF----------AIANSTASTL-------SSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADF 156
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  846 GLARDimrDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNdQFYNAIKRGYRMAQ 925
Cdd:cd05047   157 GLSRG---QEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCA-ELYEKLPQGYRLEK 232
                         330       340
                  ....*....|....*....|....*...
gi 226342982  926 PAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05047   233 PLNCDDEVYDLMRQCWREKPYERPSFAQ 260
PTKc_Tie1 cd05089
Catalytic domain of the Protein Tyrosine Kinase, Tie1; Protein Tyrosine Kinase (PTK) family; ...
606-953 1.44e-58

Catalytic domain of the Protein Tyrosine Kinase, Tie1; Protein Tyrosine Kinase (PTK) family; Tie1; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie1 is a receptor tyr kinase (RTK) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie receptors are specifically expressed in endothelial cells and hematopoietic stem cells. No specific ligand has been identified for Tie1, although the angiopoietin, Ang-1, binds to Tie1 through integrins at high concentrations. In vivo studies of Tie1 show that it is critical in vascular development.


Pssm-ID: 270671 [Multi-domain]  Cd Length: 297  Bit Score: 203.69  E-value: 1.44e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATahgLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCR 685
Cdd:cd05089    10 IGEGNFGQVIKAM---IKKDGLKMNAAIKMLKEFASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAP 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  686 YGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnlTGESDggymdmskdesidyvpmldmkgdikyad 765
Cdd:cd05089    87 YGNLLDFLRKSR-----------------------------------VLETD---------------------------- 103
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  766 iesPSYmapydnyvpsAPERTYRATLindspvlSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDF 845
Cdd:cd05089   104 ---PAF----------AKEHGTASTL-------TSQQLLQFASDVAKGMQYLSEKQFIHRDLAARNVLVGENLVSKIADF 163
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  846 GLARDimrDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNdQFYNAIKRGYRMAQ 925
Cdd:cd05089   164 GLSRG---EEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCA-ELYEKLPQGYRMEK 239
                         330       340
                  ....*....|....*....|....*...
gi 226342982  926 PAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05089   240 PRNCDDEVYELMRQCWRDRPYERPPFSQ 267
PTKc_Srm_Brk cd05148
Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal ...
593-951 2.88e-57

Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (Srm) and Breast tumor kinase (Brk); PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Srm and Brk (also called protein tyrosine kinase 6) are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Brk has been found to be overexpressed in a majority of breast tumors. Src kinases in general contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr; they are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Srm and Brk however, lack the N-terminal myristylation sites. Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. The Srm/Brk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133248 [Multi-domain]  Cd Length: 261  Bit Score: 198.81  E-value: 2.88e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGLShsqatmKVAVKMLKStARSSEKQALMSELKIMSHLgPHLNVVNLLGACT 672
Cdd:cd05148     1 WERPREEFTLERKLGSGYFGEVWEGLWKNRV------RVAIKILKS-DDLLKQQDFQKEVQALKRL-RHKHLISLFAVCS 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGGPIYIITEYCRYGDLVDYLhrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltGESDGGYMDMSkdesidyv 752
Cdd:cd05148    73 VGEPVYIITELMEKGSLLAFL----------------------------------------RSPEGQVLPVA-------- 104
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyadiespsymapydnyvpsapertyratlindspvlsytDLVGFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05148   105 -------------------------------------------------SLIDMACQVAEGMAYLEEQNSIHRDLAARNI 135
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARdIMRDSNYISKgSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELpMNDQ 912
Cdd:cd05148   136 LVGEDLVCKVADFGLAR-LIKEDVYLSS-DKKIPYKWTAPEAASHGTFSTKSDVWSFGILLYEMFTYGQVPYPGM-NNHE 212
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05148   213 VYDQITAGYRMPCPAKCPQEIYKIMLECWAAEPEDRPSF 251
PTKc_ALK_LTK cd05036
Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte ...
594-952 6.64e-57

Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyr residues in protein substrates. ALK and LTK are orphan receptor PTKs (RTKs) whose ligands are not yet well-defined. ALK appears to play an important role in mammalian neural development as well as visceral muscle differentiation in Drosophila. ALK is aberrantly expressed as fusion proteins, due to chromosomal translocations, in about 60% of anaplastic large cell lymphomas (ALCLs). ALK fusion proteins are also found in rare cases of diffuse large B cell lymphomas (DLBCLs). LTK is mainly expressed in B lymphocytes and neuronal tissues. It is important in cell proliferation and survival. Transgenic mice expressing TLK display retarded growth and high mortality rate. In addition, a polymorphism in mouse and human LTK is implicated in the pathogenesis of systemic lupus erythematosus. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. They are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The ALK/LTK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270632 [Multi-domain]  Cd Length: 277  Bit Score: 198.00  E-value: 6.64e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  594 ELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKML-KSTARSSEKQALMSELkIMSHLGpHLNVVNLLGACT 672
Cdd:cd05036     2 EVPRKNLTLIRALGQGAFGEVYEGTVSGMPGDPSPLQVAVKTLpELCSEQDEMDFLMEAL-IMSKFN-HPNIVRCIGVCF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGGPIYIITEYCRYGDLvdylhrnkHTFLQRHSNKhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyv 752
Cdd:cd05036    80 QRLPRFILLELMAGGDL--------KSFLRENRPR--------------------------------------------- 106
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyadIESPSYMAPYDnyvpsapertyratlindspvlsytdLVGFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05036   107 -------------PEQPSSLTMLD--------------------------LLQLAQDVAKGCRYLEENHFIHRDIAARNC 147
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LIC---EGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPm 909
Cdd:cd05036   148 LLTckgPGRVAKIGDFGMARDIYRADYYRKGGKAMLPVKWMPPEAFLDGIFTSKTDVWSFGVLLWEIFSLGYMPYPGKS- 226
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 226342982  910 NDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFS 952
Cdd:cd05036   227 NQEVMEFVTSGGRMDPPKNCPGPVYRIMTQCWQHIPEDRPNFS 269
PTKc_Tec_like cd05059
Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
599-952 2.33e-56

Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Tec-like subfamily is composed of Tec, Btk, Bmx (Etk), Itk (Tsk, Emt), Rlk (Txk), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, some members contain the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions. Tec kinases form the second largest subfamily of nonreceptor PTKs and are expressed mainly by haematopoietic cells, although Tec and Bmx are also found in endothelial cells. B-cells express Btk and Tec, while T-cells express Itk, Txk, and Tec. Collectively, Tec kinases are expressed in a variety of myeloid cells such as mast cells, platelets, macrophages, and dendritic cells. Each Tec kinase shows a distinct cell-type pattern of expression. Tec kinases play important roles in the development, differentiation, maturation, regulation, survival, and function of B-cells and T-cells. Mutations in Btk cause the severe B-cell immunodeficiency, X-linked agammaglobulinaemia (XLA). The Tec-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173637 [Multi-domain]  Cd Length: 256  Bit Score: 195.74  E-value: 2.33e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  599 QLVLGRTLGSGAFGQVVeatahgLSHSQATMKVAVKMLKSTARSSEKqaLMSELKIMSHLGpHLNVVNLLGACTKGGPIY 678
Cdd:cd05059     5 ELTFLKELGSGQFGVVH------LGKWRGKIDVAIKMIKEGSMSEDD--FIEEAKVMMKLS-HPKLVQLYGVCTKQRPIF 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  679 IITEYCRYGDLVDYLHRNKHTFlqrhsnkhcppSAELysnalpvgfslpshlnltgesdggymdmskdesidyvpMLDMk 758
Cdd:cd05059    76 IVTEYMANGCLLNYLRERRGKF-----------QTEQ--------------------------------------LLEM- 105
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  759 gdikyadiespsymapydnyvpsapertyratlindspvlsytdlvgfSYQVANGMDFLASKNCVHRDLAARNVLICEGK 838
Cdd:cd05059   106 ------------------------------------------------CKDVCEAMEYLESNGFIHRDLAARNCLVGEQN 137
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  839 LVKICDFGLARDIMrDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIK 918
Cdd:cd05059   138 VVKVSDFGLARYVL-DDEYTSSVGTKFPVKWSPPEVFMYSKFSSKSDVWSFGVLMWEVFSEGKMPYERFS-NSEVVEHIS 215
                         330       340       350
                  ....*....|....*....|....*....|....
gi 226342982  919 RGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFS 952
Cdd:cd05059   216 QGYRLYRPHLAPTEVYTIMYSCWHEKPEERPTFK 249
PTKc_Lyn cd05072
Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the ...
593-951 4.62e-56

Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lyn subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270657 [Multi-domain]  Cd Length: 272  Bit Score: 195.65  E-value: 4.62e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGlshsqaTMKVAVKMLKSTARSSekQALMSELKIMSHLgPHLNVVNLLGACT 672
Cdd:cd05072     2 WEIPRESIKLVKKLGAGQFGEVWMGYYNN------STKVAVKTLKPGTMSV--QAFLEEANLMKTL-QHDKLVRLYAVVT 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGGPIYIITEYCRYGDLVDYLHRNkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesDGGYMDMSKdesidyv 752
Cdd:cd05072    73 KEEPIYIITEYMAKGSLLDFLKSD----------------------------------------EGGKVLLPK------- 105
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyadiespsymapydnyvpsapertyratlindspvlsytdLVGFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05072   106 --------------------------------------------------LIDFSAQIAEGMAYIERKNYIHRDLRAANV 135
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARdIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQ 912
Cdd:cd05072   136 LVSESLMCKIADFGLAR-VIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLYEIVTYGKIPYPGMS-NSD 213
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05072   214 VMSALQRGYRMPRMENCPDELYDIMKTCWKEKAEERPTF 252
PTKc_Musk cd05050
Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; PTKs catalyze the ...
594-952 1.09e-55

Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Musk is a receptor PTK (RTK) containing an extracellular region with four immunoglobulin-like domains and a cysteine-rich cluster, a transmembrane segment, and an intracellular catalytic domain. Musk is expressed and concentrated in the postsynaptic membrane in skeletal muscle. It is essential for the establishment of the neuromuscular junction (NMJ), a peripheral synapse that conveys signals from motor neurons to muscle cells. Agrin, a large proteoglycan released from motor neurons, stimulates Musk autophosphorylation and activation, leading to the clustering of acetylcholine receptors (AChRs). To date, there is no evidence to suggest that agrin binds directly to Musk. Mutations in AChR, Musk and other partners are responsible for diseases of the NMJ, such as the autoimmune syndrome myasthenia gravis. The Musk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133181 [Multi-domain]  Cd Length: 288  Bit Score: 195.05  E-value: 1.09e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  594 ELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTK 673
Cdd:cd05050     1 EYPRNNIEYVRDIGQGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFD-HPNIVKLLGVCAV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  674 GGPIYIITEYCRYGDLVDYLHRNKHTflQRHSNKHCPPSAELYSNalpvgfslpshlnltgesdggymdmskdesidyvp 753
Cdd:cd05050    80 GKPMCLLFEYMAYGDLNEFLRHRSPR--AQCSLSHSTSSARKCGL----------------------------------- 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  754 mldmkgdikyadiespsymapydnyvpsapertyratlinDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVL 833
Cdd:cd05050   123 ----------------------------------------NPLPLSCTEQLCIAKQVAAGMAYLSERKFVHRDLATRNCL 162
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  834 ICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQF 913
Cdd:cd05050   163 VGENMVVKIADFGLSRNIYSADYYKASENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGMQPYYGMA-HEEV 241
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  914 YNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFS 952
Cdd:cd05050   242 IYYVRDGNVLSCPDNCPLELYNLMRLCWSKLPSDRPSFA 280
PTKc_Abl cd05052
Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase; PTKs catalyze the transfer of ...
593-953 1.10e-55

Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Abl (or c-Abl) is a ubiquitously-expressed cytoplasmic (or nonreceptor) PTK that contains SH3, SH2, and tyr kinase domains in its N-terminal region, as well as nuclear localization motifs, a putative DNA-binding domain, and F- and G-actin binding domains in its C-terminal tail. It also contains a short autoinhibitory cap region in its N-terminus. Abl function depends on its subcellular localization. In the cytoplasm, Abl plays a role in cell proliferation and survival. In response to DNA damage or oxidative stress, Abl is transported to the nucleus where it induces apoptosis. In chronic myelogenous leukemia (CML) patients, an aberrant translocation results in the replacement of the first exon of Abl with the BCR (breakpoint cluster region) gene. The resulting BCR-Abl fusion protein is constitutively active and associates into tetramers, resulting in a hyperactive kinase sending a continuous signal. This leads to uncontrolled proliferation, morphological transformation and anti-apoptotic effects. BCR-Abl is the target of selective inhibitors, such as imatinib (Gleevec), used in the treatment of CML. Abl2, also known as ARG (Abelson-related gene), is thought to play a cooperative role with Abl in the proper development of the nervous system. The Tel-ARG fusion protein, resulting from reciprocal translocation between chromosomes 1 and 12, is associated with acute myeloid leukemia (AML). The TEL gene is a frequent fusion partner of other tyr kinase oncogenes, including Tel/Abl, Tel/PDGFRbeta, and Tel/Jak2, found in patients with leukemia and myeloproliferative disorders. The Abl subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270645 [Multi-domain]  Cd Length: 263  Bit Score: 194.18  E-value: 1.10e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATahglsHSQATMKVAVKMLKSTARSSE----KQALMSELKimshlgpHLNVVNLL 668
Cdd:cd05052     1 WEIERTDITMKHKLGGGQYGEVYEGV-----WKKYNLTVAVKTLKEDTMEVEeflkEAAVMKEIK-------HPNLVQLL 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  669 GACTKGGPIYIITEYCRYGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskDES 748
Cdd:cd05052    69 GVCTREPPFYIITEFMPYGNLLDYLRECN------------------------------------------------REE 100
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  749 IDYVPMLdmkgdikyadiespsYMAPydnyvpsapertyratlindspvlsytdlvgfsyQVANGMDFLASKNCVHRDLA 828
Cdd:cd05052   101 LNAVVLL---------------YMAT----------------------------------QIASAMEYLEKKNFIHRDLA 131
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  829 ARNVLICEGKLVKICDFGLARdIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELP 908
Cdd:cd05052   132 ARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID 210
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 226342982  909 MNDqFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05052   211 LSQ-VYELLEKGYRMERPEGCPPKVYELMRACWQWNPSDRPSFAE 254
PTKc_Ror cd05048
Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan ...
594-953 1.51e-55

Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Ror subfamily consists of Ror1, Ror2, and similar proteins. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. Ror kinases are expressed in many tissues during development. They play important roles in bone and heart formation. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Drosophila Ror is expressed only in the developing nervous system during neurite outgrowth and neuronal differentiation, suggesting a role for Drosophila Ror in neural development. More recently, mouse Ror1 and Ror2 have also been found to play an important role in regulating neurite growth in central neurons. Ror1 and Ror2 are believed to have some overlapping and redundant functions. The Ror subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270642 [Multi-domain]  Cd Length: 283  Bit Score: 194.52  E-value: 1.51e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  594 ELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACTK 673
Cdd:cd05048     1 EIPLSAVRFLEELGEGAFGKVYKGELLGPSSEESAISVAIKTLKENASPKTQQDFRREAELMSDL-QHPNIVCLLGVCTK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  674 GGPIYIITEYCRYGDLvdylhrnkHTFLQRHSnKHCPPSAElysnalpvgfslpshlnltgESDGGYMDmskdesidyvp 753
Cdd:cd05048    80 EQPQCMLFEYMAHGDL--------HEFLVRHS-PHSDVGVS--------------------SDDDGTAS----------- 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  754 mldmkgdikyadiespsymapydnyvpsapertyratlindspVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVL 833
Cdd:cd05048   120 -------------------------------------------SLDQSDFLHIAIQIAAGMEYLSSHHYVHRDLAARNCL 156
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  834 ICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQF 913
Cdd:cd05048   157 VGDGLTVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPPEAILYGKFTTESDVWSFGVVLWEIFSYGLQPYYGYS-NQEV 235
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 226342982  914 YNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05048   236 IEMIRSRQLLPCPEDCPARVYSLMVECWHEIPSRRPRFKE 275
PTKc_Fer cd05085
Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; ...
603-953 1.95e-55

Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; Fer kinase; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fer kinase is a member of the Fes subfamily of proteins which are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. Fer kinase is expressed in a wide variety of tissues, and is found to reside in both the cytoplasm and the nucleus. It plays important roles in neuronal polarization and neurite development, cytoskeletal reorganization, cell migration, growth factor signaling, and the regulation of cell-cell interactions mediated by adherens junctions and focal adhesions. Fer kinase also regulates cell cycle progression in malignant cells.


Pssm-ID: 270668 [Multi-domain]  Cd Length: 251  Bit Score: 192.91  E-value: 1.95e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  603 GRTLGSGAFGQVVEATAhglshsQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITE 682
Cdd:cd05085     1 GELLGKGNFGEVYKGTL------KDKTPVAVKTCKEDLPQELKIKFLSEARILKQYD-HPNIVKLIGVCTQRQPIYIVME 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  683 YCRYGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskDEsidyvpmldmkgdik 762
Cdd:cd05085    74 LVPGGDFLSFLRKKK------------------------------------------------DE--------------- 90
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  763 yadiespsymapydnyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKI 842
Cdd:cd05085    91 -----------------------------------LKTKQLVKFSLDAAAGMAYLESKNCIHRDLAARNCLVGENNALKI 135
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  843 CDFGLARDiMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELpMNDQFYNAIKRGYR 922
Cdd:cd05085   136 SDFGMSRQ-EDDGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGM-TNQQAREQVEKGYR 213
                         330       340       350
                  ....*....|....*....|....*....|.
gi 226342982  923 MAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05085   214 MSAPQRCPEDIYKIMQRCWDYNPENRPKFSE 244
PTKc_TrkA cd05092
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze ...
597-948 1.14e-52

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkA is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkA to its ligand, nerve growth factor (NGF), results in receptor oligomerization and activation of the catalytic domain. TrkA is expressed mainly in neural-crest-derived sensory and sympathetic neurons of the peripheral nervous system, and in basal forebrain cholinergic neurons of the central nervous system. It is critical for neuronal growth, differentiation and survival. Alternative TrkA splicing has been implicated as a pivotal regulator of neuroblastoma (NB) behavior. Normal TrkA expression is associated with better NB prognosis, while the hypoxia-regulated TrkAIII splice variant promotes NB pathogenesis and progression. Aberrant TrkA expression has also been demonstrated in non-neural tumors including prostate, breast, lung, and pancreatic cancers. The TrkA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270674 [Multi-domain]  Cd Length: 280  Bit Score: 186.33  E-value: 1.14e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  597 RDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKStARSSEKQALMSELKIMSHLgPHLNVVNLLGACTKGGP 676
Cdd:cd05092     4 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ATESARQDFQREAELLTVL-QHQHIVRFYGVCTEGEP 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  677 IYIITEYCRYGDLvdylhrnkHTFLQRHSnkhcpPSAELYSNalpvgfslpshlnltgesdggymdmskdesidyvpmld 756
Cdd:cd05092    82 LIMVFEYMRHGDL--------NRFLRSHG-----PDAKILDG-------------------------------------- 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  757 mkgdikyadiespSYMAPYDNyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICE 836
Cdd:cd05092   111 -------------GEGQAPGQ--------------------LTLGQMLQIASQIASGMVYLASLHFVHRDLATRNCLVGQ 157
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  837 GKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNA 916
Cdd:cd05092   158 GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDIWSFGVVLWEIFTYGKQPWYQLS-NTEAIEC 236
                         330       340       350
                  ....*....|....*....|....*....|..
gi 226342982  917 IKRGYRMAQPAHASDEIYEIMQKCWEEKFETR 948
Cdd:cd05092   237 ITQGRELERPRTCPPEVYAIMQGCWQREPQQR 268
STKc_MAP3K-like cd13999
Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine ...
606-953 2.01e-52

Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed mainly of MAP3Ks and similar proteins, including TGF-beta Activated Kinase-1 (TAK1, also called MAP3K7), MAP3K12, MAP3K13, Mixed lineage kinase (MLK), MLK-Like mitogen-activated protein Triple Kinase (MLTK), and Raf (Rapidly Accelerated Fibrosarcoma) kinases. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Also included in this subfamily is the pseudokinase Kinase Suppressor of Ras (KSR), which is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway.


Pssm-ID: 270901 [Multi-domain]  Cd Length: 245  Bit Score: 184.28  E-value: 2.01e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATAHGLshsqatmKVAVKMLK-STARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITEYC 684
Cdd:cd13999     1 IGSGSFGEVYKGKWRGT-------DVAIKKLKvEDDNDELLKEFRREVSILSKLR-HPNIVQFIGACLSPPPLCIVTEYM 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  685 RYGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgdikya 764
Cdd:cd13999    73 PGGSLYDLLHKKK------------------------------------------------------------------- 85
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  765 diespsymapydnyvpsapertyratlindsPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICD 844
Cdd:cd13999    86 -------------------------------IPLSWSLRLKIALDIARGMNYLHSPPIIHRDLKSLNILLDENFTVKIAD 134
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  845 FGLARdIMRDSNYISKGS--TFlplKWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYR 922
Cdd:cd13999   135 FGLSR-IKNSTTEKMTGVvgTP---RWMAPEVLRGEPYTEKADVYSFGIVLWELLT-GEVPFKELSPIQIAAAVVQKGLR 209
                         330       340       350
                  ....*....|....*....|....*....|.
gi 226342982  923 MAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd13999   210 PPIPPDCPPELSKLIKRCWNEDPEKRPSFSE 240
PTKc_Lck_Blk cd05067
Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs ...
593-951 1.17e-51

Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lck and Blk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lck is expressed in T-cells and natural killer cells. It plays a critical role in T-cell maturation, activation, and T-cell receptor (TCR) signaling. Lck phosphorylates ITAM (immunoreceptor tyr activation motif) sequences on several subunits of TCRs, leading to the activation of different second messenger cascades. Phosphorylated ITAMs serve as binding sites for other signaling factor such as Syk and ZAP-70, leading to their activation and propagation of downstream events. In addition, Lck regulates drug-induced apoptosis by interfering with the mitochondrial death pathway. The apototic role of Lck is independent of its primary function in T-cell signaling. Blk is expressed specifically in B-cells. It is involved in pre-BCR (B-cell receptor) signaling. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lck/Blk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270652 [Multi-domain]  Cd Length: 264  Bit Score: 182.78  E-value: 1.17e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVveatahGLSHSQATMKVAVKMLKSTARSSEkqALMSELKIMSHLgPHLNVVNLLGACT 672
Cdd:cd05067     2 WEVPRETLKLVERLGAGQFGEV------WMGYYNGHTKVAIKSLKQGSMSPD--AFLAEANLMKQL-QHQRLVRLYAVVT 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGgPIYIITEYCRYGDLVDYLHrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgESDGGYMDMSKdesidyv 752
Cdd:cd05067    73 QE-PIYIITEYMENGSLVDFLK----------------------------------------TPSGIKLTINK------- 104
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pMLDMkgdikyadiespsymapydnyvpsapertyratlindspvlsytdlvgfSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05067   105 -LLDM-------------------------------------------------AAQIAEGMAFIEERNYIHRDLRAANI 134
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARdIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELpMNDQ 912
Cdd:cd05067   135 LVSDTLSCKIADFGLAR-LIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPE 212
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05067   213 VIQNLERGYRMPRPDNCPEELYQLMRLCWKERPEDRPTF 251
PTKc_EGFR_like cd05057
Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs ...
594-953 1.42e-51

Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER, ErbB) subfamily members include EGFR (HER1, ErbB1), HER2 (ErbB2), HER3 (ErbB3), HER4 (ErbB4), and similar proteins. They are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, resulting in the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Collectively, they can recognize a variety of ligands including EGF, TGFalpha, and neuregulins, among others. All four subfamily members can form homo- or heterodimers. HER3 contains an impaired kinase domain and depends on its heterodimerization partner for activation. EGFR subfamily members are involved in signaling pathways leading to a broad range of cellular responses including cell proliferation, differentiation, migration, growth inhibition, and apoptosis. Gain of function alterations, through their overexpression, deletions, or point mutations in their kinase domains, have been implicated in various cancers. These receptors are targets of many small molecule inhibitors and monoclonal antibodies used in cancer therapy. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270648 [Multi-domain]  Cd Length: 279  Bit Score: 183.00  E-value: 1.42e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  594 ELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSqATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTk 673
Cdd:cd05057     3 IVKETELEKGKVLGSGAFGTVYKGVWIPEGEK-VKIPVAIKVLREETGPKANEEILDEAYVMASVD-HPHLVRLLGICL- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  674 GGPIYIITEYCRYGDLVDYLHRNKhtflqrhsnkhcppsAELYSNALpvgfslpshLNltgesdggymdmskdesidyvp 753
Cdd:cd05057    80 SSQVQLITQLMPLGCLLDYVRNHR---------------DNIGSQLL---------LN---------------------- 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  754 mldmkgdikyadiespsymapydnyvpsapertyratlindspvlsytdlvgFSYQVANGMDFLASKNCVHRDLAARNVL 833
Cdd:cd05057   114 ----------------------------------------------------WCVQIAKGMSYLEEKRLVHRDLAARNVL 141
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  834 ICEGKLVKICDFGLARDIMRDSN-YISKGSTfLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDq 912
Cdd:cd05057   142 VKTPNHVKITDFGLAKLLDVDEKeYHAEGGK-VPIKWMALESIQYRIYTHKSDVWSYGVTVWELMTFGAKPYEGIPAVE- 219
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05057   220 IPDLLEKGERLPQPPICTIDVYMVLVKCWMIDAESRPTFKE 260
PTKc_Tie2 cd05088
Catalytic domain of the Protein Tyrosine Kinase, Tie2; PTKs catalyze the transfer of the ...
606-953 2.87e-51

Catalytic domain of the Protein Tyrosine Kinase, Tie2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie2 is a receptor PTK (RTK) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie2 is expressed mainly in endothelial cells and hematopoietic stem cells. It is also found in a subset of tumor-associated monocytes and eosinophils. The angiopoietins (Ang-1 to Ang-4) serve as ligands for Tie2. The binding of Ang-1 to Tie2 leads to receptor autophosphorylation and activation, promoting cell migration and survival. In contrast, Ang-2 binding to Tie2 does not result in the same response, suggesting that Ang-2 may function as an antagonist. Tie2 signaling plays key regulatory roles in vascular integrity and quiescence, and in inflammation. The Tie2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133219 [Multi-domain]  Cd Length: 303  Bit Score: 182.89  E-value: 2.87e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATahgLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCR 685
Cdd:cd05088    15 IGEGNFGQVLKAR---IKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAP 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  686 YGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnlTGESDGGYMDMSKDESidyvpmldmkgdikyad 765
Cdd:cd05088    92 HGNLLDFLRKSR-----------------------------------VLETDPAFAIANSTAS----------------- 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  766 iespsymapydnyvpsapertyratlindspVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDF 845
Cdd:cd05088   120 -------------------------------TLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADF 168
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  846 GLARDimrDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNdQFYNAIKRGYRMAQ 925
Cdd:cd05088   169 GLSRG---QEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCA-ELYEKLPQGYRLEK 244
                         330       340
                  ....*....|....*....|....*...
gi 226342982  926 PAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05088   245 PLNCDDEVYDLMRQCWREKPYERPSFAQ 272
PTKc_Met_Ron cd05058
Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; PTKs catalyze the transfer of ...
802-953 3.61e-50

Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Met and Ron are receptor PTKs (RTKs) composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. Met binds to the ligand, hepatocyte growth factor/scatter factor (HGF/SF), and is also called the HGF receptor. HGF/Met signaling plays a role in growth, transformation, cell motility, invasion, metastasis, angiogenesis, wound healing, and tissue regeneration. Aberrant expression of Met through mutations or gene amplification is associated with many human cancers including hereditary papillary renal and gastric carcinomas. The ligand for Ron is macrophage stimulating protein (MSP). Ron signaling is important in regulating cell motility, adhesion, proliferation, and apoptosis. Aberrant Ron expression is implicated in tumorigenesis and metastasis. The Met/Ron subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270649 [Multi-domain]  Cd Length: 262  Bit Score: 178.44  E-value: 3.61e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  802 DLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMrDSNYIS---KGSTFLPLKWMAPESIFNS 878
Cdd:cd05058    99 DLIGFGLQVAKGMEYLASKKFVHRDLAARNCMLDESFTVKVADFGLARDIY-DKEYYSvhnHTGAKLPVKWMALESLQTQ 177
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  879 LYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDqFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05058   178 KFTTKSDVWSFGVLLWELMTRGAPPYPDVDSFD-ITVYLLQGRRLLQPEYCPDPLYEVMLSCWHPKPEMRPTFSE 251
PTK_CCK4 cd05046
Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; CCK4, also ...
595-953 3.86e-50

Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; CCK4, also called protein tyrosine kinase 7 (PTK7), is an orphan receptor PTK (RTK) containing an extracellular region with seven immunoglobulin domains, a transmembrane segment, and an intracellular inactive pseudokinase domain, which shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. Studies in mice reveal that CCK4 is essential for neural development. Mouse embryos containing a truncated CCK4 die perinatally and display craniorachischisis, a severe form of neural tube defect. The mechanism of action of the CCK4 pseudokinase is still unknown. Other pseudokinases such as HER3 rely on the activity of partner RTKs. The CCK4 subfamily is part of a larger superfamily that includes other pseudokinases and the catalytic domains of active kinases including PTKs, protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133178 [Multi-domain]  Cd Length: 275  Bit Score: 178.81  E-value: 3.86e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  595 LPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKG 674
Cdd:cd05046     2 FPRSNLQEITTLGRGEFGEVFLAKAKGIEEEGGETLVLVKALQKTKDENLQSEFRRELDMFRKLS-HKNVVRLLGLCREA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  675 GPIYIITEYCRYGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmSKDESidyvpm 754
Cdd:cd05046    81 EPHYMILEYTDLGDLKQFLRATK----------------------------------------------SKDEK------ 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  755 ldmkgdikyadiespsymapydnyvpsapertyratliNDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLI 834
Cdd:cd05046   109 --------------------------------------LKPPPLSTKQKVALCTQIALGMDHLSNARFVHRDLAARNCLV 150
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  835 CEGKLVKICDFGLARDIMRDSNYISKgSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFY 914
Cdd:cd05046   151 SSQREVKVSLLSLSKDVYNSEYYKLR-NALIPLRWLAPEAVQEDDFSTKSDVWSFGVLMWEVFTQGELPFYGLS-DEEVL 228
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 226342982  915 NAIKRG-YRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05046   229 NRLQAGkLELPVPEGCPSRLYKLMTRCWAVNPKDRPSFSE 268
PTKc_Syk_like cd05060
Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
604-953 4.46e-50

Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Syk-like subfamily is composed of Syk, ZAP-70, Shark, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. They are involved in the signaling downstream of activated receptors (including B-cell, T-cell, and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. Syk is important in B-cell receptor signaling, while Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor signaling. Syk also plays a central role in Fc receptor-mediated phagocytosis in the adaptive immune system. Shark is exclusively expressed in ectodermally derived epithelia, and is localized preferentially to the apical surface of the epithelial cells, it may play a role in a signaling pathway for epithelial cell polarity. The Syk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270650 [Multi-domain]  Cd Length: 257  Bit Score: 177.93  E-value: 4.46e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEATAhgLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACtKGGPIYIITEY 683
Cdd:cd05060     1 KELGHGNFGSVRKGVY--LMKSGKEVEVAVKTLKQEHEKAGKKEFLREASVMAQLD-HPCIVRLIGVC-KGEPLMLVMEL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  684 CRYGDLVDYLHRNKHTflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgdiky 763
Cdd:cd05060    77 APLGPLLKYLKKRREI---------------------------------------------------------------- 92
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  764 adiespsymapydnyvpsapertyratlindsPVLsytDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKIC 843
Cdd:cd05060    93 --------------------------------PVS---DLKELAHQVAMGMAYLESKHFVHRDLAARNVLLVNRHQAKIS 137
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  844 DFGLARDIMRDSNYI-SKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKRGYR 922
Cdd:cd05060   138 DFGMSRALGAGSDYYrATTAGRWPLKWYAPECINYGKFSSKSDVWSYGVTLWEAFSYGAKPYGEMK-GPEVIAMLESGER 216
                         330       340       350
                  ....*....|....*....|....*....|.
gi 226342982  923 MAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05060   217 LPRPEECPQEIYSIMLSCWKYRPEDRPTFSE 247
PTKc_InsR cd05061
Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor; PTKs catalyze the transfer ...
593-951 1.83e-49

Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. InsR is a receptor PTK (RTK) that is composed of two alphabeta heterodimers. Binding of the insulin ligand to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, stimulating downstream kinase activities, which initiate signaling cascades and biological function. InsR signaling plays an important role in many cellular processes including glucose homeostasis, glycogen synthesis, lipid and protein metabolism, ion and amino acid transport, cell cycle and proliferation, cell differentiation, gene transcription, and nitric oxide synthesis. Insulin resistance, caused by abnormalities in InsR signaling, has been described in diabetes, hypertension, cardiovascular disease, metabolic syndrome, heart failure, and female infertility. The InsR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133192 [Multi-domain]  Cd Length: 288  Bit Score: 177.47  E-value: 1.83e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHlNVVNLLGACT 672
Cdd:cd05061     1 WEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLLGVVS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGGPIYIITEYCRYGDLVDYLHrnkhtflqrhsnkhcppsaelysnalpvgfSLPShlnltgesdggymdmskdesidyv 752
Cdd:cd05061    80 KGQPTLVVMELMAHGDLKSYLR------------------------------SLRP------------------------ 105
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyaDIESPsymapydnyvPSAPERTYRatlindspvlsytDLVGFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05061   106 ------------EAENN----------PGRPPPTLQ-------------EMIQMAAEIADGMAYLNAKKFVHRDLAARNC 150
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQ 912
Cdd:cd05061   151 MVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLS-NEQ 229
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05061   230 VLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTF 268
PTKc_FAK cd05056
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the ...
593-953 2.17e-49

Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. FAK is a cytoplasmic (or nonreceptor) PTK that contains an autophosphorylation site and a FERM domain at the N-terminus, a central tyr kinase domain, proline-rich regions, and a C-terminal FAT (focal adhesion targeting) domain. FAK activity is dependent on integrin-mediated cell adhesion, which facilitates N-terminal autophosphorylation. Full activation is achieved by the phosphorylation of its two adjacent A-loop tyrosines. FAK is important in mediating signaling initiated at sites of cell adhesions and at growth factor receptors. Through diverse molecular interactions, FAK functions as a biosensor or integrator to control cell motility. It is a key regulator of cell survival, proliferation, migration and invasion, and thus plays an important role in the development and progression of cancer. Src binds to autophosphorylated FAK forming the FAK-Src dual kinase complex, which is activated in a wide variety of tumor cells and generates signals promoting growth and metastasis. FAK is being developed as a target for cancer therapy. The FAK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133187 [Multi-domain]  Cd Length: 270  Bit Score: 176.46  E-value: 2.17e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHglSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACT 672
Cdd:cd05056     1 YEIQREDITLGRCIGEGQFGDVYQGVYM--SPENEKIAVAVKTCKNCTSPSVREKFLQEAYIMRQFD-HPHIVKLIGVIT 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGgPIYIITEYCRYGDLVDYLHRNKhtflqrhsnkhcppsaelysNALPVGfslpshlnltgesdggymdmskdesidyv 752
Cdd:cd05056    78 EN-PVWIVMELAPLGELRSYLQVNK--------------------YSLDLA----------------------------- 107
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyadiespsymapydnyvpsapertyratlindspvlsytDLVGFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05056   108 -------------------------------------------------SLILYAYQLSTALAYLESKRFVHRDIAARNV 138
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARdIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDq 912
Cdd:cd05056   139 LVSSPDCVKLGDFGLSR-YMEDESYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMLGVKPFQGVKNND- 216
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05056   217 VIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSKRPRFTE 257
PTKc_DDR_like cd05097
Catalytic domain of Discoidin Domain Receptor-like Protein Tyrosine Kinases; PTKs catalyze the ...
594-951 2.84e-49

Catalytic domain of Discoidin Domain Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR-like proteins are members of the DDR subfamily, which are receptor PTKs (RTKs) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDRs results in a slow but sustained receptor activation. DDRs regulate cell adhesion, proliferation, and extracellular matrix remodeling. They have been linked to a variety of human cancers including breast, colon, ovarian, brain, and lung. There is no evidence showing that DDRs act as transforming oncogenes. They are more likely to play a role in the regulation of tumor growth and metastasis. The DDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133228 [Multi-domain]  Cd Length: 295  Bit Score: 177.09  E-value: 2.84e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  594 ELPRDQLVLGRTLGSGAFGQVVEATAHGLSH---------SQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNV 664
Cdd:cd05097     1 EFPRQQLRLKEKLGEGQFGEVHLCEAEGLAEflgegapefDGQPVLVAVKMLRADVTKTARNDFLKEIKIMSRLK-NPNI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  665 VNLLGACTKGGPIYIITEYCRYGDLVDYLHrnkhtflQRhsnkhcppsaELYSnalpvgfslpshlnltgesdggymdms 744
Cdd:cd05097    80 IRLLGVCVSDDPLCMITEYMENGDLNQFLS-------QR----------EIES--------------------------- 115
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  745 kdesidyvpmldmkgdikyadiespsymapydnyvpsapertyRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVH 824
Cdd:cd05097   116 -------------------------------------------TFTHANNIPSVSIANLLYMAVQIASGMKYLASLNFVH 152
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  825 RDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTL-GGTP 903
Cdd:cd05097   153 RDLATRNCLVGNHYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEMFTLcKEQP 232
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 226342982  904 YPELP------MNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05097   233 YSLLSdeqvieNTGEFFRNQGRQIYLSQTPLCPSPVFKLMMRCWSRDIKDRPTF 286
PTKc_Fes cd05084
Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the ...
603-952 5.48e-49

Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes (or Fps) is a cytoplasmic (or nonreceptor) PTK containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated PTK activity. Fes kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells. It plays important roles in cell growth and differentiation, angiogenesis, inflammation and immunity, and cytoskeletal regulation. A recent study implicates Fes kinase as a tumor suppressor in colorectal cancer. The Fes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270667 [Multi-domain]  Cd Length: 252  Bit Score: 174.73  E-value: 5.48e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  603 GRTLGSGAFGQVVEatahGLSHSQATMkVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITE 682
Cdd:cd05084     1 GERIGRGNFGEVFS----GRLRADNTP-VAVKSCRETLPPDLKAKFLQEARILKQYS-HPNIVRLIGVCTQKQPIYIVME 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  683 YCRYGDLVdylhrnkhTFLQrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgdik 762
Cdd:cd05084    75 LVQGGDFL--------TFLR------------------------------------------------------------ 86
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  763 yadiespsymapydnyvpsapertyratliNDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKI 842
Cdd:cd05084    87 ------------------------------TEGPRLKVKELIRMVENAAAGMEYLESKHCIHRDLAARNCLVTEKNVLKI 136
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  843 CDFGLARDiMRDSNYISKGSTF-LPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPeLPMNDQFYNAIKRGY 921
Cdd:cd05084   137 SDFGMSRE-EEDGVYAATGGMKqIPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGAVPYA-NLSNQQTREAVEQGV 214
                         330       340       350
                  ....*....|....*....|....*....|.
gi 226342982  922 RMAQPAHASDEIYEIMQKCWEEKFETRPPFS 952
Cdd:cd05084   215 RLPCPENCPDEVYRLMEQCWEYDPRKRPSFS 245
PTKc_Jak_rpt2 cd05038
Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily ...
596-952 2.91e-48

Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily is composed of Jak1, Jak2, Jak3, TYK2, and similar proteins. They are PTKs, catalyzing the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jaks are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Most Jaks are expressed in a wide variety of tissues, except for Jak3, which is expressed only in hematopoietic cells. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). Jaks are also involved in regulating the surface expression of some cytokine receptors. The Jak-STAT pathway is involved in many biological processes including hematopoiesis, immunoregulation, host defense, fertility, lactation, growth, and embryogenesis. The Jak subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270634 [Multi-domain]  Cd Length: 284  Bit Score: 173.72  E-value: 2.91e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  596 PRDQLVLGRTLGSGAFGQVvEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGG 675
Cdd:cd05038     2 EERHLKFIKQLGEGHFGSV-ELCRYDPLGDNTGEQVAVKSLQPSGEEQHMSDFKREIEILRTLD-HEYIVKYKGVCESPG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  676 P--IYIITEYCRYGDLVDYLHRNKHTflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvp 753
Cdd:cd05038    80 RrsLRLIMEYLPSGSLRDYLQRHRDQ------------------------------------------------------ 105
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  754 mldmkgdikyadiespsymapydnyvpsapertyratliNDSPvlsytDLVGFSYQVANGMDFLASKNCVHRDLAARNVL 833
Cdd:cd05038   106 ---------------------------------------IDLK-----RLLLFASQICKGMEYLGSQRYIHRDLAARNIL 141
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  834 ICEGKLVKICDFGLARDIMRDSN-YISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPY--PELPMN 910
Cdd:cd05038   142 VESEDLVKISDFGLAKVLPEDKEyYYVKEPGESPIFWYAPECLRESRFSSASDVWSFGVTLYELFTYGDPSQspPALFLR 221
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 226342982  911 D-----------QFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFS 952
Cdd:cd05038   222 MigiaqgqmivtRLLELLKSGERLPRPPSCPDEVYDLMKECWEYEPQDRPSFS 274
PTKc_Axl cd05075
Catalytic domain of the Protein Tyrosine Kinase, Axl; PTKs catalyze the transfer of the ...
599-952 7.79e-48

Catalytic domain of the Protein Tyrosine Kinase, Axl; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Axl is widely expressed in a variety of organs and cells including epithelial, mesenchymal, hematopoietic, as well as non-transformed cells. It is important in many cellular functions such as survival, anti-apoptosis, proliferation, migration, and adhesion. Axl was originally isolated from patients with chronic myelogenous leukemia and a chronic myeloproliferative disorder. It is overexpressed in many human cancers including colon, squamous cell, thyroid, breast, and lung carcinomas. Axl is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to its ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Axl subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270660 [Multi-domain]  Cd Length: 277  Bit Score: 172.11  E-value: 7.79e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  599 QLVLGRTLGSGAFGQVVEATahgLSHSQATMKVAVKMLK-STARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKG--- 674
Cdd:cd05075     1 KLALGKTLGEGEFGSVMEGQ---LNQDDSVLKVAVKTMKiAICTRSEMEDFLSEAVCMKEFD-HPNVMRLIGVCLQNtes 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  675 ----GPIyIITEYCRYGDLvdylhrnkHTFLqrhsnkhcppsaeLYSNAlpvgfslpshlnltgesdggymdmskdesid 750
Cdd:cd05075    77 egypSPV-VILPFMKHGDL--------HSFL-------------LYSRL------------------------------- 103
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  751 yvpmldmkGDikyadieSPSYMapydnyvpsaPERTyratlindspvlsytdLVGFSYQVANGMDFLASKNCVHRDLAAR 830
Cdd:cd05075   104 --------GD-------CPVYL----------PTQM----------------LVKFMTDIASGMEYLSSKNFIHRDLAAR 142
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  831 NVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmN 910
Cdd:cd05075   143 NCMLNENMNVCVADFGLSKKIYNGDYYRQGRISKMPVKWIAIESLADRVYTTKSDVWSFGVTMWEIATRGQTPYPGVE-N 221
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 226342982  911 DQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFS 952
Cdd:cd05075   222 SEIYDYLRQGNRLKQPPDCLDGLYELMSSCWLLNPKDRPSFE 263
PTKc_Csk cd05082
Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the ...
593-953 2.09e-47

Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Csk is expressed in a wide variety of tissues. As a negative regulator of Src, Csk plays a role in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Csk is a cytoplasmic (or nonreceptor) PTK containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases, Csk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. In addition, Csk also shows Src-independent functions. It is a critical component in G-protein signaling, and plays a role in cytoskeletal reorganization and cell migration. The Csk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133213 [Multi-domain]  Cd Length: 256  Bit Score: 170.16  E-value: 2.09e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGlshsqatMKVAVKMLKSTARSsekQALMSELKIMSHLgPHLNVVNLLGACT 672
Cdd:cd05082     1 WALNMKELKLLQTIGKGEFGDVMLGDYRG-------NKVAVKCIKNDATA---QAFLAEASVMTQL-RHSNLVQLLGVIV 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 K-GGPIYIITEYCRYGDLVDYLHrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmSKDESIdy 751
Cdd:cd05082    70 EeKGGLYIVTEYMAKGSLVDYLR-------------------------------------------------SRGRSV-- 98
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  752 vpmldMKGDIkyadiespsymapydnyvpsapertyratlindspvlsytdLVGFSYQVANGMDFLASKNCVHRDLAARN 831
Cdd:cd05082    99 -----LGGDC-----------------------------------------LLKFSLDVCEAMEYLEGNNFVHRDLAARN 132
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  832 VLICEGKLVKICDFGLARDIMRdsnyiSKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMND 911
Cdd:cd05082   133 VLVSEDNVAKVSDFGLTKEASS-----TQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD 207
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 226342982  912 qFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05082   208 -VVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAAMRPSFLQ 248
PTKc_DDR2 cd05095
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2; PTKs catalyze ...
594-953 2.40e-47

Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR2 is a receptor PTK (RTK) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDR2 results in a slow but sustained receptor activation. DDR2 binds mostly to fibrillar collagens as well as collagen X. DDR2 is widely expressed in many tissues with the highest levels found in skeletal muscle, skin, kidney and lung. It is important in cell proliferation and development. Mice, with a deletion of DDR2, suffer from dwarfism and delayed healing of epidermal wounds. DDR2 also contributes to collagen (type I) regulation by inhibiting fibrillogenesis and altering the morphology of collagen fibers. It is also expressed in immature dendritic cells (DCs), where it plays a role in DC activation and function. The DDR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270677 [Multi-domain]  Cd Length: 297  Bit Score: 171.33  E-value: 2.40e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  594 ELPRDQLVLGRTLGSGAFGQVVEATAHGL------------SHSQATMkVAVKMLKSTARSSEKQALMSELKIMSHLgPH 661
Cdd:cd05095     1 EFPRKLLTFKEKLGEGQFGEVHLCEAEGMekfmdkdfalevSENQPVL-VAVKMLRADANKNARNDFLKEIKIMSRL-KD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  662 LNVVNLLGACTKGGPIYIITEYCRYGDLvdylhrnkHTFLQRHsnkhcppsaelysnalpvgfslpshlnltgESDGGym 741
Cdd:cd05095    79 PNIIRLLAVCITDDPLCMITEYMENGDL--------NQFLSRQ------------------------------QPEGQ-- 118
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  742 dmskdesidyvpmldmkgdikyadiespsymapydnyvpsapertyrATLINDSPVLSYTDLVGFSYQVANGMDFLASKN 821
Cdd:cd05095   119 -----------------------------------------------LALPSNALTVSYSDLRFMAAQIASGMKYLSSLN 151
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  822 CVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTL-G 900
Cdd:cd05095   152 FVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETLTFcR 231
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 226342982  901 GTPYPELP------MNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05095   232 EQPYSQLSdeqvieNTGEFFRDQGRQTYLPQPALCPDSVYKLMLSCWRRDTKDRPSFQE 290
PTKc_Chk cd05083
Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the ...
593-951 3.78e-47

Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Chk is also referred to as megakaryocyte-associated tyrosine kinase (Matk). Chk inhibits Src kinases using a noncatalytic mechanism by simply binding to them. As a negative regulator of Src kinases, Chk may play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Chk is expressed in brain and hematopoietic cells. Like Csk, it is a cytoplasmic (or nonreceptor) tyr kinase containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases that are anchored to the plasma membrane, Chk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Studies in mice reveal that Chk is not functionally redundant with Csk and that it plays an important role as a regulator of immune responses. Chk also plays a role in neural differentiation in a manner independent of Src by enhancing Mapk activation via Ras-mediated signaling. The Chk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270666 [Multi-domain]  Cd Length: 254  Bit Score: 169.28  E-value: 3.78e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGlshsqatMKVAVKMLKSTARSsekQALMSELKIMSHLgPHLNVVNLLGACT 672
Cdd:cd05083     1 WLLNLQKLTLGEIIGEGEFGAVLQGEYMG-------QKVAVKNIKCDVTA---QAFLEETAVMTKL-QHKNLVRLLGVIL 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGGpIYIITEYCRYGDLVDYLhRNKHTFLqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyv 752
Cdd:cd05083    70 HNG-LYIVMELMSKGNLVNFL-RSRGRAL--------------------------------------------------- 96
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyadiespsymapydnyVPSApertyratlindspvlsytDLVGFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05083    97 --------------------------VPVI-------------------QLLQFSLDVAEGMEYLESKKLVHRDLAARNI 131
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARDIMRDSNyiskgSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNdQ 912
Cdd:cd05083   132 LVSEDGVAKISDFGLAKVGSMGVD-----NSRLPVKWTAPEALKNKKFSSKSDVWSYGVLLWEVFSYGRAPYPKMSVK-E 205
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05083   206 VKEAVEKGYRMEPPEGCPPDVYSIMTSCWEAEPGKRPSF 244
PTK_Ryk cd05043
Pseudokinase domain of Ryk (Receptor related to tyrosine kinase); Ryk is a receptor tyr kinase ...
792-953 4.35e-47

Pseudokinase domain of Ryk (Receptor related to tyrosine kinase); Ryk is a receptor tyr kinase (RTK) containing an extracellular region with two leucine-rich motifs, a transmembrane segment, and an intracellular inactive pseudokinase domain, which shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. The extracellular region of Ryk shows homology to the N-terminal domain of Wnt inhibitory factor-1 (WIF) and serves as the ligand (Wnt) binding domain of Ryk. Ryk is expressed in many different tissues both during development and in adults, suggesting a widespread function. It acts as a chemorepulsive axon guidance receptor of Wnt glycoproteins and is responsible for the establishment of axon tracts during the development of the central nervous system. In addition, studies in mice reveal that Ryk is essential in skeletal, craniofacial, and cardiac development. Thus, it appears Ryk is involved in signal transduction despite its lack of kinase activity. Ryk may function as an accessory protein that modulates the signals coming from catalytically active partner RTKs such as the Eph receptors. The Ryk subfamily is part of a larger superfamily that includes other pseudokinases and the catalytic domains of active kinases including PTKs, protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270639 [Multi-domain]  Cd Length: 279  Bit Score: 169.94  E-value: 4.35e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  792 INDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDsNYISKG-STFLPLKWM 870
Cdd:cd05043   107 ANNPQALSTQQLVHMALQIACGMSYLHRRGVIHKDIAARNCVIDDELQVKITDNALSRDLFPM-DYHCLGdNENRPIKWM 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  871 APESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELpmnDQF--YNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETR 948
Cdd:cd05043   186 SLESLVNKEYSSASDVWSFGVLLWELMTLGQTPYVEI---DPFemAAYLKDGYRLAQPINCPDELFAVMACCWALDPEER 262

                  ....*
gi 226342982  949 PPFSQ 953
Cdd:cd05043   263 PSFQQ 267
S_TKc smart00220
Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or ...
602-953 6.45e-47

Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or threonine-specific kinase subfamily.


Pssm-ID: 214567 [Multi-domain]  Cd Length: 254  Bit Score: 168.48  E-value: 6.45e-47
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    602 LGRTLGSGAFGQVVEATAHGLSHsqatmKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIIT 681
Cdd:smart00220    3 ILEKLGEGSFGKVYLARDKKTGK-----LVAIKVIKKKKIKKDRERILREIKILKKLK-HPNIVRLYDVFEDEDKLYLVM 76
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    682 EYCRYGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvGFSLPshlnltgesdggymdmskdesidyvpmldmkgDI 761
Cdd:smart00220   77 EYCEGGDLFDLLKKRG-------------------------RLSED--------------------------------EA 99
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    762 KYadiespsymapydnyvpsapertyratlindspvlsytdlvgFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVK 841
Cdd:smart00220  100 RF------------------------------------------YLRQILSALEYLHSKGIVHRDLKPENILLDEDGHVK 137
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    842 ICDFGLARDIMRDSNYISK-GSTFlplkWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRG 920
Cdd:smart00220  138 LADFGLARQLDPGEKLTTFvGTPE----YMAPEVLLGKGYGKAVDIWSLGVILYELLT-GKPPFPGDDQLLELFKKIGKP 212
                           330       340       350
                    ....*....|....*....|....*....|....*
gi 226342982    921 YRMAQPAHA--SDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:smart00220  213 KPPFPPPEWdiSPEAKDLIRKLLVKDPEKRLTAEE 247
PTKc_Hck cd05073
Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the ...
593-951 6.55e-47

Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Hck is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Hck is present in myeloid and lymphoid cells that play a role in the development of cancer. It may be important in the oncogenic signaling of the protein Tel-Abl, which induces a chronic myelogenous leukemia (CML)-like disease. Hck also acts as a negative regulator of G-CSF-induced proliferation of granulocytic precursors, suggesting a possible role in the development of acute myeloid leukemia (AML). In addition, Hck is essential in regulating the degranulation of polymorphonuclear leukocytes. Genetic polymorphisms affect the expression level of Hck, which affects PMN mediator release and influences the development of chronic obstructive pulmonary disease (COPD). Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Hck subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270658 [Multi-domain]  Cd Length: 265  Bit Score: 169.05  E-value: 6.55e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHglSHSqatmKVAVKMLKSTARSSEkqALMSELKIMSHLgPHLNVVNLLGACT 672
Cdd:cd05073     6 WEIPRESLKLEKKLGAGQFGEVWMATYN--KHT----KVAVKTMKPGSMSVE--AFLAEANVMKTL-QHDKLVKLHAVVT 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGgPIYIITEYCRYGDLVDYLhrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgESDGGymdmskdesidyv 752
Cdd:cd05073    77 KE-PIYIITEFMAKGSLLDFL-----------------------------------------KSDEG------------- 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyadiespsymapydNYVPsapertyratlindspvlsYTDLVGFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05073   102 ------------------------SKQP-------------------LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANI 138
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARdIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQ 912
Cdd:cd05073   139 LVSASLVCKIADFGLAR-VIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMS-NPE 216
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05073   217 VIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTF 255
PTKc_TAM cd05035
Catalytic Domain of TAM (Tyro3, Axl, Mer) Protein Tyrosine Kinases; PTKs catalyze the transfer ...
600-952 1.51e-46

Catalytic Domain of TAM (Tyro3, Axl, Mer) Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The TAM subfamily consists of Tyro3 (or Sky), Axl, Mer (or Mertk), and similar proteins. TAM subfamily members are receptor tyr kinases (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. TAM proteins are implicated in a variety of cellular effects including survival, proliferation, migration, and phagocytosis. They are also associated with several types of cancer as well as inflammatory, autoimmune, vascular, and kidney diseases. The TAM subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270631 [Multi-domain]  Cd Length: 273  Bit Score: 168.48  E-value: 1.51e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  600 LVLGRTLGSGAFGQVVEATAHGLSHSQatMKVAVKMLKST-ARSSEKQALMSELKIMSHLGpHLNVVNLLGAC----TKG 674
Cdd:cd05035     1 LKLGKILGEGEFGSVMEAQLKQDDGSQ--LKVAVKTMKVDiHTYSEIEEFLSEAACMKDFD-HPNVMRLIGVCftasDLN 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  675 GPI--YIITEYCRYGDLvdylhrnkHTFLqrhsnkhcppsaeLYSNALPVGFSLPSHLnltgesdggymdmskdesidyv 752
Cdd:cd05035    78 KPPspMVILPFMKHGDL--------HSYL-------------LYSRLGGLPEKLPLQT---------------------- 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyadiespsymapydnyvpsapertyratlindspvlsytdLVGFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05035   115 --------------------------------------------------LLKFMVDIAKGMEYLSNRNFIHRDLAARNC 144
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQ 912
Cdd:cd05035   145 MLDENMTVCVADFGLSRKIYSGDYYRQGRISKMPVKWIALESLADNVYTSKSDVWSFGVTMWEIATRGQTPYPGVE-NHE 223
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFS 952
Cdd:cd05035   224 IYDYLRNGNRLKQPEDCLDEVYFLMYFCWTVDPKDRPTFT 263
PTKc_Tyro3 cd05074
Catalytic domain of the Protein Tyrosine Kinase, Tyro3; PTKs catalyze the transfer of the ...
595-951 2.07e-46

Catalytic domain of the Protein Tyrosine Kinase, Tyro3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tyro3 (or Sky) is predominantly expressed in the central nervous system and the brain, and functions as a neurotrophic factor. It is also expressed in osteoclasts and has a role in bone resorption. Tyro3 is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Tyro3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270659 [Multi-domain]  Cd Length: 284  Bit Score: 168.17  E-value: 2.07e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  595 LPRDQLVLGRTLGSGAFGQVVEATAHglSHSQATMKVAVKMLKSTA-RSSEKQALMSELKIMSHLGpHLNVVNLLGAC-- 671
Cdd:cd05074     6 IQEQQFTLGRMLGKGEFGSVREAQLK--SEDGSFQKVAVKMLKADIfSSSDIEEFLREAACMKEFD-HPNVIKLIGVSlr 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  672 --TKGG-PI-YIITEYCRYGDLvdylhrnkHTFLQrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdMSKde 747
Cdd:cd05074    83 srAKGRlPIpMVILPFMKHGDL--------HTFLL----------------------------------------MSR-- 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  748 sidyvpmldmkgdikyadiespsymapydnyvpsapertyratlINDSPV-LSYTDLVGFSYQVANGMDFLASKNCVHRD 826
Cdd:cd05074   113 --------------------------------------------IGEEPFtLPLQTLVRFMIDIASGMEYLSSKNFIHRD 148
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  827 LAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPE 906
Cdd:cd05074   149 LAARNCMLNENMTVCVADFGLSKKIYSGDYYRQGCASKLPVKWLALESLADNVYTTHSDVWAFGVTMWEIMTRGQTPYAG 228
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 226342982  907 LPmNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05074   229 VE-NSEIYNYLIKGNRLKQPPDCLEDVYELMCQCWSPEPKCRPSF 272
PTKc_Itk cd05112
Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs ...
598-952 2.15e-46

Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Itk, also known as Tsk or Emt, is a member of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Itk contains the Tec homology (TH) domain containing one proline-rich region and a zinc-binding region. Itk is expressed in T-cells and mast cells, and is important in their development and differentiation. Of the three Tec kinases expressed in T-cells, Itk plays the predominant role in T-cell receptor (TCR) signaling. It is activated by phosphorylation upon TCR crosslinking and is involved in the pathway resulting in phospholipase C-gamma1 activation and actin polymerization. It also plays a role in the downstream signaling of the T-cell costimulatory receptor CD28, the T-cell surface receptor CD2, and the chemokine receptor CXCR4. In addition, Itk is crucial for the development of T-helper(Th)2 effector responses. The Itk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133243 [Multi-domain]  Cd Length: 256  Bit Score: 167.43  E-value: 2.15e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  598 DQLVLGRTLGSGAFGQVVeatahgLSHSQATMKVAVKMLKSTARSSEKqaLMSELKIMSHLGpHLNVVNLLGACTKGGPI 677
Cdd:cd05112     4 SELTFVQEIGSGQFGLVH------LGYWLNKDKVAIKTIREGAMSEED--FIEEAEVMMKLS-HPKLVQLYGVCLEQAPI 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  678 YIITEYCRYGDLVDYLHRNKHTFLQRhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldm 757
Cdd:cd05112    75 CLVFEFMEHGCLSDYLRTQRGLFSAE------------------------------------------------------ 100
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  758 kgdikyadiespsymapydnyvpsapertyratlindspvlsytDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEG 837
Cdd:cd05112   101 --------------------------------------------TLLGMCLDVCEGMAYLEEASVIHRDLAARNCLVGEN 136
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  838 KLVKICDFGLARDIMRDSNYISKGSTFlPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYpELPMNDQFYNAI 917
Cdd:cd05112   137 QVVKVSDFGMTRFVLDDQYTSSTGTKF-PVKWSSPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPY-ENRSNSEVVEDI 214
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 226342982  918 KRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFS 952
Cdd:cd05112   215 NAGFRLYKPRLASTHVYEIMNHCWKERPEDRPSFS 249
PTKc_DDR1 cd05096
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1; PTKs catalyze ...
594-953 2.43e-46

Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR1 is a receptor PTK (RTK) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDR1 results in a slow but sustained receptor activation. DDR1 binds to all collagens tested to date (types I-IV). It is widely expressed in many tissues. It is abundant in the brain and is also found in keratinocytes, colonic mucosa epithelium, lung epithelium, thyroid follicles, and the islets of Langerhans. During embryonic development, it is found in the developing neuroectoderm. DDR1 is a key regulator of cell morphogenesis, differentiation and proliferation. It is important in the development of the mammary gland, the vasculator and the kidney. DDR1 is also found in human leukocytes, where it facilitates cell adhesion, migration, maturation, and cytokine production. The DDR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133227 [Multi-domain]  Cd Length: 304  Bit Score: 168.96  E-value: 2.43e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  594 ELPRDQLVLGRTLGSGAFGQV----VEaTAHGLSHSQ--------ATMKVAVKMLKSTARSSEKQALMSELKIMSHLG-P 660
Cdd:cd05096     1 KFPRGHLLFKEKLGEGQFGEVhlceVV-NPQDLPTLQfpfnvrkgRPLLVAVKILRPDANKNARNDFLKEVKILSRLKdP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  661 HlnVVNLLGACTKGGPIYIITEYCRYGDLVDYLhrnkhtflqrhsnkhcppsaelysnalpvgfslPSHLNLTGESDGGy 740
Cdd:cd05096    80 N--IIRLLGVCVDEDPLCMITEYMENGDLNQFL---------------------------------SSHHLDDKEENGN- 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  741 mdmskdesidyvpmldmkgdikyadiespsymapyDNYVPSAPertyratlindSPVLSYTDLVGFSYQVANGMDFLASK 820
Cdd:cd05096   124 -----------------------------------DAVPPAHC-----------LPAISYSSLLHVALQIASGMKYLSSL 157
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  821 NCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTL- 899
Cdd:cd05096   158 NFVHRDLATRNCLVGENLTIKIADFGMSRNLYAGDYYRIQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEILMLc 237
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  900 GGTPYPELPMND------QFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05096   238 KEQPYGELTDEQvienagEFFRDQGRQVYLFRPPPCPQGLYELMLQCWSRDCRERPSFSD 297
PTKc_Btk_Bmx cd05113
Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow ...
595-953 2.79e-46

Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Btk and Bmx (also named Etk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Btk contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Btk is expressed in B-cells, and a variety of myeloid cells including mast cells, platelets, neutrophils, and dendrictic cells. It interacts with a variety of partners, from cytosolic proteins to nuclear transcription factors, suggesting a diversity of functions. Stimulation of a diverse array of cell surface receptors, including antigen engagement of the B-cell receptor, leads to PH-mediated membrane translocation of Btk and subsequent phosphorylation by Src kinase and activation. Btk plays an important role in the life cycle of B-cells including their development, differentiation, proliferation, survival, and apoptosis. Mutations in Btk cause the primary immunodeficiency disease, X-linked agammaglobulinaemia (XLA) in humans. Bmx is primarily expressed in bone marrow and the arterial endothelium, and plays an important role in ischemia-induced angiogenesis. It facilitates arterial growth, capillary formation, vessel maturation, and bone marrow-derived endothelial progenitor cell mobilization. The Btk/Bmx subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173657 [Multi-domain]  Cd Length: 256  Bit Score: 166.98  E-value: 2.79e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  595 LPRDQLVLGRTLGSGAFGQVveatahGLSHSQATMKVAVKMLKSTARSSEKqaLMSELKIMSHLGpHLNVVNLLGACTKG 674
Cdd:cd05113     1 IDPKDLTFLKELGTGQFGVV------KYGKWRGQYDVAIKMIKEGSMSEDE--FIEEAKVMMNLS-HEKLVQLYGVCTKQ 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  675 GPIYIITEYCRYGDLVDYLHRNKHTFLqrhsnkhcppsaelysnalpvgfslPSHLnltgesdggyMDMSKDesidyvpm 754
Cdd:cd05113    72 RPIFIITEYMANGCLLNYLREMRKRFQ-------------------------TQQL----------LEMCKD-------- 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  755 ldmkgdikyadiespsymapydnyvpsapertyratlindspvlsytdlvgfsyqVANGMDFLASKNCVHRDLAARNVLI 834
Cdd:cd05113   109 -------------------------------------------------------VCEAMEYLESKQFLHRDLAARNCLV 133
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  835 CEGKLVKICDFGLARDIMRDSNYISKGSTFlPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYpELPMNDQFY 914
Cdd:cd05113   134 NDQGVVKVSDFGLSRYVLDDEYTSSVGSKF-PVRWSPPEVLMYSKFSSKSDVWAFGVLMWEVYSLGKMPY-ERFTNSETV 211
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  915 NAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05113   212 EHVSQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKI 250
PTKc_EphR cd05033
Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
595-953 1.27e-45

Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EphRs comprise the largest subfamily of receptor PTKs (RTKs). They can be classified into two classes (EphA and EphB), according to their extracellular sequences, which largely correspond to binding preferences for either GPI-anchored ephrin-A ligands or transmembrane ephrin-B ligands. Vertebrates have ten EphA and six EphB receptors, which display promiscuous ligand interactions within each class. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. This allows ephrin/EphR dimers to form, leading to the activation of the intracellular tyr kinase domain. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). The main effect of ephrin/EphR interaction is cell-cell repulsion or adhesion. Ephrin/EphR signaling is important in neural development and plasticity, cell morphogenesis and proliferation, cell-fate determination, embryonic development, tissue patterning, and angiogenesis.The EphR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270629 [Multi-domain]  Cd Length: 266  Bit Score: 165.24  E-value: 1.27e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  595 LPRDQLVLGRTLGSGAFGQVVEAtaHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKG 674
Cdd:cd05033     1 IDASYVTIEKVIGGGEFGEVCSG--SLKLPGKKEIDVAIKTLKSGYSDKQRLDFLTEASIMGQFD-HPNVIRLEGVVTKS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  675 GPIYIITEYCRYGDLvdylhrnkHTFLQRHSNKhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpm 754
Cdd:cd05033    78 RPVMIVTEYMENGSL--------DKFLRENDGK----------------------------------------------- 102
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  755 ldmkgdikyadiespsymapydnyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLI 834
Cdd:cd05033   103 -------------------------------------------FTVTQLVGMLRGIASGMKYLSEMNYVHRDLAARNILV 139
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  835 CEGKLVKICDFGLARDI-MRDSNYISKGSTfLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQF 913
Cdd:cd05033   140 NSDLVCKVSDFGLSRRLeDSEATYTTKGGK-IPIRWTAPEAIAYRKFTSASDVWSFGIVMWEVMSYGERPYWDMS-NQDV 217
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 226342982  914 YNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05033   218 IKAVEDGYRLPPPMDCPSALYQLMLDCWQKDRNERPTFSQ 257
PTKc_TrkC cd05094
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C; PTKs catalyze ...
595-948 2.72e-44

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkC is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkC to its ligand, neurotrophin 3 (NT3), results in receptor oligomerization and activation of the catalytic domain. TrkC is broadly expressed in the nervous system and in some non-neural tissues including the developing heart. NT3/TrkC signaling plays an important role in the innervation of the cardiac conducting system and the development of smooth muscle cells. Mice deficient with NT3 and TrkC have multiple heart defects. NT3/TrkC signaling is also critical for the development and maintenance of enteric neurons that are important for the control of gut peristalsis. The TrkC subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270676 [Multi-domain]  Cd Length: 287  Bit Score: 162.49  E-value: 2.72e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  595 LPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQaLMSELKIMSHLgPHLNVVNLLGACTKG 674
Cdd:cd05094     2 IKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKTLKDPTLAARKD-FQREAELLTNL-QHDHIVKFYGVCGDG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  675 GPIYIITEYCRYGDLvdylhrNKhtFLQRHSnkhcpPSAELYSNALPvgfslpshlnltgesdggymdmskdesidyvpm 754
Cdd:cd05094    80 DPLIMVFEYMKHGDL------NK--FLRAHG-----PDAMILVDGQP--------------------------------- 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  755 LDMKGDikyadiespsymapydnyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLI 834
Cdd:cd05094   114 RQAKGE-------------------------------------LGLSQMLHIATQIASGMVYLASQHFVHRDLATRNCLV 156
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  835 CEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFY 914
Cdd:cd05094   157 GANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLS-NTEVI 235
                         330       340       350
                  ....*....|....*....|....*....|....
gi 226342982  915 NAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETR 948
Cdd:cd05094   236 ECITQGRVLERPRVCPKEVYDIMLGCWQREPQQR 269
PTKc_IGF-1R cd05062
Catalytic domain of the Protein Tyrosine Kinase, Insulin-like Growth Factor-1 Receptor; PTKs ...
593-951 3.28e-44

Catalytic domain of the Protein Tyrosine Kinase, Insulin-like Growth Factor-1 Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. IGF-1R is a receptor PTK (RTK) that is composed of two alphabeta heterodimers. Binding of the ligand (IGF-1 or IGF-2) to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, which stimulates downstream kinase activities and biological function. IGF-1R signaling is important in the differentiation, growth, and survival of normal cells. In cancer cells, where it is frequently overexpressed, IGF-1R is implicated in proliferation, the suppression of apoptosis, invasion, and metastasis. IGF-1R is being developed as a therapeutic target in cancer treatment. The IGF-1R subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133193 [Multi-domain]  Cd Length: 277  Bit Score: 161.74  E-value: 3.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHlNVVNLLGACT 672
Cdd:cd05062     1 WEVAREKITMSRELGQGSFGMVYEGIAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGGPIYIITEYCRYGDLVDYLhRNKHTFLQRHSNKHCPPSAElysnalpvgfslpshlnltgesdggymdmskdesidyv 752
Cdd:cd05062    80 QGQPTLVIMELMTRGDLKSYL-RSLRPEMENNPVQAPPSLKK-------------------------------------- 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pMLDMKGDIkyadiespsymapydnyvpsapertyratlindspvlsytdlvgfsyqvANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05062   121 -MIQMAGEI-------------------------------------------------ADGMAYLNANKFVHRDLAARNC 150
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQ 912
Cdd:cd05062   151 MVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGMS-NEQ 229
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05062   230 VLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF 268
PTKc_Mer cd14204
Catalytic Domain of the Protein Tyrosine Kinase, Mer; PTKs catalyze the transfer of the ...
597-953 2.69e-43

Catalytic Domain of the Protein Tyrosine Kinase, Mer; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Mer (or Mertk) is named after its original reported expression pattern (monocytes, epithelial, and reproductive tissues). It is required for the ingestion of apoptotic cells by phagocytes such as macrophages, retinal pigment epithelial cells, and dendritic cells. Mer is also important in maintaining immune homeostasis. Mer is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Mer subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271106 [Multi-domain]  Cd Length: 284  Bit Score: 159.33  E-value: 2.69e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  597 RDQLVLGRTLGSGAFGQVVEATahgLSHSQAT-MKVAVKMLKSTARSS-EKQALMSELKIMSHLGpHLNVVNLLGACTKG 674
Cdd:cd14204     6 RNLLSLGKVLGEGEFGSVMEGE---LQQPDGTnHKVAVKTMKLDNFSQrEIEEFLSEAACMKDFN-HPNVIRLLGVCLEV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  675 GPIYI-----ITEYCRYGDLVDYLHRNKHtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskDESI 749
Cdd:cd14204    82 GSQRIpkpmvILPFMKYGDLHSFLLRSRL-----------------------------------------------GSGP 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  750 DYVPMldmkgdikyadiespsymapydnyvpsapertyratlindspvlsyTDLVGFSYQVANGMDFLASKNCVHRDLAA 829
Cdd:cd14204   115 QHVPL----------------------------------------------QTLLKFMIDIALGMEYLSSRNFLHRDLAA 148
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  830 RNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELpM 909
Cdd:cd14204   149 RNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAVESLADRVYTVKSDVWAFGVTMWEIATRGMTPYPGV-Q 227
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 226342982  910 NDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14204   228 NHEIYDYLLHGHRLKQPEDCLDELYDIMYSCWRSDPTDRPTFTQ 271
PTKc_TrkB cd05093
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; PTKs catalyze ...
595-948 7.85e-43

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkB is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkB to its ligands, brain-derived neurotrophic factor (BDNF) or neurotrophin 4 (NT4), results in receptor oligomerization and activation of the catalytic domain. TrkB is broadly expressed in the nervous system and in some non-neural tissues. It plays important roles in cell proliferation, differentiation, and survival. BDNF/Trk signaling plays a key role in regulating activity-dependent synaptic plasticity. TrkB also contributes to protection against gp120-induced neuronal cell death. TrkB overexpression is associated with poor prognosis in neuroblastoma (NB) and other human cancers. It acts as a suppressor of anoikis (detachment-induced apoptosis) and contributes to tumor metastasis. The TrkB subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270675 [Multi-domain]  Cd Length: 288  Bit Score: 158.28  E-value: 7.85e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  595 LPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQaLMSELKIMSHLgPHLNVVNLLGACTKG 674
Cdd:cd05093     2 IKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD-FHREAELLTNL-QHEHIVKFYGVCVEG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  675 GPIYIITEYCRYGDLvdylhrNKhtFLQRHSnkhcpPSAELYSNALPvgfslpshlnltgesdggymdmskdesidyvpm 754
Cdd:cd05093    80 DPLIMVFEYMKHGDL------NK--FLRAHG-----PDAVLMAEGNR--------------------------------- 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  755 ldmkgdikyadiespsymapydnyvpsapertyratlindsPV-LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVL 833
Cdd:cd05093   114 -----------------------------------------PAeLTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCL 152
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  834 ICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQF 913
Cdd:cd05093   153 VGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLS-NNEV 231
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 226342982  914 YNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETR 948
Cdd:cd05093   232 IECITQGRVLQRPRTCPKEVYDLMLGCWQREPHMR 266
PTKc_Tec_Rlk cd05114
Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular ...
599-953 1.44e-42

Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tec and Rlk (also named Txk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. Instead of PH, Rlk contains an N-terminal cysteine-rich region. In addition to PH, Tec also contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Tec kinases are expressed mainly by haematopoietic cells. Tec is more widely-expressed than other Tec-like subfamily kinases. It is found in endothelial cells, both B- and T-cells, and a variety of myeloid cells including mast cells, erythroid cells, platelets, macrophages and neutrophils. Rlk is expressed in T-cells and mast cell lines. Tec and Rlk are both key components of T-cell receptor (TCR) signaling. They are important in TCR-stimulated proliferation, IL-2 production and phopholipase C-gamma1 activation. The Tec/Rlk subfamily is part of a larger superfamily, that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270685 [Multi-domain]  Cd Length: 260  Bit Score: 156.56  E-value: 1.44e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  599 QLVLGRTLGSGAFGQVveatahGLSHSQATMKVAVKMLKSTARSSEKqaLMSELKIMSHLGpHLNVVNLLGACTKGGPIY 678
Cdd:cd05114     5 ELTFMKELGSGLFGVV------RLGKWRAQYKVAIKAIREGAMSEED--FIEEAKVMMKLT-HPKLVQLYGVCTQQKPIY 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  679 IITEYCRYGDLVDYLHRNKHTFlqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmSKDEsidyvpmldmk 758
Cdd:cd05114    76 IVTEFMENGCLLNYLRQRRGKL-------------------------------------------SRDM----------- 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  759 gdikyadiespsymapydnyvpsapertyratlindspvlsytdLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGK 838
Cdd:cd05114   102 --------------------------------------------LLSMCQDVCEGMEYLERNNFIHRDLAARNCLVNDTG 137
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  839 LVKICDFGLARDIMRDSNYISKGSTFlPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYpELPMNDQFYNAIK 918
Cdd:cd05114   138 VVKVSDFGMTRYVLDDQYTSSSGAKF-PVKWSPPEVFNYSKFSSKSDVWSFGVLMWEVFTEGKMPF-ESKSNYEVVEMVS 215
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 226342982  919 RGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05114   216 RGHRLYRPKLASKSVYEVMYSCWHEKPEGRPTFAD 250
PTKc_Ack_like cd05040
Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs ...
782-953 4.12e-42

Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes Ack1, thirty-eight-negative kinase 1 (Tnk1), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing an N-terminal catalytic domain, an SH3 domain, a Cdc42-binding CRIB domain, and a proline-rich region. They are mainly expressed in brain and skeletal tissues and are involved in the regulation of cell adhesion and growth, receptor degradation, and axonal guidance. Ack1 is also associated with androgen-independent prostate cancer progression. Tnk1 regulates TNFalpha signaling and may play an important role in cell death. The Ack-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270636 [Multi-domain]  Cd Length: 258  Bit Score: 154.81  E-value: 4.12e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  782 APERTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-MRDSNYISK 860
Cdd:cd05040    79 APLGSLLDRLRKDQGHFLISTLCDYAVQIANGMAYLESKRFIHRDLAARNILLASKDKVKIGDFGLMRALpQNEDHYVMQ 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  861 GSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKC 940
Cdd:cd05040   159 EHRKVPFAWCAPESLKTRKFSHASDVWMFGVTLWEMFTYGEEPWLGLNGSQILEKIDKEGERLERPDDCPQDIYNVMLQC 238
                         170
                  ....*....|...
gi 226342982  941 WEEKFETRPPFSQ 953
Cdd:cd05040   239 WAHKPADRPTFVA 251
Ig4_PDGFR cd05859
Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR); The ...
313-414 7.38e-42

Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR); The members here are composed of the fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR; also known as cluster of differentiation (CD) 140a) alpha and beta. PDGF is a potent mitogen for connective tissue cells. PDGF-stimulated processes are mediated by three different PDGFs (PDGF-A,PDGF-B, and PDGF-C). PDGFR alpha binds to all three PDGFs, whereas the PDGFR beta binds only to PDGF-B. PDGF alpha is organized as an extracellular component having five Ig-like domains, a transmembrane segment, and a cytoplasmic portion having protein tyrosine kinase activity. In mice, PDGFR alpha and PDGFR beta are essential for normal development.


Pssm-ID: 409445  Cd Length: 101  Bit Score: 148.47  E-value: 7.38e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  313 GYVRLLETLGDVEIAELHRSRTLRVVFEAYPMPSVLWLKDNRTLGDSgAGELVLSTRNMSETRYVSELILVRVKVSEAGY 392
Cdd:cd05859     1 GFIALKPTFGQLEFANLHEVKEFVVEVEAYPPPQIRWLKDNRTLIEN-LTEITTSTRNVQETRYVSKLKLIRAKEEDSGL 79
                          90       100
                  ....*....|....*....|..
gi 226342982  393 YTMRAFHEDDEVQLSFKLQVNV 414
Cdd:cd05859    80 YTALAQNEDAVKSYTFALQIQV 101
PTKc_Yes cd05069
Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the ...
593-951 1.47e-41

Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Yes (or c-Yes) is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. c-Yes kinase is the cellular homolog of the oncogenic protein (v-Yes) encoded by the Yamaguchi 73 and Esh sarcoma viruses. It displays functional overlap with other Src subfamily members, particularly Src. It also shows some unique functions such as binding to occludins, transmembrane proteins that regulate extracellular interactions in tight junctions. Yes also associates with a number of proteins in different cell types that Src does not interact with, like JAK2 and gp130 in pre-adipocytes, and Pyk2 in treated pulmonary vein endothelial cells. Although the biological function of Yes remains unclear, it appears to have a role in regulating cell-cell interactions and vesicle trafficking in polarized cells. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Yes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270654 [Multi-domain]  Cd Length: 279  Bit Score: 154.07  E-value: 1.47e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGlshsqaTMKVAVKMLKSTARSSEkqALMSELKIMSHLgPHLNVVNLLGACT 672
Cdd:cd05069     7 WEIPRESLRLDVKLGQGCFGEVWMGTWNG------TTKVAIKTLKPGTMMPE--AFLQEAQIMKKL-RHDKLVPLYAVVS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGgPIYIITEYCRYGDLVDYLHrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgESDGGYMDMSKdesidyv 752
Cdd:cd05069    78 EE-PIYIVTEFMGKGSLLDFLK----------------------------------------EGDGKYLKLPQ------- 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyadiespsymapydnyvpsapertyratlindspvlsytdLVGFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05069   110 --------------------------------------------------LVDMAAQIADGMAYIERMNYIHRDLRAANI 139
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARdIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELpMNDQ 912
Cdd:cd05069   140 LVGDNLVCKIADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM-VNRE 217
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05069   218 VLEQVERGYRMPCPQGCPESLHELMKLCWKKDPDERPTF 256
PTKc_Src_Fyn_like cd14203
Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
604-951 2.53e-41

Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes a subset of Src-like PTKs including Src, Fyn, Yrk, and Yes, which are all widely expressed. Yrk has been detected only in chickens. It is primarily found in neuronal and epithelial cells and in macrophages. It may play a role in inflammation and in response to injury. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. They are also implicated in acute inflammatory responses and osteoclast function. The Src/Fyn-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271105 [Multi-domain]  Cd Length: 248  Bit Score: 152.38  E-value: 2.53e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEATAHGlshsqaTMKVAVKMLKSTARSSEkqALMSELKIMSHLgPHLNVVNLLgACTKGGPIYIITEY 683
Cdd:cd14203     1 VKLGQGCFGEVWMGTWNG------TTKVAIKTLKPGTMSPE--AFLEEAQIMKKL-RHDKLVQLY-AVVSEEPIYIVTEF 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  684 CRYGDLVDYLHrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgESDGGYMDMSKdesidyvpmldmkgdiky 763
Cdd:cd14203    71 MSKGSLLDFLK----------------------------------------DGEGKYLKLPQ------------------ 92
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  764 adiespsymapydnyvpsapertyratlindspvlsytdLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKIC 843
Cdd:cd14203    93 ---------------------------------------LVDMAAQIASGMAYIERMNYIHRDLRAANILVGDNLVCKIA 133
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  844 DFGLARdIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELpMNDQFYNAIKRGYRM 923
Cdd:cd14203   134 DFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM-NNREVLEQVERGYRM 211
                         330       340
                  ....*....|....*....|....*...
gi 226342982  924 AQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd14203   212 PCPPGCPESLHELMCQCWRKDPEERPTF 239
IgI_PDGFR-alphabeta cd05861
Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha ...
211-309 1.11e-40

Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha and beta; member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (also known as cluster of differentiation (CD) 140a), and beta (also known as CD140b). PDGF is a potent mitogen for connective tissue cells. PDGF-stimulated processes are mediated by three different PDGFs (PDGF-A,PDGF-B, and PDGF-C). PDGFRalpha binds to all three PDGFs, whereas the PDGFRbeta binds only to PDGF-B. PDGFRs alpha and beta have similar organization: an extracellular component with five Ig-like domains, a transmembrane segment, and a cytoplasmic portion having protein tyrosine kinase activity. In mice, PDGFRalpha and PDGFRbeta are essential for normal development.


Pssm-ID: 409447  Cd Length: 99  Bit Score: 145.05  E-value: 1.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  211 SSINVSVNAVQTVVRQGESITIRCIVMGNDVVNFQWTYPRMKSGRLVEPVTDYLfgVPS-RIGSILHIPTAELSDSGTYT 289
Cdd:cd05861     1 SSINVEMEAVKTVVRQGETITLMCIVIGNEVVDLEWTYPGKESGRGIEPVEEFK--VPPyHLVYTLTIPSATLEDSGTYE 78
                          90       100
                  ....*....|....*....|
gi 226342982  290 CNVSVSVNDHGDEKAINISV 309
Cdd:cd05861    79 CAVTEATNDHQDEKKINITV 98
PTKc_Src cd05071
Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the ...
593-951 5.04e-40

Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src (or c-Src) is a cytoplasmic (or non-receptor) PTK, containing an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region with a conserved tyr. It is activated by autophosphorylation at the tyr kinase domain, and is negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). c-Src is the vertebrate homolog of the oncogenic protein (v-Src) from Rous sarcoma virus. Together with other Src subfamily proteins, it is involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. Src also play a role in regulating cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Elevated levels of Src kinase activity have been reported in a variety of human cancers. Several inhibitors of Src have been developed as anti-cancer drugs. Src is also implicated in acute inflammatory responses and osteoclast function. The Src subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270656 [Multi-domain]  Cd Length: 277  Bit Score: 149.84  E-value: 5.04e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGlshsqaTMKVAVKMLKSTARSSEkqALMSELKIMSHLgPHLNVVNLLGACT 672
Cdd:cd05071     4 WEIPRESLRLEVKLGQGCFGEVWMGTWNG------TTRVAIKTLKPGTMSPE--AFLQEAQVMKKL-RHEKLVQLYAVVS 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGgPIYIITEYCRYGDLVDYLHRNKHTFLQrhsnkhcppsaelysnalpvgfsLPShlnltgesdggymdmskdesidyv 752
Cdd:cd05071    75 EE-PIYIVTEYMSKGSLLDFLKGEMGKYLR-----------------------LPQ------------------------ 106
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyadiespsymapydnyvpsapertyratlindspvlsytdLVGFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05071   107 --------------------------------------------------LVDMAAQIASGMAYVERMNYVHRDLRAANI 136
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARdIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELpMNDQ 912
Cdd:cd05071   137 LVGENLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNRE 214
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05071   215 VLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTF 253
PTKc_Ror2 cd05091
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor ...
606-951 1.11e-39

Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror2 plays important roles in skeletal and heart formation. Ror2-deficient mice show widespread bone abnormalities, ventricular defects in the heart, and respiratory dysfunction. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Ror2 is also implicated in neural development. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The Ror2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270673 [Multi-domain]  Cd Length: 284  Bit Score: 149.01  E-value: 1.11e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACTKGGPIYIITEYCR 685
Cdd:cd05091    14 LGEDRFGKVYKGHLFGTAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRSRL-QHPNIVCLLGVVTKEQPMSMIFSYCS 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  686 YGDLvdylhrnkHTFLQRHSnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgdikyad 765
Cdd:cd05091    93 HGDL--------HEFLVMRS------------------------------------------------------------ 104
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  766 iespsymaPYDNYVPSAPERTYRATLindspvlSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDF 845
Cdd:cd05091   105 --------PHSDVGSTDDDKTVKSTL-------EPADFLHIVTQIAAGMEYLSSHHVVHKDLATRNVLVFDKLNVKISDL 169
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  846 GLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKRGYRMAQ 925
Cdd:cd05091   170 GLFREVYAADYYKLMGNSLLPIRWMSPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYS-NQDVIEMIRNRQVLPC 248
                         330       340
                  ....*....|....*....|....*.
gi 226342982  926 PAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05091   249 PDDCPAWVYTLMLECWNEFPSRRPRF 274
PKc cd00180
Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group ...
606-953 1.93e-39

Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. PKs make up a large family of serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and more than 500 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase.


Pssm-ID: 270622 [Multi-domain]  Cd Length: 215  Bit Score: 145.88  E-value: 1.93e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATahglsHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACTKGGPIYIITEYCR 685
Cdd:cd00180     1 LGKGSFGKVYKAR-----DKETGKKVAVKVIPKEKLKKLLEELLREIEILKKL-NHPNIVKLYDVFETENFLYLVMEYCE 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  686 YGDLVDYLHRNKHTFlqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgdikyad 765
Cdd:cd00180    75 GGSLKDLLKENKGPL----------------------------------------------------------------- 89
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  766 iespsymapydnyvpsaPERTyratlindspVLSYTdlvgfsYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDF 845
Cdd:cd00180    90 -----------------SEEE----------ALSIL------RQLLSALEYLHSNGIIHRDLKPENILLDSDGTVKLADF 136
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  846 GLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIftlggtpypelpmndqfynaikrgyrmaq 925
Cdd:cd00180   137 GLAKDLDSDDSLLKTTGGTTPPYYAPPELLGGRYYGPKVDIWSLGVILYEL----------------------------- 187
                         330       340
                  ....*....|....*....|....*...
gi 226342982  926 pahasDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd00180   188 -----EELKDLIRRMLQYDPKKRPSAKE 210
PTKc_Fyn cd05070
Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the ...
593-951 4.48e-39

Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fyn and Yrk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Fyn, together with Lck, plays a critical role in T-cell signal transduction by phosphorylating ITAM (immunoreceptor tyr activation motif) sequences on T-cell receptors, ultimately leading to the proliferation and differentiation of T-cells. In addition, Fyn is involved in the myelination of neurons, and is implicated in Alzheimer's and Parkinson's diseases. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Fyn/Yrk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase.


Pssm-ID: 270655 [Multi-domain]  Cd Length: 274  Bit Score: 146.75  E-value: 4.48e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGlshsqaTMKVAVKMLKSTARSSEkqALMSELKIMSHLgPHLNVVNLLGACT 672
Cdd:cd05070     4 WEIPRESLQLIKRLGNGQFGEVWMGTWNG------NTKVAIKTLKPGTMSPE--SFLEEAQIMKKL-KHDKLVQLYAVVS 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGgPIYIITEYCRYGDLVDYLhrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgeSDGgymdmskdesidyv 752
Cdd:cd05070    75 EE-PIYIVTEYMSKGSLLDFL------------------------------------------KDG-------------- 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyadiespsymapydnyvpsapertyratlinDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd05070    98 -----------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANI 136
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARdIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQ 912
Cdd:cd05070   137 LVGNGLICKIADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMN-NRE 214
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05070   215 VLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTF 253
PTKc_EphR_A2 cd05063
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the ...
604-951 1.12e-38

Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The EphA2 receptor is overexpressed in tumor cells and tumor blood vessels in a variety of cancers including breast, prostate, lung, and colon. As a result, it is an attractive target for drug design since its inhibition could affect several aspects of tumor progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 133194 [Multi-domain]  Cd Length: 268  Bit Score: 145.50  E-value: 1.12e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEATAHGLSHSQATmkVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITEY 683
Cdd:cd05063    11 KVIGAGEFGEVFRGILKMPGRKEVA--VAIKTLKPGYTEKQRQDFLSEASIMGQFS-HHNIIRLEGVVTKFKPAMIITEY 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  684 CRYGDLVDYLHrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgESDGGYmdmskdesidyvpmldmkgdiky 763
Cdd:cd05063    88 MENGALDKYLR----------------------------------------DHDGEF----------------------- 104
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  764 adiespsymapydnyvpsapertyratlindspvlSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKIC 843
Cdd:cd05063   105 -----------------------------------SSYQLVGMLRGIAAGMKYLSDMNYVHRDLAARNILVNSNLECKVS 149
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  844 DFGLARDIMRD--SNYISKGSTfLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKRGY 921
Cdd:cd05063   150 DFGLSRVLEDDpeGTYTTSGGK-IPIRWTAPEAIAYRKFTSASDVWSFGIVMWEVMSFGERPYWDMS-NHEVMKAINDGF 227
                         330       340       350
                  ....*....|....*....|....*....|
gi 226342982  922 RMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05063   228 RLPAPMDCPSAVYQLMLQCWQQDRARRPRF 257
PTKc_Ror1 cd05090
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor ...
594-951 3.07e-38

Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror kinases are expressed in many tissues during development. Avian Ror1 was found to be involved in late limb development. Studies in mice reveal that Ror1 is important in the regulation of neurite growth in central neurons, as well as in respiratory development. Loss of Ror1 also enhances the heart and skeletal abnormalities found in Ror2-deficient mice. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The Ror1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270672 [Multi-domain]  Cd Length: 283  Bit Score: 144.77  E-value: 3.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  594 ELPRDQLVLGRTLGSGAFGQVVEATAH--GLSHSQAtmkVAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGAC 671
Cdd:cd05090     1 ELPLSAVRFMEELGECAFGKIYKGHLYlpGMDHAQL---VAIKTLKDYNNPQQWNEFQQEASLMTEL-HHPNIVCLLGVV 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  672 TKGGPIYIITEYCRYGDLVDYLhrnkhTFLQRHSNKHCppsaelysnalpvgfslpshlnltgesdggymdmSKDEsidy 751
Cdd:cd05090    77 TQEQPVCMLFEFMNQGDLHEFL-----IMRSPHSDVGC----------------------------------SSDE---- 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  752 vpmldmkgdikyadiespsymapyDNYVPSApertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARN 831
Cdd:cd05090   114 ------------------------DGTVKSS---------------LDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARN 154
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  832 VLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmND 911
Cdd:cd05090   155 ILVGEQLHVKISDLGLSREIYSSDYYRVQNKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFS-NQ 233
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 226342982  912 QFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05090   234 EVIEMVRKRQLLPCSEDCPPRMYSLMTECWQEIPSRRPRF 273
PTKc_Zap-70 cd05115
Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa; PTKs ...
798-951 5.53e-38

Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Zap-70 is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor (TCR) signaling. Zap-70 binds the phosphorylated ITAM (immunoreceptor tyr activation motif) sequences of the activated TCR zeta-chain through its SH2 domains, leading to its phosphorylation and activation. It then phosphorylates target proteins, which propagate the signals to downstream pathways. Zap-70 is hardly detected in normal peripheral B-cells, but is present in some B-cell malignancies. It is used as a diagnostic marker for chronic lymphocytic leukemia (CLL) as it is associated with the more aggressive subtype of the disease. The Zap-70 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270686 [Multi-domain]  Cd Length: 269  Bit Score: 143.55  E-value: 5.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  798 LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYIsKGSTF--LPLKWMAPESI 875
Cdd:cd05115   101 ITVSNVVELMHQVSMGMKYLEEKNFVHRDLAARNVLLVNQHYAKISDFGLSKALGADDSYY-KARSAgkWPLKWYAPECI 179
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226342982  876 FNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05115   180 NFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMK-GPEVMSFIEQGKRMDCPAECPPEMYALMSDCWIYKWEDRPNF 254
PTKc_Syk cd05116
Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the ...
801-952 5.82e-38

Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Syk is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Syk was first cloned from the spleen, and its function in hematopoietic cells is well-established. It is involved in the signaling downstream of activated receptors (including B-cell and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. More recently, Syk expression has been detected in other cell types (including epithelial cells, vascular endothelial cells, neurons, hepatocytes, and melanocytes), suggesting a variety of biological functions in non-immune cells. Syk plays a critical role in maintaining vascular integrity and in wound healing during embryogenesis. It also regulates Vav3, which is important in osteoclast function including bone development. In breast epithelial cells, where Syk acts as a negative regulator for EGFR signaling, loss of Syk expression is associated with abnormal proliferation during cancer development suggesting a potential role as a tumor suppressor. In mice, Syk has been shown to inhibit malignant transformation of mammary epithelial cells induced with murine mammary tumor virus (MMTV). The Syk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133247 [Multi-domain]  Cd Length: 257  Bit Score: 143.18  E-value: 5.82e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  801 TDLVgfsYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYI-SKGSTFLPLKWMAPESIFNSL 879
Cdd:cd05116    98 TELV---HQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYkAQTHGKWPVKWYAPECMNYYK 174
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982  880 YTTLSDVWSFGILLWEIFTLGGTPYPELPMNDqFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFS 952
Cdd:cd05116   175 FSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNE-VTQMIEKGERMECPAGCPPEMYDLMKLCWTYDVDERPGFA 246
PTKc_EphR_A cd05066
Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; PTKs catalyze ...
604-953 1.93e-37

Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of most class EphA receptors including EphA3, EphA4, EphA5, and EphA7, but excluding EphA1, EphA2 and EphA10. Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. One exception is EphA4, which also binds ephrins-B2/B3. EphA receptors and ephrin-A ligands are expressed in multiple areas of the developing brain, especially in the retina and tectum. They are part of a system controlling retinotectal mapping. EphRs comprise the largest subfamily of receptor PTKs (RTKs). EphRs contain an ephrin-binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270651 [Multi-domain]  Cd Length: 267  Bit Score: 141.93  E-value: 1.93e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEATAHglSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITEY 683
Cdd:cd05066    10 KVIGAGEFGEVCSGRLK--LPGKREIPVAIKTLKAGYTEKQRRDFLSEASIMGQFD-HPNIIHLEGVVTRSKPVMIVTEY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  684 CRYGDLvdylhrnkHTFLQRHsnkhcppsaelysnalpvgfslpshlnltgesDGGYmdmskdesidyvpmldmkgdiky 763
Cdd:cd05066    87 MENGSL--------DAFLRKH--------------------------------DGQF----------------------- 103
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  764 adiespsymapydnyvpsapertyraTLINdspvlsytdLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKIC 843
Cdd:cd05066   104 --------------------------TVIQ---------LVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVS 148
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  844 DFGLARDIMRD--SNYISKGSTfLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKRGY 921
Cdd:cd05066   149 DFGLSRVLEDDpeAAYTTRGGK-IPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWEMS-NQDVIKAIEEGY 226
                         330       340       350
                  ....*....|....*....|....*....|..
gi 226342982  922 RMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05066   227 RLPAPMDCPAALHQLMLDCWQKDRNERPKFEQ 258
PTKc_EGFR cd05108
Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; PTKs ...
604-953 1.03e-36

Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER1, ErbB1) is a receptor PTK (RTK) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands for EGFR include EGF, heparin binding EGF-like growth factor (HBEGF), epiregulin, amphiregulin, TGFalpha, and betacellulin. Upon ligand binding, EGFR can form homo- or heterodimers with other EGFR subfamily members. The EGFR signaling pathway is one of the most important pathways regulating cell proliferation, differentiation, survival, and growth. Overexpression and mutation in the kinase domain of EGFR have been implicated in the development and progression of a variety of cancers. A number of monoclonal antibodies and small molecule inhibitors have been developed that target EGFR, including the antibodies Cetuximab and Panitumumab, which are used in combination with other therapies for the treatment of colorectal cancer and non-small cell lung carcinoma (NSCLC). The small molecule inhibitors Gefitinib (Iressa) and Erlotinib (Tarceva), already used for NSCLC, are undergoing clinical trials for other types of cancer including gastrointestinal, breast, head and neck, and bladder. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270683 [Multi-domain]  Cd Length: 313  Bit Score: 141.31  E-value: 1.03e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEatahGL---SHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHL-GPHlnVVNLLGACTKGGpIYI 679
Cdd:cd05108    13 KVLGSGAFGTVYK----GLwipEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVdNPH--VCRLLGICLTST-VQL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  680 ITEYCRYGDLVDYLHRNKHTFLQRHsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkg 759
Cdd:cd05108    86 ITQLMPFGCLLDYVREHKDNIGSQY------------------------------------------------------- 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  760 dikyadiespsymapydnyvpsapertyratlindspvlsytdLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKL 839
Cdd:cd05108   111 -------------------------------------------LLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH 147
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  840 VKICDFGLARDIMRDSN-YISKGSTfLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNdQFYNAIK 918
Cdd:cd05108   148 VKITDFGLAKLLGAEEKeYHAEGGK-VPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPAS-EISSILE 225
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 226342982  919 RGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05108   226 KGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRE 260
PTKc_HER2 cd05109
Catalytic domain of the Protein Tyrosine Kinase, HER2; PTKs catalyze the transfer of the ...
802-953 7.14e-36

Catalytic domain of the Protein Tyrosine Kinase, HER2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER2 (ErbB2, HER2/neu) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. HER2 does not bind to any known EGFR subfamily ligands, but contributes to the kinase activity of all possible heterodimers. It acts as the preferred partner of other ligand-bound EGFR proteins and functions as a signal amplifier, with the HER2-HER3 heterodimer being the most potent pair in mitogenic signaling. HER2 plays an important role in cell development, proliferation, survival and motility. Overexpression of HER2 results in its activation and downstream signaling, even in the absence of ligand. HER2 overexpression, mainly due to gene amplification, has been shown in a variety of human cancers. Its role in breast cancer is especially well-documented. HER2 is up-regulated in about 25% of breast tumors and is associated with increases in tumor aggressiveness, recurrence and mortality. HER2 is a target for monoclonal antibodies and small molecule inhibitors, which are being developed as treatments for cancer. The first humanized antibody approved for clinical use is Trastuzumab (Herceptin), which is being used in combination with other therapies to improve the survival rates of patients with HER2-overexpressing breast cancer. The HER2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270684 [Multi-domain]  Cd Length: 279  Bit Score: 137.85  E-value: 7.14e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  802 DLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-MRDSNYISKGSTfLPLKWMAPESIFNSLY 880
Cdd:cd05109   110 DLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLdIDETEYHADGGK-VPIKWMALESILHRRF 188
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982  881 TTLSDVWSFGILLWEIFTLGGTPYPELPMNDqFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05109   189 THQSDVWSYGVTVWELMTFGAKPYDGIPARE-IPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRE 260
PTKc_EphR_B cd05065
Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors; PTKs catalyze ...
606-953 4.55e-35

Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Class EphB receptors bind to transmembrane ephrin-B ligands. There are six vertebrate EphB receptors (EphB1-6), which display promiscuous interactions with three ephrin-B ligands. One exception is EphB2, which also interacts with ephrin A5. EphB receptors play important roles in synapse formation and plasticity, spine morphogenesis, axon guidance, and angiogenesis. In the intestinal epithelium, EphBs are Wnt signaling target genes that control cell compartmentalization. They function as suppressors of colon cancer progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). They contain an ephrin-binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion. The EphB subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173638 [Multi-domain]  Cd Length: 269  Bit Score: 135.00  E-value: 4.55e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATAHGLSHSQATmkVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITEYCR 685
Cdd:cd05065    12 IGAGEFGEVCRGRLKLPGKREIF--VAIKTLKSGYTEKQRRDFLSEASIMGQFD-HPNIIHLEGVVTKSRPVMIITEFME 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  686 YGDLVDYLHRNKHTFlqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgdikyad 765
Cdd:cd05065    89 NGALDSFLRQNDGQF----------------------------------------------------------------- 103
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  766 iespsymapydnyvpsapertyratlindspvlSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDF 845
Cdd:cd05065   104 ---------------------------------TVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDF 150
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  846 GLAR---DIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPmNDQFYNAIKRGYR 922
Cdd:cd05065   151 GLSRfleDDTSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMS-NQDVINAIEQDYR 229
                         330       340       350
                  ....*....|....*....|....*....|.
gi 226342982  923 MAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05065   230 LPPPMDCPTALHQLMLDCWQKDRNLRPKFGQ 260
PTKc_Jak1_rpt2 cd05079
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the ...
604-951 4.31e-34

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak1 is widely expressed in many tissues. Many cytokines are dependent on Jak1 for signaling, including those that use the shared receptor subunits common gamma chain (IL-2, IL-4, IL-7, IL-9, IL-15, IL-21) and gp130 (IL-6, IL-11, oncostatin M, G-CSF, and IFNs, among others). The many varied interactions of Jak1 and its ubiquitous expression suggest many biological roles. Jak1 is important in neurological development, as well as in lymphoid development and function. It also plays a role in the pathophysiology of cardiac hypertrophy and heart failure. A mutation in the ATP-binding site of Jak1 was identified in a human uterine leiomyosarcoma cell line, resulting in defective cytokine induction and antigen presentation, thus allowing the tumor to evade the immune system. Jak1 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Jak1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173644 [Multi-domain]  Cd Length: 284  Bit Score: 132.75  E-value: 4.31e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVvEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACTKGG--PIYIIT 681
Cdd:cd05079    10 RDLGEGHFGKV-ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-YHENIVKYKGICTEDGgnGIKLIM 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  682 EYCRYGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpSHLNLtgesdggymdmskdesidyvpmldmKGDI 761
Cdd:cd05079    88 EFLPSGSLKEYLPRNK------------------------------NKINL-------------------------KQQL 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  762 KYAdiespsymapydnyvpsapertyratlindspvlsytdlvgfsYQVANGMDFLASKNCVHRDLAARNVLICEGKLVK 841
Cdd:cd05079   113 KYA-------------------------------------------VQICKGMDYLGSRQYVHRDLAARNVLVESEHQVK 149
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  842 ICDFGLARDIMRDSNYIS-KGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPEL--------PMNDQ 912
Cdd:cd05079   150 IGDFGLTKAIETDKEYYTvKDDLDSPVFWYAPECLIQSKFYIASDVWSFGVTLYELLTYCDSESSPMtlflkmigPTHGQ 229
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 226342982  913 -----FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05079   230 mtvtrLVRVLEEGKRLPRPPNCPEEVYQLMRKCWEFQPSKRTTF 273
PTKc_Jak3_rpt2 cd05081
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the ...
778-953 5.07e-33

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak3 is expressed only in hematopoietic cells. It binds the shared receptor subunit common gamma chain and thus, is essential in the signaling of cytokines that use it such as IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Jak3 is important in lymphoid development and myeloid cell differentiation. Inactivating mutations in Jak3 have been reported in humans with severe combined immunodeficiency (SCID). Jak3 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270665 [Multi-domain]  Cd Length: 283  Bit Score: 129.63  E-value: 5.07e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  778 YVPSAPERTYratLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
Cdd:cd05081    88 YLPSGCLRDF---LQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDY 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  858 I---SKGSTflPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGG---TPYPEL-----PMNDQ-----FYNAIKRGY 921
Cdd:cd05081   165 YvvrEPGQS--PIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDkscSPSAEFlrmmgCERDVpalcrLLELLEEGQ 242
                         170       180       190
                  ....*....|....*....|....*....|..
gi 226342982  922 RMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05081   243 RLPAPPACPAEVHELMKLCWAPSPQDRPSFSA 274
PTKc_HER4 cd05110
Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the ...
803-953 1.30e-31

Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER4 (ErbB4) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands that bind HER4 fall into two groups, the neuregulins (or heregulins) and some EGFR (HER1) ligands including betacellulin, HBEGF, and epiregulin. All four neuregulins (NRG1-4) interact with HER4. Upon ligand binding, HER4 forms homo- or heterodimers with other HER proteins. HER4 is essential in embryonic development. It is implicated in mammary gland, cardiac, and neural development. As a postsynaptic receptor of NRG1, HER4 plays an important role in synaptic plasticity and maturation. The impairment of NRG1/HER4 signaling may contribute to schizophrenia. The HER4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173655 [Multi-domain]  Cd Length: 303  Bit Score: 125.95  E-value: 1.30e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  803 LVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTT 882
Cdd:cd05110   111 LLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTH 190
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226342982  883 LSDVWSFGILLWEIFTLGGTPYPELPMNdQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05110   191 QSDVWSYGVTIWELMTFGGKPYDGIPTR-EIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKE 260
PTKc_Jak2_rpt2 cd14205
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the ...
778-951 2.07e-31

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak2 is widely expressed in many tissues and is essential for the signaling of hormone-like cytokines such as growth hormone, erythropoietin, thrombopoietin, and prolactin, as well as some IFNs and cytokines that signal through the IL-3 and gp130 receptors. Disruption of Jak2 in mice results in an embryonic lethal phenotype with multiple defects including erythropoietic and cardiac abnormalities. It is the only Jak gene that results in a lethal phenotype when disrupted in mice. A mutation in the pseudokinase domain of Jak2, V617F, is present in many myeloproliferative diseases, including almost all patients with polycythemia vera, and 50% of patients with essential thrombocytosis and myelofibrosis. Jak2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271107 [Multi-domain]  Cd Length: 284  Bit Score: 124.74  E-value: 2.07e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  778 YVPSAPERTYratLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
Cdd:cd14205    88 YLPYGSLRDY---LQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEY 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  858 IS-KGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTL---GGTP---YPELPMNDQ--------FYNAIKRGYR 922
Cdd:cd14205   165 YKvKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYiekSKSPpaeFMRMIGNDKqgqmivfhLIELLKNNGR 244
                         170       180
                  ....*....|....*....|....*....
gi 226342982  923 MAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd14205   245 LPRPDGCPDEIYMIMTECWNNNVNQRPSF 273
STKc_MAPKKK cd06606
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase ...
599-940 3.13e-31

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKKKs (MKKKs or MAP3Ks) are also called MAP/ERK kinase kinases (MEKKs) in some cases. They phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. This subfamily is composed of the Apoptosis Signal-regulating Kinases ASK1 (or MAPKKK5) and ASK2 (or MAPKKK6), MEKK1, MEKK2, MEKK3, MEKK4, as well as plant and fungal MAPKKKs. Also included in this subfamily are the cell division control proteins Schizosaccharomyces pombe Cdc7 and Saccharomyces cerevisiae Cdc15. The MAPKKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270783 [Multi-domain]  Cd Length: 258  Bit Score: 123.40  E-value: 3.13e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  599 QLVLGRTLGSGAFGQVVEAtahgLSHSQATMkVAVKMLKSTARSSEK-QALMSELKIMSHLgPHLNVVNLLGACTKGGPI 677
Cdd:cd06606     1 RWKKGELLGKGSFGSVYLA----LNLDTGEL-MAVKEVELSGDSEEElEALEREIRILSSL-KHPNIVRYLGTERTENTL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  678 YIITEYCrygdlvdylhrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesDGGymdmskdeSIdyvpmldm 757
Cdd:cd06606    75 NIFLEYV----------------------------------------------------PGG--------SL-------- 86
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  758 kgdikyadiespsymapydnyvpsapertyrATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEG 837
Cdd:cd06606    87 -------------------------------ASLLKKFGKLPEPVVRKYTRQILEGLEYLHSNGIVHRDIKGANILVDSD 135
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  838 KLVKICDFGLARDI----MRDSNYISKGSTFlplkWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELpmnDQF 913
Cdd:cd06606   136 GVVKLADFGCAKRLaeiaTGEGTKSLRGTPY----WMAPEVIRGEGYGRAADIWSLGCTVIEMAT-GKPPWSEL---GNP 207
                         330       340       350
                  ....*....|....*....|....*....|....
gi 226342982  914 YNAIkrgYRMAQ-------PAHASDEIYEIMQKC 940
Cdd:cd06606   208 VAAL---FKIGSsgepppiPEHLSEEAKDFLRKC 238
PTK_HER3 cd05111
Pseudokinase domain of the Protein Tyrosine Kinase, HER3; HER3 (ErbB3) is a member of the EGFR ...
803-953 4.95e-30

Pseudokinase domain of the Protein Tyrosine Kinase, HER3; HER3 (ErbB3) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. HER3 contains an impaired tyr kinase domain, which lacks crucial residues for catalytic activity against exogenous substrates but is still able to bind ATP and autophosphorylate. HER3 binds the neuregulin ligands, NRG1 and NRG2, and it relies on its heterodimerization partners for activity following ligand binding. The HER2-HER3 heterodimer constitutes a high affinity co-receptor capable of potent mitogenic signaling. HER3 participates in a signaling pathway involved in the proliferation, survival, adhesion, and motility of tumor cells. The HER3 subfamily is part of a larger superfamily that includes other pseudokinases and the the catalytic domains of active kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173656 [Multi-domain]  Cd Length: 279  Bit Score: 120.83  E-value: 4.95e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  803 LVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTT 882
Cdd:cd05111   111 LLNWCVQIAKGMYYLEEHRMVHRNLAARNVLLKSPSQVQVADFGVADLLYPDDKKYFYSEAKTPIKWMALESIHFGKYTH 190
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226342982  883 LSDVWSFGILLWEIFTLGGTPY-----PELPmndqfyNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05111   191 QSDVWSYGVTVWEMMTFGAEPYagmrlAEVP------DLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKE 260
STKc_TAK1 cd14058
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated ...
606-953 1.14e-29

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAK1 is also known as mitogen-activated protein kinase kinase kinase 7 (MAPKKK7 or MAP3K7), TAK, or MEKK7. As a MAPKKK, it is an important mediator of cellular responses to extracellular signals. It regulates both the c-Jun N-terminal kinase and p38 MAPK cascades by activating the MAPK kinases, MKK4 and MKK3/6. In addition, TAK1 plays diverse roles in immunity and development, in different biological contexts, through many signaling pathways including TGFbeta/BMP, Wnt/Fz, and NF-kB. It is also implicated in the activation of the tumor suppressor kinase, LKB1. The TAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270960 [Multi-domain]  Cd Length: 253  Bit Score: 119.08  E-value: 1.14e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATAHGlshsqatMKVAVKMLKStarSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITEYCR 685
Cdd:cd14058     1 VGRGSFGVVCKARWRN-------QIVAVKIIES---ESEKKAFEVEVRQLSRVD-HPNIIKLYGACSNQKPVCLVMEYAE 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  686 YGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgdikyad 765
Cdd:cd14058    70 GGSLYNVLHGKE-------------------------------------------------------------------- 81
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  766 iespsymapydnyvpsapertyratlinDSPVLSYTDLVGFSYQVANGMDFLAS---KNCVHRDLAARNVLICE-GKLVK 841
Cdd:cd14058    82 ----------------------------PKPIYTAAHAMSWALQCAKGVAYLHSmkpKALIHRDLKPPNLLLTNgGTVLK 133
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  842 ICDFGLARDImrdSNYIS--KGStflpLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLgGTPYPEL--PmNDQFYNAI 917
Cdd:cd14058   134 ICDFGTACDI---STHMTnnKGS----AAWMAPEVFEGSKYSEKCDVFSWGIILWEVITR-RKPFDHIggP-AFRIMWAV 204
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 226342982  918 KRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14058   205 HNGERPPLIKNCPKPIESLMTRCWSKDPEKRPSMKE 240
PTKc_EphR_A10 cd05064
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A10; PTKs catalyze the ...
594-953 5.43e-29

Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A10; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EphA10, which contains an inactive tyr kinase domain, may function to attenuate signals of co-clustered active receptors. EphA10 is mainly expressed in the testis. Ephrin/EphR interaction results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. EphRs comprise the largest subfamily of receptor tyr kinases (RTKs). In general, class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). The EphA10 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133195 [Multi-domain]  Cd Length: 266  Bit Score: 117.33  E-value: 5.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  594 ELPRDQLVLGRTLGSGAFGQVVEATAHglSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTK 673
Cdd:cd05064     1 ELDNKSIKIERILGTGRFGELCRGCLK--LPSKRELPVAIHTLRAGCSDKQRRGFLAEALTLGQFD-HSNIVRLEGVITR 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  674 GGPIYIITEYCRYGDLvdylhrnkHTFLQRHSNKhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvp 753
Cdd:cd05064    78 GNTMMIVTEYMSNGAL--------DSFLRKHEGQ---------------------------------------------- 103
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  754 mldmkgdikyadiespsymapydnyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVL 833
Cdd:cd05064   104 --------------------------------------------LVAGQLMGMLPGLASGMKYLSEMGYVHKGLAAHKVL 139
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  834 ICEGKLVKICDFG-LARDIMRDSNYISKGSTflPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDq 912
Cdd:cd05064   140 VNSDLVCKISGFRrLQEDKSEAIYTTMSGKS--PVLWAAPEAIQYHHFSSASDVWSFGIVMWEVMSYGERPYWDMSGQD- 216
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 226342982  913 FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05064   217 VIKAVEDGFRLPAPRNCPNLLHQLMLDCWQKERGERPRFSQ 257
IgI_VEGFR_like cd05742
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and ...
211-309 1.66e-28

Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins; member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and related proteins. The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. The VEGFR family consists of three members: VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1) and VEGFR-3 (Flt-4). VEGF-A interacts with both VEGFR-1 and VEGFR-2. VEGFR-1 binds strongest to VEGF; VEGF-2 binds more weakly. VEGFR-3 appears not to bind VEGF, but binds other members of the VEGF family (VEGF-C and -D). VEGFRs bind VEGFs with high affinity with the IG-like domains. VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGFR-2 is a major mediator of the mitogenic, angiogenic, and microvascular permeability-enhancing effects of VEGF-A. VEGFR-1 may play an inhibitory part in these processes by binding VEGF and interfering with its interaction with VEGFR-2. VEGFR-1 has a signaling role in mediating monocyte chemotaxis. VEGFR-1 and VEGFR-2 may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. VEGFR-3 has been shown to be involved in tumor angiogenesis and growth. This group also contains alpha-type platelet-derived growth factor receptor precursor (PDGFR)-alpha (CD140a), and PDGFR-beta (CD140b). PDGFRs alpha and beta have an extracellular component with five Ig-like domains, a transmembrane segment, and a cytoplasmic portion that has protein tyrosine kinase activity.


Pssm-ID: 409404  Cd Length: 102  Bit Score: 110.32  E-value: 1.66e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  211 SSINVSVNAVQTVVRQGESITIRCIVMG--NDVVNFQWTYPRMKSGRLVEPVTDYL--FGVPSRIGSILHIPTAELSDSG 286
Cdd:cd05742     1 SDLELSPNAEPTVLPQGETLVLNCTANVnlNEVVDFQWTYPSEKEGKLALLKPDIKvdWSEPGEFVSTLTIPEATLKDSG 80
                          90       100
                  ....*....|....*....|...
gi 226342982  287 TYTCNVSVSVndHGDEKAINISV 309
Cdd:cd05742    81 TYTCAARSGV--MKKEKQTSVSV 101
STKc_MLK2 cd14148
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the ...
803-952 5.87e-27

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK2 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K10. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK2 is abundant in brain, skeletal muscle, and testis. It functions upstream of the MAPK, c-Jun N-terminal kinase. It binds hippocalcin, a calcium-sensor protein that protects neurons against calcium-induced cell death. Both MLK2 and hippocalcin may be associated with the pathogenesis of Parkinson's disease. MLK2 also binds to normal huntingtin (Htt), which is important in neuronal transcription, development, and survival. MLK2 does not bind to the polyglutamine-expanded Htt, which is implicated in the pathogeneis of Huntington's disease, leading to neuronal toxicity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271050 [Multi-domain]  Cd Length: 258  Bit Score: 111.23  E-value: 5.87e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  803 LVGFSYQVANGMDFLASKNCV---HRDLAARNVLICE--------GKLVKICDFGLARDIMRDSNyISKGSTFlplKWMA 871
Cdd:cd14148    94 LVNWAVQIARGMNYLHNEAIVpiiHRDLKSSNILILEpienddlsGKTLKITDFGLAREWHKTTK-MSAAGTY---AWMA 169
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  872 PESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd14148   170 PEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDF 248

                  .
gi 226342982  952 S 952
Cdd:cd14148   249 G 249
STKc_MAP3K12_13 cd14059
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase ...
791-953 1.86e-26

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K12 is also called MAPK upstream kinase (MUK), dual leucine zipper-bearing kinase (DLK) or leucine-zipper protein kinase (ZPK). It is involved in the c-Jun N-terminal kinase (JNK) pathway that directly regulates axonal regulation through the phosphorylation of microtubule-associated protein 1B (MAP1B). It also regulates the differentiation of many cell types including adipocytes and may play a role in adipogenesis. MAP3K13, also called leucine zipper-bearing kinase (LZK), directly phosphorylates and activates MKK7, which in turn activates the JNK pathway. It also activates NF-kB through IKK activation and this activity is enhanced by antioxidant protein-1 (AOP-1). MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAP2Ks (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K12/13 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270961 [Multi-domain]  Cd Length: 237  Bit Score: 109.12  E-value: 1.86e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  791 LINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTflpLKWM 870
Cdd:cd14059    71 VLRAGREITPSLLVDWSKQIASGMNYLHLHKIIHRDLKSPNVLVTYNDVLKISDFGTSKELSEKSTKMSFAGT---VAWM 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  871 APESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPP 950
Cdd:cd14059   148 APEVIRNEPCSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLQLPVPSTCPDGFKLLMKQCWNSKPRNRPS 226

                  ...
gi 226342982  951 FSQ 953
Cdd:cd14059   227 FRQ 229
PTKc_Aatyk3 cd14206
Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3; PTKs ...
606-950 1.04e-25

Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Aatyk3, also called lemur tyrosine kinase 3 (Lmtk3) is a receptor kinase containing a transmembrane segment and a long C-terminal cytoplasmic tail with a catalytic domain. The function of Aatyk3 is still unknown. The Aatyk3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271108 [Multi-domain]  Cd Length: 276  Bit Score: 108.12  E-value: 1.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATahgLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACTKGGPIYIITEYCR 685
Cdd:cd14206     5 IGNGWFGKVILGE---IFSDYTPAQVVVKELRVSAGPLEQRKFISEAQPYRSL-QHPNILQCLGLCTETIPFLLIMEFCQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  686 YGDLVDYLHRnkhtflQRhsnkhcppsaelysnalpvgfslpshlnltgESDGgymdmskdesidyvpmldmkgdikyad 765
Cdd:cd14206    81 LGDLKRYLRA------QR-------------------------------KADG--------------------------- 96
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  766 iespsyMAPydnyvpsapertyratlinDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDF 845
Cdd:cd14206    97 ------MTP-------------------DLPTRDLRTLQRMAYEITLGLLHLHKNNYIHSDLALRNCLLTSDLTVRIGDY 151
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  846 GLARDIMRDSNYISKGSTFLPLKWMAPEsIFNSLYTTL--------SDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAI 917
Cdd:cd14206   152 GLSHNNYKEDYYLTPDRLWIPLRWVAPE-LLDELHGNLivvdqskeSNVWSLGVTIWELFEFGAQPYRHLSDEEVLTFVV 230
                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 226342982  918 K-RGYRMAQPA---HASDEIYEIMQKCWeekfetRPP 950
Cdd:cd14206   231 ReQQMKLAKPRlklPYADYWYEIMQSCW------LPP 261
STKc_MLK cd14061
Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the ...
803-953 2.16e-25

Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLKs act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Mammals have four MLKs (MLK1-4), mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270963 [Multi-domain]  Cd Length: 258  Bit Score: 106.71  E-value: 2.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  803 LVGFSYQVANGMDFLASKNCV---HRDLAARNVLICEG--------KLVKICDFGLARDIMRdSNYISKGSTFlplKWMA 871
Cdd:cd14061    94 LVDWAIQIARGMNYLHNEAPVpiiHRDLKSSNILILEAienedlenKTLKITDFGLAREWHK-TTRMSAAGTY---AWMA 169
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  872 PESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELpmndqfyNAIKRGYRMAQ-------PAHASDEIYEIMQKCWEEK 944
Cdd:cd14061   170 PEVIKSSTFSKASDVWSYGVLLWELLT-GEVPYKGI-------DGLAVAYGVAVnkltlpiPSTCPEPFAQLMKDCWQPD 241

                  ....*....
gi 226342982  945 FETRPPFSQ 953
Cdd:cd14061   242 PHDRPSFAD 250
PTKc_Tyk2_rpt2 cd05080
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze ...
604-951 7.08e-25

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tyk2 is widely expressed in many tissues. It is involved in signaling via the cytokine receptors IFN-alphabeta, IL-6, IL-10, IL-12, IL-13, and IL-23. It mediates cell surface urokinase receptor (uPAR) signaling and plays a role in modulating vascular smooth muscle cell (VSMC) functional behavior in response to injury. Tyk2 is also important in dendritic cell function and T helper (Th)1 cell differentiation. A homozygous mutation of Tyk2 was found in a patient with hyper-IgE syndrome (HIES), a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and elevated serum IgE. This suggests that Tyk2 may play important roles in multiple cytokine signaling involved in innate and adaptive immunity. Tyk2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Tyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270664 [Multi-domain]  Cd Length: 283  Bit Score: 105.75  E-value: 7.08e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEATAHGLSHSQATMkVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGP--IYIIT 681
Cdd:cd05080    10 RDLGEGHFGKVSLYCYDPTNDGTGEM-VAVKALKADCGPQHRSGWKQEIDILKTLY-HENIVKYKGCCSEQGGksLQLIM 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  682 EYCRYGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgdi 761
Cdd:cd05080    88 EYVPLGSLRDYLPKHS---------------------------------------------------------------- 103
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  762 kyadiespsymapydnyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVK 841
Cdd:cd05080   104 ------------------------------------IGLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVK 147
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  842 ICDFGLARDIMRDSNYI---SKGSTflPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGG------TPYPEL--PMN 910
Cdd:cd05080   148 IGDFGLAKAVPEGHEYYrvrEDGDS--PVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDssqsppTKFLEMigIAQ 225
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 226342982  911 DQ-----FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05080   226 GQmtvvrLIELLERGERLPCPDKCPQEVYHLMKNCWETEASFRPTF 271
PKc_STE cd05122
Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the ...
602-949 8.37e-25

Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. This family is composed of STKs, and some dual-specificity PKs that phosphorylate both threonine and tyrosine residues of target proteins. Most members are kinases involved in mitogen-activated protein kinase (MAPK) signaling cascades, acting as MAPK kinases (MAPKKs), MAPKK kinases (MAPKKKs), or MAPKKK kinases (MAP4Ks). The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPKK, which itself is phosphorylated and activated by a MAPKKK. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAPKKK to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Other STE family members include p21-activated kinases (PAKs) and class III myosins, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain, which can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, as well as autophosphorylate the C-terminal motor domain. They play an important role in maintaining the structural integrity of photoreceptor cell microvilli. The STE family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270692 [Multi-domain]  Cd Length: 254  Bit Score: 104.59  E-value: 8.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  602 LGRTLGSGAFGQVVEATahglsHSQATMKVAVKMLKsTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIIT 681
Cdd:cd05122     4 ILEKIGKGGFGVVYKAR-----HKKTGQIVAIKKIN-LESKEKKESILNEIAILKKCK-HPNIVKYYGSYLKKDELWIVM 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  682 EYCRYGDLVDYLHRNKHTFlqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskDESidyvpmldmkgDI 761
Cdd:cd05122    77 EFCSGGSLKDLLKNTNKTL---------------------------------------------TEQ-----------QI 100
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  762 KYadiespsymapydnyvpsaperTYRATLindspvlsytdlvgfsyqvaNGMDFLASKNCVHRDLAARNVLICEGKLVK 841
Cdd:cd05122   101 AY----------------------VCKEVL--------------------KGLEYLHSHGIIHRDIKAANILLTSDGEVK 138
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  842 ICDFGLARDIMRDSNYISK-GSTFlplkWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPEL-PMNDQFYNAIKR 919
Cdd:cd05122   139 LIDFGLSAQLSDGKTRNTFvGTPY----WMAPEVIQGKPYGFKADIWSLGITAIEMAE-GKPPYSELpPMKALFLIATNG 213
                         330       340       350
                  ....*....|....*....|....*....|
gi 226342982  920 GYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd05122   214 PPGLRNPKKWSKEFKDFLKKCLQKDPEKRP 243
STKc_MLK4 cd14146
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the ...
803-952 1.33e-24

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK4 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The specific function of MLK4 is yet to be determined. Mutations in the kinase domain of MLK4 have been detected in colorectal cancers. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271048 [Multi-domain]  Cd Length: 268  Bit Score: 104.73  E-value: 1.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  803 LVGFSYQVANGMDFLASKNCV---HRDLAARNVLICE--------GKLVKICDFGLARDIMRDSNYISKGStflpLKWMA 871
Cdd:cd14146   104 LVNWAVQIARGMLYLHEEAVVpilHRDLKSSNILLLEkiehddicNKTLKITDFGLAREWHRTTKMSAAGT----YAWMA 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  872 PESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd14146   180 PEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSF 258

                  .
gi 226342982  952 S 952
Cdd:cd14146   259 A 259
STKc_MLK1 cd14145
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the ...
803-952 4.52e-24

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK1 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K9. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Little is known about the specific function of MLK1. It is capable of activating the c-Jun N-terminal kinase pathway. Mice lacking both MLK1 and MLK2 are viable, fertile, and have normal life spans. There could be redundancy in the function of MLKs. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271047 [Multi-domain]  Cd Length: 270  Bit Score: 103.20  E-value: 4.52e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  803 LVGFSYQVANGMDFLASKNCV---HRDLAARNVLICE--------GKLVKICDFGLARDIMRDSNYISKGStflpLKWMA 871
Cdd:cd14145   106 LVNWAVQIARGMNYLHCEAIVpviHRDLKSSNILILEkvengdlsNKILKITDFGLAREWHRTTKMSAAGT----YAWMA 181
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  872 PESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd14145   182 PEVIRSSMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLSLPIPSTCPEPFARLMEDCWNPDPHSRPPF 260

                  .
gi 226342982  952 S 952
Cdd:cd14145   261 T 261
STKc_Raf cd14062
Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) ...
606-953 1.07e-23

Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Raf kinases act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. Aberrant expression or activation of components in this pathway are associated with tumor initiation, progression, and metastasis. Raf proteins contain a Ras binding domain, a zinc finger cysteine-rich domain, and a catalytic kinase domain. Vertebrates have three Raf isoforms (A-, B-, and C-Raf) with different expression profiles, modes of regulation, and abilities to function in the ERK cascade, depending on cellular context and stimuli. They have essential and non-overlapping roles during embryo- and organogenesis. Knockout of each isoform results in a lethal phenotype or abnormality in most mouse strains. The Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270964 [Multi-domain]  Cd Length: 253  Bit Score: 101.70  E-value: 1.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATAHGlshsqatmKVAVKMLKSTARSSEK-QALMSELKIMSHLgPHLNVVNLLGACTKGGpIYIITEYC 684
Cdd:cd14062     1 IGSGSFGTVYKGRWHG--------DVAVKKLNVTDPTPSQlQAFKNEVAVLRKT-RHVNILLFMGYMTKPQ-LAIVTQWC 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  685 RygdlvdylhrnkhtflqrhsnkhcppsaelysnalpvGFSLPSHLNltgesdggymdmskdesidyvpMLDMKGDIkya 764
Cdd:cd14062    71 E-------------------------------------GSSLYKHLH----------------------VLETKFEM--- 88
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  765 diespsymapydnyvpsapertyrATLINdspvlsytdlvgFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICD 844
Cdd:cd14062    89 ------------------------LQLID------------IARQTAQGMDYLHAKNIIHRDLKSNNIFLHEDLTVKIGD 132
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  845 FGLARDIMRDS----NYISKGSTFlplkWMAPESIFN---SLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAI 917
Cdd:cd14062   133 FGLATVKTRWSgsqqFEQPTGSIL----WMAPEVIRMqdeNPYSFQSDVYAFGIVLYELLT-GQLPYSHINNRDQILFMV 207
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 226342982  918 KRGYRMAQPAHA-SD---EIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14062   208 GRGYLRPDLSKVrSDtpkALRRLMEDCIKFQRDERPLFPQ 247
PTKc_Aatyk1 cd05087
Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1; PTKs ...
604-949 3.98e-23

Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Aatyk1 (or simply Aatyk) is also called lemur tyrosine kinase 1 (Lmtk1). It is a cytoplasmic (or nonreceptor) kinase containing a long C-terminal region. The expression of Aatyk1 is upregulated during growth arrest and apoptosis in myeloid cells. Aatyk1 has been implicated in neural differentiation, and is a regulator of the Na-K-2Cl cotransporter, a membrane protein involved in cell proliferation and survival, epithelial transport, and blood pressure control. The Aatyk1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270670 [Multi-domain]  Cd Length: 271  Bit Score: 100.45  E-value: 3.98e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEATAH-GLSHSQatmkVAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACTKGGPIYIITE 682
Cdd:cd05087     3 KEIGHGWFGKVFLGEVNsGLSSTQ----VVVKELKASASVQDQMQFLEEAQPYRAL-QHTNLLQCLAQCAEVTPYLLVME 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  683 YCRYGDLVDYLhrnkhtflqrhsnKHCppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgdik 762
Cdd:cd05087    78 FCPLGDLKGYL-------------RSC----------------------------------------------------- 91
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  763 yadiESPSYMAPydnyvpsapertyratlindSPVLsytdLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKI 842
Cdd:cd05087    92 ----RAAESMAP--------------------DPLT----LQRMACEVACGLLHLHRNNFVHSDLALRNCLLTADLTVKI 143
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  843 CDFGLARDIMRDSNYISKGSTFLPLKWMAPESI----FNSLY---TTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYN 915
Cdd:cd05087   144 GDYGLSHCKYKEDYFVTADQLWVPLRWIAPELVdevhGNLLVvdqTKQSNVWSLGVTIWELFELGNQPYRHYSDRQVLTY 223
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 226342982  916 AIK-RGYRMAQPA---HASDEIYEIMQKCWEEKfETRP 949
Cdd:cd05087   224 TVReQQLKLPKPQlklSLAERWYEVMQFCWLQP-EQRP 260
STKc_RIP cd13978
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze ...
606-951 4.21e-23

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP kinases serve as essential sensors of cellular stress. They are involved in regulating NF-kappaB and MAPK signaling, and are implicated in mediating cellular processes such as apoptosis, necroptosis, differentiation, and survival. RIP kinases contain a homologous N-terminal kinase domain and varying C-terminal domains. Higher vertebrates contain multiple RIP kinases, with mammals harboring at least five members. RIP1 and RIP2 harbor C-terminal domains from the Death domain (DD) superfamily while RIP4 contains ankyrin (ANK) repeats. RIP3 contain a RIP homotypic interaction motif (RHIM) that facilitates binding to RIP1. RIP1 and RIP3 are important in apoptosis and necroptosis, while RIP2 and RIP4 play roles in keratinocyte differentiation and inflammatory immune responses. The RIP subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270880 [Multi-domain]  Cd Length: 263  Bit Score: 100.22  E-value: 4.21e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVveataHGLSHSQATMKVAVKMLKS-TARSSEKQALMSELKIMsHLGPHLNVVNLLGACTKGGPIYIITEYC 684
Cdd:cd13978     1 LGSGGFGTV-----SKARHVSWFGMVAIKCLHSsPNCIEERKALLKEAEKM-ERARHSYVLPLLGVCVERRSLGLVMEYM 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  685 RYGDLVDYLHRnkhtflqrhsnkhcppsaELYSNALPVGFSlpshlnltgesdggymdmskdesidyvpmldmkgdikya 764
Cdd:cd13978    75 ENGSLKSLLER------------------EIQDVPWSLRFR--------------------------------------- 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  765 diespsymapydnyvpsapertyratlindspvlsytdlvgFSYQVANGMDFL--ASKNCVHRDLAARNVLICEGKLVKI 842
Cdd:cd13978    98 -----------------------------------------IIHEIALGMNFLhnMDPPLLHHDLKPENILLDNHFHVKI 136
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  843 CDFGLARDIMR---DSNYISKGSTFLPLKWMAPESI--FNSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAI 917
Cdd:cd13978   137 SDFGLSKLGMKsisANRRRGTENLGGTPIYMAPEAFddFNKKPTSKSDVYSFAIVIWAVLT-RKEPFENAINPLLIMQIV 215
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 226342982  918 KRGYR-------MAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd13978   216 SKGDRpslddigRLKQIENVQELISLMIRCWDGNPDARPTF 256
STKc_B-Raf cd14151
Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) ...
593-953 4.34e-23

Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. B-Raf activates ERK with the strongest magnitude, compared with other Raf kinases. Mice embryos deficient in B-Raf die around midgestation due to vascular hemorrhage caused by apoptotic endothelial cells. Mutations in B-Raf have been implicated in initiating tumorigenesis and tumor progression, and are found in malignant cutaneous melanoma, papillary thyroid cancer, as well as in ovarian and colorectal carcinomas. Most oncogenic B-Raf mutations are located at the activation loop of the kinase and surrounding regions; the V600E mutation accounts for around 90% of oncogenic mutations. The V600E mutant constitutively activates MEK, resulting in sustained activation of ERK. B-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The B-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271053 [Multi-domain]  Cd Length: 274  Bit Score: 100.52  E-value: 4.34e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGlshsqatmKVAVKMLKSTARSSEK-QALMSELKIMSHLgPHLNVVNLLGAC 671
Cdd:cd14151     3 WEIPDGQITVGQRIGSGSFGTVYKGKWHG--------DVAVKMLNVTAPTPQQlQAFKNEVGVLRKT-RHVNILLFMGYS 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  672 TKGgPIYIITEYCRYGDLVDYLHRNKHTFlqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymDMSKdesidy 751
Cdd:cd14151    74 TKP-QLAIVTQWCEGSSLYHHLHIIETKF-----------------------------------------EMIK------ 105
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  752 vpmldmkgdikyadiespsymapydnyvpsapertyratlindspvlsytdLVGFSYQVANGMDFLASKNCVHRDLAARN 831
Cdd:cd14151   106 ---------------------------------------------------LIDIARQTAQGMDYLHAKSIIHRDLKSNN 134
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  832 VLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIF---NSLYTTLSDVWSFGILLWEIFTlGGTPYPELP 908
Cdd:cd14151   135 IFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRmqdKNPYSFQSDVYAFGIVLYELMT-GQLPYSNIN 213
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 226342982  909 MNDQFYNAIKRGYRMAQ----PAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14151   214 NRDQIIFMVGRGYLSPDlskvRSNCPKAMKRLMAECLKKKRDERPLFPQ 262
STKc_A-Raf cd14150
Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) ...
599-953 6.02e-23

Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. A-Raf cooperates with C-Raf in regulating ERK transient phosphorylation that is associated with cyclin D expression and cell cycle progression. Mice deficient in A-Raf are born alive but show neurological and intestinal defects. A-Raf demonstrates low kinase activity to MEK, compared with B- and C-Raf, and may also have alternative functions other than in the ERK signaling cascade. It regulates the M2 type pyruvate kinase, a key glycolytic enzyme. It also plays a role in endocytic membrane trafficking. A-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The A-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271052 [Multi-domain]  Cd Length: 265  Bit Score: 99.71  E-value: 6.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  599 QLVLGRTLGSGAFGQVVEATAHGlshsqatmKVAVKMLKSTARSSEK-QALMSELKIMSHLgPHLNVVNLLGACTKGGpI 677
Cdd:cd14150     1 EVSMLKRIGTGSFGTVFRGKWHG--------DVAVKILKVTEPTPEQlQAFKNEMQVLRKT-RHVNILLFMGFMTRPN-F 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  678 YIITEYCRygdlvdylhrnkhtflqrhsnkhcppsaelysnalpvGFSLPSHLNLTgesdggymdmskDESIDYVPMLDM 757
Cdd:cd14150    71 AIITQWCE-------------------------------------GSSLYRHLHVT------------ETRFDTMQLIDV 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  758 kgdikyadiespsymapydnyvpsapertyratlindspvlsytdlvgfSYQVANGMDFLASKNCVHRDLAARNVLICEG 837
Cdd:cd14150   102 -------------------------------------------------ARQTAQGMDYLHAKNIIHRDLKSNNIFLHEG 132
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  838 KLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIF---NSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFY 914
Cdd:cd14150   133 LTVKIGDFGLATVKTRWSGSQQVEQPSGSILWMAPEVIRmqdTNPYSFQSDVYAYGVVLYELMS-GTLPYSNINNRDQII 211
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 226342982  915 NAIKRGYRMAQPAHASDEIYEIMQK----CWEEKFETRPPFSQ 953
Cdd:cd14150   212 FMVGRGYLSPDLSKLSSNCPKAMKRllidCLKFKREERPLFPQ 254
PTKc_Aatyk cd05042
Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinases; PTKs ...
606-949 1.42e-22

Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Aatyk subfamily is also referred to as the lemur tyrosine kinase (Lmtk) subfamily. It consists of Aatyk1 (Lmtk1), Aatyk2 (Lmtk2, Brek), Aatyk3 (Lmtk3), and similar proteins. Aatyk proteins are mostly receptor PTKs (RTKs) containing a transmembrane segment and a long C-terminal cytoplasmic tail with a catalytic domain. Aatyk1 does not contain a transmembrane segment and is a cytoplasmic (or nonreceptor) kinase. Aatyk proteins are classified as PTKs based on overall sequence similarity and the phylogenetic tree. However, analysis of catalytic residues suggests that Aatyk proteins may be multispecific kinases, functioning also as serine/threonine kinases. They are involved in neural differentiation, nerve growth factor (NGF) signaling, apoptosis, and spermatogenesis. The Aatyk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270638 [Multi-domain]  Cd Length: 269  Bit Score: 98.81  E-value: 1.42e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATAH-GLSHSQatmkVAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACTKGGPIYIITEYC 684
Cdd:cd05042     3 IGNGWFGKVLLGEIYsGTSVAQ----VVVKELKASANPKEQDTFLKEGQPYRIL-QHPNILQCLGQCVEAIPYLLVMEFC 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  685 RYGDLVDYLhrnkhtflqrhsnKHCPPSaelysnalpvgfslpshlnltgesdggymdmskdESIDYVPMLdmkgdikya 764
Cdd:cd05042    78 DLGDLKAYL-------------RSEREH----------------------------------ERGDSDTRT--------- 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  765 diespsymapydnyvpsapertyratlindspvlsytdLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICD 844
Cdd:cd05042   102 --------------------------------------LQRMACEVAAGLAHLHKLNFVHSDLALRNCLLTSDLTVKIGD 143
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  845 FGLARDIMRDSNYISKGSTFLPLKWMAPEsIFNSLYTTL--------SDVWSFGILLWEIFTLGGTPYPELPMNDQFYNA 916
Cdd:cd05042   144 YGLAHSRYKEDYIETDDKLWFPLRWTAPE-LVTEFHDRLlvvdqtkySNIWSLGVTLWELFENGAQPYSNLSDLDVLAQV 222
                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 226342982  917 IK-RGYRMAQPAHA---SDEIYEIMQKCWEEKfETRP 949
Cdd:cd05042   223 VReQDTKLPKPQLElpySDRWYEVLQFCWLSP-EQRP 258
STKc_MLTK cd14060
Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated ...
764-953 2.11e-22

Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLTK, also called zipper sterile-alpha-motif kinase (ZAK), contains a catalytic kinase domain and a leucine zipper. There are two alternatively-spliced variants, MLTK-alpha and MLTK-beta. MLTK-alpha contains a sterile-alpha-motif (SAM) at the C-terminus. MLTK regulates the c-Jun N-terminal kinase, extracellular signal-regulated kinase, p38 MAPK, and NF-kB pathways. ZAK is the MAP3K involved in the signaling cascade that leads to the ribotoxic stress response initiated by cellular damage due to Shiga toxins and ricin. It may also play a role in cell transformation and cancer development. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals.The MLTK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270962 [Multi-domain]  Cd Length: 242  Bit Score: 97.34  E-value: 2.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  764 ADIESPSYmAPYDNYVPSAPERTYRATliNDSPVLSYTDLVGFSYQVANGMDFL---ASKNCVHRDLAARNVLICEGKLV 840
Cdd:cd14060    50 AILEAPNY-GIVTEYASYGSLFDYLNS--NESEEMDMDQIMTWATDIAKGMHYLhmeAPVKVIHRDLKSRNVVIAADGVL 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  841 KICDFGLARdIMRDSNYISKGSTFlplKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLgGTPYPELPMNDQFYNAIKRG 920
Cdd:cd14060   127 KICDFGASR-FHSHTTHMSLVGTF---PWMAPEVIQSLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKN 201
                         170       180       190
                  ....*....|....*....|....*....|...
gi 226342982  921 YRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14060   202 ERPTIPSSCPRSFAELMRRCWEADVKERPSFKQ 234
STKc_Cdc7_like cd06627
Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs ...
602-949 2.64e-22

Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include Schizosaccharomyces pombe Cdc7, Saccharomyces cerevisiae Cdc15, Arabidopsis thaliana mitogen-activated protein kinase kinase kinase (MAPKKK) epsilon, and related proteins. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Cdc7 is essential for cell division by playing a key role in the initiation of septum formation and cytokinesis. Budding yeast Cdc15 functions to coordinate mitotic exit with cytokinesis. Arabidopsis MAPKKK epsilon is required for pollen development in the plasma membrane. The Cdc7-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270797 [Multi-domain]  Cd Length: 254  Bit Score: 97.68  E-value: 2.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  602 LGRTLGSGAFGQVVEatahGLSHSQATMkVAVKMLKSTARSSEK-QALMSELKIMSHLGpHLNVVNLLGACTKGGPIYII 680
Cdd:cd06627     4 LGDLIGRGAFGSVYK----GLNLNTGEF-VAIKQISLEKIPKSDlKSVMGEIDLLKKLN-HPNIVKYIGSVKTKDSLYII 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  681 TEYCRYGDLvdylhrnkHTFLQRHSNkhcppsaelysnalpvgfsLPSHLnltgesdggymdmskdesidyvpmldmkgd 760
Cdd:cd06627    78 LEYVENGSL--------ASIIKKFGK-------------------FPESL------------------------------ 100
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  761 ikyadiespsymapydnyvpsapertyratlindspVLSYTdlvgfsYQVANGMDFLASKNCVHRDLAARNVLICEGKLV 840
Cdd:cd06627   101 ------------------------------------VAVYI------YQVLEGLAYLHEQGVIHRDIKGANILTTKDGLV 138
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  841 KICDFGLARDIMRdsnyiSKGSTFLPL---KWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPEL-PMNDQFynA 916
Cdd:cd06627   139 KLADFGVATKLNE-----VEKDENSVVgtpYWMAPEVIEMSGVTTASDIWSVGCTVIELLT-GNPPYYDLqPMAALF--R 210
                         330       340       350
                  ....*....|....*....|....*....|...
gi 226342982  917 IKRGYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd06627   211 IVQDDHPPLPENISPELRDFLLQCFQKDPTLRP 243
STKc_AMPK-like cd14003
Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze ...
601-949 3.08e-22

Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The AMPK-like subfamily is composed of AMPK, MARK, BRSK, NUAK, MELK, SNRK, TSSK, and SIK, among others. LKB1 serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. BRSKs play important roles in establishing neuronal polarity. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. The AMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270905 [Multi-domain]  Cd Length: 252  Bit Score: 97.20  E-value: 3.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  601 VLGRTLGSGAFGQVVEATahglsHSQATMKVAVKML-KSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYI 679
Cdd:cd14003     3 ELGKTLGEGSFGKVKLAR-----HKLTGEKVAIKIIdKSKLKEEIEEKIKREIEIMKLLN-HPNIIKLYEVIETENKIYL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  680 ITEYCRYGDLVDYLHRNkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdgGYMDmskdesidyvpmldmkg 759
Cdd:cd14003    77 VMEYASGGELFDYIVNN------------------------------------------GRLS----------------- 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  760 dikyadiespsymapydnyvpsapERTYRAtlindspvlsytdlvgFSYQVANGMDFLASKNCVHRDLAARNVLICEGKL 839
Cdd:cd14003    98 ------------------------EDEARR----------------FFQQLISAVDYCHSNGIVHRDLKLENILLDKNGN 137
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  840 VKICDFGLARDIMRDSN-YISKGSTFlplkWMAPESIFNSLY-TTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAI 917
Cdd:cd14003   138 LKIIDFGLSNEFRGGSLlKTFCGTPA----YAAPEVLLGRKYdGPKADVWSLGVILYAMLT-GYLPFDDDNDSKLFRKIL 212
                         330       340       350
                  ....*....|....*....|....*....|..
gi 226342982  918 KRGYRMaqPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd14003   213 KGKYPI--PSHLSPDARDLIRRMLVVDPSKRI 242
STKc_MLK3 cd14147
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the ...
803-952 1.56e-21

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK3 is a mitogen-activated protein kinase kinase kinases (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK3 activates multiple MAPK pathways and plays a role in apoptosis, proliferation, migration, and differentiation, depending on the cellular context. It is highly expressed in breast cancer cells and its signaling through c-Jun N-terminal kinase has been implicated in the migration, invasion, and malignancy of cancer cells. MLK3 also functions as a negative regulator of Inhibitor of Nuclear Factor-KappaB Kinase (IKK) and consequently, it also impacts inflammation and immunity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271049 [Multi-domain]  Cd Length: 267  Bit Score: 95.48  E-value: 1.56e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  803 LVGFSYQVANGMDFLASKNCV---HRDLAARNVLIC--------EGKLVKICDFGLARDIMRDSNYISKGStflpLKWMA 871
Cdd:cd14147   103 LVNWAVQIARGMHYLHCEALVpviHRDLKSNNILLLqpienddmEHKTLKITDFGLAREWHKTTQMSAAGT----YAWMA 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  872 PESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd14147   179 PEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDF 257

                  .
gi 226342982  952 S 952
Cdd:cd14147   258 A 258
STKc_Aurora cd14007
Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of ...
602-953 3.59e-21

Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Yeast contains only one Aurora kinase while most higher eukaryotes have two. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2. Aurora-B is most active at the transition during metaphase to the end of mitosis. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270909 [Multi-domain]  Cd Length: 253  Bit Score: 94.08  E-value: 3.59e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  602 LGRTLGSGAFGQVVEATahglsHSQATMKVAVKML-KSTARSS--EKQaLMSELKIMSHLGpHLNVVNLLGACTKGGPIY 678
Cdd:cd14007     4 IGKPLGKGKFGNVYLAR-----EKKSGFIVALKVIsKSQLQKSglEHQ-LRREIEIQSHLR-HPNILRLYGYFEDKKRIY 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  679 IITEYCRYGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmk 758
Cdd:cd14007    77 LILEYAPNGELYKELKKQK------------------------------------------------------------- 95
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  759 gdiKYADIESPSYMapydnyvpsapertyratlindspvlsytdlvgfsYQVANGMDFLASKNCVHRDLAARNVLICEGK 838
Cdd:cd14007    96 ---RFDEKEAAKYI-----------------------------------YQLALALDYLHSKNIIHRDIKPENILLGSNG 137
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  839 LVKICDFGLardimrdSNYI--SKGSTFL-PLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYpELPMNDQFYN 915
Cdd:cd14007   138 ELKLADFGW-------SVHApsNRRKTFCgTLDYLPPEMVEGKEYDYKVDIWSLGVLCYELLV-GKPPF-ESKSHQETYK 208
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  916 AIKRG-YRMaqPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14007   209 RIQNVdIKF--PSSVSPEAKDLISKLLQKDPSKRLSLEQ 245
STKc_CAMK cd05117
The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of ...
601-903 8.67e-21

The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. CAMKIV is implicated in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors, as well as in T-cell development and signaling. The CAMK family also consists of other related kinases including the Phosphorylase kinase Gamma subunit (PhKG), the C-terminal kinase domains of Ribosomal S6 kinase (RSK) and Mitogen and stress-activated kinase (MSK), Doublecortin-like kinase (DCKL), and the MAPK-activated protein kinases MK2, MK3, and MK5, among others. The CAMK family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270687 [Multi-domain]  Cd Length: 258  Bit Score: 93.31  E-value: 8.67e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  601 VLGRTLGSGAFGQVVEATahglsHSQATMKVAVKML-KSTARSSEKQALMSELKIMSHLGpHLNVVNLLGA-CTKGGpIY 678
Cdd:cd05117     3 ELGKVLGRGSFGVVRLAV-----HKKTGEEYAVKIIdKKKLKSEDEEMLRREIEILKRLD-HPNIVKLYEVfEDDKN-LY 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  679 IITEYCRYGDLVDYLHRNKHtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdMSKDESIDYVpmldmk 758
Cdd:cd05117    76 LVMELCTGGELFDRIVKKGS--------------------------------------------FSEREAAKIM------ 105
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  759 gdikyadiespsymapydnyvpsapertyratlindspvlsytdlvgfsYQVANGMDFLASKNCVHRDLAARNVLIC--- 835
Cdd:cd05117   106 -------------------------------------------------KQILSAVAYLHSQGIVHRDLKPENILLAskd 136
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  836 EGKLVKICDFGLARdIMRDSNYISK--GStflpLKWMAPESIFNSLYTTLSDVWSFGILLWeiFTLGGTP 903
Cdd:cd05117   137 PDSPIKIIDFGLAK-IFEEGEKLKTvcGT----PYYVAPEVLKGKGYGKKCDIWSLGVILY--ILLCGYP 199
STKc_PknB_like cd14014
Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs ...
602-950 3.37e-20

Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270916 [Multi-domain]  Cd Length: 260  Bit Score: 91.49  E-value: 3.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  602 LGRTLGSGAFGQVVEATAHGLSHsqatmKVAVKMLKSTARSSE--KQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYI 679
Cdd:cd14014     4 LVRLLGRGGMGEVYRARDTLLGR-----PVAIKVLRPELAEDEefRERFLREARALARLS-HPNIVRVYDVGEDDGRPYI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  680 ITEYCRYGDLVDYLHRNKhtflqrhsnkhcppsaelysnALPVgfslpshlnltgesdggymdmskDESIDYVpmldmkg 759
Cdd:cd14014    78 VMEYVEGGSLADLLRERG---------------------PLPP-----------------------REALRIL------- 106
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  760 dikyadiespsymapydnyvpsapertyratlindspvlsytdlvgfsYQVANGMDFLASKNCVHRDLAARNVLICEGKL 839
Cdd:cd14014   107 ------------------------------------------------AQIADALAAAHRAGIVHRDIKPANILLTEDGR 138
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  840 VKICDFGLARdiMRDSNYISKGSTFL--PLkWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAI 917
Cdd:cd14014   139 VKLTDFGIAR--ALGDSGLTQTGSVLgtPA-YMAPEQARGGPVDPRSDIYSLGVVLYELLT-GRPPFDGDSPAAVLAKHL 214
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 226342982  918 KRGYRM--AQPAHASDEIYEIMQKCWEEKFETRPP 950
Cdd:cd14014   215 QEAPPPpsPLNPDVPPALDAIILRALAKDPEERPQ 249
Pkinase pfam00069
Protein kinase domain;
600-953 7.92e-20

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 89.23  E-value: 7.92e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   600 LVLGRTLGSGAFGQVVEATahglsHSQATMKVAVKML-KSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIY 678
Cdd:pfam00069    1 YEVLRKLGSGSFGTVYKAK-----HRDTGKIVAIKKIkKEKIKKKKDKNILREIKILKKLN-HPNIVRLYDAFEDKDNLY 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   679 IITEYCRYGDLVDYLHRNKHtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdMSKDESIDYVPMLdMK 758
Cdd:pfam00069   75 LVLEYVEGGSLFDLLSEKGA--------------------------------------------FSEREAKFIMKQI-LE 109
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   759 GdikyadIESPSymapydnyvpsapertyratlindspvlSYTDLVGFSYqvangmdflaskncvhrdlaarnvlicegk 838
Cdd:pfam00069  110 G------LESGS----------------------------SLTTFVGTPW------------------------------ 125
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   839 lvkicdfglardimrdsnyiskgstflplkWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIK 918
Cdd:pfam00069  126 ------------------------------YMAPEVLGGNPYGPKVDVWSLGCILYELLT-GKPPFPGINGNEIYELIID 174
                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 226342982   919 RGYRMAQ-PAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:pfam00069  175 QPYAFPElPSNLSEEAKDLLKKLLKKDPSKRLTATQ 210
STKc_C-Raf cd14149
Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) ...
593-953 9.53e-20

Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. C-Raf, also known as Raf-1 or c-Raf-1, is ubiquitously expressed and was the first Raf identified. It was characterized as the acquired oncogene from an acutely transforming murine sarcoma virus (3611-MSV) and the transforming agent from the avian retrovirus MH2. C-Raf-deficient mice embryos die around midgestation with increased apoptosis of embryonic tissues, especially in the fetal liver. One of the main functions of C-Raf is restricting caspase activation to promote survival in response to specific stimuli such as Fas stimulation, macrophage apoptosis, and erythroid differentiation. C-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The C-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271051 [Multi-domain]  Cd Length: 283  Bit Score: 90.86  E-value: 9.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVLGRTLGSGAFGQVVEATAHGlshsqatmKVAVKMLKSTARSSEK-QALMSELKIMSHLgPHLNVVNLLGAC 671
Cdd:cd14149     7 WEIEASEVMLSTRIGSGSFGTVYKGKWHG--------DVAVKILKVVDPTPEQfQAFRNEVAVLRKT-RHVNILLFMGYM 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  672 TKGGpIYIITEYCRYGDLVDYLHrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidy 751
Cdd:cd14149    78 TKDN-LAIVTQWCEGSSLYKHLH--------------------------------------------------------- 99
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  752 vpMLDMKgdikyadiespsymapydnyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARN 831
Cdd:cd14149   100 --VQETK---------------------------------------FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNN 138
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  832 VLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIF---NSLYTTLSDVWSFGILLWEIFTlGGTPYPELP 908
Cdd:cd14149   139 IFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRmqdNNPFSFQSDVYSYGIVLYELMT-GELPYSHIN 217
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 226342982  909 MNDQFYNAIKRGYRMAQPAHASDEIYEIMQK----CWEEKFETRPPFSQ 953
Cdd:cd14149   218 NRDQIIFMVGRGYASPDLSKLYKNCPKAMKRlvadCIKKVKEERPLFPQ 266
STKc_MEKK1_plant cd06632
Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP) ...
603-953 1.17e-19

Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of plant MAPK kinase kinases (MAPKKKs) including Arabidopsis thaliana MEKK1 and MAPKKK3. Arabidopsis thaliana MEKK1 activates MPK4, a MAPK that regulates systemic acquired resistance. MEKK1 also participates in the regulation of temperature-sensitive and tissue-specific cell death. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The plant MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270802 [Multi-domain]  Cd Length: 259  Bit Score: 89.77  E-value: 1.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  603 GRTLGSGAFGQVVEatahGLSHSQATMkVAVKMLK-----STARSSEKQaLMSELKIMSHLgPHLNVVNLLGACTKGGPI 677
Cdd:cd06632     5 GQLLGSGSFGSVYE----GFNGDTGDF-FAVKEVSlvdddKKSRESVKQ-LEQEIALLSKL-RHPNIVQYYGTEREEDNL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  678 YIITEYCRYGDLVDYLHRnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldm 757
Cdd:cd06632    78 YIFLEYVPGGSIHKLLQR-------------------------------------------------------------- 95
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  758 kgdikYADIESPSymapydnyvpsapertyratlindspVLSYTDlvgfsyQVANGMDFLASKNCVHRDLAARNVLICEG 837
Cdd:cd06632    96 -----YGAFEEPV--------------------------IRLYTR------QILSGLAYLHSRNTVHRDIKGANILVDTN 138
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  838 KLVKICDFGLARDIMRDSNYIS-KGSTFlplkWMAPESI--FNSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFY 914
Cdd:cd06632   139 GVVKLADFGMAKHVEAFSFAKSfKGSPY----WMAPEVImqKNSGYGLAVDIWSLGCTVLEMAT-GKPPWSQYEGVAAIF 213
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 226342982  915 NAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd06632   214 KIGNSGELPPIPDHLSPDAKDFIRLCLQRDPEDRPTASQ 252
PKc_LIMK_like cd14065
Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of ...
606-953 1.34e-19

Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. Members of this subfamily include LIMK, Testicular or testis-specific protein kinase (TESK), and similar proteins. LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270967 [Multi-domain]  Cd Length: 252  Bit Score: 89.47  E-value: 1.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATahglsHSQATMKVAVKMLKstaRSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITEYCR 685
Cdd:cd14065     1 LGKGFFGEVYKVT-----HRETGKVMVMKELK---RFDEQRSFLKEVKLMRRLS-HPNILRFIGVCVKDNKLNFITEYVN 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  686 YGDLVDYLhrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdMSKDESIDYvpmldmkgdikyad 765
Cdd:cd14065    72 GGTLEELL-------------------------------------------------KSMDEQLPW-------------- 88
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  766 iespsymapydnyvpsaPERTYratlindspvlsytdlvgFSYQVANGMDFLASKNCVHRDLAARNVLICE---GKLVKI 842
Cdd:cd14065    89 -----------------SQRVS------------------LAKDIASGMAYLHSKNIIHRDLNSKNCLVREanrGRNAVV 133
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  843 CDFGLARDIM--------RDSNYISKGSTFlplkWMAPESIFNSLYTTLSDVWSFGILLWEIftLGGTPY-PE-LPMNDQ 912
Cdd:cd14065   134 ADFGLAREMPdektkkpdRKKRLTVVGSPY----WMAPEMLRGESYDEKVDVFSFGIVLCEI--IGRVPAdPDyLPRTMD 207
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 226342982  913 FYNAIkRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14065   208 FGLDV-RAFRTLYVPDCPPSFLPLAIRCCQLDPEKRPSFVE 247
STKc_Nek cd08215
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; ...
604-940 3.29e-19

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek family is composed of 11 different mammalian members (Nek1-11) with similarity to the catalytic domain of Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants that were prevented from entering mitosis. Neks contain a conserved N-terminal catalytic domain and a more divergent C-terminal regulatory region of various sizes and structures. They are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270855 [Multi-domain]  Cd Length: 258  Bit Score: 88.67  E-value: 3.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEATaHGLSHSQATMKVaVKMLKSTARssEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITEY 683
Cdd:cd08215     6 RVIGKGSFGSAYLVR-RKSDGKLYVLKE-IDLSNMSEK--EREEALNEVKLLSKLK-HPNIVKYYESFEENGKLCIVMEY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  684 CRYGDLVDYLHRnkhtflQRHSNKHcppsaelysnalpvgFslpshlnltgesdggymdmskdesidyvpmldmkgdiky 763
Cdd:cd08215    81 ADGGDLAQKIKK------QKKKGQP---------------F--------------------------------------- 100
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  764 adiespsymapydnyvpsaPERTyratlindspVLSYtdlvgFSyQVANGMDFLASKNCVHRDLAARNVLICEGKLVKIC 843
Cdd:cd08215   101 -------------------PEEQ----------ILDW-----FV-QICLALKYLHSRKILHRDLKTQNIFLTKDGVVKLG 145
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  844 DFGLARdIMRDSNyiSKGSTFL--PLkWMAPESIFNSLYTTLSDVWSFGILLWEIFTL----GGTPYPELpmndqfYNAI 917
Cdd:cd08215   146 DFGISK-VLESTT--DLAKTVVgtPY-YLSPELCENKPYNYKSDIWALGCVLYELCTLkhpfEANNLPAL------VYKI 215
                         330       340
                  ....*....|....*....|...
gi 226342982  918 KRGYRMAQPAHASDEIYEIMQKC 940
Cdd:cd08215   216 VKGQYPPIPSQYSSELRDLVNSM 238
STKc_RIP1 cd14027
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze ...
806-953 5.10e-19

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP1 harbors a C-terminal Death domain (DD), which binds death receptors (DRs) including TNF receptor 1, Fas, TNF-related apoptosis-inducing ligand receptor 1 (TRAILR1), and TRAILR2. It also interacts with other DD-containing adaptor proteins such as TRADD and FADD. RIP1 can also recruit other kinases including MEKK1, MEKK3, and RIP3 through an intermediate domain (ID) that bears a RIP homotypic interaction motif (RHIM). RIP1 plays a crucial role in determining a cell's fate, between survival or death, following exposure to stress signals. It is important in the signaling of NF-kappaB and MAPKs, and it links DR-associated signaling to reactive oxygen species (ROS) production. Abnormal RIP1 function may result in ROS accummulation affecting inflammatory responses, innate immunity, stress responses, and cell survival. RIP kinases serve as essential sensors of cellular stress. The RIP1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270929 [Multi-domain]  Cd Length: 267  Bit Score: 88.33  E-value: 5.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLA--------------RDIMRDSNYISKGSTflpLKWMA 871
Cdd:cd14027    95 IILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLAsfkmwskltkeehnEQREVDGTAKKNAGT---LYYMA 171
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  872 PESI--FNSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRMAQ---PAHASDEIYEIMQKCWEEKFE 946
Cdd:cd14027   172 PEHLndVNAKPTEKSDVYSFAIVLWAIFA-NKEPYENAINEDQIIMCIKSGNRPDVddiTEYCPREIIDLMKLCWEANPE 250

                  ....*..
gi 226342982  947 TRPPFSQ 953
Cdd:cd14027   251 ARPTFPG 257
STKc_Byr2_like cd06628
Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein ...
778-953 2.05e-18

Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Schizosaccharomyces pombe Byr2, Saccharomyces cerevisiae and Cryptococcus neoformans Ste11, and related proteins. They contain an N-terminal SAM (sterile alpha-motif) domain, which mediates protein-protein interaction, and a C-terminal catalytic domain. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Byr2 is regulated by Ras1. It responds to pheromone signaling and controls mating through the MAPK pathway. Budding yeast Ste11 functions in MAPK cascades that regulate mating, high osmolarity glycerol, and filamentous growth responses. The Byr2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270798 [Multi-domain]  Cd Length: 267  Bit Score: 86.43  E-value: 2.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  778 YVPSAPErtyrATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNY 857
Cdd:cd06628    87 YVPGGSV----ATLLNNYGAFEESLVRNFVRQILKGLNYLHNRGIIHRDIKGANILVDNKGGIKISDFGISKKLEANSLS 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  858 IS--------KGSTFlplkWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELpmnDQFYNAIKRG--YRMAQPA 927
Cdd:cd06628   163 TKnngarpslQGSVF----WMAPEVVKQTSYTRKADIWSLGCLVVEMLT-GTHPFPDC---TQMQAIFKIGenASPTIPS 234
                         170       180
                  ....*....|....*....|....*.
gi 226342982  928 HASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd06628   235 NISSEARDFLEKTFEIDHNKRPTADE 260
PKc_MAPKK_plant_like cd06623
Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and ...
598-949 1.14e-17

Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include MAPKKs from plants, kinetoplastids, alveolates, and mycetozoa. The MAPKK, LmxPK4, from Leishmania mexicana, is important in differentiation and virulence. Dictyostelium discoideum MEK1 is required for proper chemotaxis; MEK1 null mutants display severe defects in cell polarization and directional movement. Plants contain multiple MAPKKs like other eukaryotes. The Arabidopsis genome encodes for 10 MAPKKs while poplar and rice contain 13 MAPKKs each. The functions of these proteins have not been fully elucidated. There is evidence to suggest that MAPK cascades are involved in plant stress responses. In Arabidopsis, MKK3 plays a role in pathogen signaling; MKK2 is involved in cold and salt stress signaling; MKK4/MKK5 participates in innate immunity; and MKK7 regulates basal and systemic acquired resistance. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132954 [Multi-domain]  Cd Length: 264  Bit Score: 84.18  E-value: 1.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  598 DQLVLGRTLGSGAFGQVVEATaHGLSHSQatmkVAVKMLKSTARSSEKQALMSELKIMsHLGPHLNVVNLLGACTKGGPI 677
Cdd:cd06623     1 SDLERVKVLGQGSSGVVYKVR-HKPTGKI----YALKKIHVDGDEEFRKQLLRELKTL-RSCESPYVVKCYGAFYKEGEI 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  678 YIITEYcrygdlvdylhrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggyMDM-SKDESIDYVPMLd 756
Cdd:cd06623    75 SIVLEY---------------------------------------------------------MDGgSLADLLKKVGKI- 96
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  757 mkgdikyadiespsymapydnyvpsaPErtyratlindsPVLSYtdlvgFSYQVANGMDFL-ASKNCVHRDLAARNVLIC 835
Cdd:cd06623    97 --------------------------PE-----------PVLAY-----IARQILKGLDYLhTKRHIIHRDIKPSNLLIN 134
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  836 EGKLVKICDFGLARDImrdSNYISKGSTFL-PLKWMAPESIFNSLYTTLSDVWSFGILLWEiFTLGGTPYPELPMNDQF- 913
Cdd:cd06623   135 SKGEVKIADFGISKVL---ENTLDQCNTFVgTVTYMSPERIQGESYSYAADIWSLGLTLLE-CALGKFPFLPPGQPSFFe 210
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 226342982  914 -YNAIKRGYRMAQPA-HASDEIYEIMQKCWEEKFETRP 949
Cdd:cd06623   211 lMQAICDGPPPSLPAeEFSPEFRDFISACLQKDPKKRP 248
STKc_MST3_like cd06609
Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs ...
808-909 3.15e-17

Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST3, MST4, STK25, Schizosaccharomyces pombe Nak1 and Sid1, Saccharomyces cerevisiae sporulation-specific protein 1 (SPS1), and related proteins. Nak1 is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Sid1 is a component in the septation initiation network (SIN) signaling pathway, and plays a role in cytokinesis. SPS1 plays a role in regulating proteins required for spore wall formation. MST4 plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. STK25 may play a role in the regulation of cell migration and polarization. The MST3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270786 [Multi-domain]  Cd Length: 274  Bit Score: 83.06  E-value: 3.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrdSNYISKGSTFL--PLkWMAPESIFNSLYTTLSD 885
Cdd:cd06609   105 REVLLGLEYLHSEGKIHRDIKAANILLSEEGDVKLADFGVSGQL---TSTMSKRNTFVgtPF-WMAPEVIKQSGYDEKAD 180
                          90       100
                  ....*....|....*....|....*
gi 226342982  886 VWSFGILLWEIFTlGGTPYPEL-PM 909
Cdd:cd06609   181 IWSLGITAIELAK-GEPPLSDLhPM 204
PTKc_Aatyk2 cd05086
Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2; PTKs ...
606-941 4.47e-17

Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Aatyk2 is a member of the Aatyk subfamily of proteins, which are receptor kinases containing a transmembrane segment and a long C-terminal cytoplasmic tail with a catalytic domain. Aatyk2 is also called lemur tyrosine kinase 2 (Lmtk2) or brain-enriched kinase (Brek). It is expressed at high levels in early postnatal brain, and has been shown to play a role in nerve growth factor (NGF) signaling. Studies with knockout mice reveal that Aatyk2 is essential for late stage spermatogenesis. Although it is classified as a PTK based on sequence similarity and the phylogenetic tree, Aatyk2 has been functionally characterized as a serine/threonine kinase. The Aatyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270669 [Multi-domain]  Cd Length: 271  Bit Score: 82.61  E-value: 4.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATahgLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACTKGGPIYIITEYCR 685
Cdd:cd05086     5 IGNGWFGKVLLGE---IYTGTSVARVVVKELKASANPKEQDDFLQQGEPYYIL-QHPNILQCVGQCVEAIPYLLVFEFCD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  686 YGDLVDYLhrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdMSKDESidyvpmldMKGDikyAD 765
Cdd:cd05086    81 LGDLKTYL-------------------------------------------------ANQQEK--------LRGD---SQ 100
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  766 IESPSYMApydnyvpsapertyratlindspvlsytdlvgfsYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDF 845
Cdd:cd05086   101 IMLLQRMA----------------------------------CEIAAGLAHMHKHNFLHSDLALRNCYLTSDLTVKVGDY 146
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  846 GLARDIMRDSNYISKGSTFLPLKWMAPE-------SIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIK 918
Cdd:cd05086   147 GIGFSRYKEDYIETDDKKYAPLRWTAPElvtsfqdGLLAAEQTKYSNIWSLGVTLWELFENAAQPYSDLSDREVLNHVIK 226
                         330       340
                  ....*....|....*....|....*..
gi 226342982  919 -RGYRMAQPAHA---SDEIYEIMQKCW 941
Cdd:cd05086   227 eRQVKLFKPHLEqpySDRWYEVLQFCW 253
STKc_Mos cd13979
Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze ...
598-949 1.11e-16

Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mos (or c-Mos) is a germ-cell specific kinase that plays roles in both the release of primary arrest and the induction of secondary arrest in oocytes. It is expressed towards the end of meiosis I and is quickly degraded upon fertilization. It is a component of the cytostatic factor (CSF), which is responsible for metaphase II arrest. In addition, Mos activates a phoshorylation cascade that leads to the activation of the p34 subunit of MPF (mitosis-promoting factor or maturation promoting factor), a cyclin-dependent kinase that is responsible for the release of primary arrest in meiosis I. The Mos subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270881 [Multi-domain]  Cd Length: 265  Bit Score: 81.28  E-value: 1.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  598 DQLVLGRTLGSGAFGQVVEATAHGLShsqatmkVAVKMLK-STARSSEKQALMSELKImSHLgPHLNVVNLLGA---CTK 673
Cdd:cd13979     3 EPLRLQEPLGSGGFGSVYKATYKGET-------VAVKIVRrRRKNRASRQSFWAELNA-ARL-RHENIVRVLAAetgTDF 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  674 GGPIYIITEYCRYGDLVDYLhrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesDGGYMDMSKDESIDYvp 753
Cdd:cd13979    74 ASLGLIIMEYCGNGTLQQLI-------------------------------------------YEGSEPLPLAHRILI-- 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  754 mldmkgdikyadiespsymapydnyvpsapertyratlindspvlsytdlvgfSYQVANGMDFLASKNCVHRDLAARNVL 833
Cdd:cd13979   109 -----------------------------------------------------SLDIARALRFCHSHGIVHLDVKPANIL 135
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  834 ICEGKLVKICDFGLARdIMRDSNYISKGSTFL--PLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELpmnD 911
Cdd:cd13979   136 ISEQGVCKLCDFGCSV-KLGEGNEVGTPRSHIggTYTYRAPELLKGERVTPKADIYSFGITLWQMLT-RELPYAGL---R 210
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 226342982  912 QF--YNAIKRGYRMAQPAHASDEIYE----IMQKCWEEKFETRP 949
Cdd:cd13979   211 QHvlYAVVAKDLRPDLSGLEDSEFGQrlrsLISRCWSAQPAERP 254
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
601-905 1.30e-16

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 84.29  E-value: 1.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  601 VLGRTLGSGAFGQVVEATAHGLSHsqatmKVAVKMLKSTARSSEK--QALMSELKIMSHLGpHLNVVNLLGACTKGGPIY 678
Cdd:COG0515    10 RILRLLGRGGMGVVYLARDLRLGR-----PVALKVLRPELAADPEarERFRREARALARLN-HPNIVRVYDVGEEDGRPY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  679 IITEYCRYGDLVDYLHRNKhtflqrhsnkhcppsaelysnALPVgfslpshlnltgesdggymdmskDESIDYVpmldmk 758
Cdd:COG0515    84 LVMEYVEGESLADLLRRRG---------------------PLPP-----------------------AEALRIL------ 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  759 gdikyadiespsymapydnyvpsapertyratlindspvlsytdlvgfsYQVANGMDFLASKNCVHRDLAARNVLICEGK 838
Cdd:COG0515   114 -------------------------------------------------AQLAEALAAAHAAGIVHRDIKPANILLTPDG 144
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226342982  839 LVKICDFGLARdIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYP 905
Cdd:COG0515   145 RVKLIDFGIAR-ALGGATLTQTGTVVGTPGYMAPEQARGEPVDPRSDVYSLGVTLYELLT-GRPPFD 209
STKc_MST1_2 cd06612
Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; ...
808-949 1.35e-16

Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST1, MST2, and related proteins including Drosophila Hippo and Dictyostelium discoideum Krs1 (kinase responsive to stress 1). MST1/2 and Hippo are involved in a conserved pathway that governs cell contact inhibition, organ size control, and tumor development. MST1 activates the mitogen-activated protein kinases (MAPKs) p38 and c-Jun N-terminal kinase (JNK) through MKK7 and MEKK1 by acting as a MAPK kinase kinase kinase. Activation of JNK by MST1 leads to caspase activation and apoptosis. MST1 has also been implicated in cell proliferation and differentiation. Krs1 may regulate cell growth arrest and apoptosis in response to cellular stress. The MST1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132943 [Multi-domain]  Cd Length: 256  Bit Score: 80.77  E-value: 1.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLA---RDIMRDSN-YIskGSTFlplkWMAPESIFNSLYTTL 883
Cdd:cd06612   106 YQTLKGLEYLHSNKKIHRDIKAGNILLNEEGQAKLADFGVSgqlTDTMAKRNtVI--GTPF----WMAPEVIQEIGYNNK 179
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226342982  884 SDVWSFGILLWEIFTlGGTPYPEL-PMNDQFynAIKRG--YRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd06612   180 ADIWSLGITAIEMAE-GKPPYSDIhPMRAIF--MIPNKppPTLSDPEKWSPEFNDFVKKCLVKDPEERP 245
STKc_myosinIII_N_like cd06608
N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze ...
596-949 1.86e-16

N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class III myosins are motor proteins with an N-terminal kinase catalytic domain and a C-terminal actin-binding motor domain. Class III myosins are present in the photoreceptors of invertebrates and vertebrates and in the auditory hair cells of mammals. The kinase domain of myosin III can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, and can autophosphorylate the C-terminal motor domain. Myosin III may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. It may also function as a cargo carrier during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The Drosophila class III myosin, called NinaC (Neither inactivation nor afterpotential protein C), is critical in normal adaptation and termination of photoresponse. Vertebrates contain two isoforms of class III myosin, IIIA and IIIB. This subfamily also includes mammalian NIK-like embryo-specific kinase (NESK), Traf2- and Nck-interacting kinase (TNIK), and mitogen-activated protein kinase (MAPK) kinase kinase kinase 4/6. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The class III myosin-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270785 [Multi-domain]  Cd Length: 275  Bit Score: 80.81  E-value: 1.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  596 PRDQLVLGRTLGSGAFGQVVEATahglsHSQATMKVAVKMLKSTArsSEKQALMSELKIMSHLGPHLNVVNLLGACTKGG 675
Cdd:cd06608     4 PAGIFELVEVIGEGTYGKVYKAR-----HKKTGQLAAIKIMDIIE--DEEEEIKLEINILRKFSNHPNIATFYGAFIKKD 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  676 P------IYIITEYCRYGDLVDylhrnkhtflqrhsnkhcppsaeLYSNALPVGFSLPSHLnltgesdggymdmskdesi 749
Cdd:cd06608    77 PpggddqLWLVMEYCGGGSVTD-----------------------LVKGLRKKGKRLKEEW------------------- 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  750 dyvpmldmkgdIKYadiespsymapydnyvpsapertyratlindspvlsytdlvgFSYQVANGMDFLASKNCVHRDLAA 829
Cdd:cd06608   115 -----------IAY------------------------------------------ILRETLRGLAYLHENKVIHRDIKG 141
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  830 RNVLICEGKLVKICDFGLARD----IMRDSNYIskGSTFlplkWMAPESI-----FNSLYTTLSDVWSFGILLWEIFTlG 900
Cdd:cd06608   142 QNILLTEEAEVKLVDFGVSAQldstLGRRNTFI--GTPY----WMAPEVIacdqqPDASYDARCDVWSLGITAIELAD-G 214
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 226342982  901 GTPYPEL-PMNDQFynAIKRGY--RMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd06608   215 KPPLCDMhPMRALF--KIPRNPppTLKSPEKWSKEFNDFISECLIKNYEQRP 264
PK_KSR cd14063
Pseudokinase domain of Kinase Suppressor of Ras; The pseudokinase domain shows similarity to ...
599-953 2.02e-16

Pseudokinase domain of Kinase Suppressor of Ras; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. The KSR subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270965 [Multi-domain]  Cd Length: 271  Bit Score: 80.86  E-value: 2.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  599 QLVLGRTLGSGAFGQVVEATAHGlshsqatmKVAVKMLKSTARSSE-----KQALMSELKIMshlgpHLNVVNLLGACTK 673
Cdd:cd14063     1 ELEIKEVIGKGRFGRVHRGRWHG--------DVAIKLLNIDYLNEEqleafKEEVAAYKNTR-----HDNLVLFMGACMD 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  674 GGPIYIITEYCRYGDLVDYLHRNKHTFlqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymDMSKdesidyvp 753
Cdd:cd14063    68 PPHLAIVTSLCKGRTLYSLIHERKEKF-----------------------------------------DFNK-------- 98
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  754 mldmkgdikyadiespsymapydnyvpsapertyratlindspvlsytdLVGFSYQVANGMDFLASKNCVHRDLAARNVL 833
Cdd:cd14063    99 -------------------------------------------------TVQIAQQICQGMGYLHAKGIIHKDLKSKNIF 129
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  834 ICEGKLVkICDFGLARdiMRDSNYISKGSTFL--PLKW---MAPESI---------FNSL-YTTLSDVWSFGILLWEIFT 898
Cdd:cd14063   130 LENGRVV-ITDFGLFS--LSGLLQPGRREDTLviPNGWlcyLAPEIIralspdldfEESLpFTKASDVYAFGTVWYELLA 206
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 226342982  899 lGGTPYPELPMNDQFYnAIKRGYRMAQPAHASD-EIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14063   207 -GRWPFKEQPAESIIW-QVGCGKKQSLSQLDIGrEVKDILMQCWAYDPEKRPTFSD 260
STKc_IRAK4 cd14158
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; ...
597-953 2.46e-16

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK4 plays a critical role in NFkB activation by its interaction with MyD88, which acts as a scaffold that enables IRAK4 to phosphorylate and activate IRAK1 and/or IRAK2. It also plays an important role in type I IFN production induced by TLR7/8/9. The IRAK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271060 [Multi-domain]  Cd Length: 288  Bit Score: 80.62  E-value: 2.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  597 RDQLVLGRTLGSGAFGQVVEATAHGLShsqatmkVAVKMLKSTARSS---EKQALMSELKIMSHLgPHLNVVNLLGaCTK 673
Cdd:cd14158    14 RPISVGGNKLGEGGFGVVFKGYINDKN-------VAVKKLAAMVDIStedLTKQFEQEIQVMAKC-QHENLVELLG-YSC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  674 GGPIY-IITEYCRYGDLVDylhrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyv 752
Cdd:cd14158    85 DGPQLcLVYTYMPNGSLLD------------------------------------------------------------- 103
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyadiespsymapydnyvpsapertyRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd14158   104 -----------------------------------RLACLNDTPPLSWHMRCKIAQGTANGINYLHENNHIHRDIKSANI 148
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLyTTLSDVWSFGILLWEIFTlGGTPYPE------ 906
Cdd:cd14158   149 LLDETFVPKISDFGLARASEKFSQTIMTERIVGTTAYMAPEALRGEI-TPKSDIFSFGVVLLEIIT-GLPPVDEnrdpql 226
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 226342982  907 -LPMNDQFYNAIKRGY-----RMAQ-PAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14158   227 lLDIKEEIEDEEKTIEdyvdkKMGDwDSTSIEAMYSVASQCLNDKKNRRPDIAK 280
STKc_CMGC cd05118
Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
604-898 5.24e-16

Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs), Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs), c-Jun N-terminal kinases (JNKs), and p38, and other kinases. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Other members of the CMGC family include casein kinase 2 (CK2), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK), Glycogen Synthase Kinase 3 (GSK3), among many others. The CMGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270688 [Multi-domain]  Cd Length: 249  Bit Score: 78.82  E-value: 5.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEAtaHGLSHSQatmKVAVKMLKstARSSEKQALMSELKIMSHLG---PHLNVVNLLGACT--KGGPIY 678
Cdd:cd05118     5 RKIGEGAFGTVWLA--RDKVTGE---KVAIKKIK--NDFRHPKAALREIKLLKHLNdveGHPNIVKLLDVFEhrGGNHLC 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  679 IITEYCRYgDLVDYLHRNKhtflQRHSNKHcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmk 758
Cdd:cd05118    78 LVFELMGM-NLYELIKDYP----RGLPLDL-------------------------------------------------- 102
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  759 gdIKYadiespsymapydnyvpsapertyratlindspvlsytdlvgFSYQVANGMDFLASKNCVHRDLAARNVLICEGK 838
Cdd:cd05118   103 --IKS------------------------------------------YLYQLLQALDFLHSNGIIHRDLKPENILINLEL 138
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  839 -LVKICDFGLARdIMRDSNYISKGSTflpLKWMAPESIFNSL-YTTLSDVWSFGILLWEIFT 898
Cdd:cd05118   139 gQLKLADFGLAR-SFTSPPYTPYVAT---RWYRAPEVLLGAKpYGSSIDIWSLGCILAELLT 196
STKc_IRAK cd14066
Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases ...
606-915 5.27e-16

Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. Some IRAKs may also play roles in T- and B-cell signaling, and adaptive immunity. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK-1, -2, and -4 are ubiquitously expressed and are active kinases, while IRAK-M is only induced in monocytes and macrophages and is an inactive kinase. Variations in IRAK genes are linked to diverse diseases including infection, sepsis, cancer, and autoimmune diseases. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain (a pseudokinase domain in the case of IRAK3), and a C-terminal domain; IRAK-4 lacks the C-terminal domain. This subfamily includes plant receptor-like kinases (RLKs) including Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1). BAK1 functions in BR (brassinosteroid)-regulated plant development and in pathways involved in plant resistance to pathogen infection and herbivore attack. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The IRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270968 [Multi-domain]  Cd Length: 272  Bit Score: 79.62  E-value: 5.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATAHGLSHsqatmkVAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACTKGGPIYIITEYCR 685
Cdd:cd14066     1 IGSGGFGTVYKGVLENGTV------VAVKRLNEMNCAASKKEFLTELEMLGRL-RHPNLVRLLGYCLESDEKLLVYEYMP 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  686 YGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgdikyad 765
Cdd:cd14066    74 NGSLEDRLHCHK-------------------------------------------------------------------- 85
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  766 iespsymapydnyvpsapertyratlinDSPVLSYTDLVGFSYQVANGMDFL---ASKNCVHRDLAARNVLICEGKLVKI 842
Cdd:cd14066    86 ----------------------------GSPPLPWPQRLKIAKGIARGLEYLheeCPPPIIHGDIKSSNILLDEDFEPKL 137
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982  843 CDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYN 915
Cdd:cd14066   138 TDFGLARLIPPSESVSKTSAVKGTIGYLAPEYIRTGRVSTKSDVYSFGVVLLELLT-GKPAVDENRENASRKD 209
STKc_LIMK cd14154
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer ...
778-953 5.71e-16

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. Vertebrate have two members, LIMK1 and LIMK2. The LIMK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271056 [Multi-domain]  Cd Length: 272  Bit Score: 79.47  E-value: 5.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  778 YVPSAperTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRD--- 854
Cdd:cd14154    71 YIPGG---TLKDVLKDMARPLPWAQRVRFAKDIASGMAYLHSMNIIHRDLNSHNCLVREDKTVVVADFGLARLIVEErlp 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  855 SNYISKGSTFLPLK---------------WMAPESIFNSLYTTLSDVWSFGILLWEIFtlgGTPYPE---LPMNDQFyNA 916
Cdd:cd14154   148 SGNMSPSETLRHLKspdrkkrytvvgnpyWMAPEMLNGRSYDEKVDIFSFGIVLCEII---GRVEADpdyLPRTKDF-GL 223
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 226342982  917 IKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14154   224 NVDSFREKFCAGCPPPFFKLAFLCCDLDPEKRPPFET 260
STKc_Nek2 cd08217
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
824-949 1.69e-15

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek2 subfamily includes Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants prevented from entering mitosis. NIMA is essential for mitotic entry and progression through mitosis, and its degradation is essential for mitotic exit. NIMA is involved in nuclear membrane fission. Vertebrate Nek2 is a cell cycle-regulated STK, localized in centrosomes and kinetochores, that regulates centrosome splitting at the G2/M phase. It also interacts with other mitotic kinases such as Polo-like kinase 1 and may play a role in spindle checkpoint. An increase in the expression of the human NEK2 gene is strongly associated with the progression of non-Hodgkin lymphoma. Nek2 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. It The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270857 [Multi-domain]  Cd Length: 265  Bit Score: 77.97  E-value: 1.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  824 HRDLAARNVLICEGKLVKICDFGLARDIMRDSNYiskGSTFL--PLkWMAPESIFNSLYTTLSDVWSFGILLWEIFTLG- 900
Cdd:cd08217   133 HRDLKPANIFLDSDNNVKLGDFGLARVLSHDSSF---AKTYVgtPY-YMSPELLNEQSYDEKSDIWSLGCLIYELCALHp 208
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 226342982  901 ---GTPYPELPMNdqfynaIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd08217   209 pfqAANQLELAKK------IKEGKFPRIPSRYSSELNEVIKSMLNVDPDKRP 254
PK_GC cd13992
Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows ...
806-953 1.74e-15

Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs lack a critical aspartate involved in ATP binding and does not exhibit kinase activity. It functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270894 [Multi-domain]  Cd Length: 268  Bit Score: 77.82  E-value: 1.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFL-ASKNCVHRDLAARNVLICEGKLVKICDFGLARdIMRDSNYISKGSTFLPLK--WMAPESIFNSLYTT 882
Cdd:cd13992   102 FIKDIVKGMNYLhSSSIGYHGRLKSSNCLVDSRWVVKLTDFGLRN-LLEEQTNHQLDEDAQHKKllWTAPELLRGSLLEV 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  883 L----SDVWSFGILLWEIFTLGGtPYPELPMNDQFYNAIKRGYRMAQP--AHASDE----IYEIMQKCWEEKFETRPPFS 952
Cdd:cd13992   181 RgtqkGDVYSFAIILYEILFRSD-PFALEREVAIVEKVISGGNKPFRPelAVLLDEfpprLVLLVKQCWAENPEKRPSFK 259

                  .
gi 226342982  953 Q 953
Cdd:cd13992   260 Q 260
STKc_LIMK1 cd14221
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the ...
804-953 1.84e-15

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK1 activation is induced by bone morphogenic protein, vascular endothelial growth factor, and thrombin. It plays roles in microtubule disassembly and cell cycle progression, and is critical in the regulation of neurite outgrowth. LIMK1 knockout mice show abnormalities in dendritic spine morphology and synaptic function. LIMK1 is one of the genes deleted in patients with Williams Syndrome, which is characterized by distinct craniofacial features, cardiovascular problems, as well as behavioral and neurological abnormalities. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271123 [Multi-domain]  Cd Length: 267  Bit Score: 77.69  E-value: 1.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  804 VGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSN----------------YISKGSTFlpl 867
Cdd:cd14221    94 VSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKSVVVADFGLARLMVDEKTqpeglrslkkpdrkkrYTVVGNPY--- 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  868 kWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFET 947
Cdd:cd14221   171 -WMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPIAVLCCDLDPEK 249

                  ....*.
gi 226342982  948 RPPFSQ 953
Cdd:cd14221   250 RPSFSK 255
STKc_TSSK-like cd14080
Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs ...
602-893 2.23e-15

Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. TSSK6, also called SSTK, is expressed at the head of elongated sperm. TSSK1/TSSK2 double knock-out and TSSK6 null mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270982 [Multi-domain]  Cd Length: 262  Bit Score: 77.22  E-value: 2.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  602 LGRTLGSGAFGQVVEATAHGLSHSQatmKVAVKMLkSTARSSE---KQALMSELKIMSHLGpHLNVVNLLGACTKGGPIY 678
Cdd:cd14080     4 LGKTIGEGSYSKVKLAEYTKSGLKE---KVACKII-DKKKAPKdflEKFLPRELEILRKLR-HPNIIQVYSIFERGSKVF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  679 IITEYCRYGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmk 758
Cdd:cd14080    79 IFMEYAEHGDLLEYIQKRG------------------------------------------------------------- 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  759 gdikyadiespsymapydnyvpSAPERTYRAtlindspvlsytdlvgFSYQVANGMDFLASKNCVHRDLAARNVLICEGK 838
Cdd:cd14080    98 ----------------------ALSESQARI----------------WFRQLALAVQYLHSLDIAHRDLKCENILLDSNN 139
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  839 LVKICDFGLARDIMRDSNYI-SK---GSTFlplkWMAPESIFNSLYT-TLSDVWSFGILL 893
Cdd:cd14080   140 NVKLSDFGFARLCPDDDGDVlSKtfcGSAA----YAAPEILQGIPYDpKKYDIWSLGVIL 195
PKc_Dusty cd13975
Catalytic domain of the Dual-specificity Protein Kinase, Dusty; Dual-specificity PKs catalyze ...
810-949 8.38e-15

Catalytic domain of the Dual-specificity Protein Kinase, Dusty; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Dusty protein kinase is also called Receptor-interacting protein kinase 5 (RIPK5 or RIP5) or RIP-homologous kinase. It is widely distributed in the central nervous system, and may be involved in inducing both caspase-dependent and caspase-independent cell death. The Dusty subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270877 [Multi-domain]  Cd Length: 262  Bit Score: 75.60  E-value: 8.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLAR-DIMrdsnyISKGSTFLPLKwMAPEsIFNSLYTTLSDVWS 888
Cdd:cd13975   111 VVEGIRFLHSQGLVHRDIKLKNVLLDKKNRAKITDLGFCKpEAM-----MSGSIVGTPIH-MAPE-LFSGKYDNSVDVYA 183
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  889 FGILLWEIFTlGGTPYPE----LPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd13975   184 FGILFWYLCA-GHVKLPEafeqCASKDHLWNNVRKGVRPERLPVFDEECWNLMEACWSGDPSQRP 247
STKc_SLK_like cd06611
Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the ...
807-953 8.39e-15

Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the subfamily include SLK, STK10 (also called LOK for Lymphocyte-Oriented Kinase), SmSLK (Schistosoma mansoni SLK), and related proteins. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It also plays a role in mediating actin reorganization. STK10 is responsible in regulating the CD28 responsive element in T cells, as well as leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. SmSLK is capable of activating the MAPK Jun N-terminal kinase (JNK) pathway in human embryonic kidney cells as well as in Xenopus oocytes. It may participate in regulating MAPK cascades during host-parasite interactions. The SLK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132942 [Multi-domain]  Cd Length: 280  Bit Score: 75.93  E-value: 8.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  807 SYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFG----LARDIMRDSNYIskGSTFlplkWMAPESIF-----N 877
Cdd:cd06611   109 CRQMLEALNFLHSHKVIHRDLKAGNILLTLDGDVKLADFGvsakNKSTLQKRDTFI--GTPY----WMAPEVVAcetfkD 182
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226342982  878 SLYTTLSDVWSFGILLWEIfTLGGTPYPEL-PMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd06611   183 NPYDYKADIWSLGITLIEL-AQMEPPHHELnPMRVLLKILKSEPPTLDQPSKWSSSFNDFLKSCLVKDPDDRPTAAE 258
STKc_LRRK cd14000
Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the ...
785-953 1.20e-14

Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. Vertebrates contain two members, LRRK1 and LRRK2, which show complementary expression in the brain. Mutations in LRRK2 are linked to both familial and sporadic forms of Parkinson's disease. The normal roles of LRRKs are not clearly defined. They may be involved in mitogen-activated protein kinase (MAPK) pathways, protein translation control, programmed cell death pathways, and cytoskeletal dynamics. The LRRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270902 [Multi-domain]  Cd Length: 275  Bit Score: 75.34  E-value: 1.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  785 RTYRATLINDSPVLSYTdlvgFSYQVANGMDFLASKNCVHRDLAARNVLIC-----EGKLVKICDFGLARDIMRDSnyiS 859
Cdd:cd14000   100 QQDSRSFASLGRTLQQR----IALQVADGLRYLHSAMIIYRDLKSHNVLVWtlypnSAIIIKIADYGISRQCCRMG---A 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  860 KGSTFLPlKWMAPESI-FNSLYTTLSDVWSFGILLWEIFTlGGTPYPElpmNDQFYNAIKRGYRMAQPAHASDEIY---- 934
Cdd:cd14000   173 KGSEGTP-GFRAPEIArGNVIYNEKVDVFSFGMLLYEILS-GGAPMVG---HLKFPNEFDIHGGLRPPLKQYECAPwpev 247
                         170       180
                  ....*....|....*....|
gi 226342982  935 -EIMQKCWEEKFETRPPFSQ 953
Cdd:cd14000   248 eVLMKKCWKENPQQRPTAVT 267
STKc_PAK cd06614
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the ...
809-949 1.49e-14

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. PAK deregulation is associated with tumor development. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). Group II PAKs contain a PBD and a catalytic domain, but lack other motifs found in group I PAKs. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. Group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX; no such binding has been demonstrated for group II PAKs. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270789 [Multi-domain]  Cd Length: 255  Bit Score: 74.94  E-value: 1.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-----MRDSNYiskGSTFlplkWMAPESIFNSLYTTL 883
Cdd:cd06614   105 EVLQGLEYLHSQNVIHRDIKSDNILLSKDGSVKLADFGFAAQLtkeksKRNSVV---GTPY----WMAPEVIKRKDYGPK 177
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226342982  884 SDVWSFGILLWEIfTLGGTPYPEL-PMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd06614   178 VDIWSLGIMCIEM-AEGEPPYLEEpPLRALFLITTKGIPPLKNPEKWSPEFKDFLNKCLVKDPEKRP 243
STKc_SBK1 cd13987
Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the ...
807-914 1.54e-14

Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SBK1, also called BSK146, is predominantly expressed in the brain. Its expression is increased in the developing brain during the late embryonic stage, coinciding with dramatic neuronal proliferation, migration, and maturation. SBK1 may play an important role in regulating brain development. The SBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270889 [Multi-domain]  Cd Length: 259  Bit Score: 74.67  E-value: 1.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  807 SYQVANGMDFLASKNCVHRDLAARNVLICEGKL--VKICDFGLARdimRDSNYISKGSTFLPlkWMAPE---SIFNSLYT 881
Cdd:cd13987    97 AAQLASALDFMHSKNLVHRDIKPENVLLFDKDCrrVKLCDFGLTR---RVGSTVKRVSGTIP--YTAPEvceAKKNEGFV 171
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 226342982  882 --TLSDVWSFGILLWEIFTlGGTPYPELPMNDQFY 914
Cdd:cd13987   172 vdPSIDVWAFGVLLFCCLT-GNFPWEKADSDDQFY 205
PTK_Jak_rpt1 cd05037
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak ...
809-953 1.68e-14

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily is composed of Jak1, Jak2, Jak3, TYK2, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. It modulates the kinase activity of the C-terminal catalytic domain. In the case of Jak2, the presumed pseudokinase (repeat 1) domain exhibits dual-specificity kinase activity, phosphorylating two negative regulatory sites in Jak2: Ser523 and Tyr570. Most Jaks are expressed in a wide variety of tissues, except for Jak3, which is expressed only in hematopoietic cells. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). Jaks are also involved in regulating the surface expression of some cytokine receptors. The Jak-STAT pathway is involved in many biological processes including hematopoiesis, immunoregulation, host defense, fertility, lactation, growth, and embryogenesis. The Jak subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270633 [Multi-domain]  Cd Length: 259  Bit Score: 74.82  E-value: 1.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICE------GKLVKICDFGLARDIMRDSNYISkgstflPLKWMAPESIFN--SLY 880
Cdd:cd05037   110 QLASALHYLEDKKLIHGNVRGRNILLARegldgyPPFIKLSDPGVPITVLSREERVD------RIPWIAPECLRNlqANL 183
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  881 TTLSDVWSFGILLWEIFTLGGTPYPELPMND--QFYnaiKRGYRMAQPAHAsdEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd05037   184 TIAADKWSFGTTLWEICSGGEEPLSALSSQEklQFY---EDQHQLPAPDCA--ELAELIMQCWTYEPTKRPSFRA 253
STKc_YSK4 cd06631
Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs ...
806-953 2.48e-14

Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. YSK4 is a putative MAPKKK, whose mammalian gene has been isolated. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The YSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270801 [Multi-domain]  Cd Length: 266  Bit Score: 74.40  E-value: 2.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLK----WMAPESIFNSLYT 881
Cdd:cd06631   108 YTKQILEGVAYLHNNNVIHRDIKGNNIMLMPNGVIKLIDFGCAKRLCINLSSGSQSQLLKSMRgtpyWMAPEVINETGHG 187
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982  882 TLSDVWSFGILLWEIFTlGGTPYPEL-PMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd06631   188 RKSDIWSIGCTVFEMAT-GKPPWADMnPMAAIFAIGSGRKPVPRLPDKFSPEARDFVHACLTRDQDERPSAEQ 259
IgI_4_SCFR cd05860
Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR); member of the ...
305-413 2.68e-14

Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR); member of the I-set of IgSF domains; The members here are composed of the fourth Immunoglobulin (Ig)-like domain in stem cell factor receptor (SCFR). SCFR is organized as an extracellular component having five IG-like domains, a transmembrane segment, and a cytoplasmic portion having protein tyrosine kinase activity. SCFR and its ligand SCF are critical for normal hematopoiesis, mast cell development, melanocytes, and gametogenesis. SCF binds to the second and third Ig-like domains of SCFR. This fourth Ig-like domain participates in SCFR dimerization, which follows ligand binding. Deletion of this fourth domain abolishes the ligand-induced dimerization of SCFR and completely inhibits signal transduction. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409446  Cd Length: 101  Bit Score: 69.89  E-value: 2.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  305 INISVIENGYVRLleTLGDveiaelhrSRTLRVVFEAYPMP-SVLWLKDNRTLGDSGagELVLSTRNMSETRYVSELILV 383
Cdd:cd05860     3 INITPVDNTTIFV--NAGE--------NLDLRVEYEAYPKPeHQVWIYMNETLTNTS--DHYVKSKTEGNNRYVSELHLT 70
                          90       100       110
                  ....*....|....*....|....*....|
gi 226342982  384 RVKVSEAGYYTMRAFHEDDEVQLSFKLQVN 413
Cdd:cd05860    71 RLKGTEGGIYTFLVSNSDASASVTFNVYVK 100
PKc_TESK cd14155
Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; ...
791-896 2.74e-14

Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TESK proteins phosphorylate cofilin and induce actin cytoskeletal reorganization. In the Drosphila eye, TESK is required for epithelial cell organization. Mammals contain two TESK proteins, TESK1 and TESK2, which are highly expressed in testis and play roles in spermatogenesis. TESK1 is found in testicular germ cells while TESK2 is expressed mainly in nongerminal Sertoli cells. TESK1 is stimulated by integrin-mediated signaling pathways. It regulates cell spreading and focal adhesion formation. The TESK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271057 [Multi-domain]  Cd Length: 253  Bit Score: 74.05  E-value: 2.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  791 LINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLI--CEGKLVKIC-DFGLARDIMRDSNYISK----GST 863
Cdd:cd14155    78 LLDSNEPLSWTVRVKLALDIARGLSYLHSKGIFHRDLTSKNCLIkrDENGYTAVVgDFGLAEKIPDYSDGKEKlavvGSP 157
                          90       100       110
                  ....*....|....*....|....*....|...
gi 226342982  864 FlplkWMAPESIFNSLYTTLSDVWSFGILLWEI 896
Cdd:cd14155   158 Y----WMAPEVLRGEPYNEKADVFSYGIILCEI 186
STKc_CDK4_6_like cd07838
Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; ...
807-899 3.19e-14

Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 and CDK6 partner with D-type cyclins to regulate the early G1 phase of the cell cycle. They are the first kinases activated by mitogenic signals to release cells from the G0 arrested state. CDK4 and CDK6 are both expressed ubiquitously, associate with all three D cyclins (D1, D2 and D3), and phosphorylate the retinoblastoma (pRb) protein. They are also regulated by the INK4 family of inhibitors which associate with either the CDK alone or the CDK/cyclin complex. CDK4 and CDK6 show differences in subcellular localization, sensitivity to some inhibitors, timing in activation, tumor selectivity, and possibly substrate profiles. Although CDK4 and CDK6 seem to show some redundancy, they also have discrete, nonoverlapping functions. CDK6 plays an important role in cell differentiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4/6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270831 [Multi-domain]  Cd Length: 287  Bit Score: 74.62  E-value: 3.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  807 SYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrdSNYISKGSTFLPLKWMAPESIFNSLYTTLSDV 886
Cdd:cd07838   113 MRQLLRGLDFLHSHRIVHRDLKPQNILVTSDGQVKLADFGLARIY---SFEMALTSVVVTLWYRAPEVLLQSSYATPVDM 189
                          90
                  ....*....|...
gi 226342982  887 WSFGILLWEIFTL 899
Cdd:cd07838   190 WSVGCIFAELFNR 202
PKc_Pek1_like cd06621
Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
810-905 3.34e-14

Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Pek1/Skh1 from Schizosaccharomyces pombe and MKK2 from Saccharomyces cerevisiae, and related proteins. Both fission yeast Pek1 and baker's yeast MKK2 are components of the cell integrity MAPK pathway. In fission yeast, Pek1 phosphorylates and activates Pmk1/Spm1 and is regulated by the MAPKK kinase Mkh1. In baker's yeast, the pathway involves the MAPK Slt2, the MAPKKs MKK1 and MKK2, and the MAPKK kinase Bck1. The cell integrity MAPK cascade is activated by multiple stress conditions, and is essential in cell wall construction, morphogenesis, cytokinesis, and ion homeostasis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270793 [Multi-domain]  Cd Length: 287  Bit Score: 74.38  E-value: 3.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRdsnyiSKGSTFLPLK-WMAPESIFNSLYTTLSDVWS 888
Cdd:cd06621   114 VLKGLSYLHSRKIIHRDIKPSNILLTRKGQVKLCDFGVSGELVN-----SLAGTFTGTSyYMAPERIQGGPYSITSDVWS 188
                          90
                  ....*....|....*..
gi 226342982  889 FGILLWEIfTLGGTPYP 905
Cdd:cd06621   189 LGLTLLEV-AQNRFPFP 204
STKc_EIF2AK cd13996
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
606-897 3.81e-14

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: General Control Non-derepressible-2 (GCN2) which is activated during amino acid or serum starvation; protein kinase regulated by RNA (PKR) which is activated by double stranded RNA; heme-regulated inhibitor kinase (HRI) which is activated under heme-deficient conditions; and PKR-like endoplasmic reticulum kinase (PERK) which is activated when misfolded proteins accumulate in the ER. The EIF2AK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270898 [Multi-domain]  Cd Length: 273  Bit Score: 73.87  E-value: 3.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEAtahglSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITEYCR 685
Cdd:cd13996    14 LGSGGFGSVYKV-----RNKVDGVTYAIKKIRLTEKSSASEKVLREVKALAKLN-HPNIVRYYTAWVEEPPLYIQMELCE 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  686 YGDLVDYLHRnkhtflqrhSNKHCppsaelysnalpvgfslpshlnltgesdggymDMSKDESIDYVpmldmkgdikyad 765
Cdd:cd13996    88 GGTLRDWIDR---------RNSSS--------------------------------KNDRKLALELF------------- 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  766 iespsymapydnyvpsapertyratlindspvlsytdlvgfsYQVANGMDFLASKNCVHRDLAARNVLICEG-KLVKICD 844
Cdd:cd13996   114 ------------------------------------------KQILKGVSYIHSKGIVHRDLKPSNIFLDNDdLQVKIGD 151
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  845 FGLARDI---------------MRDSNYISKGSTFLplkWMAPESIFNSLYTTLSDVWSFGILLWEIF 897
Cdd:cd13996   152 FGLATSIgnqkrelnnlnnnnnGNTSNNSVGIGTPL---YASPEQLDGENYNEKADIYSLGIILFEML 216
PKc_TNNI3K cd14064
Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; ...
807-953 3.98e-14

Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TNNI3K, also called cardiac ankyrin repeat kinase (CARK), is a cardiac-specific troponin I-interacting kinase that promotes cardiac myogenesis, improves cardiac performance, and protects the myocardium from ischemic injury. It contains N-terminal ankyrin repeats, a catalytic kinase domain, and a C-terminal serine-rich domain. TNNI3K exerts a disease-accelerating effect on cardiac dysfunction and reduced survival in mouse models of cardiomyopathy. The TNNI3K subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270966 [Multi-domain]  Cd Length: 254  Bit Score: 73.72  E-value: 3.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  807 SYQVANGMDFL--ASKNCVHRDLAARNVLICEGKLVKICDFGLARDI--MRDSNYISKGSTflpLKWMAPEsIF--NSLY 880
Cdd:cd14064    99 AVDVAKGMEYLhnLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLqsLDEDNMTKQPGN---LRWMAPE-VFtqCTRY 174
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226342982  881 TTLSDVWSFGILLWEIFTlGGTPY----PELPMNDQFYNAIKRGYRMAQPAHasdeIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14064   175 SIKADVFSYALCLWELLT-GEIPFahlkPAAAAADMAYHHIRPPIGYSIPKP----ISSLLMRGWNAEPESRPSFVE 246
STKc_Pat1_like cd13993
Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of ...
606-920 4.90e-14

Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Pat1 (also called Ran1), Saccharomyces cerevisiae VHS1 and KSP1, and similar fungal STKs. Pat1 blocks Mei2, an RNA-binding protein which is indispensable in the initiation of meiosis. Pat1 is inactivated and Mei2 activated, which initiates meiosis, under nutrient-deprived conditions through a signaling cascade involving Ste11. Meiosis induced by Pat1 inactivation may show different characteristics than normal meiosis including aberrant positioning of centromeres. VHS1 was identified in a screen for suppressors of cell cycle arrest at the G1/S transition, while KSP1 may be involved in regulating PRP20, which is required for mRNA export and maintenance of nuclear structure. The Pat1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270895 [Multi-domain]  Cd Length: 267  Bit Score: 73.54  E-value: 4.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATahglsHSQATMKVAVKML-KSTARSSEKQAL-----MSELKIMSHLGPHLNVVNLLGACTKGGPIYI 679
Cdd:cd13993     8 IGEGAYGVVYLAV-----DLRTGRKYAIKCLyKSGPNSKDGNDFqklpqLREIDLHRRVSRHPNIITLHDVFETEVAIYI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  680 ITEYCRYGDLVDYLHrnkhtflqrhSNKHCPPSAELYSNAlpvgfslpshlnltgesdggymdmskdesidyvpMLdmkg 759
Cdd:cd13993    83 VLEYCPNGDLFEAIT----------ENRIYVGKTELIKNV----------------------------------FL---- 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  760 dikyadiespsymapydnyvpsapertyratlindspvlsytdlvgfsyQVANGMDFLASKNCVHRDLAARNVLI-CEGK 838
Cdd:cd13993   115 -------------------------------------------------QLIDAVKHCHSLGIYHRDIKPENILLsQDEG 145
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  839 LVKICDFGLARDIMRDSNYiSKGSTFlplkWMAPESI-----FNSLYTTLS-DVWSFGILLWEIfTLGGTPYPE------ 906
Cdd:cd13993   146 TVKLCDFGLATTEKISMDF-GVGSEF----YMAPECFdevgrSLKGYPCAAgDIWSLGIILLNL-TFGRNPWKIasesdp 219
                         330       340       350
                  ....*....|....*....|....*....|
gi 226342982  907 ----------------LPMNDQFYNAIKRG 920
Cdd:cd13993   220 ifydyylnspnlfdviLPMSDDFYNLLRQI 249
STKc_ERK1_2_like cd07849
Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine ...
795-898 5.46e-14

Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the mitogen-activated protein kinases (MAPKs) ERK1, ERK2, baker's yeast Fus3, and similar proteins. MAPK pathways are important mediators of cellular responses to extracellular signals. ERK1/2 activation is preferentially by mitogenic factors, differentiation stimuli, and cytokines, through a kinase cascade involving the MAPK kinases MEK1/2 and a MAPK kinase kinase from the Raf family. ERK1/2 have numerous substrates, many of which are nuclear and participate in transcriptional regulation of many cellular processes. They regulate cell growth, cell proliferation, and cell cycle progression from G1 to S phase. Although the distinct roles of ERK1 and ERK2 have not been fully determined, it is known that ERK2 can maintain most functions in the absence of ERK1, and that the deletion of ERK2 is embryonically lethal. The MAPK, Fus3, regulates yeast mating processes including mating-specific gene expression, G1 arrest, mating projection, and cell fusion. This ERK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270839 [Multi-domain]  Cd Length: 336  Bit Score: 74.65  E-value: 5.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  795 SPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWM-APE 873
Cdd:cd07849   100 TQHLSNDHIQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTNCDLKICDFGLARIADPEHDHTGFLTEYVATRWYrAPE 179
                          90       100
                  ....*....|....*....|....*.
gi 226342982  874 SIFNS-LYTTLSDVWSFGILLWEIFT 898
Cdd:cd07849   180 IMLNSkGYTKAIDIWSVGCILAEMLS 205
PK_GC-A_B cd14042
Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B; The ...
631-953 8.36e-14

Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity and/or ATP binding. GC-A binds and is activated by the atrial and B-type natriuretic peptides, ANP and BNP, which are important in blood pressure regulation and cardiac pathophysiology. GC-B binds the C-type natriuretic peptide, CNP, which is a potent vasorelaxant and functions in vascular remodeling and bone growth regulation. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC-A/B subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270944 [Multi-domain]  Cd Length: 279  Bit Score: 73.01  E-value: 8.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  631 VAVKMLKSTARSSEKQALMsELKIMSHLgPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLhRNkhtflqrhsnkhcp 710
Cdd:cd14042    33 VAIKKVNKKRIDLTREVLK-ELKHMRDL-QHDNLTRFIGACVDPPNICILTEYCPKGSLQDIL-EN-------------- 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  711 psaelysnalpvgfslpshlnltgesdggymdmskdESIDyvpmLDmkgdikyadiespsYMapydnyvpsapertYRAT 790
Cdd:cd14042    96 ------------------------------------EDIK----LD--------------WM--------------FRYS 107
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  791 LINDspvlsytdlvgfsyqVANGMDF-----------LASKNCVhrdLAARNVLicegklvKICDFGLAR------DIMR 853
Cdd:cd14042   108 LIHD---------------IVKGMHYlhdseikshgnLKSSNCV---VDSRFVL-------KITDFGLHSfrsgqePPDD 162
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  854 DSNYISKgstflpLKWMAPE----SIFNSLYTTLSDVWSFGILLWEIFTLGGTPY---PELPMNDQFYNAIKRGYRMA-- 924
Cdd:cd14042   163 SHAYYAK------LLWTAPEllrdPNPPPPGTQKGDVYSFGIILQEIATRQGPFYeegPDLSPKEIIKKKVRNGEKPPfr 236
                         330       340       350
                  ....*....|....*....|....*....|..
gi 226342982  925 ---QPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14042   237 pslDELECPDEVLSLMQRCWAEDPEERPDFST 268
STKc_ATG1_ULK_like cd14009
Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like ...
606-903 9.64e-14

Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes yeast ATG1 and metazoan homologs including vertebrate ULK1-3. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. It is involved in nutrient sensing and signaling, the assembly of autophagy factors and the execution of autophagy. In metazoans, ATG1 homologs display additional functions. Unc-51 and ULKs have been implicated in neuronal and axonal development. The ATG1/ULK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270911 [Multi-domain]  Cd Length: 251  Bit Score: 72.26  E-value: 9.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEATahglsHSQATMKVAVKMLkSTARSSEK--QALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITEY 683
Cdd:cd14009     1 IGRGSFATVWKGR-----HKQTGEVVAIKEI-SRKKLNKKlqENLESEIAILKSIK-HPNIVRLYDVQKTEDFIYLVLEY 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  684 CRYGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgdiky 763
Cdd:cd14009    74 CAGGDLSQYIRKRG------------------------------------------------------------------ 87
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  764 adiespsymapydnyvpSAPERTYRAtlindspvlsytdlvgFSYQVANGMDFLASKNCVHRDLAARNVLIC---EGKLV 840
Cdd:cd14009    88 -----------------RLPEAVARH----------------FMQQLASGLKFLRSKNIIHRDLKPQNLLLStsgDDPVL 134
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  841 KICDFGLARdIMRDSNYISK--GStflPLkWMAPESIFNSLYTTLSDVWSFGILLWEIFTlgGTP 903
Cdd:cd14009   135 KIADFGFAR-SLQPASMAETlcGS---PL-YMAPEILQFQKYDAKADLWSVGAILFEMLV--GKP 192
STKc_NAK1_like cd06917
Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of ...
814-908 1.02e-13

Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Nak1, Saccharomyces cerevisiae Kic1p (kinase that interacts with Cdc31p) and related proteins. Nak1 (also called N-rich kinase 1), is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Kic1p is required by budding yeast for cell integrity and morphogenesis. Kic1p interacts with Cdc31p, the yeast homologue of centrin, and phosphorylates substrates in a Cdc31p-dependent manner. The Nak1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270822 [Multi-domain]  Cd Length: 277  Bit Score: 72.89  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  814 MDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyiSKGSTFL--PLkWMAPESIFNS-LYTTLSDVWSFG 890
Cdd:cd06917   114 LKFIHKDGIIHRDIKAANILVTNTGNVKLCDFGVAASLNQNS---SKRSTFVgtPY-WMAPEVITEGkYYDTKADIWSLG 189
                          90
                  ....*....|....*...
gi 226342982  891 ILLWEIFTlGGTPYPELP 908
Cdd:cd06917   190 ITTYEMAT-GNPPYSDVD 206
STKc_ULK3 cd14121
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the ...
606-904 1.21e-13

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK3 mRNA is up-regulated in fibroblasts after Ras-induced senescence, and its overexpression induces both autophagy and senescence in a fibroblast cell line. ULK3, through its kinase activity, positively regulates Gli proteins, mediators of the Sonic hedgehog (Shh) signaling pathway that is implicated in tissue homeostasis maintenance and neurogenesis. It is inhibited by binding to Suppressor of Fused (Sufu). The ULK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271023 [Multi-domain]  Cd Length: 252  Bit Score: 71.94  E-value: 1.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEAtahgLSHSQATMKVAVK-MLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACTKGGPIYIITEYC 684
Cdd:cd14121     3 LGSGTYATVYKA----YRKSGAREVVAVKcVSKSSLNKASTENLLTEIELLKKL-KHPHIVELKDFQWDEEHIYLIMEYC 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  685 RYGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpMLdmkgdikya 764
Cdd:cd14121    78 SGGDLSRFIRSRR--------------------------------------------------------TL--------- 92
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  765 diespsymapydnyvpsaPERTYRAtlindspvlsytdlvgFSYQVANGMDFLASKNCVHRDLAARNVLICEGK--LVKI 842
Cdd:cd14121    93 ------------------PESTVRR----------------FLQQLASALQFLREHNISHMDLKPQNLLLSSRYnpVLKL 138
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982  843 CDFGLARDIM-RDSNYISKGStflPLkWMAPESIFNSLYTTLSDVWSFGILLWEIFtLGGTPY 904
Cdd:cd14121   139 ADFGFAQHLKpNDEAHSLRGS---PL-YMAPEMILKKKYDARVDLWSVGVILYECL-FGRAPF 196
STKc_CNK2-like cd08530
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar ...
809-953 1.23e-13

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii CNK2 has both cilliary and cell cycle functions. It influences flagellar length through promoting flagellar disassembly, and it regulates cell size, through influencing the size threshold at which cells commit to mitosis. This subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily includes CNK1, and -2. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270869 [Multi-domain]  Cd Length: 256  Bit Score: 72.04  E-value: 1.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFlplkWMAPESIFNSLYTTLSDVWS 888
Cdd:cd08530   111 QMLRGLKALHDQKILHRDLKSANILLSAGDLVKIGDLGISKVLKKNLAKTQIGTPL----YAAPEVWKGRPYDYKSDIWS 186
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  889 FGILLWEIFTLgGTPYPELPMNDqFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd08530   187 LGCLLYEMATF-RPPFEARTMQE-LRYKVCRGKFPPIPPVYSQDLQQIIRSLLQVNPKKRPSCDK 249
STKc_CDK_like cd07829
Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs ...
806-915 1.25e-13

Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDKs are partly regulated by their subcellular localization, which defines substrate phosphorylation and the resulting specific function. CDK1, CDK2, CDK4, and CDK6 have well-defined functions in the cell cycle, such as the regulation of the early G1 phase by CDK4 or CDK6, the G1/S phase transition by CDK2, or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes, showing that some CDKs can compensate for each other. For example, CDK4 can compensate for the loss of CDK6, however, double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270823 [Multi-domain]  Cd Length: 282  Bit Score: 72.51  E-value: 1.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLplkWM-APESIFNS-LYTTL 883
Cdd:cd07829   103 IMYQLLRGLAYCHSHRILHRDLKPQNLLINRDGVLKLADFGLARAFGIPLRTYTHEVVTL---WYrAPEILLGSkHYSTA 179
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  884 SDVWSFG-IL------------------LWEIFTLGGTP----YPELPMNDQFYN 915
Cdd:cd07829   180 VDIWSVGcIFaelitgkplfpgdseidqLFKIFQILGTPteesWPGVTKLPDYKP 234
STKc_STK36 cd14002
Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the ...
807-903 1.97e-13

Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK36, also called Fused (or Fu) kinase, is involved in the Hedgehog signaling pathway. It is activated by the Smoothened (SMO) signal transducer, resulting in the stabilization of GLI transcription factors and the phosphorylation of SUFU to facilitate the nuclear accumulation of GLI. In Drosophila, Fused kinase is maternally required for proper segmentation during embryonic development and for the development of legs and wings during the larval stage. In mice, STK36 is not necessary for embryonic development, although mice deficient in STK36 display growth retardation postnatally. The STK36 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270904 [Multi-domain]  Cd Length: 253  Bit Score: 71.51  E-value: 1.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  807 SYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYIS--KGStflPLkWMAPESIFNSLYTTLS 884
Cdd:cd14002   105 AKQLVSALHYLHSNRIIHRDMKPQNILIGKGGVVKLCDFGFARAMSCNTLVLTsiKGT---PL-YMAPELVQEQPYDHTA 180
                          90
                  ....*....|....*....
gi 226342982  885 DVWSFGILLWEIFTlgGTP 903
Cdd:cd14002   181 DLWSLGCILYELFV--GQP 197
STKc_cGK cd05572
Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); ...
809-920 2.76e-13

Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mammals have two cGK isoforms from different genes, cGKI and cGKII. cGKI exists as two splice variants, cGKI-alpha and cGKI-beta. cGK consists of an N-terminal regulatory domain containing a dimerization and an autoinhibitory pseudosubstrate region, two cGMP-binding domains, and a C-terminal catalytic domain. Binding of cGMP to both binding sites releases the inhibition of the catalytic center by the pseudosubstrate region, allowing autophosphorylation and activation of the kinase. cGKI is a soluble protein expressed in all smooth muscles, platelets, cerebellum, and kidney. It is also expressed at lower concentrations in other tissues. cGKII is a membrane-bound protein that is most abundantly expressed in the intestine. It is also present in the brain nuclei, adrenal cortex, kidney, lung, and prostate. cGKI is involved in the regulation of smooth muscle tone, smooth cell proliferation, and platelet activation. cGKII plays a role in the regulation of secretion, such as renin secretion by the kidney and aldosterone secretion by the adrenal. It also regulates bone growth and the circadian rhythm. The cGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270724 [Multi-domain]  Cd Length: 262  Bit Score: 71.10  E-value: 2.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyisKGSTFL--PlKWMAPESIFNSLYTTLSDV 886
Cdd:cd05572   101 CVVLAFEYLHSRGIIYRDLKPENLLLDSNGYVKLVDFGFAKKLGSGR----KTWTFCgtP-EYVAPEIILNKGYDFSVDY 175
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 226342982  887 WSFGILLWEIFTlGGTPYPElPMNDQF--YNAIKRG 920
Cdd:cd05572   176 WSLGILLYELLT-GRPPFGG-DDEDPMkiYNIILKG 209
STKc_CDK6 cd07862
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs ...
767-897 3.73e-13

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK6 is regulated by D-type cyclins and INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein, implicating it to function in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the cytoplasm. It is also present in the ruffling edge of spreading fibroblasts and may play a role in cell spreading. It binds to the p21 inhibitor without any effect on its own activity and it is overexpressed in squamous cell carcinomas and neuroblastomas. CDK6 has also been shown to inhibit cell differentiation in many cell types. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270846 [Multi-domain]  Cd Length: 290  Bit Score: 71.22  E-value: 3.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  767 ESPSYMAPYDNYVPSAPERTYRATLI---NDSPVLSYTDLV-----------GFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd07862    62 EHPNVVRLFDVCTVSRTDRETKLTLVfehVDQDLTTYLDKVpepgvptetikDMMFQLLRGLDFLHSHRVVHRDLKPQNI 141
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  833 LICEGKLVKICDFGLARDImrdSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIF 897
Cdd:cd07862   142 LVTSSGQIKLADFGLARIY---SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 203
STKc_CDKL cd07833
Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs ...
601-914 6.30e-13

Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDKL1-5 and similar proteins. Some CDKLs, like CDKL1 and CDKL3, may be implicated in transformation and others, like CDKL3 and CDKL5, are associated with mental retardation when impaired. CDKL2 plays a role in learning and memory. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270827 [Multi-domain]  Cd Length: 288  Bit Score: 70.42  E-value: 6.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  601 VLGRTlGSGAFGQVVEAtahglSHSQATMKVAVKMLKsTARSSE--KQALMSELKIMSHLgPHLNVVNLLGACTKGGPIY 678
Cdd:cd07833     5 VLGVV-GEGAYGVVLKC-----RNKATGEIVAIKKFK-ESEDDEdvKKTALREVKVLRQL-RHENIVNLKEAFRRKGRLY 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  679 IITEYCrygdlvdylHRNKHTFLqrhsnkhcppsaELYSNALPvgfslpshlnltgesdggymdmskdesIDYVpmldmk 758
Cdd:cd07833    77 LVFEYV---------ERTLLELL------------EASPGGLP---------------------------PDAV------ 102
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  759 gdikyadiespsymapydnyvpsapeRTYratlindspvlsytdlvgfSYQVANGMDFLASKNCVHRDLAARNVLICEGK 838
Cdd:cd07833   103 --------------------------RSY-------------------IWQLLQAIAYCHSHNIIHRDIKPENILVSESG 137
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  839 LVKICDFGLARDIM--RDSNYISKGSTflplKWM-APESIFNSL-YTTLSDVWSFGILLWEIFTlgGTP-YPELPMNDQF 913
Cdd:cd07833   138 VLKLCDFGFARALTarPASPLTDYVAT----RWYrAPELLVGDTnYGKPVDVWAIGCIMAELLD--GEPlFPGDSDIDQL 211

                  .
gi 226342982  914 Y 914
Cdd:cd07833   212 Y 212
STKc_ULK1 cd14202
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the ...
593-914 6.45e-13

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. It associates with three autophagy-related proteins (Atg13, FIP200 amd Atg101) to form the ULK1 complex. All fours proteins are essential for autophagosome formation. ULK1 is regulated by both mammalian target-of rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK). mTORC1 negatively regulates the ULK1 complex in a nutrient-dependent manner while AMPK stimulates autophagy by inhibiting mTORC1. ULK1 also plays neuron-specific roles and is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, neurite extension, and axon branching. The ULK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271104 [Multi-domain]  Cd Length: 267  Bit Score: 70.42  E-value: 6.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  593 WELPRDQLVlgrtlGSGAFGQVVEatahGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACT 672
Cdd:cd14202     2 FEFSRKDLI-----GHGAFAVVFK----GRHKEKHDLEVAVKCINKKNLAKSQTLLGKEIKILKEL-KHENIVALYDFQE 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  673 KGGPIYIITEYCRYGDLVDYLHrnkhtflqrhsNKHCppsaelysnalpvgfslpshlnltgesdggymdMSKDesidyv 752
Cdd:cd14202    72 IANSVYLVMEYCNGGDLADYLH-----------TMRT---------------------------------LSED------ 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  753 pmldmkgdikyadiespsymapydnyvpsaperTYRAtlindspvlsytdlvgFSYQVANGMDFLASKNCVHRDLAARNV 832
Cdd:cd14202   102 ---------------------------------TIRL----------------FLQQIAGAMKMLHSKGIIHRDLKPQNI 132
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  833 LI-CEGK--------LVKICDFGLARDImrDSNYISKGSTFLPLkWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTP 903
Cdd:cd14202   133 LLsYSGGrksnpnniRIKIADFGFARYL--QNNMMAATLCGSPM-YMAPEVIMSQHYDAKADLWSIGTIIYQCLT-GKAP 208
                         330
                  ....*....|...
gi 226342982  904 YPELPMND--QFY 914
Cdd:cd14202   209 FQASSPQDlrLFY 221
STKc_Bck1_like cd06629
Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein ...
806-949 6.60e-13

Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Saccharomyces cerevisiae Bck1 and Schizosaccharomyces pombe Mkh1, and related proteins. Budding yeast Bck1 is part of the cell integrity MAPK pathway, which is activated by stresses and aggressions to the cell wall. The MAPKKK Bck1, MAPKKs Mkk1 and Mkk2, and the MAPK Slt2 make up the cascade that is important in the maintenance of cell wall homeostasis. Fission yeast Mkh1 is involved in MAPK cascades regulating cell morphology, cell wall integrity, salt resistance, and filamentous growth in response to stress. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The Bck1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270799 [Multi-domain]  Cd Length: 270  Bit Score: 70.10  E-value: 6.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLAR---DIM-RDSNYISKGSTFlplkWMAPESIFNSL-- 879
Cdd:cd06629   113 FTRQILDGLAYLHSKGILHRDLKADNILVDLEGICKISDFGISKksdDIYgNNGATSMQGSVF----WMAPEVIHSQGqg 188
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  880 YTTLSDVWSFGILLWEIFTlGGTPYPELpmnDQFYNAIKRG-YRMAQP----AHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd06629   189 YSAKVDIWSLGCVVLEMLA-GRRPWSDD---EAIAAMFKLGnKRSAPPvpedVNLSPEALDFLNACFAIDPRDRP 259
STKc_AGC cd05123
Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
809-940 1.10e-12

Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AGC kinases regulate many cellular processes including division, growth, survival, metabolism, motility, and differentiation. Many are implicated in the development of various human diseases. Members of this family include cAMP-dependent Protein Kinase (PKA), cGMP-dependent Protein Kinase (PKG), Protein Kinase C (PKC), Protein Kinase B (PKB), G protein-coupled Receptor Kinase (GRK), Serum- and Glucocorticoid-induced Kinase (SGK), and 70 kDa ribosomal Protein S6 Kinase (p70S6K or S6K), among others. AGC kinases share an activation mechanism based on the phosphorylation of up to three sites: the activation loop (A-loop), the hydrophobic motif (HM) and the turn motif. Phosphorylation at the A-loop is required of most AGC kinases, which results in a disorder-to-order transition of the A-loop. The ordered conformation results in the access of substrates and ATP to the active site. A subset of AGC kinases with C-terminal extensions containing the HM also requires phosphorylation at this site. Phosphorylation at the HM allows the C-terminal extension to form an ordered structure that packs into the hydrophobic pocket of the catalytic domain, which then reconfigures the kinase into an active bi-lobed state. In addition, growth factor-activated AGC kinases such as PKB, p70S6K, RSK, MSK, PKC, and SGK, require phosphorylation at the turn motif (also called tail or zipper site), located N-terminal to the HM at the C-terminal extension. The AGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and Phosphoinositide 3-Kinase.


Pssm-ID: 270693 [Multi-domain]  Cd Length: 250  Bit Score: 69.08  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyiSKGSTFL-PLKWMAPESIFNSLYTTLSDVW 887
Cdd:cd05123   101 EIVLALEYLHSLGIIYRDLKPENILLDSDGHIKLTDFGLAKELSSDG---DRTYTFCgTPEYLAPEVLLGKGYGKAVDWW 177
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 226342982  888 SFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRMaqPAHASDEIYEIMQKC 940
Cdd:cd05123   178 SLGVLLYEMLT-GKPPFYAENRKEIYEKILKSPLKF--PEYVSPEAKSLISGL 227
STKc_myosinIIIA_N cd06638
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze ...
813-953 1.23e-12

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIA myosin is highly expressed in retina and in inner ear hair cells. It is localized to the distal ends of actin-bundled structures. Mutations in human myosin IIIA are responsible for progressive nonsyndromic hearing loss. Human myosin IIIA possesses ATPase and kinase activities, and the ability to move actin filaments in a motility assay. It may function as a cellular transporter capable of moving along actin bundles in sensory cells. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. Class III myosins may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. In photoreceptor cells, they may also function as cargo carriers during light-dependent translocation of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132969 [Multi-domain]  Cd Length: 286  Bit Score: 69.65  E-value: 1.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  813 GMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI--MRDSNYISKGSTFlplkWMAPESI-----FNSLYTTLSD 885
Cdd:cd06638   136 GLQHLHVNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLtsTRLRRNTSVGTPF----WMAPEVIaceqqLDSTYDARCD 211
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226342982  886 VWSFGILLWEIFTlGGTPYPEL-PMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd06638   212 VWSLGITAIELGD-GDPPLADLhPMRALFKIPRNPPPTLHQPELWSNEFNDFIRKCLTKDYEKRPTVSD 279
PKc_PBS2_like cd06622
Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
789-953 1.24e-12

Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Polymyxin B resistance protein 2 (PBS2) from Saccharomyces cerevisiae, Wis1 from Schizosaccharomyces pombe, and related proteins. PBS2 and Wis1 are components of stress-activated MAPK cascades in budding and fission yeast, respectively. PBS2 is the specific activator of the MAPK Hog1, which plays a central role in the response of budding yeast to stress including exposure to arsenite and hyperosmotic environments. Wis1 phosphorylates and activates the MAPK Sty1 (also called Spc1 or Phh1), which stimulates a transcriptional response to a wide range of cellular insults through the bZip transcription factors Atf1, Pcr1, and Pap1. The PBS2 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132953 [Multi-domain]  Cd Length: 286  Bit Score: 69.88  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  789 ATLINDSPVLSYTdlvgfSYQVANGMDFLASK-NCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTflpl 867
Cdd:cd06622    95 ATEGIPEDVLRRI-----TYAVVKGLKFLKEEhNIIHRDVKPTNVLVNGNGQVKLCDFGVSGNLVASLAKTNIGCQ---- 165
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  868 KWMAPESIF------NSLYTTLSDVWSFGILLWEIfTLGGTPYPELPMNDQF--YNAIKRGYRMAQPAHASDEIYEIMQK 939
Cdd:cd06622   166 SYMAPERIKsggpnqNPTYTVQSDVWSLGLSILEM-ALGRYPYPPETYANIFaqLSAIVDGDPPTLPSGYSDDAQDFVAK 244
                         170
                  ....*....|....
gi 226342982  940 CWEEKFETRPPFSQ 953
Cdd:cd06622   245 CLNKIPNRRPTYAQ 258
STKc_LKB1_CaMKK cd14008
Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent ...
808-948 1.54e-12

Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Both LKB1 and CaMKKs can phosphorylate and activate AMP-activated protein kinase (AMPK). LKB1, also called STK11, serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMPK. Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The LKB1/CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270910 [Multi-domain]  Cd Length: 267  Bit Score: 69.12  E-value: 1.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISK--GS-TFlplkwMAPEsIFNSLYTTLS 884
Cdd:cd14008   115 RDLVLGLEYLHENGIVHRDIKPENLLLTADGTVKISDFGVSEMFEDGNDTLQKtaGTpAF-----LAPE-LCDGDSKTYS 188
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982  885 ----DVWSFGILLWeIFTLGgtpypELPMND----QFYNAIKRGYRM-AQPAHASDEIYEIMQKCWEEKFETR 948
Cdd:cd14008   189 gkaaDIWALGVTLY-CLVFG-----RLPFNGdnilELYEAIQNQNDEfPIPPELSPELKDLLRRMLEKDPEKR 255
STKc_STK10 cd06644
Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase ...
809-953 1.57e-12

Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK10/LOK is also called polo-like kinase kinase 1 in Xenopus (xPlkk1). It is highly expressed in lymphocytes and is responsible in regulating leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. It plays a role in regulating the CD28 responsive element in T cells, and may also function as a regulator of polo-like kinase 1 (Plk1), a protein which is overexpressed in multiple tumor types. The STK10 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132975 [Multi-domain]  Cd Length: 292  Bit Score: 69.68  E-value: 1.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLArdiMRDSNYISKGSTFLPLK-WMAPESIF-----NSLYTT 882
Cdd:cd06644   118 QMLEALQYLHSMKIIHRDLKAGNVLLTLDGDIKLADFGVS---AKNVKTLQRRDSFIGTPyWMAPEVVMcetmkDTPYDY 194
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  883 LSDVWSFGILLWEIFTLgGTPYPEL-PMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd06644   195 KADIWSLGITLIEMAQI-EPPHHELnPMRVLLKIAKSEPPTLSQPSKWSMEFRDFLKTALDKHPETRPSAAQ 265
STKc_RIP4_like cd14025
Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar ...
808-953 1.60e-12

Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of RIP4, ankyrin (ANK) repeat and kinase domain containing 1 (ANKK1), and similar proteins, all of which harbor C-terminal ANK repeats. RIP4, also called Protein Kinase C-associated kinase (PKK), regulates keratinocyte differentiation and cutaneous inflammation. It activates NF-kappaB and is important in the survival of diffuse large B-cell lymphoma cells. The ANKK1 protein, also called PKK2, has not been studied extensively. The ANKK1 gene, located less than 10kb downstream of the D2 dopamine receptor (DRD2) locus, is altered in the Taq1 A1 polymorphism, which is related to a reduced DRD2 binding affinity and consequently, to mental disorders. The RIP4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270927 [Multi-domain]  Cd Length: 267  Bit Score: 69.06  E-value: 1.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKN--CVHRDLAARNVLICEGKLVKICDFGLAR--DIMRDSNyISKGSTFLPLKWMAPESIF--NSLYT 881
Cdd:cd14025    99 HETAVGMNFLHCMKppLLHLDLKPANILLDAHYHVKISDFGLAKwnGLSHSHD-LSRDGLRGTIAYLPPERFKekNRCPD 177
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  882 TLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRMAQPA------HASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14025   178 TKHDVYSFAIVIWGILT-QKKPFAGENNILHIMVKVVKGHRPSLSPiprqrpSECQQMICLMKRCWDQDPRKRPTFQD 254
STKc_LIMK2 cd14222
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the ...
792-953 1.90e-12

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK2 activation is induced by transforming growth factor-beta l (TGFb-l) and shares the same subcellular location as the cofilin family member twinfilin, which may be its biological substrate. LIMK2 plays a role in spermatogenesis, and may contribute to tumor progression and metastasis formation in some cancer cells. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271124 [Multi-domain]  Cd Length: 272  Bit Score: 68.82  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  792 INDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIM------------------- 852
Cdd:cd14222    81 LRADDPFPWQQKVSFAKGIASGMAYLHSMSIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVeekkkpppdkpttkkrtlr 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  853 ---RDSNYISKGSTFlplkWMAPESIFNSLYTTLSDVWSFGILLWEIFtlgGTPY--PE-LPMNDQFYNAIKRGYRMAQP 926
Cdd:cd14222   161 kndRKKRYTVVGNPY----WMAPEMLNGKSYDEKVDIFSFGIVLCEII---GQVYadPDcLPRTLDFGLNVRLFWEKFVP 233
                         170       180
                  ....*....|....*....|....*..
gi 226342982  927 AHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14222   234 KDCPPAFFPLAAICCRLEPDSRPAFSK 260
STKc_MST3 cd06641
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs ...
798-949 2.04e-12

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. It may also regulate paxillin and consequently, cell migration. MST3 is present in human placenta, where it plays an essential role in the oxidative stress-induced apoptosis of trophoblasts in normal spontaneous delivery. Dysregulation of trophoblast apoptosis may result in pregnancy complications such as preeclampsia and intrauterine growth retardation. The MST3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270809 [Multi-domain]  Cd Length: 277  Bit Score: 68.95  E-value: 2.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  798 LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDiMRDSNYISKGSTFLPLkWMAPESIFN 877
Cdd:cd06641    98 LDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQ-LTDTQIKRN*FVGTPF-WMAPEVIKQ 175
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982  878 SLYTTLSDVWSFGILLWEIfTLGGTPYPEL-PMNDQFYnaIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd06641   176 SAYDSKADIWSLGITAIEL-ARGEPPHSELhPMKVLFL--IPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRP 245
STKc_MPK1 cd07857
Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; ...
806-903 2.11e-12

Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs MPK1 from Saccharomyces cerevisiae, Pmk1 from Schizosaccharomyces pombe, and similar proteins. MPK1 (also called Slt2) and Pmk1 (also called Spm1) are stress-activated MAPKs that regulate the cell wall integrity pathway, and are therefore important in the maintainance of cell shape, cell wall construction, morphogenesis, and ion homeostasis. MPK1 is activated in response to cell wall stress including heat stimulation, osmotic shock, UV irradiation, and any agents that interfere with cell wall biogenesis such as chitin antagonists, caffeine, or zymolase. MPK1 is regulated by the MAP2Ks Mkk1/2, which are regulated by the MAP3K Bck1. Pmk1 is also activated by multiple stresses including elevated temperatures, hyper- or hypotonic stress, glucose deprivation, exposure to cell-wall damaging compounds, and oxidative stress. It is regulated by the MAP2K Pek1, which is regulated by the MAP3K Mkh1. MAPKs are important mediators of cellular responses to extracellular signals. The MPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173750 [Multi-domain]  Cd Length: 332  Bit Score: 69.74  E-value: 2.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI----MRDSNYISKgstFLPLKWM-APESIF-NSL 879
Cdd:cd07857   110 FIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFsenpGENAGFMTE---YVATRWYrAPEIMLsFQS 186
                          90       100
                  ....*....|....*....|....
gi 226342982  880 YTTLSDVWSFGILLWEIftLGGTP 903
Cdd:cd07857   187 YTKAIDVWSVGCILAEL--LGRKP 208
PKc_Mps1 cd14131
Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle ...
820-949 2.31e-12

Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK); Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TTK/Mps1 is a spindle checkpoint kinase that was first discovered due to its necessity in centrosome duplication in budding yeast. It was later found to function in the spindle assembly checkpoint, which monitors the proper attachment of chromosomes to the mitotic spindle. In yeast, substrates of Mps1 include the spindle pole body components Spc98p, Spc110p, and Spc42p. The TTK/Mps1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271033 [Multi-domain]  Cd Length: 271  Bit Score: 68.78  E-value: 2.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  820 KNCVHRDLAARNVLICEGKLvKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTL----------SDVWSF 889
Cdd:cd14131   122 EGIVHSDLKPANFLLVKGRL-KLIDFGIAKAIQNDTTSIVRDSQVGTLNYMSPEAIKDTSASGEgkpkskigrpSDVWSL 200
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226342982  890 GILLWEiFTLGGTPYPELPMNDQFYNAI-KRGYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd14131   201 GCILYQ-MVYGKTPFQHITNPIAKLQAIiDPNHEIEFPDIPNPDLIDVMKRCLQRDPKKRP 260
PKc_Byr1_like cd06620
Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; ...
801-916 2.34e-12

Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Byr1 from Schizosaccharomyces pombe, FUZ7 from Ustilago maydis, and related proteins. Byr1 phosphorylates its downstream target, the MAPK Spk1, and is regulated by the MAPKK kinase Byr2. The Spk1 cascade is pheromone-responsive and is essential for sporulation and sexual differentiation in fission yeast. FUZ7 phosphorylates and activates its target, the MAPK Crk1, which is required in mating and virulence in U. maydis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The Byr-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270792 [Multi-domain]  Cd Length: 286  Bit Score: 69.01  E-value: 2.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  801 TDLVG-FSYQVANGMDFLASK-NCVHRDLAARNVLICEGKLVKICDFGLARDIMRdsnyiSKGSTFLPLK-WMAPESIFN 877
Cdd:cd06620   103 EEVLGkIAVAVLEGLTYLYNVhRIIHRDIKPSNILVNSKGQIKLCDFGVSGELIN-----SIADTFVGTStYMSPERIQG 177
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 226342982  878 SLYTTLSDVWSFGILLWEIfTLGGTPYPELPMNDQFYNA 916
Cdd:cd06620   178 GKYSVKSDVWSLGLSIIEL-ALGEFPFAGSNDDDDGYNG 215
PKc_LIMK_like_unk cd14156
Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs ...
798-896 2.53e-12

Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This group is composed of uncharacterized proteins with similarity to LIMK and Testicular or testis-specific protein kinase (TESK). LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271058 [Multi-domain]  Cd Length: 256  Bit Score: 68.31  E-value: 2.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  798 LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLI---CEGKLVKICDFGLARDI--MRDSNYISK----GSTFlplk 868
Cdd:cd14156    86 LSWREKVELACDISRGMVYLHSKNIYHRDLNSKNCLIrvtPRGREAVVTDFGLAREVgeMPANDPERKlslvGSAF---- 161
                          90       100
                  ....*....|....*....|....*...
gi 226342982  869 WMAPESIFNSLYTTLSDVWSFGILLWEI 896
Cdd:cd14156   162 WMAPEMLRGEPYDRKVDVFSFGIVLCEI 189
STKc_CDK4 cd07863
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs ...
796-897 3.42e-12

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 partners with all three D-type cyclins (D1, D2, and D3) and is also regulated by INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein and plays a role in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the nucleus. CDK4 also shows kinase activity towards Smad3, a signal transducer of TGF-beta signaling which modulates transcription and plays a role in cell proliferation and apoptosis. CDK4 is inhibited by the p21 inhibitor and is specifically mutated in human melanoma. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143368 [Multi-domain]  Cd Length: 288  Bit Score: 68.45  E-value: 3.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  796 PVLSYTDLVgfsYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrdSNYISKGSTFLPLKWMAPESI 875
Cdd:cd07863   106 PAETIKDLM---RQFLRGLDFLHANCIVHRDLKPENILVTSGGQVKLADFGLARIY---SCQMALTPVVVTLWYRAPEVL 179
                          90       100
                  ....*....|....*....|..
gi 226342982  876 FNSLYTTLSDVWSFGILLWEIF 897
Cdd:cd07863   180 LQSTYATPVDMWSVGCIFAEMF 201
STKc_SLK cd06643
Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer ...
809-953 3.77e-12

Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It acts as a MAPK kinase kinase by phosphorylating ASK1, resulting in the phosphorylation of p38. SLK also plays a role in mediating actin reorganization. It is part of a microtubule-associated complex that is targeted at adhesion sites, and is required in focal adhesion turnover and in regulating cell migration. The SLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270811 [Multi-domain]  Cd Length: 283  Bit Score: 68.13  E-value: 3.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLA----RDIMRDSNYIskGSTFlplkWMAPESIF-----NSL 879
Cdd:cd06643   111 QTLEALVYLHENKIIHRDLKAGNILFTLDGDIKLADFGVSakntRTLQRRDSFI--GTPY----WMAPEVVMcetskDRP 184
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  880 YTTLSDVWSFGILLWEIFTLgGTPYPEL-PMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd06643   185 YDYKADVWSLGVTLIEMAQI-EPPHHELnPMRVLLKIAKSEPPTLAQPSRWSPEFKDFLRKCLEKNVDARWTTSQ 258
STKc_TEY_MAPK cd07858
Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; ...
806-903 3.93e-12

Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TEY subtype of plant MAPKs and is further subdivided into three groups (A, B, and C). Group A is represented by AtMPK3, AtMPK6, Nicotiana tabacum BTF4 (NtNTF4), among others. They are mostly involved in environmental and hormonal responses. AtMPK3 and AtMPK6 are also key regulators for stomatal development and patterning. Group B is represented by AtMPK4, AtMPK13, and NtNTF6, among others. They may be involved in both cell division and environmental stress response. AtMPK4 also participates in regulating innate immunity. Group C is represented by AtMPK1, AtMPK2, NtNTF3, Oryza sativa MAPK4 (OsMAPK4), among others. They may also be involved in stress responses. AtMPK1 and AtMPK2 are activated following mechanical injury and in the presence of stress chemicals such as jasmonic acid, hydrogen peroxide and abscisic acid. OsMAPK4 is also called OsMSRMK3 for Multiple Stress-Responsive MAPK3. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20. The TEY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143363 [Multi-domain]  Cd Length: 337  Bit Score: 68.94  E-value: 3.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYIskgSTFLPLKWM-APESIFN-SLYTTL 883
Cdd:cd07858   113 FLYQLLRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSEKGDFM---TEYVVTRWYrAPELLLNcSEYTTA 189
                          90       100
                  ....*....|....*....|
gi 226342982  884 SDVWSFGILLWEIftLGGTP 903
Cdd:cd07858   190 IDVWSVGCIFAEL--LGRKP 207
STKc_GSK3 cd14137
The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze ...
806-903 5.42e-12

The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GSK3 is a mutifunctional kinase involved in many cellular processes including cell division, proliferation, differentiation, adhesion, and apoptosis. In plants, GSK3 plays a role in the response to osmotic stress. In Caenorhabditis elegans, it plays a role in regulating normal oocyte-to-embryo transition and response to oxidative stress. In Chlamydomonas reinhardtii, GSK3 regulates flagellar length and assembly. In mammals, there are two isoforms, GSK3alpha and GSK3beta, which show both distinct and redundant functions. The two isoforms differ mainly in their N-termini. They are both involved in axon formation and in Wnt signaling.They play distinct roles in cardiogenesis, with GSKalpha being essential in cardiomyocyte survival, and GSKbeta regulating heart positioning and left-right symmetry. GSK3beta was first identified as a regulator of glycogen synthesis, but has since been determined to play other roles. It regulates the degradation of beta-catenin and IkB. Beta-catenin is the main effector of Wnt, which is involved in normal haematopoiesis and stem cell function. IkB is a central inhibitor of NF-kB, which is critical in maintaining leukemic cell growth. GSK3beta is enriched in the brain and is involved in regulating neuronal signaling pathways. It is implicated in the pathogenesis of many diseases including Type II diabetes, obesity, mood disorders, Alzheimer's disease, osteoporosis, and some types of cancer, among others. The GSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271039 [Multi-domain]  Cd Length: 293  Bit Score: 67.91  E-value: 5.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGK-LVKICDFGLARDIMRDSN---YISkgSTFlplkWMAPESIFNS-LY 880
Cdd:cd14137   111 YSYQLFRGLAYLHSLGICHRDIKPQNLLVDPETgVLKLCDFGSAKRLVPGEPnvsYIC--SRY----YRAPELIFGAtDY 184
                          90       100
                  ....*....|....*....|...
gi 226342982  881 TTLSDVWSFGILLWEIFTlgGTP 903
Cdd:cd14137   185 TTAIDIWSAGCVLAELLL--GQP 205
STKc_AMPK_alpha cd14079
Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein ...
601-939 5.72e-12

Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. In response to decreased ATP levels, it enhances energy-producing processes and inhibits energy-consuming pathways. Once activated, AMPK phosphorylates a broad range of downstream targets, with effects in carbohydrate metabolism and uptake, lipid and fatty acid biosynthesis, carbon energy storage, and inflammation, among others. Defects in energy homeostasis underlie many human diseases including Type 2 diabetes, obesity, heart disease, and cancer. As a result, AMPK has emerged as a therapeutic target in the treatment of these diseases. The AMPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270981 [Multi-domain]  Cd Length: 256  Bit Score: 67.29  E-value: 5.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  601 VLGRTLGSGAFGQVVEATahglsHSQATMKVAVKMLK----STARSSEKqaLMSELKIMsHLGPHLNVVNLLGACTKGGP 676
Cdd:cd14079     5 ILGKTLGVGSFGKVKLAE-----HELTGHKVAVKILNrqkiKSLDMEEK--IRREIQIL-KLFRHPHIIRLYEVIETPTD 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  677 IYIITEYCRYGDLVDYLHRNKHtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdMSKDESIDyvpmld 756
Cdd:cd14079    77 IFMVMEYVSGGELFDYIVQKGR--------------------------------------------LSEDEARR------ 106
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  757 mkgdikyadiespsymapydnyvpsapertyratlindspvlsytdlvgFSYQVANGMDFLASKNCVHRDLAARNVLICE 836
Cdd:cd14079   107 -------------------------------------------------FFQQIISGVEYCHRHMVVHRDLKPENLLLDS 137
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  837 GKLVKICDFGLArDIMRDSNYI--SKGStflPlKWMAPESIFNSLYT-TLSDVWSFGILLWEIftLGGTpypeLPMNDQF 913
Cdd:cd14079   138 NMNVKIADFGLS-NIMRDGEFLktSCGS---P-NYAAPEVISGKLYAgPEVDVWSCGVILYAL--LCGS----LPFDDEH 206
                         330       340       350
                  ....*....|....*....|....*....|
gi 226342982  914 ----YNAIKRGYRMAqPAHASDEIYEIMQK 939
Cdd:cd14079   207 ipnlFKKIKSGIYTI-PSHLSPGARDLIKR 235
STKc_ULK1_2-like cd14120
Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar ...
606-914 6.98e-12

Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. ULK2 is ubiquitously expressed and is essential in autophagy induction. ULK1 and ULK2 have unique and cell-type specific roles, but also display partially redundant roles in starvation-induced autophagy. They both display neuron-specific functions: ULK1 is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, and axon branching; ULK2 plays a role in axon development. The ULK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271022 [Multi-domain]  Cd Length: 256  Bit Score: 67.01  E-value: 6.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVEatahGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITEYCR 685
Cdd:cd14120     1 IGHGAFAVVFK----GRHRKKPDLPVAIKCITKKNLSKSQNLLGKEIKILKELS-HENVVALLDCQETSSSVYLVMEYCN 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  686 YGDLVDYLHRnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmKGDIkyad 765
Cdd:cd14120    76 GGDLADYLQA--------------------------------------------------------------KGTL---- 89
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  766 iespsymapydnyvpsaPERTYRATLIndspvlsytdlvgfsyQVANGMDFLASKNCVHRDLAARNVLICEGK------- 838
Cdd:cd14120    90 -----------------SEDTIRVFLQ----------------QIAAAMKALHSKGIVHRDLKPQNILLSHNSgrkpspn 136
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  839 --LVKICDFGLAR---DIMRDSNYIskGStflPLkWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPY-----PELp 908
Cdd:cd14120   137 diRLKIADFGFARflqDGMMAATLC--GS---PM-YMAPEVIMSLQYDAKADLWSIGTIVYQCLT-GKAPFqaqtpQEL- 208

                  ....*.
gi 226342982  909 mnDQFY 914
Cdd:cd14120   209 --KAFY 212
STKc_TSSK4-like cd14162
Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs ...
602-939 9.05e-12

Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. It phosphorylates Cre-Responsive Element Binding protein (CREB), facilitating the binding of CREB to the specific cis cAMP responsive element (CRE), which is important in activating genes related to germ cell differentiation. Mutations in the human TSSK4 gene is associated with infertile Chinese men with impaired spermatogenesis. The TSSK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271064 [Multi-domain]  Cd Length: 259  Bit Score: 66.55  E-value: 9.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  602 LGRTLGSGAFGQVVEATAHGLSHsqatmKVAVKMLkstarsSEKQA--------LMSELKIMSHLgPHLNVVNLLGACTK 673
Cdd:cd14162     4 VGKTLGHGSYAVVKKAYSTKHKC-----KVAIKIV------SKKKApedylqkfLPREIEVIKGL-KHPNLICFYEAIET 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  674 GGPIYIITEYCRYGDLVDYLHRNKHtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvp 753
Cdd:cd14162    72 TSRVYIIMELAENGDLLDYIRKNGA------------------------------------------------------- 96
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  754 mldmkgdikyadiespsymapydnyVPSAPERTYratlindspvlsytdlvgFSyQVANGMDFLASKNCVHRDLAARNVL 833
Cdd:cd14162    97 -------------------------LPEPQARRW------------------FR-QLVAGVEYCHSKGVVHRDLKCENLL 132
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  834 ICEGKLVKICDFGLARDIMRDSNYISKGS-TFLPLKWMAPESIFNSL-YT-TLSDVWSFGILLweiFTLggtPYPELPMN 910
Cdd:cd14162   133 LDKNNNLKITDFGFARGVMKTKDGKPKLSeTYCGSYAYASPEILRGIpYDpFLSDIWSMGVVL---YTM---VYGRLPFD 206
                         330       340       350
                  ....*....|....*....|....*....|...
gi 226342982  911 DQFY----NAIKRGYRMAQPAHASDEIYEIMQK 939
Cdd:cd14162   207 DSNLkvllKQVQRRVVFPKNPTVSEECKDLILR 239
STKc_MAP4K3_like cd06613
Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like ...
813-895 1.03e-11

Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAP4K3, MAP4K1, MAP4K2, MAP4K5, and related proteins. Vertebrate members contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K1, also called haematopoietic progenitor kinase 1 (HPK1), is a hematopoietic-specific STK involved in many cellular signaling cascades including MAPK, antigen receptor, apoptosis, growth factor, and cytokine signaling. It participates in the regulation of T cell receptor signaling and T cell-mediated immune responses. MAP4K2 was referred to as germinal center (GC) kinase because of its preferred location in GC B cells. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. It is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). The MAP4K3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270788 [Multi-domain]  Cd Length: 259  Bit Score: 66.56  E-value: 1.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  813 GMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrdSNYISKGSTFL--PLkWMAPESIF---NSLYTTLSDVW 887
Cdd:cd06613   109 GLAYLHSTGKIHRDIKGANILLTEDGDVKLADFGVSAQL---TATIAKRKSFIgtPY-WMAPEVAAverKGGYDGKCDIW 184

                  ....*...
gi 226342982  888 SFGILLWE 895
Cdd:cd06613   185 ALGITAIE 192
STKc_OSR1_SPAK cd06610
Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and ...
809-908 1.04e-11

Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SPAK is also referred to as STK39 or PASK (proline-alanine-rich STE20-related kinase). OSR1 and SPAK regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. They are also implicated in cytoskeletal rearrangement, cell differentiation, transformation and proliferation. OSR1 and SPAK contain a conserved C-terminal (CCT) domain, which recognizes a unique motif ([RK]FX[VI]) present in their activating kinases (WNK1/WNK4) and their substrates. The OSR1 and SPAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270787 [Multi-domain]  Cd Length: 267  Bit Score: 66.61  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKG-STFL--PLkWMAPESIFNSL-YTTLS 884
Cdd:cd06610   110 EVLKGLEYLHSNGQIHRDVKAGNILLGEDGSVKIADFGVSASLATGGDRTRKVrKTFVgtPC-WMAPEVMEQVRgYDFKA 188
                          90       100
                  ....*....|....*....|....
gi 226342982  885 DVWSFGILLWEIFTlGGTPYPELP 908
Cdd:cd06610   189 DIWSFGITAIELAT-GAAPYSKYP 211
STKc_STK25 cd06642
Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); ...
780-949 1.26e-11

Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK25 is also called Ste20/oxidant stress response kinase 1 (SOK1) or yeast Sps1/Ste20-related kinase 1 (YSK1). It is localized in the Golgi apparatus through its interaction with the Golgi matrix protein GM130. It may be involved in the regulation of cell migration and polarization. STK25 binds and phosphorylates CCM3 (cerebral cavernous malformation 3), also called PCD10 (programmed cell death 10), and may play a role in apoptosis. Human STK25 is a candidate gene responsible for pseudopseudohypoparathyroidism (PPHP), a disease that shares features with the Albright hereditary osteodystrophy (AHO) phenotype. The STK25 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270810 [Multi-domain]  Cd Length: 277  Bit Score: 66.62  E-value: 1.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  780 PSAPERTYRATLINdspvlsytdlvgfsyQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrdSNYIS 859
Cdd:cd06642    95 PGPLEETYIATILR---------------EILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQL---TDTQI 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  860 KGSTFL--PLkWMAPESIFNSLYTTLSDVWSFGILLWEIfTLGGTPYPEL-PMNDQFYnaIKRGYRMAQPAHASDEIYEI 936
Cdd:cd06642   157 KRNTFVgtPF-WMAPEVIKQSAYDFKADIWSLGITAIEL-AKGEPPNSDLhPMRVLFL--IPKNSPPTLEGQHSKPFKEF 232
                         170
                  ....*....|...
gi 226342982  937 MQKCWEEKFETRP 949
Cdd:cd06642   233 VEACLNKDPRFRP 245
STKc_MAK_like cd07830
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs ...
808-899 1.52e-11

Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of human MAK and MAK-related kinase (MRK), Saccharomyces cerevisiae Ime2p, Schizosaccharomyces pombe Mei4-dependent protein 3 (Mde3) and Pit1, Caenorhabditis elegans dyf-5, Arabidopsis thaliana MHK, and similar proteins. These proteins play important roles during meiosis. MAK is highly expressed in testicular cells specifically in the meiotic phase, but is not essential for spermatogenesis and fertility. It functions as a coactivator of the androgen receptor in prostate cells. MRK, also called Intestinal Cell Kinase (ICK), is expressed ubiquitously, with highest expression in the ovary and uterus. A missense mutation in MRK causes endocrine-cerebro-osteodysplasia, suggesting that this protein plays an important role in the development of many organs. MAK and MRK may be involved in regulating cell cycle and cell fate. Ime2p is a meiosis-specific kinase that is important during meiotic initiation and during the later stages of meiosis. Mde3 functions downstream of the transcription factor Mei-4 which is essential for meiotic prophase I. The MAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270824 [Multi-domain]  Cd Length: 283  Bit Score: 66.40  E-value: 1.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImRDS----NYIskgSTflplKWM-APESIFNS-LYT 881
Cdd:cd07830   106 YQILQGLAHIHKHGFFHRDLKPENLLVSGPEVVKIADFGLAREI-RSRppytDYV---ST----RWYrAPEILLRStSYS 177
                          90
                  ....*....|....*...
gi 226342982  882 TLSDVWSFGILLWEIFTL 899
Cdd:cd07830   178 SPVDIWALGCIMAELYTL 195
STKc_Nek4 cd08223
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
809-953 1.65e-11

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek4 is highly abundant in the testis. Its specific function is unknown. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. Nek4 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270862 [Multi-domain]  Cd Length: 257  Bit Score: 65.92  E-value: 1.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdIMRDSNYISKGSTFLPLkWMAPESIFNSLYTTLSDVWS 888
Cdd:cd08223   110 QIAMALQYMHERNILHRDLKTQNIFLTKSNIIKVGDLGIAR-VLESSSDMATTLIGTPY-YMSPELFSNKPYNHKSDVWA 187
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  889 FGILLWEIFTLGGTpYPELPMNDQFYNaIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd08223   188 LGCCVYEMATLKHA-FNAKDMNSLVYK-ILEGKLPPMPKQYSPELGELIKAMLHQDPEKRPSVKR 250
PKc_MKK5 cd06619
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
810-910 1.79e-11

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK5 (also called MEK5) is a dual-specificity PK that phosphorylates its downstream target, extracellular signal-regulated kinase 5 (ERK5), on specific threonine and tyrosine residues. MKK5 is activated by MEKK2 and MEKK3 in response to mitogenic and stress stimuli. The ERK5 cascade promotes cell proliferation, differentiation, neuronal survival, and neuroprotection. This cascade plays an essential role in heart development. Mice deficient in either ERK5 or MKK5 die around embryonic day 10 due to cardiovascular defects including underdevelopment of the myocardium. In addition, MKK5 is associated with metastasis and unfavorable prognosis in prostate cancer. The MKK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132950 [Multi-domain]  Cd Length: 279  Bit Score: 66.06  E-value: 1.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMrdsNYISKgsTFLPLK-WMAPESIFNSLYTTLSDVWS 888
Cdd:cd06619   104 VVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLV---NSIAK--TYVGTNaYMAPERISGEQYGIHSDVWS 178
                          90       100
                  ....*....|....*....|..
gi 226342982  889 FGILLWEIfTLGGTPYPELPMN 910
Cdd:cd06619   179 LGISFMEL-ALGRFPYPQIQKN 199
STKc_MAPK cd07834
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs ...
806-898 1.93e-11

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Typical MAPK pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPK kinase (MAP2K or MKK), which itself is phosphorylated and activated by a MAPK kinase kinase (MAP3K or MKKK). Each cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. There are three typical MAPK subfamilies: Extracellular signal-Regulated Kinase (ERK), c-Jun N-terminal Kinase (JNK), and p38. Some MAPKs are atypical in that they are not regulated by MAP2Ks. These include MAPK4, MAPK6, NLK, and ERK7. The MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270828 [Multi-domain]  Cd Length: 329  Bit Score: 66.78  E-value: 1.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLI---CEgklVKICDFGLARDIMRDSNYISKgSTFLPLKWM-APESIFNSL-Y 880
Cdd:cd07834   108 FLYQILRGLKYLHSAGVIHRDLKPSNILVnsnCD---LKICDFGLARGVDPDEDKGFL-TEYVVTRWYrAPELLLSSKkY 183
                          90
                  ....*....|....*...
gi 226342982  881 TTLSDVWSFGILLWEIFT 898
Cdd:cd07834   184 TKAIDIWSVGCIFAELLT 201
PKc_TOPK cd14001
Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer ...
807-977 1.93e-11

Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TOPK, also called PDZ-binding kinase (PBK), is activated at the early stage of mitosis and plays a critical role in cytokinesis. It partly functions as a mitogen-activated protein kinase (MAPK) kinase and is capable of phosphorylating p38, JNK1, and ERK2. TOPK also plays a role in DNA damage sensing and repair through its phosphorylation of histone H2AX. It contributes to cancer development and progression by downregulating the function of tumor suppressor p53 and reducing cell-cycle regulatory proteins. TOPK is found highly expressed in breast and skin cancer cells. The TOPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270903 [Multi-domain]  Cd Length: 292  Bit Score: 66.27  E-value: 1.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  807 SYQVANGMDFLAS-KNCVHRDLAARNVLIcEG--KLVKICDFG----LARDIMRDSN----YISKGStflplkWMAPESI 875
Cdd:cd14001   116 ALSIARALEYLHNeKKILHGDIKSGNVLI-KGdfESVKLCDFGvslpLTENLEVDSDpkaqYVGTEP------WKAKEAL 188
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  876 F-NSLYTTLSDVWSFGILLWEIFTLgGTPYPELPMNDQFYNaikrgyrmaqpahasDEIYEIMQKCWEEKFETRPPfsql 954
Cdd:cd14001   189 EeGGVITDKADIFAYGLVLWEMMTL-SVPHLNLLDIEDDDE---------------DESFDEDEEDEEAYYGTLGT---- 248
                         170       180
                  ....*....|....*....|...
gi 226342982  955 vllLERLLGEGYKKKYQQVDEEF 977
Cdd:cd14001   249 ---RPALNLGELDDSYQKVIELF 268
STKc_nPKC_theta_like cd05592
Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and ...
813-904 2.43e-11

Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. There are four nPKC isoforms, delta, epsilon, eta, and theta. The nPKC-theta-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270744 [Multi-domain]  Cd Length: 320  Bit Score: 66.25  E-value: 2.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  813 GMDFLASKNCVHRDLAARNVLI-CEGKlVKICDFGLARDIMRDSNyisKGSTF--LPlKWMAPESIFNSLYTTLSDVWSF 889
Cdd:cd05592   108 GLQFLHSRGIIYRDLKLDNVLLdREGH-IKIADFGMCKENIYGEN---KASTFcgTP-DYIAPEILKGQKYNQSVDWWSF 182
                          90
                  ....*....|....*
gi 226342982  890 GILLWEIFtLGGTPY 904
Cdd:cd05592   183 GVLLYEML-IGQSPF 196
PKc_Wee1_like cd13997
Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the ...
604-949 2.52e-11

Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity kinase Myt1, the protein tyrosine kinase Wee1, and similar proteins. These proteins are cell cycle checkpoint kinases that are involved in the regulation of cyclin-dependent kinase CDK1, the master engine for mitosis. CDK1 is kept inactivated through phosphorylation of N-terminal thr (T14 by Myt1) and tyr (Y15 by Myt1 and Wee1) residues. Mitosis progression is ensured through activation of CDK1 by dephoshorylation and inactivation of Myt1/Wee1. The Wee1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270899 [Multi-domain]  Cd Length: 252  Bit Score: 65.10  E-value: 2.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQV--VEATAHGLSHsqatmkvAVKMLKSTAR-SSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYII 680
Cdd:cd13997     6 EQIGSGSFSEVfkVRSKVDGCLY-------AVKKSKKPFRgPKERARALREVEAHAALGQHPNIVRYYSSWEEGGHLYIQ 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  681 TEYCRYGDLVDYLHRNkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgd 760
Cdd:cd13997    79 MELCENGSLQDALEEL---------------------------------------------------------------- 94
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  761 ikyadiespsymaPYDNYVPSApertyratlindspvlsytDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLV 840
Cdd:cd13997    95 -------------SPISKLSEA-------------------EVWDLLLQVALGLAFIHSKGIVHLDIKPDNIFISNKGTC 142
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  841 KICDFGLArdimrdsnyiSKGSTFLPL-----KWMAPESIFNSL-YTTLSDVWSFGILLWEIFTlgGTPypeLPMNDQFY 914
Cdd:cd13997   143 KIGDFGLA----------TRLETSGDVeegdsRYLAPELLNENYtHLPKADIFSLGVTVYEAAT--GEP---LPRNGQQW 207
                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 226342982  915 NAIKRGY--RMAQPAHaSDEIYEIMQKCWEEKFETRP 949
Cdd:cd13997   208 QQLRQGKlpLPPGLVL-SQELTRLLKVMLDPDPTRRP 243
STKc_Chk1 cd14069
Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the ...
599-914 2.82e-11

Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chk1 is implicated in many major checkpoints of the cell cycle, providing a link between upstream sensors and the cell cycle engine. It plays an important role in DNA damage response and maintaining genomic stability. Chk1 acts as an effector of the sensor kinase, ATR (ATM and Rad3-related), a member of the PI3K family, which is activated upon DNA replication stress. Chk1 delays mitotic entry in response to replication blocks by inhibiting cyclin dependent kinase (Cdk) activity. In addition, Chk1 contributes to the function of centrosome and spindle-based checkpoints, inhibits firing of origins of DNA replication (Ori), and represses transcription of cell cycle proteins including cyclin B and Cdk1. The Chk1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270971 [Multi-domain]  Cd Length: 261  Bit Score: 65.04  E-value: 2.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  599 QLVLGRTLGSGAFGQVVeatahgLSHSQAT-MKVAVKML-KSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGP 676
Cdd:cd14069     2 DWDLVQTLGEGAFGEVF------LAVNRNTeEAVAVKFVdMKRAPGDCPENIKKEVCIQKMLS-HKNVVRFYGHRREGEF 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  677 IYIITEYCRYGDLVDYLhrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgESDGGymdMSKDESidyvpmld 756
Cdd:cd14069    75 QYLFLEYASGGELFDKI-----------------------------------------EPDVG---MPEDVA-------- 102
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  757 mkgdikyadiespsymapydnyvpsapertyratlindspvlsytdlVGFSYQVANGMDFLASKNCVHRDLAARNVLICE 836
Cdd:cd14069   103 -----------------------------------------------QFYFQQLMAGLKYLHSCGITHRDIKPENLLLDE 135
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  837 GKLVKICDFGLArdimrdSNYISKGSTFL------PLKWMAPESIFNSLY-TTLSDVWSFGILLWEIFTlGGTPYPELPM 909
Cdd:cd14069   136 NDNLKISDFGLA------TVFRYKGKERLlnkmcgTLPYVAPELLAKKKYrAEPVDVWSCGIVLFAMLA-GELPWDQPSD 208

                  ....*
gi 226342982  910 NDQFY 914
Cdd:cd14069   209 SCQEY 213
PTKc_Wee1_fungi cd14052
Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the ...
605-896 3.31e-11

Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of fungal Wee1 proteins, also called Swe1 in budding yeast and Mik1 in fission yeast. Yeast Wee1 is required to control cell size. Wee1 is a cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. The fungal Wee1 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270954 [Multi-domain]  Cd Length: 278  Bit Score: 65.14  E-value: 3.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  605 TLGSGAFGQVVEATahglSHSQATMKVAVKMLK-STARSSEKQALMSELKIMSHL--GPHLNVVNLLGACTKGGPIYIIT 681
Cdd:cd14052     7 LIGSGEFSQVYKVS----ERVPTGKVYAVKKLKpNYAGAKDRLRRLEEVSILRELtlDGHDNIVQLIDSWEYHGHLYIQT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  682 EYCRYGDLVDYLhrnkhtflqrhsnkhcppsAELysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkGDI 761
Cdd:cd14052    83 ELCENGSLDVFL-------------------SEL-------------------------------------------GLL 100
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  762 KYADiespsymapydnyvpsaPERTYRATLindspvlsytdlvgfsyQVANGMDFLASKNCVHRDLAARNVLICEGKLVK 841
Cdd:cd14052   101 GRLD-----------------EFRVWKILV-----------------ELSLGLRFIHDHHFVHLDLKPANVLITFEGTLK 146
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982  842 ICDFGLA------RDIMR--DSNYIskgstflplkwmAPESIFNSLYTTLSDVWSFGILLWEI 896
Cdd:cd14052   147 IGDFGMAtvwpliRGIERegDREYI------------APEILSEHMYDKPADIFSLGLILLEA 197
STKc_PDK1 cd05581
Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs ...
598-933 3.97e-11

Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDK1 carries an N-terminal catalytic domain and a C-terminal pleckstrin homology (PH) domain that binds phosphoinositides. It phosphorylates the activation loop of AGC kinases that are regulated by PI3K such as PKB, SGK, and PKC, among others, and is crucial for their activation. Thus, it contributes in regulating many processes including metabolism, growth, proliferation, and survival. PDK1 also has the ability to autophosphorylate and is constitutively active in mammalian cells. It is essential for normal embryo development and is important in regulating cell volume. The PDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270733 [Multi-domain]  Cd Length: 278  Bit Score: 64.93  E-value: 3.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  598 DQLVLGRTLGSGAFGQVVEATAHglsHSQATmkVAVKMLkstarssEKQALMSELK---------IMSHLGpHLNVVNLL 668
Cdd:cd05581     1 NDFKFGKPLGEGSYSTVVLAKEK---ETGKE--YAIKVL-------DKRHIIKEKKvkyvtiekeVLSRLA-HPGIVKLY 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  669 GACTKGGPIYIITEYCRYGDLVDYLHRNKHtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdes 748
Cdd:cd05581    68 YTFQDESKLYFVLEYAPNGDLLEYIRKYGS-------------------------------------------------- 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  749 idyvpmLDMKgDIKYadiespsYMApydnyvpsapertyratlindspvlsytdlvgfsyQVANGMDFLASKNCVHRDLA 828
Cdd:cd05581    98 ------LDEK-CTRF-------YTA-----------------------------------EIVLALEYLHSKGIIHRDLK 128
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  829 ARNVLICEGKLVKICDFGLARDIMRDSNYIS-KGSTFLPLKWM--------------APESIFNSLYTTLSDVWSFGILL 893
Cdd:cd05581   129 PENILLDEDMHIKITDFGTAKVLGPDSSPEStKGDADSQIAYNqaraasfvgtaeyvSPELLNEKPAGKSSDLWALGCII 208
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 226342982  894 WEIFTlgGTPypelPMNDQ-----FYNAIKRGYRMAQ--PAHASDEI 933
Cdd:cd05581   209 YQMLT--GKP----PFRGSneyltFQKIVKLEYEFPEnfPPDAKDLI 249
STKc_CDK9_like cd07840
Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs ...
805-898 4.59e-11

Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes, yeast BUR1, C-type plant CDKs (CdkC), and similar proteins. CDK9, BUR1, and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain, which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2, and participates in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270832 [Multi-domain]  Cd Length: 291  Bit Score: 64.89  E-value: 4.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  805 GFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSN--YISKGSTflpLKWMAPESIFNS-LYT 881
Cdd:cd07840   108 CYMKQLLEGLQYLHSNGILHRDIKGSNILINNDGVLKLADFGLARPYTKENNadYTNRVIT---LWYRPPELLLGAtRYG 184
                          90
                  ....*....|....*..
gi 226342982  882 TLSDVWSFGILLWEIFT 898
Cdd:cd07840   185 PEVDMWSVGCILAELFT 201
STKc_MST4 cd06640
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs ...
809-896 5.78e-11

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST4 is sometimes referred to as MASK (MST3 and SOK1-related kinase). It plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. It influences cell growth and transformation by modulating the extracellular signal-regulated kinase (ERK) pathway. MST4 may also play a role in tumor formation and progression. It localizes in the Golgi apparatus by interacting with the Golgi matrix protein GM130 and may play a role in cell migration. The MST4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132971 [Multi-domain]  Cd Length: 277  Bit Score: 64.69  E-value: 5.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrdSNYISKGSTFL--PLkWMAPESIFNSLYTTLSDV 886
Cdd:cd06640   109 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQL---TDTQIKRNTFVgtPF-WMAPEVIQQSAYDSKADI 184
                          90
                  ....*....|
gi 226342982  887 WSFGILLWEI 896
Cdd:cd06640   185 WSLGITAIEL 194
STKc_Yank1 cd05578
Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the ...
810-905 5.80e-11

Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily contains uncharacterized STKs with similarity to the human protein designated as Yank1 or STK32A. The Yank1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270730 [Multi-domain]  Cd Length: 257  Bit Score: 64.20  E-value: 5.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTflpLKWMAPESIFNSLYTTLSDVWSF 889
Cdd:cd05578   109 IVLALDYLHSKNIIHRDIKPDNILLDEQGHVHITDFNIATKLTDGTLATSTSGT---KPYMAPEVFMRAGYSFAVDWWSL 185
                          90
                  ....*....|....*.
gi 226342982  890 GILLWEiFTLGGTPYP 905
Cdd:cd05578   186 GVTAYE-MLRGKRPYE 200
PKc_MAPKK cd06605
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase ...
809-917 6.06e-11

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MAPKKs are dual-specificity PKs that phosphorylate their downstream targets, MAPKs, at specific threonine and tyrosine residues. The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising the MAPK, which is phosphorylated and activated by a MAPK kinase (MAPKK or MKK or MAP2K), which itself is phosphorylated and activated by a MAPKK kinase (MAPKKK or MKKK or MAP3K). There are three MAPK subfamilies: extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. In mammalian cells, there are seven MAPKKs (named MKK1-7) and 20 MAPKKKs. Each MAPK subfamily can be activated by at least two cognate MAPKKs and by multiple MAPKKKs. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270782 [Multi-domain]  Cd Length: 265  Bit Score: 64.29  E-value: 6.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASK-NCVHRDLAARNVLICEGKLVKICDFGLARDIMRdsnyiSKGSTFLPLK-WMAPESIFNSLYTTLSDV 886
Cdd:cd06605   107 AVVKGLIYLHEKhKIIHRDVKPSNILVNSRGQVKLCDFGVSGQLVD-----SLAKTFVGTRsYMAPERISGGKYTVKSDI 181
                          90       100       110
                  ....*....|....*....|....*....|.
gi 226342982  887 WSFGILLWEIfTLGGTPYPelPMNDQFYNAI 917
Cdd:cd06605   182 WSLGLSLVEL-ATGRFPYP--PPNAKPSMMI 209
STKc_TAO cd06607
Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs ...
813-949 6.49e-11

Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. They activate the MAPKs, p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating the respective MAP/ERK kinases (MEKs, also known as MKKs or MAPKKs), MEK3/MEK6 and MKK4/MKK7. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. Vertebrates contain three TAO subfamily members, named TAO1, TAO2, and TAO3. The TAO subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270784 [Multi-domain]  Cd Length: 258  Bit Score: 64.01  E-value: 6.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  813 GMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLArdimrdsNYISKGSTFL--PLkWMAPESIF---NSLYTTLSDVW 887
Cdd:cd06607   113 GLAYLHSHNRIHRDVKAGNILLTEPGTVKLADFGSA-------SLVCPANSFVgtPY-WMAPEVILamdEGQYDGKVDVW 184
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226342982  888 SFGILLWEiftLGGTPYPELPMndqfyNAIKRGYRMAQ-------PAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd06607   185 SLGITCIE---LAERKPPLFNM-----NAMSALYHIAQndsptlsSGEWSDDFRNFVDSCLQKIPQDRP 245
STKc_CDKL2_3 cd07846
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; ...
808-918 6.60e-11

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL2, also called p56 KKIAMRE, is expressed in testis, kidney, lung, and brain. It functions mainly in mature neurons and plays an important role in learning and memory. Inactivation of CDKL3, also called NKIAMRE (NKIATRE in rat), by translocation is associated with mild mental retardation. It has been reported that CDKL3 is lost in leukemic cells having a chromosome arm 5q deletion, and may contribute to the transformed phenotype. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270836 [Multi-domain]  Cd Length: 286  Bit Score: 64.37  E-value: 6.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKgstFLPLKWM-APESIF-NSLYTTLSD 885
Cdd:cd07846   107 FQILRGIDFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTD---YVATRWYrAPELLVgDTKYGKAVD 183
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 226342982  886 VWSFGILLWEIFTlgGTPYpeLPMN---DQFYNAIK 918
Cdd:cd07846   184 VWAVGCLVTEMLT--GEPL--FPGDsdiDQLYHIIK 215
STKc_HAL4_like cd13994
Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs ...
790-916 6.70e-11

Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of HAL4, Saccharomyces cerevisiae Ptk2/Stk2, and similar fungal proteins. Proteins in this subfamily are involved in regulating ion transporters. In budding and fission yeast, HAL4 promotes potassium ion uptake, which increases cellular resistance to other cations such as sodium, lithium, and calcium ions. HAL4 stabilizes the major high-affinity K+ transporter Trk1 at the plasma membrane under low K+ conditions, which prevents endocytosis and vacuolar degradation. Budding yeast Ptk2 phosphorylates and regulates the plasma membrane H+ ATPase, Pma1. The HAL4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270896 [Multi-domain]  Cd Length: 265  Bit Score: 64.25  E-value: 6.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  790 TLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISK------GSt 863
Cdd:cd13994    87 TLIEKADSLSLEEKDCFFKQILRGVAYLHSHGIAHRDLKPENILLDEDGVLKLTDFGTAEVFGMPAEKESPmsaglcGS- 165
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  864 fLPLkwMAPEsIFNSL-YT-TLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNA 916
Cdd:cd13994   166 -EPY--MAPE-VFTSGsYDgRAVDVWSCGIVLFALFT-GRFPWRSAKKSDSAYKA 215
STKc_ULK4 cd14010
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the ...
789-898 7.65e-11

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ULK4 is a functionally uncharacterized kinase that shows similarity to ATG1/ULKs. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. The ULK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270912 [Multi-domain]  Cd Length: 269  Bit Score: 63.85  E-value: 7.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  789 ATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLAR----------DIMRDSNYI 858
Cdd:cd14010    82 ETLLRQDGNLPESSVRKFGRDLVRGLHYIHSKGIIYCDLKPSNILLDGNGTLKLSDFGLARregeilkelfGQFSDEGNV 161
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 226342982  859 SKGSTFLPLK----WMAPESIFNSLYTTLSDVWSFGILLWEIFT 898
Cdd:cd14010   162 NKVSKKQAKRgtpyYMAPELFQGGVHSFASDLWALGCVLYEMFT 205
STKc_MAPK4_6 cd07854
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also ...
806-898 9.51e-11

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK4 (also called ERK4 or p63MAPK) and MAPK6 (also called ERK3 or p97MAPK) are atypical MAPKs that are not regulated by MAPK kinases. MAPK6 is expressed ubiquitously with highest amounts in brain and skeletal muscle. It may be involved in the control of cell differentiation by negatively regulating cell cycle progression in certain conditions. It may also play a role in glucose-induced insulin secretion. MAPK6 and MAPK4 cooperate to regulate the activity of MAPK-activated protein kinase 5 (MK5), leading to its relocation to the cytoplasm and exclusion from the nucleus. The MAPK6/MK5 and MAPK4/MK5 pathways may play critical roles in embryonic and post-natal development. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143359 [Multi-domain]  Cd Length: 342  Bit Score: 64.80  E-value: 9.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLV-KICDFGLARdIMrDSNYISKG--STFLPLKWM-APESIFN-SLY 880
Cdd:cd07854   119 FMYQLLRGLKYIHSANVLHRDLKPANVFINTEDLVlKIGDFGLAR-IV-DPHYSHKGylSEGLVTKWYrSPRLLLSpNNY 196
                          90
                  ....*....|....*...
gi 226342982  881 TTLSDVWSFGILLWEIFT 898
Cdd:cd07854   197 TKAIDMWAAGCIFAEMLT 214
STKc_TDY_MAPK cd07859
Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; ...
806-903 9.55e-11

Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TDY subtype and is composed of Group D plant MAPKs including Arabidopsis thaliana MPK18 (AtMPK18), Oryza sativa Blast- and Wound-induced MAPK1 (OsBWMK1), OsWJUMK1 (Wound- and JA-Uninducible MAPK1), Zea mays MPK6, and the Medicago sativa TDY1 gene product. OsBWMK1 enhances resistance to pathogenic infections. It mediates stress-activated defense responses by activating a transcription factor that affects the expression of stress-related genes. AtMPK18 is involved in microtubule-related functions. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20 while Oryza sativa contains at least 17 MAPKs. Arabidopsis thaliana contains more TEY-type MAPKs than TDY-type, whereas the reverse is true for Oryza sativa. The TDY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143364 [Multi-domain]  Cd Length: 338  Bit Score: 64.80  E-value: 9.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWM-APE--SIFNSLYTT 882
Cdd:cd07859   108 FLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGLARVAFNDTPTAIFWTDYVATRWYrAPElcGSFFSKYTP 187
                          90       100
                  ....*....|....*....|.
gi 226342982  883 LSDVWSFGILLWEIFTlgGTP 903
Cdd:cd07859   188 AIDIWSIGCIFAEVLT--GKP 206
STKc_IKK cd13989
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
810-898 1.15e-10

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The IKK complex functions as a master regulator of Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. It is composed of two kinases, IKKalpha and IKKbeta, and the regulatory subunit IKKgamma or NEMO (NF-kB Essential MOdulator). IKKs facilitate the release of NF-kB dimers from an inactive state, allowing them to migrate to the nucleus where they regulate gene transcription. There are two IKK pathways that regulate NF-kB signaling, called the classical (involving IKKbeta and NEMO) and non-canonical (involving IKKalpha) pathways. The classical pathway regulates the majority of genes activated by NF-kB. The IKK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270891 [Multi-domain]  Cd Length: 289  Bit Score: 63.62  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLI--CEGKLV-KICDFGLARDIMRDSNYISKGSTflpLKWMAPESIFNSLYTTLSDV 886
Cdd:cd13989   111 ISSAISYLHENRIIHRDLKPENIVLqqGGGRVIyKLIDLGYAKELDQGSLCTSFVGT---LQYLAPELFESKKYTCTVDY 187
                          90
                  ....*....|..
gi 226342982  887 WSFGILLWEIFT 898
Cdd:cd13989   188 WSFGTLAFECIT 199
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
36-113 1.29e-10

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 58.75  E-value: 1.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    36 PPGPEFVLNISSTFVLTCSGS-----APVMWEQMSQVP--WQEAAMNQDGTFSSVLTLTNVTGGDTGEYFCVYNNSLGPE 108
Cdd:pfam00047    1 SAPPTVTVLEGDSATLTCSAStgspgPDVTWSKEGGTLieSLKVKHDNGRTTQSSLLISNVTKEDAGTYTCVVNNPGGSA 80

                   ....*
gi 226342982   109 LSERK 113
Cdd:pfam00047   81 TLSTS 85
STKc_PLK cd14099
Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the ...
603-932 1.32e-10

Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. PLKs derive their names from homology to polo, a kinase first identified in Drosophila. There are five mammalian PLKs (PLK1-5) from distinct genes. There is good evidence that PLK1 may function as an oncogene while PLK2-5 have tumor suppressive properties. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. PLK2 functions in G1 progression, S-phase arrest, and centriole duplication. PLK3 regulates angiogenesis and responses to DNA damage. PLK4 is required for late mitotic progression, cell survival, and embryonic development. PLK5 was first identified as a pseudogene containing a stop codon within the kinase domain, however, both murine and human genes encode expressed proteins. PLK5 functions in cell cycle arrest.


Pssm-ID: 271001 [Multi-domain]  Cd Length: 258  Bit Score: 62.96  E-value: 1.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  603 GRTLGSGAFGQVVEATAHGLSHSQAtMKVAVKMLKSTARSSEKqaLMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITE 682
Cdd:cd14099     6 GKFLGKGGFAKCYEVTDMSTGKVYA-GKVVPKSSLTKPKQREK--LKSEIKIHRSLK-HPNIVKFHDCFEDEENVYILLE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  683 YCRYGDLVDYLHRNKhtflqrhsnkhcppsaelysnalpvGFSLPshlnltgesdggymdmskdesidyvpmldmkgDIK 762
Cdd:cd14099    82 LCSNGSLMELLKRRK-------------------------ALTEP--------------------------------EVR 104
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  763 YadiespsYMapydnyvpsapertyratlindspvlsytdlvgfsYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKI 842
Cdd:cd14099   105 Y-------FM-----------------------------------RQILSGVKYLHSNRIIHRDLKLGNLFLDENMNVKI 142
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  843 CDFGLARDIMRDS----------NYIskgstflplkwmAPESIFNSL-YTTLSDVWSFGILLweiFTL--GGTPYpELPM 909
Cdd:cd14099   143 GDFGLAARLEYDGerkktlcgtpNYI------------APEVLEKKKgHSFEVDIWSLGVIL---YTLlvGKPPF-ETSD 206
                         330       340
                  ....*....|....*....|....
gi 226342982  910 NDQFYNAIKRG-YRMAQPAHASDE 932
Cdd:cd14099   207 VKETYKRIKKNeYSFPSHLSISDE 230
STKc_Kin1_2 cd14077
Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the ...
806-939 1.39e-10

Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of yeast Kin1, Kin2, and similar proteins. Fission yeast Kin1 is a membrane-associated kinase that is involved in regulating cell surface cohesiveness during interphase. It also plays a role during mitosis, linking actomyosin ring assembly with septum synthesis and membrane closure to ensure separation of daughter cells. Budding yeast Kin1 and Kin2 act downstream of the Rab-GTPase Sec4 and are associated with the exocytic apparatus; they play roles in the secretory pathway. The Kin1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270979 [Multi-domain]  Cd Length: 267  Bit Score: 63.24  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLardimrdSNYISKGS---TFL-PLKWMAPESIFNSLYT 881
Cdd:cd14077   118 FARQIASALDYLHRNSIVHRDLKIENILISKSGNIKIIDFGL-------SNLYDPRRllrTFCgSLYFAAPELLQAQPYT 190
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 226342982  882 TLS-DVWSFGILLWeIFTLGGTPYPELPMNdQFYNAIKRGyRMAQPAHASDEIYEIMQK 939
Cdd:cd14077   191 GPEvDVWSFGVVLY-VLVCGKVPFDDENMP-ALHAKIKKG-KVEYPSYLSSECKSLISR 246
STKc_MAPK15-like cd07852
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and ...
808-903 1.56e-10

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human MAPK15 is also called Extracellular signal Regulated Kinase 8 (ERK8) while the rat protein is called ERK7. ERK7 and ERK8 display both similar and different biochemical properties. They autophosphorylate and activate themselves and do not require upstream activating kinases. ERK7 is constitutively active and is not affected by extracellular stimuli whereas ERK8 shows low basal activity and is activated by DNA-damaging agents. ERK7 and ERK8 also have different substrate profiles. Genome analysis shows that they are orthologs with similar gene structures. ERK7 and ERK 8 may be involved in the signaling of some nuclear receptor transcription factors. ERK7 regulates hormone-dependent degradation of estrogen receptor alpha while ERK8 down-regulates the transcriptional co-activation androgen and glucocorticoid receptors. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK15 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270841 [Multi-domain]  Cd Length: 337  Bit Score: 64.12  E-value: 1.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLI---CegkLVKICDFGLARDIMRDSNYISKG------STflplKWM-APESIFN 877
Cdd:cd07852   114 YQLLKALKYLHSGGVIHRDLKPSNILLnsdC---RVKLADFGLARSLSQLEEDDENPvltdyvAT----RWYrAPEILLG 186
                          90       100
                  ....*....|....*....|....*..
gi 226342982  878 S-LYTTLSDVWSFGILLWEIftLGGTP 903
Cdd:cd07852   187 StRYTKGVDMWSVGCILGEM--LLGKP 211
STKc_PKA_like cd05580
Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs ...
806-910 1.68e-10

Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the cAMP-dependent protein kinases, PKA and PRKX, and similar proteins. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. PRKX is also reulated by the R subunit and is is present in many tissues including fetal and adult brain, kidney, and lung. It is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PKA-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270732 [Multi-domain]  Cd Length: 290  Bit Score: 63.37  E-value: 1.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImRDSNYISKGStflPlKWMAPESIFNSLYTTLSD 885
Cdd:cd05580   106 YAAEVVLALEYLHSLDIVYRDLKPENLLLDSDGHIKITDFGFAKRV-KDRTYTLCGT---P-EYLAPEIILSKGHGKAVD 180
                          90       100
                  ....*....|....*....|....*..
gi 226342982  886 VWSFGILLWEIftLGGTP--YPELPMN 910
Cdd:cd05580   181 WWALGILIYEM--LAGYPpfFDENPMK 205
STKc_LRRK2 cd14068
Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2; STKs catalyze ...
782-953 1.88e-10

Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRK2 is one of two vertebrate LRRKs which show complementary expression in the brain. Mutations in LRRK2, found in the kinase, ROC-COR, and WD40 domains, are linked to both familial and sporadic forms of Parkinson's disease. The most prevalent mutation, G2019S located in the activation loop of the kinase domain, increases kinase activity. The R1441C/G mutations in the GTPase domain have also been reported to influence kinase activity. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. The LRRK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270970 [Multi-domain]  Cd Length: 252  Bit Score: 62.66  E-value: 1.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  782 APERTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGK-----LVKICDFGLARDIMRDSN 856
Cdd:cd14068    67 APKGSLDALLQQDNASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYpncaiIAKIADYGIAQYCCRMGI 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  857 YISKGSTflplKWMAPE-SIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYN-AIKRgyRMAQPAHASD--- 931
Cdd:cd14068   147 KTSEGTP----GFRAPEvARGNVIYNQQADVYSFGLLLYDILTCGERIVEGLKFPNEFDElAIQG--KLPDPVKEYGcap 220
                         170       180
                  ....*....|....*....|....
gi 226342982  932 --EIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14068   221 wpGVEALIKDCLKENPQCRPTSAQ 244
STKc_nPKC_theta cd05619
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze ...
806-904 2.00e-10

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. Although T-cells also express other PKC isoforms, PKC-theta is unique in that upon antigen stimulation, it is translocated to the plasma membrane at the immunological synapse, where it mediates signals essential for T-cell activation. It is essential for TCR-induced proliferation, cytokine production, T-cell survival, and the differentiation and effector function of T-helper (Th) cells, particularly Th2 and Th17. PKC-theta is being developed as a therapeutic target for Th2-mediated allergic inflammation and Th17-mediated autoimmune diseases. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270770 [Multi-domain]  Cd Length: 331  Bit Score: 63.40  E-value: 2.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyiSKGSTFLPL-KWMAPESIFNSLYTTLS 884
Cdd:cd05619   111 YAAEIICGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGD---AKTSTFCGTpDYIAPEILLGQKYNTSV 187
                          90       100
                  ....*....|....*....|
gi 226342982  885 DVWSFGILLWEIFtLGGTPY 904
Cdd:cd05619   188 DWWSFGVLLYEML-IGQSPF 206
STKc_MEKK3_like cd06625
Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) ...
806-949 2.14e-10

Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MEKK3, MEKK2, and related proteins; all contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKK) that activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270795 [Multi-domain]  Cd Length: 260  Bit Score: 62.37  E-value: 2.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI--MRDSNYIsKGSTFLPLkWMAPESIFNSLYTTL 883
Cdd:cd06625   107 YTRQILEGLAYLHSNMIVHRDIKGANILRDSNGNVKLGDFGASKRLqtICSSTGM-KSVTGTPY-WMSPEVINGEGYGRK 184
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  884 SDVWSFGILLWEIFTlGGTPYPEL-PMNDQFYNAIKR-GYRMaqPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd06625   185 ADIWSVGCTVVEMLT-TKPPWAEFePMAAIFKIATQPtNPQL--PPHVSEDARDFLSLIFVRNKKQRP 249
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
215-293 2.64e-10

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 57.58  E-value: 2.64e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226342982   215 VSVNAVQTVVRQGESITIRCIVMGNDVVNFQWTyprmKSGRLVEPVTDYLFGVpSRIGSILHIPTAELSDSGTYTCNVS 293
Cdd:pfam13927    4 ITVSPSSVTVREGETVTLTCEATGSPPPTITWY----KNGEPISSGSTRSRSL-SGSNSTLTISNVTRSDAGTYTCVAS 77
STKc_CDKL1_4 cd07847
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4; ...
808-918 2.65e-10

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL1, also called p42 KKIALRE, is a glial protein that is upregulated in gliosis. It is present in neuroblastoma and A431 human carcinoma cells, and may be implicated in neoplastic transformation. The function of CDKL4 is unknown. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL1/4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270837 [Multi-domain]  Cd Length: 286  Bit Score: 62.77  E-value: 2.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMR-DSNYISKGSTflplKWM-APESIFNSL-YTTLS 884
Cdd:cd07847   107 WQTLQAVNFCHKHNCIHRDVKPENILITKQGQIKLCDFGFARILTGpGDDYTDYVAT----RWYrAPELLVGDTqYGPPV 182
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 226342982  885 DVWSFGILLWEIFTlgGTP-YPELPMNDQFYNAIK 918
Cdd:cd07847   183 DVWAIGCVFAELLT--GQPlWPGKSDVDQLYLIRK 215
PTK_Jak2_rpt1 cd05078
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2; Jak2 is widely ...
807-951 2.75e-10

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2; Jak2 is widely expressed in many tissues. It is essential for the signaling of hormone-like cytokines such as growth hormone, erythropoietin, thrombopoietin, and prolactin, as well as some IFNs and cytokines that signal through the IL-3 and gp130 receptors. Disruption of Jak2 in mice results in an embryonic lethal phenotype with multiple defects including erythropoietic and cardiac abnormalities. It is the only Jak gene that results in a lethal phenotype when disrupted in mice. A mutation in the pseudokinase domain of Jak2, V617F, is present in many myeloproliferative diseases, including almost all patients with polycythemia vera, and 50% of patients with essential thrombocytosis and myelofibrosis. Jak2 is a cytoplasmic (or nonreceptor) PTK containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. Despite this, the presumed pseudokinase (repeat 1) domain of Jak2 exhibits dual-specificity kinase activity, phosphorylating two negative regulatory sites in Jak2: Ser523 and Tyr570. Inactivation of the repeat 1 domain increased Jak2 basal activity, suggesting that it modulates the kinase activity of the C-terminal catalytic (repeat 2) domain. The Jak2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270663 [Multi-domain]  Cd Length: 262  Bit Score: 62.27  E-value: 2.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  807 SYQVANGMDFLASKNCVHRDLAARNVLICEGK--------LVKICDFG-----LARDIMRDSnyiskgstflpLKWMAPE 873
Cdd:cd05078   110 AKQLAWAMHFLEEKTLVHGNVCAKNILLIREEdrktgnppFIKLSDPGisitvLPKDILLER-----------IPWVPPE 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  874 SIFNSLYTTL-SDVWSFGILLWEIFTLGGTPYPELPMND--QFYNAikrgyRMAQPAHASDEIYEIMQKCWEEKFETRPP 950
Cdd:cd05078   179 CIENPKNLSLaTDKWSFGTTLWEICSGGDKPLSALDSQRklQFYED-----RHQLPAPKWTELANLINNCMDYEPDHRPS 253

                  .
gi 226342982  951 F 951
Cdd:cd05078   254 F 254
PLN00034 PLN00034
mitogen-activated protein kinase kinase; Provisional
790-1001 2.93e-10

mitogen-activated protein kinase kinase; Provisional


Pssm-ID: 215036 [Multi-domain]  Cd Length: 353  Bit Score: 63.30  E-value: 2.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  790 TLINDSPVLSytDLvgfSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLAR---DIMRDSNyiskgSTFLP 866
Cdd:PLN00034  162 THIADEQFLA--DV---ARQILSGIAYLHRRHIVHRDIKPSNLLINSAKNVKIADFGVSRilaQTMDPCN-----SSVGT 231
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  867 LKWMAPESIFNSLYTTL-----SDVWSFGILLWEiFTLGGTPYPELPMNDqfYNAIKRGYRMAQ----PAHASDEIYEIM 937
Cdd:PLN00034  232 IAYMSPERINTDLNHGAydgyaGDIWSLGVSILE-FYLGRFPFGVGRQGD--WASLMCAICMSQppeaPATASREFRHFI 308
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  938 QKCWEEKFETRPPFSQLVlllerllgegykkkyqqvdeeflrsDHPAILRSQARF----PGIHSLRSP 1001
Cdd:PLN00034  309 SCCLQREPAKRWSAMQLL-------------------------QHPFILRAQPGQgqggPNLHQLLPP 351
STKc_cPKC_beta cd05616
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs ...
804-936 3.01e-10

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PKC beta isoforms (I and II), generated by alternative splicing of a single gene, are preferentially activated by hyperglycemia-induced DAG (1,2-diacylglycerol) in retinal tissues. This is implicated in diabetic microangiopathy such as ischemia, neovascularization, and abnormal vasodilator function. PKC-beta also plays an important role in VEGF signaling. In addition, glucose regulates proliferation in retinal endothelial cells via PKC-betaI. PKC-beta is also being explored as a therapeutic target in cancer. It contributes to tumor formation and is involved in the tumor host mechanisms of inflammation and angiogenesis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG, and in most cases, phosphatidylserine (PS) for activation. The cPKC-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270767 [Multi-domain]  Cd Length: 323  Bit Score: 63.09  E-value: 3.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  804 VGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnYISKGSTFLPlKWMAPESIFNSLYTTL 883
Cdd:cd05616   104 VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG-VTTKTFCGTP-DYIAPEIIAYQPYGKS 181
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 226342982  884 SDVWSFGILLWEIftLGGTPYPELPMNDQFYNAIKRgYRMAQPAHASDEIYEI 936
Cdd:cd05616   182 VDWWAFGVLLYEM--LAGQAPFEGEDEDELFQSIME-HNVAYPKSMSKEAVAI 231
STKc_PAK_I cd06647
Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze ...
809-948 3.14e-10

Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group I PAKs, also called conventional PAKs, include PAK1, PAK2, and PAK3. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). They interact with the SH3 domain containing proteins Nck, Grb2 and PIX. Binding of group I PAKs to activated GTPases leads to conformational changes that destabilize the AID, allowing autophosphorylation and full activation of the kinase domain. Known group I PAK substrates include MLCK, Bad, Raf, MEK1, LIMK, Merlin, Vimentin, Myc, Stat5a, and Aurora A, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270814 [Multi-domain]  Cd Length: 261  Bit Score: 62.25  E-value: 3.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyiSKGSTFLPLK-WMAPESIFNSLYTTLSDVW 887
Cdd:cd06647   111 ECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ---SKRSTMVGTPyWMAPEVVTRKAYGPKVDIW 187
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  888 SFGILLWEIFTlGGTPY-PELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETR 948
Cdd:cd06647   188 SLGIMAIEMVE-GEPPYlNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKR 248
STKc_PAK3 cd06656
Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine ...
813-948 3.35e-10

Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine/threonine kinases (STKs), p21-activated kinase (PAK) 3, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. PAK3 belongs to group I. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAK3 is highly expressed in the brain. It is implicated in neuronal plasticity, synapse formation, dendritic spine morphogenesis, cell cycle progression, neuronal migration, and apoptosis. Inactivating mutations in the PAK3 gene cause X-linked non-syndromic mental retardation, the severity of which depends on the site of the mutation.


Pssm-ID: 132987 [Multi-domain]  Cd Length: 297  Bit Score: 62.43  E-value: 3.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  813 GMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyiSKGSTFLPLK-WMAPESIFNSLYTTLSDVWSFGI 891
Cdd:cd06656   127 ALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ---SKRSTMVGTPyWMAPEVVTRKAYGPKVDIWSLGI 203
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  892 LLWEIFTlGGTPY-PELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETR 948
Cdd:cd06656   204 MAIEMVE-GEPPYlNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRR 260
PK_GC-C cd14044
Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C; The pseudokinase domain ...
741-953 3.67e-10

Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity and/or ATP binding. GC-C binds and is activated by the intestinal hormones, guanylin (GN) and uroguanylin (UGN), which are secreted after salty meals to inhibit sodium absorption and induce the secretion of chloride, bicarbonate, and water. GN and UGN are also present in the kidney, where they induce increased salt and water secretion. This prevents the development of hypernatremia and hypervolemia after ingestion of high amounts of salt. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC-C subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270946 [Multi-domain]  Cd Length: 271  Bit Score: 62.21  E-value: 3.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  741 MDMSKDESIDYVPMLDMKGDIKYadiespsymapyDNYVPSAPERTYRATL---INDS---PVLSYTDL---VGFSYQVA 811
Cdd:cd14044    52 IELNKLLQIDYYNLTKFYGTVKL------------DTMIFGVIEYCERGSLrdvLNDKisyPDGTFMDWefkISVMYDIA 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  812 NGMDFLASKNC-VHRDLAARNVLICEGKLVKICDFGlARDIMRDSNYIskgstflplkWMAPESIFNSLYTTLSDVWSFG 890
Cdd:cd14044   120 KGMSYLHSSKTeVHGRLKSTNCVVDSRMVVKITDFG-CNSILPPSKDL----------WTAPEHLRQAGTSQKGDVYSYG 188
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  891 ILLWEIFTLGGTPYPElpmndQFYNAIKRGYRMAQPAHASD---------------EIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14044   189 IIAQEIILRKETFYTA-----ACSDRKEKIYRVQNPKGMKPfrpdlnlesagererEVYGLVKNCWEEDPEKRPDFKK 261
PK_SCY1_like cd14011
Pseudokinase domain of Scy1-like proteins; The pseudokinase domain shows similarity to protein ...
808-904 3.85e-10

Pseudokinase domain of Scy1-like proteins; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. This subfamily is composed of the catalytically inactive kinases with similarity to yeast Scy1. It includes four mammalian proteins called SCY1-like protein 1 (SCYL1), SCYL2, SCYL3, as well as Testis-EXpressed protein 14 (TEX14). SCYL1 binds to and co-localizes with the membrane trafficking coatomer I (COPI) complex, and regulates COPI-mediated vesicle trafficking. Null mutations in the SCYL1 gene are responsible for the pathology in mdf (muscle-deficient) mice which display progressive motor neuropathy. SCYL2, also called coated vesicle-associated kinase of 104 kDa (CVAK104), is involved in the trafficking of clathrin-coated vesicles. It also binds the HIV-1 accessory protein Vpu and acts as a regulatory factor that promotes the dephosphorylation of Vpu, facilitating the restriction of HIV-1 release. SCYL3, also called ezrin-binding protein PACE-1, may be involved in regulating cell adhesion and migration. TEX14 is required for spermatogenesis and male fertility. It localizes to kinetochores (KT) during mitosis and is a target of the mitotic kinase PLK1. It regulates the maturation of the outer KT and the KT-microtubule attachment. The SCY1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270913 [Multi-domain]  Cd Length: 287  Bit Score: 62.34  E-value: 3.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFL-ASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTF---------LPLKWMAPESIFN 877
Cdd:cd14011   121 LQISEALSFLhNDVKLVHGNICPESVVINSNGEWKLAGFDFCISSEQATDQFPYFREYdpnlpplaqPNLNYLAPEYILS 200
                          90       100
                  ....*....|....*....|....*..
gi 226342982  878 SLYTTLSDVWSFGILLWEIFTLGGTPY 904
Cdd:cd14011   201 KTCDPASDMFSLGVLIYAIYNKGKPLF 227
STKc_CCRK cd07832
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the ...
805-903 3.87e-10

Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CCRK was previously called p42. It is a Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) which is essential for the activation of CDK2. It is indispensable for cell growth and has been implicated in the progression of glioblastoma multiforme. In the heart, a splice variant of CCRK with a different C-terminal half is expressed; this variant promotes cardiac cell growth and survival and is significantly down-regulated during the development of heart failure. The CCRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270826 [Multi-domain]  Cd Length: 287  Bit Score: 62.35  E-value: 3.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  805 GFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdIM---RDSNYISKGSTflplKW-MAPESIFNS-L 879
Cdd:cd07832   104 RYMRMLLKGVAYMHANRIMHRDLKPANLLISSTGVLKIADFGLAR-LFseeDPRLYSHQVAT----RWyRAPELLYGSrK 178
                          90       100
                  ....*....|....*....|....
gi 226342982  880 YTTLSDVWSFGILLWEIftLGGTP 903
Cdd:cd07832   179 YDEGVDLWAVGCIFAEL--LNGSP 200
STKc_PKC cd05570
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer ...
810-950 3.88e-10

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, classical PKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. Novel PKCs are calcium-independent, but require DAG and PS for activity, while atypical PKCs only require PS. PKCs phosphorylate and modify the activities of a wide variety of cellular proteins including receptors, enzymes, cytoskeletal proteins, transcription factors, and other kinases. They play a central role in signal transduction pathways that regulate cell migration and polarity, proliferation, differentiation, and apoptosis. Also included in this subfamily are the PKC-like proteins, called PKNs. The PKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270722 [Multi-domain]  Cd Length: 318  Bit Score: 62.62  E-value: 3.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNyisKGSTF--LPlKWMAPESIFNSLYTTLSDVW 887
Cdd:cd05570   105 ICLALQFLHERGIIYRDLKLDNVLLDAEGHIKIADFGMCKEGIWGGN---TTSTFcgTP-DYIAPEILREQDYGFSVDWW 180
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226342982  888 SFGILLWEiFTLGGTPY---PElpmnDQFYNAIKrGYRMAQPAHASDEIYEIMQkcweeKFETRPP 950
Cdd:cd05570   181 ALGVLLYE-MLAGQSPFegdDE----DELFEAIL-NDEVLYPRWLSREAVSILK-----GLLTKDP 235
STKc_EIF2AK2_PKR cd14047
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
808-897 4.12e-10

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Protein Kinase regulated by RNA; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKR (or EIF2AK2) contains an N-terminal double-stranded RNA (dsRNA) binding domain and a C-terminal catalytic kinase domain. It is activated by dsRNA, which is produced as a replication intermediate in virally infected cells. It plays a key role in mediating innate immune responses to viral infection. PKR is also directly activated by PACT (protein activator of PKR) and heparin, and is inhibited by viral proteins and RNAs. PKR also regulates transcription and signal transduction in diseased cells, playing roles in tumorigenesis and neurodegenerative diseases. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PKR subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270949 [Multi-domain]  Cd Length: 267  Bit Score: 61.74  E-value: 4.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLardIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVW 887
Cdd:cd14047   124 EQITKGVEYIHSKKLIHRDLKPSNIFLVDTGKVKIGDFGL---VTSLKNDGKRTKSKGTLSYMSPEQISSQDYGKEVDIY 200
                          90
                  ....*....|
gi 226342982  888 SFGILLWEIF 897
Cdd:cd14047   201 ALGLILFELL 210
STKc_Nek10 cd08528
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
820-899 4.72e-10

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. No function has yet been ascribed to Nek10. The gene encoding Nek10 is a putative causative gene for breast cancer; it is located within a breast cancer susceptibility loci on chromosome 3p24. Nek10 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270867 [Multi-domain]  Cd Length: 270  Bit Score: 61.75  E-value: 4.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  820 KNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISkgSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTL 899
Cdd:cd08528   133 KQIVHRDLKPNNIMLGEDDKVTITDFGLAKQKGPESSKMT--SVVGTILYSCPEIVQNEPYGEKADIWALGCILYQMCTL 210
STKc_PLK4 cd14186
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the ...
806-952 5.28e-10

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK4, also called SAK or STK18, is structurally different from other PLKs in that it contains only one polo box that can form two adjacent polo boxes and a functional PDB by homodimerization. It is required for late mitotic progression, cell survival, and embryonic development. It localizes to centrosomes and is required for centriole duplication and chromosomal stability. Overexpression of PLK4 may be associated with colon tumors. The PLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271088 [Multi-domain]  Cd Length: 256  Bit Score: 61.42  E-value: 5.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-MRDSNYISKGSTflPlKWMAPESIFNSLYTTLS 884
Cdd:cd14186   107 FMHQIVTGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLkMPHEKHFTMCGT--P-NYISPEIATRSAHGLES 183
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  885 DVWSFGILLWeIFTLGGTPYPELPMNDQFYNAIKRGYRMaqPAHASDEIYEIMQKCWEEKFETRPPFS 952
Cdd:cd14186   184 DVWSLGCMFY-TLLVGRPPFDTDTVKNTLNKVVLADYEM--PAFLSREAQDLIHQLLRKNPADRLSLS 248
STKc_PAK_II cd06648
Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze ...
809-919 6.12e-10

Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group II PAKs, also called non-conventional PAKs, include PAK4, PAK5, and PAK6. Group II PAKs contain PBD (p21-binding domain) and catalytic domains, but lack other motifs found in group I PAKs, such as an AID (autoinhibitory domain) and SH3 binding sites. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. While group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX, no such binding has been demonstrated for group II PAKs. Some known substrates of group II PAKs are also substrates of group I PAKs such as Raf, BAD, LIMK and GEFH1. Unique group II substrates include MARK/Par-1 and PDZ-RhoGEF. Group II PAKs play important roles in filopodia formation, neuron extension, cytoskeletal organization, and cell survival. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270815 [Multi-domain]  Cd Length: 261  Bit Score: 61.30  E-value: 6.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFG----LARDIMRDSNYIskGSTFlplkWMAPESIFNSLYTTLS 884
Cdd:cd06648   111 AVLKALSFLHSQGVIHRDIKSDSILLTSDGRVKLSDFGfcaqVSKEVPRRKSLV--GTPY----WMAPEVISRLPYGTEV 184
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 226342982  885 DVWSFGILLWEIFTlGGTPYpelpMNDQFYNAIKR 919
Cdd:cd06648   185 DIWSLGIMVIEMVD-GEPPY----FNEPPLQAMKR 214
PKc_Myt1 cd14050
Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze ...
813-953 6.16e-10

Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Myt1 is a cytoplasmic cell cycle checkpoint kinase that can keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of N-terminal thr (T14) and tyr (Y15) residues, leading to the delay of meiosis I entry. Meiotic progression is ensured by a two-step inhibition and downregulation of Myt1 by CDK1/XRINGO and p90Rsk during oocyte maturation. In addition, Myt1 targets cyclin B1/B2 and is essential for Golgi and ER assembly during telophase. In Drosophila, Myt1 may be a downstream target of Notch during eye development. The Myt1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270952 [Multi-domain]  Cd Length: 249  Bit Score: 61.17  E-value: 6.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  813 GMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMR-DSNYISKGSTflplKWMAPEsIFNSLYTTLSDVWSFGI 891
Cdd:cd14050   112 GLKHLHDHGLIHLDIKPANIFLSKDGVCKLGDFGLVVELDKeDIHDAQEGDP----RYMAPE-LLQGSFTKAADIFSLGI 186
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982  892 LLWEIFTlggtpYPELPMNDQFYNAIKRGYRMAQ-PAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14050   187 TILELAC-----NLELPSGGDGWHQLRQGYLPEEfTAGLSPELRSIIKLMMDPDPERRPTAED 244
PKc_MKK7 cd06618
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
807-906 6.95e-10

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK7 is a dual-specificity PK that phosphorylates and activates its downstream target, c-Jun N-terminal kinase (JNK), on specific threonine and tyrosine residues. Although MKK7 is capable of dual phosphorylation, it prefers to phosphorylate the threonine residue of JNK. Thus, optimal activation of JNK requires both MKK4 and MKK7. MKK7 is primarily activated by cytokines. MKK7 is essential for liver formation during embryogenesis. It plays roles in G2/M cell cycle arrest and cell growth. In addition, it is involved in the control of programmed cell death, which is crucial in oncogenesis, cancer chemoresistance, and antagonism to TNFalpha-induced killing, through its inhibition by Gadd45beta and the subsequent suppression of the JNK cascade. The MKK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270791 [Multi-domain]  Cd Length: 295  Bit Score: 61.62  E-value: 6.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  807 SYQVANGMDFLASK-NCVHRDLAARNVLICEGKLVKICDFGLArDIMRDSNYISKGSTFLPlkWMAPESI---FNSLYTT 882
Cdd:cd06618   120 TVSIVKALHYLKEKhGVIHRDVKPSNILLDESGNVKLCDFGIS-GRLVDSKAKTRSAGCAA--YMAPERIdppDNPKYDI 196
                          90       100
                  ....*....|....*....|....
gi 226342982  883 LSDVWSFGILLWEIFTlGGTPYPE 906
Cdd:cd06618   197 RADVWSLGISLVELAT-GQFPYRN 219
STKc_nPKC_delta cd05620
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze ...
806-904 7.41e-10

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. It slows down cell proliferation, inducing cell cycle arrest and enhancing cell differentiation. PKC-delta is also involved in the regulation of transcription as well as immune and inflammatory responses. It plays a central role in the genotoxic stress response that leads to DNA damaged-induced apoptosis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173710 [Multi-domain]  Cd Length: 316  Bit Score: 61.50  E-value: 7.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNyisKGSTFLPL-KWMAPESIFNSLYTTLS 884
Cdd:cd05620   101 YAAEIVCGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENVFGDN---RASTFCGTpDYIAPEILQGLKYTFSV 177
                          90       100
                  ....*....|....*....|
gi 226342982  885 DVWSFGILLWEIFtLGGTPY 904
Cdd:cd05620   178 DWWSFGVLLYEML-IGQSPF 196
STKc_BRSK1_2 cd14081
Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the ...
804-933 7.44e-10

Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BRSK1, also called SAD-B or SAD1 (Synapses of Amphids Defective homolog 1), and BRSK2, also called SAD-A, are highly expressed in mammalian forebrain. They play important roles in establishing neuronal polarity. BRSK1/2 double knock-out mice die soon after birth, showing thin cerebral cortices due to disordered subplate layers and neurons that lack distinct axons and dendrites. BRSK1 regulates presynaptic neurotransmitter release. Its activity fluctuates during cell cysle progression and it acts as a regulator of centrosome duplication. BRSK2 is also abundant in pancreatic islets, where it is involved in the regulation of glucose-stimulated insulin secretion. The BRSK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270983 [Multi-domain]  Cd Length: 255  Bit Score: 60.73  E-value: 7.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  804 VGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLAR----DIMRDSnyiSKGStflpLKWMAPESIFNSL 879
Cdd:cd14081   104 RKFFRQIISALDYCHSHSICHRDLKPENLLLDEKNNIKIADFGMASlqpeGSLLET---SCGS----PHYACPEVIKGEK 176
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  880 YTTL-SDVWSFGILLWEIFTlggtpyPELPMND----QFYNAIKRG-YRMaqPAHASDEI 933
Cdd:cd14081   177 YDGRkADIWSCGVILYALLV------GALPFDDdnlrQLLEKVKRGvFHI--PHFISPDA 228
STKc_PKA cd14209
Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze ...
809-938 8.00e-10

Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. The PKA subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271111 [Multi-domain]  Cd Length: 290  Bit Score: 61.27  E-value: 8.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrdsnyisKGSTF----LPlKWMAPESIFNSLYTTLS 884
Cdd:cd14209   109 QIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIKVTDFGFAKRV--------KGRTWtlcgTP-EYLAPEIILSKGYNKAV 179
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 226342982  885 DVWSFGILLWEiFTLGGTP-YPELPMndQFYNAIKRG-YRMaqPAHASDEIYEIMQ 938
Cdd:cd14209   180 DWWALGVLIYE-MAAGYPPfFADQPI--QIYEKIVSGkVRF--PSHFSSDLKDLLR 230
STKc_Mnk2 cd14173
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase ...
810-903 8.75e-10

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271075 [Multi-domain]  Cd Length: 288  Bit Score: 61.20  E-value: 8.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLiCEG----KLVKICDFGLARDIM--RDSNYISKGSTFLPL---KWMAPESI--FN- 877
Cdd:cd14173   109 IASALDFLHNKGIAHRDLKPENIL-CEHpnqvSPVKICDFDLGSGIKlnSDCSPISTPELLTPCgsaEYMAPEVVeaFNe 187
                          90       100
                  ....*....|....*....|....*...
gi 226342982  878 --SLYTTLSDVWSFGILLWeiFTLGGTP 903
Cdd:cd14173   188 eaSIYDKRCDLWSLGVILY--IMLSGYP 213
STKc_PAK2 cd06655
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the ...
813-948 9.00e-10

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK2 plays a role in pro-apoptotic signaling. It is cleaved and activated by caspases leading to morphological changes during apoptosis. PAK2 is also activated in response to a variety of stresses including DNA damage, hyperosmolarity, serum starvation, and contact inhibition, and may play a role in coordinating the stress response. PAK2 also contributes to cancer cell invasion through a mechanism distinct from that of PAK1. It belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132986 [Multi-domain]  Cd Length: 296  Bit Score: 61.28  E-value: 9.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  813 GMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyiSKGSTFLPLK-WMAPESIFNSLYTTLSDVWSFGI 891
Cdd:cd06655   127 ALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQ---SKRSTMVGTPyWMAPEVVTRKAYGPKVDIWSLGI 203
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  892 LLWEIFTlGGTPY-PELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETR 948
Cdd:cd06655   204 MAIEMVE-GEPPYlNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKR 260
STKc_PAK1 cd06654
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the ...
813-948 9.50e-10

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK1 is important in the regulation of many cellular processes including cytoskeletal dynamics, cell motility, growth, and proliferation. Although PAK1 has been regarded mainly as a cytosolic protein, recent reports indicate that PAK1 also exists in significant amounts in the nucleus, where it is involved in transcription modulation and in cell cycle regulatory events. PAK1 is also involved in transformation and tumorigenesis. Its overexpression, hyperactivation and increased nuclear accumulation is correlated to breast cancer invasiveness and progression. Nuclear accumulation is also linked to tamoxifen resistance in breast cancer cells. PAK1 belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270820 [Multi-domain]  Cd Length: 296  Bit Score: 61.28  E-value: 9.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  813 GMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyiSKGSTFLPLK-WMAPESIFNSLYTTLSDVWSFGI 891
Cdd:cd06654   128 ALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ---SKRSTMVGTPyWMAPEVVTRKAYGPKVDIWSLGI 204
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  892 LLWEIFTlGGTPY-PELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETR 948
Cdd:cd06654   205 MAIEMIE-GEPPYlNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKR 261
STKc_TAO2 cd06634
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze ...
798-949 1.06e-09

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human TAO2 is also known as prostate-derived Ste20-like kinase (PSK) and was identified in a screen for overexpressed RNAs in prostate cancer. TAO2 possesses mitogen-activated protein kinase (MAPK) kinase kinase activity and activates both p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating their respective MAP/ERK kinases, MEK3/MEK6 and MKK4/MKK7. It contains a long C-terminal extension with autoinhibitory segments, and is activated by the release of this inhibition and the phosphorylation of its activation loop serine. TAO2 functions as a regulator of actin cytoskeletal and microtubule organization. In addition, it regulates the transforming growth factor-activated kinase 1 (TAK1), which is a MAPKKK that plays an essential role in the signaling pathways of tumor necrosis factor, interleukin 1, and Toll-like receptor. The TAO2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270804 [Multi-domain]  Cd Length: 308  Bit Score: 61.19  E-value: 1.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  798 LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLArDIMRDSNYISkGSTFlplkWMAPESIF- 876
Cdd:cd06634   112 LQEVEIAAITHGALQGLAYLHSHNMIHRDVKAGNILLTEPGLVKLGDFGSA-SIMAPANSFV-GTPY----WMAPEVILa 185
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226342982  877 --NSLYTTLSDVWSFGILLWEiftLGGTPYPELPMN--DQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd06634   186 mdEGQYDGKVDVWSLGITCIE---LAERKPPLFNMNamSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRP 259
STKc_WNK cd13983
Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze ...
809-950 1.11e-09

Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNKs comprise a subfamily of STKs with an unusual placement of a catalytic lysine relative to all other protein kinases. They are critical in regulating ion balance and are thus, important components in the control of blood pressure. They are also involved in cell signaling, survival, proliferation, and organ development. WNKs are activated by hyperosmotic or low-chloride hypotonic stress and they function upstream of SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. There are four vertebrate WNKs which show varying expression patterns. WNK1 and WNK2 are widely expressed while WNK3 and WNK4 show a more restricted expression pattern. Because mutations in human WNK1 and WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension (due to increased sodium reabsorption) and hyperkalemia (due to impaired renal potassium secretion), there are more studies conducted on these two proteins, compared to WNK2 and WNK3. The WNK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270885 [Multi-domain]  Cd Length: 258  Bit Score: 60.32  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKN--CVHRDLAARNVLI--CEGKlVKICDFGLARdIMRDSNYISKGSTflpLKWMAPEsIFNSLYTTLS 884
Cdd:cd13983   110 QILEGLNYLHTRDppIIHRDLKCDNIFIngNTGE-VKIGDLGLAT-LLRQSFAKSVIGT---PEFMAPE-MYEEHYDEKV 183
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  885 DVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRmaqPAH----ASDEIYEIMQKCWEEKfETRPP 950
Cdd:cd13983   184 DIYAFGMCLLEMAT-GEYPYSECTNAAQIYKKVTSGIK---PESlskvKDPELKDFIEKCLKPP-DERPS 248
STKc_CDK10 cd07845
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs ...
789-898 1.19e-09

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK10, also called PISSLRE, is essential for cell growth and proliferation, and acts through the G2/M phase of the cell cycle. CDK10 has also been identified as an important factor in endocrine therapy resistance in breast cancer. CDK10 silencing increases the transcription of c-RAF and the activation of the p42/p44 MAPK pathway, which leads to antiestrogen resistance. Patients who express low levels of CDK10 relapse early on tamoxifen. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK10 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173742 [Multi-domain]  Cd Length: 309  Bit Score: 60.84  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  789 ATLINDSPV-LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdiMRDSNYISKGSTFLPL 867
Cdd:cd07845    95 ASLLDNMPTpFSESQVKCLMLQLLRGLQYLHENFIIHRDLKVSNLLLTDKGCLKIADFGLAR--TYGLPAKPMTPKVVTL 172
                          90       100       110
                  ....*....|....*....|....*....|..
gi 226342982  868 KWMAPESIFNSL-YTTLSDVWSFGILLWEIFT 898
Cdd:cd07845   173 WYRAPELLLGCTtYTTAIDMWAVGCILAELLA 204
STKc_MEKK1 cd06630
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
789-950 1.20e-09

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK1 is a MAPK kinase kinase (MAPKKK or MKKK) that phosphorylates and activates activates the ERK1/2 and c-Jun N-terminal kinase (JNK) pathways by activating their respective MAPKKs, MEK1/2 and MKK4/MKK7, respectively. MEKK1 is important in regulating cell survival and apoptosis. MEKK1 also plays a role in cell migration, tissue maintenance and homeostasis, and wound healing. The MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270800 [Multi-domain]  Cd Length: 268  Bit Score: 60.52  E-value: 1.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  789 ATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLI-CEGKLVKICDFG----LARDIMRDSNYisKGST 863
Cdd:cd06630    91 ASLLSKYGAFSENVIINYTLQILRGLAYLHDNQIIHRDLKGANLLVdSTGQRLRIADFGaaarLASKGTGAGEF--QGQL 168
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  864 FLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPelpmNDQFYNAIKRGYRMAQ-------PAHASDEIYEI 936
Cdd:cd06630   169 LGTIAFMAPEVLRGEQYGRSCDVWSVGCVIIEMAT-AKPPWN----AEKISNHLALIFKIASattpppiPEHLSPGLRDV 243
                         170
                  ....*....|....
gi 226342982  937 MQKCWEEKFETRPP 950
Cdd:cd06630   244 TLRCLELQPEDRPP 257
PTZ00267 PTZ00267
NIMA-related protein kinase; Provisional
808-1009 1.54e-09

NIMA-related protein kinase; Provisional


Pssm-ID: 140293 [Multi-domain]  Cd Length: 478  Bit Score: 61.57  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDiMRDSNYISKGSTFLPLK-WMAPESIFNSLYTTLSDV 886
Cdd:PTZ00267  176 YQIVLALDEVHSRKMMHRDLKSANIFLMPTGIIKLGDFGFSKQ-YSDSVSLDVASSFCGTPyYLAPELWERKRYSKKADM 254
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  887 WSFGILLWEIFTLgGTPYpELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLERLLGEGY 966
Cdd:PTZ00267  255 WSLGVILYELLTL-HRPF-KGPSQREIMQQVLYGKYDPFPCPVSSGMKALLDPLLSKNPALRPTTQQLLHTEFLKYVANL 332
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 226342982  967 KKKYQQVDEEFLRSDHPAILR----SQARFPGIHSLRSPLDTSSVLY 1009
Cdd:PTZ00267  333 FQDIVRHSETISPHDREEILRqlqeSGERAPPPSSIRYGVVTSDVTH 379
STKc_ULK2 cd14201
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the ...
806-904 1.60e-09

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK2 is ubiquitously expressed and is essential in autophagy induction. It displays partially redundant functions with ULK1 and is able to compensate for the loss of ULK1 in non-selective autophagy. It also displays neuron-specific functions and is important in axon development. The ULK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271103 [Multi-domain]  Cd Length: 271  Bit Score: 60.02  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLIC---------EGKLVKICDFGLARDImrDSNYISKGSTFLPLkWMAPESIF 876
Cdd:cd14201   110 FLQQIAAAMRILHSKGIIHRDLKPQNILLSyasrkkssvSGIRIKIADFGFARYL--QSNMMAATLCGSPM-YMAPEVIM 186
                          90       100
                  ....*....|....*....|....*...
gi 226342982  877 NSLYTTLSDVWSFGILLWEIFtLGGTPY 904
Cdd:cd14201   187 SQHYDAKADLWSIGTVIYQCL-VGKPPF 213
STKc_p38alpha cd07877
Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase ...
808-913 1.72e-09

Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38alpha/MAPK14 is expressed in most tissues and is the major isoform involved in the immune and inflammatory response. It is the central p38 MAPK involved in myogenesis. It plays a role in regulating cell cycle check-point transition and promoting cell differentiation. p38alpha also regulates cell proliferation and death through crosstalk with the JNK pathway. Its substrates include MAPK activated protein kinase 2 (MK2), MK5, and the transcription factors ATF2 and Mitf. p38 kinases MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143382 [Multi-domain]  Cd Length: 345  Bit Score: 60.82  E-value: 1.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyiskgSTFLPLKWM-APESIFNSL-YTTLSD 885
Cdd:cd07877   127 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM------TGYVATRWYrAPEIMLNWMhYNQTVD 200
                          90       100
                  ....*....|....*....|....*...
gi 226342982  886 VWSFGILLWEIFTlGGTPYPELPMNDQF 913
Cdd:cd07877   201 IWSVGCIMAELLT-GRTLFPGTDHIDQL 227
PKc_DYRK cd14210
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
605-903 1.99e-09

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase; Protein Kinases (PKs), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK) subfamily, catalytic (c) domain. Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. The DYRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein S/T PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. Vertebrates contain multiple DYRKs (DYRK1-4) and mammals contain two types of DYRK1 proteins, DYRK1A and DYRK1B. DYRK1A is involved in neuronal differentiation and is implicated in the pathogenesis of DS (Down syndrome). DYRK1B plays a critical role in muscle differentiation by regulating transcription, cell motility, survival, and cell cycle progression. It is overexpressed in many solid tumors where it acts as a tumor survival factor. DYRK2 promotes apoptosis in response to DNA damage by phosphorylating the tumor suppressor p53, while DYRK3 promotes cell survival by phosphorylating SIRT1 and promoting p53 deacetylation. DYRK4 is a testis-specific kinase that may function during spermiogenesis.


Pssm-ID: 271112 [Multi-domain]  Cd Length: 311  Bit Score: 60.25  E-value: 1.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  605 TLGSGAFGQVVEATAHgLSHSQatmkVAVKMLKSTARSSeKQALMsELKIMSHL---GPHL--NVVNLLGACTKGGPIYI 679
Cdd:cd14210    20 VLGKGSFGQVVKCLDH-KTGQL----VAIKIIRNKKRFH-QQALV-EVKILKHLndnDPDDkhNIVRYKDSFIFRGHLCI 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  680 ITEycrygdlvdYLHRNKHTFLQrhSNKHcppsaelysnalpVGFSLPShlnltgesdggymdmskdesidyvpmldmkg 759
Cdd:cd14210    93 VFE---------LLSINLYELLK--SNNF-------------QGLSLSL------------------------------- 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  760 dIKYadiespsymapydnyvpsapertyratlindspvlsytdlvgFSYQVANGMDFLASKNCVHRDLAARNVLIC-EGK 838
Cdd:cd14210   118 -IRK------------------------------------------FAKQILQALQFLHKLNIIHCDLKPENILLKqPSK 154
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  839 L-VKICDFGlardimrdS---------NYISkgSTFlplkWMAPESIFNSLYTTLSDVWSFGILLWEIFTlgGTP 903
Cdd:cd14210   155 SsIKVIDFG--------SscfegekvyTYIQ--SRF----YRAPEVILGLPYDTAIDMWSLGCILAELYT--GYP 213
PKc_MKK3_6 cd06617
Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase ...
810-953 2.08e-09

Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK3 and MKK6 are dual-specificity PKs that phosphorylate and activate their downstream target, p38 MAPK, on specific threonine and tyrosine residues. MKK3/6 play roles in the regulation of cell cycle progression, cytokine- and stress-induced apoptosis, oncogenic transformation, and adult tissue regeneration. In addition, MKK6 plays a critical role in osteoclast survival in inflammatory disease while MKK3 is associated with tumor invasion, progression, and poor patient survival in glioma. The MKK3/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173729 [Multi-domain]  Cd Length: 283  Bit Score: 59.75  E-value: 2.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASK-NCVHRDLAARNVLICEGKLVKICDFGLARDIMrdsNYISKGSTFLPLKWMAPESIFNSL----YTTLS 884
Cdd:cd06617   112 IVKALEYLHSKlSVIHRDVKPSNVLINRNGQVKLCDFGISGYLV---DSVAKTIDAGCKPYMAPERINPELnqkgYDVKS 188
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  885 DVWSFGILLWEIFTLG------GTPY-----------PELPMnDQFynaikrgyrmaqpahaSDEIYEIMQKCWEEKFET 947
Cdd:cd06617   189 DVWSLGITMIELATGRfpydswKTPFqqlkqvveepsPQLPA-EKF----------------SPEFQDFVNKCLKKNYKE 251

                  ....*.
gi 226342982  948 RPPFSQ 953
Cdd:cd06617   252 RPNYPE 257
STKc_Nek11 cd08222
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
809-899 2.19e-09

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek11 is involved, through direct phosphorylation, in regulating the degradation of Cdc25A (Cell Division Cycle 25 homolog A), which plays a role in cell cycle progression and in activating cyclin dependent kinases. Nek11 is activated by CHK1 (CHeckpoint Kinase 1) and may be involved in the G2/M checkpoint. Nek11 may also play a role in the S-phase checkpoint as well as in DNA replication and genotoxic stress responses. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270861 [Multi-domain]  Cd Length: 260  Bit Score: 59.36  E-value: 2.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGkLVKICDFGLARDIMRDSNYiskGSTF--LPLkWMAPESIFNSLYTTLSDV 886
Cdd:cd08222   114 QLLLAVQYMHERRILHRDLKAKNIFLKNN-VIKVGDFGISRILMGTSDL---ATTFtgTPY-YMSPEVLKHEGYNSKSDI 188
                          90
                  ....*....|...
gi 226342982  887 WSFGILLWEIFTL 899
Cdd:cd08222   189 WSLGCILYEMCCL 201
STKc_Chk2 cd14084
Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze ...
806-927 2.21e-09

Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Checkpoint Kinase 2 (Chk2) plays an important role in cellular responses to DNA double-strand breaks and related lesions. It is phosphorylated and activated by ATM kinase, resulting in its dissociation from sites of damage to phosphorylate downstream targets such as BRCA1, p53, cell cycle transcription factor E2F1, the promyelocytic leukemia protein (PML) involved in apoptosis, and CDC25 phosphatases, among others. Mutations in Chk2 is linked to a variety of cancers including familial breast cancer, myelodysplastic syndromes, prostate cancer, lung cancer, and osteosarcomas. Chk2 contains an N-terminal SQ/TQ cluster domain (SCD), a central forkhead-associated (FHA) domain, and a C-terminal catalytic kinase domain. The Chk2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270986 [Multi-domain]  Cd Length: 275  Bit Score: 59.71  E-value: 2.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLiCEGK----LVKICDFGLARDIMRDSNYISKGSTflPLkWMAPEsIFNSL-- 879
Cdd:cd14084   116 YFYQMLLAVKYLHSNGIIHRDLKPENVL-LSSQeeecLIKITDFGLSKILGETSLMKTLCGT--PT-YLAPE-VLRSFgt 190
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 226342982  880 --YTTLSDVWSFGILLWeiFTLGGTP-----YPELPMNDQfynaIKRG-YRMAQPA 927
Cdd:cd14084   191 egYTRAVDCWSLGVILF--ICLSGYPpfseeYTQMSLKEQ----ILSGkYTFIPKA 240
STKc_FA2-like cd08529
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar ...
806-949 2.33e-09

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii FA2 was discovered in a genetic screen for deflagellation-defective mutants. It is essential for basal-body/centriole-associated microtubule severing, and plays a role in cell cycle progression. No cellular function has yet been ascribed to CNK4. The Chlamydomonas reinhardtii FA2-like subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily contains FA2 and CNK4. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270868 [Multi-domain]  Cd Length: 256  Bit Score: 59.35  E-value: 2.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISK--GSTFlplkWMAPESIFNSLYTTL 883
Cdd:cd08529   106 FFIQTLLGLSHLHSKKILHRDIKSMNIFLDKGDNVKIGDLGVAKILSDTTNFAQTivGTPY----YLSPELCEDKPYNEK 181
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  884 SDVWSFGILLWEIFTLggtpypELPMNDQFYNA----IKRGYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd08529   182 SDVWALGCVLYELCTG------KHPFEAQNQGAlilkIVRGKYPPISASYSQDLSQLIDSCLTKDYRQRP 245
STKc_RSK_N cd05582
N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; ...
809-904 2.52e-09

N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), p90-RSKs, or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270734 [Multi-domain]  Cd Length: 317  Bit Score: 60.11  E-value: 2.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNyisKGSTFL-PLKWMAPESIFNSLYTTLSDVW 887
Cdd:cd05582   105 ELALALDHLHSLGIIYRDLKPENILLDEDGHIKLTDFGLSKESIDHEK---KAYSFCgTVEYMAPEVVNRRGHTQSADWW 181
                          90
                  ....*....|....*..
gi 226342982  888 SFGILLWEIFTlGGTPY 904
Cdd:cd05582   182 SFGVLMFEMLT-GSLPF 197
STKc_Pho85 cd07836
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; ...
806-912 2.56e-09

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Pho85 is a multifunctional CDK in yeast. It is regulated by 10 different cyclins (Pcls) and plays a role in G1 progression, cell polarity, phosphate and glycogen metabolism, gene expression, and in signaling changes in the environment. It is not essential for yeast viability and is the functional homolog of mammalian CDK5, which plays a role in central nervous system development. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The Pho85 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143341 [Multi-domain]  Cd Length: 284  Bit Score: 59.80  E-value: 2.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISkgSTFLPLKWMAPESIFNS-LYTTLS 884
Cdd:cd07836   105 FTYQLLKGIAFCHENRVLHRDLKPQNLLINKRGELKLADFGLARAFGIPVNTFS--NEVVTLWYRAPDVLLGSrTYSTSI 182
                          90       100
                  ....*....|....*....|....*....
gi 226342982  885 DVWSFGILLWEIFTlgGTP-YPELPMNDQ 912
Cdd:cd07836   183 DIWSVGCIMAEMIT--GRPlFPGTNNEDQ 209
PTK_Tyk2_rpt1 cd05076
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; Tyk2 is ...
809-951 2.60e-09

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; Tyk2 is widely expressed in many tissues. It is involved in signaling via the cytokine receptors IFN-alphabeta, IL-6, IL-10, IL-12, IL-13, and IL-23. It mediates cell surface urokinase receptor (uPAR) signaling and plays a role in modulating vascular smooth muscle cell (VSMC) functional behavior in response to injury. Tyk2 is also important in dendritic cell function and T helper (Th)1 cell differentiation. A homozygous mutation of Tyk2 was found in a patient with hyper-IgE syndrome (HIES), a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and elevated serum IgE. This suggests that Tyk2 may play important roles in multiple cytokine signaling involved in innate and adaptive immunity. Tyk2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. It modulates the kinase activity of the C-terminal catalytic domain. The Tyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270661 [Multi-domain]  Cd Length: 273  Bit Score: 59.54  E-value: 2.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKL-------VKICDFGLARDIMRDSNYISKgstflpLKWMAPESIFN-SLY 880
Cdd:cd05076   124 QLASALSYLENKNLVHGNVCAKNILLARLGLeegtspfIKLSDPGVGLGVLSREERVER------IPWIAPECVPGgNSL 197
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982  881 TTLSDVWSFGILLWEIFTLGGTPYPE--LPMNDQFYnaiKRGYRMAQPahASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05076   198 STAADKWGFGATLLEICFNGEAPLQSrtPSEKERFY---QRQHRLPEP--SCPELATLISQCLTYEPTQRPSF 265
STKc_MAP4K4_6_N cd06636
N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase ...
809-953 2.66e-09

N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K4 is also called Nck Interacting kinase (NIK). It facilitates the activation of the MAPKs, extracellular signal-regulated kinase (ERK) 1, ERK2, and c-Jun N-terminal kinase (JNK), by phosphorylating and activating MEKK1. MAP4K4 plays a role in tumor necrosis factor (TNF) alpha-induced insulin resistance. MAP4K4 silencing in skeletal muscle cells from type II diabetic patients restores insulin-mediated glucose uptake. MAP4K4, through JNK, also plays a broad role in cell motility, which impacts inflammation, homeostasis, as well as the invasion and spread of cancer. MAP4K4 is found to be highly expressed in most tumor cell lines relative to normal tissue. MAP4K6 (also called MINK for Misshapen/NIKs-related kinase) is activated after Ras induction and mediates activation of p38 MAPK. MAP4K6 plays a role in cell cycle arrest, cytoskeleton organization, cell adhesion, and cell motility. The MAP4K4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270806 [Multi-domain]  Cd Length: 282  Bit Score: 59.64  E-value: 2.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDsnyISKGSTFLPLK-WMAPESIF-----NSLYTT 882
Cdd:cd06636   129 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT---VGRRNTFIGTPyWMAPEVIAcdenpDATYDY 205
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  883 LSDVWSFGILLWEIfTLGGTPYPEL-PMNDQFYNAIKRGYRMaQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd06636   206 RSDIWSLGITAIEM-AEGAPPLCDMhPMRALFLIPRNPPPKL-KSKKWSKKFIDFIEGCLVKNYLSRPSTEQ 275
PKc_MKK4 cd06616
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
807-906 2.91e-09

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK4 is a dual-specificity PK that phosphorylates and activates the downstream targets, c-Jun N-terminal kinase (JNK) and p38 MAPK, on specific threonine and tyrosine residues. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. Their activation is associated with the induction of cell death. Mice deficient in MKK4 die during embryogenesis and display anemia, severe liver hemorrhage, and abnormal hepatogenesis. MKK4 may also play roles in the immune system and in cardiac hypertrophy. It plays a major role in cancer as a tumor and metastasis suppressor. Under certain conditions, MKK4 is pro-oncogenic. The MKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270790 [Multi-domain]  Cd Length: 291  Bit Score: 59.69  E-value: 2.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  807 SYQVANGMDFLASK-NCVHRDLAARNVLICEGKLVKICDFGLARDIMrDSNYISKGSTFLPlkWMAPESIFNSL----YT 881
Cdd:cd06616   115 AVATVKALNYLKEElKIIHRDVKPSNILLDRNGNIKLCDFGISGQLV-DSIAKTRDAGCRP--YMAPERIDPSAsrdgYD 191
                          90       100
                  ....*....|....*....|....*
gi 226342982  882 TLSDVWSFGILLWEIFTlGGTPYPE 906
Cdd:cd06616   192 VRSDVWSLGITLYEVAT-GKFPYPK 215
PTZ00036 PTZ00036
glycogen synthase kinase; Provisional
806-905 3.10e-09

glycogen synthase kinase; Provisional


Pssm-ID: 173333 [Multi-domain]  Cd Length: 440  Bit Score: 60.43  E-value: 3.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLI-CEGKLVKICDFGLARDIM---RDSNYISkgSTFlplkWMAPESIFNSL-Y 880
Cdd:PTZ00036  175 YSYQLCRALAYIHSKFICHRDLKPQNLLIdPNTHTLKLCDFGSAKNLLagqRSVSYIC--SRF----YRAPELMLGATnY 248
                          90       100
                  ....*....|....*....|....*
gi 226342982  881 TTLSDVWSFGILLWEIFtLGgtpYP 905
Cdd:PTZ00036  249 TTHIDLWSLGCIIAEMI-LG---YP 269
STKc_Nek9 cd08221
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
802-949 3.32e-09

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek9, also called Nercc1, is primarily a cytoplasmic protein but can also localize in the nucleus. It is involved in modulating chromosome alignment and splitting during mitosis. It interacts with the gamma-tubulin ring complex and the Ran GTPase, and is implicated in microtubule organization. Nek9 associates with FACT (FAcilitates Chromatin Transcription) and modulates interphase progression. It also interacts with Nek6, and Nek7, during mitosis, resulting in their activation. Nek9 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270860 [Multi-domain]  Cd Length: 256  Bit Score: 58.98  E-value: 3.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  802 DLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrDSNYISKGSTFLPLKWMAPESIFNSLYT 881
Cdd:cd08221   102 VVLWYLYQIVSAVSHIHKAGILHRDIKTLNIFLTKADLVKLGDFGISKVL--DSESSMAESIVGTPYYMSPELVQGVKYN 179
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  882 TLSDVWSFGILLWEIFTLGGTPYPELPMNdqFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd08221   180 FKSDIWAVGCVLYELLTLKRTFDATNPLR--LAVKIVQGEYEDIDEQYSEEIIQLVHDCLHQDPEDRP 245
PTK_Jak1_rpt1 cd05077
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1; Jak1 is widely ...
809-951 3.36e-09

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1; Jak1 is widely expressed in many tissues. Many cytokines are dependent on Jak1 for signaling, including those that use the shared receptor subunits, common gamma chain (IL-2, IL-4, IL-7, IL-9, IL-15, IL-21) and gp130 (IL-6, IL-11, oncostatin M, G-CSF, and IFNs, among others). The many varied interactions of Jak1 and its ubiquitous expression suggest many biological roles. Jak1 is important in neurological development, as well as in lymphoid development and function. It also plays a role in the pathophysiology of cardiac hypertrophy and heart failure. A mutation in the ATP-binding site of Jak1 was identified in a human uterine leiomyosarcoma cell line, resulting in defective cytokine induction and antigen presentation, thus allowing the tumor to evade the immune system. Jak1 is a cytoplasmic (or nonreceptor) PTK containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. It modulates the kinase activity of the C-terminal catalytic domain. The Jak1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270662 [Multi-domain]  Cd Length: 266  Bit Score: 59.18  E-value: 3.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICE-------GKLVKICDFGLARDIMRDSNYISKgstflpLKWMAPESIFNSLYT 881
Cdd:cd05077   117 QLASALSYLEDKDLVHGNVCTKNILLARegidgecGPFIKLSDPGIPITVLSRQECVER------IPWIAPECVEDSKNL 190
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982  882 TLS-DVWSFGILLWEIFTLGGTPYPE--LPMNDQFYNAikrGYRMAQPahASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd05077   191 SIAaDKWSFGTTLWEICYNGEIPLKDktLAEKERFYEG---QCMLVTP--SCKELADLMTHCMNYDPNQRPFF 258
STKc_CDKL5 cd07848
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs ...
806-918 3.77e-09

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mutations in the gene encoding CDKL5, previously called STK9, are associated with early onset epilepsy and severe mental retardation [X-linked infantile spasm syndrome (ISSX) or West syndrome]. In addition, CDKL5 mutations also sometimes cause a phenotype similar to Rett syndrome (RTT), a progressive neurodevelopmental disorder. These pathogenic mutations are located in the N-terminal portion of the protein within the kinase domain. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270838 [Multi-domain]  Cd Length: 287  Bit Score: 59.24  E-value: 3.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMR--DSNYiskgSTFLPLKWM-APESIFNSLYTT 882
Cdd:cd07848   105 YIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEgsNANY----TEYVATRWYrSPELLLGAPYGK 180
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 226342982  883 LSDVWSFGILLWEIfTLGGTPYPELPMNDQFYNAIK 918
Cdd:cd07848   181 AVDMWSVGCILGEL-SDGQPLFPGESEIDQLFTIQK 215
STKc_PKN cd05589
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer ...
813-905 3.95e-09

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKN has a C-terminal catalytic domain that is highly homologous to PKCs. Its unique N-terminal regulatory region contains antiparallel coiled-coil (ACC) domains. In mammals, there are three PKN isoforms from different genes (designated PKN-alpha, beta, and gamma), which show different enzymatic properties, tissue distribution, and varied functions. PKN can be activated by the small GTPase Rho, and by fatty acids such as arachidonic and linoleic acids. It is involved in many biological processes including cytokeletal regulation, cell adhesion, vesicle transport, glucose transport, regulation of meiotic maturation and embryonic cell cycles, signaling to the nucleus, and tumorigenesis. The PKN subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270741 [Multi-domain]  Cd Length: 326  Bit Score: 59.62  E-value: 3.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  813 GMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMrdsNYISKGSTF--LPlKWMAPESIFNSLYTTLSDVWSFG 890
Cdd:cd05589   113 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGM---GFGDRTSTFcgTP-EFLAPEVLTDTSYTRAVDWWGLG 188
                          90
                  ....*....|....*
gi 226342982  891 ILLWEIFtLGGTPYP 905
Cdd:cd05589   189 VLIYEML-VGESPFP 202
STKc_Titin cd14104
Catalytic domain of the Giant Serine/Threonine Kinase Titin; STKs catalyze the transfer of the ...
792-902 3.97e-09

Catalytic domain of the Giant Serine/Threonine Kinase Titin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Titin, also called connectin, is a muscle-specific elastic protein and is the largest known protein to date. It contains multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains, and a single kinase domain near the C-terminus. It spans half of the sarcomere, the repeating contractile unit of striated muscle, and performs mechanical and catalytic functions. Titin contributes to the passive force generated when muscle is stretched during relaxation. Its kinase domain phosphorylates and regulates the muscle protein telethonin, which is required for sarcomere formation in differentiating myocytes. In addition, titin binds many sarcomere proteins and acts as a molecular scaffold for filament formation during myofibrillogenesis. The Titin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271006 [Multi-domain]  Cd Length: 277  Bit Score: 59.10  E-value: 3.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  792 INDSPV-LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLIC--EGKLVKICDFGLARDIMRDSNYiskGSTFLPLK 868
Cdd:cd14104    87 ITTARFeLNEREIVSYVRQVCEALEFLHSKNIGHFDIRPENIIYCtrRGSYIKIIEFGQSRQLKPGDKF---RLQYTSAE 163
                          90       100       110
                  ....*....|....*....|....*....|....
gi 226342982  869 WMAPESIFNSLYTTLSDVWSFGILLWEIftLGGT 902
Cdd:cd14104   164 FYAPEVHQHESVSTATDMWSLGCLVYVL--LSGI 195
STKc_IKK_alpha cd14039
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
792-895 4.40e-09

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKalpha is involved in the non-canonical or alternative pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The non-canonical pathway functions in cells lacking NEMO (NF-kB Essential MOdulator) and IKKbeta. It is induced by a subset of TNFR family members including CD40, RANK, and B cell-activating factor receptor. IKKalpha processes the Inhibitor of NF-kB (IkB)-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus. This pathway is dependent on NIK (NF-kB Inducing Kinase) which phosphorylates and activates IKKalpha. The IKKalpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270941 [Multi-domain]  Cd Length: 289  Bit Score: 59.16  E-value: 4.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  792 INDSPVLSYTDLVGfsyqvaNGMDFLASKNCVHRDLAARNVLI--CEGKLV-KICDFGLARDIMRDSNYISKGSTflpLK 868
Cdd:cd14039    96 LKESQVLSLLSDIG------SGIQYLHENKIIHRDLKPENIVLqeINGKIVhKIIDLGYAKDLDQGSLCTSFVGT---LQ 166
                          90       100
                  ....*....|....*....|....*..
gi 226342982  869 WMAPESIFNSLYTTLSDVWSFGILLWE 895
Cdd:cd14039   167 YLAPELFENKSYTVTVDYWSFGTMVFE 193
STKc_Nek5 cd08225
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
797-899 4.49e-09

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The specific function of Nek5 is unknown. Nek5 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173765 [Multi-domain]  Cd Length: 257  Bit Score: 58.43  E-value: 4.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  797 VLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICE-GKLVKICDFGLARdIMRDSNYISKGSTFLPLkWMAPESI 875
Cdd:cd08225    97 LFSEDQILSWFVQISLGLKHIHDRKILHRDIKSQNIFLSKnGMVAKLGDFGIAR-QLNDSMELAYTCVGTPY-YLSPEIC 174
                          90       100
                  ....*....|....*....|....
gi 226342982  876 FNSLYTTLSDVWSFGILLWEIFTL 899
Cdd:cd08225   175 QNRPYNNKTDIWSLGCVLYELCTL 198
STKc_TAO3 cd06633
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze ...
798-945 4.71e-09

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO3 is also known as JIK (c-Jun N-terminal kinase inhibitory kinase) or KFC (kinase from chicken). It specifically activates JNK, presumably by phosphorylating and activating MKK4/MKK7. In Saccharomyces cerevisiae, TAO3 is a component of the RAM (regulation of Ace2p activity and cellular morphogenesis) signaling pathway. TAO3 is upregulated in retinal ganglion cells after axotomy, and may play a role in apoptosis. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270803 [Multi-domain]  Cd Length: 313  Bit Score: 59.28  E-value: 4.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  798 LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYIskGSTFlplkWMAPESIF- 876
Cdd:cd06633   118 LQEVEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASPANSFV--GTPY----WMAPEVILa 191
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226342982  877 --NSLYTTLSDVWSFGILLWEiftLGGTPYPELPMndqfyNAIKRGYRMAQ---PAHASDEiyeimqkcWEEKF 945
Cdd:cd06633   192 mdEGQYDGKVDIWSLGITCIE---LAERKPPLFNM-----NAMSALYHIAQndsPTLQSNE--------WTDSF 249
STKc_Aurora-A cd14116
Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer ...
809-951 4.80e-09

Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2, which also localizes the kinase to spindle microtubules. Aurora-A is overexpressed in many cancer types such as prostate, ovarian, breast, bladder, gastric, and pancreatic. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271018 [Multi-domain]  Cd Length: 258  Bit Score: 58.43  E-value: 4.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLArdIMRDSnyiSKGSTFL-PLKWMAPESIFNSLYTTLSDVW 887
Cdd:cd14116   113 ELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS--VHAPS---SRRTTLCgTLDYLPPEMIEGRMHDEKVDLW 187
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226342982  888 SFGILLWEiFTLGGTPYpELPMNDQFYNAIKRgYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd14116   188 SLGVLCYE-FLVGKPPF-EANTYQETYKRISR-VEFTFPDFVTEGARDLISRLLKHNPSQRPML 248
STKc_Mnk cd14090
Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase ...
810-904 4.85e-09

Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase signal-integrating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270992 [Multi-domain]  Cd Length: 289  Bit Score: 58.97  E-value: 4.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLiCE--GKL--VKICDFGLARDImRDSNYISKGSTFLPL-------KWMAPESI--F 876
Cdd:cd14090   109 IASALDFLHDKGIAHRDLKPENIL-CEsmDKVspVKICDFDLGSGI-KLSSTSMTPVTTPELltpvgsaEYMAPEVVdaF 186
                          90       100       110
                  ....*....|....*....|....*....|.
gi 226342982  877 ---NSLYTTLSDVWSFGILLWeIFTLGGTPY 904
Cdd:cd14090   187 vgeALSYDKRCDLWSLGVILY-IMLCGYPPF 216
STKc_MAST_like cd05579
Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs ...
806-911 4.94e-09

Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAST kinases, MAST-like (MASTL) kinases (also called greatwall kinase or Gwl), and fungal kinases with similarity to Saccharomyces cerevisiae Rim15 and Schizosaccharomyces pombe cek1. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. MASTL kinases carry only a catalytic domain which contains a long insert relative to other kinases. The fungal kinases in this subfamily harbor other domains in addition to a central catalytic domain, which like in MASTL, also contains an insert relative to MAST kinases. Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MASTL/Gwl is involved in the regulation of mitotic entry, mRNA stabilization, and DNA checkpoint recovery. The fungal proteins Rim15 and cek1 are involved in the regulation of meiosis and mitosis, respectively. The MAST-like kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270731 [Multi-domain]  Cd Length: 272  Bit Score: 58.77  E-value: 4.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLAR-DIMRDSNYISKGSTFLPLK------------WMAP 872
Cdd:cd05579    98 YIAEIVLALEYLHSHGIIHRDLKPDNILIDANGHLKLTDFGLSKvGLVRRQIKLSIQKKSNGAPekedrrivgtpdYLAP 177
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 226342982  873 ESIFNSLYTTLSDVWSFGILLWEIFTlgGTPypelPMND 911
Cdd:cd05579   178 EILLGQGHGKTVDWWSLGVILYEFLV--GIP----PFHA 210
STKc_p38 cd07851
Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs ...
808-912 5.29e-09

Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They function in the regulation of the cell cycle, cell development, cell differentiation, senescence, tumorigenesis, apoptosis, pain development and pain progression, and immune responses. p38 kinases are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. p38 substrates include other protein kinases and factors that regulate transcription, nuclear export, mRNA stability and translation. p38 kinases are drug targets for the inflammatory diseases psoriasis, rheumatoid arthritis, and chronic pulmonary disease. Vertebrates contain four isoforms of p38, named alpha, beta, gamma, and delta, which show varying substrate specificity and expression patterns. p38alpha and p38beta are ubiquitously expressed, p38gamma is predominantly found in skeletal muscle, and p38delta is found in the heart, lung, testis, pancreas, and small intestine. The p38 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143356 [Multi-domain]  Cd Length: 343  Bit Score: 59.23  E-value: 5.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdiMRDsnyiSKGSTFLPLKW-MAPESIFNSL-YTTLSD 885
Cdd:cd07851   125 YQILRGLKYIHSAGIIHRDLKPSNLAVNEDCELKILDFGLAR--HTD----DEMTGYVATRWyRAPEIMLNWMhYNQTVD 198
                          90       100
                  ....*....|....*....|....*..
gi 226342982  886 VWSFGILLWEIFTlGGTPYPELPMNDQ 912
Cdd:cd07851   199 IWSVGCIMAELLT-GKTLFPGSDHIDQ 224
PTZ00024 PTZ00024
cyclin-dependent protein kinase; Provisional
809-939 5.44e-09

cyclin-dependent protein kinase; Provisional


Pssm-ID: 240233 [Multi-domain]  Cd Length: 335  Bit Score: 59.00  E-value: 5.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLAR-----DIMRDS----------NYISKGSTflpLKWMAPE 873
Cdd:PTZ00024  127 QILNGLNVLHKWYFMHRDLSPANIFINSKGICKIADFGLARrygypPYSDTLskdetmqrreEMTSKVVT---LWYRAPE 203
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  874 SIFNS-LYTTLSDVWSFGILLWE-------------------IFTLGGTP----YPE---LPMNDQFYNAIKRGYRMAQP 926
Cdd:PTZ00024  204 LLMGAeKYHFAVDMWSVGCIFAElltgkplfpgeneidqlgrIFELLGTPnednWPQakkLPLYTEFTPRKPKDLKTIFP 283
                         170
                  ....*....|...
gi 226342982  927 aHASDEIYEIMQK 939
Cdd:PTZ00024  284 -NASDDAIDLLQS 295
STKc_Rad53_Cds1 cd14098
Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the ...
809-935 5.96e-09

Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Rad53 and Cds1 are the checkpoint kinase 2 (Chk2) homologs found in budding and fission yeast, respectively. They play a central role in the cell's response to DNA lesions to prevent genome rearrangements and maintain genome integrity. They are phosphorylated in response to DNA damage and incomplete replication, and are essential for checkpoint control. They help promote DNA repair by stalling the cell cycle prior to mitosis in the presence of DNA damage. The Rad53/Cds1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271000 [Multi-domain]  Cd Length: 265  Bit Score: 58.26  E-value: 5.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEG--KLVKICDFGLARDIMRDSNYISKGSTflpLKWMAPESIFNS------LY 880
Cdd:cd14098   109 QILEAMAYTHSMGITHRDLKPENILITQDdpVIVKISDFGLAKVIHTGTFLVTFCGT---MAYLAPEILMSKeqnlqgGY 185
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  881 TTLSDVWSFGILLWEIFTlGGTPYPElPMNDQFYNAIKRGyRMAQPAHASDEIYE 935
Cdd:cd14098   186 SNLVDMWSVGCLVYVMLT-GALPFDG-SSQLPVEKRIRKG-RYTQPPLVDFNISE 237
STKc_PKD cd14082
Catalytic domain of the Serine/Threonine kinase, Protein Kinase D; STKs catalyze the transfer ...
809-916 6.23e-09

Catalytic domain of the Serine/Threonine kinase, Protein Kinase D; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They contain N-terminal cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. The PKD subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270984 [Multi-domain]  Cd Length: 260  Bit Score: 58.19  E-value: 6.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGK---LVKICDFGLARDIMRDSNYISKGSTflPlKWMAPESIFNSLYTTLSD 885
Cdd:cd14082   111 QILVALRYLHSKNIVHCDLKPENVLLASAEpfpQVKLCDFGFARIIGEKSFRRSVVGT--P-AYLAPEVLRNKGYNRSLD 187
                          90       100       110
                  ....*....|....*....|....*....|...
gi 226342982  886 VWSFGILLWeiFTLGGT-PYPE-LPMNDQFYNA 916
Cdd:cd14082   188 MWSVGVIIY--VSLSGTfPFNEdEDINDQIQNA 218
STKc_Sty1_Hog1 cd07856
Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases ...
806-903 6.43e-09

Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs Sty1 from Schizosaccharomyces pombe, Hog1 from Saccharomyces cerevisiae, and similar proteins. Sty1 and Hog1 are stress-activated MAPKs that partipate in transcriptional regulation in response to stress. Sty1 is activated in response to oxidative stress, osmotic stress, and UV radiation. It is regulated by the MAP2K Wis1, which is activated by the MAP3Ks Wis4 and Win1, which receive signals of the stress condition from membrane-spanning histidine kinases Mak1-3. Activated Sty1 stabilizes the Atf1 transcription factor and induces transcription of Atf1-dependent genes of the core environmetal stress response. Hog1 is the key element in the high osmolarity glycerol (HOG) pathway and is activated upon hyperosmotic stress. Activated Hog1 accumulates in the nucleus and regulates stress-induced transcription. The HOG pathway is mediated by two transmembrane osmosensors, Sln1 and Sho1. MAPKs are important mediators of cellular responses to extracellular signals. The Sty1/Hog1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270843 [Multi-domain]  Cd Length: 328  Bit Score: 58.74  E-value: 6.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdiMRDSNYISKGSTFLplkWMAPESIFN-SLYTTLS 884
Cdd:cd07856   113 FLYQILRGLKYVHSAGVIHRDLKPSNILVNENCDLKICDFGLAR--IQDPQMTGYVSTRY---YRAPEIMLTwQKYDVEV 187
                          90
                  ....*....|....*....
gi 226342982  885 DVWSFGILLWEIftLGGTP 903
Cdd:cd07856   188 DIWSAGCIFAEM--LEGKP 204
STKc_RSK4_C cd14177
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called ...
808-911 7.13e-09

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK4 is also called S6K-alpha-6, RPS6KA6, p90RSK6 or pp90RSK4. RSK4 is a substrate of ERK and is a modulator of p53-dependent proliferation arrest in human cells. Deletion of the RSK4 gene, RPS6KA6, frequently occurs in patients of X-linked deafness type 3, mental retardation and choroideremia. Studies of RSK4 in cancer cells and tissues suggest that it may be oncogenic or tumor suppressive depending on many factors. RSK4 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271079 [Multi-domain]  Cd Length: 295  Bit Score: 58.49  E-value: 7.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICE----GKLVKICDFGLARDIMRDSnyiskGSTFLPL---KWMAPESIFNSLY 880
Cdd:cd14177   105 YTITKTVDYLHCQGVVHRDLKPSNILYMDdsanADSIRICDFGFAKQLRGEN-----GLLLTPCytaNFVAPEVLMRQGY 179
                          90       100       110
                  ....*....|....*....|....*....|.
gi 226342982  881 TTLSDVWSFGILLWEIFTlGGTPYPELPmND 911
Cdd:cd14177   180 DAACDIWSLGVLLYTMLA-GYTPFANGP-ND 208
STKc_Nek3 cd08219
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
809-949 7.33e-09

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek3 is primarily localized in the cytoplasm and shows no cell cycle-dependent changes in its activity. It is present in the axons of neurons and affects morphogenesis and polarity through its regulation of microtubule acetylation. Nek3 modulates the signaling of the prolactin receptor through its activation of Vav2 and contributes to prolactin-mediated motility of breast cancer cells. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173759 [Multi-domain]  Cd Length: 255  Bit Score: 58.06  E-value: 7.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrdSNYISKGSTFLPLKWMAPESIFNSL-YTTLSDVW 887
Cdd:cd08219   108 QMCLGVQHIHEKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLL---TSPGAYACTYVGTPYYVPPEIWENMpYNNKSDIW 184
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  888 SFGILLWEIFTLgGTPYPELPMNDQFYNAIKRGYRmAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd08219   185 SLGCILYELCTL-KHPFQANSWKNLILKVCQGSYK-PLPSHYSYELRSLIKQMFKRNPRSRP 244
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
221-309 7.57e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.66  E-value: 7.57e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982    221 QTVVRQGESITIRCIVMGNDVVNFQWTYPRmksGRLVEPVTDYLfGVPSRIGSILHIPTAELSDSGTYTCNVSvsvNDHG 300
Cdd:smart00410    3 SVTVKEGESVTLSCEASGSPPPEVTWYKQG---GKLLAESGRFS-VSRSGSTSTLTISNVTPEDSGTYTCAAT---NSSG 75
                            90
                    ....*....|
gi 226342982    301 DEKA-INISV 309
Cdd:smart00410   76 SASSgTTLTV 85
PK_eIF2AK_GCN2_rpt1 cd14012
Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or ...
805-893 8.40e-09

Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: GCN2, protein kinase regulated by RNA (PKR), heme-regulated inhibitor kinase (HRI), and PKR-like endoplasmic reticulum kinase (PERK). GCN2 is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kappaB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. The degenerate pseudokinase domain of GCN2 may function as a regulatory domain. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270914 [Multi-domain]  Cd Length: 254  Bit Score: 57.75  E-value: 8.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  805 GFSYQVANGMDFLASKNCVHRDLAARNVLI----CEGKlVKICDFGLARDImRDSNYISKGSTFLPLKWMAPESI-FNSL 879
Cdd:cd14012   108 RWTLQLLEALEYLHRNGVVHKSLHAGNVLLdrdaGTGI-VKLTDYSLGKTL-LDMCSRGSLDEFKQTYWLPPELAqGSKS 185
                          90
                  ....*....|....
gi 226342982  880 YTTLSDVWSFGILL 893
Cdd:cd14012   186 PTRKTDVWDLGLLF 199
STKc_NLK cd07853
Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer ...
806-896 8.52e-09

Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NLK is an atypical mitogen-activated protein kinase (MAPK) that is not regulated by a MAPK kinase. It functions downstream of the MAPK kinase kinase Tak1, which also plays a role in activating the JNK and p38 MAPKs. The Tak1/NLK pathways are regulated by Wnts, a family of secreted proteins that is critical in the control of asymmetric division and cell polarity. NLK can phosphorylate transcription factors from the TCF/LEF family, inhibiting their ability to activate the transcription of target genes. In prostate cancer cells, NLK is involved in regulating androgen receptor-mediated transcription and its expression is altered during cancer progression. MAPKs are important mediators of cellular responses to extracellular signals. The NLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173748 [Multi-domain]  Cd Length: 372  Bit Score: 58.99  E-value: 8.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLAR-DIMRDSNYISKgsTFLPLKWMAPESIFNSL-YTTL 883
Cdd:cd07853   108 FLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARvEEPDESKHMTQ--EVVTQYYRAPEILMGSRhYTSA 185
                          90
                  ....*....|...
gi 226342982  884 SDVWSFGILLWEI 896
Cdd:cd07853   186 VDIWSVGCIFAEL 198
STKc_Kin4 cd14076
Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the ...
601-922 8.75e-09

Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Kin4 is a central component of the spindle position checkpoint (SPOC), which monitors spindle position and regulates the mitotic exit network (MEN). Kin4 associates with spindle pole bodies in mother cells to inhibit MEN signaling and delay mitosis until the anaphase nucleus is properly positioned along the mother-bud axis. Kin4 activity is regulated by both the bud neck-associated kinase Elm1 and protein phosphatase 2A. The Kin4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270978 [Multi-domain]  Cd Length: 270  Bit Score: 57.88  E-value: 8.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  601 VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQA--LMSELKIMSHLGpHLNVVNLLGACTKGGPIY 678
Cdd:cd14076     4 ILGRTLGEGEFGKVKLGWPLPKANHRSGVQVAIKLIRRDTQQENCQTskIMREINILKGLT-HPNIVRLLDVLKTKKYIG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  679 IITEYCRYGDLVDYLHRNKHTflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmsKDesidyvpmldmk 758
Cdd:cd14076    83 IVLEFVSGGELFDYILARRRL---------------------------------------------KD------------ 105
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  759 gdikyadiespsymapydnyvpSAPERTYRatlindspvlsytdlvgfsyQVANGMDFLASKNCVHRDLAARNVLICEGK 838
Cdd:cd14076   106 ----------------------SVACRLFA--------------------QLISGVAYLHKKGVVHRDLKLENLLLDKNR 143
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  839 LVKICDFGLARDIMRDSNYISKGSTFLPLkWMAPESIF-NSLYT-TLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNa 916
Cdd:cd14076   144 NLVITDFGFANTFDHFNGDLMSTSCGSPC-YAAPELVVsDSMYAgRKADIWSCGVILYAMLA-GYLPFDDDPHNPNGDN- 220

                  ....*.
gi 226342982  917 IKRGYR 922
Cdd:cd14076   221 VPRLYR 226
STKc_CDK7 cd07841
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs ...
791-906 9.93e-09

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK7 plays essential roles in the cell cycle and in transcription. It associates with cyclin H and MAT1 and acts as a CDK-Activating Kinase (CAK) by phosphorylating and activating cell cycle CDKs (CDK1/2/4/6). In the brain, it activates CDK5. CDK7 is also a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of RNA polymerase II when it is bound with unphosphorylated DNA, as present in the pre-initiation complex. Following phosphorylation, the CTD dissociates from the DNA which allows transcription initiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270833 [Multi-domain]  Cd Length: 298  Bit Score: 57.97  E-value: 9.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  791 LIND-SPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDS-NYISKGSTflplK 868
Cdd:cd07841    91 VIKDkSIVLTPADIKSYMLMTLRGLEYLHSNWILHRDLKPNNLLIASDGVLKLADFGLARSFGSPNrKMTHQVVT----R 166
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 226342982  869 WM-APESIFNS-LYTTLSDVWSFGILLWE-------------------IFTLGGTPYPE 906
Cdd:cd07841   167 WYrAPELLFGArHYGVGVDMWSVGCIFAElllrvpflpgdsdidqlgkIFEALGTPTEE 225
STKc_myosinIIIB_N cd06639
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze ...
794-949 1.01e-08

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIB myosin is expressed highly in retina. It is also present in the brain and testis. The human class IIIB myosin gene maps to a region that overlaps the locus for Bardet-Biedl syndrome, which is characterized by dysmorphic extremities, retinal dystrophy, obesity, male hypogenitalism, and renal abnormalities. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. They may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. They may also function as cargo carriers during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270808 [Multi-domain]  Cd Length: 291  Bit Score: 58.08  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  794 DSPVLSYtdlvgFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIM--RDSNYISKGSTFlplkWMA 871
Cdd:cd06639   126 DEAMISY-----ILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTsaRLRRNTSVGTPF----WMA 196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  872 PESI-----FNSLYTTLSDVWSFGILLWEIFTlGGTPYPEL-PMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKF 945
Cdd:cd06639   197 PEVIaceqqYDYSYDARCDVWSLGITAIELAD-GDPPLFDMhPVKALFKIPRNPPPTLLNPEKWCRGFSHFISQCLIKDF 275

                  ....
gi 226342982  946 ETRP 949
Cdd:cd06639   276 EKRP 279
STKc_PAK6 cd06659
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the ...
816-919 1.03e-08

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK6 may play a role in stress responses through its activation by the mitogen-activated protein kinase (MAPK) p38 and MAPK kinase 6 (MKK6) pathway. PAK6 is highly expressed in the brain. It is not required for viability, but together with PAK5, it is required for normal levels of locomotion and activity, and for learning and memory. Increased expression of PAK6 is found in primary and metastatic prostate cancer. PAK6 may play a role in the regulation of motility. PAK6 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270821 [Multi-domain]  Cd Length: 297  Bit Score: 58.07  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  816 FLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDsnyISKGSTFLPLK-WMAPESIFNSLYTTLSDVWSFGILLW 894
Cdd:cd06659   132 YLHSQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKD---VPKRKSLVGTPyWMAPEVISRCPYGTEVDIWSLGIMVI 208
                          90       100
                  ....*....|....*....|....*
gi 226342982  895 EIFTlGGTPYpelpMNDQFYNAIKR 919
Cdd:cd06659   209 EMVD-GEPPY----FSDSPVQAMKR 228
STKc_ERK5 cd07855
Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; ...
806-896 1.04e-08

Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ERK5 (also called Big MAPK1 (BMK1) or MAPK7) has a unique C-terminal extension, making it approximately twice as big as other MAPKs. This extension contains transcriptional activation capability which is inhibited by the N-terminal half. ERK5 is activated in response to growth factors and stress by a cascade that leads to its phosphorylation by the MAP2K MEK5, which in turn is regulated by the MAP3Ks MEKK2 and MEKK3. Activated ERK5 phosphorylates its targets including myocyte enhancer factor 2 (MEF2), Sap1a, c-Myc, and RSK. It plays a role in EGF-induced cell proliferation during the G1/S phase transition. Studies on knockout mice revealed that ERK5 is essential for cardiovascular development and plays an important role in angiogenesis. It is also critical for neural differentiation and survival. The ERK5 pathway has been implicated in the pathogenesis of many diseases including cancer, cardiac hypertrophy, and atherosclerosis. MAPKs are important mediators of cellular responses to extracellular signals. The ERK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270842 [Multi-domain]  Cd Length: 336  Bit Score: 58.15  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDS----NYISKGSTFLPLKwmAPESIFnSL-- 879
Cdd:cd07855   114 FLYQLLRGLKYIHSANVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPeehkYFMTEYVATRWYR--APELML-SLpe 190
                          90
                  ....*....|....*..
gi 226342982  880 YTTLSDVWSFGILLWEI 896
Cdd:cd07855   191 YTQAIDMWSVGCIFAEM 207
STKc_Mnk1 cd14174
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase ...
810-903 1.16e-08

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271076 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLiCEGK----LVKICDFGLARDIMRDS--NYISKGSTFLPL---KWMAPE--SIFN- 877
Cdd:cd14174   109 IASALDFLHTKGIAHRDLKPENIL-CESPdkvsPVKICDFDLGSGVKLNSacTPITTPELTTPCgsaEYMAPEvvEVFTd 187
                          90       100
                  ....*....|....*....|....*...
gi 226342982  878 --SLYTTLSDVWSFGILLWeiFTLGGTP 903
Cdd:cd14174   188 eaTFYDKRCDLWSLGVILY--IMLSGYP 213
STKc_p38gamma cd07880
Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase ...
808-898 1.31e-08

Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38gamma/MAPK12 is predominantly expressed in skeletal muscle. Unlike p38alpha and p38beta, p38gamma is insensitive to pyridinylimidazoles. It displays an antagonizing function compared to p38alpha. p38gamma inhibits, while p38alpha stimulates, c-Jun phosphorylation and AP-1 mediated transcription. p38gamma also plays a role in the signaling between Ras and the estrogen receptor and has been implicated to increase cell invasion and breast cancer progression. In Xenopus, p38gamma is critical in the meiotic maturation of oocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143385 [Multi-domain]  Cd Length: 343  Bit Score: 58.04  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrDSNYiskgSTFLPLKWM-APESIFNSL-YTTLSD 885
Cdd:cd07880   125 YQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQT--DSEM----TGYVVTRWYrAPEVILNWMhYTQTVD 198
                          90
                  ....*....|...
gi 226342982  886 VWSFGILLWEIFT 898
Cdd:cd07880   199 IWSVGCIMAEMLT 211
STKc_MLCK-like cd14006
Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs ...
790-892 1.32e-08

Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This family is composed of MLCKs and related MLCK-like kinase domains from giant STKs such as titin, obscurin, SPEG, Unc-89, Trio, kalirin, and Twitchin. Also included in this family are Death-Associated Protein Kinases (DAPKs) and Death-associated protein kinase-Related Apoptosis-inducing protein Kinase (DRAKs). MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. Titin, obscurin, Twitchin, and SPEG are muscle proteins involved in the contractile apparatus. The giant STKs are multidomain proteins containing immunoglobulin (Ig), fibronectin type III (FN3), SH3, RhoGEF, PH and kinase domains. Titin, obscurin, Twitchin, and SPEG contain many Ig domain repeats at the N-terminus, while Trio and Kalirin contain spectrin-like repeats. The MLCK-like family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270908 [Multi-domain]  Cd Length: 247  Bit Score: 56.89  E-value: 1.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  790 TLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGK--LVKICDFGLARDIMRDSNyisKGSTFLPL 867
Cdd:cd14006    78 DRLAERGSLSEEEVRTYMRQLLEGLQYLHNHHILHLDLKPENILLADRPspQIKIIDFGLARKLNPGEE---LKEIFGTP 154
                          90       100
                  ....*....|....*....|....*
gi 226342982  868 KWMAPESIFNSLYTTLSDVWSFGIL 892
Cdd:cd14006   155 EFVAPEIVNGEPVSLATDMWSIGVL 179
STKc_ASK cd06624
Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs ...
791-953 1.39e-08

Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily are mitogen-activated protein kinase (MAPK) kinase kinases (MAPKKKs or MKKKs) and include ASK1, ASK2, and MAPKKK15. ASK1 (also called MAPKKK5) functions in the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. It plays important roles in cytokine and stress responses, as well as in reactive oxygen species-mediated cellular responses. ASK1 is implicated in various diseases mediated by oxidative stress including inschemic heart disease, hypertension, vessel injury, brain ischemia, Fanconi anemia, asthma, and pulmonary edema, among others. ASK2 (also called MAPKKK6) functions only in a heteromeric complex with ASK1, and can activate ASK1 by direct phosphorylation. The function of MAPKKK15 is still unknown. The ASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270794 [Multi-domain]  Cd Length: 268  Bit Score: 57.03  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  791 LINDSPVLSYtdlvgFSYQVANGMDFLASKNCVHRDLAARNVLI-CEGKLVKICDFGLARdimRDSNYISKGSTFL-PLK 868
Cdd:cd06624   103 LKDNENTIGY-----YTKQILEGLKYLHDNKIVHRDIKGDNVLVnTYSGVVKISDFGTSK---RLAGINPCTETFTgTLQ 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  869 WMAPESIFNSL--YTTLSDVWSFGILLWEIFTlGGTPYPEL--PMNDQFynaiKRG-YRMAQ--PAHASDEIYEIMQKCW 941
Cdd:cd06624   175 YMAPEVIDKGQrgYGPPADIWSLGCTIIEMAT-GKPPFIELgePQAAMF----KVGmFKIHPeiPESLSEEAKSFILRCF 249
                         170
                  ....*....|..
gi 226342982  942 EEKFETRPPFSQ 953
Cdd:cd06624   250 EPDPDKRATASD 261
STKc_RSK3_C cd14178
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called ...
810-908 1.46e-08

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK3 is also called S6K-alpha-2, RPS6KA2, p90RSK2 or MAPK-activated protein kinase 1c (MAPKAPK-1c). RSK3 binds muscle A-kinase anchoring protein (mAKAP)-b directly and regulates concentric cardiac myocyte growth. The RSK3 gene, RPS6KA2, is a putative tumor suppressor gene in sporadic epithelial ovarian cancer and variations to the gene may be associated with rectal cancer risk. RSK3 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271080 [Multi-domain]  Cd Length: 293  Bit Score: 57.33  E-value: 1.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLICEG----KLVKICDFGLARDiMRDSNyiskGSTFLPL---KWMAPESIFNSLYTT 882
Cdd:cd14178   106 ITKTVEYLHSQGVVHRDLKPSNILYMDEsgnpESIRICDFGFAKQ-LRAEN----GLLMTPCytaNFVAPEVLKRQGYDA 180
                          90       100
                  ....*....|....*....|....*.
gi 226342982  883 LSDVWSFGILLWEIFTlGGTPYPELP 908
Cdd:cd14178   181 ACDIWSLGILLYTMLA-GFTPFANGP 205
STKc_SRPK cd14136
Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze ...
807-898 1.51e-08

Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SRPKs phosphorylate and regulate splicing factors from the SR protein family by specifically phosphorylating multiple serine residues residing in SR/RS dipeptide motifs (also known as RS domains). Phosphorylation of the RS domains enhances interaction with transportin SR and facilitates entry of the SR proteins into the nucleus. SRPKs contain a nonconserved insert domain, within the well-conserved catalytic kinase domain, that regulates their subcellular localization. They play important roles in mediating pre-mRNA processing and mRNA maturation, as well as other cellular functions such as chromatin reorganization, cell cycle and p53 regulation, and metabolic signaling. Vertebrates contain three distinct SRPKs, called SRPK1-3. The SRPK homolog in budding yeast, Sky1p, recognizes and phosphorylates its substrate Npl3p, which lacks a classic RS domain but contains a single RS dipeptide at the C-terminus of its RGG domain. Npl3p is a shuttling heterogeneous nuclear ribonucleoprotein (hnRNP) that exports a distinct class of mRNA from the nucleus to the cytoplasm. The SRPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271038 [Multi-domain]  Cd Length: 320  Bit Score: 57.59  E-value: 1.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  807 SYQVANGMDFLASKnC--VHRDLAARNVLICEGKL-VKICDFGlardimrDSNYISKGST--FLPLKWMAPESIFNSLYT 881
Cdd:cd14136   125 ARQVLQGLDYLHTK-CgiIHTDIKPENVLLCISKIeVKIADLG-------NACWTDKHFTedIQTRQYRSPEVILGAGYG 196
                          90
                  ....*....|....*..
gi 226342982  882 TLSDVWSFGILLWEIFT 898
Cdd:cd14136   197 TPADIWSTACMAFELAT 213
STKc_MEKK4 cd06626
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
806-953 1.53e-08

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK4 is a MAPK kinase kinase that phosphorylates and activates the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. MEKK4 also plays roles in the re-polarization of the actin cytoskeleton in response to osmotic stress, in the proper closure of the neural tube, in cardiovascular development, and in immune responses. The MEKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270796 [Multi-domain]  Cd Length: 265  Bit Score: 56.93  E-value: 1.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdimrdsnYISKGSTFLPLK----------WMAPESI 875
Cdd:cd06626   104 YTLQLLEGLAYLHENGIVHRDIKPANIFLDSNGLIKLGDFGSAV-------KLKNNTTTMAPGevnslvgtpaYMAPEVI 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  876 FNSL---YTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRMAQPAH--ASDEIYEIMQKCWEEKFETRPP 950
Cdd:cd06626   177 TGNKgegHGRAADIWSLGCVVLEMAT-GKRPWSELDNEWAIMYHVGMGHKPPIPDSlqLSPEGKDFLSRCLESDPKKRPT 255

                  ...
gi 226342982  951 FSQ 953
Cdd:cd06626   256 ASE 258
STKc_Nek7 cd08229
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
809-949 1.57e-08

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek7 is required for mitotic spindle formation and cytokinesis. It is enriched in the centrosome and is critical for microtubule nucleation. Nek7 is activated by Nek9 during mitosis, and may regulate the p70 ribosomal S6 kinase. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270866 [Multi-domain]  Cd Length: 292  Bit Score: 57.35  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdiMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWS 888
Cdd:cd08229   136 QLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGR--FFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWS 213
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  889 FGILLWEIFTLgGTPYPELPMNdqFYNAIKRGYRMAQPA----HASDEIYEIMQKCWEEKFETRP 949
Cdd:cd08229   214 LGCLLYEMAAL-QSPFYGDKMN--LYSLCKKIEQCDYPPlpsdHYSEELRQLVNMCINPDPEKRP 275
STKc_MEKK2 cd06652
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
806-949 1.79e-08

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK2 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK2 also activates ERK1/2, c-Jun N-terminal kinase (JNK) and p38 through their respective MAPKKs MEK1/2, JNK-activating kinase 2 (JNKK2), and MKK3/6. MEKK2 plays roles in T cell receptor signaling, immune synapse formation, cytokine gene expression, as well as in EGF and FGF receptor signaling. The MEKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270818 [Multi-domain]  Cd Length: 264  Bit Score: 56.98  E-value: 1.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRD--SNYISKGSTFLPLkWMAPESIFNSLYTTL 883
Cdd:cd06652   111 YTRQILEGVHYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASKRLQTIclSGTGMKSVTGTPY-WMSPEVISGEGYGRK 189
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226342982  884 SDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKfETRP 949
Cdd:cd06652   190 ADIWSVGCTVVEMLT-EKPPWAEFEAMAAIFKIATQPTNPQLPAHVSDHCRDFLKRIFVEA-KLRP 253
STKc_TSSK6-like cd14164
Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs ...
809-906 1.90e-08

Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK6, also called SSTK, is expressed at the head of elongated sperm. It can phosphorylate histones and associate with heat shock protens HSP90 and HSC70. Male mice deficient in TSSK6 are infertile, showing spermatogenic impairment including reduced sperm counts, impaired DNA condensation, abnormal morphology and decreased motility rates. The TSSK6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271066 [Multi-domain]  Cd Length: 256  Bit Score: 56.79  E-value: 1.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLIC-EGKLVKICDFGLARDImrdSNYISKGSTFLPLK-WMAPESIFNSLYTTLS-D 885
Cdd:cd14164   108 QMVGAVNYLHDMNIVHRDLKCENILLSaDDRKIKIADFGFARFV---EDYPELSTTFCGSRaYTPPEVILGTPYDPKKyD 184
                          90       100
                  ....*....|....*....|.
gi 226342982  886 VWSFGILLWEIFTlGGTPYPE 906
Cdd:cd14164   185 VWSLGVVLYVMVT-GTMPFDE 204
STKc_BMPR1 cd14144
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; ...
797-941 2.19e-08

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1 functions as a receptor for morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Vertebrates contain two type I BMP receptors, BMPR1a and BMPR1b. BMPR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that also includes TGFbeta, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271046 [Multi-domain]  Cd Length: 287  Bit Score: 56.72  E-value: 2.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  797 VLSYTDLVGFSYQVANGMDFLASKNC--------VHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYI--SKGSTFLP 866
Cdd:cd14144    88 TLDTQSMLKLAYSAACGLAHLHTEIFgtqgkpaiAHRDIKSKNILVKKNGTCCIADLGLAVKFISETNEVdlPPNTRVGT 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  867 LKWMAPESIFNSLYTT------LSDVWSFGILLWEIF---TLGGT------PYPELPMNDQFYNAIKR-----GYRMAQP 926
Cdd:cd14144   168 KRYMAPEVLDESLNRNhfdaykMADMYSFGLVLWEIArrcISGGIveeyqlPYYDAVPSDPSYEDMRRvvcveRRRPSIP 247
                         170       180
                  ....*....|....*....|
gi 226342982  927 AH-ASDEIY----EIMQKCW 941
Cdd:cd14144   248 NRwSSDEVLrtmsKLMSECW 267
STKc_EIF2AK1_HRI cd14049
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
808-902 2.40e-08

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HRI (or EIF2AK1) contains an N-terminal regulatory heme-binding domain and a C-terminal catalytic kinase domain. It is suppressed under normal conditions by binding of the heme iron, and is activated during heme deficiency. It functions as a critical regulator that ensures balanced synthesis of globins and heme, in order to form stable hemoglobin during erythroid differentiation and maturation. HRI also protects cells and enhances survival under iron-deficient conditions. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The HRI subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270951 [Multi-domain]  Cd Length: 284  Bit Score: 56.75  E-value: 2.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKL-VKICDFGLA-RDIMRDS---------NYISKGSTFLPLKWMAPESIF 876
Cdd:cd14049   127 QQLLEGVTYIHSMGIVHRDLKPRNIFLHGSDIhVRIGDFGLAcPDILQDGndsttmsrlNGLTHTSGVGTCLYAAPEQLE 206
                          90       100
                  ....*....|....*....|....*.
gi 226342982  877 NSLYTTLSDVWSFGILLWEIFTLGGT 902
Cdd:cd14049   207 GSHYDFKSDMYSIGVILLELFQPFGT 232
PK_GC-2D cd14043
Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D; The pseudokinase domain ...
813-953 2.45e-08

Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity and/or ATP binding. GC-2D is allso called Retinal Guanylyl Cyclase 1 (RETGC-1) or Rod Outer Segment membrane Guanylate Cyclase (ROS-GC). It is found in the photoreceptors of the retina where it anchors the reciprocal feedback loop between calcium and cGMP, which regulates the dark, light, and recovery phases in phototransduction. It is also found in other sensory neurons and may be a universal transduction component that plays a role in the perception of all senses. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC-2D subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270945 [Multi-domain]  Cd Length: 267  Bit Score: 56.26  E-value: 2.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  813 GMDFLASKNCVHRDLAARNVLIcEGKLV-KICDFGLArDIMRDSNYISKGSTFLPLKWMAPESIFNSLY----TTLSDVW 887
Cdd:cd14043   109 GMRYLHHRGIVHGRLKSRNCVV-DGRFVlKITDYGYN-EILEAQNLPLPEPAPEELLWTAPELLRDPRLerrgTFPGDVF 186
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226342982  888 SFGILLWEIFTLGGtPYPELPMN-DQFYNAIKRGYRMAQPAHASD----EIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14043   187 SFAIIMQEVIVRGA-PYCMLGLSpEEIIEKVRSPPPLCRPSVSMDqaplECIQLMKQCWSEAPERRPTFDQ 256
STKc_SPEG_rpt2 cd14111
Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle ...
799-907 2.58e-08

Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Striated muscle preferentially expressed gene (SPEG) generates 4 different isoforms through alternative promoter use and splicing in a tissue-specific manner: SPEGalpha and SPEGbeta are expressed in cardiac and skeletal striated muscle; Aortic Preferentially Expressed Protein-1 (APEG-1) is expressed in vascular smooth muscle; and Brain preferentially expressed gene (BPEG) is found in the brain and aorta. SPEG proteins have mutliple immunoglobulin (Ig), 2 fibronectin type III (FN3), and two kinase domains. They are necessary for cardiac development and survival. The SPEG subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271013 [Multi-domain]  Cd Length: 257  Bit Score: 56.37  E-value: 2.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  799 SYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrdsNYIS---KGSTFLPLKWMAPESI 875
Cdd:cd14111    97 SEDDVVGYLVQILQGLEYLHGRRVLHLDIKPDNIMVTNLNAIKIVDFGSAQSF----NPLSlrqLGRRTGTLEYMAPEMV 172
                          90       100       110
                  ....*....|....*....|....*....|..
gi 226342982  876 FNSLYTTLSDVWSFGILLWeIFTLGGTPYPEL 907
Cdd:cd14111   173 KGEPVGPPADIWSIGVLTY-IMLSGRSPFEDQ 203
PKc_MEK cd06615
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
807-937 2.66e-08

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 and MEK2 are MAPK kinases (MAPKKs or MKKs), and are dual-specificity PKs that phosphorylate and activate the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1/2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. This cascade has also been implicated in synaptic plasticity, migration, morphological determination, and stress response immunological reactions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1/2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132946 [Multi-domain]  Cd Length: 308  Bit Score: 56.68  E-value: 2.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  807 SYQVANGMDFLASK-NCVHRDLAARNVLICEGKLVKICDFGLARDIMRdsnyiSKGSTFLPLK-WMAPESIFNSLYTTLS 884
Cdd:cd06615   105 SIAVLRGLTYLREKhKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-----SMANSFVGTRsYMSPERLQGTHYTVQS 179
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  885 DVWSFGILLWEIfTLGGTPYP-----EL-PMNDQFYNAIKRGYRMAQPA-HASDE-----IYEIM 937
Cdd:cd06615   180 DIWSLGLSLVEM-AIGRYPIPppdakELeAMFGRPVSEGEAKESHRPVSgHPPDSprpmaIFELL 243
IgI_4_SCFR_like cd04975
Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR), and similar ...
335-413 2.90e-08

Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR), and similar domains; member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR). In addition to SCFR, this group also includes the fourth Ig domain of macrophage colony stimulating factor receptor (M-CSF-R). SCFR, also called receptor tyrosine kinase KIT or proto-oncogene c-Kit, contains an extracellular component having five Ig-like domains, a transmembrane segment, and a cytoplasmic portion having protein tyrosine kinase activity. SCFR and its ligand SCF are critical for normal hematopoiesis, mast cell development, melanocytes, and gametogenesis. SCF binds to the second and third Ig-like domains of SCFR, this fourth Ig-like domain participates in SCFR dimerization, which follows ligand binding. Deletion of this fourth SCFR Ig-like domain abolishes the ligand-induced dimerization of SCFR and completely inhibits signal transduction. M-CSF-R, also called proto-oncogene c-Fms, acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, such as macrophages and monocytes. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409364  Cd Length: 101  Bit Score: 52.61  E-value: 2.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  335 LRVVFEAYPMPSVL-WLKDNRTLGDSGagELVLSTRNMSETRYVSELILVRVKVSEAGYYTMRAFHEDDEVQLSFKLQVN 413
Cdd:cd04975    23 LIVEVEAYPKPEHQnWTYMGPFFTDKW--EDLPNSENESTYRYVSTLHLTRLKGSEAGTYTFLASNSDVNAALAFEVYLN 100
STKc_CDC2L1 cd07843
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze ...
808-939 2.90e-08

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L1, also called PITSLRE, exists in different isoforms which are named using the alias CDK11(p). The CDC2L1 gene produces two protein products, CDK11(p110) and CDK11(p58). CDC2L1 is also represented by the caspase-processed CDK11(p46). CDK11(p110), the major isoform, associates with cyclin L and is expressed throughout the cell cycle. It is involved in RNA processing and the regulation of transcription. CDK11(p58) associates with cyclin D3 and is expressed during the G2/M phase of the cell cycle. It plays roles in spindle morphogenesis, centrosome maturation, sister chromatid cohesion, and the completion of mitosis. CDK11(p46) is formed from the larger isoforms by caspases during TNFalpha- and Fas-induced apoptosis. It functions as a downstream effector kinase in apoptotic signaling pathways and interacts with eukaryotic initiation factor 3f (eIF3f), p21-activated kinase (PAK1), and Ran-binding protein (RanBPM). CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173741 [Multi-domain]  Cd Length: 293  Bit Score: 56.46  E-value: 2.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrdsnyiskGStflPLKWM----------APESIFN 877
Cdd:cd07843   113 LQLLSGVAHLHDNWILHRDLKTSNLLLNNRGILKICDFGLAREY---------GS---PLKPYtqlvvtlwyrAPELLLG 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  878 -SLYTTLSDVWSFGILLWE-------------------IFTLGGTP-------YPELP------MNDQFYNAIKRGYrma 924
Cdd:cd07843   181 aKEYSTAIDMWSVGCIFAElltkkplfpgkseidqlnkIFKLLGTPtekiwpgFSELPgakkktFTKYPYNQLRKKF--- 257
                         170
                  ....*....|....*
gi 226342982  925 QPAHASDEIYEIMQK 939
Cdd:cd07843   258 PALSLSDNGFDLLNR 272
STKc_PCTAIRE2 cd07872
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer ...
797-915 2.93e-08

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-2 is specifically expressed in neurons in the central nervous system, mainly in terminally differentiated neurons. It associates with Trap (Tudor repeat associator with PCTAIRE-2) and could play a role in regulating mitochondrial function in neurons. PCTAIRE-2 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143377 [Multi-domain]  Cd Length: 309  Bit Score: 56.54  E-value: 2.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  797 VLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLplkWMAPESIF 876
Cdd:cd07872   100 IMSMHNVKIFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTL---WYRPPDVL 176
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226342982  877 --NSLYTTLSDVWSFGILLWE-------------------IFTLGGTP----YPELPMNDQFYN 915
Cdd:cd07872   177 lgSSEYSTQIDMWGVGCIFFEmasgrplfpgstvedelhlIFRLLGTPteetWPGISSNDEFKN 240
STKc_PCTAIRE3 cd07871
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer ...
806-926 3.00e-08

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-3 shows a restricted pattern of expression and is present in brain, kidney, and intestine. It is elevated in Alzheimer's disease (AD) and has been shown to associate with paired helical filaments (PHFs) and stimulate Tau phosphorylation. As AD progresses, phosphorylated Tau aggregates and forms PHFs, which leads to the formation of neurofibrillary tangles. In human glioma cells, PCTAIRE-3 induces cell cycle arrest and cell death. PCTAIRE-3 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270853 [Multi-domain]  Cd Length: 288  Bit Score: 56.56  E-value: 3.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLplkWMAPESIF--NSLYTTL 883
Cdd:cd07871   108 FMFQLLRGLSYCHKRKILHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTL---WYRPPDVLlgSTEYSTP 184
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226342982  884 SDVWSFGILLWE-------------------IFTLGGTP----YPELPMNDQFYNAIKRGYRmAQP 926
Cdd:cd07871   185 IDMWGVGCILYEmatgrpmfpgstvkeelhlIFRLLGTPteetWPGVTSNEEFRSYLFPQYR-AQP 249
STKc_GAK_like cd13985
Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of ...
604-949 3.13e-08

Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes cyclin G-Associated Kinase (GAK), Drosophila melanogaster Numb-Associated Kinase (NAK)-like proteins, and similar protein kinases. GAK plays regulatory roles in clathrin-mediated membrane trafficking, the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses. NAK plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. The GAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270887 [Multi-domain]  Cd Length: 272  Bit Score: 56.19  E-value: 3.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEATAHGLSHSqatmkVAVKMLKSTARSSEKQAlMSELKIMSHLGPHLNVVNLLGACTKGGP----IYI 679
Cdd:cd13985     6 KQLGEGGFSYVYLAHDVNTGRR-----YALKRMYFNDEEQLRVA-IKEIEIMKRLCGHPNIVQYYDSAILSSEgrkeVLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  680 ITEYCRyGDLVDYLhrnkhtflqrhsnkhcppsaelySNALPVGFSlpshlnltgesdggymdmskdesidyvpmldmkg 759
Cdd:cd13985    80 LMEYCP-GSLVDIL-----------------------EKSPPSPLS---------------------------------- 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  760 dikyadiespsymapydnyvpsapERTyratlindspvlsytdLVGFSYQVANGMDFLASKN--CVHRDLAARNVLICEG 837
Cdd:cd13985   102 ------------------------EEE----------------VLRIFYQICQAVGHLHSQSppIIHRDIKIENILFSNT 141
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  838 KLVKICDFGLARDI-----------MRDSNyISKGSTflpLKWMAPESIfnSLY-----TTLSDVWSFGILLWEIFTLgG 901
Cdd:cd13985   142 GRFKLCDFGSATTEhypleraeevnIIEEE-IQKNTT---PMYRAPEMI--DLYskkpiGEKADIWALGCLLYKLCFF-K 214
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 226342982  902 TPY-PELPMNDQFYNaikrgYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd13985   215 LPFdESSKLAIVAGK-----YSIPEQPRYSPELHDLIRHMLTPDPAERP 258
STKc_CDK2_3 cd07860
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; ...
806-898 3.16e-08

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. CDK2, together with CDK4, also regulates embryonic cell proliferation. Despite these important roles, mice deleted for the cdk2 gene are viable and normal except for being sterile. This may be due to compensation provided by CDK1 (also called Cdc2), which can also bind cyclin E and drive the G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270844 [Multi-domain]  Cd Length: 284  Bit Score: 56.36  E-value: 3.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI---MRdsNYISKGSTflpLKWMAPESIFNS-LYT 881
Cdd:cd07860   105 YLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFgvpVR--TYTHEVVT---LWYRAPEILLGCkYYS 179
                          90
                  ....*....|....*..
gi 226342982  882 TLSDVWSFGILLWEIFT 898
Cdd:cd07860   180 TAVDIWSLGCIFAEMVT 196
STKc_RSK1_C cd14175
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called ...
598-908 3.55e-08

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK1 is also called S6K-alpha-1, RPS6KA1, p90RSK1 or MAPK-activated protein kinase 1a (MAPKAPK-1a). It is a component of the insulin transduction pathway, regulating the function of IRS1. It also interacts with PKA and promotes its inactivation. RSK1 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271077 [Multi-domain]  Cd Length: 291  Bit Score: 56.19  E-value: 3.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  598 DQLVLGRTLGSGAFGQVVEATahglsHSQATMKVAVKMLKSTARSSEKqalmsELKIMSHLGPHLNVVNLLGACTKGGPI 677
Cdd:cd14175     1 DGYVVKETIGVGSYSVCKRCV-----HKATNMEYAVKVIDKSKRDPSE-----EIEILLRYGQHPNIITLKDVYDDGKHV 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  678 YIITEYCRYGDLVDYLHRNKHtflqrhsnkhcppsaelysnalpvgFSlpshlnltgesdggymdmskdesidyvpmldm 757
Cdd:cd14175    71 YLVTELMRGGELLDKILRQKF-------------------------FS-------------------------------- 93
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  758 kgdikyadiespsymapydnyvpsapERTYRATLindspvlsytdlvgfsYQVANGMDFLASKNCVHRDLAARNVLICEG 837
Cdd:cd14175    94 --------------------------EREASSVL----------------HTICKTVEYLHSQGVVHRDLKPSNILYVDE 131
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  838 ----KLVKICDFGLARDIMRDSnyiskGSTFLPL---KWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELP 908
Cdd:cd14175   132 sgnpESLRICDFGFAKQLRAEN-----GLLMTPCytaNFVAPEVLKRQGYDEGCDIWSLGILLYTMLA-GYTPFANGP 203
STKc_Nek6 cd08228
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
809-952 3.70e-08

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 is required for the transition from metaphase to anaphase. It also plays important roles in mitotic spindle formation and cytokinesis. Activated by Nek9 during mitosis, Nek6 phosphorylates Eg5, a kinesin that is important for spindle bipolarity. Nek6 localizes to spindle microtubules during metaphase and anaphase, and to the midbody during cytokinesis. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270865 [Multi-domain]  Cd Length: 268  Bit Score: 55.80  E-value: 3.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdiMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWS 888
Cdd:cd08228   114 QLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGR--FFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWS 191
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  889 FGILLWEIFTLgGTPYPELPMNdqFYNAIKRGYRMAQPA----HASDEIYEIMQKCWEEKFETRPPFS 952
Cdd:cd08228   192 LGCLLYEMAAL-QSPFYGDKMN--LFSLCQKIEQCDYPPlpteHYSEKLRELVSMCIYPDPDQRPDIG 256
PTK_Jak3_rpt1 cd14208
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 3; Jak3 is ...
809-951 4.01e-08

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 3; Jak3 is expressed only in hematopoietic cells. It binds the shared receptor subunit, common gamma chain and thus, is essential in the signaling of cytokines that use it such as IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Jak3 is important in lymphoid development and myeloid cell differentiation. Inactivating mutations in Jak3 have been reported in humans with severe combined immunodeficiency (SCID). Jak3 is a cytoplasmic (or nonreceptor) PTK containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. It modulates the kinase activity of the C-terminal catalytic domain. Jaks are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Jak3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271110 [Multi-domain]  Cd Length: 260  Bit Score: 55.68  E-value: 4.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLIC-EGK-----LVKICDFGLARDIMRDSNYISKgstflpLKWMAPESIFNSLYTT 882
Cdd:cd14208   112 QLAYALNYLEDKQLVHGNVSAKKVLLSrEGDkgsppFIKLSDPGVSIKVLDEELLAER------IPWVAPECLSDPQNLA 185
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  883 L-SDVWSFGILLWEIFTLGGTPYPEL-PMND-QFYNAikrgyRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd14208   186 LeADKWGFGATLWEIFSGGHMPLSALdPSKKlQFYND-----RKQLPAPHWIELASLIQQCMSYNPLLRPSF 252
STKc_TNIK cd06637
Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs ...
809-953 4.04e-08

Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TNIK is an effector of Rap2, a small GTP-binding protein from the Ras family. TNIK specifically activates the c-Jun N-terminal kinase (JNK) pathway and plays a role in regulating the actin cytoskeleton. The TNIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270807 [Multi-domain]  Cd Length: 296  Bit Score: 56.27  E-value: 4.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDsnyISKGSTFLPLK-WMAPESIF-----NSLYTT 882
Cdd:cd06637   119 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT---VGRRNTFIGTPyWMAPEVIAcdenpDATYDF 195
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  883 LSDVWSFGILLWEIfTLGGTPYPEL-PMNDQFYNAIKRGYRMaQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd06637   196 KSDLWSLGITAIEM-AEGAPPLCDMhPMRALFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPSTEQ 265
STKc_TSSK1_2-like cd14165
Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; ...
808-904 4.34e-08

Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK2 is localized in the sperm neck, equatorial segment, and mid-piece of the sperm tail. Both TSSK1 and TSSK2 phosphorylate their common substrate TSKS (testis-specific-kinase-substrate). TSSK1/TSSK2 double knock-out mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271067 [Multi-domain]  Cd Length: 263  Bit Score: 55.56  E-value: 4.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSN-YISKGSTFL-PLKWMAPESIFNSLYT-TLS 884
Cdd:cd14165   109 HQLSSAIKYCHELDIVHRDLKCENLLLDKDFNIKLTDFGFSKRCLRDENgRIVLSKTFCgSAAYAAPEVLQGIPYDpRIY 188
                          90       100
                  ....*....|....*....|
gi 226342982  885 DVWSFGILLWeIFTLGGTPY 904
Cdd:cd14165   189 DIWSLGVILY-IMVCGSMPY 207
STKc_CDK12 cd07864
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs ...
806-898 4.42e-08

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK12 is also called Cdc2-related protein kinase 7 (CRK7) or Cdc2-related kinase arginine/serine-rich (CrkRS). It is a unique CDK that contains an RS domain, which is predominantly found in splicing factors. CDK12 is widely expressed in tissues. It interacts with cyclins L1 and L2, and plays roles in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK12 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270847 [Multi-domain]  Cd Length: 302  Bit Score: 55.96  E-value: 4.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSN--YISKGSTFlplkWMAPESIF--NSLYT 881
Cdd:cd07864   121 FMKQLLEGLNYCHKKNFLHRDIKCSNILLNNKGQIKLADFGLARLYNSEESrpYTNKVITL----WYRPPELLlgEERYG 196
                          90
                  ....*....|....*..
gi 226342982  882 TLSDVWSFGILLWEIFT 898
Cdd:cd07864   197 PAIDVWSCGCILGELFT 213
STKc_CDK5 cd07839
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs ...
806-912 4.72e-08

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK5 is unusual in that it is regulated by non-cyclin proteins, p35 and p39. It is highly expressed in the nervous system and is critical in normal neural development and function. It plays a role in neuronal migration and differentiation, and is also important in synaptic plasticity and learning. CDK5 also participates in protecting against cell death and promoting angiogenesis. Impaired CDK5 activity is implicated in Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease and acute neuronal injury. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143344 [Multi-domain]  Cd Length: 284  Bit Score: 55.90  E-value: 4.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI---MRdsnyiSKGSTFLPLKWMAPESIFNS-LYT 881
Cdd:cd07839   104 FMFQLLKGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFgipVR-----CYSAEVVTLWYRPPDVLFGAkLYS 178
                          90       100       110
                  ....*....|....*....|....*....|.
gi 226342982  882 TLSDVWSFGILLWEIFTLGGTPYPELPMNDQ 912
Cdd:cd07839   179 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQ 209
STKc_Rim15_like cd05611
Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the ...
789-920 4.82e-08

Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include Saccharomyces cerevisiae Rim15, Schizosaccharomyces pombe cek1, and similar fungal proteins. They contain a central catalytic domain, which contains an insert relative to MAST kinases. In addition, Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. Rim15 (or Rim15p) functions as a regulator of meiosis. It acts as a downstream effector of PKA and regulates entry into stationary phase (G0). Thus, it plays a crucial role in regulating yeast proliferation, differentiation, and aging. Cek1 may facilitate progression of mitotic anaphase. The Rim15-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270762 [Multi-domain]  Cd Length: 263  Bit Score: 55.56  E-value: 4.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  789 ATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARD-IMRDSNYISKGSTflpl 867
Cdd:cd05611    85 ASLIKTLGGLPEDWAKQYIAEVVLGVEDLHQRGIIHRDIKPENLLIDQTGHLKLTDFGLSRNgLEKRHNKKFVGTP---- 160
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 226342982  868 KWMAPESIFNSLYTTLSDVWSFGILLWEIFTlgGTPYPELPMNDQFYNAIKRG 920
Cdd:cd05611   161 DYLAPETILGVGDDKMSDWWSLGCVIFEFLF--GYPPFHAETPDAVFDNILSR 211
STKc_PRKX_like cd05612
Catalytic domain of PRKX-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of ...
806-903 5.92e-08

Catalytic domain of PRKX-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include human PRKX (X chromosome-encoded protein kinase), Drosophila DC2, and similar proteins. PRKX is present in many tissues including fetal and adult brain, kidney, and lung. The PRKX gene is located in the Xp22.3 subregion and has a homolog called PRKY on the Y chromosome. An abnormal interchange between PRKX aand PRKY leads to the sex reversal disorder of XX males and XY females. PRKX is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PRKX-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270763 [Multi-domain]  Cd Length: 292  Bit Score: 55.52  E-value: 5.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImRDSNYISKGSTflplKWMAPESIFNSLYTTLSD 885
Cdd:cd05612   106 YASEIVCALEYLHSKEIVYRDLKPENILLDKEGHIKLTDFGFAKKL-RDRTWTLCGTP----EYLAPEVIQSKGHNKAVD 180
                          90
                  ....*....|....*...
gi 226342982  886 VWSFGILLWEIftLGGTP 903
Cdd:cd05612   181 WWALGILIYEM--LVGYP 196
STKc_TAO1 cd06635
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze ...
798-949 6.34e-08

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO1 is sometimes referred to as prostate-derived sterile 20-like kinase 2 (PSK2). TAO1 activates the p38 MAPK through direct interaction with and activation of MEK3. TAO1 is highly expressed in the brain and may play a role in neuronal apoptosis. TAO1 interacts with the checkpoint proteins BubR1 and Mad2, and plays an important role in regulating mitotic progression, which is required for both chromosome congression and checkpoint-induced anaphase delay. TAO1 may play a role in protecting genomic stability. TAO proteins possess MAPK kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270805 [Multi-domain]  Cd Length: 317  Bit Score: 55.83  E-value: 6.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  798 LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYIskGSTFlplkWMAPESIF- 876
Cdd:cd06635   122 LQEIEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASPANSFV--GTPY----WMAPEVILa 195
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226342982  877 --NSLYTTLSDVWSFGILLWEiftLGGTPYPELPMN--DQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd06635   196 mdEGQYDGKVDVWSLGITCIE---LAERKPPLFNMNamSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRP 269
STKc_RSK2_C cd14176
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called ...
808-908 6.47e-08

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK2 is also called p90RSK3, RPS6KA3, S6K-alpha-3, or MAPK-activated protein kinase 1b (MAPKAPK-1b). RSK2 is expressed highly in the regions of the brain with high synaptic activity. It plays a role in the maintenance and consolidation of excitatory synapses. It is a specific modulator of phospholipase D in calcium-regulated exocytosis. Mutations in the RSK2 gene, RPS6KA3, cause Coffin-Lowry syndrome (CLS), a rare syndromic form of X-linked mental retardation characterized by growth and psychomotor retardation and skeletal abnormalities. RSK2 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271078 [Multi-domain]  Cd Length: 339  Bit Score: 55.80  E-value: 6.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEG----KLVKICDFGLARDiMRDSNYISKGSTFLPlKWMAPESIFNSLYTTL 883
Cdd:cd14176   120 FTITKTVEYLHAQGVVHRDLKPSNILYVDEsgnpESIRICDFGFAKQ-LRAENGLLMTPCYTA-NFVAPEVLERQGYDAA 197
                          90       100
                  ....*....|....*....|....*
gi 226342982  884 SDVWSFGILLWEIFTlGGTPYPELP 908
Cdd:cd14176   198 CDIWSLGVLLYTMLT-GYTPFANGP 221
STKc_YPK1_like cd05585
Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases; STKs catalyze the ...
806-913 7.09e-08

Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal proteins with similarity to the AGC STKs, Saccharomyces cerevisiae YPK1 and Schizosaccharomyces pombe Gad8p. YPK1 is required for cell growth and acts as a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. It also plays a role in efficient endocytosis and in the maintenance of cell wall integrity. Gad8p is a downstream target of Tor1p, the fission yeast homolog of mTOR. It plays a role in cell growth and sexual development. The YPK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270737 [Multi-domain]  Cd Length: 313  Bit Score: 55.65  E-value: 7.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNyisKGSTFLPL-KWMAPESIFNSLYTTLS 884
Cdd:cd05585    99 YTAELLCALECLHKFNVIYRDLKPENILLDYTGHIALCDFGLCKLNMKDDD---KTNTFCGTpEYLAPELLLGHGYTKAV 175
                          90       100
                  ....*....|....*....|....*....
gi 226342982  885 DVWSFGILLWEIFTlGGTPYPELPMNDQF 913
Cdd:cd05585   176 DWWTLGVLLYEMLT-GLPPFYDENTNEMY 203
PTZ00283 PTZ00283
serine/threonine protein kinase; Provisional
809-950 7.23e-08

serine/threonine protein kinase; Provisional


Pssm-ID: 240344 [Multi-domain]  Cd Length: 496  Bit Score: 56.42  E-value: 7.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrdSNYISK--GSTF--LPLkWMAPESIFNSLYTTLS 884
Cdd:PTZ00283  151 QVLLAVHHVHSKHMIHRDIKSANILLCSNGLVKLGDFGFSKMY---AATVSDdvGRTFcgTPY-YVAPEIWRRKPYSKKA 226
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226342982  885 DVWSFGILLWEIFTLggtpypelpmndqfynaiKRGYRmaqpahaSDEIYEIMQKCWEEKFETRPP 950
Cdd:PTZ00283  227 DMFSLGVLLYELLTL------------------KRPFD-------GENMEEVMHKTLAGRYDPLPP 267
STKc_MAP4K5 cd06646
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
813-913 7.53e-08

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). MAP4K5 also facilitates Wnt signaling in B cells, and may therefore be implicated in the control of cell fate, proliferation, and polarity. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270813 [Multi-domain]  Cd Length: 268  Bit Score: 55.03  E-value: 7.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  813 GMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrdSNYISKGSTFLPLK-WMAPESIF---NSLYTTLSDVWS 888
Cdd:cd06646   118 GLAYLHSKGKMHRDIKGANILLTDNGDVKLADFGVAAKI---TATIAKRKSFIGTPyWMAPEVAAvekNGGYNQLCDIWA 194
                          90       100
                  ....*....|....*....|....*
gi 226342982  889 FGILLWEIFTLGGTPYPELPMNDQF 913
Cdd:cd06646   195 VGITAIELAELQPPMFDLHPMRALF 219
STKc_GRK6 cd05630
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs ...
806-906 7.58e-08

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK6 is widely expressed in many tissues and is expressed as multiple splice variants with different domain architectures. It is post-translationally palmitoylated and localized in the membrane. GRK6 plays important roles in the regulation of dopamine, M3 muscarinic, opioid, and chemokine receptor signaling. It also plays maladaptive roles in addiction and Parkinson's disease. GRK6-deficient mice exhibit altered dopamine receptor regulation, decreased lymphocyte chemotaxis, and increased acute inflammation and neutrophil chemotaxis. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270779 [Multi-domain]  Cd Length: 285  Bit Score: 55.03  E-value: 7.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTflpLKWMAPESIFNSLYTTLSD 885
Cdd:cd05630   107 YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---VGYMAPEVVKNERYTFSPD 183
                          90       100
                  ....*....|....*....|.
gi 226342982  886 VWSFGILLWEIFTlGGTPYPE 906
Cdd:cd05630   184 WWALGCLLYEMIA-GQSPFQQ 203
STKc_p38beta cd07878
Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase ...
808-953 8.52e-08

Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase (also called MAPK11); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38beta/MAPK11 is widely expressed in tissues and shows more similarity with p38alpha than with the other isoforms. Both are sensitive to pyridinylimidazoles and share some common substrates such as MAPK activated protein kinase 2 (MK2) and the transcription factors ATF2, c-Fos and, ELK-1. p38beta is involved in regulating the activation of the cyclooxygenase-2 promoter and the expression of TGFbeta-induced alpha-smooth muscle cell actin. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143383 [Multi-domain]  Cd Length: 343  Bit Score: 55.44  E-value: 8.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyiskgSTFLPLKWM-APESIFNSL-YTTLSD 885
Cdd:cd07878   125 YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADDEM------TGYVATRWYrAPEIMLNWMhYNQTVD 198
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  886 VWSFGILLWEIFTlGGTPYPelpmNDQFYNAIKRGYRMAQPAhASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd07878   199 IWSVGCIMAELLK-GKALFP----GNDYIDQLKRIMEVVGTP-SPEVLKKISSEHARKYIQSLPHMPQ 260
STKc_RSK_C cd14091
C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases; STKs ...
605-908 9.33e-08

C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), 90 kDa ribosomal protein S6 kinases (p90-RSKs), or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270993 [Multi-domain]  Cd Length: 291  Bit Score: 54.95  E-value: 9.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  605 TLGSGAFGQVVEATahglsHSQATMKVAVKMLKSTARS-SEkqalmsELKIMSHLGPHLNVVNLLGACTKGGPIYIITEY 683
Cdd:cd14091     7 EIGKGSYSVCKRCI-----HKATGKEYAVKIIDKSKRDpSE------EIEILLRYGQHPNIITLRDVYDDGNSVYLVTEL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  684 CRYGDLVDYLHRNKHtflqrhsnkhcppsaelysnalpvgFSlpshlnltgesdggymdmskdesidyvpmldmkgdiky 763
Cdd:cd14091    76 LRGGELLDRILRQKF-------------------------FS-------------------------------------- 92
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  764 adiespsymapydnyvpsapERTYRATLindspvlsytdlvgfsYQVANGMDFLASKNCVHRDLAARNVLIC--EGK--L 839
Cdd:cd14091    93 --------------------EREASAVM----------------KTLTKTVEYLHSQGVVHRDLKPSNILYAdeSGDpeS 136
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  840 VKICDFGLARDiMRDSNyiskGSTFLPL---KWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELP 908
Cdd:cd14091   137 LRICDFGFAKQ-LRAEN----GLLMTPCytaNFVAPEVLKKQGYDAACDIWSLGVLLYTMLA-GYTPFASGP 202
PKc_MEK1 cd06650
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
807-905 9.65e-08

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. MEK1 also plays a role in cell cycle control. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270816 [Multi-domain]  Cd Length: 319  Bit Score: 55.06  E-value: 9.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  807 SYQVANGMDFLASKNCV-HRDLAARNVLICEGKLVKICDFGLARDIMRdsnyiSKGSTFLPLK-WMAPESIFNSLYTTLS 884
Cdd:cd06650   109 SIAVIKGLTYLREKHKImHRDVKPSNILVNSRGEIKLCDFGVSGQLID-----SMANSFVGTRsYMSPERLQGTHYSVQS 183
                          90       100
                  ....*....|....*....|.
gi 226342982  885 DVWSFGILLWEIfTLGGTPYP 905
Cdd:cd06650   184 DIWSMGLSLVEM-AVGRYPIP 203
STKc_EIF2AK3_PERK cd14048
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
809-896 9.66e-08

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PERK (or EIF2AK3) is a type-I ER transmembrane protein containing a luminal domain bound with the chaperone BiP under unstressed conditions and a cytoplasmic catalytic kinase domain. In response to the accumulation of misfolded or unfolded proteins in the ER, PERK is activated through the release of BiP, allowing it to dimerize and autophosphorylate. It functions as the central regulator of translational control during the Unfolded Protein Response (UPR) pathway. In addition to the eIF-2 alpha subunit, PERK also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PERK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270950 [Multi-domain]  Cd Length: 281  Bit Score: 54.88  E-value: 9.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGsTFLPLK-----------WMAPESIFN 877
Cdd:cd14048   126 QIASAVEYLHSKGLIHRDLKPSNVFFSLDDVVKVGDFGLVTAMDQGEPEQTVL-TPMPAYakhtgqvgtrlYMSPEQIHG 204
                          90
                  ....*....|....*....
gi 226342982  878 SLYTTLSDVWSFGILLWEI 896
Cdd:cd14048   205 NQYSEKVDIFALGLILFEL 223
STKc_Nek6_7 cd08224
Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related ...
808-899 1.06e-07

Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 and Nek7 are the shortest Neks, consisting only of the catalytic domain and a very short N-terminal extension. They show distinct expression patterns and both appear to be downstream substrates of Nek9. They are required for mitotic spindle formation and cytokinesis. They may also be regulators of the p70 ribosomal S6 kinase. Nek6/7 is part of a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270863 [Multi-domain]  Cd Length: 262  Bit Score: 54.58  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdimrdsnYISKGSTF------LPLkWMAPESIFNSLYT 881
Cdd:cd08224   111 VQLCSALEHMHSKRIMHRDIKPANVFITANGVVKLGDLGLGR-------FFSSKTTAahslvgTPY-YMSPERIREQGYD 182
                          90
                  ....*....|....*...
gi 226342982  882 TLSDVWSFGILLWEIFTL 899
Cdd:cd08224   183 FKSDIWSLGCLLYEMAAL 200
STKc_GRK cd05577
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs ...
794-904 1.07e-07

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. GRKs play important roles in the cardiovascular, immune, respiratory, skeletal, and nervous systems. They contain a central catalytic domain, flanked by N- and C-terminal extensions. The N-terminus contains an RGS (regulator of G protein signaling) homology (RH) domain and several motifs. The C-terminus diverges among different groups of GRKs. There are seven types of GRKs, named GRK1 to GRK7, which are subdivided into three main groups: visual (GRK1/7); beta-adrenergic receptor kinases (GRK2/3); and GRK4-like (GRK4/5/6). Expression of GRK2/3/5/6 is widespread while GRK1/4/7 show a limited tissue distribution. The substrate spectrum of the widely expressed GRKs partially overlaps. The GRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270729 [Multi-domain]  Cd Length: 278  Bit Score: 54.46  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  794 DSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNyiSKGSTFLPlKWMAPE 873
Cdd:cd05577    88 GTRGFSEARAIFYAAEIICGLEHLHNRFIVYRDLKPENILLDDHGHVRISDLGLAVEFKGGKK--IKGRVGTH-GYMAPE 164
                          90       100       110
                  ....*....|....*....|....*....|..
gi 226342982  874 SIFNSL-YTTLSDVWSFGILLWEIFTlGGTPY 904
Cdd:cd05577   165 VLQKEVaYDFSVDWFALGCMLYEMIA-GRSPF 195
STKc_MLCK cd14103
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the ...
792-891 1.17e-07

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module. MLCK2, MLCK3, and MLCK4 share a simpler domain architecture of a single kinase domain near the C-terminus and the absence of Ig-like or FN3 domains. The MLCK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271005 [Multi-domain]  Cd Length: 250  Bit Score: 54.15  E-value: 1.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  792 INDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLiC---EGKLVKICDFGLARdimrdsNYISKGST---FL 865
Cdd:cd14103    82 VDDDFELTERDCILFMRQICEGVQYMHKQGILHLDLKPENIL-CvsrTGNQIKIIDFGLAR------KYDPDKKLkvlFG 154
                          90       100
                  ....*....|....*....|....*.
gi 226342982  866 PLKWMAPESIFNSLYTTLSDVWSFGI 891
Cdd:cd14103   155 TPEFVAPEVVNYEPISYATDMWSVGV 180
STKc_cPKC cd05587
Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; ...
804-903 1.26e-07

Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. cPKCs are potent kinases for histones, myelin basic protein, and protamine. They depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. cPKCs contain a calcium-binding C2 region in their regulatory domain. There are four cPKC isoforms, named alpha, betaI, betaII, and gamma. PKC-gamma is mainly expressed in neuronal tissues. It plays a role in protection from ischemia. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The cPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270739 [Multi-domain]  Cd Length: 320  Bit Score: 54.71  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  804 VGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyiSKGSTF--LPlKWMAPESIFNSLYT 881
Cdd:cd05587   100 VFYAAEIAVGLFFLHSKGIIYRDLKLDNVMLDAEGHIKIADFGMCKEGIFGG---KTTRTFcgTP-DYIAPEIIAYQPYG 175
                          90       100
                  ....*....|....*....|..
gi 226342982  882 TLSDVWSFGILLWEIftLGGTP 903
Cdd:cd05587   176 KSVDWWAYGVLLYEM--LAGQP 195
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
218-303 1.27e-07

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 50.09  E-value: 1.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   218 NAVQTVVRQGESITIRCIVMGNDVVNFQWTyprmKSGRLVEPvtdylfgvpsriGSILHIPTAELSDSGTYTCNVSvsvN 297
Cdd:pfam13895    5 TPSPTVVTEGEPVTLTCSAPGNPPPSYTWY----KDGSAISS------------SPNFFTLSVSAEDSGTYTCVAR---N 65

                   ....*.
gi 226342982   298 DHGDEK 303
Cdd:pfam13895   66 GRGGKV 71
STKc_MOK cd07831
Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs ...
806-939 1.28e-07

Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MOK, also called Renal tumor antigen 1 (RAGE-1), is widely expressed and is enriched in testis, kidney, lung, and brain. It is expressed in approximately 50% of renal cell carcinomas (RCC) and is a potential target for immunotherapy. MOK is stabilized by its association with the HSP90 molecular chaperone. It is induced by the transcription factor Cdx2 and may be involved in regulating intestinal epithelial development and differentiation. The MOK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270825 [Multi-domain]  Cd Length: 282  Bit Score: 54.59  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLIcEGKLVKICDFGLARDIMRD---SNYISKgstflplKWM-APESIFNS-LY 880
Cdd:cd07831   105 YMYQLLKSLDHMHRNGIFHRDIKPENILI-KDDILKLADFGSCRGIYSKppyTEYIST-------RWYrAPECLLTDgYY 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  881 TTLSDVWSFGILLWEIFTLG-------------------GTPYPELP--------MNDQFYNAIKRGYRMAQPaHASDEI 933
Cdd:cd07831   177 GPKMDIWAVGCVFFEILSLFplfpgtneldqiakihdvlGTPDAEVLkkfrksrhMNYNFPSKKGTGLRKLLP-NASAEG 255

                  ....*.
gi 226342982  934 YEIMQK 939
Cdd:cd07831   256 LDLLKK 261
PK_ILK cd14057
Pseudokinase domain of Integrin Linked Kinase; The pseudokinase domain shows similarity to ...
797-953 1.38e-07

Pseudokinase domain of Integrin Linked Kinase; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. ILK contains N-terminal ankyrin repeats, a Pleckstrin Homology (PH) domain, and a C-terminal pseudokinase domain. It is a component of the IPP (ILK/PINCH/Parvin) complex that couples beta integrins to the actin cytoskeleton, and plays important roles in cell adhesion, spreading, invasion, and migration. ILK was initially thought to be an active kinase despite the lack of key conserved residues because of in vitro studies showing that it can phosphorylate certain protein substrates. However, in vivo experiments in Caenorhabditis elegans, Drosophila melanogaster, and mice (ILK-null and knock-in) proved that ILK is not an active kinase. In addition to actin cytoskeleton regulation, ILK also influences the microtubule network and mitotic spindle orientation. The pseudokinase domain of ILK binds several adaptor proteins including the parvins and paxillin. The ILK subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270959 [Multi-domain]  Cd Length: 251  Bit Score: 54.03  E-value: 1.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  797 VLSYTDLVGFSYQVANGMDFLASKNCV--HRDLAARNVLICEGKLVKICdfglardiMRDS--NYISKGSTFLPlKWMAP 872
Cdd:cd14057    90 VVDQSQAVKFALDIARGMAFLHTLEPLipRHHLNSKHVMIDEDMTARIN--------MADVkfSFQEPGKMYNP-AWMAP 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  873 ESIFNS---LYTTLSDVWSFGILLWEIFTLgGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd14057   161 EALQKKpedINRRSADMWSFAILLWELVTR-EVPFADLSNMEIGMKIALEGLRVTIPPGISPHMCKLMKICMNEDPGKRP 239

                  ....
gi 226342982  950 PFSQ 953
Cdd:cd14057   240 KFDM 243
STKc_MEKK3_like_u1 cd06653
Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP) ...
806-950 1.40e-07

Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of uncharacterized proteins with similarity to MEKK3, MEKK2, and related proteins; they contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKKs), proteins that phosphorylate and activate MAPK kinases (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MEKK2 and MEKK3 activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270819 [Multi-domain]  Cd Length: 264  Bit Score: 54.26  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrDSNYIS----KGSTFLPLkWMAPESIFNSLYT 881
Cdd:cd06653   111 YTRQILQGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRI--QTICMSgtgiKSVTGTPY-WMSPEVISGEGYG 187
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226342982  882 TLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEkfETRPP 950
Cdd:cd06653   188 RKADVWSVACTVVEMLT-EKPPWAEYEAMAAIFKIATQPTKPQLPDGVSDACRDFLRQIFVE--EKRRP 253
STKc_CASK cd14094
Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein ...
800-920 1.67e-07

Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CASK belongs to the MAGUK (membrane-associated guanylate kinase) protein family, which functions as multiple domain adaptor proteins and is characterized by the presence of a core of three domains: PDZ, SH3, and guanylate kinase (GuK). The enzymatically inactive GuK domain in MAGUK proteins mediates protein-protein interactions and associates intramolecularly with the SH3 domain. In addition, CASK contains a catalytic kinase and two L27 domains. It is highly expressed in the nervous system and plays roles in synaptic protein targeting, neural development, and regulation of gene expression. Binding partners include parkin (a Parkinson's disease molecule), neurexin (adhesion molecule), syndecans, calcium channel proteins, CINAP (nucleosome assembly protein), transcription factor Tbr-1, and the cytoplasmic adaptor proteins Mint1, Veli/mLIN-7/MALS, SAP97, caskin, and CIP98. Deletion or mutations in the CASK gene have been implicated in X-linked mental retardation. The CASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270996 [Multi-domain]  Cd Length: 300  Bit Score: 54.08  E-value: 1.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  800 YTDLVGFSY--QVANGMDFLASKNCVHRDLAARNVLICE---GKLVKICDFGLARDiMRDSNYISKGSTFLPlKWMAPES 874
Cdd:cd14094   106 YSEAVASHYmrQILEALRYCHDNNIIHRDVKPHCVLLASkenSAPVKLGGFGVAIQ-LGESGLVAGGRVGTP-HFMAPEV 183
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 226342982  875 IFNSLYTTLSDVWSFGILLWeiFTLGGTPyPELPMNDQFYNAIKRG 920
Cdd:cd14094   184 VKREPYGKPVDVWGCGVILF--ILLSGCL-PFYGTKERLFEGIIKG 226
STKc_PDIK1L cd13977
Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like; STKs ...
806-894 1.67e-07

Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDIK1L is also called STK35 or CLIK-1. It is predominantly a nuclear protein which is capable of autophosphorylation. Through its interaction with the PDZ-LIM protein CLP-36, it is localized to actin stress fibers. The PDIK1L subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270879 [Multi-domain]  Cd Length: 322  Bit Score: 54.48  E-value: 1.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGK---LVKICDFGLARdIMRDSNYISK--------------GSTFlplk 868
Cdd:cd13977   139 FMLQLSSALAFLHRNQIVHRDLKPDNILISHKRgepILKVADFGLSK-VCSGSGLNPEepanvnkhflssacGSDF---- 213
                          90       100
                  ....*....|....*....|....*.
gi 226342982  869 WMAPEsIFNSLYTTLSDVWSFGILLW 894
Cdd:cd13977   214 YMAPE-VWEGHYTAKADIFALGIIIW 238
STKc_ACVR2 cd14053
Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the ...
797-948 1.69e-07

Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as ACVR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. Vertebrates contain two ACVR2 proteins, ACVR2a (or ActRIIA) and ACVR2b (or ActRIIB). The ACVR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270955 [Multi-domain]  Cd Length: 290  Bit Score: 54.26  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  797 VLSYTDLVGFSYQVANGMDFL---------ASKNCV-HRDLAARNVLICEGKLVKICDFGLArdiMRDSNYISKGSTFLP 866
Cdd:cd14053    88 VISWNELCKIAESMARGLAYLhedipatngGHKPSIaHRDFKSKNVLLKSDLTACIADFGLA---LKFEPGKSCGDTHGQ 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  867 L---KWMAPESI-----FNSLYTTLSDVWSFGILLWEI---FTLGGTPYPE--LP----------MND-QFYNAIKRGYR 922
Cdd:cd14053   165 VgtrRYMAPEVLegainFTRDAFLRIDMYAMGLVLWELlsrCSVHDGPVDEyqLPfeeevgqhptLEDmQECVVHKKLRP 244
                         170       180       190
                  ....*....|....*....|....*....|
gi 226342982  923 MAQPAHASDE----IYEIMQKCWEEKFETR 948
Cdd:cd14053   245 QIRDEWRKHPglaqLCETIEECWDHDAEAR 274
STKc_MSK2_C cd14180
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
816-945 1.78e-07

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271082 [Multi-domain]  Cd Length: 309  Bit Score: 54.11  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  816 FLASKNCVHRDLAARNVLIC---EGKLVKICDFGLARdiMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGIL 892
Cdd:cd14180   116 FMHEAGVVHRDLKPENILYAdesDGAVLKVIDFGFAR--LRPQGSRPLQTPCFTLQYAAPELFSNQGYDESCDLWSLGVI 193
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 226342982  893 LWEIFTlGGTPypelpmndqfynaikrgYRMAQPAHASDEIYEIMQKCWEEKF 945
Cdd:cd14180   194 LYTMLS-GQVP-----------------FQSKRGKMFHNHAADIMHKIKEGDF 228
STKc_KSR1 cd14152
Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1; STKs catalyze the ...
809-953 1.82e-07

Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. KSR1 functions as a transducer of TNFalpha-stimulated C-Raf activation of ERK1/2 and NF-kB. Detected activity of KSR1 is cell type specific and context dependent. It is inactive in normal colon epithelial cells and becomes activated at the onset of inflammatory bowel disease (IBD). Similarly, KSR1 activity is undetectable prior to stimulation by EGF or ceramide in COS-7 or YAMC cells, respectively. KSR proteins are widely regarded as pseudokinases, however, this matter is up for debate as catalytic activity has been detected for KSR1 in some systems. The KSR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271054 [Multi-domain]  Cd Length: 279  Bit Score: 53.82  E-value: 1.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVkICDFGL--ARDIMRDSNyiSKGSTFLPLKW---MAPEsIFNSL---- 879
Cdd:cd14152   105 EIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVV-ITDFGLfgISGVVQEGR--RENELKLPHDWlcyLAPE-IVREMtpgk 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  880 ------YTTLSDVWSFGILLWEIftlggtPYPELPMNDQFYNA----IKRGYRMAQ---PAHASDEIYEIMQKCWEEKFE 946
Cdd:cd14152   181 dedclpFSKAADVYAFGTIWYEL------QARDWPLKNQPAEAliwqIGSGEGMKQvltTISLGKEVTEILSACWAFDLE 254

                  ....*..
gi 226342982  947 TRPPFSQ 953
Cdd:cd14152   255 ERPSFTL 261
PKc_DYRK_like cd14133
Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like ...
806-898 1.85e-07

Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like protein kinases; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity DYRKs and YAK1, as well as the S/T kinases (STKs), HIPKs. DYRKs and YAK1 autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. Proteins in this subfamily play important roles in cell proliferation, differentiation, survival, growth, and development. The DYRK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271035 [Multi-domain]  Cd Length: 262  Bit Score: 53.81  E-value: 1.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICE--GKLVKICDFGLARDI-MRDSNYISkgSTFlplkWMAPESIFNSLYTT 882
Cdd:cd14133   107 IAQQILEALVFLHSLGLIHCDLKPENILLASysRCQIKIIDFGSSCFLtQRLYSYIQ--SRY----YRAPEVILGLPYDE 180
                          90
                  ....*....|....*.
gi 226342982  883 LSDVWSFGILLWEIFT 898
Cdd:cd14133   181 KIDMWSLGCILAELYT 196
STKc_DCKL2 cd14184
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called ...
792-933 1.88e-07

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL2 (or DCAMKL2) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL2 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL2 has been shown to interact with tubulin, JIP1/2, JNK, neurabin 2, and actin. It is associated with the terminal segments of axons and dendrites, and may function as a phosphorylation-dependent switch to control microtubule dynamics in neuronal growth cones. The DCKL2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271086 [Multi-domain]  Cd Length: 259  Bit Score: 53.50  E-value: 1.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  792 INDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICE----GKLVKICDFGLArDIMRDSNYISKGSTflpl 867
Cdd:cd14184    90 ITSSTKYTERDASAMVYNLASALKYLHGLCIVHRDIKPENLLVCEypdgTKSLKLGDFGLA-TVVEGPLYTVCGTP---- 164
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226342982  868 KWMAPESIFNSLYTTLSDVWSFGILLWeIFTLGGTPY-PELPMNDQFYNAIKRGyRMAQPAHASDEI 933
Cdd:cd14184   165 TYVAPEIIAETGYGLKVDIWAAGVITY-ILLCGFPPFrSENNLQEDLFDQILLG-KLEFPSPYWDNI 229
STKc_CaMKII cd14086
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
808-920 2.05e-07

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain followed by a regulatory domain that harbors a CaM binding site. In addition, CaMKII contains a C-terminal association domain that facilitates oligomerization. There are four CaMKII proteins (alpha, beta, gamma, delta) encoded by different genes; each gene undergoes alternative splicing to produce more than 30 isoforms. CaMKII-alpha and -beta are enriched in neurons while CaMKII-gamma and -delta are predominant in myocardium. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. It is a major component of the postsynaptic density and is critical in regulating synaptic plasticity including long-term potentiation. It is critical in regulating ion channels and proteins involved in myocardial excitation-contraction and excitation-transcription coupling. Excessive CaMKII activity promotes processes that contribute to heart failure and arrhythmias. The CaMKII subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270988 [Multi-domain]  Cd Length: 292  Bit Score: 53.97  E-value: 2.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLI---CEGKLVKICDFGLARDIMRDSN-YISKGSTFlplKWMAPESIFNSLYTTL 883
Cdd:cd14086   107 QQILESVNHCHQNGIVHRDLKPENLLLaskSKGAAVKLADFGLAIEVQGDQQaWFGFAGTP---GYLSPEVLRKDPYGKP 183
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 226342982  884 SDVWSFGILLWeIFTLGgtpYPELPMNDQ--FYNAIKRG 920
Cdd:cd14086   184 VDIWACGVILY-ILLVG---YPPFWDEDQhrLYAQIKAG 218
STKc_nPKC_eta cd05590
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta; STKs catalyze the ...
806-950 2.13e-07

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-eta is predominantly expressed in squamous epithelia, where it plays a crucial role in the signaling of cell-type specific differentiation. It is also expressed in pro-B cells and early-stage thymocytes, and acts as a key regulator in early B-cell development. PKC-eta increases glioblastoma multiforme (GBM) proliferation and resistance to radiation, and is being developed as a therapeutic target for the management of GBM. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-eta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270742 [Multi-domain]  Cd Length: 323  Bit Score: 54.14  E-value: 2.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyiSKGSTFLPL-KWMAPESIFNSLYTTLS 884
Cdd:cd05590   101 YAAEITSALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGIFNG---KTTSTFCGTpDYIAPEILQEMLYGPSV 177
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226342982  885 DVWSFGILLWEIFTlGGTPYpELPMNDQFYNAIKRGyRMAQPAHASDEIYEIMQkcweeKFETRPP 950
Cdd:cd05590   178 DWWAMGVLLYEMLC-GHAPF-EAENEDDLFEAILND-EVVYPTWLSQDAVDILK-----AFMTKNP 235
STKc_PCTAIRE1 cd07873
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer ...
806-915 2.16e-07

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-1 is expressed ubiquitously and is localized in the cytoplasm. Its kinase activity is cell cycle dependent and peaks at the S and G2 phases. PCTAIRE-1 is highly expressed in the brain and may play a role in regulating neurite outgrowth. It can also associate with Trap (Tudor repeat associator with PCTAIRE-2), a physiological partner of PCTAIRE-2; with p11, a small dimeric protein with similarity to S100; and with 14-3-3 proteins, mediators of phosphorylation-dependent interactions in many different proteins. PCTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270854 [Multi-domain]  Cd Length: 297  Bit Score: 53.85  E-value: 2.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLAR-DIMRDSNYISKGSTFlplkWMAPESIF--NSLYTT 882
Cdd:cd07873   105 FLFQLLRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARaKSIPTKTYSNEVVTL----WYRPPDILlgSTDYST 180
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  883 LSDVWSFGILLWE-------------------IFTLGGTP----YPELPMNDQF--YN 915
Cdd:cd07873   181 QIDMWGVGCIFYEmstgrplfpgstveeqlhfIFRILGTPteetWPGILSNEEFksYN 238
PTZ00263 PTZ00263
protein kinase A catalytic subunit; Provisional
806-909 2.39e-07

protein kinase A catalytic subunit; Provisional


Pssm-ID: 140289 [Multi-domain]  Cd Length: 329  Bit Score: 54.05  E-value: 2.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImRDSNYISKGSTflplKWMAPESIFNSLYTTLSD 885
Cdd:PTZ00263  123 YHAELVLAFEYLHSKDIIYRDLKPENLLLDNKGHVKVTDFGFAKKV-PDRTFTLCGTP----EYLAPEVIQSKGHGKAVD 197
                          90       100
                  ....*....|....*....|....*
gi 226342982  886 VWSFGILLWEiFTLGGTP-YPELPM 909
Cdd:PTZ00263  198 WWTMGVLLYE-FIAGYPPfFDDTPF 221
PKc_like cd13968
Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large ...
802-846 2.62e-07

Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large family of typical PKs that includes serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins, as well as pseudokinases that lack crucial residues for catalytic activity and/or ATP binding. It also includes phosphoinositide 3-kinases (PI3Ks), aminoglycoside 3'-phosphotransferases (APHs), choline kinase (ChoK), Actin-Fragmin Kinase (AFK), and the atypical RIO and Abc1p-like protein kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to their target substrates; these include serine/threonine/tyrosine residues in proteins for typical or atypical PKs, the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives for PI3Ks, the 4-hydroxyl of PtdIns for PI4Ks, and other small molecule substrates for APH/ChoK and similar proteins such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine.


Pssm-ID: 270870 [Multi-domain]  Cd Length: 136  Bit Score: 50.90  E-value: 2.62e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 226342982  802 DLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFG 846
Cdd:cd13968    92 DVESIMYQLAECMRLLHSFHLIHRDLNNDNILLSEDGNVKLIDFG 136
STKc_Nek8 cd08220
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
798-953 2.63e-07

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek8 contains an N-terminal kinase catalytic domain and a C-terminal RCC1 (regulator of chromosome condensation) domain. A double point mutation in Nek8 causes cystic kidney disease in mice that genetically resembles human autosomal recessive polycystic kidney disease (ARPKD). Nek8 is also associated with a rare form of juvenile renal cystic disease, nephronophthisis type 9. It has been suggested that a defect in the ciliary localization of Nek8 contributes to the development of cysts manifested by these diseases. Nek8 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270859 [Multi-domain]  Cd Length: 256  Bit Score: 53.20  E-value: 2.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  798 LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGK-LVKICDFGLARDImrdsNYISKGSTFLPLK-WMAPESI 875
Cdd:cd08220    98 LSEEEILHFFVQILLALHHVHSKQILHRDLKTQNILLNKKRtVVKIGDFGISKIL----SSKSKAYTVVGTPcYISPELC 173
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  876 FNSLYTTLSDVWSFGILLWEIFTLG----GTPYPELPMNdqfynaIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPF 951
Cdd:cd08220   174 EGKPYNQKSDIWALGCVLYELASLKrafeAANLPALVLK------IMRGTFAPISDRYSEELRHLILSMLHLDPNKRPTL 247

                  ..
gi 226342982  952 SQ 953
Cdd:cd08220   248 SE 249
STKc_Nek1 cd08218
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
809-949 2.63e-07

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek1 is associated with centrosomes throughout the cell cycle. It is involved in the formation of primary cilium and in the maintenance of centrosomes. It cycles through the nucleus and may be capable of relaying signals between the cilium and the nucleus. Nek1 is implicated in the development of polycystic kidney disease, which is characterized by benign polycystic tumors formed by abnormal overgrowth of renal epithelial cells. It appears also to be involved in DNA damage response, and may be important for both correct DNA damage checkpoint activation and DNA repair. Nek1 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270858 [Multi-domain]  Cd Length: 256  Bit Score: 53.28  E-value: 2.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdIMRDSNYISKGSTFLPLkWMAPESIFNSLYTTLSDVWS 888
Cdd:cd08218   109 QLCLALKHVHDRKILHRDIKSQNIFLTKDGIIKLGDFGIAR-VLNSTVELARTCIGTPY-YLSPEICENKPYNNKSDIWA 186
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226342982  889 FGILLWEIFTLgGTPYPELPMNDQFYNAIkRGYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd08218   187 LGCVLYEMCTL-KHAFEAGNMKNLVLKII-RGSYPPVPSRYSYDLRSLVSQLFKRNPRDRP 245
STKc_MAP3K8 cd13995
Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) ...
802-905 2.88e-07

Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K8 is also called Tumor progression locus 2 (Tpl2) or Cancer Osaka thyroid (Cot), and was first identified as a proto-oncogene in T-cell lymphoma induced by MoMuL virus and in breast carcinoma induced by MMTV. Activated MAP3K8 induces various MAPK pathways including Extracellular Regulated Kinase (ERK) 1/2, c-Jun N-terminal kinase (JNK), and p38. It plays a pivotal role in innate immunity, linking Toll-like receptors to the production of TNF and the activation of ERK in macrophages. It is also required in interleukin-1beta production and is critical in host defense against Gram-positive bacteria. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K8 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270897 [Multi-domain]  Cd Length: 256  Bit Score: 53.09  E-value: 2.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  802 DLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVkICDFGLARDiMRDSNYISK---GSTFlplkWMAPESIFNS 878
Cdd:cd13995    97 EIIWVTKHVLKGLDFLHSKNIIHHDIKPSNIVFMSTKAV-LVDFGLSVQ-MTEDVYVPKdlrGTEI----YMSPEVILCR 170
                          90       100       110
                  ....*....|....*....|....*....|..
gi 226342982  879 LYTTLSDVWSFGILLweIFTLGGTP-----YP 905
Cdd:cd13995   171 GHNTKADIYSLGATI--IHMQTGSPpwvrrYP 200
STKc_GRK4_like cd05605
Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs ...
809-904 2.95e-07

Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the GRK4-like group include GRK4, GRK5, GRK6, and similar GRKs. They contain an N-terminal RGS homology (RH) domain and a catalytic domain, but lack a G protein betagamma-subunit binding domain. They are localized to the plasma membrane through post-translational lipid modification or direct binding to PIP2. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270756 [Multi-domain]  Cd Length: 285  Bit Score: 53.51  E-value: 2.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImRDSNYIsKGSTFLPlKWMAPESIFNSLYTTLSDVWS 888
Cdd:cd05605   110 EITCGLEHLHSERIVYRDLKPENILLDDHGHVRISDLGLAVEI-PEGETI-RGRVGTV-GYMAPEVVKNERYTFSPDWWG 186
                          90
                  ....*....|....*.
gi 226342982  889 FGILLWEIFTlGGTPY 904
Cdd:cd05605   187 LGCLIYEMIE-GQAPF 201
STKc_BUR1 cd07866
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), ...
791-898 3.03e-07

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), Bypass UAS Requirement 1, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BUR1, also called SGV1, is a yeast CDK that is functionally equivalent to mammalian CDK9. It associates with the cyclin BUR2. BUR genes were orginally identified in a genetic screen as factors involved in general transcription. The BUR1/BUR2 complex phosphorylates the C-terminal domain of RNA polymerase II. In addition, this complex regulates histone modification by phosporylating Rad6 and mediating the association of the Paf1 complex with chromatin. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The BUR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270849 [Multi-domain]  Cd Length: 311  Bit Score: 53.47  E-value: 3.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  791 LINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDS---NYISKGST--FL 865
Cdd:cd07866   105 LENPSVKLTESQIKCYMLQLLEGINYLHENHILHRDIKAANILIDNQGILKIADFGLARPYDGPPpnpKGGGGGGTrkYT 184
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 226342982  866 PL---KWM-APESIFNSL-YTTLSDVWSFGILLWEIFT 898
Cdd:cd07866   185 NLvvtRWYrPPELLLGERrYTTAVDIWGIGCVFAEMFT 222
STKc_CDK1_euk cd07861
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher ...
806-898 3.23e-07

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression. CDK1/cyclin A2 has also been implicated as an important regulator of S phase events. The CDK1/cyclin B complex is critical for G2 to M phase transition. It induces mitosis by activating nuclear enzymes that regulate chromatin condensation, nuclear membrane degradation, mitosis-specific microtubule and cytoskeletal reorganization. CDK1 also associates with cyclin E and plays a role in the entry into S phase. CDK1 transcription is stable throughout the cell cycle but is modulated in some pathological conditions. It may play a role in regulating apoptosis under these conditions. In breast cancer cells, HER2 can mediate apoptosis by inactivating CDK1. Activation of CDK1 may contribute to HIV-1 induced apoptosis as well as neuronal apoptosis in neurodegenerative diseases. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270845 [Multi-domain]  Cd Length: 285  Bit Score: 53.19  E-value: 3.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI---MRdsNYISKGSTflpLKWMAPESIFNS-LYT 881
Cdd:cd07861   106 YLYQILQGILFCHSRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFgipVR--VYTHEVVT---LWYRAPEVLLGSpRYS 180
                          90
                  ....*....|....*..
gi 226342982  882 TLSDVWSFGILLWEIFT 898
Cdd:cd07861   181 TPVDIWSIGTIFAEMAT 197
STKc_LRRK1 cd14067
Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1; STKs catalyze ...
807-949 3.57e-07

Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRK1 is one of two vertebrate LRRKs which show complementary expression in the brain. It can form heterodimers with LRRK2, and may influence the age of onset of LRRK2-associated Parkinson's disease. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. The LRRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270969 [Multi-domain]  Cd Length: 276  Bit Score: 53.04  E-value: 3.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  807 SYQVANGMDFLASKNCVHRDLAARNVLIC-----EGKLVKICDFGLARDIMRDSNYISKGSTflplKWMAPESIFNSLYT 881
Cdd:cd14067   120 AYQIAAGLAYLHKKNIIFCDLKSDNILVWsldvqEHINIKLSDYGISRQSFHEGALGVEGTP----GYQAPEIRPRIVYD 195
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226342982  882 TLSDVWSFGILLWEIFTlGGTP---YPELpmndQFYNAIKRGYR--MAQPAHAS-DEIYEIMQKCWEEKFETRP 949
Cdd:cd14067   196 EKVDMFSYGMVLYELLS-GQRPslgHHQL----QIAKKLSKGIRpvLGQPEEVQfFRLQALMMECWDTKPEKRP 264
STKc_IKK_beta cd14038
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
810-908 3.63e-07

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKbeta is involved in the classical pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The classical pathway regulates the majority of genes activated by NF-kB including those encoding cytokines, chemokines, leukocyte adhesion molecules, and anti-apoptotic factors. It involves NEMO (NF-kB Essential MOdulator)- and IKKbeta-dependent phosphorylation and degradation of the Inhibitor of NF-kB (IkB), which liberates NF-kB dimers (typified by the p50-p65 heterodimer) from an inactive IkB/dimeric NF-kB complex, enabling them to migrate to the nucleus where they regulate gene transcription. The IKKbeta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270940 [Multi-domain]  Cd Length: 290  Bit Score: 53.04  E-value: 3.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLICEG--KLV-KICDFGLARDIMRDSNYISKGSTflpLKWMAPESIFNSLYTTLSDV 886
Cdd:cd14038   110 ISSALRYLHENRIIHRDLKPENIVLQQGeqRLIhKIIDLGYAKELDQGSLCTSFVGT---LQYLAPELLEQQKYTVTVDY 186
                          90       100
                  ....*....|....*....|..
gi 226342982  887 WSFGILLWEIFTlGGTPYpeLP 908
Cdd:cd14038   187 WSFGTLAFECIT-GFRPF--LP 205
STKc_BMPR1a cd14220
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor; ...
824-948 3.65e-07

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1a, also called Activin receptor-Like Kinase 3 (ALK3), functions as a receptor for bone morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Germline mutations in BMPR1a are associated with an increased risk to Juvenile Polyposis Syndrome, a hamartomatous disorder that may lead to gastrointestinal cancer. BMPR1a may also play an indirect role in the development of hematopoietic stem cells (HSCs) as osteoblasts are a major component of the HSC niche within the bone marrow. BMPR1a belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1a, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1a subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271122 [Multi-domain]  Cd Length: 287  Bit Score: 53.12  E-value: 3.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  824 HRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISkgstfLPL-------KWMAPESIFNSLYTT------LSDVWSFG 890
Cdd:cd14220   123 HRDLKSKNILIKKNGTCCIADLGLAVKFNSDTNEVD-----VPLntrvgtkRYMAPEVLDESLNKNhfqayiMADIYSFG 197
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226342982  891 ILLWEIF---TLGGT------PYPELPMNDQFYN------AIKRGYRMAQPAHASDE----IYEIMQKCWEEKFETR 948
Cdd:cd14220   198 LIIWEMArrcVTGGIveeyqlPYYDMVPSDPSYEdmrevvCVKRLRPTVSNRWNSDEclraVLKLMSECWAHNPASR 274
STKc_MELK cd14078
Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; ...
605-920 3.73e-07

Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MELK is a cell cycle dependent protein which functions in cytokinesis, cell cycle, apoptosis, cell proliferation, and mRNA processing. It is found upregulated in many types of cancer cells, playing an indispensable role in cancer cell survival. It makes an attractive target in the design of inhibitors for use in the treatment of a wide range of human cancer. The MELK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270980 [Multi-domain]  Cd Length: 257  Bit Score: 52.77  E-value: 3.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  605 TLGSGAFGQVVEATahglsHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITEYC 684
Cdd:cd14078    10 TIGSGGFAKVKLAT-----HILTGEKVAIKIMDKKALGDDLPRVKTEIEALKNLS-HQHICRLYHVIETDNKIFMVLEYC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  685 RYGDLVDYLhrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdMSKDEsidyvpmldmkgdikya 764
Cdd:cd14078    84 PGGELFDYI-------------------------------------------------VAKDR----------------- 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  765 diespsymapydnyvpsapertyratlindspvLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICD 844
Cdd:cd14078    98 ---------------------------------LSEDEARVFFRQIVSAVAYVHSQGYAHRDLKPENLLLDEDQNLKLID 144
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  845 FGLA---RDIMRDSNYISKGStflpLKWMAPESIFNSLYT-TLSDVWSFGILLWEIftLGGTpypeLPMNDQ----FYNA 916
Cdd:cd14078   145 FGLCakpKGGMDHHLETCCGS----PAYAAPELIQGKPYIgSEADVWSMGVLLYAL--LCGF----LPFDDDnvmaLYRK 214

                  ....
gi 226342982  917 IKRG 920
Cdd:cd14078   215 IQSG 218
PKc_YAK1 cd14212
Catalytic domain of the Dual-specificity protein kinase, YAK1; Dual-specificity PKs catalyze ...
798-919 3.75e-07

Catalytic domain of the Dual-specificity protein kinase, YAK1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of proteins with similarity to Saccharomyces cerevisiae YAK1 (or Yak1p), a dual-specificity kinase that autophosphorylates at tyrosine residues and phosphorylates substrates on S/T residues. YAK1 phosphorylates and activates the transcription factors Hsf1 and Msn2, which play important roles in cellular homeostasis during stress conditions including heat shock, oxidative stress, and nutrient deficiency. It also phosphorylates the protein POP2, a component of a complex that regulates transcription, under glucose-deprived conditions. It functions as a part of a glucose-sensing system that is involved in controlling growth in yeast. The YAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271114 [Multi-domain]  Cd Length: 330  Bit Score: 53.41  E-value: 3.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  798 LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICE--GKLVKICDFGLArdIMRDS---NYISkgSTFlplkWMAP 872
Cdd:cd14212   100 LSLQLIRKFLQQLLDALSVLKDARIIHCDLKPENILLVNldSPEIKLIDFGSA--CFENYtlyTYIQ--SRF----YRSP 171
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 226342982  873 ESIFNSLYTTLSDVWSFGILLWEIFtLGgtpYPELPMNDQfYNAIKR 919
Cdd:cd14212   172 EVLLGLPYSTAIDMWSLGCIAAELF-LG---LPLFPGNSE-YNQLSR 213
STKc_LKB1 cd14119
Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer ...
809-953 3.85e-07

Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LKB1, also called STK11, was first identified as a tumor suppressor responsible for Peutz-Jeghers syndrome, a disorder that leads to an increased risk of spontaneous epithelial cancer. It serves as a master upstream kinase that activates AMP-activated protein kinase (AMPK) and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. To be activated, LKB1 requires the adaptor proteins STe20-Related ADaptor (STRAD) and mouse protein 25 (MO25). The LKB1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271021 [Multi-domain]  Cd Length: 255  Bit Score: 52.64  E-value: 3.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMR----DSNYISKGStflPlKWMAPEsIFNSLYTTLS 884
Cdd:cd14119   105 QLIDGLEYLHSQGIIHKDIKPGNLLLTTDGTLKISDFGVAEALDLfaedDTCTTSQGS---P-AFQPPE-IANGQDSFSG 179
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  885 ---DVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRMaqPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14119   180 fkvDIWSAGVTLYNMTT-GKYPFEGDNIYKLFENIGKGEYTI--PDDVDPDLQDLLRGMLEKDPEKRFTIEQ 248
STKc_STK33 cd14097
Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the ...
810-920 3.92e-07

Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK33 is highly expressed in the testis and is present in low levels in most tissues. It may be involved in spermatogenesis and organ ontogenesis. It interacts with and phosphorylates vimentin and may be involved in regulating intermediate filament cytoskeletal dynamics. Its role in promoting the cell viability of KRAS-dependent cancer cells is under debate; some studies have found STK33 to promote cancer cell viability, while other studies have found it to be non-essential. KRAS is the most commonly mutated human oncogene, thus, studies on the role of STK33 in KRAS mutant cancer cells are important. The STK33 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270999 [Multi-domain]  Cd Length: 266  Bit Score: 52.94  E-value: 3.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLIC------EGKL-VKICDFGLARDIMRDSNYISKGSTFLPLkWMAPESIFNSLYTT 882
Cdd:cd14097   109 LASAVAYLHKNDIVHRDLKLENILVKssiidnNDKLnIKVTDFGLSVQKYGLGEDMLQETCGTPI-YMAPEVISAHGYSQ 187
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 226342982  883 LSDVWSFGILLWeiFTLGGTPYPELPMNDQFYNAIKRG 920
Cdd:cd14097   188 QCDIWSIGVIMY--MLLCGEPPFVAKSEEKLFEEIRKG 223
STKc_CDK1_CdkB_like cd07835
Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of ...
805-903 3.95e-07

Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK, CDK2, and CDK3. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression while the CDK1/cyclin B complex is critical for G2 to M phase transition. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. Studies in knockout mice revealed that CDK1 can compensate for the loss of the cdk2 gene as it can also bind cyclin E and drive G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270829 [Multi-domain]  Cd Length: 283  Bit Score: 53.06  E-value: 3.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  805 GFSYQVANGMDFLASKNCVHRDLAARNVLI-CEGKLvKICDFGLARdimrdsnyiskgsTF-LPLK---------WM-AP 872
Cdd:cd07835   103 SYLYQLLQGIAFCHSHRVLHRDLKPQNLLIdTEGAL-KLADFGLAR-------------AFgVPVRtythevvtlWYrAP 168
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 226342982  873 ESIFNS-LYTTLSDVWSFGIL-------------------LWEIFTLGGTP 903
Cdd:cd07835   169 EILLGSkHYSTPVDIWSVGCIfaemvtrrplfpgdseidqLFRIFRTLGTP 219
STKc_p38delta cd07879
Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase ...
808-898 4.53e-07

Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38delta/MAPK13 is found in skeletal muscle, heart, lung, testis, pancreas, and small intestine. It regulates microtubule function by phosphorylating Tau. It activates the c-jun promoter and plays a role in G2 cell cycle arrest. It also controls the degration of c-Myb, which is associated with myeloid leukemia and poor prognosis in colorectal cancer. p38delta is the main isoform involved in regulating the differentiation and apoptosis of keratinocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143384 [Multi-domain]  Cd Length: 342  Bit Score: 53.37  E-value: 4.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdimrdsNYISKGSTFLPLKWM-APESIFNSL-YTTLSD 885
Cdd:cd07879   124 YQMLCGLKYIHSAGIIHRDLKPGNLAVNEDCELKILDFGLAR------HADAEMTGYVVTRWYrAPEVILNWMhYNQTVD 197
                          90
                  ....*....|...
gi 226342982  886 VWSFGILLWEIFT 898
Cdd:cd07879   198 IWSVGCIMAEMLT 210
STKc_DRAK1 cd14197
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
809-904 4.59e-07

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 (also called STK17A) and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. Rabbit DRAK1 has been shown to induce apoptosis in osteoclasts and overexpressio of human DRAK1 induces apoptosis in cultured fibroblast cells. DRAK1 may be involved in apoptotic signaling. The DRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271099 [Multi-domain]  Cd Length: 271  Bit Score: 52.63  E-value: 4.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLIC-EGKL--VKICDFGLARdIMRDSNYISK--GSTflplKWMAPESIFNSLYTTL 883
Cdd:cd14197   119 QILEGVSFLHNNNVVHLDLKPQNILLTsESPLgdIKIVDFGLSR-ILKNSEELREimGTP----EYVAPEILSYEPISTA 193
                          90       100
                  ....*....|....*....|.
gi 226342982  884 SDVWSFGILLWEIFTlGGTPY 904
Cdd:cd14197   194 TDMWSIGVLAYVMLT-GISPF 213
STKc_RIP2 cd14026
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze ...
604-951 4.62e-07

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP2, also called RICK or CARDIAK, harbors a C-terminal Caspase Activation and Recruitment domain (CARD) belonging to the Death domain (DD) superfamily. It functions as an effector kinase downstream of the pattern recognition receptors from the Nod-like (NLR) family, Nod1 and Nod2, which recognizes bacterial peptidoglycans released upon infection. RIP2 may also be involved in regulating wound healing and keratinocyte proliferation. RIP kinases serve as essential sensors of cellular stress. The RIP2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270928 [Multi-domain]  Cd Length: 284  Bit Score: 52.61  E-value: 4.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEAtahglSHSQATMKVAVKMLK--STARSSEKQALMSELKIMsHLGPHLNVVNLLGACTKGGPIYIIT 681
Cdd:cd14026     3 RYLSRGAFGTVSRA-----RHADWRVTVAIKCLKldSPVGDSERNCLLKEAEIL-HKARFSYILPILGICNEPEFLGIVT 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  682 EYCRYGDLVDYLHRnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmsKDEsidyvpmldmkgdi 761
Cdd:cd14026    77 EYMTNGSLNELLHE-------------------------------------------------KDI-------------- 93
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  762 kYADIESPsymapydnyvpsapertyratlindspvLSYTDLvgfsYQVANGMDFLASKN--CVHRDLAARNVLICEGKL 839
Cdd:cd14026    94 -YPDVAWP----------------------------LRLRIL----YEIALGVNYLHNMSppLLHHDLKTQNILLDGEFH 140
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  840 VKICDFGLARDIMRdSNYISKGSTFLP----LKWMAPESIFNSLYTTLS---DVWSFGILLWEIFTLgGTPYPELPMNDQ 912
Cdd:cd14026   141 VKIADFGLSKWRQL-SISQSRSSKSAPeggtIIYMPPEEYEPSQKRRASvkhDIYSYAIIMWEVLSR-KIPFEEVTNPLQ 218
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 226342982  913 FYNAIKRGYR---------MAQPAHASdeIYEIMQKCWEEKFETRPPF 951
Cdd:cd14026   219 IMYSVSQGHRpdtgedslpVDIPHRAT--LINLIESGWAQNPDERPSF 264
STKc_SnRK2-3 cd14665
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
806-939 5.06e-07

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2, group 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK2 is represented in this cd. SnRK2s are involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development. The SnRK2s subfamily is in turn classed into three subgroups, all 3 of which are represented in this CD. Group 1 comprises kinases not activated by ABA, group 2 - kinases not activated or activated very weakly by ABA (depending on plant species), and group 3 - kinases strongly activated by ABA. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271135 [Multi-domain]  Cd Length: 257  Bit Score: 52.30  E-value: 5.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLI--CEGKLVKICDFGLARDIMRDSNyiSKGSTFLPlKWMAPESIFNSLYT-T 882
Cdd:cd14665   101 FFQQLISGVSYCHSMQICHRDLKLENTLLdgSPAPRLKICDFGYSKSSVLHSQ--PKSTVGTP-AYIAPEVLLKKEYDgK 177
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982  883 LSDVWSFGILLWeIFTLGGTPY--PELPMNdqFYNAIKR----GYRMAQPAHASDEIYEIMQK 939
Cdd:cd14665   178 IADVWSCGVTLY-VMLVGAYPFedPEEPRN--FRKTIQRilsvQYSIPDYVHISPECRHLISR 237
STKc_CaMKK1 cd14200
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; ...
813-948 5.17e-07

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK1, also called CaMKK alpha, is involved in the regulation of glucose uptake in skeletal muscles, independently of AMPK and PKB activation. It also play roles in learning and memory. Studies on CaMKK1 knockout mice reveal deficits in fear conditioning. The CaMKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271102 [Multi-domain]  Cd Length: 284  Bit Score: 52.64  E-value: 5.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  813 GMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISkgSTFLPLKWMAPESIFN---SLYTTLSDVWSF 889
Cdd:cd14200   136 GIEYLHYQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDALLS--STAGTPAFMAPETLSDsgqSFSGKALDVWAM 213
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226342982  890 GILLWeIFTLGGTPYPelpmnDQF----YNAIK-RGYRMAQPAHASDEIYEIMQKCWEEKFETR 948
Cdd:cd14200   214 GVTLY-CFVYGKCPFI-----DEFilalHNKIKnKPVEFPEEPEISEELKDLILKMLDKNPETR 271
STKc_BMPR2_AMHR2 cd14054
Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and ...
810-898 5.36e-07

Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR2 and AMHR2 belong to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors (GDFs), and AMH, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. BMPR2 and AMHR2 act primarily as a receptor for BMPs and AMH, respectively. BMPs induce bone and cartilage formation, as well as regulate tooth, kidney, skin, hair, haematopoietic, and neuronal development. Mutations in BMPR2A is associated with familial pulmonary arterial hypertension. AMH is mainly responsible for the regression of Mullerian ducts during male sex differentiation. It is expressed exclusively by somatic cells of the gonads. Mutations in either AMH or AMHR2 cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism characterized by the presence of Mullerian derivatives (ovary and tubes) in otherwise normally masculine males. The BMPR2/AMHR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270956 [Multi-domain]  Cd Length: 300  Bit Score: 52.75  E-value: 5.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLAS--------KNCV-HRDLAARNVLI-CEGKLVkICDFGLA-----------RDIMRDSNYISKGSTflpLK 868
Cdd:cd14054   102 LTRGLAYLHTdlrrgdqyKPAIaHRDLNSRNVLVkADGSCV-ICDFGLAmvlrgsslvrgRPGAAENASISEVGT---LR 177
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 226342982  869 WMAPESIFNSL-------YTTLSDVWSFGILLWEIFT 898
Cdd:cd14054   178 YMAPEVLEGAVnlrdcesALKQVDVYALGLVLWEIAM 214
STKc_SnRK3 cd14663
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
809-919 5.44e-07

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK3 is represented in this cd. The SnRK3 group contains members also known as CBL-interacting protein kinase, salt overly sensitive 2, SOS3-interacting proteins and protein kinase S. These kinases interact with calcium-binding proteins such as SOS3, SCaBPs, and CBL proteins, and are involved in responses to salt stress and in sugar and ABA signaling. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271133 [Multi-domain]  Cd Length: 256  Bit Score: 52.41  E-value: 5.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLArdIMRDSNyisKGSTFL------PlKWMAPESIFNSLYT- 881
Cdd:cd14663   108 QLIDAVDYCHSRGVFHRDLKPENLLLDEDGNLKISDFGLS--ALSEQF---RQDGLLhttcgtP-NYVAPEVLARRGYDg 181
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 226342982  882 TLSDVWSFGILLWEIftLGGTpypeLPMNDQFYNAIKR 919
Cdd:cd14663   182 AKADIWSCGVILFVL--LAGY----LPFDDENLMALYR 213
STKc_MLCK2 cd14190
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze ...
763-904 5.75e-07

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK2 (or MYLK2) phosphorylates myosin regulatory light chain and controls the contraction of skeletal muscles. MLCK2 contains a single kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site. The MLCK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271092 [Multi-domain]  Cd Length: 261  Bit Score: 52.23  E-value: 5.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  763 YADIESPSYMAPYDNYVPSAP--ERtyratLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICE--GK 838
Cdd:cd14190    67 YEAIETPNEIVLFMEYVEGGElfER-----IVDEDYHLTEVDAMVFVRQICEGIQFMHQMRVLHLDLKPENILCVNrtGH 141
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226342982  839 LVKICDFGLARDIM-RDSNYISKGSTflplKWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPY 904
Cdd:cd14190   142 QVKIIDFGLARRYNpREKLKVNFGTP----EFLSPEVVNYDQVSFPTDMWSMGVITYMLLS-GLSPF 203
STKc_NUAK cd14073
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze ...
792-931 5.97e-07

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK1, also called ARK5 (AMPK-related protein kinase 5), regulates cell proliferation and displays tumor suppression through direct interaction and phosphorylation of p53. It is also involved in cell senescence and motility. High NUAK1 expression is associated with invasiveness of nonsmall cell lung cancer (NSCLC) and breast cancer cells. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. The NUAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270975 [Multi-domain]  Cd Length: 254  Bit Score: 52.01  E-value: 5.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  792 INDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLardimrdSNYISKG---STFL--P 866
Cdd:cd14073    92 ISERRRLPEREARRIFRQIVSAVHYCHKNGVVHRDLKLENILLDQNGNAKIADFGL-------SNLYSKDkllQTFCgsP 164
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  867 LkWMAPEsIFNSL--YTTLSDVWSFGILLweiFTLggtPYPELPMNDQFYNA----IKRG-YRmaQPAHASD 931
Cdd:cd14073   165 L-YASPE-IVNGTpyQGPEVDCWSLGVLL---YTL---VYGTMPFDGSDFKRlvkqISSGdYR--EPTQPSD 226
STKc_PKB_beta cd05595
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); ...
806-904 6.55e-07

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-beta is the predominant PKB isoform expressed in insulin-responsive tissues. It plays a critical role in the regulation of glucose homeostasis. It is also implicated in muscle cell differentiation. Mice deficient in PKB-beta display normal growth weights but exhibit severe insulin resistance and diabetes, accompanied by lipoatrophy and B-cell failure. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain.The PKB-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173686 [Multi-domain]  Cd Length: 323  Bit Score: 52.70  E-value: 6.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDimrdsnYISKGSTFLPL----KWMAPESIFNSLYT 881
Cdd:cd05595   100 YGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKE------GITDGATMKTFcgtpEYLAPEVLEDNDYG 173
                          90       100
                  ....*....|....*....|...
gi 226342982  882 TLSDVWSFGILLWEIFTlGGTPY 904
Cdd:cd05595   174 RAVDWWGLGVVMYEMMC-GRLPF 195
STKc_MAP4K3 cd06645
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
798-913 7.73e-07

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. MAP4K3 is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. mTOR regulates ribosome biogenesis and protein translation, and is frequently deregulated in cancer. MAP4Ks are involved in MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270812 [Multi-domain]  Cd Length: 272  Bit Score: 51.97  E-value: 7.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  798 LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrdSNYISKGSTFLPLK-WMAPESIF 876
Cdd:cd06645   105 LSESQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQI---TATIAKRKSFIGTPyWMAPEVAA 181
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 226342982  877 ---NSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQF 913
Cdd:cd06645   182 verKGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALF 221
STKc_DCKL3 cd14185
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called ...
602-939 7.83e-07

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL3 (or DCAMKL3) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. DCKL3 contains a single DCX domain (instead of a tandem) and a C-terminal kinase domain with similarity to CAMKs. It has been shown to interact with tubulin and JIP1/2. The DCKL3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271087 [Multi-domain]  Cd Length: 258  Bit Score: 51.87  E-value: 7.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  602 LGRTLGSGAFGQVVEAtahglSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIIT 681
Cdd:cd14185     4 IGRTIGDGNFAVVKEC-----RHWNENQEYAMKIIDKSKLKGKEDMIESEILIIKSLS-HPNIVKLFEVYETEKEIYLIL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  682 EYCRYGDLVDylhrnkhtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgdi 761
Cdd:cd14185    78 EYVRGGDLFD---------------------------------------------------------------------- 87
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  762 kyADIESPSYMAPydnyvpsapertyratlinDSPVLsYTDLvgfsyqvANGMDFLASKNCVHRDLAARNVLIC----EG 837
Cdd:cd14185    88 --AIIESVKFTEH-------------------DAALM-IIDL-------CEALVYIHSKHIVHRDLKPENLLVQhnpdKS 138
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  838 KLVKICDFGLARDIMRDSNYISKGSTFLplkwmAPESIFNSLYTTLSDVWSFGILLWeIFTLGGTPYPELPMN-DQFYNA 916
Cdd:cd14185   139 TTLKLADFGLAKYVTGPIFTVCGTPTYV-----APEILSEKGYGLEVDMWAAGVILY-ILLCGFPPFRSPERDqEELFQI 212
                         330       340
                  ....*....|....*....|....*.
gi 226342982  917 IKRG-YRMAQP--AHASDEIYEIMQK 939
Cdd:cd14185   213 IQLGhYEFLPPywDNISEAAKDLISR 238
STKc_SGK2 cd05603
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2; ...
806-939 8.02e-07

Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK2 shows a more restricted distribution than SGK1 and is most abundantly expressed in epithelial tissues including kidney, liver, pancreas, and the choroid plexus of the brain. In vitro cellular assays show that SGK2 can stimulate the activity of ion channels, the glutamate transporter EEAT4, and the glutamate receptors, GluR6 and GLUR1. The SGK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270754 [Multi-domain]  Cd Length: 321  Bit Score: 52.28  E-value: 8.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLI-CEGKLVkICDFGLARDIMRDSNyisKGSTFLPL-KWMAPESIFNSLYTTL 883
Cdd:cd05603   101 YAAEVASAIGYLHSLNIIYRDLKPENILLdCQGHVV-LTDFGLCKEGMEPEE---TTSTFCGTpEYLAPEVLRKEPYDRT 176
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226342982  884 SDVWSFGILLWEIFtLGGTPYPELPMNdQFYNAIkrgyrMAQPAH--------ASDEIYEIMQK 939
Cdd:cd05603   177 VDWWCLGAVLYEML-YGLPPFYSRDVS-QMYDNI-----LHKPLHlpggktvaACDLLQGLLHK 233
STKc_CDK8_like cd07842
Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs ...
785-899 8.19e-07

Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK8, CDC2L6, and similar proteins. CDK8 functions as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II-dependent transcription. CDC2L6 also associates with Mediator in complexes lacking CDK8. In VP16-dependent transcriptional activation, CDK8 and CDC2L6 exerts opposing effects by positive and negative regulation, respectively, in similar conditions. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK8-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270834 [Multi-domain]  Cd Length: 316  Bit Score: 52.29  E-value: 8.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  785 RTYRATLINDSPVLSYTdlvgfsYQVANGMDFLASKNCVHRDLAARNVLI----CEGKLVKICDFGLARDIMRDSNYISK 860
Cdd:cd07842    98 RQAKRVSIPPSMVKSLL------WQILNGIHYLHSNWVLHRDLKPANILVmgegPERGVVKIGDLGLARLFNAPLKPLAD 171
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 226342982  861 GS----TFlplkWM-APESIFNSL-YTTLSDVWSFGILLWEIFTL 899
Cdd:cd07842   172 LDpvvvTI----WYrAPELLLGARhYTKAIDIWAIGCIFAELLTL 212
STKc_GRK5 cd05632
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs ...
806-904 8.23e-07

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK5 is widely expressed in many tissues. It associates with the membrane though an N-terminal PIP2 binding domain and also binds phospholipids via its C-terminus. GRK5 deficiency is associated with early Alzheimer's disease in humans and mouse models. GRK5 also plays a crucial role in the pathogenesis of sporadic Parkinson's disease. It participates in the regulation and desensitization of PDGFRbeta, a receptor tyrosine kinase involved in a variety of downstream cellular effects including cell growth, chemotaxis, apoptosis, and angiogenesis. GRK5 also regulates Toll-like receptor 4, which is involved in innate and adaptive immunity. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270780 [Multi-domain]  Cd Length: 313  Bit Score: 52.28  E-value: 8.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTflpLKWMAPESIFNSLYTTLSD 885
Cdd:cd05632   109 YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGESIRGRVGT---VGYMAPEVLNNQRYTLSPD 185
                          90
                  ....*....|....*....
gi 226342982  886 VWSFGILLWEIFTlGGTPY 904
Cdd:cd05632   186 YWGLGCLIYEMIE-GQSPF 203
STKc_NAK_like cd14037
Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze ...
597-906 9.62e-07

Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Drosophila melanogaster NAK, human BMP-2-inducible protein kinase (BMP2K or BIKe) and similar vertebrate proteins, as well as the Saccharomyces cerevisiae proteins Prk1, Actin-regulating kinase 1 (Ark1), and Akl1. NAK was the first characterized member of this subfamily. It plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. BMP2K contains a nuclear localization signal and a kinase domain that is capable of phosphorylating itself and myelin basic protein. The expression of the BMP2K gene is increase during BMP-2-induced osteoblast differentiation. It may function to control the rate of differentiation. Prk1, Ark1, and Akl1 comprise a subfamily of yeast proteins that are important regulators of the actin cytoskeleton and endocytosis. They share an N-terminal kinase domain but no significant homology in other regions of their sequences. The NAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270939 [Multi-domain]  Cd Length: 277  Bit Score: 51.51  E-value: 9.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  597 RDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKmlkstaRSSEKQALMSELKIMSHLGPHLNVVNLLG---ACTK 673
Cdd:cd14037     2 SHHVTIEKYLAEGGFAHVYLVKTSNGGNRAALKRVYVN------DEHDLNVCKREIEIMKRLSGHKNIVGYIDssaNRSG 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  674 GG--PIYIITEYCRYGDLVDYLhrnkhtflqrhsNKHcppsaelysnaLPVGFSLPSHLNLtgesdggymdmskdesidy 751
Cdd:cd14037    76 NGvyEVLLLMEYCKGGGVIDLM------------NQR-----------LQTGLTESEILKI------------------- 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  752 vpmldmkgdikYADI-ESPSYMApydnyvpsapertYRATLIndspvlsytdlvgfsyqvangmdflaskncVHRDLAAR 830
Cdd:cd14037   114 -----------FCDVcEAVAAMH-------------YLKPPL------------------------------IHRDLKVE 139
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  831 NVLICEGKLVKICDFGLARDIMR------DSNY----ISKGSTflpLKWMAPESIfnSLY-----TTLSDVWSFGILLWE 895
Cdd:cd14037   140 NVLISDSGNYKLCDFGSATTKILppqtkqGVTYveedIKKYTT---LQYRAPEMI--DLYrgkpiTEKSDIWALGCLLYK 214
                         330
                  ....*....|...
gi 226342982  896 I--FTlggTPYPE 906
Cdd:cd14037   215 LcfYT---TPFEE 224
STKc_NUAK2 cd14161
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs ...
792-904 9.79e-07

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. NUAK2 is implicated in regulating actin stress fiber assembly through its association with myosin phosphatase Rho-interacting protein (MRIP), which leads to an increase in myosin regulatory light chain (MLC) phosphorylation. It is also associated with tumor growth, migration, and oncogenicity of melanoma cells. The NUAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271063 [Multi-domain]  Cd Length: 255  Bit Score: 51.49  E-value: 9.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  792 INDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLArDIMRDSNYISK--GStflPLkW 869
Cdd:cd14161    93 ISERQRLSELEARHFFRQIVSAVHYCHANGIVHRDLKLENILLDANGNIKIADFGLS-NLYNQDKFLQTycGS---PL-Y 167
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 226342982  870 MAPESIFNSLYTTLS-DVWSFGILLWeIFTLGGTPY 904
Cdd:cd14161   168 ASPEIVNGRPYIGPEvDSWSLGVLLY-ILVHGTMPF 202
STKc_TGFbR_I cd14056
Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type ...
824-950 9.96e-07

Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type I Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of type I receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation through trans-phosphorylation by type II receptors, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. They are inhibited by the immunophilin FKBP12, which is thought to control leaky signaling caused by receptor oligomerization in the absence of ligand. The TGFbR-I subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270958 [Multi-domain]  Cd Length: 287  Bit Score: 51.89  E-value: 9.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  824 HRDLAARNVLicegklVK------ICDFGLA------RDIMRDSNYISKGSTflplKWMAPESIFNSLYTT------LSD 885
Cdd:cd14056   123 HRDLKSKNIL------VKrdgtccIADLGLAvrydsdTNTIDIPPNPRVGTK----RYMAPEVLDDSINPKsfesfkMAD 192
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  886 VWSFGILLWEIF---TLGGT------PYPELPMNDQFYNAIK-----RGYRMAQPAHASD-----EIYEIMQKCWEEKFE 946
Cdd:cd14056   193 IYSFGLVLWEIArrcEIGGIaeeyqlPYFGMVPSDPSFEEMRkvvcvEKLRPPIPNRWKSdpvlrSMVKLMQECWSENPH 272

                  ....
gi 226342982  947 TRPP 950
Cdd:cd14056   273 ARLT 276
STKc_PLK1 cd14187
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the ...
809-949 9.99e-07

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. Its localization changes during mitotic progression; associating first with centrosomes in prophase, with kinetochores in prometaphase and metaphase, at the central spindle in anaphase, and in the midbody during telophase. It carries multiple functions throughout the cell cycle through interactions with differrent substrates at these specific subcellular locations. PLK1 is overexpressed in many human cancers and is associated with poor prognosis. The PLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271089 [Multi-domain]  Cd Length: 265  Bit Score: 51.47  E-value: 9.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNyiSKGSTFLPLKWMAPESIFNSLYTTLSDVWS 888
Cdd:cd14187   115 QIILGCQYLHRNRVIHRDLKLGNLFLNDDMEVKIGDFGLATKVEYDGE--RKKTLCGTPNYIAPEVLSKKGHSFEVDIWS 192
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226342982  889 FGILLWEIFtLGGTPYPELPMNDQFYNAIKRGYRMaqPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd14187   193 IGCIMYTLL-VGKPPFETSCLKETYLRIKKNEYSI--PKHINPVAASLIQKMLQTDPTARP 250
STKc_DRAK cd14106
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
790-904 1.01e-06

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs, also called STK17, were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. They may play a role in apoptotic signaling. The DRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271008 [Multi-domain]  Cd Length: 268  Bit Score: 51.58  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  790 TLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVL-----ICEGklVKICDFGLA---------RDIMRDS 855
Cdd:cd14106    97 TLLDEEECLTEADVRRLMRQILEGVQYLHERNIVHLDLKPQNILltsefPLGD--IKLCDFGISrvigegeeiREILGTP 174
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 226342982  856 NYIskgstflplkwmAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPY 904
Cdd:cd14106   175 DYV------------APEILSYEPISLATDMWSIGVLTYVLLT-GHSPF 210
STKc_MLCK1 cd14191
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze ...
791-904 1.02e-06

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK1 (or MYLK1) phosphorylates myosin regulatory light chain and controls the contraction of smooth muscles. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module which results in the expression of telokin in phasic smooth muscles, leading to Ca2+ desensitization by cyclic nucleotides of smooth muscle force. MLCK1 is also responsible for myosin regulatory light chain phosphorylation in nonmuscle cells and may play a role in regulating myosin II ATPase activity. The MLCK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271093 [Multi-domain]  Cd Length: 259  Bit Score: 51.54  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  791 LINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICE--GKLVKICDFGLARdimRDSNYISKGSTFLPLK 868
Cdd:cd14191    90 IIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNktGTKIKLIDFGLAR---RLENAGSLKVLFGTPE 166
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 226342982  869 WMAPESIFNSLYTTLSDVWSFGILLWeIFTLGGTPY 904
Cdd:cd14191   167 FVAPEVINYEPIGYATDMWSIGVICY-ILVSGLSPF 201
STKc_NIM1 cd14075
Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the ...
809-904 1.04e-06

Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIM1 is a widely-expressed kinase belonging to the AMP-activated protein kinase (AMPK) subfamily. Although present in most tissues, NIM1 kinase activity is only observed in the brain and testis. NIM1 is capable of autophosphorylating and activating itself, but may be present in other tissues in the inactive form. The physiological function of NIM1 has yet to be elucidated. The NIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270977 [Multi-domain]  Cd Length: 255  Bit Score: 51.18  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDsnyiSKGSTFL---PlkWMAPEsIF--NSLYTTL 883
Cdd:cd14075   109 QIVSAVKHMHENNIIHRDLKAENVFYASNNCVKVGDFGFSTHAKRG----ETLNTFCgspP--YAAPE-LFkdEHYIGIY 181
                          90       100
                  ....*....|....*....|.
gi 226342982  884 SDVWSFGILLWEIFTlGGTPY 904
Cdd:cd14075   182 VDIWALGVLLYFMVT-GVMPF 201
STKc_PFTAIRE2 cd07870
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer ...
806-903 1.04e-06

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-2 is also referred to as ALS2CR7 (amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 7). It may be associated with amyotrophic lateral sclerosis 2 (ALS2), an autosomal recessive form of juvenile ALS. The function of PFTAIRE-2 is not yet known. It shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270852 [Multi-domain]  Cd Length: 286  Bit Score: 51.89  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLI-CEGKLvKICDFGLARDIMRDSNYISkgSTFLPLKWMAPESIFNSL-YTTL 883
Cdd:cd07870   103 FMFQLLRGLAYIHGQHILHRDLKPQNLLIsYLGEL-KLADFGLARAKSIPSQTYS--SEVVTLWYRPPDVLLGATdYSSA 179
                          90       100
                  ....*....|....*....|
gi 226342982  884 SDVWSFGILLWEIFTlgGTP 903
Cdd:cd07870   180 LDIWGAGCIFIEMLQ--GQP 197
PKc_MEK2 cd06649
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
807-905 1.05e-06

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 2; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK2 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132980 [Multi-domain]  Cd Length: 331  Bit Score: 51.97  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  807 SYQVANGMDFLASKNCV-HRDLAARNVLICEGKLVKICDFGLARDIMRdsnyiSKGSTFLPLK-WMAPESIFNSLYTTLS 884
Cdd:cd06649   109 SIAVLRGLAYLREKHQImHRDVKPSNILVNSRGEIKLCDFGVSGQLID-----SMANSFVGTRsYMSPERLQGTHYSVQS 183
                          90       100
                  ....*....|....*....|.
gi 226342982  885 DVWSFGILLWEIfTLGGTPYP 905
Cdd:cd06649   184 DIWSMGLSLVEL-AIGRYPIP 203
STKc_GRK4 cd05631
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs ...
804-904 1.11e-06

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK4 has a limited tissue distribution. It is mainly found in the testis, but is also present in the cerebellum and kidney. It is expressed as multiple splice variants with different domain architectures and is post-translationally palmitoylated and localized in the membrane. GRK4 polymorphisms are associated with hypertension and salt sensitivity, as they cause hyperphosphorylation, desensitization, and internalization of the dopamine 1 (D1) receptor while increasing the expression of the angiotensin II type 1 receptor. GRK4 plays a crucial role in the D1 receptor regulation of sodium excretion and blood pressure. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173720 [Multi-domain]  Cd Length: 285  Bit Score: 51.53  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  804 VGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTflpLKWMAPESIFNSLYTTL 883
Cdd:cd05631   105 IFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLAVQIPEGETVRGRVGT---VGYMAPEVINNEKYTFS 181
                          90       100
                  ....*....|....*....|.
gi 226342982  884 SDVWSFGILLWEIFTlGGTPY 904
Cdd:cd05631   182 PDWWGLGCLIYEMIQ-GQSPF 201
STKc_cPKC_alpha cd05615
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs ...
804-936 1.14e-06

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-alpha is expressed in many tissues and is associated with cell proliferation, apoptosis, and cell motility. It plays a role in the signaling of the growth factors PDGF, VEGF, EGF, and FGF. Abnormal levels of PKC-alpha have been detected in many transformed cell lines and several human tumors. In addition, PKC-alpha is required for HER2 dependent breast cancer invasion. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. The cPKC-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270766 [Multi-domain]  Cd Length: 341  Bit Score: 51.92  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  804 VGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyISKGSTFLPLKWMAPESIFNSLYTTL 883
Cdd:cd05615   114 VFYAAEISVGLFFLHKKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMVEG--VTTRTFCGTPDYIAPEIIAYQPYGRS 191
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 226342982  884 SDVWSFGILLWEIftLGGTPYPELPMNDQFYNAIKRgYRMAQPAHASDEIYEI 936
Cdd:cd05615   192 VDWWAYGVLLYEM--LAGQPPFDGEDEDELFQSIME-HNVSYPKSLSKEAVSI 241
STKc_obscurin_rpt1 cd14107
Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
784-892 1.24e-06

Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271009 [Multi-domain]  Cd Length: 257  Bit Score: 51.04  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  784 ERTYRATLINDSPVLSYTDlvgfsyQVANGMDFLASKNCVHRDLAARNVLIC--EGKLVKICDFGLARDIMRDSNYISKG 861
Cdd:cd14107    87 DRLFLKGVVTEAEVKLYIQ------QVLEGIGYLHGMNILHLDIKPDNILMVspTREDIKICDFGFAQEITPSEHQFSKY 160
                          90       100       110
                  ....*....|....*....|....*....|.
gi 226342982  862 STflPlKWMAPESIFNSLYTTLSDVWSFGIL 892
Cdd:cd14107   161 GS--P-EFVAPEIVHQEPVSAATDIWALGVI 188
STKc_PLK3 cd14189
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the ...
809-919 1.26e-06

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK3, also called Prk or Fnk (FGF-inducible kinase), regulates angiogenesis and responses to DNA damage. Activated PLK3 mediates Chk2 phosphorylation by ATM and the resulting checkpoint activation. PLK3 phosphorylates DNA polymerase delta and may be involved in DNA repair. It also inhibits Cdc25c, thereby regulating the onset of mitosis. The PLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271091 [Multi-domain]  Cd Length: 255  Bit Score: 51.08  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWS 888
Cdd:cd14189   109 QIISGLKYLHLKGILHRDLKLGNFFINENMELKVGDFGLAARL--EPPEQRKKTICGTPNYLAPEVLLRQGHGPESDVWS 186
                          90       100       110
                  ....*....|....*....|....*....|.
gi 226342982  889 FGILLWEIftLGGTPYPELPMNDQFYNAIKR 919
Cdd:cd14189   187 LGCVMYTL--LCGNPPFETLDLKETYRCIKQ 215
STKc_GRK1 cd05608
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1; STKs ...
794-901 1.32e-06

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK1 (also called rhodopsin kinase) belongs to the visual group of GRKs and is expressed in retinal cells. It phosphorylates rhodopsin in rod cells, which leads to termination of the phototransduction cascade. Mutations in GRK1 are associated to a recessively inherited form of stationary nightblindness called Oguchi disease. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270759 [Multi-domain]  Cd Length: 288  Bit Score: 51.42  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  794 DSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDiMRDSNYISKGSTFLPlKWMAPE 873
Cdd:cd05608    98 ENPGFQEPRACFYTAQIISGLEHLHQRRIIYRDLKPENVLLDDDGNVRISDLGLAVE-LKDGQTKTKGYAGTP-GFMAPE 175
                          90       100
                  ....*....|....*....|....*...
gi 226342982  874 SIFNSLYTTLSDVWSFGILLWEIFTLGG 901
Cdd:cd05608   176 LLLGEEYDYSVDYFTLGVTLYEMIAARG 203
STKc_MLCK4 cd14193
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze ...
791-941 1.43e-06

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. MLCK4 (or MYLK4 or SgK085) contains a single kinase domain near the C-terminus. The MLCK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271095 [Multi-domain]  Cd Length: 261  Bit Score: 51.07  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  791 LINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLIC--EGKLVKICDFGLARDIM-RDSNYISKGSTflpl 867
Cdd:cd14193    92 IIDENYNLTELDTILFIKQICEGIQYMHQMYILHLDLKPENILCVsrEANQVKIIDFGLARRYKpREKLRVNFGTP---- 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  868 KWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYN--AIKRGYRMAQPAHASDEIYE------IMQK 939
Cdd:cd14193   168 EFLAPEVVNYEFVSFPTDMWSLGVIAYMLLS-GLSPFLGEDDNETLNNilACQWDFEDEEFADISEEAKDfiskllIKEK 246

                  ..
gi 226342982  940 CW 941
Cdd:cd14193   247 SW 248
STKc_PIM cd14005
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
809-953 1.45e-06

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 and three PIM2 isoforms as a result of alternative translation initiation sites, while there is only one PIM3 protein. Compound knockout mice deficient of all three PIM kinases that survive the perinatal period show a profound reduction in body size, indicating that PIMs are important for body growth. The PIM subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270907 [Multi-domain]  Cd Length: 255  Bit Score: 51.08  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKL-VKICDFGLArDIMRDSNYISKGST--FLPlkwmaPESIFNSLYTTLS- 884
Cdd:cd14005   115 QVVEAVRHCHQRGVLHRDIKDENLLINLRTGeVKLIDFGCG-ALLKDSVYTDFDGTrvYSP-----PEWIRHGRYHGRPa 188
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226342982  885 DVWSFGILLWEIFTlGGTPYpelpMNDQFynaIKRGYRMAQPaHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14005   189 TVWSLGILLYDMLC-GDIPF----ENDEQ---ILRGNVLFRP-RLSKECCDLISRCLQFDPSKRPSLEQ 248
STKc_DCKL cd14095
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called ...
802-920 1.48e-06

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called Doublecortin-like and CAM kinase-like); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL (or DCAMKL) proteins belong to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL proteins contain a C-terminal kinase domain with similarity to CAMKs. They are involved in the regulation of cAMP signaling. Vertebrates contain three DCKL proteins (DCKL1-3); DCKL1 and 2 also contain a serine, threonine, and proline rich domain (SP), while DCKL3 contains only a single DCX domain instead of tandem domains. The DCKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270997 [Multi-domain]  Cd Length: 258  Bit Score: 50.79  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  802 DLVGFSYQVANGMDFLASKNCVHRDLAARNVLICE----GKLVKICDFGLARdIMRDSNYISKGStflPlKWMAPESIFN 877
Cdd:cd14095    99 DASRMVTDLAQALKYLHSLSIVHRDIKPENLLVVEhedgSKSLKLADFGLAT-EVKEPLFTVCGT---P-TYVAPEILAE 173
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 226342982  878 SLYTTLSDVWSFGILLWEIftLGGTPYPELPMNDQ--FYNAIKRG 920
Cdd:cd14095   174 TGYGLKVDIWAAGVITYIL--LCGFPPFRSPDRDQeeLFDLILAG 216
STKc_JNK1 cd07875
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 1; STKs catalyze the ...
808-952 1.62e-06

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK1 is expressed in every cell and tissue type. It specifically binds with JAMP (JNK1-associated membrane protein), which regulates the duration of JNK1 activity in response to stimuli. Specific JNK1 substrates include Itch and SG10, which are implicated in Th2 responses and airway inflammation, and microtubule dynamics and axodendritic length, respectively. Mice deficient in JNK1 are protected against arthritis, obesity, type 2 diabetes, cardiac cell death, and non-alcoholic liver disease, suggesting that JNK1 may play roles in the pathogenesis of these diseases. Initially, it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143380 [Multi-domain]  Cd Length: 364  Bit Score: 51.58  E-value: 1.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdimrdsnyiSKGSTFLPLKWM------APESIFNSLYT 881
Cdd:cd07875   133 YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR---------TAGTSFMMTPYVvtryyrAPEVILGMGYK 203
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226342982  882 TLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKrgyrmaQPAHASDEIYEIMQKCWEEKFETRPPFS 952
Cdd:cd07875   204 ENVDIWSVGCIMGEMIK-GGVLFPGTDHIDQWNKVIE------QLGTPCPEFMKKLQPTVRTYVENRPKYA 267
STKc_PRP4 cd14135
Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4; STKs catalyze ...
820-898 1.70e-06

Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PRP4 phosphorylates a number of factors involved in the formation of active spliceosomes, which catalyze pre-mRNA splicing. It phosphorylates PRP6 and PRP31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), during spliceosomal complex formation. In fission yeast, PRP4 phosphorylates the splicing factor PRP1 (U5-102 kD in mammals). Thus, PRP4 plays a key role in regulating spliceosome assembly and pre-mRNA splicing. It also plays an important role in mitosis by acting as a spindle assembly checkpoint kinase that is required for chromosome alignment and the recruitment of the checkpoint proteins MPS1, MAD1, and MAD2 at kinetochores. The PRP4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271037 [Multi-domain]  Cd Length: 318  Bit Score: 51.45  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  820 KNC--VHRDLAARNVLICEGKLV-KICDFGLARDImrDSNYISK--GSTFlplkWMAPESIFNSLYTTLSDVWSFGILLW 894
Cdd:cd14135   122 KKCniLHADIKPDNILVNEKKNTlKLCDFGSASDI--GENEITPylVSRF----YRAPEIILGLPYDYPIDMWSVGCTLY 195

                  ....
gi 226342982  895 EIFT 898
Cdd:cd14135   196 ELYT 199
STKc_MEKK3 cd06651
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
806-953 1.78e-06

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK3 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. In addition, MEKK3 is involved in interleukin-1 receptor and Toll-like receptor 4 signaling. It is also a specific regulator of the proinflammatory cytokines IL-6 and GM-CSF in some immune cells. MEKK3 also regulates calcineurin, which plays a critical role in T cell activation, apoptosis, skeletal myocyte differentiation, and cardiac hypertrophy. The MEKK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270817 [Multi-domain]  Cd Length: 271  Bit Score: 50.85  E-value: 1.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMR--DSNYISKGSTFLPLkWMAPESIFNSLYTTL 883
Cdd:cd06651   116 YTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTicMSGTGIRSVTGTPY-WMSPEVISGEGYGRK 194
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  884 SDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKfETRP--------PFSQ 953
Cdd:cd06651   195 ADVWSLGCTVVEMLT-EKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHARDFLGCIFVEA-RHRPsaeellrhPFAQ 270
STKc_ACVR1_ALK1 cd14142
Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin ...
824-941 2.04e-06

Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR1, also called Activin receptor-Like Kinase 2 (ALK2), and ALK1 act as receptors for bone morphogenetic proteins (BMPs) and they activate SMAD1/5/8. ACVR1 is widely expressed while ALK1 is limited mainly to endothelial cells. The specificity of BMP binding to type I receptors is affected by type II receptors. ACVR1 binds BMP6/7/9/10 and can also bind anti-Mullerian hormone (AMH) in the presence of AMHR2. ALK1 binds BMP9/10 as well as TGFbeta in endothelial cells. A missense mutation in the GS domain of ACVR1 causes fibrodysplasia ossificans progressiva, a complex and disabling disease characterized by congenital skeletal malformations and extraskeletal bone formation. ACVR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and AMH, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like ACVR1 and ALK1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The ACVR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271044 [Multi-domain]  Cd Length: 298  Bit Score: 50.90  E-value: 2.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  824 HRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGST--FLPLKWMAPESIFNSLYTTL------SDVWSFGILLWE 895
Cdd:cd14142   133 HRDLKSKNILVKSNGQCCIADLGLAVTHSQETNQLDVGNNprVGTKRYMAPEVLDETINTDCfesykrVDIYAFGLVLWE 212
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  896 I---FTLGGT------PYPELPMNDQFYNAIKR-----GYRMAQPAH-ASDEIY----EIMQKCW 941
Cdd:cd14142   213 VarrCVSGGIveeykpPFYDVVPSDPSFEDMRKvvcvdQQRPNIPNRwSSDPTLtamaKLMKECW 277
PK_KSR2 cd14153
Pseudokinase domain of Kinase Suppressor of Ras 2; The pseudokinase domain shows similarity to ...
785-953 2.23e-06

Pseudokinase domain of Kinase Suppressor of Ras 2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. KSR2 interacts with the protein phosphatase calcineurin and functions in calcium-mediated ERK signaling. It also functions in energy metabolism by regulating AMP kinase and AMPK-dependent processes such as glucose uptake and fatty acid oxidation. KSR proteins act as scaffold proteins that function downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases. The KSR2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271055 [Multi-domain]  Cd Length: 270  Bit Score: 50.39  E-value: 2.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  785 RTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVkICDFGL-----------ARDIMR 853
Cdd:cd14153    81 RTLYSVVRDAKVVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVV-ITDFGLftisgvlqagrREDKLR 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  854 -DSNYISKGSTFLpLKWMAPESIFNSL-YTTLSDVWSFGILLWEIFTlggtpyPELPMNDQFYNAI----KRGYR--MAQ 925
Cdd:cd14153   160 iQSGWLCHLAPEI-IRQLSPETEEDKLpFSKHSDVFAFGTIWYELHA------REWPFKTQPAEAIiwqvGSGMKpnLSQ 232
                         170       180
                  ....*....|....*....|....*...
gi 226342982  926 PAHASdEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14153   233 IGMGK-EISDILLFCWAYEQEERPTFSK 259
STKc_MLCK3 cd14192
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze ...
791-904 2.26e-06

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK3 (or MYLK3) phosphorylates myosin regulatory light chain 2 and controls the contraction of cardiac muscles. It is expressed specifically in both the atrium and ventricle of the heart and its expression is regulated by the cardiac protein Nkx2-5. MLCK3 plays an important role in cardiogenesis by regulating the assembly of cardiac sarcomeres, the repeating contractile unit of striated muscle. MLCK3 contains a single kinase domain near the C-terminus and a unique N-terminal half, and unlike MLCK1/2, it does not appear to be regulated by Ca2+/calmodulin. The MLCK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271094 [Multi-domain]  Cd Length: 261  Bit Score: 50.35  E-value: 2.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  791 LINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICE--GKLVKICDFGLARDIM-RDSNYISKGSTflpl 867
Cdd:cd14192    92 ITDESYQLTELDAILFTRQICEGVHYLHQHYILHLDLKPENILCVNstGNQIKIIDFGLARRYKpREKLKVNFGTP---- 167
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 226342982  868 KWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPY 904
Cdd:cd14192   168 EFLAPEVVNYDFVSFPTDMWSVGVITYMLLS-GLSPF 203
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
230-307 2.55e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 46.17  E-value: 2.55e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  230 ITIRCIVMGNDVVNFQWtyprMKSGRLVEPVTDYLFGVPSRIGSiLHIPTAELSDSGTYTCNVSvsvNDHGDEKAINI 307
Cdd:cd00096     1 VTLTCSASGNPPPTITW----YKNGKPLPPSSRDSRRSELGNGT-LTISNVTLEDSGTYTCVAS---NSAGGSASASV 70
PK_GC_unk cd14045
Pseudokinase domain of the unknown subfamily of membrane Guanylate Cyclase receptors; The ...
783-953 2.64e-06

Pseudokinase domain of the unknown subfamily of membrane Guanylate Cyclase receptors; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs lack a critical aspartate involved in ATP binding and does not exhibit kinase activity. It functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270947 [Multi-domain]  Cd Length: 269  Bit Score: 50.24  E-value: 2.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  783 PERTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLArdIMRDSNYISKGS 862
Cdd:cd14045    85 PKGSLNDVLLNEDIPLNWGFRFSFATDIARGMAYLHQHKIYHGRLKSSNCVIDDRWVCKIADYGLT--TYRKEDGSENAS 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  863 TF---LPLKWMAPE--SIFNSLYTTLSDVWSFGILLWEIFTLgGTPYPE----------LPMNDQFYNaiKRGYRMAQPA 927
Cdd:cd14045   163 GYqqrLMQVYLPPEnhSNTDTEPTQATDVYSYAIILLEIATR-NDPVPEddysldeawcPPLPELISG--KTENSCPCPA 239
                         170       180
                  ....*....|....*....|....*.
gi 226342982  928 hasdEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14045   240 ----DYVELIRRCRKNNPAQRPTFEQ 261
STKc_CaMKI_alpha cd14167
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
808-945 2.68e-06

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271069 [Multi-domain]  Cd Length: 263  Bit Score: 50.03  E-value: 2.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVL---ICEGKLVKICDFGLARdiMRDSNYISKGSTFLPlKWMAPESIFNSLYTTLS 884
Cdd:cd14167   108 FQILDAVKYLHDMGIVHRDLKPENLLyysLDEDSKIMISDFGLSK--IEGSGSVMSTACGTP-GYVAPEVLAQKPYSKAV 184
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226342982  885 DVWSFGILLWeIFTLGGTPYPELPMNDQFYNAIKRGYRMAQP------AHASDEIYEIMQKCWEEKF 945
Cdd:cd14167   185 DCWSIGVIAY-ILLCGYPPFYDENDAKLFEQILKAEYEFDSPywddisDSAKDFIQHLMEKDPEKRF 250
STKc_CDK9 cd07865
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs ...
809-898 2.97e-06

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK9, together with a cyclin partner (cyclin T1, T2a, T2b, or K), is the main component of distinct positive transcription elongation factors (P-TEFb), which function as Ser2 C-terminal domain kinases of RNA polymerase II. P-TEFb participates in multiple steps of gene expression including transcription elongation, mRNA synthesis, processing, export, and translation. It also plays a role in mediating cytokine induced transcription networks such as IL6-induced STAT3 signaling. In addition, the CDK9/cyclin T2a complex promotes muscle differentiation and enhances the function of some myogenic regulatory factors. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270848 [Multi-domain]  Cd Length: 310  Bit Score: 50.45  E-value: 2.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSN-----YISKGSTflpLKWMAPESIFNSL-YTT 882
Cdd:cd07865   127 MLLNGLYYIHRNKILHRDMKAANILITKDGVLKLADFGLARAFSLAKNsqpnrYTNRVVT---LWYRPPELLLGERdYGP 203
                          90
                  ....*....|....*.
gi 226342982  883 LSDVWSFGILLWEIFT 898
Cdd:cd07865   204 PIDMWGAGCIMAEMWT 219
STKc_SPEG_rpt1 cd14108
Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle ...
784-904 3.14e-06

Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Striated muscle preferentially expressed gene (SPEG) generates 4 different isoforms through alternative promoter use and splicing in a tissue-specific manner: SPEGalpha and SPEGbeta are expressed in cardiac and skeletal striated muscle; Aortic Preferentially Expressed Protein-1 (APEG-1) is expressed in vascular smooth muscle; and Brain preferentially expressed gene (BPEG) is found in the brain and aorta. SPEG proteins have mutliple immunoglobulin (Ig), 2 fibronectin type III (FN3), and two kinase domains. They are necessary for cardiac development and survival. The SPEG subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271010 [Multi-domain]  Cd Length: 255  Bit Score: 49.90  E-value: 3.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  784 ERTYRATLINDSPVLSYTDlvgfsyQVANGMDFLASKNCVHRDLAARNVLICEGKL--VKICDFGLARDIMRDSNYISKG 861
Cdd:cd14108    86 ERITKRPTVCESEVRSYMR------QLLEGIEYLHQNDVLHLDLKPENLLMADQKTdqVRICDFGNAQELTPNEPQYCKY 159
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 226342982  862 STflPlKWMAPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPY 904
Cdd:cd14108   160 GT--P-EFVAPEIVNQSPVSKVTDIWPVGVIAYLCLT-GISPF 198
STKc_obscurin_rpt2 cd14110
Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
781-892 3.24e-06

Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271012 [Multi-domain]  Cd Length: 257  Bit Score: 49.92  E-value: 3.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  781 SAPERTYRATLINDSPVLSYTDLVgfsYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYIS- 859
Cdd:cd14110    82 SGPELLYNLAERNSYSEAEVTDYL---WQILSAVDYLHSRRILHLDLRSENMIITEKNLLKIVDLGNAQPFNQGKVLMTd 158
                          90       100       110
                  ....*....|....*....|....*....|....
gi 226342982  860 -KGSTFLPlkwMAPESIFNSLYTTLSDVWSFGIL 892
Cdd:cd14110   159 kKGDYVET---MAPELLEGQGAGPQTDIWAIGVT 189
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
791-904 3.32e-06

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 50.95  E-value: 3.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  791 LINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI----MRDSN-------YIS 859
Cdd:NF033483   97 YIREHGPLSPEEAVEIMIQILSALEHAHRNGIVHRDIKPQNILITKDGRVKVTDFGIARALssttMTQTNsvlgtvhYLS 176
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 226342982  860 kgstflplkwmaPESIFNSLYTTLSDVWSFGILLWEIFTlGGTPY 904
Cdd:NF033483  177 ------------PEQARGGTVDARSDIYSLGIVLYEMLT-GRPPF 208
STKc_IRE1 cd13982
Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze ...
808-904 3.50e-06

Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), is an ER-localized type I transmembrane protein with kinase and endoribonuclease domains in the cytoplasmic side. It acts as an ER stress sensor and is the oldest and most conserved component of the unfolded protein response (UPR) in eukaryotes. The UPR is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. During ER stress, IRE1 dimerizes and forms oligomers, allowing the kinase domain to undergo trans-autophosphorylation. This leads to a conformational change that stimulates its endoribonuclease activity and results in the cleavage of its mRNA substrate, HAC1 in yeast and XBP1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. Mammals contain two IRE1 proteins, IRE1alpha (or ERN1) and IRE1beta (or ERN2). The Ire1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270884 [Multi-domain]  Cd Length: 269  Bit Score: 49.96  E-value: 3.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLI----CEGKL-VKICDFGLAR--DIMRDSnYISKGSTFLPLKWMAPESIFNSLY 880
Cdd:cd13982   106 RQIASGLAHLHSLNIVHRDLKPQNILIstpnAHGNVrAMISDFGLCKklDVGRSS-FSRRSGVAGTSGWIAPEMLSGSTK 184
                          90       100
                  ....*....|....*....|....*..
gi 226342982  881 TTLS---DVWSFGILLWEIFTLGGTPY 904
Cdd:cd13982   185 RRQTravDIFSLGCVFYYVLSGGSHPF 211
PTZ00426 PTZ00426
cAMP-dependent protein kinase catalytic subunit; Provisional
806-904 3.50e-06

cAMP-dependent protein kinase catalytic subunit; Provisional


Pssm-ID: 173616 [Multi-domain]  Cd Length: 340  Bit Score: 50.36  E-value: 3.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdIMRDSNYISKGSTflplKWMAPESIFNSLYTTLSD 885
Cdd:PTZ00426  136 YAAQIVLIFEYLQSLNIVYRDLKPENLLLDKDGFIKMTDFGFAK-VVDTRTYTLCGTP----EYIAPEILLNVGHGKAAD 210
                          90
                  ....*....|....*....
gi 226342982  886 VWSFGILLWEIFtLGGTPY 904
Cdd:PTZ00426  211 WWTLGIFIYEIL-VGCPPF 228
STKc_CaMKK2 cd14199
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; ...
791-948 3.55e-06

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK2, also called CaMKK beta, is one of the most versatile CaMKs. It is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. CaMKK2 contains unique N- and C-terminal domains and a central catalytic kinase domain that is followed by a regulatory domain that bears overlapping autoinhibitory and CaM-binding regions. It can be activated by signaling through G-coupled receptors, IP3 receptors, plasma membrane ion channels, and Toll-like receptors. Thus, CaMKK2 acts as a molecular hub that is capable of receiving and decoding signals from diverse pathways. The CaMKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271101 [Multi-domain]  Cd Length: 286  Bit Score: 49.96  E-value: 3.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  791 LINDSPVLSY-------TDLVGFSYQ-VANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISkgS 862
Cdd:cd14199   108 LVKQGPVMEVptlkplsEDQARFYFQdLIKGIEYLHYQKIIHRDVKPSNLLVGEDGHIKIADFGVSNEFEGSDALLT--N 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  863 TFLPLKWMAPESIFNS---LYTTLSDVWSFGILLWeIFTLGGTPYpelpMNDQ---FYNAIK-RGYRMAQPAHASDEIYE 935
Cdd:cd14199   186 TVGTPAFMAPETLSETrkiFSGKALDVWAMGVTLY-CFVFGQCPF----MDERilsLHSKIKtQPLEFPDQPDISDDLKD 260
                         170
                  ....*....|...
gi 226342982  936 IMQKCWEEKFETR 948
Cdd:cd14199   261 LLFRMLDKNPESR 273
STKc_MAST cd05609
Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine ...
813-904 3.71e-06

Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. There are four mammalian MAST kinases, named MAST1-MAST4. MAST1 is also called syntrophin-associated STK (SAST) while MAST2 is also called MAST205. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MAST1, MAST2, and MAST3 bind and phosphorylate the tumor suppressor PTEN, and may contribute to the regulation and stabilization of PTEN. MAST2 is involved in the regulation of the Fc-gamma receptor of the innate immune response in macrophages, and may also be involved in the regulation of the Na+/H+ exchanger NHE3. The MAST kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270760 [Multi-domain]  Cd Length: 280  Bit Score: 50.10  E-value: 3.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  813 GMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLAR-------------DIMRDSNYISKGSTFLPLKWMAPESIFNSL 879
Cdd:cd05609   112 ALEYLHSYGIVHRDLKPDNLLITSMGHIKLTDFGLSKiglmslttnlyegHIEKDTREFLDKQVCGTPEYIAPEVILRQG 191
                          90       100
                  ....*....|....*....|....*
gi 226342982  880 YTTLSDVWSFGILLWEiFTLGGTPY 904
Cdd:cd05609   192 YGKPVDWWAMGIILYE-FLVGCVPF 215
PHA03209 PHA03209
serine/threonine kinase US3; Provisional
809-914 3.90e-06

serine/threonine kinase US3; Provisional


Pssm-ID: 177557 [Multi-domain]  Cd Length: 357  Bit Score: 50.26  E-value: 3.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTflpLKWMAPESIFNSLYTTLSDVWS 888
Cdd:PHA03209  165 QILEGLRYLHAQRIIHRDVKTENIFINDVDQVCIGDLGAAQFPVVAPAFLGLAGT---VETNAPEVLARDKYNSKADIWS 241
                          90       100
                  ....*....|....*....|....*.
gi 226342982  889 FGILLWEIFTLGGTPYPELPMNDQFY 914
Cdd:PHA03209  242 AGIVLFEMLAYPSTIFEDPPSTPEEY 267
STKc_BMPR1b cd14219
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB; STKs ...
824-948 4.12e-06

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1b, also called Activin receptor-Like Kinase 6 (ALK6), functions as a receptor for bone morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Mutations in BMPR1b that led to inhibition of chondrogenesis can cause Brachydactyly (BD) type A2, a dominant hand malformation characterized by shortening and lateral deviation of the index fingers. A point mutation in the BMPR1b kinase domain is also associated with the Booroola phenotype, characterized by precocious differentiation of ovarian follicles. BMPR1b belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1b, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1b subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271121 [Multi-domain]  Cd Length: 305  Bit Score: 50.05  E-value: 4.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  824 HRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISkgstfLPL-------KWMAPESIFNSLYTT------LSDVWSFG 890
Cdd:cd14219   133 HRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVD-----IPPntrvgtkRYMPPEVLDESLNRNhfqsyiMADMYSFG 207
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226342982  891 ILLWEIF---TLGGT------PYPELPMNDQFYNAIK-----RGYRMAQPAH-ASDE----IYEIMQKCWEEKFETR 948
Cdd:cd14219   208 LILWEVArrcVSGGIveeyqlPYHDLVPSDPSYEDMReivciKRLRPSFPNRwSSDEclrqMGKLMTECWAHNPASR 284
PHA02988 PHA02988
hypothetical protein; Provisional
875-949 4.13e-06

hypothetical protein; Provisional


Pssm-ID: 165291 [Multi-domain]  Cd Length: 283  Bit Score: 49.74  E-value: 4.13e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  875 IFNSlYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:PHA02988  195 IFSE-YTIKDDIYSLGVVLWEIFT-GKIPFENLTTKEIYDLIINKNNSLKLPLDCPLEIKCIVEACTSHDSIKRP 267
STKc_PCTAIRE_like cd07844
Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
806-922 4.58e-06

Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-like proteins show unusual expression patterns with high levels in post-mitotic tissues, suggesting that they may be involved in regulating post-mitotic cellular events. They share sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The association of PCTAIRE-like proteins with cyclins has not been widely studied, although PFTAIRE-1 has been shown to function as a CDK which is regulated by cyclin D3 as well as the membrane-associated cyclin Y. The PCTAIRE-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270835 [Multi-domain]  Cd Length: 286  Bit Score: 49.69  E-value: 4.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLplkWMAPESIF--NSLYTTL 883
Cdd:cd07844   103 FLFQLLRGLAYCHQRRVLHRDLKPQNLLISERGELKLADFGLARAKSVPSKTYSNEVVTL---WYRPPDVLlgSTEYSTS 179
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982  884 SDVWSFGILLWE--------------------IFTLGGTP----YPELPMNDQFYNAIKRGYR 922
Cdd:cd07844   180 LDMWGVGCIFYEmatgrplfpgstdvedqlhkIFRVLGTPteetWPGVSSNPEFKPYSFPFYP 242
STKc_MARK cd14072
Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; ...
602-693 4.67e-06

Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MARKs, also called Partitioning-defective 1 (Par1) proteins, function as regulators of diverse cellular processes in nematodes, Drosophila, yeast, and vertebrates. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. Vertebrates contain four isoforms, namely MARK1 (or Par1c), MARK2 (or Par1b), MARK3 (Par1a), and MARK4 (or MARKL1). Known substrates of MARKs include the cell cycle-regulating phosphatase Cdc25, tyrosine phosphatase PTPH1, MAPK scaffolding protein KSR1, class IIa histone deacetylases, and plakophilin 2. The MARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270974 [Multi-domain]  Cd Length: 253  Bit Score: 49.44  E-value: 4.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  602 LGRTLGSGAFGQVVEAtahglSHSQATMKVAVKMLKSTARS-SEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYII 680
Cdd:cd14072     4 LLKTIGKGNFAKVKLA-----RHVLTGREVAIKIIDKTQLNpSSLQKLFREVRIMKILN-HPNIVKLFEVIETEKTLYLV 77
                          90
                  ....*....|...
gi 226342982  681 TEYCRYGDLVDYL 693
Cdd:cd14072    78 MEYASGGEVFDYL 90
STKc_DRAK2 cd14198
The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
798-904 4.96e-06

The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2 (also called STK17B). Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. DRAK2 has been implicated in inducing or enhancing apoptosis in beta cells, fibroblasts, and lymphoid cells, where it is highly expressed. It is involved in regulating many immune processes including the germinal center (GC) reaction, responses to thymus-dependent antigens, activated T cell survival, memory T cell responses. It may be involved in the development of autoimmunity. The DRAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271100 [Multi-domain]  Cd Length: 270  Bit Score: 49.54  E-value: 4.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  798 LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICE----GKlVKICDFGLARDIMRDSNYISKGSTflpLKWMAPE 873
Cdd:cd14198   107 VSENDIIRLIRQILEGVYYLHQNNIVHLDLKPQNILLSSiyplGD-IKIVDFGMSRKIGHACELREIMGT---PEYLAPE 182
                          90       100       110
                  ....*....|....*....|....*....|.
gi 226342982  874 SIFNSLYTTLSDVWSFGILLWEIFTlGGTPY 904
Cdd:cd14198   183 ILNYDPITTATDMWNIGVIAYMLLT-HESPF 212
STKc_PhKG cd14093
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs ...
809-899 5.03e-06

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). Each subunit has tissue-specific isoforms or splice variants. Vertebrates contain two isoforms of the gamma subunit (gamma 1 and gamma 2). The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270995 [Multi-domain]  Cd Length: 272  Bit Score: 49.27  E-value: 5.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRdsnyiskGSTFLPL----KWMAPESIFNSLYTTLS 884
Cdd:cd14093   117 QLFEAVEFLHSLNIVHRDLKPENILLDDNLNVKISDFGFATRLDE-------GEKLRELcgtpGYLAPEVLKCSMYDNAP 189
                          90       100
                  ....*....|....*....|.
gi 226342982  885 ------DVWSFGILLweiFTL 899
Cdd:cd14093   190 gygkevDMWACGVIM---YTL 207
STKc_TGFbR-like cd13998
Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; ...
823-948 5.17e-06

Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. There are two types of TGFbeta receptors included in this subfamily, I and II, that play different roles in signaling. For signaling to occur, the ligand first binds to the high-affinity type II receptor, which is followed by the recruitment of the low-affinity type I receptor to the complex and its activation through trans-phosphorylation by the type II receptor. The active type I receptor kinase starts intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. Different ligands interact with various combinations of types I and II receptors to elicit a specific signaling pathway. Activins primarily signal through combinations of ACVR1b/ALK7 and ACVR2a/b; myostatin and GDF11 through TGFbR1/ALK4 and ACVR2a/b; BMPs through ACVR1/ALK1 and BMPR2; and TGFbeta through TGFbR1 and TGFbR2. The TGFbR-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270900 [Multi-domain]  Cd Length: 289  Bit Score: 49.74  E-value: 5.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  823 VHRDLAARNVLICEGKLVKICDFGLArdiMRDSNYISKG-----STFLPLKWMAPE--------SIFNSLYTTlsDVWSF 889
Cdd:cd13998   123 AHRDLKSKNILVKNDGTCCIADFGLA---VRLSPSTGEEdnannGQVGTKRYMAPEvlegainlRDFESFKRV--DIYAM 197
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226342982  890 GILLWEIF---TLGGTPYPE--LPMNDQFYN-----------AIKRGYRMAQPAHASDE----IYEIMQKCWEEKFETR 948
Cdd:cd13998   198 GLVLWEMAsrcTDLFGIVEEykPPFYSEVPNhpsfedmqevvVRDKQRPNIPNRWLSHPglqsLAETIEECWDHDAEAR 276
IgI_VEGFR cd05862
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); ...
226-293 5.27e-06

Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R). The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. The VEGFR family consists of three members, VEGFR-1 (also known as Flt-1), VEGFR-2 (also known as KDR or Flk-1) and VEGFR-3 (also known as Flt-4). VEGF_A interacts with both VEGFR-1 and VEGFR-2. VEGFR-1 binds strongest to VEGF, VEGF-2 binds more weakly. VEGFR-3 appears not to bind VEGF, but binds other members of the VEGF family (VEGF-C and -D). VEGFRs bind VEGFs with high affinity with the IG-like domains. VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGFR-2 is a major mediator of the mitogenic, angiogenic and microvascular permeability-enhancing effects of VEGF-A. VEGFR-1 may play an inhibitory part in these processes by binding VEGF and interfering with its interaction with VEGFR-2. VEGFR-1 has a signaling role in mediating monocyte chemotaxis. VEGFR-2 and -1 may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. VEGFR-3 has been shown to be involved in tumor angiogenesis and growth.


Pssm-ID: 409448  Cd Length: 102  Bit Score: 46.28  E-value: 5.27e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  226 QGESITIRCIVMG--NDVVNFQWTYP--RMKSGRLVEPVTDYLFGVPSRIGSILHIPTAELSDSGTYTCNVS 293
Cdd:cd05862    15 VGEKLVLNCTARTelNVGVDFQWDYPgkKEQRRASVRRRRKQQSSEATEFSSTLTIDNVTLSDKGLYTCAAS 86
STKc_PAK5 cd06658
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the ...
810-908 5.42e-06

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK5 is mainly expressed in the brain. It is not required for viability, but together with PAK6, it is required for normal levels of locomotion and activity, and for learning and memory. PAK5 cooperates with Inca (induced in neural crest by AP2) in the regulation of cell adhesion and cytoskeletal organization in the embryo and in neural crest cells during craniofacial development. PAK5 may also play a role in controlling the signaling of Raf-1, an effector of Ras, at the mitochondria. PAK5 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132989 [Multi-domain]  Cd Length: 292  Bit Score: 49.65  E-value: 5.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDsnyISKGSTFLPLK-WMAPESIFNSLYTTLSDVWS 888
Cdd:cd06658   127 VLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKE---VPKRKSLVGTPyWMAPEVISRLPYGTEVDIWS 203
                          90       100
                  ....*....|....*....|
gi 226342982  889 FGILLWEIFTlGGTPYPELP 908
Cdd:cd06658   204 LGIMVIEMID-GEPPYFNEP 222
STKc_PKB_gamma cd05593
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3); ...
806-904 7.55e-06

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-gamma is predominantly expressed in neuronal tissues. Mice deficient in PKB-gamma show a reduction in brain weight due to the decreases in cell size and cell number. PKB-gamma has also been shown to be upregulated in estrogen-deficient breast cancer cells, androgen-independent prostate cancer cells, and primary ovarian tumors. It acts as a key mediator in the genesis of ovarian cancer. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. The PKB-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270745 [Multi-domain]  Cd Length: 348  Bit Score: 49.31  E-value: 7.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYIskgSTFLPL-KWMAPESIFNSLYTTLS 884
Cdd:cd05593   120 YGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATM---KTFCGTpEYLAPEVLEDNDYGRAV 196
                          90       100
                  ....*....|....*....|
gi 226342982  885 DVWSFGILLWEIFTlGGTPY 904
Cdd:cd05593   197 DWWGLGVVMYEMMC-GRLPF 215
STKc_PASK cd14004
Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs ...
809-949 7.69e-06

Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PASK (or PASKIN) is a nutrient and energy sensor and thus, plays an important role in maintaining cellular energy homeostasis. It coordinates the utilization of glucose in response to metabolic demand. It contains an N-terminal PAS domain which directly interacts and inhibits a C-terminal catalytic kinase domain. The PAS domain serves as a sensory module for different environmental signals such as light, redox state, and various metabolites. Binding of ligands to the PAS domain causes structural changes which leads to kinase activation and the phosphorylation of substrates to trigger the appropriate cellular response. The PASK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270906 [Multi-domain]  Cd Length: 256  Bit Score: 48.54  E-value: 7.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLArdimrdsNYISKG--STFL-PLKWMAPESIFNSLYT-TLS 884
Cdd:cd14004   117 QVADAVKHLHDQGIVHRDIKDENVILDGNGTIKLIDFGSA-------AYIKSGpfDTFVgTIDYAAPEVLRGNPYGgKEQ 189
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  885 DVWSFGILLWEIFtlggtpYPELPmndqFYN---AIKRGYRMaqPAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd14004   190 DIWALGVLLYTLV------FKENP----FYNieeILEADLRI--PYAVSEDLIDLISRMLNRDVGDRP 245
STKc_JNK cd07850
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; STKs catalyze the ...
798-896 7.87e-06

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. They are also essential regulators of physiological and pathological processes and are involved in the pathogenesis of several diseases such as diabetes, atherosclerosis, stroke, Parkinson's and Alzheimer's. Vetebrates harbor three different JNK genes (Jnk1, Jnk2, and Jnk3) that are alternatively spliced to produce at least 10 isoforms. JNKs are specifically activated by the MAPK kinases MKK4 and MKK7, which are in turn activated by upstream MAPK kinase kinases as a result of different stimuli including stresses such as ultraviolet (UV) irradiation, hyperosmolarity, heat shock, or cytokines. JNKs activate a large number of different substrates based on specific stimulus, cell type, and cellular condition, and may be implicated in seemingly contradictory functions. The JNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270840 [Multi-domain]  Cd Length: 337  Bit Score: 49.33  E-value: 7.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  798 LSYtdlvgFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdimrdsnyiSKGSTFLPLKWM------A 871
Cdd:cd07850   104 MSY-----LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR---------TAGTSFMMTPYVvtryyrA 169
                          90       100
                  ....*....|....*....|....*
gi 226342982  872 PESIFNSLYTTLSDVWSFGILLWEI 896
Cdd:cd07850   170 PEVILGMGYKENVDIWSVGCIMGEM 194
STKc_SnRK2 cd14662
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
806-932 7.99e-06

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK2 is represented in this cd. SnRK2s are involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development. The SnRK2s subfamily is in turn classed into three subgroups, all 3 of which are represented in this CD. Group 1 comprises kinases not activated by ABA, group 2 - kinases not activated or activated very weakly by ABA (depending on plant species), and group 3 - kinases strongly activated by ABA. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271132 [Multi-domain]  Cd Length: 257  Bit Score: 48.61  E-value: 7.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLI--CEGKLVKICDFGLARDIMRDSNyisKGSTFLPLKWMAPESIFNSLYT-T 882
Cdd:cd14662   101 FFQQLISGVSYCHSMQICHRDLKLENTLLdgSPAPRLKICDFGYSKSSVLHSQ---PKSTVGTPAYIAPEVLSRKEYDgK 177
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 226342982  883 LSDVWSFGILLWeIFTLGGTPY--PELPMNdqFYNAIKR----GYRMAQPAHASDE 932
Cdd:cd14662   178 VADVWSCGVTLY-VMLVGAYPFedPDDPKN--FRKTIQRimsvQYKIPDYVRVSQD 230
STKc_PLK2 cd14188
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the ...
785-949 8.04e-06

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK2, also called Snk (serum-inducible kinase), functions in G1 progression, S-phase arrest, and centriole duplication. Its gene is responsive to both growth factors and cellular stress, is a transcriptional target of p53, and activates a G2-M checkpoint. The PLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271090 [Multi-domain]  Cd Length: 255  Bit Score: 48.85  E-value: 8.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  785 RTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLA----------RDIMRD 854
Cdd:cd14188    85 RRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINENMELKVGDFGLAarleplehrrRTICGT 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  855 SNYISkgstflplkwmaPESIFNSLYTTLSDVWSFGILLWEIFtLGGTPYPELPMNDQfYNAIKRGyRMAQPAHASDEIY 934
Cdd:cd14188   165 PNYLS------------PEVLNKQGHGCESDIWALGCVMYTML-LGRPPFETTNLKET-YRCIREA-RYSLPSSLLAPAK 229
                         170
                  ....*....|....*
gi 226342982  935 EIMQKCWEEKFETRP 949
Cdd:cd14188   230 HLIASMLSKNPEDRP 244
STKc_DCKL1 cd14183
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called ...
802-904 8.12e-06

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL1 (or DCAMKL1) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL1 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL1 interacts with tubulin, glucocorticoid receptor, dynein, JIP1/2, caspases (3 and 8), and calpain, among others. It plays roles in neurogenesis, neuronal migration, retrograde transport, and neuronal apoptosis. The DCKL1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271085 [Multi-domain]  Cd Length: 268  Bit Score: 48.84  E-value: 8.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  802 DLVGFSYQVANGMDFLASKNCVHRDLAARNVLICE----GKLVKICDFGLArDIMRDSNYISKGSTflplKWMAPESIFN 877
Cdd:cd14183   105 DASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEhqdgSKSLKLGDFGLA-TVVDGPLYTVCGTP----TYVAPEIIAE 179
                          90       100
                  ....*....|....*....|....*..
gi 226342982  878 SLYTTLSDVWSFGILLWeIFTLGGTPY 904
Cdd:cd14183   180 TGYGLKVDIWAAGVITY-ILLCGFPPF 205
STKc_CaMKI_gamma cd14166
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
809-953 8.25e-06

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271068 [Multi-domain]  Cd Length: 285  Bit Score: 48.84  E-value: 8.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLIC---EGKLVKICDFGLARdiMRDSNYISKGSTfLPlKWMAPESIFNSLYTTLSD 885
Cdd:cd14166   108 QVLSAVKYLHENGIVHRDLKPENLLYLtpdENSKIMITDFGLSK--MEQNGIMSTACG-TP-GYVAPEVLAQKPYSKAVD 183
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  886 VWSFGILLWeIFTLGGTPYPElPMNDQFYNAIKRG-YRMAQP------AHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14166   184 CWSIGVITY-ILLCGYPPFYE-ETESRLFEKIKEGyYEFESPfwddisESAKDFIRHLLEKNPSKRYTCEKALSH 256
pk1 PHA03390
serine/threonine-protein kinase 1; Provisional
808-904 8.93e-06

serine/threonine-protein kinase 1; Provisional


Pssm-ID: 223069 [Multi-domain]  Cd Length: 267  Bit Score: 48.70  E-value: 8.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKL-VKICDFGLARDIMRDSNYisKGStflpLKWMAPESIFNSLYTTLSDV 886
Cdd:PHA03390  116 RQLVEALNDLHKHNIIHNDIKLENVLYDRAKDrIYLCDYGLCKIIGTPSCY--DGT----LDYFSPEKIKGHNYDVSFDW 189
                          90
                  ....*....|....*...
gi 226342982  887 WSFGILLWEIFTlGGTPY 904
Cdd:PHA03390  190 WAVGVLTYELLT-GKHPF 206
STKc_JNK3 cd07874
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 3; STKs catalyze the ...
808-896 9.91e-06

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK3 is expressed primarily in the brain, and to a lesser extent in the heart and testis. Mice deficient in JNK3 are protected against kainic acid-induced seizures, stroke, sciatic axotomy neural death, and neuronal death due to NGF deprivation, oxidative stress, or exposure to beta-amyloid peptide. This suggests that JNK3 may play roles in the pathogenesis of these diseases. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143379 [Multi-domain]  Cd Length: 355  Bit Score: 48.93  E-value: 9.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdimrdsnyiSKGSTFLPLKWM------APESIFNSLYT 881
Cdd:cd07874   126 YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR---------TAGTSFMMTPYVvtryyrAPEVILGMGYK 196
                          90
                  ....*....|....*
gi 226342982  882 TLSDVWSFGILLWEI 896
Cdd:cd07874   197 ENVDIWSVGCIMGEM 211
PK_Unc-89_rpt1 cd14109
Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein ...
801-904 1.15e-05

Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. The nematode Unc-89 gene, through alternative promoter use and splicing, encodes at least six major isoforms (Unc-89A to Unc-89F) of giant muscle proteins that are homologs for the vetebrate obscurin. In flies, five isoforms of Unc-89 have been detected: four in the muscles of adult flies (two in the indirect flight muscle and two in other muscles) and another isoform in the larva. Unc-89 in nematodes is required for normal muscle cell architecture. In flies, it is necessary for the development of a symmetrical sarcomere in the flight muscles. Unc-89 proteins contain several adhesion and signaling domains including multiple copies of the immunoglobulin (Ig) domain, as well as fibronectin type III (FN3), SH3, RhoGEF, and PH domains. The nematode Unc-89 isoforms D, C, D, and F contain two kinase domain with B and F having two complete kinase domains while the first repeat of C and D are partial domains. Homology modeling suggests that the first kinase repeat of Unc-89 may be catalytically inactive, a pseudokinase, while the second kinase repeat may be active. The pseudokinase domain may function as a regulatory domain or a protein interaction domain. The Unc-89 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271011 [Multi-domain]  Cd Length: 255  Bit Score: 48.28  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  801 TDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLvKICDFGLARDIMRDSNY-ISKGSTflplKWMAPEsIFNSL 879
Cdd:cd14109    99 RQVAVFVRQLLLALKHMHDLGIAHLDLRPEDILLQDDKL-KLADFGQSRRLLRGKLTtLIYGSP----EFVSPE-IVNSY 172
                          90       100
                  ....*....|....*....|....*.
gi 226342982  880 YTTLS-DVWSFGILLWEIFTlGGTPY 904
Cdd:cd14109   173 PVTLAtDMWSVGVLTYVLLG-GISPF 197
STKc_PKB_alpha cd05594
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1); ...
806-904 1.18e-05

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-alpha is predominantly expressed in endothelial cells. It is critical for the regulation of angiogenesis and the maintenance of vascular integrity. It also plays a role in adipocyte differentiation. Mice deficient in PKB-alpha exhibit perinatal morbidity, growth retardation, reduction in body weight accompanied by reduced sizes of multiple organs, and enhanced apoptosis in some cell types. PKB-alpha activity has been reported to be frequently elevated in breast and prostate cancers. In some cancer cells, PKB-alpha may act as a suppressor of metastasis. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. The PKB-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270746 [Multi-domain]  Cd Length: 356  Bit Score: 48.87  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFL-ASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYIskgSTFLPL-KWMAPESIFNSLYTTL 883
Cdd:cd05594   130 YGAEIVSALDYLhSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM---KTFCGTpEYLAPEVLEDNDYGRA 206
                          90       100
                  ....*....|....*....|.
gi 226342982  884 SDVWSFGILLWEIFTlGGTPY 904
Cdd:cd05594   207 VDWWGLGVVMYEMMC-GRLPF 226
STKc_Sck1_like cd05586
Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine ...
814-920 1.19e-05

Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Sck1 and similar fungal proteins. Sck1 plays a role in trehalase activation triggered by glucose and a nitrogen source. Trehalase catalyzes the cleavage of the disaccharide trehalose to glucose. Trehalose, as a carbohydrate reserve and stress metabolite, plays an important role in the response of yeast to environmental changes. The Sck1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270738 [Multi-domain]  Cd Length: 330  Bit Score: 48.72  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  814 MDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISK--GSTflplKWMAPESIFNSL-YTTLSDVWSFG 890
Cdd:cd05586   109 LEHLHKNDIVYRDLKPENILLDANGHIALCDFGLSKADLTDNKTTNTfcGTT----EYLAPEVLLDEKgYTKMVDFWSLG 184
                          90       100       110
                  ....*....|....*....|....*....|
gi 226342982  891 ILLWEIfTLGGTPYpELPMNDQFYNAIKRG 920
Cdd:cd05586   185 VLVFEM-CCGWSPF-YAEDTQQMYRNIAFG 212
STKc_RCK1-like cd14096
Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
809-903 1.21e-05

Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal STKs including Saccharomyces cerevisiae RCK1 and RCK2, Schizosaccharomyces pombe Sty1-regulated kinase 1 (Srk1), and similar proteins. RCK1, RCK2 (or Rck2p), and Srk1 are MAPK-activated protein kinases. RCK1 and RCK2 are involved in oxidative and metal stress resistance in budding yeast. RCK2 also regulates rapamycin sensitivity in both S. cerevisiae and Candida albicans. Srk1 is activated by Sty1/Spc1 and is involved in negatively regulating cell cycle progression by inhibiting Cdc25. The RCK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270998 [Multi-domain]  Cd Length: 295  Bit Score: 48.59  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVL----------------------ICEGK-----------LVKICDFGLARdIMRDS 855
Cdd:cd14096   114 QVASAVKYLHEIGVVHRDIKPENLLfepipfipsivklrkadddetkVDEGEfipgvggggigIVKLADFGLSK-QVWDS 192
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 226342982  856 NYISKGSTFlplKWMAPESIFNSLYTTLSDVWSFGILLWEIftLGGTP 903
Cdd:cd14096   193 NTKTPCGTV---GYTAPEVVKDERYSKKVDMWALGCVLYTL--LCGFP 235
STKc_PFTAIRE1 cd07869
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer ...
806-913 1.27e-05

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-1 is widely expressed except in the spleen and thymus. It is highly expressed in the brain, heart, pancreas, testis, and ovary, and is localized in the cytoplasm. It is regulated by cyclin D3 and is inhibited by the p21 cell cycle inhibitor. It has also been shown to interact with the membrane-associated cyclin Y, which recruits the protein to the plasma membrane. PFTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143374 [Multi-domain]  Cd Length: 303  Bit Score: 48.54  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLplkWMAPESIF--NSLYTTL 883
Cdd:cd07869   108 FLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTL---WYRPPDVLlgSTEYSTC 184
                          90       100       110
                  ....*....|....*....|....*....|.
gi 226342982  884 SDVWSFGILLWEIFTlGGTPYPELP-MNDQF 913
Cdd:cd07869   185 LDMWGVGCIFVEMIQ-GVAAFPGMKdIQDQL 214
STKc_GRK2 cd14223
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2; STKs ...
797-912 1.37e-05

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK2, also called beta-adrenergic receptor kinase (beta-ARK) or beta-ARK1, is important in regulating several cardiac receptor responses. It plays a role in cardiac development and in hypertension. Deletion of GRK2 in mice results in embryonic lethality, caused by hypoplasia of the ventricular myocardium. GRK2 also plays important roles in the liver (as a regulator of portal blood pressure), in immune cells, and in the nervous system. Altered GRK2 expression has been reported in several disorders including major depression, schizophrenia, bipolar disorder, and Parkinsonism. GRK2 contains an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. TheGRK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271125 [Multi-domain]  Cd Length: 321  Bit Score: 48.51  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  797 VLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTflplKWMAPESIF 876
Cdd:cd14223    99 VFSEAEMRFYAAEIILGLEHMHSRFVVYRDLKPANILLDEFGHVRISDLGLACDFSKKKPHASVGTH----GYMAPEVLQ 174
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 226342982  877 NSL-YTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQ 912
Cdd:cd14223   175 KGVaYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDK 210
STKc_SIK cd14071
Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the ...
604-894 1.37e-05

Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SIKs are part of a complex network that regulates Na,K-ATPase to maintain sodium homeostasis and blood pressure. Vertebrates contain three forms of SIKs (SIK1-3) from three distinct genes, which display tissue-specific effects. SIK1, also called SNF1LK, controls steroidogenic enzyme production in adrenocortical cells. In the brain, both SIK1 and SIK2 regulate energy metabolism. SIK2, also called QIK or SNF1LK2, is involved in the regulation of gluconeogenesis in the liver and lipogenesis in adipose tissues, where it phosphorylates the insulin receptor substrate-1. In the liver, SIK3 (also called QSK) regulates cholesterol and bile acid metabolism. In addition, SIK2 plays an important role in the initiation of mitosis and regulates the localization of C-Nap1, a centrosome linker protein. The SIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270973 [Multi-domain]  Cd Length: 253  Bit Score: 47.77  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEATahglsHSQATMKVAVKML-KSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGPIYIITE 682
Cdd:cd14071     6 RTIGKGNFAVVKLAR-----HRITKTEVAIKIIdKSQLDEENLKKIYREVQIMKMLN-HPHIIKLYQVMETKDMLYLVTE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  683 YCRYGDLVDYLHRNKHtflqrhsnkhcppsaelysnalpvgfslpshlnltgesdggymdMSKDESidyvpmldmkgdik 762
Cdd:cd14071    80 YASNGEIFDYLAQHGR--------------------------------------------MSEKEA-------------- 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  763 yadiespsymapydnyvpsapERTYratlindspvlsytdlvgfsYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKI 842
Cdd:cd14071   102 ---------------------RKKF--------------------WQILSAVEYCHKRHIVHRDLKAENLLLDANMNIKI 140
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  843 CDFGLardimrdSNYISKGStflPLK-------WMAPESIFNSLYTTLS-DVWSFGILLW 894
Cdd:cd14071   141 ADFGF-------SNFFKPGE---LLKtwcgsppYAAPEVFEGKEYEGPQlDIWSLGVVLY 190
STKc_SNRK cd14074
Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the ...
602-932 1.47e-05

Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SNRK is a kinase highly expressed in testis and brain that is found inactive in cells that lack the LKB1 tumour suppressor protein kinase. The regulatory subunits STRAD and MO25 are required for LKB1 to activate SNRK. The SNRK mRNA is increased 3-fold when granule neurons are cultured in low potassium, and may thus play a role in the survival responses in these cells. In some vertebrates, a second SNRK gene (snrkb or snrk-1) has been sequenced and/or identified. Snrk-1 is expressed specifically in embryonic zebrafish vasculature; it plays an essential role in angioblast differentiation, maintenance, and migration. The SNRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270976 [Multi-domain]  Cd Length: 258  Bit Score: 47.79  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  602 LGRTLGSGAFGqVVEATAHGLSHSqatmKVAVKMLKSTARSSEKQA-LMSELKIMShLGPHLNVVNLLGACTKGGPIYII 680
Cdd:cd14074     7 LEETLGRGHFA-VVKLARHVFTGE----KVAVKVIDKTKLDDVSKAhLFQEVRCMK-LVQHPNVVRLYEVIDTQTKLYLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  681 TEYCRYGDLVDYlhrnkhtfLQRHSNKHCPPSAELYsnalpvgfslpshlnltgesdggymdmskdesidyvpmldmkgd 760
Cdd:cd14074    81 LELGDGGDMYDY--------IMKHENGLNEDLARKY-------------------------------------------- 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  761 ikyadiespsymapydnyvpsapertYRatlindspvlsytdlvgfsyQVANGMDFLASKNCVHRDLAARNVLICEG-KL 839
Cdd:cd14074   109 --------------------------FR--------------------QIVSAISYCHKLHVVHRDLKPENVVFFEKqGL 142
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  840 VKICDFGLARDIMRDSNY-ISKGStflpLKWMAPESIFNSLYTTLS-DVWSFGILLWeIFTLGGTPYPELPMNDQFYNAI 917
Cdd:cd14074   143 VKLTDFGFSNKFQPGEKLeTSCGS----LAYSAPEILLGDEYDAPAvDIWSLGVILY-MLVCGQPPFQEANDSETLTMIM 217
                         330
                  ....*....|....*
gi 226342982  918 KRGYRMaqPAHASDE 932
Cdd:cd14074   218 DCKYTV--PAHVSPE 230
STKc_TLK cd13990
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the ...
809-949 1.74e-05

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. They phosphorylate and regulate Anti-silencing function 1 protein (Asf1), a histone H3/H4 chaperone that helps facilitate the assembly of chromatin following DNA replication during S phase. TLKs also phosphorylate the H3 histone tail and are essential in transcription. Vertebrates contain two subfamily members, TLK1 and TLK2. The TLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270892 [Multi-domain]  Cd Length: 279  Bit Score: 47.70  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKN--CVHRDLAARNVLICEGKL---VKICDFGLARdIMRDSNYISKG----STFLPLKWMAPESIF--- 876
Cdd:cd13990   113 QVVSALKYLNEIKppIIHYDLKPGNILLHSGNVsgeIKITDFGLSK-IMDDESYNSDGmeltSQGAGTYWYLPPECFvvg 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  877 --NSLYTTLSDVWSFGILLWEI------FTLGGTPYPELpmndqFYNAIKRGYRMAQPA--HASDEIYEIMQKCWEEKFE 946
Cdd:cd13990   192 ktPPKISSKVDVWSVGVIFYQMlygrkpFGHNQSQEAIL-----EENTILKATEVEFPSkpVVSSEAKDFIRRCLTYRKE 266

                  ...
gi 226342982  947 TRP 949
Cdd:cd13990   267 DRP 269
STKc_EIF2AK4_GCN2_rpt2 cd14046
Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation ...
809-895 1.82e-05

Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GCN2 (or EIF2AK4) is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. Its kinase domain is activated via conformational changes as a result of the binding of uncharged tRNA to the HisRS-like domain. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270948 [Multi-domain]  Cd Length: 278  Bit Score: 47.75  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISK--------------------GSTFlplk 868
Cdd:cd14046   112 QILEGLAYIHSQGIIHRDLKPVNIFLDSNGNVKIGDFGLATSNKLNVELATQdinkstsaalgssgdltgnvGTAL---- 187
                          90       100
                  ....*....|....*....|....*....
gi 226342982  869 WMAPE--SIFNSLYTTLSDVWSFGILLWE 895
Cdd:cd14046   188 YVAPEvqSGTKSTYNEKVDMYSLGIIFFE 216
STKc_HIPK3 cd14229
Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3; ...
809-912 1.89e-05

Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HIPK3 is a Fas-interacting protein that induces FADD (Fas-associated death domain) phosphorylation and mediates FasL-induced JNK activation. Overexpression of HIPK3 does not affect cell death, however its expression in prostate cancer cells contributes to increased resistance to Fas receptor-mediated apoptosis. HIPK3 also plays a role in regulating steroidogenic gene expression. In response to cAMP, HIPK3 activates the phosphorylation of JNK and c-Jun, leading to increased activity of the transcription factor SF-1 (Steroidogenic factor 1), a key regulator for steroid biosynthesis in the gonad and adrenal gland. HIPKs, originally identified by their ability to bind homeobox factors, are nuclear proteins containing catalytic kinase and homeobox-interacting domains as well as a PEST region overlapping with the speckle-retention signal (SRS). The HIPK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271131 [Multi-domain]  Cd Length: 330  Bit Score: 48.10  E-value: 1.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLIC----EGKLVKICDFGLArdimrdsNYISKG--STFLPLKWM-APESIFNSLYT 881
Cdd:cd14229   110 QVATALKKLKSLGLIHADLKPENIMLVdpvrQPYRVKVIDFGSA-------SHVSKTvcSTYLQSRYYrAPEIILGLPFC 182
                          90       100       110
                  ....*....|....*....|....*....|.
gi 226342982  882 TLSDVWSFGILLWEIFtLGGTPYPELPMNDQ 912
Cdd:cd14229   183 EAIDMWSLGCVIAELF-LGWPLYPGALEYDQ 212
IgI_1_MuSK cd20970
agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of ...
213-309 2.24e-05

agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains; The members here are composed of the first immunoglobulin-like domains (Ig1) of the Muscle-specific kinase (MuSK). MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409562 [Multi-domain]  Cd Length: 92  Bit Score: 44.04  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  213 INVSVNAVQTVVRQGESITIRCIVMGNDVVNFQWtypRMKSGRLVEPVTDYLFgvpSRIGSILHIPTAELSDSGTYTCNV 292
Cdd:cd20970     3 ISTPQPSFTVTAREGENATFMCRAEGSPEPEISW---TRNGNLIIEFNTRYIV---RENGTTLTIRNIRRSDMGIYLCIA 76
                          90
                  ....*....|....*..
gi 226342982  293 SVSVNDhGDEKAINISV 309
Cdd:cd20970    77 SNGVPG-SVEKRITLQV 92
STKc_beta_ARK cd05606
Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase; STKs ...
797-904 2.62e-05

Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The beta-ARK group is composed of GRK2, GRK3, and similar proteins. GRK2 and GRK3 are both widely expressed in many tissues, although GRK2 is present at higher levels. They contain an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRK2 (also called beta-ARK or beta-ARK1) is important in regulating several cardiac receptor responses. It plays a role in cardiac development and in hypertension. Deletion of GRK2 in mice results in embryonic lethality, caused by hypoplasia of the ventricular myocardium. GRK2 also plays important roles in the liver (as a regulator of portal blood pressure), in immune cells, and in the nervous system. Altered GRK2 expression has been reported in several disorders including major depression, schizophrenia, bipolar disorder, and Parkinsonism. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The beta-ARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270757 [Multi-domain]  Cd Length: 279  Bit Score: 47.43  E-value: 2.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  797 VLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTflplKWMAPESIF 876
Cdd:cd05606    94 VFSEAEMRFYAAEVILGLEHMHNRFIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH----GYMAPEVLQ 169
                          90       100
                  ....*....|....*....|....*....
gi 226342982  877 NSL-YTTLSDVWSFGILLWEIFTlGGTPY 904
Cdd:cd05606   170 KGVaYDSSADWFSLGCMLYKLLK-GHSPF 197
STKc_MSK1_N cd05613
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
806-904 2.62e-05

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK1 plays a role in the regulation of translational control and transcriptional activation. It phosphorylates the transcription factors, CREB and NFkB. It also phosphorylates the nucleosomal proteins H3 and HMG-14. Increased phosphorylation of MSK1 is associated with the development of cerebral ischemic/hypoxic preconditioning. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270764 [Multi-domain]  Cd Length: 290  Bit Score: 47.30  E-value: 2.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNyiSKGSTFL-PLKWMAPESIF--NSLYTT 882
Cdd:cd05613   110 YIGEIVLALEHLHKLGIIYRDIKLENILLDSSGHVVLTDFGLSKEFLLDEN--ERAYSFCgTIEYMAPEIVRggDSGHDK 187
                          90       100
                  ....*....|....*....|..
gi 226342982  883 LSDVWSFGILLWEIFTlGGTPY 904
Cdd:cd05613   188 AVDWWSLGVLMYELLT-GASPF 208
PK_STRAD cd08216
Pseudokinase domain of STE20-related kinase adapter protein; The pseudokinase domain shows ...
808-908 2.78e-05

Pseudokinase domain of STE20-related kinase adapter protein; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. LKB1 is a tumor suppressor linked to the rare inherited disease, Peutz-Jeghers syndrome, which is characterized by a predisposition to benign polyps and hyperpigmentation of the buccal mucosa. There are two forms of STRAD, alpha and beta, that complex with LKB1 and MO25. The structure of STRAD-alpha is available and shows that this protein binds ATP, has an ordered activation loop, and adopts a closed conformation typical of fully active protein kinases. It does not possess activity due to nonconservative substitutions of essential catalytic residues. ATP binding enhances the affinity of STRAD for MO25. The conformation of STRAD-alpha stabilized through ATP and MO25 may be needed to activate LKB1. The STRAD subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270856 [Multi-domain]  Cd Length: 315  Bit Score: 47.29  E-value: 2.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYIS------KGSTFLpLKWMAPESIFNSL-- 879
Cdd:cd08216   108 RDVLNALEYIHSKGYIHRSVKASHILISGDGKVVLSGLRYAYSMVKHGKRQRvvhdfpKSSEKN-LPWLSPEVLQQNLlg 186
                          90       100
                  ....*....|....*....|....*....
gi 226342982  880 YTTLSDVWSFGILLWEIFTlGGTPYPELP 908
Cdd:cd08216   187 YNEKSDIYSVGITACELAN-GVVPFSDMP 214
STKc_p70S6K cd05584
Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs ...
817-904 2.86e-05

Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p70S6K (or S6K) contains only one catalytic kinase domain, unlike p90 ribosomal S6 kinases (RSKs). It acts as a downstream effector of the STK mTOR (mammalian Target of Rapamycin) and plays a role in the regulation of the translation machinery during protein synthesis. p70S6K also plays a pivotal role in regulating cell size and glucose homeostasis. Its targets include S6, the translation initiation factor eIF3, and the insulin receptor substrate IRS-1, among others. Mammals contain two isoforms of p70S6K, named S6K1 and S6K2 (or S6K-beta). The p70S6K subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270736 [Multi-domain]  Cd Length: 323  Bit Score: 47.40  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  817 LASKNCVHRDLAARNVLI-CEGKlVKICDFGLARDIMRDSnyiSKGSTFL-PLKWMAPESIFNSLYTTLSDVWSFGILLW 894
Cdd:cd05584   116 LHSLGIIYRDLKPENILLdAQGH-VKLTDFGLCKESIHDG---TVTHTFCgTIEYMAPEILTRSGHGKAVDWWSLGALMY 191
                          90
                  ....*....|
gi 226342982  895 EIFTlGGTPY 904
Cdd:cd05584   192 DMLT-GAPPF 200
STKc_PAK4 cd06657
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the ...
810-908 2.98e-05

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK4 regulates cell morphology and cytoskeletal organization. It is essential for embryonic viability and proper neural development. Mice lacking PAK4 die due to defects in the fetal heart. In addition, their spinal cord motor neurons showed failure to differentiate and migrate. PAK4 also plays a role in cell survival and tumorigenesis. It is overexpressed in many primary tumors including colon, esophageal, and mammary tumors. PAK4 has also been implicated in viral and bacterial infection pathways. PAK4 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132988 [Multi-domain]  Cd Length: 292  Bit Score: 47.32  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFG----LARDIMRDSNYIskGSTFlplkWMAPESIFNSLYTTLSD 885
Cdd:cd06657   125 VLKALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGfcaqVSKEVPRRKSLV--GTPY----WMAPELISRLPYGPEVD 198
                          90       100
                  ....*....|....*....|...
gi 226342982  886 VWSFGILLWEIFTlGGTPYPELP 908
Cdd:cd06657   199 IWSLGIMVIEMVD-GEPPYFNEP 220
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
33-103 3.15e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 43.32  E-value: 3.15e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226342982    33 VITPPGPEFVLNISSTFVLTCSGSAP----VMWEQMSQVPW-QEAAMNQDGTFSSVLTLTNVTGGDTGEYFCVYNN 103
Cdd:pfam13927    3 VITVSPSSVTVREGETVTLTCEATGSppptITWYKNGEPISsGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVASN 78
STKc_PIM2 cd14101
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
806-953 3.58e-05

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are three PIM2 isoforms resulting from alternative translation initiation sites. PIM2 is highly expressed in leukemia and lymphomas and has been shown to promote the survival and proliferation of tumor cells. The PIM2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271003 [Multi-domain]  Cd Length: 257  Bit Score: 46.77  E-value: 3.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLI-CEGKLVKICDFGlARDIMRDSNYISKGSTFLplkWMAPESIFNSLYTTL- 883
Cdd:cd14101   113 FFKQVVEAVQHCHSKGVVHRDIKDENILVdLRTGDIKLIDFG-SGATLKDSMYTDFDGTRV---YSPPEWILYHQYHALp 188
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  884 SDVWSFGILLWEIfTLGGTPYPElpmnDQFYNAIKRGYrmaqPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14101   189 ATVWSLGILLYDM-VCGDIPFER----DTDILKAKPSF----NKRVSNDCRSLIRSCLAYNPSDRPSLEQ 249
STKc_JNK2 cd07876
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2; STKs catalyze the ...
808-896 3.62e-05

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK2 is expressed in every cell and tissue type. It is specifically translocated to the mitochondria during dopaminergic cell death. Specific substrates include the microtubule-associated proteins DCX and Tau, as well as TIF-IA which is involved in ribosomal RNA synthesis regulation. Mice deficient in Jnk2 show protection against arthritis, type 1 diabetes, atherosclerosis, abdominal aortic aneurysm, cardiac cell death, TNF-induced liver damage, and tumor growth, indicating that JNK2 may play roles in the pathogenesis of these diseases. Initially it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143381 [Multi-domain]  Cd Length: 359  Bit Score: 47.33  E-value: 3.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  808 YQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARdiMRDSNYISKgSTFLPLKWMAPESIFNSLYTTLSDVW 887
Cdd:cd07876   130 YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR--TACTNFMMT-PYVVTRYYRAPEVILGMGYKENVDIW 206

                  ....*....
gi 226342982  888 SFGILLWEI 896
Cdd:cd07876   207 SVGCIMGEL 215
STKc_SGK1 cd05602
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
806-903 3.88e-05

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK1 is ubiquitously expressed and is under transcriptional control of numerous stimuli including cell stress (cell shrinkage), serum, hormones (gluco- and mineralocorticoids), gonadotropins, growth factors, interleukin-6, and other cytokines. It plays roles in sodium retention and potassium elimination in the kidney, nutrient transport, salt sensitivity, memory consolidation, and cardiac repolarization. A common SGK1 variant is associated with increased blood pressure and body weight. SGK1 may also contribute to tumor growth, neurodegeneration, fibrosing disease, and ischemia. The SGK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270753 [Multi-domain]  Cd Length: 339  Bit Score: 47.32  E-value: 3.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSnyiSKGSTFLPL-KWMAPESIFNSLYTTLS 884
Cdd:cd05602   113 YAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEPN---GTTSTFCGTpEYLAPEVLHKQPYDRTV 189
                          90
                  ....*....|....*....
gi 226342982  885 DVWSFGILLWEIftLGGTP 903
Cdd:cd05602   190 DWWCLGAVLYEM--LYGLP 206
PLN00009 PLN00009
cyclin-dependent kinase A; Provisional
806-906 3.93e-05

cyclin-dependent kinase A; Provisional


Pssm-ID: 177649 [Multi-domain]  Cd Length: 294  Bit Score: 46.73  E-value: 3.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGK-LVKICDFGLARDI---MRDSNYiskgsTFLPLKWMAPESIFNSL-Y 880
Cdd:PLN00009  107 YLYQILRGIAYCHSHRVLHRDLKPQNLLIDRRTnALKLADFGLARAFgipVRTFTH-----EVVTLWYRAPEILLGSRhY 181
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 226342982  881 TTLSDVWSFGIL-------------------LWEIFTLGGTPYPE 906
Cdd:PLN00009  182 STPVDIWSVGCIfaemvnqkplfpgdseideLFKIFRILGTPNEE 226
STKc_TSSK3-like cd14163
Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs ...
602-702 3.96e-05

Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. Its mRNA levels is low at birth, increases at puberty, and remains high throughout adulthood. The TSSK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271065 [Multi-domain]  Cd Length: 257  Bit Score: 46.52  E-value: 3.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  602 LGRTLGSGAFGQVVEATAHglSHSQatmKVAVKMLKSTARSSE--KQALMSELKIMSHLGpHLNVVNLLGAC-TKGGPIY 678
Cdd:cd14163     4 LGKTIGEGTYSKVKEAFSK--KHQR---KVAIKIIDKSGGPEEfiQRFLPRELQIVERLD-HKNIIHVYEMLeSADGKIY 77
                          90       100       110
                  ....*....|....*....|....*....|..
gi 226342982  679 IITEYCRYGDLVDYL--------HRNKHTFLQ 702
Cdd:cd14163    78 LVMELAEDGDVFDCVlhggplpeHRAKALFRQ 109
STKc_CDK8 cd07868
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8; STKs ...
787-943 4.21e-05

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK8 can act as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II (RNAP II)-dependent transcription. CDK8 phosphorylates cyclin H, a subunit of the general transcription factor TFIIH, which results in the inhibition of TFIIH-dependent phosphorylation of the C-terminal domain of RNAP II, facilitating the inhibition of transcription. It has also been shown to promote transcription by a mechanism that is likely to involve RNAP II phosphorylation. CDK8 also functions as a stimulus-specific positive coregulator of p53 transcriptional responses. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK8 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270851 [Multi-domain]  Cd Length: 333  Bit Score: 46.97  E-value: 4.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  787 YRATLINDSPVLSYTDLV-GFSYQVANGMDFLASKNCVHRDLAARNVLIC----EGKLVKICDFGLARDIMRDSNYISKG 861
Cdd:cd07868   109 HRASKANKKPVQLPRGMVkSLLYQILDGIHYLHANWVLHRDLKPANILVMgegpERGRVKIADMGFARLFNSPLKPLADL 188
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  862 STFLPLKWM-APESIFNSL-YTTLSDVWSFGILLWEIFTlggtpypelpmNDQFYNAIKRGYRMAQPAHAS--DEIYEIM 937
Cdd:cd07868   189 DPVVVTFWYrAPELLLGARhYTKAIDIWAIGCIFAELLT-----------SEPIFHCRQEDIKTSNPYHHDqlDRIFNVM 257
                         170
                  ....*....|
gi 226342982  938 ----QKCWEE 943
Cdd:cd07868   258 gfpaDKDWED 267
STKc_CAMKK cd14118
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; ...
813-904 4.49e-05

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271020 [Multi-domain]  Cd Length: 275  Bit Score: 46.58  E-value: 4.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  813 GMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISK--GSTflplKWMAPESIF---NSLYTTLSDVW 887
Cdd:cd14118   127 GIEYLHYQKIIHRDIKPSNLLLGDDGHVKIADFGVSNEFEGDDALLSStaGTP----AFMAPEALSesrKKFSGKALDIW 202
                          90
                  ....*....|....*..
gi 226342982  888 SFGILLWeIFTLGGTPY 904
Cdd:cd14118   203 AMGVTLY-CFVFGRCPF 218
STKc_MSK_C cd14092
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
809-894 4.51e-05

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270994 [Multi-domain]  Cd Length: 311  Bit Score: 46.91  E-value: 4.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVL---ICEGKLVKICDFGLARdiMRDSNYISKGSTFlPLKWMAPESIFNSL----YT 881
Cdd:cd14092   107 QLVSAVSFMHSKGVVHRDLKPENLLftdEDDDAEIKIVDFGFAR--LKPENQPLKTPCF-TLPYAAPEVLKQALstqgYD 183
                          90
                  ....*....|...
gi 226342982  882 TLSDVWSFGILLW 894
Cdd:cd14092   184 ESCDLWSLGVILY 196
STKc_TGFbR1_ACVR1b_ACVR1c cd14143
Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I ...
824-948 4.86e-05

Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TGFbR1, also called Activin receptor-Like Kinase 5 (ALK5), functions as a receptor for TGFbeta and phoshorylates SMAD2/3. TGFbeta proteins are cytokines that regulate cell growth, differentiation, and survival, and are critical in the development and progression of many human cancers. Mutations in TGFbR1 (and TGFbR2) can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. ACVR1b (also called ALK4) and ACVR1c (also called ALK7) act as receptors for activin A and B, respectively. TGFbR1, ACVR1b, and ACVR1c belong to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like TGFbR1, ACVR1b, and ACVR1c, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The TGFbR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271045 [Multi-domain]  Cd Length: 288  Bit Score: 46.67  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  824 HRDLAARNVLICEGKLVKICDFGLA--RDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTL------SDVWSFGILLWE 895
Cdd:cd14143   123 HRDLKSKNILVKKNGTCCIADLGLAvrHDSATDTIDIAPNHRVGTKRYMAPEVLDDTINMKHfesfkrADIYALGLVFWE 202
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226342982  896 IF---TLGGT------PYPELPMNDQFYNAIKR-----GYRMAQPAH-ASDEIYE----IMQKCWEEKFETR 948
Cdd:cd14143   203 IArrcSIGGIhedyqlPYYDLVPSDPSIEEMRKvvceqKLRPNIPNRwQSCEALRvmakIMRECWYANGAAR 274
STKc_CDC2L6 cd07867
Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6; STKs catalyze the ...
787-943 5.15e-05

Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L6 is also called CDK8-like and was previously referred to as CDK11. However, this is a confusing nomenclature as CDC2L6 is distinct from CDC2L1, which is represented by the two protein products from its gene, called CDK11(p110) and CDK11(p58), as well as the caspase-processed CDK11(p46). CDK11(p110), CDK11(p58), and CDK11(p46)do not belong to this subfamily. CDC2L6 is an associated protein of Mediator, a multiprotein complex that provides a platform to connect transcriptional and chromatin regulators and cofactors, in order to activate and mediate RNA polymerase II transcription. CDC2L6 is localized mainly in the nucleus amd exerts an opposing effect to CDK8 in VP16-dependent transcriptional activation by being a negative regulator. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270850 [Multi-domain]  Cd Length: 318  Bit Score: 46.60  E-value: 5.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  787 YRATLINDSPV-LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLIC----EGKLVKICDFGLARDIMRDSNYISKG 861
Cdd:cd07867    94 HRASKANKKPMqLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMgegpERGRVKIADMGFARLFNSPLKPLADL 173
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  862 STFLPLKWM-APESIFNSL-YTTLSDVWSFGILLWEIFTlggtpypelpmNDQFYNAIKRGYRMAQPAHAS--DEIYEIM 937
Cdd:cd07867   174 DPVVVTFWYrAPELLLGARhYTKAIDIWAIGCIFAELLT-----------SEPIFHCRQEDIKTSNPFHHDqlDRIFSVM 242
                         170
                  ....*....|
gi 226342982  938 ----QKCWEE 943
Cdd:cd07867   243 gfpaDKDWED 252
STKc_MSK1_C cd14179
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
823-904 6.46e-05

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK1 plays a role in the regulation of translational control and transcriptional activation. It phosphorylates the transcription factors, CREB and NFkB. It also phosphorylates the nucleosomal proteins H3 and HMG-14. Increased phosphorylation of MSK1 is associated with the development of cerebral ischemic/hypoxic preconditioning. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271081 [Multi-domain]  Cd Length: 310  Bit Score: 46.19  E-value: 6.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  823 VHRDLAARNVLIC---EGKLVKICDFGLARdIMRDSNYISKGSTFlPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTl 899
Cdd:cd14179   124 VHRDLKPENLLFTdesDNSEIKIIDFGFAR-LKPPDNQPLKTPCF-TLHYAAPELLNYNGYDESCDLWSLGVILYTMLS- 200

                  ....*
gi 226342982  900 GGTPY 904
Cdd:cd14179   201 GQVPF 205
STKc_MSK2_N cd05614
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
806-904 6.80e-05

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270765 [Multi-domain]  Cd Length: 332  Bit Score: 46.45  E-value: 6.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLI-CEGKLVkICDFGLARDIMRDsnyiSKGSTFL---PLKWMAPESIFN-SLY 880
Cdd:cd05614   110 YSGEIILALEHLHKLGIVYRDIKLENILLdSEGHVV-LTDFGLSKEFLTE----EKERTYSfcgTIEYMAPEIIRGkSGH 184
                          90       100
                  ....*....|....*....|....
gi 226342982  881 TTLSDVWSFGILLWEIFTlGGTPY 904
Cdd:cd05614   185 GKAVDWWSLGILMFELLT-GASPF 207
STKc_PKB cd05571
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B; STKs catalyze the transfer ...
814-896 7.18e-05

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. There are three PKB isoforms from different genes, PKB-alpha (or Akt1), PKB-beta (or Akt2), and PKB-gamma (or Akt3). PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. It is activated downstream of phosphoinositide 3-kinase (PI3K) and plays important roles in diverse cellular functions including cell survival, growth, proliferation, angiogenesis, motility, and migration. PKB also has a central role in a variety of human cancers, having been implicated in tumor initiation, progression, and metastasis. The PKB subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and PI3K.


Pssm-ID: 270723 [Multi-domain]  Cd Length: 322  Bit Score: 46.20  E-value: 7.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  814 MDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDimrDSNYISKGSTF--LPlKWMAPESIFNSLYTTLSDVWSFGI 891
Cdd:cd05571   108 LGYLHSQGIVYRDLKLENLLLDKDGHIKITDFGLCKE---EISYGATTKTFcgTP-EYLAPEVLEDNDYGRAVDWWGLGV 183

                  ....*
gi 226342982  892 LLWEI 896
Cdd:cd05571   184 VMYEM 188
PKc_CLK1_4 cd14213
Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4; ...
605-658 7.27e-05

Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. CLK1 plays a role in neuronal differentiation. CLKs are involved in the phosphorylation and regulation of serine/arginine-rich (SR) proteins, which play a crucial role in pre-mRNA splicing by directing splice site selection. SR proteins are phosphorylated first by SR protein kinases (SRPKs) at the N-terminus, which leads to its assembly into nuclear speckles where splicing factors are stored. CLKs phosphorylate the C-terminal part of SR proteins, causing the nuclear speckles to dissolve and splicing factors to be recruited at sites of active transcription. Based on a conserved "EHLAMMERILG" signature motif which may be crucial for substrate specificity, CLKs are also referred to as LAMMER kinases. CLKs autophosphorylate at tyrosine residues and phosphorylate their substrates exclusively on serine/threonine residues. The CLK1/4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271115 [Multi-domain]  Cd Length: 330  Bit Score: 46.38  E-value: 7.27e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 226342982  605 TLGSGAFGQVVEAtahgLSHSQATMKVAVKMLKSTARSSEkqALMSELKIMSHL 658
Cdd:cd14213    19 TLGEGAFGKVVEC----IDHKMGGMHVAVKIVKNVDRYRE--AARSEIQVLEHL 66
I-set pfam07679
Immunoglobulin I-set domain;
223-296 8.10e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 42.24  E-value: 8.10e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226342982   223 VVRQGESITIRCIVMGNDVVNFQWTyprmKSGRLVEPVTDYLFGVPSRIGSiLHIPTAELSDSGTYTCNVSVSV 296
Cdd:pfam07679   11 EVQEGESARFTCTVTGTPDPEVSWF----KDGQPLRSSDRFKVTYEGGTYT-LTISNVQPDDSGKYTCVATNSA 79
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
220-309 9.21e-05

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 42.18  E-value: 9.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   220 VQTVVRQGESITIRCIV-MGNDVVNFQWtypRMKSGRLVEPvTDYLFGVPSRIGSILHIPTAELSDSGTYTCnvsvSVND 298
Cdd:pfam00047    4 PTVTVLEGDSATLTCSAsTGSPGPDVTW---SKEGGTLIES-LKVKHDNGRTTQSSLLISNVTKEDAGTYTC----VVNN 75
                           90
                   ....*....|.
gi 226342982   299 HGDEKAINISV 309
Cdd:pfam00047   76 PGGSATLSTSL 86
IgI_6_Dscam cd20959
Sixth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
227-290 1.04e-04

Sixth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the sixth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409551  Cd Length: 94  Bit Score: 42.09  E-value: 1.04e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  227 GESITIRCIVMGNDV-VNFQWTyprmKSGrlvEPVTDYLFGVPSRIG---SILHIPTAELSDSGTYTC 290
Cdd:cd20959    17 GMRAQLHCGVPGGDLpLNIRWT----LDG---QPISDDLGITVSRLGrrsSILSIDSLEASHAGNYTC 77
STKc_CdkB_plant cd07837
Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase; ...
806-906 1.05e-04

Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CdkB subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270830 [Multi-domain]  Cd Length: 294  Bit Score: 45.60  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGK-LVKICDFGLARDI-MRDSNYISKGSTflpLKWMAPESIFNSL-YTT 882
Cdd:cd07837   114 FMYQLCKGVAHCHSHGVMHRDLKPQNLLVDKQKgLLKIADLGLGRAFtIPIKSYTHEIVT---LWYRAPEVLLGSThYST 190
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 226342982  883 LSDVWSFGIL-------------------LWEIFTLGGTPYPE 906
Cdd:cd07837   191 PVDMWSVGCIfaemsrkqplfpgdselqqLLHIFRLLGTPNEE 233
STKc_aPKC_zeta cd05617
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta; STKs catalyze ...
806-917 1.08e-04

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. The aPKC-zeta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270768 [Multi-domain]  Cd Length: 357  Bit Score: 45.78  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNyisKGSTFLPL-KWMAPESIFNSLYTTLS 884
Cdd:cd05617   121 YAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGD---TTSTFCGTpNYIAPEILRGEEYGFSV 197
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 226342982  885 DVWSFGILLWEIFTlGGTPY------PELPMNDQFYNAI 917
Cdd:cd05617   198 DWWALGVLMFEMMA-GRSPFdiitdnPDMNTEDYLFQVI 235
STK_BAK1_like cd14664
Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; ...
809-898 1.17e-04

Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes three leucine-rich repeat receptor-like kinases (LRR-RLKs): Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1), and Physcomitrella patens CLL1B clavata1-like receptor S/T protein kinase. BAK1 functions in various signaling pathways. It plays a role in BR (brassinosteroid)-regulated plant development as a co-receptor of BRASSINOSTEROID (BR) INSENSITIVE 1 (BRI1), the receptor for BRs, and is required for full activation of BR signaling. It also modulates pathways involved in plant resistance to pathogen infection (pattern-triggered immunity, PTI) and herbivore attack (wound- or herbivore feeding-induced accumulation of jasmonic acid (JA) and JA-isoleucine. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The STK_BAK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271134 [Multi-domain]  Cd Length: 270  Bit Score: 45.18  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFL---ASKNCVHRDLAARNVLICEGKLVKICDFGLARdIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSD 885
Cdd:cd14664   102 GSARGLAYLhhdCSPLIIHRDVKSNNILLDEEFEAHVADFGLAK-LMDDKDSHVMSSVAGSYGYIAPEYAYTGKVSEKSD 180
                          90
                  ....*....|...
gi 226342982  886 VWSFGILLWEIFT 898
Cdd:cd14664   181 VYSYGVVLLELIT 193
STKc_SGK3 cd05604
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
806-903 1.19e-04

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK3 (also called cytokine-independent survival kinase or CISK) is expressed in most tissues and is most abundant in the embryo and adult heart and spleen. It was originally discovered in a screen for antiapoptotic genes. It phosphorylates and inhibits the proapoptotic proteins, Bad and FKHRL1. SGK3 also regulates many transporters, ion channels, and receptors. It plays a critical role in hair follicle morphogenesis and hair cycling. The SGK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270755 [Multi-domain]  Cd Length: 326  Bit Score: 45.72  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNyisKGSTFLPL-KWMAPESIFNSLYTTLS 884
Cdd:cd05604   102 YAAEIASALGYLHSINIVYRDLKPENILLDSQGHIVLTDFGLCKEGISNSD---TTTTFCGTpEYLAPEVIRKQPYDNTV 178
                          90
                  ....*....|....*....
gi 226342982  885 DVWSFGILLWEIftLGGTP 903
Cdd:cd05604   179 DWWCLGSVLYEM--LYGLP 195
STKc_PINK1 cd14018
Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1; STKs catalyze ...
785-939 1.23e-04

Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PINK1 contains an N-terminal mitochondrial targeting sequence, a catalytic domain, and a C-terminal regulatory region. It plays an important role in maintaining mitochondrial homeostasis. It protects cells against oxidative stress-induced apoptosis by phosphorylating the chaperone TNFR-associated protein 1 (TRAP1), also called Hsp75. Phosphorylated TRAP1 prevents cytochrome c release and peroxide-induced apoptosis. PINK1 interacts with Omi/HtrA2, a serine protease, and Parkin, an E3 ubiquitin ligase, in different pathways to promote mitochondrial health. The parkin gene is the most commonly mutated gene in autosomal recessive familial parkinsonism. Mutations within the catalytic domain of PINK1 are also associated with Parkinson's disease. The PINK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270920 [Multi-domain]  Cd Length: 313  Bit Score: 45.56  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  785 RTYRATLIN--DSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLI------CEgKLVkICDFG--LARDIMR- 853
Cdd:cd14018   120 KNYPCTLRQylWVNTPSYRLARVMILQLLEGVDHLVRHGIAHRDLKSDNILLeldfdgCP-WLV-IADFGccLADDSIGl 197
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  854 ----DSNYISKGSTflpLKWMAPEsIFNS-------LYTTLSDVWSFGILLWEIFTLggtPYPelpmndqFY-----NAI 917
Cdd:cd14018   198 qlpfSSWYVDRGGN---ACLMAPE-VSTAvpgpgvvINYSKADAWAVGAIAYEIFGL---SNP-------FYglgdtMLE 263
                         170       180       190
                  ....*....|....*....|....*....|
gi 226342982  918 KRGYRMAQ----PAHASDE----IYEIMQK 939
Cdd:cd14018   264 SRSYQESQlpalPSAVPPDvrqvVKDLLQR 293
STKc_SGK cd05575
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; ...
806-895 1.30e-04

Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGKs are activated by insulin and growth factors via phosphoinositide 3-kinase and PDK1. They activate ion channels, ion carriers, and the Na-K-ATPase, as well as regulate the activity of enzymes and transcription factors. SGKs play important roles in transport, hormone release, neuroexcitability, cell proliferation, and apoptosis. There are three isoforms of SGK, named SGK1, SGK2, and SGK3 (also called cytokine-independent survival kinase CISK). The SGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270727 [Multi-domain]  Cd Length: 323  Bit Score: 45.39  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLI-CEGKLVkICDFGLARDIMRDSnyiSKGSTF--LPlKWMAPESIFNSLYTT 882
Cdd:cd05575   101 YAAEIASALGYLHSLNIIYRDLKPENILLdSQGHVV-LTDFGLCKEGIEPS---DTTSTFcgTP-EYLAPEVLRKQPYDR 175
                          90
                  ....*....|...
gi 226342982  883 LSDVWSFGILLWE 895
Cdd:cd05575   176 TVDWWCLGAVLYE 188
STKc_CaMKI_beta cd14169
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
799-945 1.31e-04

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271071 [Multi-domain]  Cd Length: 277  Bit Score: 45.27  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  799 SYT--DLVGFSYQVANGMDFLASKNCVHRDLAARNVLIC---EGKLVKICDFGLARdiMRDSNYISKGSTfLPlKWMAPE 873
Cdd:cd14169    97 SYTekDASQLIGQVLQAVKYLHQLGIVHRDLKPENLLYAtpfEDSKIMISDFGLSK--IEAQGMLSTACG-TP-GYVAPE 172
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  874 SIFNSLYTTLSDVWSFGILLWeIFTLGGTPYPELPMNDQFYNAIKRGYRMAQP------AHASDEIYEIMQKCWEEKF 945
Cdd:cd14169   173 LLEQKPYGKAVDVWAIGVISY-ILLCGYPPFYDENDSELFNQILKAEYEFDSPywddisESAKDFIRHLLERDPEKRF 249
STKc_CaMKI_delta cd14168
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
809-939 1.83e-04

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-delta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271070 [Multi-domain]  Cd Length: 301  Bit Score: 44.65  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLIC---EGKLVKICDFGLARdiMRDSNYISKGSTFLPlKWMAPESIFNSLYTTLSD 885
Cdd:cd14168   116 QVLDAVYYLHRMGIVHRDLKPENLLYFsqdEESKIMISDFGLSK--MEGKGDVMSTACGTP-GYVAPEVLAQKPYSKAVD 192
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  886 VWSFGILLWeIFTLGGTPYPELPMNDQFYNAIKRGYRMAQP------AHASDEIYEIMQK 939
Cdd:cd14168   193 CWSIGVIAY-ILLCGYPPFYDENDSKLFEQILKADYEFDSPywddisDSAKDFIRNLMEK 251
PHA03212 PHA03212
serine/threonine kinase US3; Provisional
787-898 1.93e-04

serine/threonine kinase US3; Provisional


Pssm-ID: 165478 [Multi-domain]  Cd Length: 391  Bit Score: 44.99  E-value: 1.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  787 YRATL---INDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLA---RDIMRDSNYISK 860
Cdd:PHA03212  165 YKTDLycyLAAKRNIAICDILAIERSVLRAIQYLHENRIIHRDIKAENIFINHPGDVCLGDFGAAcfpVDINANKYYGWA 244
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 226342982  861 GStflpLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT 898
Cdd:PHA03212  245 GT----IATNAPELLARDPYGPAVDIWSAGIVLFEMAT 278
STKc_GRK7 cd05607
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; ...
806-904 2.05e-04

Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK7 (also called iodopsin kinase) belongs to the visual group of GRKs. It is primarily found in the retina and plays a role in the regulation of opsin light receptors. GRK7 is located in retinal cone outer segments and plays an important role in regulating photoresponse of the cones. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270758 [Multi-domain]  Cd Length: 286  Bit Score: 44.51  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFlplKWMAPESIFNSLYTTLSD 885
Cdd:cd05607   109 YSAQITCGILHLHSLKIVYRDMKPENVLLDDNGNCRLSDLGLAVEVKEGKPITQRAGTN---GYMAPEILKEESYSYPVD 185
                          90
                  ....*....|....*....
gi 226342982  886 VWSFGILLWEIFTlGGTPY 904
Cdd:cd05607   186 WFAMGCSIYEMVA-GRTPF 203
pknD PRK13184
serine/threonine-protein kinase PknD;
809-904 2.20e-04

serine/threonine-protein kinase PknD;


Pssm-ID: 183880 [Multi-domain]  Cd Length: 932  Bit Score: 45.53  E-value: 2.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLA------RDIMRDSNYISKGSTF----LPLK------WMAP 872
Cdd:PRK13184  121 KICATIEYVHSKGVLHRDLKPDNILLGLFGEVVILDWGAAifkkleEEDLLDIDVDERNICYssmtIPGKivgtpdYMAP 200
                          90       100       110
                  ....*....|....*....|....*....|..
gi 226342982  873 ESIFNSLYTTLSDVWSFGILLWEIFTLgGTPY 904
Cdd:PRK13184  201 ERLLGVPASESTDIYALGVILYQMLTL-SFPY 231
STKc_GRK3 cd05633
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3; STKs ...
797-912 2.27e-04

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK3, also called beta-adrenergic receptor kinase 2 (beta-ARK2), is widely expressed in many tissues. It is involved in modulating the cholinergic response of airway smooth muscles, and also plays a role in dopamine receptor regulation. GRK3-deficient mice show a lack of olfactory receptor desensitization and altered regulation of the M2 muscarinic airway. GRK3 promoter polymorphisms may also be associated with bipolar disorder. GRK3 contains an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270781 [Multi-domain]  Cd Length: 346  Bit Score: 44.67  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  797 VLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTflplKWMAPESIF 876
Cdd:cd05633   104 VFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH----GYMAPEVLQ 179
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 226342982  877 N-SLYTTLSDVWSFGILLWEIFTlGGTPYPELPMNDQ 912
Cdd:cd05633   180 KgTAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDK 215
STKc_LATS cd05598
Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor; STKs catalyze the ...
823-903 2.30e-04

Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS was originally identified in Drosophila using a screen for genes whose inactivation led to overproliferation of cells. In tetrapods, there are two LATS isoforms, LATS1 and LATS2. Inactivation of LATS1 in mice results in the development of various tumors, including sarcomas and ovarian cancer. LATS functions as a tumor suppressor and is implicated in cell cycle regulation. The LATS subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270749 [Multi-domain]  Cd Length: 333  Bit Score: 44.62  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  823 VHRDLAARNVLICEGKLVKICDFGLARDI--MRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIftLG 900
Cdd:cd05598   123 IHRDIKPDNILIDRDGHIKLTDFGLCTGFrwTHDSKYYLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILYEM--LV 200

                  ...
gi 226342982  901 GTP 903
Cdd:cd05598   201 GQP 203
PKc_DYRK2_3 cd14224
Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and ...
806-912 2.38e-04

Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of DYRK2 and DYRK3, and similar proteins. Drosophila DYRK2 interacts and phosphorylates the chromatin remodelling factor, SNR1 (Snf5-related 1), and also interacts with the essential chromatin component, trithorax. It may play a role in chromatin remodelling. Vertebrate DYRK2 phosphorylates and regulates the tumor suppressor p53 to induce apoptosis in response to DNA damage. It can also phosphorylate the transcription factor, nuclear factor of activated T cells (NFAT). DYRK2 is overexpressed in lung adenocarcinoma and esophageal carcinomas, and is a predictor for favorable prognosis in lung adenocarcinoma. DYRK3, also called regulatory erythroid kinase (REDK), is highly expressed in erythroid cells and the testis, and is also present in adult kidney and liver. It promotes cell survival by phosphorylating and activating SIRT1, an NAD(+)-dependent protein deacetylase, which promotes p53 deacetylation, resulting in the inhibition of apoptosis. DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. The DYRK2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other S/T kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271126 [Multi-domain]  Cd Length: 380  Bit Score: 44.74  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICE-GKL-VKICDFGLA-RDIMRDSNYISkgSTFlplkWMAPESIFNSLYTT 882
Cdd:cd14224   173 FAHSILQCLDALHRNKIIHCDLKPENILLKQqGRSgIKVIDFGSScYEHQRIYTYIQ--SRF----YRAPEVILGARYGM 246
                          90       100       110
                  ....*....|....*....|....*....|
gi 226342982  883 LSDVWSFGILLWEIFtlggTPYPELPMNDQ 912
Cdd:cd14224   247 PIDMWSFGCILAELL----TGYPLFPGEDE 272
STKc_EIF2AK4_GCN2_rpt2 cd14046
Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation ...
606-698 2.39e-04

Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GCN2 (or EIF2AK4) is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. Its kinase domain is activated via conformational changes as a result of the binding of uncharged tRNA to the HisRS-like domain. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270948 [Multi-domain]  Cd Length: 278  Bit Score: 44.28  E-value: 2.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  606 LGSGAFGQVVeatahglshsqatmKV---------AVKMLKSTARSSEKQALMSELKIMSHLGpHLNVVNLLGACTKGGP 676
Cdd:cd14046    14 LGKGAFGQVV--------------KVrnkldgryyAIKKIKLRSESKNNSRILREVMLLSRLN-HQHVVRYYQAWIERAN 78
                          90       100
                  ....*....|....*....|..
gi 226342982  677 IYIITEYCRYGDLVDYLHRNKH 698
Cdd:cd14046    79 LYIQMEYCEKSTLRDLIDSGLF 100
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
823-920 2.69e-04

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 45.11  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  823 VHRDLAARNVLICEG-----------------KLVKICDFGLARDIMRDSnyISKGSTFLPLKWmAPESIFNSL--YTTL 883
Cdd:PTZ00266  147 LHRDLKPQNIFLSTGirhigkitaqannlngrPIAKIGDFGLSKNIGIES--MAHSCVGTPYYW-SPELLLHETksYDDK 223
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 226342982  884 SDVWSFGILLWEIFTlGGTPYPELPMNDQFYNAIKRG 920
Cdd:PTZ00266  224 SDMWALGCIIYELCS-GKTPFHKANNFSQLISELKRG 259
PHA03210 PHA03210
serine/threonine kinase US3; Provisional
794-932 3.06e-04

serine/threonine kinase US3; Provisional


Pssm-ID: 165476 [Multi-domain]  Cd Length: 501  Bit Score: 44.68  E-value: 3.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  794 DSPVLSYTDLVgfSYQVANGMDFLASKNCVHRDLAARNVLI-CEGKLVkICDFGLARD-----IMRDSNYISKGSTflpl 867
Cdd:PHA03210  262 DRPLLKQTRAI--MKQLLCAVEYIHDKKLIHRDIKLENIFLnCDGKIV-LGDFGTAMPfekerEAFDYGWVGTVAT---- 334
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226342982  868 kwMAPESIFNSLYTTLSDVWSFGILLWEIFTlggtpYPELPMNDQFYNAIKRGYRMAQPAHASDE 932
Cdd:PHA03210  335 --NSPEILAGDGYCEITDIWSCGLILLDMLS-----HDFCPIGDGGGKPGKQLLKIIDSLSVCDE 392
STKc_CaMKI cd14083
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
799-945 3.09e-04

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270985 [Multi-domain]  Cd Length: 259  Bit Score: 43.90  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  799 SYT-----DLVGfsyQVANGMDFLASKNCVHRDLAARNVLIC---EGKLVKICDFGLARdiMRDSNYISK--GSTflplK 868
Cdd:cd14083    97 SYTekdasHLIR---QVLEAVDYLHSLGIVHRDLKPENLLYYspdEDSKIMISDFGLSK--MEDSGVMSTacGTP----G 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  869 WMAPESIFNSLYTTLSDVWSFGILLWeIFTLGGTP-YPElpmNDQ-FYNAIKRG-YRMAQP------AHASDEIYEIMQK 939
Cdd:cd14083   168 YVAPEVLAQKPYGKAVDCWSIGVISY-ILLCGYPPfYDE---NDSkLFAQILKAeYEFDSPywddisDSAKDFIRHLMEK 243

                  ....*.
gi 226342982  940 CWEEKF 945
Cdd:cd14083   244 DPNKRY 249
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
49-106 3.21e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 40.01  E-value: 3.21e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982   49 FVLTCSGSAP----VMWE-QMSQVPWQEAAMNQDGTFSSVLTLTNVTGGDTGEYFCVYNNSLG 106
Cdd:cd00096     1 VTLTCSASGNppptITWYkNGKPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAG 63
STKc_HUNK cd14070
Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase ...
809-910 3.21e-04

Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HUNK/MAK-V was identified from a mammary tumor in an MMTV-neu transgenic mouse. It is required for the metastasis of c-myc-induced mammary tumors, but is not necessary for c-myc-induced primary tumor formation or normal development. It is required for HER2/neu-induced tumor formation and maintenance of the cells' tumorigenic phenotype. It is over-expressed in aggressive subsets of ovary, colon, and breast carcinomas. HUNK interacts with synaptopodin, and may also play a role in synaptic plasticity. The HUNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270972 [Multi-domain]  Cd Length: 262  Bit Score: 43.65  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI----MRDSNYISKGSTflplKWMAPESIFNSLYTTLS 884
Cdd:cd14070   111 QLVSAVEHLHRAGVVHRDLKIENLLLDENDNIKLIDFGLSNCAgilgYSDPFSTQCGSP----AYAAPELLARKKYGPKV 186
                          90       100
                  ....*....|....*....|....*.
gi 226342982  885 DVWSFGILLWEIFTlGGTPYPELPMN 910
Cdd:cd14070   187 DVWSIGVNMYAMLT-GTLPFTVEPFS 211
STKc_NIK cd13991
Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK); STKs ...
809-888 3.24e-04

Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIK, also called mitogen activated protein kinase kinase kinase 14 (MAP3K14), phosphorylates and activates Inhibitor of NF-KappaB Kinase (IKK) alpha, which is a regulator of NF-kB proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. NIK is essential in the IKKalpha-mediated non-canonical NF-kB signaling pathway, in which IKKalpha processes the IkB-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus where it regulates gene transcription. NIK also plays an important role in Toll-like receptor 7/9 signaling cascades. The NIK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270893 [Multi-domain]  Cd Length: 268  Bit Score: 43.65  E-value: 3.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICE-GKLVKICDFGLARDIMRD--------SNYISKGSTFlplkwMAPESIFNSL 879
Cdd:cd13991   106 QALEGLEYLHSRKILHGDVKADNVLLSSdGSDAFLCDFGHAECLDPDglgkslftGDYIPGTETH-----MAPEVVLGKP 180

                  ....*....
gi 226342982  880 YTTLSDVWS 888
Cdd:cd13991   181 CDAKVDVWS 189
STKc_IRAK1 cd14159
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 1; ...
794-898 3.38e-04

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK1 plays a role in the activation of IRF3/7, STAT, and NFkB. It mediates IL-6 and IFN-gamma responses following IL-1 and IL-18 stimulation, respectively. It also plays an essential role in IFN-alpha induction downstream of TLR7 and TLR9. The IRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271061 [Multi-domain]  Cd Length: 296  Bit Score: 44.05  E-value: 3.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  794 DSPVLSYTDLVGFSYQVANGMDFL--ASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNyISKGSTFL------ 865
Cdd:cd14159    88 SCPCLSWSQRLHVLLGTARAIQYLhsDSPSLIHGDVKSSNILLDAALNPKLGDFGLARFSRRPKQ-PGMSSTLArtqtvr 166
                          90       100       110
                  ....*....|....*....|....*....|....
gi 226342982  866 -PLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT 898
Cdd:cd14159   167 gTLAYLPEEYVKTGTLSVEIDVYSFGVVLLELLT 200
STKc_KIS cd14020
Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called ...
810-898 3.72e-04

Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. KIS (or UHMK1) contains an N-terminal kinase domain and a C-terminal domain with a UHM motif, a protein interaction motif initially found in the pre-mRNA splicing factor U2AF. It phosphorylates the splicing factor SF1, which enhances binding to the splice site to promote spliceosome assembly. KIS was first identified as a kinase that interacts with stathmin, a phosphoprotein that plays a role in axon development and microtubule dynamics. It localizes in RNA granules in neurons and is important in neurite outgrowth. The KIS/UHMK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270922 [Multi-domain]  Cd Length: 285  Bit Score: 43.77  E-value: 3.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVL-ICEGKLVKICDFGLA-RDIMRDSNYISKGStflplkWMAPES-IFNSLY------ 880
Cdd:cd14020   119 VLEALAFLHHEGYVHADLKPRNILwSAEDECFKLIDFGLSfKEGNQDVKYIQTDG------YRAPEAeLQNCLAqaglqs 192
                          90       100
                  ....*....|....*....|..
gi 226342982  881 ----TTLSDVWSFGILLWEIFT 898
Cdd:cd14020   193 etecTSAVDLWSLGIVLLEMFS 214
STKc_MSK_N cd05583
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
814-904 3.91e-04

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270735 [Multi-domain]  Cd Length: 268  Bit Score: 43.54  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  814 MDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYisKGSTFL-PLKWMAPESIF--NSLYTTLSDVWSFG 890
Cdd:cd05583   112 LEHLHKLGIIYRDIKLENILLDSEGHVVLTDFGLSKEFLPGEND--RAYSFCgTIEYMAPEVVRggSDGHDKAVDWWSLG 189
                          90
                  ....*....|....
gi 226342982  891 ILLWEIFTlGGTPY 904
Cdd:cd05583   190 VLTYELLT-GASPF 202
STKc_MRCK_beta cd05624
Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control ...
823-944 5.44e-04

Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MRCK-beta is expressed ubiquitously in many tissues. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. The MRCK-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This alignment model includes the dimerization domain.


Pssm-ID: 270774 [Multi-domain]  Cd Length: 409  Bit Score: 43.84  E-value: 5.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  823 VHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPlKWMAPEsIFNSL------YTTLSDVWSFGILLWEI 896
Cdd:cd05624   195 VHRDIKPDNVLLDMNGHIRLADFGSCLKMNDDGTVQSSVAVGTP-DYISPE-ILQAMedgmgkYGPECDWWSLGVCMYEM 272
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 226342982  897 FtLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASD---EIYEIMQK--CWEEK 944
Cdd:cd05624   273 L-YGETPFYAESLVETYGKIMNHEERFQFPSHVTDvseEAKDLIQRliCSRER 324
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
334-394 6.02e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.47  E-value: 6.02e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226342982   334 TLRVVFEAYPMPSVLWLKDNRTLGDSgagelvlSTRNMSETRYVSELILVRVKVSEAGYYT 394
Cdd:pfam13927   20 TLTCEATGSPPPTITWYKNGEPISSG-------STRSRSLSGSNSTLTISNVTRSDAGTYT 73
STKc_HIPK2 cd14227
Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2; ...
809-912 6.16e-04

Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HIPK2, the most studied HIPK, is a coregulator of many transcription factors and cofactors including homeodomain proteins (Nkx and HOX families), Smad1-4, Pax6, c-Myb, AML1, the histone acetyltransferase p300, and the tumor repressor p53, among others. It regulates gene transcription during development and in DNA damage response (DDR), and mediates cell processes such as apoptosis, survival, differentiation, and proliferation. HIPK2 mediates apoptosis by phosphorylating and activating p53 during DDR, resulting in the activation of apoptotic genes. In the absence of p53, HIPK2 targets the anti-apoptotic corepressor C-terminal binding protein (CtBP), leading to CtBP's degradation and the promotion of apoptosis. HIPKs, originally identified by their ability to bind homeobox factors, are nuclear proteins containing catalytic kinase and homeobox-interacting domains as well as a PEST region overlapping with the speckle-retention signal (SRS). The HIPK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271129 [Multi-domain]  Cd Length: 355  Bit Score: 43.54  E-value: 6.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKL----VKICDFGLArdimrdsNYISKG--STFLPLKWM-APESIFNSLYT 881
Cdd:cd14227   125 QVATALMKLKSLGLIHADLKPENIMLVDPSRqpyrVKVIDFGSA-------SHVSKAvcSTYLQSRYYrAPEIILGLPFC 197
                          90       100       110
                  ....*....|....*....|....*....|.
gi 226342982  882 TLSDVWSFGILLWEIFtLGGTPYPELPMNDQ 912
Cdd:cd14227   198 EAIDMWSLGCVIAELF-LGWPLYPGASEYDQ 227
STKc_MAPKAPK2 cd14170
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
810-943 6.25e-04

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 2 (MAPKAP2 or MK2) contains an N-terminal proline-rich region that can bind to SH3 domains, a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK2 is a bonafide substrate for the MAPK p38. It is closely related to MK3 and thus far, MK2/3 show indistinguishable substrate specificity. They are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. The MK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271072 [Multi-domain]  Cd Length: 303  Bit Score: 43.10  E-value: 6.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLICEGK---LVKICDFGLARDIMRDSNYISkgSTFLPLkWMAPESIFNSLYTTLSDV 886
Cdd:cd14170   110 IGEAIQYLHSINIAHRDVKPENLLYTSKRpnaILKLTDFGFAKETTSHNSLTT--PCYTPY-YVAPEVLGPEKYDKSCDM 186
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 226342982  887 WSFGILLWeIFTLGgtpYPELPMNDQF--YNAIKRGYRMAQpahasdeiYEIMQKCWEE 943
Cdd:cd14170   187 WSLGVIMY-ILLCG---YPPFYSNHGLaiSPGMKTRIRMGQ--------YEFPNPEWSE 233
IgI_2_FGFR_like cd05729
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, and similar ...
335-412 7.47e-04

Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, and similar domains; member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor. FGF receptors bind FGF signaling polypeptides. FGFs participate in multiple processes such as morphogenesis, development, and angiogenesis. FGFs bind to four FGF receptor tyrosine kinases (FGFR1, FGFR2, FGFR3, FGFR4). Receptor diversity is controlled by alternative splicing producing splice variants with different ligand binding characteristics and different expression patterns. FGFRs have an extracellular region comprised of three Ig-like domains, a single transmembrane helix, and an intracellular tyrosine kinase domain. Ligand binding and specificity reside in the Ig-like domains 2 and 3, and the linker region that connects these two. FGFR activation and signaling depend on FGF-induced dimerization, a process involving cell surface heparin or heparin sulfate proteoglycans. This group also contains fibroblast growth factor (FGF) receptor like-1(FGFRL1). FGFRL1 does not have a protein tyrosine kinase domain at its C-terminus; neither does its cytoplasmic domain appear to interact with a signaling partner. It has been suggested that FGFRL1 may not have any direct signaling function, but instead acts as a decoy receptor trapping FGFs and preventing them from binding other receptors.


Pssm-ID: 409393 [Multi-domain]  Cd Length: 95  Bit Score: 39.90  E-value: 7.47e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  335 LRVVFEAYPMPSVLWLKDNRTLGDsgagELVLSTRNMSETRYVseLILVRVKVSEAGYYTMRAFHEDDEVQLSFKLQV 412
Cdd:cd05729    24 LECGAGGNPMPNITWLKDGKEFKK----EHRIGGTKVEEKGWS--LIIERAIPRDKGKYTCIVENEYGSINHTYDVDV 95
STKc_HIPK1 cd14228
Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1; ...
809-912 8.88e-04

Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HIPK1 has been implicated in regulating eye size, lens formation, and retinal morphogenesis during late embryogenesis. It also contributes to the regulation of haematopoiesis and leukaemogenesis by phosphorylating and repressing the transcription factor c-Myb, which is crucial in T- and B-cell development. In glucose-deprived conditions, HIPK1 phosphorylates Daxx, leading to its relocalization from the nucleus to the cytoplasm, where it binds and stabilizes ASK1 (apoptosis signal-regulating kinase 1), a mitogen-activated protein kinase (MAPK) kinase kinase that activates the JNK and p38 MAPK pathways. HIPKs, originally identified by their ability to bind homeobox factors, are nuclear proteins containing catalytic kinase and homeobox-interacting domains as well as a PEST region overlapping with the speckle-retention signal (SRS). The HIPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271130 [Multi-domain]  Cd Length: 355  Bit Score: 42.77  E-value: 8.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLIC----EGKLVKICDFGLArdimrdsNYISKG--STFLPLKWM-APESIFNSLYT 881
Cdd:cd14228   125 QVATALMKLKSLGLIHADLKPENIMLVdpvrQPYRVKVIDFGSA-------SHVSKAvcSTYLQSRYYrAPEIILGLPFC 197
                          90       100       110
                  ....*....|....*....|....*....|.
gi 226342982  882 TLSDVWSFGILLWEIFtLGGTPYPELPMNDQ 912
Cdd:cd14228   198 EAIDMWSLGCVIAELF-LGWPLYPGASEYDQ 227
STKc_TGFbR2_like cd14055
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II ...
797-948 9.13e-04

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TGFbR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as TGFbR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. TGFbR2 acts as the receptor for TGFbeta, which is crucial in growth control and homeostasis in many different tissues. It plays roles in regulating apoptosis and in maintaining the balance between self renewal and cell loss. It also plays a key role in maintaining vascular integrity and in regulating responses to genotoxic stress. Mutations in TGFbR2 can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. The TGFbR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270957 [Multi-domain]  Cd Length: 295  Bit Score: 42.75  E-value: 9.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  797 VLSYTDLVGFSYQVANGMDFLASKN---------CVHRDLAARNVLI-CEGKLVkICDFGLA--------RDIMRDSNYI 858
Cdd:cd14055    94 ILSWEDLCKMAGSLARGLAHLHSDRtpcgrpkipIAHRDLKSSNILVkNDGTCV-LADFGLAlrldpslsVDELANSGQV 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  859 skgSTFlplKWMAPESI--------FNSLYTTlsDVWSFGILLWEIF----TLGGTPYPELP-------------MNDqf 913
Cdd:cd14055   173 ---GTA---RYMAPEALesrvnledLESFKQI--DVYSMALVLWEMAsrceASGEVKPYELPfgskvrerpcvesMKD-- 242
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 226342982  914 yNAIKRGYRMAQPA----H-ASDEIYEIMQKCWEEKFETR 948
Cdd:cd14055   243 -LVLRDRGRPEIPDswltHqGMCVLCDTITECWDHDPEAR 281
STKc_PSKH1 cd14087
Catalytic domain of the Protein Serine/Threonine kinase H1; STKs catalyze the transfer of the ...
810-920 9.18e-04

Catalytic domain of the Protein Serine/Threonine kinase H1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PSKH1 is an autophosphorylating STK that is expressed ubiquitously and exhibits multiple intracellular localizations including the centrosome, Golgi apparatus, and splice factor compartments. It contains a catalytic kinase domain and an N-terminal SH4-like motif that is acylated to facilitate membrane attachment. PSKH1 plays a rile in the maintenance of the Golgi apparatus, an important organelle within the secretory pathway. It may also function as a novel splice factor and a regulator of prostate cancer cell growth. The PSKH1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270989 [Multi-domain]  Cd Length: 259  Bit Score: 42.52  E-value: 9.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLIC----EGKLVkICDFGLARDIMRDSNYISKGSTFLPlKWMAPESIFNSLYTTLSD 885
Cdd:cd14087   106 VLDGVKYLHGLGITHRDLKPENLLYYhpgpDSKIM-ITDFGLASTRKKGPNCLMKTTCGTP-EYIAPEILLRKPYTQSVD 183
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 226342982  886 VWSFGILLWeiFTLGGTpypeLPMND----QFYNAIKRG 920
Cdd:cd14087   184 MWAVGVIAY--ILLSGT----MPFDDdnrtRLYRQILRA 216
STKc_PhKG1 cd14182
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit; STKs ...
814-903 9.27e-04

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). The gamma 1 subunit (PhKG1) is also referred to as the muscle gamma isoform. The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271084 [Multi-domain]  Cd Length: 276  Bit Score: 42.59  E-value: 9.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  814 MDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDImrDSNYISKGSTFLPlKWMAPESIFNSL------YTTLSDVW 887
Cdd:cd14182   123 ICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQL--DPGEKLREVCGTP-GYLAPEIIECSMddnhpgYGKEVDMW 199
                          90
                  ....*....|....*.
gi 226342982  888 SFGILLWEIftLGGTP 903
Cdd:cd14182   200 STGVIMYTL--LAGSP 213
PHA03211 PHA03211
serine/threonine kinase US3; Provisional
798-929 1.03e-03

serine/threonine kinase US3; Provisional


Pssm-ID: 223009 [Multi-domain]  Cd Length: 461  Bit Score: 42.96  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  798 LSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLArdimrdsnYISKGSTFLPLKW-------- 869
Cdd:PHA03211  257 LGLAQVTAVARQLLSAIDYIHGEGIIHRDIKTENVLVNGPEDICLGDFGAA--------CFARGSWSTPFHYgiagtvdt 328
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  870 MAPESIFNSLYTTLSDVWSFGILLWE--IFTLGGTPYPELPMNDQFYNAIKRGYRMAQ------PAHA 929
Cdd:PHA03211  329 NAPEVLAGDPYTPSVDIWSAGLVIFEaaVHTASLFSASRGDERRPYDAQILRIIRQAQvhvdefPQHA 396
STKc_aPKC cd05588
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C; STKs catalyze the ...
806-911 1.29e-03

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270740 [Multi-domain]  Cd Length: 328  Bit Score: 42.41  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYIskgSTF--LPlKWMAPESIFNSLYTTL 883
Cdd:cd05588   101 YSAEISLALNFLHEKGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT---STFcgTP-NYIAPEILRGEDYGFS 176
                          90       100
                  ....*....|....*....|....*...
gi 226342982  884 SDVWSFGILLWEIFTlGGTPYPELPMND 911
Cdd:cd05588   177 VDWWALGVLMFEMLA-GRSPFDIVGSSD 203
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
334-394 1.55e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 38.08  E-value: 1.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226342982  334 TLRVVFEAYPMPSVLWLKDNRTLGDSGAGELVLSTRNmsetryvSELILVRVKVSEAGYYT 394
Cdd:cd00096     2 TLTCSASGNPPPTITWYKNGKPLPPSSRDSRRSELGN-------GTLTISNVTLEDSGTYT 55
STKc_Aurora-B_like cd14117
Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins; STKs ...
809-917 1.58e-03

Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). This subfamily includes Aurora-B and Aurora-C. Aurora-B is most active at the transition during metaphase to the end of mitosis. It associates with centromeres, relocates to the midzone of the central spindle, and concentrates at the midbody during cell division. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. INCENP participates in the activation of Aurora-B in a two-step process: first by binding to form an intermediate state of activation and the phosphorylation of its C-terminal TSS motif to generate the fully active kinase. The Aurora-B subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271019 [Multi-domain]  Cd Length: 270  Bit Score: 41.77  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFG-------LARDIMRDSnyiskgstflpLKWMAPESIFNSLYT 881
Cdd:cd14117   114 ELADALHYCHEKKVIHRDIKPENLLMGYKGELKIADFGwsvhapsLRRRTMCGT-----------LDYLPPEMIEGRTHD 182
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 226342982  882 TLSDVWSFGILLWEIftLGGTPYPELPMNDQFYNAI 917
Cdd:cd14117   183 EKVDLWCIGVLCYEL--LVGMPPFESASHTETYRRI 216
PKc_DYRK1 cd14226
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
806-898 1.80e-03

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. Mammals contain two types of DYRK1 proteins, DYRK1A and DYRK1B. DYRK1A was previously called minibrain kinase homolog (MNBH) or dual-specificity YAK1-related kinase. It phosphorylates various substrates and is involved in many cellular events. It phosphorylates and inhibits the transcription factors, nuclear factor of activated T cells (NFAT) and forkhead in rhabdomyosarcoma (FKHR). It regulates neuronal differentiation by targetting CREB (cAMP response element-binding protein). It also targets many endocytic proteins including dynamin and amphiphysin and may play a role in the endocytic pathway. The gene encoding DYRK1A is located in the DSCR (Down syndrome critical region) of human chromosome 21 and DYRK1A has been implicated in the pathogenesis of DS. DYRK1B, also called minibrain-related kinase (MIRK), is highly expressed in muscle and plays a critical role in muscle differentiation by regulating transcription, cell motility, survival, and cell cycle progression. It is overexpressed in many solid tumors where it acts as a tumor survival factor. DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. The DYRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271128 [Multi-domain]  Cd Length: 339  Bit Score: 41.92  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASK--NCVHRDLAARNVLICEGKL--VKICDFG----LARDIMRdsnYISkgSTFlplkWMAPESIFN 877
Cdd:cd14226   121 FAQQLCTALLFLSTPelSIIHCDLKPENILLCNPKRsaIKIIDFGsscqLGQRIYQ---YIQ--SRF----YRSPEVLLG 191
                          90       100
                  ....*....|....*....|.
gi 226342982  878 SLYTTLSDVWSFGILLWEIFT 898
Cdd:cd14226   192 LPYDLAIDMWSLGCILVEMHT 212
STKc_HUNK cd14070
Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase ...
601-708 1.82e-03

Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HUNK/MAK-V was identified from a mammary tumor in an MMTV-neu transgenic mouse. It is required for the metastasis of c-myc-induced mammary tumors, but is not necessary for c-myc-induced primary tumor formation or normal development. It is required for HER2/neu-induced tumor formation and maintenance of the cells' tumorigenic phenotype. It is over-expressed in aggressive subsets of ovary, colon, and breast carcinomas. HUNK interacts with synaptopodin, and may also play a role in synaptic plasticity. The HUNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270972 [Multi-domain]  Cd Length: 262  Bit Score: 41.34  E-value: 1.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  601 VLGRTLGSGAFGQVVEatahGLsHSQATMKVAVKML-KSTAR--SSEKQALMSELKIMSHLgPHLNVVNLLGACTKGGPI 677
Cdd:cd14070     5 LIGRKLGEGSFAKVRE----GL-HAVTGEKVAIKVIdKKKAKkdSYVTKNLRREGRIQQMI-RHPNITQLLDILETENSY 78
                          90       100       110
                  ....*....|....*....|....*....|.
gi 226342982  678 YIITEYCRYGDLVDYLHrNKHTFLQRHSNKH 708
Cdd:cd14070    79 YLVMELCPGGNLMHRIY-DKKRLEEREARRY 108
STKc_MAPKAPK3 cd14172
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
810-949 2.47e-03

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 3 (MAPKAP3 or MK3) contains an N-terminal proline-rich region that can bind to SH3 domains, a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK3 is a bonafide substrate for the MAPK p38. It is closely related to MK2 and thus far, MK2/3 show indistinguishable substrate specificity. They are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. MK3 activity is only significant when MK2 is absent. The MK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271074 [Multi-domain]  Cd Length: 267  Bit Score: 41.13  E-value: 2.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  810 VANGMDFLASKNCVHRDLAARNVLICEGK---LVKICDFGLARDIMRDSNYisKGSTFLPLkWMAPESIFNSLYTTLSDV 886
Cdd:cd14172   112 IGTAIQYLHSMNIAHRDVKPENLLYTSKEkdaVLKLTDFGFAKETTVQNAL--QTPCYTPY-YVAPEVLGPEKYDKSCDM 188
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226342982  887 WSFGILLWeIFTLGgtpYPELPMN--DQFYNAIKRGYRMAQ---PAHASDEIYEIMQKCWEEKFETRP 949
Cdd:cd14172   189 WSLGVIMY-ILLCG---FPPFYSNtgQAISPGMKRRIRMGQygfPNPEWAEVSEEAKQLIRHLLKTDP 252
Ig4_L1-NrCAM_like cd04978
Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), ...
33-109 2.48e-03

Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related); The members here are composed of the fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related). These proteins belong to the L1 subfamily of cell adhesion molecules (CAMs) and are comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. These molecules are primarily expressed in the nervous system. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, or spastic paraplegia type 1, that involves abnormalities of axonal growth.


Pssm-ID: 409367 [Multi-domain]  Cd Length: 89  Bit Score: 38.20  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982   33 VITPPGPEfVLNISSTFVLTCSGSA---PVMWEQMSQVPWQEAA----MNQDGTfssVLTLTNVTGGDTGEYFCVYNNSL 105
Cdd:cd04978     2 WIIEPPSL-VLSPGETGELICEAEGnpqPTITWRLNGVPIEPAPedmrRTVDGR---TLIFSNLQPNDTAVYQCNASNVH 77

                  ....
gi 226342982  106 GPEL 109
Cdd:cd04978    78 GYLL 81
STKc_PIM3 cd14102
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
805-953 2.74e-03

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3). PIM3 can inhibit apoptosis and promote cell survival and protein translation, therefore, it can enhance the proliferation of normal and cancer cells. Mice deficient with PIM3 show minimal effects, suggesting that PIM3 msy not be essential. Since its expression is enhanced in several cancers, it may make a good molecular target for cancer drugs. The PIM3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271004 [Multi-domain]  Cd Length: 253  Bit Score: 40.71  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  805 GFSYQVANGMDFLASKNCVHRDLAARNVLI--CEGKLvKICDFGlARDIMRDSNYISKGST--FLPLKWMApesiFNSLY 880
Cdd:cd14102   109 GFFRQVLEAVRHCYSCGVVHRDIKDENLLVdlRTGEL-KLIDFG-SGALLKDTVYTDFDGTrvYSPPEWIR----YHRYH 182
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226342982  881 TTLSDVWSFGILLWEIfTLGGTPYPElpmnDQfynAIKRGyRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQ 953
Cdd:cd14102   183 GRSATVWSLGVLLYDM-VCGDIPFEQ----DE---EILRG-RLYFRRRVSPECQQLIKWCLSLRPSDRPTLEQ 246
STKc_nPKC_epsilon cd05591
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon; STKs catalyze ...
806-917 2.99e-03

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-epsilon has been shown to behave as an oncoprotein. Its overexpression contributes to neoplastic transformation depending on the cell type. It contributes to oncogenesis by inducing disordered cell growth and inhibiting cell death. It also plays a role in tumor invasion and metastasis. PKC-epsilon has also been found to confer cardioprotection against ischemia and reperfusion-mediated damage. Other cellular functions include the regulation of gene expression, cell adhesion, and cell motility. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-epsilon subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270743 [Multi-domain]  Cd Length: 321  Bit Score: 40.94  E-value: 2.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYIskgSTF--LPlKWMAPESIFNSLYTTL 883
Cdd:cd05591   101 YAAEVTLALMFLHRHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGKTT---TTFcgTP-DYIAPEILQELEYGPS 176
                          90       100       110
                  ....*....|....*....|....*....|....
gi 226342982  884 SDVWSFGILLWEIftLGGTPYPELPMNDQFYNAI 917
Cdd:cd05591   177 VDWWALGVLMYEM--MAGQPPFEADNEDDLFESI 208
STKc_aPKC_iota cd05618
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota; STKs catalyze ...
806-904 3.62e-03

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270769 [Multi-domain]  Cd Length: 364  Bit Score: 40.79  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNyisKGSTFLPL-KWMAPESIFNSLYTTLS 884
Cdd:cd05618   126 YSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGD---TTSTFCGTpNYIAPEILRGEDYGFSV 202
                          90       100
                  ....*....|....*....|
gi 226342982  885 DVWSFGILLWEIFTlGGTPY 904
Cdd:cd05618   203 DWWALGVLMFEMMA-GRSPF 221
STKc_CRIK cd05601
Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase; STKs catalyze ...
823-906 3.97e-03

Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CRIK (also called citron kinase) is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger, and a pleckstrin homology (PH) domain, in addition to other motifs. The CRIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270752 [Multi-domain]  Cd Length: 328  Bit Score: 40.76  E-value: 3.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  823 VHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKgstfLPL---KWMAPE------SIFNSLYTTLSDVWSFGILL 893
Cdd:cd05601   124 VHRDIKPENILIDRTGHIKLADFGSAAKLSSDKTVTSK----MPVgtpDYIAPEvltsmnGGSKGTYGVECDWWSLGIVA 199
                          90
                  ....*....|...
gi 226342982  894 WEIFtLGGTPYPE 906
Cdd:cd05601   200 YEML-YGKTPFTE 211
PKc_DYRK4 cd14225
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
806-908 4.22e-03

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. DYRK4 is a testis-specific kinase with restricted expression to postmeiotic spermatids. It may function during spermiogenesis, however, it is not required for male fertility. DYRK4 has also been detected in a human teratocarcinoma cell line induced to produce postmitotic neurons. It may have a role in neuronal differentiation. DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. The DYRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271127 [Multi-domain]  Cd Length: 341  Bit Score: 40.84  E-value: 4.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  806 FSYQVANGMDFLASKNCVHRDLAARNVLICE-GKL-VKICDFGLA-RDIMRDSNYISkgSTFlplkWMAPESIFNSLYTT 882
Cdd:cd14225   151 FAISLLQCLRLLYRERIIHCDLKPENILLRQrGQSsIKVIDFGSScYEHQRVYTYIQ--SRF----YRSPEVILGLPYSM 224
                          90       100
                  ....*....|....*....|....*.
gi 226342982  883 LSDVWSFGILLWEIFtlggTPYPELP 908
Cdd:cd14225   225 AIDMWSLGCILAELY----TGYPLFP 246
STKc_CK1_delta_epsilon cd14125
Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon; ...
809-855 4.23e-03

Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK1 phosphorylates a variety of substrates including enzymes, transcription and splice factors, cytoskeletal proteins, viral oncogenes, receptors, and membrane-associated proteins. There are mutliple isoforms of CK1 and in mammals, seven isoforms (alpha, beta, gamma1-3, delta, and epsilon) have been characterized. These isoforms differ mainly in the length and structure of their C-terminal non-catalytic region. The delta and epsilon isoforms of CK1 play important roles in circadian rhythm and cell growth. They phosphorylate PERIOD proteins (PER1-3), which are circadian clock proteins that fulfill negative regulatory functions. PER phosphorylation leads to its degradation. However, CRY proteins form a complex with PER and CK1delta/epsilon that protects PER from degradation and leads to nuclear accummulation of the complex, which inhibits BMAL1-CLOCK dependent transcription activation. CK1delta/epsilon also phosphorylate the tumor suppressor p53 and the cellular oncogene Mdm2, which are key regulators of cell growth, genome integrity, and the development of cancer. This subfamily also includes the CK1 fungal proteins Saccharomyces cerevisiae HRR25 and Schizosaccharomyces pombe HHP1. These fungal proteins are involved in DNA repair. The CK1 delta/epsilon subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271027 [Multi-domain]  Cd Length: 275  Bit Score: 40.43  E-value: 4.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 226342982  809 QVANGMDFLASKNCVHRDLAARNVLICEGK---LVKICDFGLARDiMRDS 855
Cdd:cd14125   104 QMISRIEYVHSKNFIHRDIKPDNFLMGLGKkgnLVYIIDFGLAKK-YRDP 152
STKc_SGK1 cd05602
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
604-774 4.35e-03

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK1 is ubiquitously expressed and is under transcriptional control of numerous stimuli including cell stress (cell shrinkage), serum, hormones (gluco- and mineralocorticoids), gonadotropins, growth factors, interleukin-6, and other cytokines. It plays roles in sodium retention and potassium elimination in the kidney, nutrient transport, salt sensitivity, memory consolidation, and cardiac repolarization. A common SGK1 variant is associated with increased blood pressure and body weight. SGK1 may also contribute to tumor growth, neurodegeneration, fibrosing disease, and ischemia. The SGK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270753 [Multi-domain]  Cd Length: 339  Bit Score: 40.77  E-value: 4.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  604 RTLGSGAFGQVVEAtahglSHSQATMKVAVKMLKSTA--RSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIIT 681
Cdd:cd05602    13 KVIGKGSFGKVLLA-----RHKSDEKFYAVKVLQKKAilKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTTDKLYFVL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  682 EYCRYGDLVDYLHRNKhTFLQrhsnkhcpPSAELYSNALPVGFSLPSHLNLTgesdggYMDMsKDESIdyvpMLDMKGDI 761
Cdd:cd05602    88 DYINGGELFYHLQRER-CFLE--------PRARFYAAEIASALGYLHSLNIV------YRDL-KPENI----LLDSQGHI 147
                         170       180       190
                  ....*....|....*....|....*....|
gi 226342982  762 KYAD-------IE----------SPSYMAP 774
Cdd:cd05602   148 VLTDfglckenIEpngttstfcgTPEYLAP 177
STKc_CaMKI cd14083
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
597-691 5.70e-03

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270985 [Multi-domain]  Cd Length: 259  Bit Score: 40.05  E-value: 5.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226342982  597 RDQLVLGRTLGSGAFGQVVeatahgLSHSQATMK-VAVKMLKSTARSSEKQALMSELKIMSHLgPHLNVVNLLGACTKGG 675
Cdd:cd14083     2 RDKYEFKEVLGTGAFSEVV------LAEDKATGKlVAIKCIDKKALKGKEDSLENEIAVLRKI-KHPNIVQLLDIYESKS 74
                          90
                  ....*....|....*.
gi 226342982  676 PIYIITEYCRYGDLVD 691
Cdd:cd14083    75 HLYLVMELVTGGELFD 90
PKc_DYRK4 cd14225
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
605-658 9.90e-03

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. DYRK4 is a testis-specific kinase with restricted expression to postmeiotic spermatids. It may function during spermiogenesis, however, it is not required for male fertility. DYRK4 has also been detected in a human teratocarcinoma cell line induced to produce postmitotic neurons. It may have a role in neuronal differentiation. DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. The DYRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271127 [Multi-domain]  Cd Length: 341  Bit Score: 39.69  E-value: 9.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 226342982  605 TLGSGAFGQVVEAtahgLSHSQATMkVAVKMLKSTARsSEKQALMsELKIMSHL 658
Cdd:cd14225    50 VIGKGSFGQVVKA----LDHKTNEH-VAIKIIRNKKR-FHHQALV-EVKILDAL 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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