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Conserved domains on  [gi|253735731|ref|NP_001156715|]
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mitochondrial fission 1 protein isoform 2 [Mus musculus]

Protein Classification

mitochondrial fission 1 protein( domain architecture ID 10187549)

mitochondrial fission 1 (Fis1) protein is an essential protein in mediating mitochondrial fission, and is involved in the fragmentation of the mitochondrial network and its perinuclear clustering; contains tandem Tetratricopeptide repeat (TPR) motifs which are known to mediate protein-protein interactions

CATH:  1.25.40.10
Gene Ontology:  GO:0000266|GO:0060090|GO:0008289|GO:0005515
PubMed:  30708253|10517866
SCOP:  4001344

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fis1 cd12212
Mitochondrial Fission Protein Fis1, cytosolic domain; Fis1, along with Dnm1 and Mdv1, is an ...
 4-116 1.73e-52

Mitochondrial Fission Protein Fis1, cytosolic domain; Fis1, along with Dnm1 and Mdv1, is an essential protein in mediating mitochondrial fission. Dnm1 and Fis1 are highly conserved, with a common mechanism in disparate species. In mutants of these proteins, mitochondrial fission is impaired, resulting in networks of undivided mitochondria. The Fis1 N-terminus is cytosolic and tethered to the mitochondrial outer membrane via a C-terminal transmembrane domain. Fis1 appears to act via the recruitment of division complexes to the mitochondrial outer membrane, via interactions with Mdv1 or Caf4. Fis1 has tandem Tetratricopeptide repeat (TPR) motifs which are known to mediate protein-protein interactions.


:

Pssm-ID: 276936 [Multi-domain]  Cd Length: 115  Bit Score: 161.95  E-value: 1.73e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735731   4 DEAARNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNEDIRRGIVLLEELLpKGSKEEQRDYVFYLAVGNYRLKEYEKA 83
Cdd:cd12212    4 PEELAVLEEQYNSELARGSVSPQTQFNYAWALVKSKNPEDIRRGIELLEELY-RDGPERRRECLYYLALGHYKLGEYSEA 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 253735731  84 LKYVRGLLQTEPQNNQAKELERLIDKAMKKDGL 116
Cdd:cd12212   83 RRYVDALLEIEPDNRQALALKELIEDKITKEGL 115
 
Name Accession Description Interval E-value
Fis1 cd12212
Mitochondrial Fission Protein Fis1, cytosolic domain; Fis1, along with Dnm1 and Mdv1, is an ...
 4-116 1.73e-52

Mitochondrial Fission Protein Fis1, cytosolic domain; Fis1, along with Dnm1 and Mdv1, is an essential protein in mediating mitochondrial fission. Dnm1 and Fis1 are highly conserved, with a common mechanism in disparate species. In mutants of these proteins, mitochondrial fission is impaired, resulting in networks of undivided mitochondria. The Fis1 N-terminus is cytosolic and tethered to the mitochondrial outer membrane via a C-terminal transmembrane domain. Fis1 appears to act via the recruitment of division complexes to the mitochondrial outer membrane, via interactions with Mdv1 or Caf4. Fis1 has tandem Tetratricopeptide repeat (TPR) motifs which are known to mediate protein-protein interactions.


Pssm-ID: 276936 [Multi-domain]  Cd Length: 115  Bit Score: 161.95  E-value: 1.73e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735731   4 DEAARNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNEDIRRGIVLLEELLpKGSKEEQRDYVFYLAVGNYRLKEYEKA 83
Cdd:cd12212    4 PEELAVLEEQYNSELARGSVSPQTQFNYAWALVKSKNPEDIRRGIELLEELY-RDGPERRRECLYYLALGHYKLGEYSEA 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 253735731  84 LKYVRGLLQTEPQNNQAKELERLIDKAMKKDGL 116
Cdd:cd12212   83 RRYVDALLEIEPDNRQALALKELIEDKITKEGL 115
Fis1_TPR_C pfam14853
Fis1 C-terminal tetratricopeptide repeat; The mitochondrial fission protein Fis1 consists of ...
 64-116 1.79e-23

Fis1 C-terminal tetratricopeptide repeat; The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This domain is the C-terminal tetratricopeptide repeat


Pssm-ID: 434269 [Multi-domain]  Cd Length: 53  Bit Score: 86.42  E-value: 1.79e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 253735731   64 RDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGL 116
Cdd:pfam14853   1 RECLYYLAVGHYKLGEYSEARRYVDALLEIEPDNRQALALKELIEDKITKEGL 53
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 28-110 3.71e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 35.37  E-value: 3.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735731  28 QFEYAWCLVRSkynEDIRRGIVLLEELLPKGSKEEQrdYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLI 107
Cdd:COG4235   54 LLDLAEALLAA---GDTEEAEELLERALALDPDNPE--ALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASI 128


                 ...
gi 253735731 108 DKA 110
Cdd:COG4235  129 AEA 131
 
Name Accession Description Interval E-value
Fis1 cd12212
Mitochondrial Fission Protein Fis1, cytosolic domain; Fis1, along with Dnm1 and Mdv1, is an ...
 4-116 1.73e-52

Mitochondrial Fission Protein Fis1, cytosolic domain; Fis1, along with Dnm1 and Mdv1, is an essential protein in mediating mitochondrial fission. Dnm1 and Fis1 are highly conserved, with a common mechanism in disparate species. In mutants of these proteins, mitochondrial fission is impaired, resulting in networks of undivided mitochondria. The Fis1 N-terminus is cytosolic and tethered to the mitochondrial outer membrane via a C-terminal transmembrane domain. Fis1 appears to act via the recruitment of division complexes to the mitochondrial outer membrane, via interactions with Mdv1 or Caf4. Fis1 has tandem Tetratricopeptide repeat (TPR) motifs which are known to mediate protein-protein interactions.


Pssm-ID: 276936 [Multi-domain]  Cd Length: 115  Bit Score: 161.95  E-value: 1.73e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735731   4 DEAARNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNEDIRRGIVLLEELLpKGSKEEQRDYVFYLAVGNYRLKEYEKA 83
Cdd:cd12212    4 PEELAVLEEQYNSELARGSVSPQTQFNYAWALVKSKNPEDIRRGIELLEELY-RDGPERRRECLYYLALGHYKLGEYSEA 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 253735731  84 LKYVRGLLQTEPQNNQAKELERLIDKAMKKDGL 116
Cdd:cd12212   83 RRYVDALLEIEPDNRQALALKELIEDKITKEGL 115
Fis1_TPR_C pfam14853
Fis1 C-terminal tetratricopeptide repeat; The mitochondrial fission protein Fis1 consists of ...
 64-116 1.79e-23

Fis1 C-terminal tetratricopeptide repeat; The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This domain is the C-terminal tetratricopeptide repeat


Pssm-ID: 434269 [Multi-domain]  Cd Length: 53  Bit Score: 86.42  E-value: 1.79e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 253735731   64 RDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGL 116
Cdd:pfam14853   1 RECLYYLAVGHYKLGEYSEARRYVDALLEIEPDNRQALALKELIEDKITKEGL 53
Fis1_TPR_N pfam14852
Fis1 N-terminal tetratricopeptide repeat; The mitochondrial fission protein Fis1 consists of ...
 27-55 9.03e-13

Fis1 N-terminal tetratricopeptide repeat; The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This domain is the N-terminal tetratricopeptide repeat


Pssm-ID: 464348  Cd Length: 33  Bit Score: 58.56  E-value: 9.03e-13
                          10        20
                  ....*....|....*....|....*....
gi 253735731   27 TQFEYAWCLVRSKYNEDIRRGIVLLEELL 55
Cdd:pfam14852   2 TKFNYAWALVKSKNRADQQRGIALLEELY 30
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 28-110 3.71e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 35.37  E-value: 3.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 253735731  28 QFEYAWCLVRSkynEDIRRGIVLLEELLPKGSKEEQrdYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLI 107
Cdd:COG4235   54 LLDLAEALLAA---GDTEEAEELLERALALDPDNPE--ALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASI 128


                 ...
gi 253735731 108 DKA 110
Cdd:COG4235  129 AEA 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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