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Conserved domains on  [gi|240120166|ref|NP_001155281|]
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striatin-4 isoform 2 [Rattus norvegicus]

Protein Classification

striatin( domain architecture ID 10548818)

striatin, a WD40 repeat protein which may function as scaffolding or signaling protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 429-751 2.37e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.17  E-value: 2.37e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 429 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVTMGSNSEYCYSG 508
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 509 GADARIHSWKIPDLNmdpydgydpsvLSCVLEGHGDAVWGLAFSPTSQRLASCSADGTIRIWDPSSSGssclCTFPMAGE 588
Cdd:cd00200   70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK----CLTTLRGH 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 589 HGIPTSVAFTSTEpaHVVASFRSGDTV-LYDLEAGGALLTLEsrGSSGPtqINQVVSHPNQPLTITAHDDRGIRFLDNRT 667
Cdd:cd00200  135 TDWVNSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 668 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 747
Cdd:cd00200  209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                 ....
gi 240120166 748 AKVF 751
Cdd:cd00200  285 IRIW 288
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 64-188 3.11e-40

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


:

Pssm-ID: 462401  Cd Length: 85  Bit Score: 142.26  E-value: 3.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166   64 LPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERakyhklkfgtdlnqg 143
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 240120166  144 ekkadlseqvsngpvesvtldnsplVWKEGRQLLRQYLEEVGYTD 188
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 429-751 2.37e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.17  E-value: 2.37e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 429 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVTMGSNSEYCYSG 508
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 509 GADARIHSWKIPDLNmdpydgydpsvLSCVLEGHGDAVWGLAFSPTSQRLASCSADGTIRIWDPSSSGssclCTFPMAGE 588
Cdd:cd00200   70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK----CLTTLRGH 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 589 HGIPTSVAFTSTEpaHVVASFRSGDTV-LYDLEAGGALLTLEsrGSSGPtqINQVVSHPNQPLTITAHDDRGIRFLDNRT 667
Cdd:cd00200  135 TDWVNSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 668 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 747
Cdd:cd00200  209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                 ....
gi 240120166 748 AKVF 751
Cdd:cd00200  285 IRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
425-750 5.57e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.36  E-value: 5.57e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 425 KTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHRGPVLAVTMGSNSEY 504
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 505 CYSGGADARIHSWKIPDLNmdpydgydpsvLSCVLEGHGDAVWGLAFSPTSQRLASCSADGTIRIWDPSssGSSCLCTFP 584
Cdd:COG2319  177 LASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRTLT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 585 maGEHGIPTSVAFtSTEPAHVVASFRSGDTVLYDLEAGGALLTLESRGSSgptqINQVVSHPNQPLTITAHDDRGIRFLD 664
Cdd:COG2319  244 --GHSGSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG----VNSVAFSPDGKLLASGSDDGTVRLWD 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 665 NRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGA 744
Cdd:COG2319  317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG----HTGAVTSVAFSPDGRTLASGSA 392


                 ....*.
gi 240120166 745 DALAKV 750
Cdd:COG2319  393 DGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 64-188 3.11e-40

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 142.26  E-value: 3.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166   64 LPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERakyhklkfgtdlnqg 143
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 240120166  144 ekkadlseqvsngpvesvtldnsplVWKEGRQLLRQYLEEVGYTD 188
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 532-571 3.55e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 58.48  E-value: 3.55e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 240120166   532 PSVLSCVLEGHGDAVWGLAFSPTSQRLASCSADGTIRIWD 571
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
538-571 3.19e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.81  E-value: 3.19e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 240120166  538 VLEGHGDAVWGLAFSPTSQRLASCSADGTIRIWD 571
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 433-577 1.68e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 433 LRSHYDGIRSLAFHHSQSALL-TASEDGTLKLWNLQKAV---TAKKNAALDVEpihAFRAHRGPVLAVtmgsnseycysG 508
Cdd:PLN00181 571 MKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVsigTIKTKANICCV---QFPSESGRSLAF-----------G 636

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 240120166 509 GADARIHSwkipdlnmdpYDGYDPSVLSCVLEGHGDAVWGLAFSPTSQrLASCSADGTIRIWDPSSSGS 577
Cdd:PLN00181 637 SADHKVYY----------YDLRNPKLPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSIS 694
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 429-751 2.37e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.17  E-value: 2.37e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 429 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVTMGSNSEYCYSG 508
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 509 GADARIHSWKIPDLNmdpydgydpsvLSCVLEGHGDAVWGLAFSPTSQRLASCSADGTIRIWDPSSSGssclCTFPMAGE 588
Cdd:cd00200   70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK----CLTTLRGH 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 589 HGIPTSVAFTSTEpaHVVASFRSGDTV-LYDLEAGGALLTLEsrGSSGPtqINQVVSHPNQPLTITAHDDRGIRFLDNRT 667
Cdd:cd00200  135 TDWVNSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 668 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 747
Cdd:cd00200  209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                 ....
gi 240120166 748 AKVF 751
Cdd:cd00200  285 IRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
425-750 5.57e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.36  E-value: 5.57e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 425 KTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHRGPVLAVTMGSNSEY 504
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 505 CYSGGADARIHSWKIPDLNmdpydgydpsvLSCVLEGHGDAVWGLAFSPTSQRLASCSADGTIRIWDPSssGSSCLCTFP 584
Cdd:COG2319  177 LASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRTLT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 585 maGEHGIPTSVAFtSTEPAHVVASFRSGDTVLYDLEAGGALLTLESRGSSgptqINQVVSHPNQPLTITAHDDRGIRFLD 664
Cdd:COG2319  244 --GHSGSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG----VNSVAFSPDGKLLASGSDDGTVRLWD 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 665 NRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGA 744
Cdd:COG2319  317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG----HTGAVTSVAFSPDGRTLASGSA 392


                 ....*.
gi 240120166 745 DALAKV 750
Cdd:COG2319  393 DGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 416-706 3.10e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 163.66  E-value: 3.10e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 416 LSDSKDAFKKTWN-----PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKavtakknaaldVEPIHAFRAHR 490
Cdd:cd00200   25 ATGSGDGTIKVWDletgeLLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET-----------GECVRTLTGHT 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 491 GPVLAVTMGSNSEYCYSGGADARIHSWKIPDlnmdpydgydpSVLSCVLEGHGDAVWGLAFSPTSQRLASCSADGTIRIW 570
Cdd:cd00200   94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVET-----------GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 571 DPSSSgsSCLCTFPmaGEHGIPTSVAFTSTEPAHVVASfrSGDTV-LYDLEAGGALLTLESRGSSgptqINQVVSHPNQP 649
Cdd:cd00200  163 DLRTG--KCVATLT--GHTGEVNSVAFSPDGEKLLSSS--SDGTIkLWDLSTGKCLGTLRGHENG----VNSVAFSPDGY 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 240120166 650 LTITAHDDRGIRFLDNRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWS 706
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
416-709 7.51e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.16  E-value: 7.51e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 416 LSDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHR 490
Cdd:COG2319  136 ASGSADGTVRLWDLAtgkllRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-----------KLLRTLTGHT 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 491 GPVLAVTMGSNSEYCYSGGADARIHSWkipdlnmDPYDGydpsVLSCVLEGHGDAVWGLAFSPTSQRLASCSADGTIRIW 570
Cdd:COG2319  205 GAVRSVAFSPDGKLLASGSADGTVRLW-------DLATG----KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 571 DPSssGSSCLCTFPmaGEHGIPTSVAFTSTepAHVVASFRSGDTV-LYDLEAGGALLTLESRGSSgptqINQVVSHPNQP 649
Cdd:COG2319  274 DLA--TGELLRTLT--GHSGGVNSVAFSPD--GKLLASGSDDGTVrLWDLATGKLLRTLTGHTGA----VRSVAFSPDGK 343

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 650 LTITAHDDRGIRFLDNRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDN 709
Cdd:COG2319  344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
431-751 2.52e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.22  E-value: 2.52e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 431 FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWnlqkavtakknAALDVEPIHAFRAHRGPVLAVTMGSNSEYCYSGGA 510
Cdd:COG2319   30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLL-----------DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 511 DARIHSWKIpdlnmdpydgyDPSVLSCVLEGHGDAVWGLAFSPTSQRLASCSADGTIRIWDPSSSgsSCLCTFPmaGEHG 590
Cdd:COG2319   99 DGTVRLWDL-----------ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG--KLLRTLT--GHSG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 591 IPTSVAFTSTEpaHVVASFRSGDTV-LYDLEAGGALLTLesRGSSGPtqINQVVSHPNQPLTITAHDDRGIRFLDNRTGK 669
Cdd:COG2319  164 AVTSVAFSPDG--KLLASGSDDGTVrLWDLATGKLLRTL--TGHTGA--VRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 670 SVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAHrkkhEEAIHAVACHPSKALIASAGADALAK 749
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----SGGVNSVAFSPDGKLLASGSDDGTVR 313


                 ..
gi 240120166 750 VF 751
Cdd:COG2319  314 LW 315
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 64-188 3.11e-40

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 142.26  E-value: 3.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166   64 LPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERakyhklkfgtdlnqg 143
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 240120166  144 ekkadlseqvsngpvesvtldnsplVWKEGRQLLRQYLEEVGYTD 188
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 COG2319
WD40 repeat [General function prediction only];
550-751 2.87e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 2.87e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 550 AFSPTSQRLASCSADGTIRIWDPSSSGSSclctfPMAGEHGIPTSVAFTSTEPAHVVASFRSGDTVLYDLEAGGALLTLE 629
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALL-----LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 630 SRGSSgptqINQVVSHPNQPLTITAHDDRGIRFLDNRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDN 709
Cdd:COG2319   76 GHTAA----VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 240120166 710 KTCVQEITAHrkkhEEAIHAVACHPSKALIASAGADALAKVF 751
Cdd:COG2319  152 GKLLRTLTGH----SGAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 532-571 3.55e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 58.48  E-value: 3.55e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 240120166   532 PSVLSCVLEGHGDAVWGLAFSPTSQRLASCSADGTIRIWD 571
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
538-571 3.19e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.81  E-value: 3.19e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 240120166  538 VLEGHGDAVWGLAFSPTSQRLASCSADGTIRIWD 571
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 667-706 1.39e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.39e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 240120166   667 TGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWS 706
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 426-465 2.09e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 2.09e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 240120166   426 TWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWN 465
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
668-706 2.32e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 2.32e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 240120166  668 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWS 706
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
427-465 3.78e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 3.78e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 240120166  427 WNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWN 465
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 433-577 1.68e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240120166 433 LRSHYDGIRSLAFHHSQSALL-TASEDGTLKLWNLQKAV---TAKKNAALDVEpihAFRAHRGPVLAVtmgsnseycysG 508
Cdd:PLN00181 571 MKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVsigTIKTKANICCV---QFPSESGRSLAF-----------G 636

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 240120166 509 GADARIHSwkipdlnmdpYDGYDPSVLSCVLEGHGDAVWGLAFSPTSQrLASCSADGTIRIWDPSSSGS 577
Cdd:PLN00181 637 SADHKVYY----------YDLRNPKLPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSIS 694
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 668-705 1.77e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.21  E-value: 1.77e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 240120166  668 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLW 705
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVW 151
WD40 pfam00400
WD domain, G-beta repeat;
481-517 5.11e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 5.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 240120166  481 EPIHAFRAHRGPVLAVTMGSNSEYCYSGGADARIHSW 517
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 76-129 7.61e-03

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 39.33  E-value: 7.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 240120166   76 ARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERA 129
Cdd:pfam00529  54 TDYQAALDSAEAQLAKAQAQVARLQAELDRLQALESELAISRQDYDGATAQLRA 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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