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Conserved domains on  [gi|238550202|ref|NP_001153880|]
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tubby-related protein 3 isoform 2 [Homo sapiens]

Protein Classification

tubby family protein( domain architecture ID 11070239)

tubby (TUB) family protein similar to Mus musculus tubby protein that binds to membranes containing phosphatidylinositol 4,5-bisphosphate and functions in signal transduction from heterotrimeric G protein-coupled receptors; tubby family protein plays an important role in maintenance and function of neuronal cells during post differentiation and development in mammals, and may participate in the abscisic acid (ABA) signaling pathway in plants

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tub pfam01167
Tub family;
193-436 7.37e-133

Tub family;


:

Pssm-ID: 460094  Cd Length: 251  Bit Score: 384.62  E-value: 7.37e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202  193 YSPAPQGVTVRCRIIRDKRGMdrGLFPTYYMYLEKE--ENQKiFLLAARKRKKSKTANYLISIDPVDLSREGESYVGKLR 270
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSpgDGGK-FLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202  271 SNLMGTKFTVYDR-----GICPMKGRGLVGAAH---TRQELAAISYETNVLGFKGPRKMSVIIPGMTLNHKQIPYQPQNN 342
Cdd:pfam01167  78 SNFLGTKFTLYDNqppynGANPSKSRSSFGSKKvspGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202  343 HdSLLSRWQNRTMENLVELHNKAPVWNSDTQSYVLNFRGRVTQASVKNFQIVHKNDPDYIVMQFGRVADDVFTLDYNYPL 422
Cdd:pfam01167 158 S-SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPL 236

                         250
                  ....*....|....
gi 238550202  423 CAVQAFGIGLSSFD 436
Cdd:pfam01167 237 SAFQAFAICLSSFD 250
Tub_N super family cl24783
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 31-171 2.27e-36

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


The actual alignment was detected with superfamily member pfam16322:

Pssm-ID: 465092  Cd Length: 196  Bit Score: 133.39  E-value: 2.27e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202   31 QRLLLEKRQRKKRLEPFMVQPNPEARLRRAKPRASDEQTPLVNCHTP-HSNVILH------------------------- 84
Cdd:pfam16322   2 QRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSgNSGTIYHvqeaaprsakrsgahaalgtqggdg 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202   85 -GIDGPAAVLKPD------EVHAPSVSSSVVEEDAE--------NTVDTASKPGLQERLQKHDISESVNFD-EETDGISQ 148
Cdd:pfam16322  82 kGIDGPAAFLTEEpqdsgsELQILSVGDSPTSPPPDeelqepgaSGEEESSKQDLGDEMQKKGISSSMNFDeEEEDEEEE 161

                         170       180       190
                  ....*....|....*....|....*....|....
gi 238550202  149 S----------ACLERPNSASSQNST-DTGTSGS 171
Cdd:pfam16322 162 SssrssqlnsnEESTRPSSATSKKSSsEVGSSPS 195
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
193-436 7.37e-133

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 384.62  E-value: 7.37e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202  193 YSPAPQGVTVRCRIIRDKRGMdrGLFPTYYMYLEKE--ENQKiFLLAARKRKKSKTANYLISIDPVDLSREGESYVGKLR 270
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSpgDGGK-FLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202  271 SNLMGTKFTVYDR-----GICPMKGRGLVGAAH---TRQELAAISYETNVLGFKGPRKMSVIIPGMTLNHKQIPYQPQNN 342
Cdd:pfam01167  78 SNFLGTKFTLYDNqppynGANPSKSRSSFGSKKvspGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202  343 HdSLLSRWQNRTMENLVELHNKAPVWNSDTQSYVLNFRGRVTQASVKNFQIVHKNDPDYIVMQFGRVADDVFTLDYNYPL 422
Cdd:pfam01167 158 S-SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPL 236

                         250
                  ....*....|....
gi 238550202  423 CAVQAFGIGLSSFD 436
Cdd:pfam01167 237 SAFQAFAICLSSFD 250
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 31-171 2.27e-36

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 133.39  E-value: 2.27e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202   31 QRLLLEKRQRKKRLEPFMVQPNPEARLRRAKPRASDEQTPLVNCHTP-HSNVILH------------------------- 84
Cdd:pfam16322   2 QRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSgNSGTIYHvqeaaprsakrsgahaalgtqggdg 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202   85 -GIDGPAAVLKPD------EVHAPSVSSSVVEEDAE--------NTVDTASKPGLQERLQKHDISESVNFD-EETDGISQ 148
Cdd:pfam16322  82 kGIDGPAAFLTEEpqdsgsELQILSVGDSPTSPPPDeelqepgaSGEEESSKQDLGDEMQKKGISSSMNFDeEEEDEEEE 161

                         170       180       190
                  ....*....|....*....|....*....|....
gi 238550202  149 S----------ACLERPNSASSQNST-DTGTSGS 171
Cdd:pfam16322 162 SssrssqlnsnEESTRPSSATSKKSSsEVGSSPS 195
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
193-436 7.37e-133

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 384.62  E-value: 7.37e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202  193 YSPAPQGVTVRCRIIRDKRGMdrGLFPTYYMYLEKE--ENQKiFLLAARKRKKSKTANYLISIDPVDLSREGESYVGKLR 270
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSpgDGGK-FLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202  271 SNLMGTKFTVYDR-----GICPMKGRGLVGAAH---TRQELAAISYETNVLGFKGPRKMSVIIPGMTLNHKQIPYQPQNN 342
Cdd:pfam01167  78 SNFLGTKFTLYDNqppynGANPSKSRSSFGSKKvspGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202  343 HdSLLSRWQNRTMENLVELHNKAPVWNSDTQSYVLNFRGRVTQASVKNFQIVHKNDPDYIVMQFGRVADDVFTLDYNYPL 422
Cdd:pfam01167 158 S-SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPL 236

                         250
                  ....*....|....
gi 238550202  423 CAVQAFGIGLSSFD 436
Cdd:pfam01167 237 SAFQAFAICLSSFD 250
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 31-171 2.27e-36

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 133.39  E-value: 2.27e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202   31 QRLLLEKRQRKKRLEPFMVQPNPEARLRRAKPRASDEQTPLVNCHTP-HSNVILH------------------------- 84
Cdd:pfam16322   2 QRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSgNSGTIYHvqeaaprsakrsgahaalgtqggdg 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550202   85 -GIDGPAAVLKPD------EVHAPSVSSSVVEEDAE--------NTVDTASKPGLQERLQKHDISESVNFD-EETDGISQ 148
Cdd:pfam16322  82 kGIDGPAAFLTEEpqdsgsELQILSVGDSPTSPPPDeelqepgaSGEEESSKQDLGDEMQKKGISSSMNFDeEEEDEEEE 161

                         170       180       190
                  ....*....|....*....|....*....|....
gi 238550202  149 S----------ACLERPNSASSQNST-DTGTSGS 171
Cdd:pfam16322 162 SssrssqlnsnEESTRPSSATSKKSSsEVGSSPS 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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