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Conserved domains on  [gi|238814335|ref|NP_001154929|]
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core-binding factor subunit beta isoform 3 [Mus musculus]

Protein Classification

CBF_beta domain-containing protein( domain architecture ID 10491866)

CBF_beta domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CBF_beta pfam02312
Core binding factor beta subunit; Core binding factor (CBF) is a heterodimeric transcription ...
 1-133 5.92e-86

Core binding factor beta subunit; Core binding factor (CBF) is a heterodimeric transcription factor essential for genetic regulation of hematopoiesis and osteogenesis. The beta subunit enhances DNA-binding ability of the alpha subunit in vitro, and has been show to have a structure related to the OB fold.


:

Pssm-ID: 396750  Cd Length: 166  Bit Score: 248.81  E-value: 5.92e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238814335    1 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQTRFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQT 80
Cdd:pfam02312   1 MPRVVPDQKSKFESDELFRRLSRESEIKYTGFRDRPHEERQVRFQNGCREGHAEIAFVATGTNLQLQFEPNQTSGTQYHT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 238814335   81 PsREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLHRLDGMGCLEFDEERAQ 133
Cdd:pfam02312  81 P-GEECDFEKEPGKVHLKSRFIMNGVCVKWRGWIDLERLDGVGCLEFDEERAK 132
 
Name Accession Description Interval E-value
CBF_beta pfam02312
Core binding factor beta subunit; Core binding factor (CBF) is a heterodimeric transcription ...
 1-133 5.92e-86

Core binding factor beta subunit; Core binding factor (CBF) is a heterodimeric transcription factor essential for genetic regulation of hematopoiesis and osteogenesis. The beta subunit enhances DNA-binding ability of the alpha subunit in vitro, and has been show to have a structure related to the OB fold.


Pssm-ID: 396750  Cd Length: 166  Bit Score: 248.81  E-value: 5.92e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238814335    1 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQTRFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQT 80
Cdd:pfam02312   1 MPRVVPDQKSKFESDELFRRLSRESEIKYTGFRDRPHEERQVRFQNGCREGHAEIAFVATGTNLQLQFEPNQTSGTQYHT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 238814335   81 PsREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLHRLDGMGCLEFDEERAQ 133
Cdd:pfam02312  81 P-GEECDFEKEPGKVHLKSRFIMNGVCVKWRGWIDLERLDGVGCLEFDEERAK 132
 
Name Accession Description Interval E-value
CBF_beta pfam02312
Core binding factor beta subunit; Core binding factor (CBF) is a heterodimeric transcription ...
 1-133 5.92e-86

Core binding factor beta subunit; Core binding factor (CBF) is a heterodimeric transcription factor essential for genetic regulation of hematopoiesis and osteogenesis. The beta subunit enhances DNA-binding ability of the alpha subunit in vitro, and has been show to have a structure related to the OB fold.


Pssm-ID: 396750  Cd Length: 166  Bit Score: 248.81  E-value: 5.92e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238814335    1 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQTRFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQT 80
Cdd:pfam02312   1 MPRVVPDQKSKFESDELFRRLSRESEIKYTGFRDRPHEERQVRFQNGCREGHAEIAFVATGTNLQLQFEPNQTSGTQYHT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 238814335   81 PsREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLHRLDGMGCLEFDEERAQ 133
Cdd:pfam02312  81 P-GEECDFEKEPGKVHLKSRFIMNGVCVKWRGWIDLERLDGVGCLEFDEERAK 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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