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Conserved domains on  [gi|1214146097|ref|NP_001153650|]
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kelch domain-containing protein 7B [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 887-962 4.46e-27

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18484:

Pssm-ID: 475122  Cd Length: 77  Bit Score: 105.54  E-value: 4.46e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1214146097  887 LDLGSCLEVLAFAQQHGELGLAQETYVLMSNNLLHVLGDPHLYRQLSGADRERILNLRTCQGQTVLGVLVLPSLYQ 962
Cdd:cd18484      1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLEAGRACLVVAELNDVFE 76
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
991-1214 2.59e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 110.25  E-value: 2.59e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  991 LHVFNPQENVWWPLTQVPEEvPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNKVFCYNPLTNIWSQIRPMQQARAQLKLV 1070
Cdd:COG3055     40 FEVYDPATNTWSELAPLPGP-PRHHAAAVAQDGKLYVFGGFTGANPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATAL 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097 1071 ALDGMLYAIGGE----CLYSMERYDPRTDTWTLRASLPEGTFPVAhEAVVCRGEIYVTGGhlfyrlLRYSPMKDSWDECP 1146
Cdd:COG3055    119 LLDGKIYVVGGWddggNVAWVEVYDPATGTWTQLAPLPTPRDHLA-AAVLPDGKILVIGG------RNGSGFSNTWTTLA 191

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1214146097 1147 YSASHRRSSDMVALGGFLYRFDLLRGVGAAVMRYNTVTGSWSRAASLplsdPAPLHCTV---LGNTIYCLN 1214
Cdd:COG3055    192 PLPTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGEL----PTPRHGHAavlTDGKVYVIG 258
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 427-786 2.03e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 62.65  E-value: 2.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  427 RPAAEQSFAPIMDTRKSThglsstPSDTLPASAPTRDTELVPSSttavhPSPGFLHTVSTSAPLDNLPLDVSQGPSggds 506
Cdd:PHA03247  2685 RRAARPTVGSLTSLADPP------PPPPTPEPAPHALVSATPLP-----PGPAAARQASPALPAAPAPPAVPAGPA---- 2749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  507 LRVGPAPLPTPTLTSAGASTSAPTVilaslPVSPPASTAASPLTSPApgtaaptstSTATPSLTLPLCPAPVTALTTTST 586
Cdd:PHA03247  2750 TPGGPARPARPPTTAGPPAPAPPAA-----PAAGPPRRLTRPAVASL---------SESRESLPSPWDPADPPAAVLAPA 2815

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  587 PtpsptpatalTLISSANPPPTSPPALASAPVAAQDPvadTEPRPKNTESNVGLSKSSPERRISNSWGNLITMVLRSHPF 666
Cdd:PHA03247  2816 A----------ALPPAASPAGPLPPPTSAQPTAPPPP---PGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPP 2882

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  667 PRQEKAQGSAPRADPESPAGPSPSTYSEDIQPGSSSEGAIFSLQDKHRPVLVTAVGSESLAEARCETQPVSLETNAslTP 746
Cdd:PHA03247  2883 VRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGA--VP 2960

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1214146097  747 DPRgdetkqksLDLLPPAAEPVASPQVPVSAQPGPVPPTS 786
Cdd:PHA03247  2961 QPW--------LGALVPGRVAVPRFRVPQPAPSREAPASS 2992
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 274-565 1.34e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 1.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  274 NLTSSLSAGPSLHHADkgLKAPQEMGLADAVDSRPQADSFKDVCGRSSlrlPPTSTAGSGAKGAESKETGSPSPRETRSi 353
Cdd:pfam05109  457 NLTAPASTGPTVSTAD--VTSPTPAGTTSGASPVTPSPSPRDNGTESK---APDMTSPTSAVTTPTPNATSPTPAVTTP- 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  354 laSKEARSREGGAGVVTSNVS-PSQGALpeelhSEACTVDQVAGQSKMEKLGeghlngKGRGSCQGKESKDVAGRPAAEQ 432
Cdd:pfam05109  531 --TPNATSPTLGKTSPTSAVTtPTPNAT-----SPTPAVTTPTPNATIPTLG------KTSPTSAVTTPTPNATSPTVGE 597

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  433 SFAPIMDTRKSTHGLSSTPSDTLP-----ASAPTRDTELVPSSTTAVHPSPGFLHTVSTSAPLDN----LPLDVSQGPSG 503
Cdd:pfam05109  598 TSPQANTTNHTLGGTSSTPVVTSPpknatSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNstshMPLLTSAHPTG 677

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1214146097  504 GDSLR--------------VGPAPLPTPTLTSAGASTSAPTVILASLPVSP--PASTAASPLTSPAPGTAAPTSTSTA 565
Cdd:pfam05109  678 GENITqvtpaststhhvstSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKgtPPKNATSPQAPSGQKTAVPTVTSTG 755
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
733-844 8.67e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14971:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 614  Bit Score: 40.14  E-value: 8.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  733 TQPVSlETNASLTPDPRGdETKQKSLDLLPPAAEPVASPQV---PVSAQPG---PVPPTSMRQDAQPTPQPRQRRRKRSI 806
Cdd:PRK14971   384 TQPAA-APQPSAAAAASP-SPSQSSAAAQPSAPQSATQPAGtppTVSVDPPaavPVNPPSTAPQAVRPAQFKEEKKIPVS 461

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1214146097  807 AQSSEHILIQEVPQQPQGQVR---KEGARPTDcRDILTEKQ 844
Cdd:PRK14971   462 KVSSLGPSTLRPIQEKAEQATgniKEAPTGTQ-KEIFTEED 501
 
Name Accession Description Interval E-value
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 887-962 4.46e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 105.54  E-value: 4.46e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1214146097  887 LDLGSCLEVLAFAQQHGELGLAQETYVLMSNNLLHVLGDPHLYRQLSGADRERILNLRTCQGQTVLGVLVLPSLYQ 962
Cdd:cd18484      1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLEAGRACLVVAELNDVFE 76
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
991-1214 2.59e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 110.25  E-value: 2.59e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  991 LHVFNPQENVWWPLTQVPEEvPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNKVFCYNPLTNIWSQIRPMQQARAQLKLV 1070
Cdd:COG3055     40 FEVYDPATNTWSELAPLPGP-PRHHAAAVAQDGKLYVFGGFTGANPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATAL 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097 1071 ALDGMLYAIGGE----CLYSMERYDPRTDTWTLRASLPEGTFPVAhEAVVCRGEIYVTGGhlfyrlLRYSPMKDSWDECP 1146
Cdd:COG3055    119 LLDGKIYVVGGWddggNVAWVEVYDPATGTWTQLAPLPTPRDHLA-AAVLPDGKILVIGG------RNGSGFSNTWTTLA 191

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1214146097 1147 YSASHRRSSDMVALGGFLYRFDLLRGVGAAVMRYNTVTGSWSRAASLplsdPAPLHCTV---LGNTIYCLN 1214
Cdd:COG3055    192 PLPTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGEL----PTPRHGHAavlTDGKVYVIG 258
PHA03098 PHA03098
kelch-like protein; Provisional
 1010-1211 1.01e-11

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 69.03  E-value: 1.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097 1010 EVPLRGCGLC-TMHNYLFLAGGIRGSGakaVCSNKVFCYNPLTNIWSQIRPMQQARAQLKLVALDGMLYAIGG----ECL 1084
Cdd:PHA03098   281 DIHYVYCFGSvVLNNVIYFIGGMNKNN---LSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsISL 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097 1085 YSMERYDPRTDTWTLRASLPEGTFPVAheAVVCRGEIYVTGGHLFYRLL-----RYSPMKDSWDEC-PYSASHRRSSdMV 1158
Cdd:PHA03098   358 NTVESWKPGESKWREEPPLIFPRYNPC--VVNVNNLIYVIGGISKNDELlktveCFSLNTNKWSKGsPLPISHYGGC-AI 434

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1214146097 1159 ALGGFLY-----RFDLLRGVGAAVMRYNTVTGSWSRAASLPLSDPAPLHCtVLGNTIY 1211
Cdd:PHA03098   435 YHDGKIYviggiSYIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLC-IFNNKIY 491
PHA03247 PHA03247
large tegument protein UL36; Provisional
 427-786 2.03e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 62.65  E-value: 2.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  427 RPAAEQSFAPIMDTRKSThglsstPSDTLPASAPTRDTELVPSSttavhPSPGFLHTVSTSAPLDNLPLDVSQGPSggds 506
Cdd:PHA03247  2685 RRAARPTVGSLTSLADPP------PPPPTPEPAPHALVSATPLP-----PGPAAARQASPALPAAPAPPAVPAGPA---- 2749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  507 LRVGPAPLPTPTLTSAGASTSAPTVilaslPVSPPASTAASPLTSPApgtaaptstSTATPSLTLPLCPAPVTALTTTST 586
Cdd:PHA03247  2750 TPGGPARPARPPTTAGPPAPAPPAA-----PAAGPPRRLTRPAVASL---------SESRESLPSPWDPADPPAAVLAPA 2815

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  587 PtpsptpatalTLISSANPPPTSPPALASAPVAAQDPvadTEPRPKNTESNVGLSKSSPERRISNSWGNLITMVLRSHPF 666
Cdd:PHA03247  2816 A----------ALPPAASPAGPLPPPTSAQPTAPPPP---PGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPP 2882

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  667 PRQEKAQGSAPRADPESPAGPSPSTYSEDIQPGSSSEGAIFSLQDKHRPVLVTAVGSESLAEARCETQPVSLETNAslTP 746
Cdd:PHA03247  2883 VRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGA--VP 2960

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1214146097  747 DPRgdetkqksLDLLPPAAEPVASPQVPVSAQPGPVPPTS 786
Cdd:PHA03247  2961 QPW--------LGALVPGRVAVPRFRVPQPAPSREAPASS 2992
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 1012-1061 1.45e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 48.76  E-value: 1.45e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1214146097 1012 PLRGCGLCTMHNYLFLAGGIRGSgakaVCSNKVFCYNPLTNIWSQIRPMQ 1061
Cdd:pfam01344    1 RRSGAGVVVVGGKIYVIGGFDGN----QSLNSVEVYDPETNTWSKLPSMP 46
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 443-786 1.79e-07

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 55.69  E-value: 1.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  443 STHGLSSTPSDTLPASAPTRDTE--LVPSSTTAVHPS---PGFLHTVSTSAPLDNLPLDVSQGPSGGDSlrvGPAPL-PT 516
Cdd:pfam05109  415 TTHKVIFSKAPESTTTSPTLNTTgfAAPNTTTGLPSSthvPTNLTAPASTGPTVSTADVTSPTPAGTTS---GASPVtPS 491

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  517 PTLTSAGASTSAPTVILASLPVSPPASTAASP---LTSPAPGTAAPTSTSTA-TPSLTLPL----CPAPVTALTTTSTPT 588
Cdd:pfam05109  492 PSPRDNGTESKAPDMTSPTSAVTTPTPNATSPtpaVTTPTPNATSPTLGKTSpTSAVTTPTpnatSPTPAVTTPTPNATI 571

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  589 PSPTPATALTLISSANPPPTSPPALASAPVA----------AQDPVADTEPR-------------PKNTESNVGLSKSSP 645
Cdd:pfam05109  572 PTLGKTSPTSAVTTPTPNATSPTVGETSPQAnttnhtlggtSSTPVVTSPPKnatsavttgqhniTSSSTSSMSLRPSSI 651

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  646 ERRISNSWGNLIT----MVLRSHP-----FPRQEKAQGSAPRADPESPAgPSPSTYSEDIQPGSSSEGA----------- 705
Cdd:pfam05109  652 SETLSPSTSDNSTshmpLLTSAHPtggenITQVTPASTSTHHVSTSSPA-PRPGTTSQASGPGNSSTSTkpgevnvtkgt 730

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  706 ---------IFSLQDKHRPVLVTAVGSESLAEARCETQPVSLETNASLTPDPRGD----ETKQKSLDLLPPAAEP----- 767
Cdd:pfam05109  731 ppknatspqAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDsttpRTRYNATTYLPPSTSSklrpr 810

                          410       420
                   ....*....|....*....|.
gi 1214146097  768 --VASPQVPVSAQPGPVPPTS 786
Cdd:pfam05109  811 wtFTSPPVTTAQATVPVPPTS 831
Kelch smart00612
Kelch domain;
1076-1119 5.28e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.47  E-value: 5.28e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 1214146097  1076 LYAIGG----ECLYSMERYDPRTDTWTLRASLPEGTFPVAheAVVCRG 1119
Cdd:smart00612    2 IYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPTPRSGHG--VAVING 47
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
457-612 6.22e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 43.97  E-value: 6.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  457 ASAPTRDTELVPSSTTAVHPSPGFLHTVSTSAPLDNLPLDVSQGPSGGDSLRVGPAPLPTPTlTSAGASTSAPTVILASL 536
Cdd:COG3469     60 GTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGS-VTSTTSSTAGSTTTSGA 138

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1214146097  537 PVSPPASTAASPLTSPAPGTAAPTSTSTATPSLTLPLCPAPVTALTTTSTPTPSPTPATALTLISSANPPPTSPPA 612
Cdd:COG3469    139 SATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPK 214
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 274-565 1.34e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 1.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  274 NLTSSLSAGPSLHHADkgLKAPQEMGLADAVDSRPQADSFKDVCGRSSlrlPPTSTAGSGAKGAESKETGSPSPRETRSi 353
Cdd:pfam05109  457 NLTAPASTGPTVSTAD--VTSPTPAGTTSGASPVTPSPSPRDNGTESK---APDMTSPTSAVTTPTPNATSPTPAVTTP- 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  354 laSKEARSREGGAGVVTSNVS-PSQGALpeelhSEACTVDQVAGQSKMEKLGeghlngKGRGSCQGKESKDVAGRPAAEQ 432
Cdd:pfam05109  531 --TPNATSPTLGKTSPTSAVTtPTPNAT-----SPTPAVTTPTPNATIPTLG------KTSPTSAVTTPTPNATSPTVGE 597

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  433 SFAPIMDTRKSTHGLSSTPSDTLP-----ASAPTRDTELVPSSTTAVHPSPGFLHTVSTSAPLDN----LPLDVSQGPSG 503
Cdd:pfam05109  598 TSPQANTTNHTLGGTSSTPVVTSPpknatSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNstshMPLLTSAHPTG 677

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1214146097  504 GDSLR--------------VGPAPLPTPTLTSAGASTSAPTVILASLPVSP--PASTAASPLTSPAPGTAAPTSTSTA 565
Cdd:pfam05109  678 GENITqvtpaststhhvstSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKgtPPKNATSPQAPSGQKTAVPTVTSTG 755
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 206-568 4.28e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 4.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  206 QDTTSPWHLPVGPLGPLGRGLGSLRRRRRPGASSGDRPCRPLKLDPLrlgtvvsvwdavdmAGSAGQDNLTSSLSAGPSL 285
Cdd:PHA03307   111 PSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGA--------------SPAAVASDAASSRQAALPL 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  286 HHADKGLKAPQEMGLADAVDSRPQADSfkdvcGRSSLRLPPTSTAGSGAKGAESKETGSPSPRETRSILASKEARSREGG 365
Cdd:PHA03307   177 SSPEETARAPSSPPAEPPPSTPPAAAS-----PRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGP 251

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  366 agvvtsnvspsQGALPEELHSEACTVDQVAGQSKMEKLGEGHLNGKGRGSCQGKESKDVAGRPAAEQSFAPIMDTRKSTH 445
Cdd:PHA03307   252 -----------ENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSS 320

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  446 GLSSTPSDTLPASAPTRDTELVPSSTTAVHPSPGflhtvSTSAPLDNLPLdvSQGPSGGDSLRVGPAPLPTPTLTSAGAS 525
Cdd:PHA03307   321 SRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS-----RPPPPADPSSP--RKRPRPSRAPSSPAASAGRPTRRRARAA 393

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 1214146097  526 TSAPTVILASLPVSPPASTAASPLTSPAPGTAAPTSTSTATPS 568
Cdd:PHA03307   394 VAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTPS 436
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
733-844 8.67e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.14  E-value: 8.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  733 TQPVSlETNASLTPDPRGdETKQKSLDLLPPAAEPVASPQV---PVSAQPG---PVPPTSMRQDAQPTPQPRQRRRKRSI 806
Cdd:PRK14971   384 TQPAA-APQPSAAAAASP-SPSQSSAAAQPSAPQSATQPAGtppTVSVDPPaavPVNPPSTAPQAVRPAQFKEEKKIPVS 461

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1214146097  807 AQSSEHILIQEVPQQPQGQVR---KEGARPTDcRDILTEKQ 844
Cdd:PRK14971   462 KVSSLGPSTLRPIQEKAEQATgniKEAPTGTQ-KEIFTEED 501
 
Name Accession Description Interval E-value
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 887-962 4.46e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 105.54  E-value: 4.46e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1214146097  887 LDLGSCLEVLAFAQQHGELGLAQETYVLMSNNLLHVLGDPHLYRQLSGADRERILNLRTCQGQTVLGVLVLPSLYQ 962
Cdd:cd18484      1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLEAGRACLVVAELNDVFE 76
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
991-1214 2.59e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 110.25  E-value: 2.59e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  991 LHVFNPQENVWWPLTQVPEEvPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNKVFCYNPLTNIWSQIRPMQQARAQLKLV 1070
Cdd:COG3055     40 FEVYDPATNTWSELAPLPGP-PRHHAAAVAQDGKLYVFGGFTGANPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATAL 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097 1071 ALDGMLYAIGGE----CLYSMERYDPRTDTWTLRASLPEGTFPVAhEAVVCRGEIYVTGGhlfyrlLRYSPMKDSWDECP 1146
Cdd:COG3055    119 LLDGKIYVVGGWddggNVAWVEVYDPATGTWTQLAPLPTPRDHLA-AAVLPDGKILVIGG------RNGSGFSNTWTTLA 191

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1214146097 1147 YSASHRRSSDMVALGGFLYRFDLLRGVGAAVMRYNTVTGSWSRAASLplsdPAPLHCTV---LGNTIYCLN 1214
Cdd:COG3055    192 PLPTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGEL----PTPRHGHAavlTDGKVYVIG 258
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
1054-1194 4.11e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 85.98  E-value: 4.11e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097 1054 WSQIRPMQQARAQLKLVALDGMLYAIGG----ECLYSMERYDPRTDTWTLRASLPEGtfPVAHEA-VVCRGEIYVTGG-- 1126
Cdd:COG3055      3 WSSLPDLPTPRSEAAAALLDGKVYVAGGlsggSASNSFEVYDPATNTWSELAPLPGP--PRHHAAaVAQDGKLYVFGGft 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1214146097 1127 ------HLFYRLLRYSPMKDSWDECPYSASHRRSSDMVALGGFLYRFDLLRGVG--AAVMRYNTVTGSWSRAASLP 1194
Cdd:COG3055     81 ganpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGnvAWVEVYDPATGTWTQLAPLP 156
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
992-1126 7.81e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 70.18  E-value: 7.81e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  992 HVFNPQENVWWPLTQVPeeVPLRGCGLCTMHNYLFLAGGIRGSGAkavcSNKVFCYNPLTNIWSQIRPMQQARAQLKLVA 1071
Cdd:COG3055     93 YVYDPATNTWTKLAPMP--TPRGGATALLLDGKIYVVGGWDDGGN----VAWVEVYDPATGTWTQLAPLPTPRDHLAAAV 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097 1072 L-DGMLYAIGG-----------------------------ECLY----------SMERYDPRTDTWTLRASLPEGTFpvA 1111
Cdd:COG3055    167 LpDGKILVIGGrngsgfsntwttlaplptaraghaaavlgGKILvfggesgfsdEVEAYDPATNTWTALGELPTPRH--G 244

                          170
                   ....*....|....*
gi 1214146097 1112 HEAVVCRGEIYVTGG 1126
Cdd:COG3055    245 HAAVLTDGKVYVIGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
 1010-1211 1.01e-11

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 69.03  E-value: 1.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097 1010 EVPLRGCGLC-TMHNYLFLAGGIRGSGakaVCSNKVFCYNPLTNIWSQIRPMQQARAQLKLVALDGMLYAIGG----ECL 1084
Cdd:PHA03098   281 DIHYVYCFGSvVLNNVIYFIGGMNKNN---LSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsISL 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097 1085 YSMERYDPRTDTWTLRASLPEGTFPVAheAVVCRGEIYVTGGHLFYRLL-----RYSPMKDSWDEC-PYSASHRRSSdMV 1158
Cdd:PHA03098   358 NTVESWKPGESKWREEPPLIFPRYNPC--VVNVNNLIYVIGGISKNDELlktveCFSLNTNKWSKGsPLPISHYGGC-AI 434

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1214146097 1159 ALGGFLY-----RFDLLRGVGAAVMRYNTVTGSWSRAASLPLSDPAPLHCtVLGNTIY 1211
Cdd:PHA03098   435 YHDGKIYviggiSYIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLC-IFNNKIY 491
PHA03247 PHA03247
large tegument protein UL36; Provisional
 427-786 2.03e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 62.65  E-value: 2.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  427 RPAAEQSFAPIMDTRKSThglsstPSDTLPASAPTRDTELVPSSttavhPSPGFLHTVSTSAPLDNLPLDVSQGPSggds 506
Cdd:PHA03247  2685 RRAARPTVGSLTSLADPP------PPPPTPEPAPHALVSATPLP-----PGPAAARQASPALPAAPAPPAVPAGPA---- 2749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  507 LRVGPAPLPTPTLTSAGASTSAPTVilaslPVSPPASTAASPLTSPApgtaaptstSTATPSLTLPLCPAPVTALTTTST 586
Cdd:PHA03247  2750 TPGGPARPARPPTTAGPPAPAPPAA-----PAAGPPRRLTRPAVASL---------SESRESLPSPWDPADPPAAVLAPA 2815

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  587 PtpsptpatalTLISSANPPPTSPPALASAPVAAQDPvadTEPRPKNTESNVGLSKSSPERRISNSWGNLITMVLRSHPF 666
Cdd:PHA03247  2816 A----------ALPPAASPAGPLPPPTSAQPTAPPPP---PGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPP 2882

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  667 PRQEKAQGSAPRADPESPAGPSPSTYSEDIQPGSSSEGAIFSLQDKHRPVLVTAVGSESLAEARCETQPVSLETNAslTP 746
Cdd:PHA03247  2883 VRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGA--VP 2960

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1214146097  747 DPRgdetkqksLDLLPPAAEPVASPQVPVSAQPGPVPPTS 786
Cdd:PHA03247  2961 QPW--------LGALVPGRVAVPRFRVPQPAPSREAPASS 2992
PHA03098 PHA03098
kelch-like protein; Provisional
 993-1104 1.11e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 55.93  E-value: 1.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  993 VFNPQENVWWPLTQVPeeVPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNkVFCYNPLTNIWSQIRPMQQARAQLKLVAL 1072
Cdd:PHA03098   410 CFSLNTNKWSKGSPLP--ISHYGGCAIYHDGKIYVIGGISYIDNIKVYNI-VESYNPVTNKWTELSSLNFPRINASLCIF 486

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1214146097 1073 DGMLYAIGGECLYS----MERYDPRTDTWTLRASLP 1104
Cdd:PHA03098   487 NNKIYVVGGDKYEYyineIEVYDDKTNTWTLFCKFP 522
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 1012-1061 1.45e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 48.76  E-value: 1.45e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1214146097 1012 PLRGCGLCTMHNYLFLAGGIRGSgakaVCSNKVFCYNPLTNIWSQIRPMQ 1061
Cdd:pfam01344    1 RRSGAGVVVVGGKIYVIGGFDGN----QSLNSVEVYDPETNTWSKLPSMP 46
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 443-786 1.79e-07

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 55.69  E-value: 1.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  443 STHGLSSTPSDTLPASAPTRDTE--LVPSSTTAVHPS---PGFLHTVSTSAPLDNLPLDVSQGPSGGDSlrvGPAPL-PT 516
Cdd:pfam05109  415 TTHKVIFSKAPESTTTSPTLNTTgfAAPNTTTGLPSSthvPTNLTAPASTGPTVSTADVTSPTPAGTTS---GASPVtPS 491

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  517 PTLTSAGASTSAPTVILASLPVSPPASTAASP---LTSPAPGTAAPTSTSTA-TPSLTLPL----CPAPVTALTTTSTPT 588
Cdd:pfam05109  492 PSPRDNGTESKAPDMTSPTSAVTTPTPNATSPtpaVTTPTPNATSPTLGKTSpTSAVTTPTpnatSPTPAVTTPTPNATI 571

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  589 PSPTPATALTLISSANPPPTSPPALASAPVA----------AQDPVADTEPR-------------PKNTESNVGLSKSSP 645
Cdd:pfam05109  572 PTLGKTSPTSAVTTPTPNATSPTVGETSPQAnttnhtlggtSSTPVVTSPPKnatsavttgqhniTSSSTSSMSLRPSSI 651

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  646 ERRISNSWGNLIT----MVLRSHP-----FPRQEKAQGSAPRADPESPAgPSPSTYSEDIQPGSSSEGA----------- 705
Cdd:pfam05109  652 SETLSPSTSDNSTshmpLLTSAHPtggenITQVTPASTSTHHVSTSSPA-PRPGTTSQASGPGNSSTSTkpgevnvtkgt 730

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  706 ---------IFSLQDKHRPVLVTAVGSESLAEARCETQPVSLETNASLTPDPRGD----ETKQKSLDLLPPAAEP----- 767
Cdd:pfam05109  731 ppknatspqAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDsttpRTRYNATTYLPPSTSSklrpr 810

                          410       420
                   ....*....|....*....|.
gi 1214146097  768 --VASPQVPVSAQPGPVPPTS 786
Cdd:pfam05109  811 wtFTSPPVTTAQATVPVPPTS 831
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 1063-1104 1.95e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 48.76  E-value: 1.95e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1214146097 1063 ARAQLKLVALDGMLYAIGG----ECLYSMERYDPRTDTWTLRASLP 1104
Cdd:pfam01344    1 RRSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
PHA03247 PHA03247
large tegument protein UL36; Provisional
 425-793 2.14e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 2.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  425 AGRPAAEQSFAPIMDTRKSTHGLSSTPSDTLPASAPTRDTELVPSSTTAVHPSPgflhTVSTSAPLDNLPLDV-SQGPSG 503
Cdd:PHA03247  2558 AAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGP----APPSPLPPDTHAPDPpPPSPSP 2633

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  504 GDSLRVGPAPLPTPTLTSAGASTSAPTVILASLPVSPP-ASTAASPLTSPAPGTAAPTSTSTATPSLTLPLCPAPVTALT 582
Cdd:PHA03247  2634 AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPH 2713

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  583 TTSTPTPSPTPATALTLISSANPPPTSPPALASAPVAaqdPVADTEPRPKNTESNVGLSK------SSPERRISNSWGNL 656
Cdd:PHA03247  2714 ALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT---PGGPARPARPPTTAGPPAPAppaapaAGPPRRLTRPAVAS 2790

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  657 ITMVLRSHPFPRQ----------------EKAQGSAPRADPESPAGPSPSTYSEDIQPGSSSEGAI-----FSLQDKHRP 715
Cdd:PHA03247  2791 LSESRESLPSPWDpadppaavlapaaalpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVapggdVRRRPPSRS 2870

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1214146097  716 VLVTAVGSESLAEARCETQPVSLETNASLTPDPRGDETKQKsldllPPAAEPVASPQVPVSAQPGPVPPTSMRQDAQP 793
Cdd:PHA03247  2871 PAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQP-----QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 435-681 2.32e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 51.88  E-value: 2.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  435 APIMDTRKSTHGLSSTPSDTLPASAPTRDTELVPSSTTAVHPSPGFLHTVSTSAPLDNLPLDVSQGPSGGDSLRVGPAPL 514
Cdd:pfam17823  117 AAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPT 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  515 PTPTLTSAGASTSAPTVILASLPVSPPAST--AASPLTSPAPGT---AAPTSTSTATPSLTL---PLCPAPVTALTTTST 586
Cdd:pfam17823  197 TAASSAPATLTPARGISTAATATGHPAAGTalAAVGNSSPAAGTvtaAVGTVTPAALATLAAaagTVASAAGTINMGDPH 276

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  587 PTPSPTPATALTLISSANPPPTSPPAL--ASAPVAAQDPVADTEPRPKNTESNVGLSKSSPERRISNSWGNLITMvlrsh 664
Cdd:pfam17823  277 ARRLSPAKHMPSDTMARNPAAPMGAQAqgPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTT----- 351

                          250
                   ....*....|....*..
gi 1214146097  665 pfprqeKAQGSAPRADP 681
Cdd:pfam17823  352 ------KAQAKEPSASP 362
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
994-1082 4.91e-06

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 49.77  E-value: 4.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  994 FNPQENVWWPLTQVPEevPLRGCGLCTMHNYLFLAGGIRGSgakavcSNKVFCYNPLTNIWSQIRPMQQARAQLKLVALD 1073
Cdd:COG3055    180 GSGFSNTWTTLAPLPT--ARAGHAAAVLGGKILVFGGESGF------SDEVEAYDPATNTWTALGELPTPRHGHAAVLTD 251


                   ....*....
gi 1214146097 1074 GMLYAIGGE 1082
Cdd:COG3055    252 GKVYVIGGE 260
Kelch smart00612
Kelch domain;
1076-1119 5.28e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.47  E-value: 5.28e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 1214146097  1076 LYAIGG----ECLYSMERYDPRTDTWTLRASLPEGTFPVAheAVVCRG 1119
Cdd:smart00612    2 IYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPTPRSGHG--VAVING 47
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 443-794 1.50e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.78  E-value: 1.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  443 STHGLSSTPSDTLPASAPTRDTELVPSSTTAVHPSPGFLHTVSTSAPLDNLPLDVSQGPSGGDSLRVGPAPLPTPTLTSA 522
Cdd:PHA03307    46 DSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPAS 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  523 GASTSAPtvILASLPVSPPASTAASPLTSPAPGTAAPTSTSTATPSLTLPLcPAPVTALTTTSTPTPSPTPATALTLIS- 601
Cdd:PHA03307   126 PPPSPAP--DLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAAL-PLSSPEETARAPSSPPAEPPPSTPPAAa 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  602 SANPPPTSPPALASAPVAAQDPVADTEPRPKNTESNVGLSKSSPERRISNSWGNLITMVLRSHPFPRQEKAQGSAPRADP 681
Cdd:PHA03307   203 SPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRP 282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  682 eSPAGPSPSTYSEDIQPGSSSEGAiFSLQDKHRPVLVTAVGSESLAEARCETQPVSLETNASLTPDPRGDETKQKsldll 761
Cdd:PHA03307   283 -GPASSSSSPRERSPSPSPSSPGS-GPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSR----- 355

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1214146097  762 PPAAEPVASPqvPVSAQPGPVPPTSMRQDAQPT 794
Cdd:PHA03307   356 PPPPADPSSP--RKRPRPSRAPSSPAASAGRPT 386
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 448-834 1.73e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.38  E-value: 1.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  448 SSTPSDTLPASAPTRDTELVPSSTTAVHPSPGFLHTVSTSAPLDNLPLDVSQGPSGGDSLRVGPAPLPTPTLTSAGASTS 527
Cdd:pfam03154  223 STAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTP 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  528 AptviLASLPVSPPASTAASPLTSPAPGTAAPTSTSTA-TPSLTLPLCPAPVTaltttstptpsptpataltlISSANPP 606
Cdd:pfam03154  303 Q----SSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSqQPPREQPLPPAPLS--------------------MPHIKPP 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  607 PTSPPALASAPVAAQDPVADTEPRPKNTESNVGLSKS-SPERRISNSWGNlitmvlRSHPFPRQEKAQGsapRADPESPA 685
Cdd:pfam03154  359 PTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPAlKPLSSLSTHHPP------SAHPPPLQLMPQS---QQLPPPPA 429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  686 GPSPSTYSEDIQPGSSSegaifslqdkHRPvlvtavgseslaearcetqPVSLETNASLTPDPRGDETKQKSLDLLPPAA 765
Cdd:pfam03154  430 QPPVLTQSQSLPPPAAS----------HPP-------------------TSGLHQVPSQSPFPQHPFVPGGPPPITPPSG 480

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1214146097  766 EPVASPqvpvSAQPGPVPPTSMRQDAQPTPQPRQRRRKRSIAQSSEHILIQEVPQQPQGQVRKEGARPT 834
Cdd:pfam03154  481 PPTSTS----SAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPT 545
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 447-691 2.05e-05

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 48.77  E-value: 2.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  447 LSSTPSDTLPASAPTRDTELVPSSTTAVHPSPgflhtvsTSAPLDNLP---LDVSQGP----SGGDSLRVGPAPLPTPTL 519
Cdd:PLN03209   320 LAKIPSQRVPPKESDAADGPKPVPTKPVTPEA-------PSPPIEEEPpqpKAVVPRPlspyTAYEDLKPPTSPIPTPPS 392

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  520 TSAGASTSAPTVILASLPVSPPASTAAS--PLTSPAPG---TAAPTSTSTATPSLTLPLCPAP-----VTALTTTSTPTP 589
Cdd:PLN03209   393 SSPASSKSVDAVAKPAEPDVVPSPGSASnvPEVEPAQVeakKTRPLSPYARYEDLKPPTSPSPtaptgVSPSVSSTSSVP 472

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  590 SPTPATALTLISSANPPPTSPPALASAPVAAQDPVADTEPRPKNTESNVGLSKSSPERRISNSWGNLITMVLRSHPFPRQ 669
Cdd:PLN03209   473 AVPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQHHAQPKP 552

                          250       260
                   ....*....|....*....|..
gi 1214146097  670 EKAQGSAPRADPESPAGPSPST 691
Cdd:PLN03209   553 RPLSPYTMYEDLKPPTSPTPSP 574
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 511-822 2.34e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.00  E-value: 2.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  511 PAPLPTPTLTSAGASTSAPTVILASLPvsPPASTAASPLTSPAPGTAAPTSTSTATPSLTLPLCPAP-VTALTTTSTPTP 589
Cdd:pfam03154  181 ASPPSPPPPGTTQAATAGPTPSAPSVP--PQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPhPPLQPMTQPPPP 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  590 SPTPATALTLISSANPPPTSPPALASAPVAAQDPVAdTEPRPKNTESNVGLSKSSPERRISNSWGNLITMvlrshPFPRQ 669
Cdd:pfam03154  259 SQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVP-PQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHT-----PPSQS 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  670 EKAQGSAPRadpESPAGPSPSTYSEDIQPGSSSEGAIFSLQDKHRPVLVTAvgseslaearcetqPVSLETNASLTPDPr 749
Cdd:pfam03154  333 QLQSQQPPR---EQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSG--------------PSPFQMNSNLPPPP- 394

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1214146097  750 gdetKQKSLDLLPPAAEPVASP---QVPVSAQPGPVPPtsmrqdAQPTPQPRQRRRKRSIAQSSEHILIQEVPQQP 822
Cdd:pfam03154  395 ----ALKPLSSLSTHHPPSAHPpplQLMPQSQQLPPPP------AQPPVLTQSQSLPPPAASHPPTSGLHQVPSQS 460
Kelch smart00612
Kelch domain;
1025-1074 3.18e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.16  E-value: 3.18e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1214146097  1025 LFLAGGIRGSgakaVCSNKVFCYNPLTNIWSQIRPMQQARAQLKLVALDG 1074
Cdd:smart00612    2 IYVVGGFDGG----QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
PHA02713 PHA02713
hypothetical protein; Provisional
 1023-1214 1.43e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 46.16  E-value: 1.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097 1023 NYLFLAGGIRGSGAKAvcsNKVFCYNPLTNIWSQIRPMQQARAQLKLVALDGMLYAIGGECLYSMER----YDPRTDTWT 1098
Cdd:PHA02713   304 NEIIIAGGYNFNNPSL---NKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERtiecYTMGDDKWK 380

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097 1099 LRASLPEGTfpVAHEAVVCRGEIYVTGG---HLFY-------------------RLLRYSPMKDSWDECPYSASHRRSSD 1156
Cdd:PHA02713   381 MLPDMPIAL--SSYGMCVLDQYIYIIGGrteHIDYtsvhhmnsidmeedthssnKVIRYDTVNNIWETLPNFWTGTIRPG 458

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1214146097 1157 MVALGGFLYRF-DLL--RGVGAAVMRYNTVTGSWSRAASLPLSDPAPLHCTVLGNTIYCLN 1214
Cdd:PHA02713   459 VVSHKDDIYVVcDIKdeKNVKTCIFRYNTNTYNGWELITTTESRLSALHTILHDNTIMMLH 519
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
456-656 2.42e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.25  E-value: 2.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  456 PASAPTRDTELVPSSTTAVHPSPGflhTVSTSAPLDNLPLDVSQGPSGGDSlRVGPAPLPTPTLTSAGASTSAPTVILAS 535
Cdd:PRK12323   377 AAAAPVAQPAPAAAAPAAAAPAPA---APPAAPAAAPAAAAAARAVAAAPA-RRSPAPEALAAARQASARGPGGAPAPAP 452

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  536 LPVSPPASTAASPLTSP---------APGTAAPTSTSTATPSLTLP---LCPAPVTALTTTSTPTPSPTPATALTLISSA 603
Cdd:PRK12323   453 APAAAPAAAARPAAAGPrpvaaaaaaAPARAAPAAAPAPADDDPPPweeLPPEFASPAPAQPDAAPAGWVAESIPDPATA 532

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1214146097  604 NPPPTSpPALASAPVAAQDPVADTEPRPKNTESNVGLSKSSPERRISNSWGNL 656
Cdd:PRK12323   533 DPDDAF-ETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPAL 584
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
457-612 6.22e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 43.97  E-value: 6.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  457 ASAPTRDTELVPSSTTAVHPSPGFLHTVSTSAPLDNLPLDVSQGPSGGDSLRVGPAPLPTPTlTSAGASTSAPTVILASL 536
Cdd:COG3469     60 GTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGS-VTSTTSSTAGSTTTSGA 138

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1214146097  537 PVSPPASTAASPLTSPAPGTAAPTSTSTATPSLTLPLCPAPVTALTTTSTPTPSPTPATALTLISSANPPPTSPPA 612
Cdd:COG3469    139 SATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPK 214
Kelch_3 pfam13415
Galactose oxidase, central domain;
1023-1065 7.32e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.43  E-value: 7.32e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1214146097 1023 NYLFLAGGIRGSGAKavCSNKVFCYNPLTNIWSQIRPMQQARA 1065
Cdd:pfam13415    2 DKLYIFGGLGFDGQT--RLNDLYVYDLDTNTWTQIGDLPPPRS 42
PHA03379 PHA03379
EBNA-3A; Provisional
 412-791 8.24e-04

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 43.89  E-value: 8.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  412 GRGSCQGKESKDVAGRPAAEQSFAPIMDTRKSTHGLSSTPSDTLPASAPTrdtelvPSSTTAVHPSPGFLHTVSTSAPLD 491
Cdd:PHA03379   395 GKLTERAREALEKASEPTYGTPRPPVEKPRPEVPQSLETATSHGSAQVPE------PPPVHDLEPGPLHDQHSMAPCPVA 468

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  492 NLPLDVSQGPSGGDSL-------RVGPAPLPTPTLTSAGASTSAPTVI--LASLPVSPpastaaspltSPAPGTAAPTST 562
Cdd:PHA03379   469 QLPPGPLQDLEPGDQLpgvvqdgRPACAPVPAPAGPIVRPWEASLSQVpgVAFAPVMP----------QPMPVEPVPVPT 538

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  563 StatpSLTLPLCPAPvtaltttstptpsptpatalTLISSANPPPTSPPALASAPVAAQdPVADTEPRPKNTES-NVGLS 641
Cdd:PHA03379   539 V----ALERPVCPAP--------------------PLIAMQGPGETSGIVRVRERWRPA-PWTPNPPRSPSQMSvRDRLA 593

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  642 KSSPERRIsnswgnlitmvlRSHPFPRQEKaqgSAPRADPESPAgPSPSTYSEDIQPGSSSEGAIFSLQDKHRPVLVTAV 721
Cdd:PHA03379   594 RLRAEAQP------------YQASVEVQPP---QLTQVSPQQPM-EYPLEPEQQMFPGSPFSQVADVMRAGGVPAMQPQY 657

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1214146097  722 GSESLAEARCETQPVSLeTNASLTPDPRGDETKQKSLDLlpPAAEPVAS--------PQVPvsAQPGPVPPTSMRQDA 791
Cdd:PHA03379   658 FDLPLQQPISQGAPLAP-LRASMGPVPPVPATQPQYFDI--PLTEPINQgasaahflPQQP--MEGPLVPERWMFQGA 730
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 1112-1146 9.64e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.98  E-value: 9.64e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1214146097 1112 HEAVVCRGEIYVTGGHLFYRLL----RYSPMKDSWDECP 1146
Cdd:pfam01344    5 AGVVVVGGKIYVIGGFDGNQSLnsveVYDPETNTWSKLP 43
PHA03247 PHA03247
large tegument protein UL36; Provisional
 326-784 1.08e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  326 PTSTAGSGAKGAESKETGSPSPRETRSILASKEARSREGGAGVVTSNVSPSQGALPEELHSEACTVDQVAGQSKmeklge 405
Cdd:PHA03247  2720 PLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSE------ 2793

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  406 ghlngkgrGSCQGKESKDVAGRPAAEQSFAPIMDTRKSTHGLSSTPSDTLPASAPtrdtelvpsstTAVHPSPGFLHTVS 485
Cdd:PHA03247  2794 --------SRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP-----------PPPGPPPPSLPLGG 2854

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  486 TSAPldnlpldvsqgpsGGDSLRVGPAPLPTPTLTsagASTSAPTVILASLPVSPPASTAASPLTSPAPgTAAPTSTSTA 565
Cdd:PHA03247  2855 SVAP-------------GGDVRRRPPSRSPAAKPA---APARPPVRRLARPAVSRSTESFALPPDQPER-PPQPQAPPPP 2917

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  566 TPSLTLPLCPAPvtaltttstptpsptpataltlissanPPPTSPPALASAPVAaqdPVADTEPRPKntesnvglskssP 645
Cdd:PHA03247  2918 QPQPQPPPPPQP---------------------------QPPPPPPPRPQPPLA---PTTDPAGAGE------------P 2955

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  646 ERRISNSWgnLITMVLRSHPFPRQEKAQGSAPRADPESPagPSPSTYSEDIQPGSSSEGAIFSLQDKHRPV--LVTAVGS 723
Cdd:PHA03247  2956 SGAVPQPW--LGALVPGRVAVPRFRVPQPAPSREAPASS--TPPLTGHSLSRVSSWASSLALHEETDPPPVslKQTLWPP 3031

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1214146097  724 ESLAEArcetqpvslETNASLTPDPRGDETkqKSLDLLPPaaepvaSPQVPVSAQPGPVPP 784
Cdd:PHA03247  3032 DDTEDS---------DADSLFDSDSERSDL--EALDPLPP------EPHDPFAHEPDPATP 3075
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 274-565 1.34e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 1.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  274 NLTSSLSAGPSLHHADkgLKAPQEMGLADAVDSRPQADSFKDVCGRSSlrlPPTSTAGSGAKGAESKETGSPSPRETRSi 353
Cdd:pfam05109  457 NLTAPASTGPTVSTAD--VTSPTPAGTTSGASPVTPSPSPRDNGTESK---APDMTSPTSAVTTPTPNATSPTPAVTTP- 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  354 laSKEARSREGGAGVVTSNVS-PSQGALpeelhSEACTVDQVAGQSKMEKLGeghlngKGRGSCQGKESKDVAGRPAAEQ 432
Cdd:pfam05109  531 --TPNATSPTLGKTSPTSAVTtPTPNAT-----SPTPAVTTPTPNATIPTLG------KTSPTSAVTTPTPNATSPTVGE 597

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  433 SFAPIMDTRKSTHGLSSTPSDTLP-----ASAPTRDTELVPSSTTAVHPSPGFLHTVSTSAPLDN----LPLDVSQGPSG 503
Cdd:pfam05109  598 TSPQANTTNHTLGGTSSTPVVTSPpknatSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNstshMPLLTSAHPTG 677

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1214146097  504 GDSLR--------------VGPAPLPTPTLTSAGASTSAPTVILASLPVSP--PASTAASPLTSPAPGTAAPTSTSTA 565
Cdd:pfam05109  678 GENITqvtpaststhhvstSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKgtPPKNATSPQAPSGQKTAVPTVTSTG 755
Kelch_6 pfam13964
Kelch motif;
1015-1064 2.11e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.31  E-value: 2.11e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1214146097 1015 GCGLCTMHNYLFLAGGIRGSGAKavcSNKVFCYNPLTNIWSQIRPMQQAR 1064
Cdd:pfam13964    4 FHSVVSVGGYIYVFGGYTNASPA---LNKLEVYNPLTKSWEELPPLPTPR 50
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
500-793 2.61e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.14  E-value: 2.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  500 GPSGGDSLRV-----GPAPLPTPTLTSAGASTSAPTVILASLPVSPPASTAASPLTSPAPgTAAPTSTSTATPSLTLPLC 574
Cdd:PRK07003   367 APGGGVPARVagavpAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAP-PAAPAPPATADRGDDAADG 445

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  575 PAPVTALTTTSTPTPSPTPataltlisSANPPPTSPPALASAPVAAQDPVADTEPRPKNTESNVGLSKSSPERRISNSwg 654
Cdd:PRK07003   446 DAPVPAKANARASADSRCD--------ERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAA-- 515

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  655 nlitmVLRSHPFPRQEKAqgsAPRADPESPAGPSPStysediqpgSSSEGAIFSLQdkhrpVLVTAVGSESLAEARcetq 734
Cdd:PRK07003   516 -----ASREDAPAAAAPP---APEARPPTPAAAAPA---------ARAGGAAAALD-----VLRNAGMRVSSDRGA---- 569

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1214146097  735 pvsletNASLTPDPRGDetkqksldllPPAAEPVASPQVPVsaqPGPVPPTSMRQDAQP 793
Cdd:PRK07003   570 ------RAAAAAKPAAA----------PAAAPKPAAPRVAV---QVPTPRARAATGDAP 609
PRK10856 PRK10856
cytoskeleton protein RodZ;
491-568 2.64e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 41.55  E-value: 2.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  491 DNLPLDVSQGPSGGDSLRVGPAPLPTPTLTS--AGASTSAPTVILASLPVSPPASTAASPLTSPAPGTAAPTSTSTATPS 568
Cdd:PRK10856   160 QSVPLDTSTTTDPATTPAPAAPVDTTPTNSQtpAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAPATPDGAAPLPT 239
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
446-625 2.84e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.14  E-value: 2.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  446 GLSSTPSDTLPASAPTRDTELVPSSTTAVHPSPGFLHTVSTSAPLDNLPLDVSQGPSggdslrVGPAPLPTPTLTSAGAS 525
Cdd:PRK07003   371 GVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPP------AAPAPPATADRGDDAAD 444

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  526 TSAPTVILASLPVSP---PASTAASPLTSPAPGTAAptsTSTATPSLTLPLCPAPVTALTTTSTPTPSPTPATALTLISS 602
Cdd:PRK07003   445 GDAPVPAKANARASAdsrCDERDAQPPADSGSASAP---ASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDA 521

                          170       180
                   ....*....|....*....|...
gi 1214146097  603 ANPPPTSPPALASAPVAAQDPVA 625
Cdd:PRK07003   522 PAAAAPPAPEARPPTPAAAAPAA 544
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
500-691 3.03e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 3.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  500 GPSGGD----SLRVGPAPLPTPTLTSAGASTSAPTVILASLPVSPPASTAASPLTSpAPGTAAPTSTSTATPSLTLPLCP 575
Cdd:PRK12323   366 GQSGGGagpaTAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAA-APARRSPAPEALAAARQASARGP 444

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  576 APVTALTTTSTPTPSPTPATaltlissANPPPTSPPALASAPVAAQDPVADTEPRPKNTESNVGLSKSSPERRISNSWGN 655
Cdd:PRK12323   445 GGAPAPAPAPAAAPAAAARP-------AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAA 517

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1214146097  656 LITMVLRSHPFPRQEKAQGSAPRADPESPAGPSPST 691
Cdd:PRK12323   518 PAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRA 553
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 511-624 3.90e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 3.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  511 PAPLPTPTLTSAGASTSAPTVILASLPVSPPAsTAASPLTSPAPGTAAPTSTSTATPSltlPLCPAPVTALTTTSTPTPS 590
Cdd:PRK14951   387 AAPAAAPVAQAAAAPAPAAAPAAAASAPAAPP-AAAPPAPVAAPAAAAPAAAPAAAPA---AVALAPAPPAQAAPETVAI 462

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1214146097  591 PTPATALTLISSANPPPTSPPALASAPVAAQDPV 624
Cdd:PRK14951   463 PVRVAPEPAVASAAPAPAAAPAAARLTPTEEGDV 496
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 206-568 4.28e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 4.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  206 QDTTSPWHLPVGPLGPLGRGLGSLRRRRRPGASSGDRPCRPLKLDPLrlgtvvsvwdavdmAGSAGQDNLTSSLSAGPSL 285
Cdd:PHA03307   111 PSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGA--------------SPAAVASDAASSRQAALPL 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  286 HHADKGLKAPQEMGLADAVDSRPQADSfkdvcGRSSLRLPPTSTAGSGAKGAESKETGSPSPRETRSILASKEARSREGG 365
Cdd:PHA03307   177 SSPEETARAPSSPPAEPPPSTPPAAAS-----PRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGP 251

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  366 agvvtsnvspsQGALPEELHSEACTVDQVAGQSKMEKLGEGHLNGKGRGSCQGKESKDVAGRPAAEQSFAPIMDTRKSTH 445
Cdd:PHA03307   252 -----------ENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSS 320

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  446 GLSSTPSDTLPASAPTRDTELVPSSTTAVHPSPGflhtvSTSAPLDNLPLdvSQGPSGGDSLRVGPAPLPTPTLTSAGAS 525
Cdd:PHA03307   321 SRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS-----RPPPPADPSSP--RKRPRPSRAPSSPAASAGRPTRRRARAA 393

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 1214146097  526 TSAPTVILASLPVSPPASTAASPLTSPAPGTAAPTSTSTATPS 568
Cdd:PHA03307   394 VAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTPS 436
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 510-629 4.35e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 4.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  510 GPAPLPTPTLTSAGASTSAPTVILASLPVSPPASTAASPLTSPAPgTAAPTSTSTATPSLTLPLCPAPVTALTTTSTPTP 589
Cdd:PRK14951   370 AEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAP-AAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALA 448

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1214146097  590 SPTPATALTLISS-----ANPPPTSPPALASAPVAAQDPVADTEP 629
Cdd:PRK14951   449 PAPPAQAAPETVAipvrvAPEPAVASAAPAPAAAPAAARLTPTEE 493
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
443-598 4.53e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 41.28  E-value: 4.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  443 STHGLSSTPSDTLPASAPTrdtelVPSSTTAVHPSPGFLHTVSTSAPLDNLPLDVSQGPSGGDSLRVGPAPLPTPTLTSA 522
Cdd:COG3469     68 STAATSSTTSTTATATAAA-----AAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATS 142

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1214146097  523 GASTSAPTVILASLPVSPPASTAASPLTSPAPGTAAPTSTSTATPSLTLPLCPAPVTALTTTSTPTPSPTPATALT 598
Cdd:COG3469    143 SAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPKHVLV 218
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
515-705 4.53e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 4.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  515 PTPTLTSAGASTSAPTVILASLPVSPPASTAASPLTSPAPGTAAPTSTSTATPSLTLPLCPAPVTALTTTSTPTPSPTPA 594
Cdd:PRK07003   360 PAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRG 439

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  595 TAltliSSANPPPTSPPALASAPVAAQDPVADTEPRPKNTESNVGLSKSSPE-RRISNSWGNLITMVLRshPFPRQEKAQ 673
Cdd:PRK07003   440 DD----AADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDaAFEPAPRAAAPSAATP--AAVPDARAP 513

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1214146097  674 GSAPRAD-PESPAGPSPSTYSEdiQPGSSSEGA 705
Cdd:PRK07003   514 AAASREDaPAAAAPPAPEARPP--TPAAAAPAA 544
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 510-632 5.37e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 5.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  510 GPAPLPTPTLTSAGASTSAPTVILASLPVSPPASTAASPLTSPAPGTAAPTSTSTATPSLTLPLCPAPVTALTTTSTPTP 589
Cdd:PRK07764   389 GGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAP 468

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1214146097  590 SPTPATALTLIS----SANPPPTSPPALASAPVAAQDPVADTEPRPK 632
Cdd:PRK07764   469 APAAAPEPTAAPapapPAAPAPAAAPAAPAAPAAPAGADDAATLRER 515
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 448-568 5.57e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 40.87  E-value: 5.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  448 SSTPSDTLPASAPTRDTELVPSSTTAVHPSPGflHTVSTSAPLDNLPlDVSQGPSGGDSLRVGPAPLPTPTLTSAGASTS 527
Cdd:PHA03269    24 TNIPIPELHTSAATQKPDPAPAPHQAASRAPD--PAVAPTSAASRKP-DLAQAPTPAASEKFDPAPAPHQAASRAPDPAV 100

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1214146097  528 APTVILASLPVSPPASTAAsPLTSPAPgTAAPTSTSTATPS 568
Cdd:PHA03269   101 APQLAAAPKPDAAEAFTSA-AQAHEAP-ADAGTSAASKKPD 139
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
451-630 5.64e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 5.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  451 PSDTLPASAPTRDTELVPSSTTAVHPSPGFLHTVSTSAP--LDNLPLDVSQGPSGGDSLRVGPAPLPTPTLTSAGASTSA 528
Cdd:PRK12323   392 PAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPeaLAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRP 471

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  529 PTVILASLPVSP-PASTAASPLTSPAPGTAAPTSTSTATPSLTLPLCPAPVTALTTTSTPTPSPTPATalTLISSANPPP 607
Cdd:PRK12323   472 VAAAAAAAPARAaPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFE--TLAPAPAAAP 549

                          170       180
                   ....*....|....*....|...
gi 1214146097  608 TSPPALASAPVAAQDPVADTEPR 630
Cdd:PRK12323   550 APRAAAATEPVVAPRPPRASASG 572
Kelch_6 pfam13964
Kelch motif;
1063-1106 5.76e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.16  E-value: 5.76e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1214146097 1063 ARAQLKLVALDGMLYAIGGEC-----LYSMERYDPRTDTWTLRASLPEG 1106
Cdd:pfam13964    1 PRTFHSVVSVGGYIYVFGGYTnaspaLNKLEVYNPLTKSWEELPPLPTP 49
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 503-690 6.05e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 6.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  503 GGDSLRVGPAPLPTPTLTSAGASTSAPTvilaslpvsPPASTAASPLTSPAPGTAAPTSTSTATPSLTLPLCPAPVTALT 582
Cdd:PRK07764   589 GPAPGAAGGEGPPAPASSGPPEEAARPA---------APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAV 659

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  583 TTSTPTPSPTPATALTLISSANPP---PTSPPALASAPVAAQDPVADTEPRPKNTESNVGLSKSSPERRISNSWGNLITM 659
Cdd:PRK07764   660 PDASDGGDGWPAKAGGAAPAAPPPapaPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPV 739

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1214146097  660 VLRSHPFPRQEKAQGSAPRADPESPAGPSPS 690
Cdd:PRK07764   740 PLPPEPDDPPDPAGAPAQPPPPPAPAPAAAP 770
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 714-838 7.08e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.56  E-value: 7.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  714 RPVLVTAVGSESLAEARCETQPVSLETNASLTPDPRGDETKQKSLDLLPPAAEPVASPQVPVSAQPGPVPPTSMRQDAQP 793
Cdd:PRK14950   363 VPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPVDEKP 442

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1214146097  794 TPQPRQRRRKRSIAQSSEHILIQEV------------PQQPQGQ-VRKEGARPTDCRD 838
Cdd:PRK14950   443 KYTPPAPPKEEEKALIADGDVLEQLeaiwkqilrdvpPRSPAVQaLLSSGVRPVSVEK 500
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 494-578 7.91e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.56  E-value: 7.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  494 PLDVSQGPSGGDSLRVGPAPLPTPTLTSAGASTSAPTVILASLPVSPPASTAASPLTSPAPgtAAPTSTSTATPSLTLPL 573
Cdd:PRK14950   366 PQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPE--SAPKLTRAAIPVDEKPK 443


                   ....*
gi 1214146097  574 CPAPV 578
Cdd:PRK14950   444 YTPPA 448
motB PRK12799
flagellar motor protein MotB; Reviewed
 483-576 8.10e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 40.08  E-value: 8.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  483 TVSTSAPLDNLPLDVSQGPSGGDSLRVGPAPLPTPTLTSAGASTSAPTVILAS---------------LPVSPPASTAAS 547
Cdd:PRK12799   298 TVPVAAVTPSSAVTQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAVALSSagvlpsdvtlpgtvaLPAAEPVNMQPQ 377

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1214146097  548 PLTSPAPGTAAPTSTSTAT--PSLTLPLCPA 576
Cdd:PRK12799   378 PMSTTETQQSSTGNITSTAngPTTSLPAAPA 408
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 429-648 8.40e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 8.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  429 AAEQSFAPIMDTRKSTHGLSSTPSDTlpASAPTRDTELVPSSTTAV-HPSPGFLHTVSTSAPLDNLP--LDVSQGPSGGD 505
Cdd:PHA03307   214 SASASSPAPAPGRSAADDAGASSSDS--SSSESSGCGWGPENECPLpRPAPITLPTRIWEASGWNGPssRPGPASSSSSP 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  506 SlrvGPAPLPTPTLTSAGASTSAPTvILASLPVSPPASTAASPLTSPAPGTAAPTSTSTATPSLTLPLCPAPvtalttts 585
Cdd:PHA03307   292 R---ERSPSPSPSSPGSGPAPSSPR-ASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPP-------- 359

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1214146097  586 tptpsptpataltliSSANPPPTSPPALASAPVAAQDPVADTEPRPKNTESNVGLSKSSPERR 648
Cdd:PHA03307   360 ---------------ADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRF 407
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 424-636 8.64e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 8.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  424 VAGRPAAEQSFAPIMDTRKSTHGLSSTPSDTLPASAPTRDtelvPSSTTAVHPSPGFLHTVSTSAPLDNLPLDV-SQGPS 502
Cdd:PRK07764   588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAP----APAGAAAAPAEASAAPAPGVAAPEHHPKHVaVPDAS 663

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  503 GGDSLRVGPAPLPTPTltsAGASTSAPTVILASLPVSPPASTAASPLTSPAPGTAAPTSTSTATPSLTLPlcPAPVTALT 582
Cdd:PRK07764   664 DGGDGWPAKAGGAAPA---APPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASA--PSPAADDP 738

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1214146097  583 TTSTPTPSPTPATALTLISSANPPPTSPPALASAPVAAQDPVADTEPRPKNTES 636
Cdd:PRK07764   739 VPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPS 792
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
733-844 8.67e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.14  E-value: 8.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1214146097  733 TQPVSlETNASLTPDPRGdETKQKSLDLLPPAAEPVASPQV---PVSAQPG---PVPPTSMRQDAQPTPQPRQRRRKRSI 806
Cdd:PRK14971   384 TQPAA-APQPSAAAAASP-SPSQSSAAAQPSAPQSATQPAGtppTVSVDPPaavPVNPPSTAPQAVRPAQFKEEKKIPVS 461

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1214146097  807 AQSSEHILIQEVPQQPQGQVR---KEGARPTDcRDILTEKQ 844
Cdd:PRK14971   462 KVSSLGPSTLRPIQEKAEQATgniKEAPTGTQ-KEIFTEED 501
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 511-555 8.87e-03

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 38.30  E-value: 8.87e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1214146097  511 PAPLPTPTLTSAGASTSAPTVILASLPVSPPASTAASPLTSPAPG 555
Cdd:PRK05641    49 QEQVPTPAPAPAPAVPSAPTPVAPAAPAPAPASAGENVVTAPMPG 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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