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Conserved domains on  [gi|229577236|ref|NP_001153198|]
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translocator protein 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TspO_MBR pfam03073
TspO/MBR family; Tryptophan-rich sensory protein (TspO) is an integral membrane protein that ...
 8-154 5.76e-19

TspO/MBR family; Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light. It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates. In, the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.


:

Pssm-ID: 460795  Cd Length: 144  Bit Score: 78.40  E-value: 5.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577236    8 FVLLPHLGPILVWLFTRDHMSGWCEGPRMLSWCPFYKVLLLVQTAIYSVVGYASYLVWKDLGGGlgwPLALPLGLYAVQL 87
Cdd:pfam03073   1 AVALPLAVGLLGGLFTRSSISDWYASLKKPPWTPPNWVFPPVWTVLYILMGIAAYLVWRAGGGS---GRKLALGLYGLQL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 229577236   88 TISWTVLVLFFTVHNPGLALLHLLLLYGLVVSTALIWHPINKLAALLLLPYLAWLTVTSALTYHLWR 154
Cdd:pfam03073  78 ALNLLWSPLFFGLRSPGLALVDILALWGLVLATILAFYRISKLAALLLVPYLLWLSFATYLNYGIWL 144
 
Name Accession Description Interval E-value
TspO_MBR pfam03073
TspO/MBR family; Tryptophan-rich sensory protein (TspO) is an integral membrane protein that ...
 8-154 5.76e-19

TspO/MBR family; Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light. It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates. In, the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.


Pssm-ID: 460795  Cd Length: 144  Bit Score: 78.40  E-value: 5.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577236    8 FVLLPHLGPILVWLFTRDHMSGWCEGPRMLSWCPFYKVLLLVQTAIYSVVGYASYLVWKDLGGGlgwPLALPLGLYAVQL 87
Cdd:pfam03073   1 AVALPLAVGLLGGLFTRSSISDWYASLKKPPWTPPNWVFPPVWTVLYILMGIAAYLVWRAGGGS---GRKLALGLYGLQL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 229577236   88 TISWTVLVLFFTVHNPGLALLHLLLLYGLVVSTALIWHPINKLAALLLLPYLAWLTVTSALTYHLWR 154
Cdd:pfam03073  78 ALNLLWSPLFFGLRSPGLALVDILALWGLVLATILAFYRISKLAALLLVPYLLWLSFATYLNYGIWL 144
TSPO_MBR cd15904
Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family; This family ...
 9-153 2.75e-08

Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family; This family contains tryptophan-rich translocator protein (TSPO), an integral membrane protein that is highly conserved from bacteria to mammals. In eukaryotes, it is mainly found in the outer mitochondrial membranes of steroid-synthesizing cells of the nervous system where it transports cholesterol into mitochondria. It is known to be highly expressed in metastatic cancer, steriodogenic tissues, as well as inflammatory and neurological diseases such as Alzheimer's and Parkinson's. TSPO is also known as the peripheral benzodiazepine receptor (MBR) and its ligands include benzodiazepine drugs, implicated in regulating apoptosis. In human, a single polymorphism A147T is associated with psychiatric disorders; the mutation causes structural changes in a region implicated in cholesterol binding. TSPO is homologous to bacterial tryptophan-rich sensory proteins, and their tryptophan residues are believed to be functionally important. In bacteria, TSPO acts as a negative regulator of expression of specific photosynthesis genes in response to oxygen/light; it catalyzes a photooxidative degradation of Proto porphyrine (PpIX). R. sphaeroides TSPO (RsTSPO) is involved in porphyrin transport, similar to human, while Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism.


Pssm-ID: 320706  Cd Length: 142  Bit Score: 50.19  E-value: 2.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577236   9 VLLPHLGPILVWLFTRDHMSGWCEGPRMLSWCPFYKVLLLVQTAIYSVVGYASYLVWKDLGGGLGWplaLPLGLYAVQLT 88
Cdd:cd15904    1 LALALAVGLLGGLLTGSSIGEWYASLNKPSWTPPNWVFGPVWTILYILMGIAAYLVWRAGGFAGRK---LALALYAVQLA 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 229577236  89 ISWTVLVLFFTVHNPGLALLHLLLLYGLVVSTALIWHPINKLAALLLLPYLAWLTVTSALTYHLW 153
Cdd:cd15904   78 LNLLWSPLFFGLHRPGLALVVILALWLLILATIVAFWRVSRLAALLLLPYLAWVSFATYLNYSIW 142
 
Name Accession Description Interval E-value
TspO_MBR pfam03073
TspO/MBR family; Tryptophan-rich sensory protein (TspO) is an integral membrane protein that ...
 8-154 5.76e-19

TspO/MBR family; Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light. It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates. In, the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.


Pssm-ID: 460795  Cd Length: 144  Bit Score: 78.40  E-value: 5.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577236    8 FVLLPHLGPILVWLFTRDHMSGWCEGPRMLSWCPFYKVLLLVQTAIYSVVGYASYLVWKDLGGGlgwPLALPLGLYAVQL 87
Cdd:pfam03073   1 AVALPLAVGLLGGLFTRSSISDWYASLKKPPWTPPNWVFPPVWTVLYILMGIAAYLVWRAGGGS---GRKLALGLYGLQL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 229577236   88 TISWTVLVLFFTVHNPGLALLHLLLLYGLVVSTALIWHPINKLAALLLLPYLAWLTVTSALTYHLWR 154
Cdd:pfam03073  78 ALNLLWSPLFFGLRSPGLALVDILALWGLVLATILAFYRISKLAALLLVPYLLWLSFATYLNYGIWL 144
TSPO_MBR cd15904
Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family; This family ...
 9-153 2.75e-08

Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family; This family contains tryptophan-rich translocator protein (TSPO), an integral membrane protein that is highly conserved from bacteria to mammals. In eukaryotes, it is mainly found in the outer mitochondrial membranes of steroid-synthesizing cells of the nervous system where it transports cholesterol into mitochondria. It is known to be highly expressed in metastatic cancer, steriodogenic tissues, as well as inflammatory and neurological diseases such as Alzheimer's and Parkinson's. TSPO is also known as the peripheral benzodiazepine receptor (MBR) and its ligands include benzodiazepine drugs, implicated in regulating apoptosis. In human, a single polymorphism A147T is associated with psychiatric disorders; the mutation causes structural changes in a region implicated in cholesterol binding. TSPO is homologous to bacterial tryptophan-rich sensory proteins, and their tryptophan residues are believed to be functionally important. In bacteria, TSPO acts as a negative regulator of expression of specific photosynthesis genes in response to oxygen/light; it catalyzes a photooxidative degradation of Proto porphyrine (PpIX). R. sphaeroides TSPO (RsTSPO) is involved in porphyrin transport, similar to human, while Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism.


Pssm-ID: 320706  Cd Length: 142  Bit Score: 50.19  E-value: 2.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229577236   9 VLLPHLGPILVWLFTRDHMSGWCEGPRMLSWCPFYKVLLLVQTAIYSVVGYASYLVWKDLGGGLGWplaLPLGLYAVQLT 88
Cdd:cd15904    1 LALALAVGLLGGLLTGSSIGEWYASLNKPSWTPPNWVFGPVWTILYILMGIAAYLVWRAGGFAGRK---LALALYAVQLA 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 229577236  89 ISWTVLVLFFTVHNPGLALLHLLLLYGLVVSTALIWHPINKLAALLLLPYLAWLTVTSALTYHLW 153
Cdd:cd15904   78 LNLLWSPLFFGLHRPGLALVVILALWLLILATIVAFWRVSRLAALLLLPYLAWVSFATYLNYSIW 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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