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Conserved domains on  [gi|226529917|ref|NP_001152759|]
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triosephosphate isomerase isoform 2 [Homo sapiens]

Protein Classification

triose-phosphate isomerase( domain architecture ID 10794370)

triose-phosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate

CATH:  3.20.20.70
EC:  5.3.1.1
Gene Ontology:  GO:0004807|GO:0006096|GO:0031625|GO:0042803
PubMed:  11257493|12206759

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 39-284 2.36e-137

triosephosphate isomerase; Provisional


:

Pssm-ID: 240365  Cd Length: 255  Bit Score: 387.73  E-value: 2.36e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  39 APSRKFFVGGNWKMNGRKQSLGELIGTLNAAKV-PADTEVVCAPPTAYIDFARQKLD-PKIAVAAQNCYKVTNGAFTGEI 116
Cdd:PTZ00333   1 MMKRKPFVGGNWKCNGTKASIKELIDSFNKLKFdPNNVDVVVAPPSLHIPLVQEKLKnKNFKISSQNVSLTGSGAFTGEI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 117 SPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKD-- 194
Cdd:PTZ00333  81 SAEMLKDLGINWTILGHSERRQYFGETNEIVAQKVKNALENGLKVILCIGETLEEREAGQTSDVLSKQLEAIVKKVSDea 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 195 WSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASL 274
Cdd:PTZ00333 161 WDNIVIAYEPVWAIGTGKVATPEQAQEVHAFIRKWLAEKVGADVAEATRIIYGGSVNEKNCKELIKQPDIDGFLVGGASL 240

                        250
                 ....*....|
gi 226529917 275 KPEFVDIINA 284
Cdd:PTZ00333 241 KPDFVDIIKS 250
 
Name Accession Description Interval E-value
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 39-284 2.36e-137

triosephosphate isomerase; Provisional


Pssm-ID: 240365  Cd Length: 255  Bit Score: 387.73  E-value: 2.36e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  39 APSRKFFVGGNWKMNGRKQSLGELIGTLNAAKV-PADTEVVCAPPTAYIDFARQKLD-PKIAVAAQNCYKVTNGAFTGEI 116
Cdd:PTZ00333   1 MMKRKPFVGGNWKCNGTKASIKELIDSFNKLKFdPNNVDVVVAPPSLHIPLVQEKLKnKNFKISSQNVSLTGSGAFTGEI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 117 SPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKD-- 194
Cdd:PTZ00333  81 SAEMLKDLGINWTILGHSERRQYFGETNEIVAQKVKNALENGLKVILCIGETLEEREAGQTSDVLSKQLEAIVKKVSDea 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 195 WSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASL 274
Cdd:PTZ00333 161 WDNIVIAYEPVWAIGTGKVATPEQAQEVHAFIRKWLAEKVGADVAEATRIIYGGSVNEKNCKELIKQPDIDGFLVGGASL 240

                        250
                 ....*....|
gi 226529917 275 KPEFVDIINA 284
Cdd:PTZ00333 241 KPDFVDIIKS 250
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 44-283 5.45e-130

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 368.79  E-value: 5.45e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  44 FFVGGNWKMNGRKQSLGELIGTLNAA-KVPADTEVVCAPPTAYIDFARQKL-DPKIAVAAQNCYKVTNGAFTGEISPGMI 121
Cdd:cd00311    1 PLVAGNWKMNGTLAEALELAKALNAVlKDESGVEVVVAPPFTYLAAVAEALeGSKIKVGAQNVSPEDSGAFTGEISAEML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 122 KDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLA 201
Cdd:cd00311   81 KDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGVEDLAPVVIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 202 YEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDaVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPE-FVD 280
Cdd:cd00311  161 YEPVWAIGTGKTASPEQAQEVHAFIRKLLAELYGE-VAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKAEsFLD 239


                 ...
gi 226529917 281 IIN 283
Cdd:cd00311  240 IIK 242
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 42-284 3.35e-120

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 343.96  E-value: 3.35e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  42 RKFFVGGNWKMNGRKQSLGELIGTL-NAAKVPADTEVVCAPPTAYIDFARQKL-DPKIAVAAQNCYKVTNGAFTGEISPG 119
Cdd:COG0149    2 RKPLIAGNWKMNGTLAEAKALLAALaAALADLADVEVVVCPPFTYLAAVAEALaGSPIALGAQNVHWEDSGAYTGEISAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 120 MIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTK-VIAD-NVKDWSK 197
Cdd:COG0149   82 MLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKaALAGlSAEQAAN 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 198 VVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPE 277
Cdd:COG0149  162 VVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGASLDAE 241


                 ....*...
gi 226529917 278 -FVDIINA 284
Cdd:COG0149  242 dFLAIVRA 249
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 44-284 1.08e-119

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 342.57  E-value: 1.08e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917   44 FFVGGNWKMNGRKQSLGELIGTLNAAKVPA-DTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIK 122
Cdd:pfam00121   1 PIIAGNWKMNGTLAEAAELLAELAEALADEsGVEVVVAPPFTYLSAVAELLGSNIKVGAQNVDPEESGAFTGEISAEMLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  123 DCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDW-SKVVLA 201
Cdd:pfam00121  81 DLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAEqKNLVIA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  202 YEPVWAIGTGKTATPQQAQEVHEKLRGWLkSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPE-FVD 280
Cdd:pfam00121 161 YEPVWAIGTGKTATPEQAQEVHAFIRAVL-AELYKEVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLKAEdFLD 239


                  ....
gi 226529917  281 IINA 284
Cdd:pfam00121 240 IINA 243
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 45-277 6.81e-63

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 196.95  E-value: 6.81e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917   45 FVGGNWKM-NGRKQSLGELIGTLNA-AKVPADTEVVCAPPTAYIDFARQKLdpKIAVAAQNCYKVTNGAFTGEISPGMIK 122
Cdd:TIGR00419   1 LVIGNWKTyNESRGMRALEVAKIAEeVASEAGVAVAVAPPFVDLPMIKREV--EIPVYAQHVDAVLSGAHTGEISAEMLK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  123 DCGATWVVLGHSERRHVfgESDelIGQKVAHALAEGLGVIACIgekldereagiteKVVFEQTKVIAdnvkdWSKVVLAY 202
Cdd:TIGR00419  79 DIGAKGTLINHSERRMK--LAD--IEKKIARLKELGLTSVVCT-------------NNVLTTAAAAA-----LEPDVVAV 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226529917  203 EPVWAIGTGKTATPQQAQEVHEKLRgwlksnVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPE 277
Cdd:TIGR00419 137 EPPELIGTGIPVSPAQPEVVHGSVR------AVKEVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSLKAD 205
 
Name Accession Description Interval E-value
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 39-284 2.36e-137

triosephosphate isomerase; Provisional


Pssm-ID: 240365  Cd Length: 255  Bit Score: 387.73  E-value: 2.36e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  39 APSRKFFVGGNWKMNGRKQSLGELIGTLNAAKV-PADTEVVCAPPTAYIDFARQKLD-PKIAVAAQNCYKVTNGAFTGEI 116
Cdd:PTZ00333   1 MMKRKPFVGGNWKCNGTKASIKELIDSFNKLKFdPNNVDVVVAPPSLHIPLVQEKLKnKNFKISSQNVSLTGSGAFTGEI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 117 SPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKD-- 194
Cdd:PTZ00333  81 SAEMLKDLGINWTILGHSERRQYFGETNEIVAQKVKNALENGLKVILCIGETLEEREAGQTSDVLSKQLEAIVKKVSDea 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 195 WSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASL 274
Cdd:PTZ00333 161 WDNIVIAYEPVWAIGTGKVATPEQAQEVHAFIRKWLAEKVGADVAEATRIIYGGSVNEKNCKELIKQPDIDGFLVGGASL 240

                        250
                 ....*....|
gi 226529917 275 KPEFVDIINA 284
Cdd:PTZ00333 241 KPDFVDIIKS 250
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 44-283 5.45e-130

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 368.79  E-value: 5.45e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  44 FFVGGNWKMNGRKQSLGELIGTLNAA-KVPADTEVVCAPPTAYIDFARQKL-DPKIAVAAQNCYKVTNGAFTGEISPGMI 121
Cdd:cd00311    1 PLVAGNWKMNGTLAEALELAKALNAVlKDESGVEVVVAPPFTYLAAVAEALeGSKIKVGAQNVSPEDSGAFTGEISAEML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 122 KDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLA 201
Cdd:cd00311   81 KDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGVEDLAPVVIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 202 YEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDaVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPE-FVD 280
Cdd:cd00311  161 YEPVWAIGTGKTASPEQAQEVHAFIRKLLAELYGE-VAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKAEsFLD 239


                 ...
gi 226529917 281 IIN 283
Cdd:cd00311  240 IIK 242
PLN02561 PLN02561
triosephosphate isomerase
 41-284 1.00e-124

triosephosphate isomerase


Pssm-ID: 178175  Cd Length: 253  Bit Score: 355.67  E-value: 1.00e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  41 SRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPA--DTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISP 118
Cdd:PLN02561   2 ARKFFVGGNWKCNGTVEEVKKIVTTLNEAEVPSedVVEVVVSPPFVFLPLVKSLLRPDFQVAAQNCWVKKGGAFTGEISA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 119 GMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKV 198
Cdd:PLN02561  82 EMLVNLGIPWVILGHSERRALLGESNEFVGDKVAYALSQGLKVIACVGETLEQRESGSTMDVVAAQTKAIADKVSDWANV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 199 VLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEF 278
Cdd:PLN02561 162 VLAYEPVWAIGTGKVATPAQAQEVHDELRKWLHKNVSPEVAATTRIIYGGSVTGANCKELAAQPDVDGFLVGGASLKPEF 241


                 ....*.
gi 226529917 279 VDIINA 284
Cdd:PLN02561 242 IDIIKS 247
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 42-284 3.35e-120

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 343.96  E-value: 3.35e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  42 RKFFVGGNWKMNGRKQSLGELIGTL-NAAKVPADTEVVCAPPTAYIDFARQKL-DPKIAVAAQNCYKVTNGAFTGEISPG 119
Cdd:COG0149    2 RKPLIAGNWKMNGTLAEAKALLAALaAALADLADVEVVVCPPFTYLAAVAEALaGSPIALGAQNVHWEDSGAYTGEISAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 120 MIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTK-VIAD-NVKDWSK 197
Cdd:COG0149   82 MLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKaALAGlSAEQAAN 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 198 VVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPE 277
Cdd:COG0149  162 VVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGASLDAE 241


                 ....*...
gi 226529917 278 -FVDIINA 284
Cdd:COG0149  242 dFLAIVRA 249
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 44-284 1.08e-119

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 342.57  E-value: 1.08e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917   44 FFVGGNWKMNGRKQSLGELIGTLNAAKVPA-DTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIK 122
Cdd:pfam00121   1 PIIAGNWKMNGTLAEAAELLAELAEALADEsGVEVVVAPPFTYLSAVAELLGSNIKVGAQNVDPEESGAFTGEISAEMLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  123 DCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDW-SKVVLA 201
Cdd:pfam00121  81 DLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAEqKNLVIA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  202 YEPVWAIGTGKTATPQQAQEVHEKLRGWLkSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPE-FVD 280
Cdd:pfam00121 161 YEPVWAIGTGKTATPEQAQEVHAFIRAVL-AELYKEVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLKAEdFLD 239


                  ....
gi 226529917  281 IINA 284
Cdd:pfam00121 240 IINA 243
tpiA PRK00042
triosephosphate isomerase; Provisional
 42-284 3.72e-115

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 331.31  E-value: 3.72e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  42 RKFFVGGNWKMNGRKQSLGELIGTLNAA-KVPADTEVVCAPPTAYIDFARQKLDP-KIAVAAQNCYKVTNGAFTGEISPG 119
Cdd:PRK00042   1 RKPIIAGNWKMNKTLAEAKALVEELKAAlPDADGVEVAVAPPFTALASVKEALKGsNIKLGAQNVHPEDSGAFTGEISAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 120 MIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNV--KDWSK 197
Cdd:PRK00042  81 MLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLsaEQFAN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 198 VVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDaVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPE 277
Cdd:PRK00042 161 LVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYGE-VAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGASLKAE 239


                 ....*...
gi 226529917 278 -FVDIINA 284
Cdd:PRK00042 240 dFLAIVKA 247
PLN02429 PLN02429
triosephosphate isomerase
 34-284 9.35e-100

triosephosphate isomerase


Pssm-ID: 166070  Cd Length: 315  Bit Score: 294.78  E-value: 9.35e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  34 GSSAMAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFT 113
Cdd:PLN02429  56 GVVAMAGSGKFFVGGNWKCNGTKDSIAKLISDLNSATLEADVDVVVSPPFVYIDQVKSSLTDRIDISGQNSWVGKGGAFT 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 114 GEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVK 193
Cdd:PLN02429 136 GEISVEQLKDLGCKWVILGHSERRHVIGEKDEFIGKKAAYALSEGLGVIACIGEKLEEREAGKTFDVCFAQLKAFADAVP 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 194 DWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGAS 273
Cdd:PLN02429 216 SWDNIVVAYEPVWAIGTGKVASPQQAQEVHVAVRGWLKKNVSEEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGAS 295

                        250
                 ....*....|..
gi 226529917 274 LK-PEFVDIINA 284
Cdd:PLN02429 296 LKgPEFATIVNS 307
PRK13962 PRK13962
bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional
 30-284 2.92e-83

bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional


Pssm-ID: 237572 [Multi-domain]  Cd Length: 645  Bit Score: 262.74  E-value: 2.92e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  30 LQRLGSSAMAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLD-PKIAVAAQNCYKVT 108
Cdd:PRK13962 385 LPGIACLLDKNPRKPIIAGNWKMNKTPAEAKEFVNELKKYVKDAQAEVVVCPPFTALPSVKEAVDgSNIKLGAQNVFYEE 464

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 109 NGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTK-- 186
Cdd:PRK13962 465 KGAYTGEISGPMLAEIGVEYVIIGHSERRQYFGETDELVNKKVLAALKAGLTPILCVGETLDERESGITFDVVRLQLKaa 544

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 187 ---VIADNVKdwsKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPD 263
Cdd:PRK13962 545 lngLSAEQVK---KVVIAYEPVWAIGTGKVATPEQAQEVHAFIRKLVAELYGEEAARKVRILYGGSVKSENAAGLFNQPD 621

                        250       260
                 ....*....|....*....|..
gi 226529917 264 VDGFLVGGASLKP-EFVDIINA 284
Cdd:PRK13962 622 IDGGLVGGASLKAqEFAAIANY 643
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 45-277 6.81e-63

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 196.95  E-value: 6.81e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917   45 FVGGNWKM-NGRKQSLGELIGTLNA-AKVPADTEVVCAPPTAYIDFARQKLdpKIAVAAQNCYKVTNGAFTGEISPGMIK 122
Cdd:TIGR00419   1 LVIGNWKTyNESRGMRALEVAKIAEeVASEAGVAVAVAPPFVDLPMIKREV--EIPVYAQHVDAVLSGAHTGEISAEMLK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  123 DCGATWVVLGHSERRHVfgESDelIGQKVAHALAEGLGVIACIgekldereagiteKVVFEQTKVIAdnvkdWSKVVLAY 202
Cdd:TIGR00419  79 DIGAKGTLINHSERRMK--LAD--IEKKIARLKELGLTSVVCT-------------NNVLTTAAAAA-----LEPDVVAV 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226529917  203 EPVWAIGTGKTATPQQAQEVHEKLRgwlksnVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPE 277
Cdd:TIGR00419 137 EPPELIGTGIPVSPAQPEVVHGSVR------AVKEVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSLKAD 205
PRK14565 PRK14565
triosephosphate isomerase; Provisional
 44-282 3.65e-56

triosephosphate isomerase; Provisional


Pssm-ID: 237758  Cd Length: 237  Bit Score: 180.72  E-value: 3.65e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  44 FFVGGNWKMNGRKQSLGELIGTLNA--AKVPADTEVVCAPP----TAYIDfarqkLDPKIAVAAQNCYKVTNGAFTGEIS 117
Cdd:PRK14565   3 FLIVANWKMNGDFSLFSSFLKELSNklANNEITLKLVICPPftamSSFVE-----CNPNIKLGAQNCFYGSSGGYTGEIS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 118 PGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKviaDNVKDWSK 197
Cdd:PRK14565  78 AKMLKECGCSYVILGHSERRSTFHETDSDIRLKAESAIESGLIPIICVGETLEDRENGMTKDVLLEQCS---NCLPKHGE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 198 VVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWlkSNVSDavaqstrIIYGGSVTGATCKELASQPDVDGFLVGGASLKPE 277
Cdd:PRK14565 155 FIIAYEPVWAIGGSTIPSNDAIAEAFEIIRSY--DSKSH-------IIYGGSVNQENIRDLKSINQLSGVLVGSASLDVD 225


                 ....*.
gi 226529917 278 -FVDII 282
Cdd:PRK14565 226 sFCKII 231
PRK14905 PRK14905
triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; ...
 41-270 2.79e-40

triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional


Pssm-ID: 184898 [Multi-domain]  Cd Length: 355  Bit Score: 143.25  E-value: 2.79e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  41 SRKFFVGGNWKM---NGRK-QSLGELIGTLNAAKVPADTEVVCAPptAYIDF-------ARQKLDPKIAVAAQNCYKVTN 109
Cdd:PRK14905   2 AKKIYFGTNLKMykgNAETvDYLSELLAFAEKFKSDYDIELFVIP--SYIALkdaveaaASETGHPKIKIGAQNMNAKDK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 110 GAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIA 189
Cdd:PRK14905  80 GQFTGEISPLMLKELGIELVMIGHSERRHVLKETDQEENEKVLAALKHGFITLLCIGETLEQKNYNISDEVLRTQLKIGL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 190 DNV--KDWSKVVLAYEPVWAIGTGKT-ATPQQAQEVHEKLRGWLKSNVSDAvAQSTRIIYGGSVTGATCKELASQPDVDG 266
Cdd:PRK14905 160 HGVsaEQLPHLFIAYEPVWAIGEGGIpASAEYADEKHAIIKQCLFELFAEE-SKKIPVLYGGSVNLENANELIMKPHIDG 238


                 ....
gi 226529917 267 FLVG 270
Cdd:PRK14905 239 LFIG 242
PRK15492 PRK15492
triosephosphate isomerase; Provisional
 41-270 7.72e-40

triosephosphate isomerase; Provisional


Pssm-ID: 185389  Cd Length: 260  Bit Score: 139.36  E-value: 7.72e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  41 SRKFFVGGNWKM-NGRKQS------LGELIGTLNAAKvpaDTEVVCAPPTAYIDFARQKL-----DPKIAVAAQNCYKVT 108
Cdd:PRK15492   1 MKKIYFGTNLKMyKGIADAtdflakLSELADDIPADK---DIELFVIPSFTAIQDAIAATlaiphDHPIIIGAQNMNPND 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 109 NGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKV- 187
Cdd:PRK15492  78 NGQFTGDISPLMLKEIGTQLVMIGHSERRHKFGETDQEENAKVLAALKHDFTTLLCVGETLEQKNYGISDEILRTQLKIg 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917 188 -IADNVKDWSKVVLAYEPVWAIGT-GKTATPQQAQEVHEKLRGWLKSNVSDAvAQSTRIIYGGSVTGATCKELASQPDVD 265
Cdd:PRK15492 158 lHGINPDQLAKLRIAYEPVWAIGEaGIPASADYADEKHAVIKQCLIELFGDA-GDDIPVFYGGSVNAENANELFGQPHID 236


                 ....*
gi 226529917 266 GFLVG 270
Cdd:PRK15492 237 GLFIG 241
PRK04302 PRK04302
triosephosphate isomerase; Provisional
 68-164 2.29e-09

triosephosphate isomerase; Provisional


Pssm-ID: 235274  Cd Length: 223  Bit Score: 56.41  E-value: 2.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226529917  68 AAKVPADTEV--VCAPPTAYIDFARQKLDpkIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGEsde 145
Cdd:PRK04302  28 AEKVSKETGVriAVAPQALDIRRVAEEVD--IPVYAQHVDPVEPGSHTGHILPEAVKDAGAVGTLINHSERRLTLAD--- 102

                         90
                 ....*....|....*....
gi 226529917 146 lIGQKVAHALAEGLGVIAC 164
Cdd:PRK04302 103 -IEAVVERAKKLGLESVVC 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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