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Conserved domains on  [gi|254028195|ref|NP_001156783|]
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serine racemase isoform 1 [Mus musculus]

Protein Classification

PALP domain-containing protein( domain architecture ID 751)

PALP domain-containing protein belonging to the tryptophan synthase beta superfamily (fold type II) that consists of pyridoxal phosphate (PLP)-dependent enzymes that catalyze beta-replacement and beta-elimination reactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Trp-synth-beta_II super family cl00342
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ...
 5-322 1.45e-144

Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.


The actual alignment was detected with superfamily member PLN02970:

Pssm-ID: 444852 [Multi-domain]  Cd Length: 328  Bit Score: 411.38  E-value: 1.45e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   5 YCISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTPEekpKAVVTHSS 84
Cdd:PLN02970   7 YAADLSSIREARKRIAPFIHRTPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGACNAIFSLSDDQAE---KGVVTHSS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  85 GNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQG 164
Cdd:PLN02970  84 GNHAAALALAAKLRGIPAYIVVPKNAPACKVDAVIRYGGIITWCEPTVESREAVAARVQQETGAVLIHPYNDGRVISGQG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 165 TIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHpPETIADGVKSSI 244
Cdd:PLN02970 164 TIALEFLEQVPELDVIIVPISGGGLISGIALAAKAIKPSIKIIAAEPKGADDAAQSKAAGEIITLPV-TNTIADGLRASL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 245 GLNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSP--EVKNVCIVLSGGNVDLTSL 322
Cdd:PLN02970 243 GDLTWPVVRDLVDDVITVDDKEIIEAMKLCYERLKVVVEPSGAIGLAAALSDSFRSNPAwkGCKNVGIVLSGGNVDLGVL 322
 
Name Accession Description Interval E-value
PLN02970 PLN02970
serine racemase
 5-322 1.45e-144

serine racemase


Pssm-ID: 215524 [Multi-domain]  Cd Length: 328  Bit Score: 411.38  E-value: 1.45e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   5 YCISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTPEekpKAVVTHSS 84
Cdd:PLN02970   7 YAADLSSIREARKRIAPFIHRTPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGACNAIFSLSDDQAE---KGVVTHSS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  85 GNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQG 164
Cdd:PLN02970  84 GNHAAALALAAKLRGIPAYIVVPKNAPACKVDAVIRYGGIITWCEPTVESREAVAARVQQETGAVLIHPYNDGRVISGQG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 165 TIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHpPETIADGVKSSI 244
Cdd:PLN02970 164 TIALEFLEQVPELDVIIVPISGGGLISGIALAAKAIKPSIKIIAAEPKGADDAAQSKAAGEIITLPV-TNTIADGLRASL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 245 GLNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSP--EVKNVCIVLSGGNVDLTSL 322
Cdd:PLN02970 243 GDLTWPVVRDLVDDVITVDDKEIIEAMKLCYERLKVVVEPSGAIGLAAALSDSFRSNPAwkGCKNVGIVLSGGNVDLGVL 322
Thr-dehyd cd01562
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ...
 9-318 5.99e-125

Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.


Pssm-ID: 107205 [Multi-domain]  Cd Length: 304  Bit Score: 360.26  E-value: 5.99e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   9 FADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHG 88
Cdd:cd01562    1 LEDILAAAARIKPVVRRTPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAYNKLLSL---SEEERAKGVVAASAGNHA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  89 QALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTIAL 168
Cdd:cd01562   78 QGVAYAAKLLGIPATIVMPETAPAAKVDATRAYGAEVVLYGEDFDEAEAKARELAEEEGLTFIHPFDDPDVIAGQGTIGL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 169 EVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPeTIADGVK-SSIGLN 247
Cdd:cd01562  158 EILEQVPDLDAVFVPVGGGGLIAGIATAVKALSPNTKVIGVEPEGAPAMAQSLAAGKPVTLPEVD-TIADGLAvKRPGEL 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254028195 248 TWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQtvsPEVKNVCIVLSGGNVD 318
Cdd:cd01562  237 TFEIIRKLVDDVVTVSEDEIAAAMLLLFEREKLVAEPAGALALAALLSGKLD---LKGKKVVVVLSGGNID 304
IlvA COG1171
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ...
 7-325 6.07e-109

Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440784 [Multi-domain]  Cd Length: 327  Bit Score: 320.45  E-value: 6.07e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:COG1171    6 PTLADIEAAAARIAGVVRRTPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALASL---SEEERARGVVAASAGN 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTI 166
Cdd:COG1171   83 HAQGVAYAARLLGIPATIVMPETAPAVKVAATRAYGAEVVLHGDTYDDAEAAAAELAEEEGATFVHPFDDPDVIAGQGTI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 167 ALEVLNQVPLVDALvvpvggggmvagIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVK-SSIG 245
Cdd:COG1171  163 ALEILEQLPDLDAVfvpvggggliagVAAALKALSPDIRVIGVEPEGAAAMYRSLAAGEPVT-LPGVDTIADGLAvGRPG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 246 LNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQtvsPEVKNVCIVLSGGNVDLTSLNWV 325
Cdd:COG1171  242 ELTFEILRDLVDDIVTVSEDEIAAAMRLLLERTKIVVEPAGAAALAALLAGKER---LKGKRVVVVLSGGNIDPDRLAEI 318
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 19-314 1.82e-73

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 229.12  E-value: 1.82e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   19 IQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPdtpEEKPKAVVTHSSGNHGQALTYAAKLE 98
Cdd:pfam00291   1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKE---GEGGKTVVEASSGNHGRALAAAAARL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   99 GIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEG-ILVHPNQEPAVIAGQGTIALEVLNQV-PL 176
Cdd:pfam00291  78 GLKVTIVVPEDAPPGKLLLMRALGAEVVLVGGDYDEAVAAARELAAEGPGaYYINQYDNPLNIEGYGTIGLEILEQLgGD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  177 VDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVKSSI--GLNTWPIIRD 254
Cdd:pfam00291 158 PDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSLAAGRPVP-VPVADTIADGLGVGDepGALALDLLDE 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  255 LVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSPEvKNVCIVLSG 314
Cdd:pfam00291 237 YVGEVVTVSDEEALEAMRLLARREGIVVEPSSAAALAALKLALAGELKGG-DRVVVVLTG 295
ilvA_1Cterm TIGR01127
threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the ...
 26-325 3.02e-67

threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the C-terminal domain pfam00585 is described by TIGR01124. This model describes a phylogenetically distinct form with a single copy of pfam00585. This form branches with the catabolic threonine dehydratase of E. coli; many members are designated as catabolic for this reason. However, the catabolic form lacks any pfam00585 domain. Many members of this model are found in species with other Ile biosynthetic enzymes. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130197 [Multi-domain]  Cd Length: 380  Bit Score: 215.76  E-value: 3.02e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIV 105
Cdd:TIGR01127   1 TPLIYSTTLSDITGSEVYLKLENLQKTGSFKIRGALNKIANL---SEDQRQRGVVAASAGNHAQGVAYAAKKFGIKAVIV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  106 VPQTAPNCKKLAIQAYGASIV-YCDPSDESREKVTqRIMQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPV 184
Cdd:TIGR01127  78 MPESAPPSKVKATKSYGAEVIlHGDDYDEAYAFAT-SLAEEEGRVFVHPFDDEFVMAGQGTIGLEIMEDIPDVDTVIVPV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  185 GGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPeTIADGVK-SSIGLNTWPIIRDLVDDVFTVT 263
Cdd:TIGR01127 157 GGGGLISGVASAAKQINPNVKVIGVEAEGAPSMYESLREGKIKAVESVR-TIADGIAvKKPGDLTFNIIKEYVDDVVTVD 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254028195  264 EDEIKYATQLVWGRMKLLIEPTAGVALAAVLSqhfQTVSPEVKNVCIVLSGGNVDLTSLNWV 325
Cdd:TIGR01127 236 EEEIANAIYLLLERHKILAEGAGAAGVAALLE---QKVDVKGKKIAVVLSGGNIDLNLLNKI 294
 
Name Accession Description Interval E-value
PLN02970 PLN02970
serine racemase
 5-322 1.45e-144

serine racemase


Pssm-ID: 215524 [Multi-domain]  Cd Length: 328  Bit Score: 411.38  E-value: 1.45e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   5 YCISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTPEekpKAVVTHSS 84
Cdd:PLN02970   7 YAADLSSIREARKRIAPFIHRTPVLTSSSLDALAGRSLFFKCECFQKGGAFKFRGACNAIFSLSDDQAE---KGVVTHSS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  85 GNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQG 164
Cdd:PLN02970  84 GNHAAALALAAKLRGIPAYIVVPKNAPACKVDAVIRYGGIITWCEPTVESREAVAARVQQETGAVLIHPYNDGRVISGQG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 165 TIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHpPETIADGVKSSI 244
Cdd:PLN02970 164 TIALEFLEQVPELDVIIVPISGGGLISGIALAAKAIKPSIKIIAAEPKGADDAAQSKAAGEIITLPV-TNTIADGLRASL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 245 GLNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSP--EVKNVCIVLSGGNVDLTSL 322
Cdd:PLN02970 243 GDLTWPVVRDLVDDVITVDDKEIIEAMKLCYERLKVVVEPSGAIGLAAALSDSFRSNPAwkGCKNVGIVLSGGNVDLGVL 322
Thr-dehyd cd01562
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ...
 9-318 5.99e-125

Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.


Pssm-ID: 107205 [Multi-domain]  Cd Length: 304  Bit Score: 360.26  E-value: 5.99e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   9 FADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHG 88
Cdd:cd01562    1 LEDILAAAARIKPVVRRTPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAYNKLLSL---SEEERAKGVVAASAGNHA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  89 QALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTIAL 168
Cdd:cd01562   78 QGVAYAAKLLGIPATIVMPETAPAAKVDATRAYGAEVVLYGEDFDEAEAKARELAEEEGLTFIHPFDDPDVIAGQGTIGL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 169 EVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPeTIADGVK-SSIGLN 247
Cdd:cd01562  158 EILEQVPDLDAVFVPVGGGGLIAGIATAVKALSPNTKVIGVEPEGAPAMAQSLAAGKPVTLPEVD-TIADGLAvKRPGEL 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254028195 248 TWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQtvsPEVKNVCIVLSGGNVD 318
Cdd:cd01562  237 TFEIIRKLVDDVVTVSEDEIAAAMLLLFEREKLVAEPAGALALAALLSGKLD---LKGKKVVVVLSGGNID 304
IlvA COG1171
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ...
 7-325 6.07e-109

Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440784 [Multi-domain]  Cd Length: 327  Bit Score: 320.45  E-value: 6.07e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:COG1171    6 PTLADIEAAAARIAGVVRRTPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALASL---SEEERARGVVAASAGN 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTI 166
Cdd:COG1171   83 HAQGVAYAARLLGIPATIVMPETAPAVKVAATRAYGAEVVLHGDTYDDAEAAAAELAEEEGATFVHPFDDPDVIAGQGTI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 167 ALEVLNQVPLVDALvvpvggggmvagIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVK-SSIG 245
Cdd:COG1171  163 ALEILEQLPDLDAVfvpvggggliagVAAALKALSPDIRVIGVEPEGAAAMYRSLAAGEPVT-LPGVDTIADGLAvGRPG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 246 LNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQtvsPEVKNVCIVLSGGNVDLTSLNWV 325
Cdd:COG1171  242 ELTFEILRDLVDDIVTVSEDEIAAAMRLLLERTKIVVEPAGAAALAALLAGKER---LKGKRVVVVLSGGNIDPDRLAEI 318
PRK07048 PRK07048
threo-3-hydroxy-L-aspartate ammonia-lyase;
7-320 2.34e-99

threo-3-hydroxy-L-aspartate ammonia-lyase;


Pssm-ID: 235918 [Multi-domain]  Cd Length: 321  Bit Score: 296.16  E-value: 2.34e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:PRK07048   6 PTYDDVAAAAARLAGVAHRTPVLTSRTADARTGAQVFFKCENFQRMGAFKFRGAYNALSQF---SPEQRRAGVVTFSSGN 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTI 166
Cdd:PRK07048  83 HAQAIALSARLLGIPATIVMPQDAPAAKVAATRGYGGEVVTYDRYTEDREEIGRRLAEERGLTLIPPYDHPHVIAGQGTA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 167 ALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTpNLHPPETIADGVKS-SIG 245
Cdd:PRK07048 163 AKELFEEVGPLDALFVCLGGGGLLSGCALAARALSPGCKVYGVEPEAGNDGQQSFRSGEIV-HIDTPRTIADGAQTqHLG 241

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254028195 246 LNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSqhfQTVSPEVKNVCIVLSGGNVDLT 320
Cdd:PRK07048 242 NYTFPIIRRLVDDIVTVSDAELVDAMRFFAERMKIVVEPTGCLGAAAALR---GKVPLKGKRVGVIISGGNVDLA 313
PRK06608 PRK06608
serine/threonine dehydratase;
8-323 6.85e-78

serine/threonine dehydratase;


Pssm-ID: 235842 [Multi-domain]  Cd Length: 338  Bit Score: 241.98  E-value: 6.85e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   8 SFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDtpEEKPKAVVTHSSGNH 87
Cdd:PRK06608   6 NPQNIAAAHNRIKQYLHLTPIVHSESLNEMLGHEIFFKVESLQKTGAFKVRGVLNHLLELKEQ--GKLPDKIVAYSTGNH 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  88 GQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGIlvHPNQEPAVIAGQGTIA 167
Cdd:PRK06608  84 GQAVAYASKLFGIKTRIYLPLNTSKVKQQAALYYGGEVILTNTRQEAEEKAKEDEEQGFYYI--HPSDSDSTIAGAGTLC 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 168 LEVLNQVPL-VDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIADGVKS-SIG 245
Cdd:PRK06608 162 YEALQQLGFsPDAIFASCGGGGLISGTYLAKELISPTSLLIGSEPLNANDAYLSLKNNKIYRLNYSPNTIADGLKTlSVS 241

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254028195 246 LNTWPIIRDLvDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSPevKNVCIVLSGGNVDLTSLN 323
Cdd:PRK06608 242 ARTFEYLKKL-DDFYLVEEYEIYYWTAWLTHLLKVICEPSSAINMVAVVNWLKTQSKP--QKLLVILSGGNIDPILYN 316
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 19-314 1.82e-73

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 229.12  E-value: 1.82e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   19 IQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPdtpEEKPKAVVTHSSGNHGQALTYAAKLE 98
Cdd:pfam00291   1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKE---GEGGKTVVEASSGNHGRALAAAAARL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   99 GIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEG-ILVHPNQEPAVIAGQGTIALEVLNQV-PL 176
Cdd:pfam00291  78 GLKVTIVVPEDAPPGKLLLMRALGAEVVLVGGDYDEAVAAARELAAEGPGaYYINQYDNPLNIEGYGTIGLEILEQLgGD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  177 VDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVKSSI--GLNTWPIIRD 254
Cdd:pfam00291 158 PDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARSLAAGRPVP-VPVADTIADGLGVGDepGALALDLLDE 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  255 LVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSPEvKNVCIVLSG 314
Cdd:pfam00291 237 YVGEVVTVSDEEALEAMRLLARREGIVVEPSSAAALAALKLALAGELKGG-DRVVVVLTG 295
PRK06815 PRK06815
threonine/serine dehydratase;
9-322 5.84e-69

threonine/serine dehydratase;


Pssm-ID: 180709 [Multi-domain]  Cd Length: 317  Bit Score: 218.41  E-value: 5.84e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   9 FADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHG 88
Cdd:PRK06815   4 FDAILEAHQRLRPQVRVTPLEHSPLLSQHTGCEVYLKCEHLQHTGSFKFRGASNKLRLL---NEAQRQQGVITASSGNHG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  89 QALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTIAL 168
Cdd:PRK06815  81 QGVALAAKLAGIPVTVYAPEQASAIKLDAIRALGAEVRLYGGDALNAELAARRAAEQQGKVYISPYNDPQVIAGQGTIGM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 169 EVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVKSSI--GL 246
Cdd:PRK06815 161 ELVEQQPDLDAVFVAVGGGGLISGIATYLKTLSPKTEIIGCWPANSPSLYTSLEAGEIVE-VAEQPTLSDGTAGGVepGA 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254028195 247 NTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQhfqtvSPEV--KNVCIVLSGGNVDLTSL 322
Cdd:PRK06815 240 ITFPLCQQLIDQKVLVSEEEIKEAMRLIAETDRWLIEGAAGVALAAALKL-----APRYqgKKVAVVLCGKNIVLEKY 312
ilvA_1Cterm TIGR01127
threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the ...
 26-325 3.02e-67

threonine ammonia-lyase, medium form; A form of threonine dehydratase with two copies of the C-terminal domain pfam00585 is described by TIGR01124. This model describes a phylogenetically distinct form with a single copy of pfam00585. This form branches with the catabolic threonine dehydratase of E. coli; many members are designated as catabolic for this reason. However, the catabolic form lacks any pfam00585 domain. Many members of this model are found in species with other Ile biosynthetic enzymes. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130197 [Multi-domain]  Cd Length: 380  Bit Score: 215.76  E-value: 3.02e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIV 105
Cdd:TIGR01127   1 TPLIYSTTLSDITGSEVYLKLENLQKTGSFKIRGALNKIANL---SEDQRQRGVVAASAGNHAQGVAYAAKKFGIKAVIV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  106 VPQTAPNCKKLAIQAYGASIV-YCDPSDESREKVTqRIMQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPV 184
Cdd:TIGR01127  78 MPESAPPSKVKATKSYGAEVIlHGDDYDEAYAFAT-SLAEEEGRVFVHPFDDEFVMAGQGTIGLEIMEDIPDVDTVIVPV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  185 GGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPeTIADGVK-SSIGLNTWPIIRDLVDDVFTVT 263
Cdd:TIGR01127 157 GGGGLISGVASAAKQINPNVKVIGVEAEGAPSMYESLREGKIKAVESVR-TIADGIAvKKPGDLTFNIIKEYVDDVVTVD 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254028195  264 EDEIKYATQLVWGRMKLLIEPTAGVALAAVLSqhfQTVSPEVKNVCIVLSGGNVDLTSLNWV 325
Cdd:TIGR01127 236 EEEIANAIYLLLERHKILAEGAGAAGVAALLE---QKVDVKGKKIAVVLSGGNIDLNLLNKI 294
PRK08638 PRK08638
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
7-320 1.68e-65

bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;


Pssm-ID: 236317 [Multi-domain]  Cd Length: 333  Bit Score: 209.98  E-value: 1.68e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:PRK08638   9 VAIDDIIEAKQRLAGRIRKTPLPRSNYLSERCKGEIFLKLENMQRTGSFKIRGAFNKLSSL---TDAEKRKGVVACSAGN 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIV-YCDPSDESREKVTQRImqETEG-ILVHPNQEPAVIAGQG 164
Cdd:PRK08638  86 HAQGVALSCALLGIDGKVVMPKGAPKSKVAATCGYGAEVVlHGDNFNDTIAKVEEIV--EEEGrTFIPPYDDPKVIAGQG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 165 TIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPeTIADGVKSSI 244
Cdd:PRK08638 164 TIGLEILEDLWDVDTVIVPIGGGGLIAGIAVALKSINPTIHIIGVQSENVHGMAASFYAGEITTHRTTG-TLADGCDVSR 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254028195 245 -GLNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSPEVKNVCIVlSGGNVDLT 320
Cdd:PRK08638 243 pGNLTYEIVRELVDDIVLVSEDEIRNAMKDLIQRNKVVTEGAGALATAALLSGKLDQYIQNKKVVAII-SGGNVDLS 318
PRK07334 PRK07334
threonine dehydratase; Provisional
 7-318 1.39e-60

threonine dehydratase; Provisional


Pssm-ID: 235994 [Multi-domain]  Cd Length: 403  Bit Score: 199.35  E-value: 1.39e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:PRK07334   5 VTLADIRAAAARLAGQVLRTPCVHSRTLSQITGAEVWLKFENLQFTASFKERGALNKLLLL---TEEERARGVIAMSAGN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIV-YCDPSDESREkvTQRIMQETEG-ILVHPNQEPAVIAGQG 164
Cdd:PRK07334  82 HAQGVAYHAQRLGIPATIVMPRFTPTVKVERTRGFGAEVVlHGETLDEARA--HARELAEEEGlTFVHPYDDPAVIAGQG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 165 TIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQsKLKGELTPNLHppETIADG--VKs 242
Cdd:PRK07334 160 TVALEMLEDAPDLDTLVVPIGGGGLISGMATAAKALKPDIEIIGVQTELYPSMYA-AIKGVALPCGG--STIAEGiaVK- 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 243 SIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVwgrmkLLIEPT----AGVA-LAAVLS--QHFQTvspevKNVCIVLSGG 315
Cdd:PRK07334 236 QPGQLTLEIVRRLVDDILLVSEADIEQAVSLL-----LEIEKTvvegAGAAgLAALLAypERFRG-----RKVGLVLSGG 305


                 ...
gi 254028195 316 NVD 318
Cdd:PRK07334 306 NID 308
eutB PRK07476
threonine dehydratase; Provisional
 7-319 2.94e-56

threonine dehydratase; Provisional


Pssm-ID: 236025 [Multi-domain]  Cd Length: 322  Bit Score: 185.55  E-value: 2.94e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:PRK07476   1 VSLADIYRARRRIAGRVRRTPLVASASLSARAGVPVWLKLETLQPTGSFKLRGATNALLSL---SAQERARGVVTASTGN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPS-DESREKVtQRIMQETEGILVHPNQEPAVIAGQGT 165
Cdd:PRK07476  78 HGRALAYAARALGIRATICMSRLVPANKVDAIRALGAEVRIVGRSqDDAQAEV-ERLVREEGLTMVPPFDDPRIIAGQGT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 166 IALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGeltpnlHP-----PETIADGV 240
Cdd:PRK07476 157 IGLEILEALPDVATVLVPLSGGGLASGVAAAVKAIRPAIRVIGVSMERGAAMHASLAAG------RPvqveeVPTLADSL 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 241 KSSIGLN---TWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSqhfQTVSPEVKNVCIVLSGGNV 317
Cdd:PRK07476 231 GGGIGLDnryTFAMCRALLDDVVLLDEAEIAAGIRHAYREERLVVEGAGAVGIAALLA---GKIAARDGPIVVVVSGANI 307


                 ..
gi 254028195 318 DL 319
Cdd:PRK07476 308 DM 309
Trp-synth-beta_II cd00640
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ...
 26-315 2.00e-53

Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.


Pssm-ID: 107202 [Multi-domain]  Cd Length: 244  Bit Score: 175.78  E-value: 2.00e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDtpEEKPKAVVTH-SSGNHGQALTYAAKLEGIPAYI 104
Cdd:cd00640    1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEE--GKLPKGVIIEsTGGNTGIALAAAAARLGLKCTI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 105 VVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEG-ILVHPNQEPAVIAGQGTIALEVLNQVP--LVDALV 181
Cdd:cd00640   79 VMPEGASPEKVAQMRALGAEVVLVPGDFDDAIALAKELAEEDPGaYYVNQFDNPANIAGQGTIGLEILEQLGgqKPDAVV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 182 VPVGGGGMVAGIAITIKALKPSVKVYAAEPsnaddcyqsklkgeltpnlhppetiadgvkssiglntwpiirdlvdDVFT 261
Cdd:cd00640  159 VPVGGGGNIAGIARALKELLPNVKVIGVEP----------------------------------------------EVVT 192

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 254028195 262 VTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTvsPEVKNVCIVLSGG 315
Cdd:cd00640  193 VSDEEALEAIRLLAREEGILVEPSSAAALAAALKLAKKL--GKGKTVVVILTGG 244
PRK08246 PRK08246
serine/threonine dehydratase;
7-323 7.81e-53

serine/threonine dehydratase;


Pssm-ID: 181319 [Multi-domain]  Cd Length: 310  Bit Score: 176.30  E-value: 7.81e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   7 ISFADVEKAHINIQDSIHLTPVLTSSIlNQIAGRNLFFKCELFQKTGSFKIRGALNAIRglipdTPEEKPKAVVTHSSGN 86
Cdd:PRK08246   5 ITRSDVRAAAQRIAPHIRRTPVLEADG-AGFGPAPVWLKLEHLQHTGSFKARGAFNRLL-----AAPVPAAGVVAASGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTI 166
Cdd:PRK08246  79 AGLAVAYAAAALGVPATVFVPETAPPAKVARLRALGAEVVVVGAEYADALEAAQAFAAETGALLCHAYDQPEVLAGAGTL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 167 ALEVLNQVPLVDALVVPVGGGGMVAGIAitiKALKPSVKVYAAEPSNADDCYQSKLKGEltpnlhPPETIADGVKSS--- 243
Cdd:PRK08246 159 GLEIEEQAPGVDTVLVAVGGGGLIAGIA---AWFEGRARVVAVEPEGAPTLHAALAAGE------PVDVPVSGIAADslg 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 244 ---IGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSPEvkNVCIVLSGGNVDLT 320
Cdd:PRK08246 230 arrVGEIAFALARAHVVTSVLVSDEAIIAARRALWEELRLAVEPGAATALAALLSGAYVPAPGE--RVAVVLCGANTDPA 307


                 ...
gi 254028195 321 SLN 323
Cdd:PRK08246 308 TLA 310
ectoine_eutB TIGR02991
ectoine utilization protein EutB; Members of this protein family are EutB, a predicted ...
 7-319 2.92e-47

ectoine utilization protein EutB; Members of this protein family are EutB, a predicted arylmalonate decarboxylase found in a conserved ectoine utilization operon of species that include Sinorhizobium meliloti 1021 (where it is known to be induced by ectoine), Mesorhizobium loti, Silicibacter pomeroyi, Agrobacterium tumefaciens, and Pseudomonas putida. Members of this family resemble threonine dehydratases.


Pssm-ID: 132036 [Multi-domain]  Cd Length: 317  Bit Score: 161.94  E-value: 2.92e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195    7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:TIGR02991   1 VTLQDIERAAARISGRVEETPLVESPSLSELCGVPVHLKLEHRQTTGSFKLRGATNAVLSL---SDTQRAAGVVAASTGN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASI-VYCDPSDESREKVtQRIMQETEGILVHPNQEPAVIAGQGT 165
Cdd:TIGR02991  78 HGRALAYAAAEEGVRATICMSELVPQNKVDEIRRLGAEVrIVGRSQDDAQEEV-ERLVADRGLTMLPPFDHPDIVAGQGT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  166 IALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSkLKGELTPNLHPPETIADGVKSSIG 245
Cdd:TIGR02991 157 LGLEVVEQMPDLATVLVPLSGGGLASGVAMAVKAARPDTRVIGVSMERGAAMKAS-LQAGRPVLVAELPTLADSLGGGIG 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254028195  246 LN---TWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSPEVknvcIVLSGGNVDL 319
Cdd:TIGR02991 236 LDnrvTFAMCKALLDEIVLVSEAEIAAGIRHAYAEEREIVEGAGAVGIAALLAGKIKNPGPCA----VIVSGRNIDM 308
PRK09224 PRK09224
threonine ammonia-lyase IlvA;
39-330 1.26e-43

threonine ammonia-lyase IlvA;


Pssm-ID: 236417 [Multi-domain]  Cd Length: 504  Bit Score: 156.84  E-value: 1.26e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  39 GRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAI 118
Cdd:PRK09224  34 GNQVLLKREDLQPVFSFKLRGAYNKMAQL---TEEQLARGVITASAGNHAQGVALSAARLGIKAVIVMPVTTPDIKVDAV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 119 QAYGASIV-YCDPSDESREKvTQRIMQETEGILVHPNQEPAVIAGQGTIALEVLNQVP-LVDALVVPVGGGGMVAGIAIT 196
Cdd:PRK09224 111 RAFGGEVVlHGDSFDEAYAH-AIELAEEEGLTFIHPFDDPDVIAGQGTIAMEILQQHPhPLDAVFVPVGGGGLIAGVAAY 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 197 IKALKPSVKVYAAEPSNADDCYQSKLKGELTpNLHPPETIADG--VKsSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLV 274
Cdd:PRK09224 190 IKQLRPEIKVIGVEPEDSACLKAALEAGERV-DLPQVGLFADGvaVK-RIGEETFRLCQEYVDDVITVDTDEICAAIKDV 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 254028195 275 WGRMKLLIEPTAGVALAAvLSQHFQTVSPEVKNVCIVLSGGNVDLTSLNWVgqAER 330
Cdd:PRK09224 268 FEDTRSIAEPAGALALAG-LKKYVAQHGIEGETLVAILSGANMNFDRLRYV--AER 320
PRK12483 PRK12483
threonine dehydratase; Reviewed
 26-330 3.12e-41

threonine dehydratase; Reviewed


Pssm-ID: 237111 [Multi-domain]  Cd Length: 521  Bit Score: 150.72  E-value: 3.12e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIV 105
Cdd:PRK12483  38 TPLQRAPNLSARLGNQVLLKREDLQPVFSFKIRGAYNKMARL---PAEQLARGVITASAGNHAQGVALAAARLGVKAVIV 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 106 VPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTIALEVLNQVP-LVDALVVPV 184
Cdd:PRK12483 115 MPRTTPQLKVDGVRAHGGEVVLHGESFPDALAHALKLAEEEGLTFVPPFDDPDVIAGQGTVAMEILRQHPgPLDAIFVPV 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 185 GGGGMVAGIAITIKALKPSVKVYAAEPSNAdDCYQSKLKGELTPNLHPPETIADGVK-SSIGLNTWPIIRDLVDDVFTVT 263
Cdd:PRK12483 195 GGGGLIAGIAAYVKYVRPEIKVIGVEPDDS-NCLQAALAAGERVVLGQVGLFADGVAvAQIGEHTFELCRHYVDEVVTVS 273

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254028195 264 EDEIKYATQLVWGRMKLLIEPTAGVALAAvLSQHFQTVSPEVKNVCIVLSGGNVDLTSLNWVgqAER 330
Cdd:PRK12483 274 TDELCAAIKDIYDDTRSITEPAGALAVAG-IKKYAEREGIEGQTLVAIDSGANVNFDRLRHV--AER 337
PRK08639 PRK08639
threonine dehydratase; Validated
 7-318 9.38e-37

threonine dehydratase; Validated


Pssm-ID: 236318 [Multi-domain]  Cd Length: 420  Bit Score: 136.86  E-value: 9.38e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   7 ISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGN 86
Cdd:PRK08639   7 VSAKDIDKAAKRLKDVVPETPLQRNDYLSEKYGANVYLKREDLQPVRSYKLRGAYNAISQL---SDEELAAGVVCASAGN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  87 HGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGAS----IVYCDPSDESrEKVTQRIMQETEGILVHPNQEPAVIAG 162
Cdd:PRK08639  84 HAQGVAYACRHLGIPGVIFMPVTTPQQKIDQVRFFGGEfveiVLVGDTFDDS-AAAAQEYAEETGATFIPPFDDPDVIAG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 163 QGTIALEVLNQV---PLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADG 239
Cdd:PRK08639 163 QGTVAVEILEQLekeGSPDYVFVPVGGGGLISGVTTYLKERSPKTKIIGVEPAGAASMKAALEAGKPVT-LEKIDKFVDG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 240 --VKsSIGLNTWPIIRDLVDDVFTVTEDEIkYATQLvwgrmKLL------IEPtAGVALAAVLSQHFQTVspEVKNVCIV 311
Cdd:PRK08639 242 aaVA-RVGDLTFEILKDVVDDVVLVPEGAV-CTTIL-----ELYnkegivAEP-AGALSIAALELYKDEI--KGKTVVCV 311


                 ....*..
gi 254028195 312 LSGGNVD 318
Cdd:PRK08639 312 ISGGNND 318
PRK06110 PRK06110
threonine dehydratase;
8-331 1.55e-30

threonine dehydratase;


Pssm-ID: 235699  Cd Length: 322  Bit Score: 117.79  E-value: 1.55e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   8 SFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTPEekPKAVVTHSSGNH 87
Cdd:PRK06110   4 TLAELEAAAAVVYAAMPPTPQYRWPLLAERLGCEVWVKHENHTPTGAFKVRGGLVYFDRLARRGPR--VRGVISATRGNH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  88 GQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIV-YCDPSDESREKVTQRimQETEGILVHPNQEPAVIAGQGTI 166
Cdd:PRK06110  82 GQSVAFAARRHGLAATIVVPHGNSVEKNAAMRALGAELIeHGEDFQAAREEAARL--AAERGLHMVPSFHPDLVRGVATY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 167 ALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGEL--TPNlhpPETIADGVKSSI 244
Cdd:PRK06110 160 ALELFRAVPDLDVVYVPIGMGSGICGAIAARDALGLKTRIVGVVSAHAPAYALSFEAGRVvtTPV---ATTLADGMACRT 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 245 GL-NTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTvspEVKNVCIVLSGGNVDLTSLN 323
Cdd:PRK06110 237 PDpEALEVIRAGADRIVRVTDDEVAAAMRAYFTDTHNVAEGAGAAALAAALQERERL---AGKRVGLVLSGGNIDRAVFA 313


                 ....*....
gi 254028195 324 -WVGQAERP 331
Cdd:PRK06110 314 rVLAGAAAE 322
PLN02550 PLN02550
threonine dehydratase
 24-325 2.47e-30

threonine dehydratase


Pssm-ID: 178165 [Multi-domain]  Cd Length: 591  Bit Score: 121.18  E-value: 2.47e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  24 HLTPVLTSSI--------------LNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLipdTPEEKPKAVVTHSSGNHGQ 89
Cdd:PLN02550  94 YLTNILSAKVydvaiesplqlakkLSERLGVKVLLKREDLQPVFSFKLRGAYNMMAKL---PKEQLDKGVICSSAGNHAQ 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  90 ALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYC-DPSDESREKVTQRIMQETEgILVHPNQEPAVIAGQGTIAL 168
Cdd:PLN02550 171 GVALSAQRLGCDAVIAMPVTTPEIKWQSVERLGATVVLVgDSYDEAQAYAKQRALEEGR-TFIPPFDHPDVIAGQGTVGM 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 169 EVLNQVP-LVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTpNLHPPETIADGVK-SSIGL 246
Cdd:PLN02550 250 EIVRQHQgPLHAIFVPVGGGGLIAGIAAYVKRVRPEVKIIGVEPSDANAMALSLHHGERV-MLDQVGGFADGVAvKEVGE 328

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254028195 247 NTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVlSQHFQTVSPEVKNVCIVLSGGNVDLTSLNWV 325
Cdd:PLN02550 329 ETFRLCRELVDGVVLVSRDAICASIKDMFEEKRSILEPAGALALAGA-EAYCKYYGLKDENVVAITSGANMNFDRLRIV 406
PRK08813 PRK08813
threonine dehydratase; Provisional
 7-333 4.00e-30

threonine dehydratase; Provisional


Pssm-ID: 236339 [Multi-domain]  Cd Length: 349  Bit Score: 117.42  E-value: 4.00e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   7 ISFADVEKAHINIQDSIHLTPVltssilnQIAGR-NLFFKCELFQKTGSFKIRGALNA-IRGLipDTPEEKPkaVVTHSS 84
Cdd:PRK08813  21 VSVADVLAAQARLRRYLSPTPL-------HYAERfGVWLKLENLQRTGSYKVRGALNAlLAGL--ERGDERP--VICASA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  85 GNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQG 164
Cdd:PRK08813  90 GNHAQGVAWSAYRLGVQAITVMPHGAPQTKIAGVAHWGATVRQHGNSYDEAYAFARELADQNGYRFLSAFDDPDVIAGQG 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 165 TIALEVLNQVPlvDALVVPVGGGGMVAGIAITIKAlkPSVKVYAAEPSNADDCYQSkLKGELTpNLHPPETIADGVKSSI 244
Cdd:PRK08813 170 TVGIELAAHAP--DVVIVPIGGGGLASGVALALKS--QGVRVVGAQVEGVDSMARA-IRGDLR-EIAPVATLADGVKVKI 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 245 -GLNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAvlsqhFQTVSPEVKnvCIVLSGGNVDLTSLN 323
Cdd:PRK08813 244 pGFLTRRLCSSLLDDVVIVREAELRETLVRLALEEHVIAEGAGALALAA-----GRRVSGKRK--CAVVSGGNIDATVLA 316

                        330
                 ....*....|
gi 254028195 324 WVGQAERPAP 333
Cdd:PRK08813 317 TLLSEVRPRP 326
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
 26-294 3.67e-26

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 105.29  E-value: 3.67e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLI-PDTpeekpkAVVTHSSGNHGQALTYAAKLEG 99
Cdd:cd01561    3 TPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIedaekRGLLkPGT------TIIEPTSGNTGIGLAMVAAAKG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 100 IPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSD----ESREKVTQRIMQETEGIlVHPNQ--EPA-VIAGQGTIALEVLN 172
Cdd:cd01561   77 YRFIIVMPETMSEEKRKLLRALGAEVILTPEAEadgmKGAIAKARELAAETPNA-FWLNQfeNPAnPEAHYETTAPEIWE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 173 QVP-LVDALvvpvggggmvagIA-------IT-----IKALKPSVKVYAAEPSNADdcyqsklkgeLTPNLHPPETIADG 239
Cdd:cd01561  156 QLDgKVDAF------------VAgvgtggtITgvaryLKEKNPNVRIVGVDPVGSV----------LFSGGPPGPHKIEG 213

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 254028195 240 vkssIGLNTWPII--RDLVDDVFTVTEDE-IKYATQLVwGRMKLLIEPTAGVALAAVL 294
Cdd:cd01561  214 ----IGAGFIPENldRSLIDEVVRVSDEEaFAMARRLA-REEGLLVGGSSGAAVAAAL 266
L-Ser-dehyd cd06448
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ...
 26-316 2.81e-23

Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.


Pssm-ID: 107209  Cd Length: 316  Bit Score: 98.14  E-value: 2.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIpDTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIV 105
Cdd:cd06448    2 TPLIESTALSKTAGCNVFLKLENLQPSGSFKIRGIGHLCQKSA-KQGLNECVHVVCSSGGNAGLAAAYAARKLGVPCTIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 106 VPQTAPNCKKLAIQAYGASIV-----YCDPSDESREKVTQRimqETEGILVHPNQEPAVIAGQGTIALEVLNQVPL---V 177
Cdd:cd06448   81 VPESTKPRVVEKLRDEGATVVvhgkvWWEADNYLREELAEN---DPGPVYVHPFDDPLIWEGHSSMVDEIAQQLQSqekV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 178 DALVVPVGGGGMVAGIAITI-KALKPSVKVYAAEPSNADDCYQSKLKGELTPnLHPPETIADGVKSS-IGLNTW------ 249
Cdd:cd06448  158 DAIVCSVGGGGLLNGIVQGLeRNGWGDIPVVAVETEGAHSLNASLKAGKLVT-LPKITSVATSLGAKtVSSQALeyaqeh 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254028195 250 PIIRDLVDD------VFTVTEDEikyatqlvwgrmKLLIEPTAGVALAAVLSQHFQTVSPEVK-----NVCIVLSGGN 316
Cdd:cd06448  237 NIKSEVVSDrdavqaCLRFADDE------------RILVEPACGAALAVVYSGKILDLQLEVLltpldNVVVVVCGGS 302
ThrC COG0498
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ...
 26-294 1.11e-22

Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 440264 [Multi-domain]  Cd Length: 394  Bit Score: 97.58  E-value: 1.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  26 TPVLTSSILNQIAGRNLFFKcELFQ-KTGSFKIRG---ALNAIRglipdtpEEKPKAVVTHSSGNHGQAL-TYAAKlEGI 100
Cdd:COG0498   67 TPLVKAPRLADELGKNLYVK-EEGHnPTGSFKDRAmqvAVSLAL-------ERGAKTIVCASSGNGSAALaAYAAR-AGI 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 101 PAYIVVPQT-APNCKKLAIQAYGASIVYCDPS-DEsREKVTQRIMQETEGILVHpNQEPAVIAGQGTIALEV---LNQVP 175
Cdd:COG0498  138 EVFVFVPEGkVSPGQLAQMLTYGAHVIAVDGNfDD-AQRLVKELAADEGLYAVN-SINPARLEGQKTYAFEIaeqLGRVP 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 176 lvDAlvvpvggggmvagiaITI------------KALK-----------PsvKVYAAEPSNADDCYQSKLKGELTPNLHP 232
Cdd:COG0498  216 --DW---------------VVVptgnggnilagyKAFKelkelglidrlP--RLIAVQATGCNPILTAFETGRDEYEPER 276

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254028195 233 PETIADGVksSIG--LNTWPIIRDLVD---DVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVL 294
Cdd:COG0498  277 PETIAPSM--DIGnpSNGERALFALREsggTAVAVSDEEILEAIRLLARREGIFVEPATAVAVAGLR 341
Thr-synth_1 cd01563
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ...
 26-311 6.20e-21

Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.


Pssm-ID: 107206 [Multi-domain]  Cd Length: 324  Bit Score: 91.50  E-value: 6.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  26 TPVLTSSILNQIAG-RNLFFKCELFQKTGSFKIRGALNAIRGLIpdtpEEKPKAVVTHSSGNHGQAL-TYAAKlEGIPAY 103
Cdd:cd01563   23 TPLVRAPRLGERLGgKNLYVKDEGLNPTGSFKDRGMTVAVSKAK----ELGVKAVACASTGNTSASLaAYAAR-AGIKCV 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 104 IVVPQTAPNCKKLAIQAYGASIVycdPSDESRE---KVTQRIMQETEGILVHpNQEPAVIAGQGTIALEVLNQ----VPl 176
Cdd:cd01563   98 VFLPAGKALGKLAQALAYGATVL---AVEGNFDdalRLVRELAEENWIYLSN-SLNPYRLEGQKTIAFEIAEQlgweVP- 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 177 vDALVVPVGGGGMVAGIAITIKALKPS------VKVYAAEPSNADDCYQSKLKG--ELTPNLHpPETIADGVKssIGlN- 247
Cdd:cd01563  173 -DYVVVPVGNGGNITAIWKGFKELKELglidrlPRMVGVQAEGAAPIVRAFKEGkdDIEPVEN-PETIATAIR--IG-Np 247

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 248 -TWPIIRDLVD----DVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQ-TVSPEVKNVCIV 311
Cdd:cd01563  248 aSGPKALRAVResggTAVAVSDEEILEAQKLLARTEGIFVEPASAASLAGLKKLREEgIIDKGERVVVVL 317
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
 18-294 9.90e-21

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 90.49  E-value: 9.90e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  18 NIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLI-PDTPeekpkaVVTHSSGNHGQAL 91
Cdd:COG0031    6 SILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIedaekRGLLkPGGT------IVEATSGNTGIGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  92 TYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSD--ESREKVTQRIMQETEGIlVHPNQ--EPA-VIAGQGTI 166
Cdd:COG0031   80 AMVAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEgmKGAIDKAEELAAETPGA-FWPNQfeNPAnPEAHYETT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 167 ALEVLNQVPL-VDALvvpvggggmvagIA-------IT-----IKALKPSVKVYAAEPSNAddcyqSKLKGElTPNLHPP 233
Cdd:COG0031  159 GPEIWEQTDGkVDAF------------VAgvgtggtITgvgryLKERNPDIKIVAVEPEGS-----PLLSGG-EPGPHKI 220

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254028195 234 ETIADGVKSSIglntwpIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVL 294
Cdd:COG0031  221 EGIGAGFVPKI------LDPSLIDEVITVSDEEAFAMARRLAREEGILVGISSGAAVAAAL 275
thrC TIGR00260
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ...
 33-318 1.89e-15

threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 272986 [Multi-domain]  Cd Length: 327  Bit Score: 75.88  E-value: 1.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195   33 ILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIpdtpEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPN 112
Cdd:TIGR00260  31 LAANVGIKNLYVKELGHNPTLSFKDRGMAVALTKAL----ELGNDTVLCASTGNTGAAAAAYAGKAGLKVVVLYPAGKIS 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  113 CKKLAIQ-AYGASIVYCDPS-DESREKVTQrIMQETEGILVHP-NQEPAVIAGQGTIALEVLNQVP--LVDALVVPVGGG 187
Cdd:TIGR00260 107 LGKLAQAlGYNAEVVAIDGNfDDAQRLVKQ-LFEDKPALGLNSaNSIPYRLEGQKTYAFEAVEQLGweAPDKVVVPVPNS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  188 GMVAGIAITIKALK-------PsvKVYAAEPSNADDCYQSKLK-GELTPNLHPpETIA---DGVKSSIGLNTWPIIRDLV 256
Cdd:TIGR00260 186 GNFGAIWKGFKEKKmlgldslP--VKRGIQAEGAADIVRAFLEgGQWEPIETP-ETLStamDIGNPANWPRALEAFRRSN 262

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254028195  257 DDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQ-TVSPEVKNVCIVLSGGNVD 318
Cdd:TIGR00260 263 GYAEDLSDEEILEAIKLLAREEGYFVEPHSAVAVAALLKLVEKgTADPAERVVCALTGNGLKD 325
PRK08329 PRK08329
threonine synthase; Validated
 24-319 4.83e-14

threonine synthase; Validated


Pssm-ID: 236244 [Multi-domain]  Cd Length: 347  Bit Score: 72.17  E-value: 4.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  24 HLTPVLTSSILNqiaGRNLFFKCELFQKTGSFKIRGALNAIRGLipdtPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAY 103
Cdd:PRK08329  59 HLTPPITPTVKR---SIKVYFKLDYLQPTGSFKDRGTYVTVAKL----KEEGINEVVIDSSGNAALSLALYSLSEGIKVH 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 104 IVVPQTAPNCKKLAIQAYGASIVYCDpsdESREKVTQRIMQ--ETEGIL-VHPNQEPAVIAGQGTIALEVLNQVPLVDAL 180
Cdd:PRK08329 132 VFVSYNASKEKISLLSRLGAELHFVE---GDRMEVHEEAVKfsKRNNIPyVSHWLNPYFLEGTKTIAYEIYEQIGVPDYA 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 181 VVPVGGGGMVAGIAITIKALK--------PSVKVYAAEPSNAdDCYQSKLKGELT-----PNlhPP--ETIADGVKSSIG 245
Cdd:PRK08329 209 FVPVGSGTLFLGIWKGFKELHemgeiskmPKLVAVQAEGYES-LCKRSKSENKLAdgiaiPE--PPrkEEMLRALEESNG 285

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254028195 246 LntwpiirdlvddVFTVTEDEIKYAtqLVW-GRMKLLIEPTAGVALAAVLSQHFQTVSPEVKNVCIVLSGGNVDL 319
Cdd:PRK08329 286 F------------CISVGEEETRAA--LHWlRRMGFLVEPTSAVALAAYWKLLEEGLIEGGSKVLLPLSGSGLKN 346
PRK05638 PRK05638
threonine synthase; Validated
 26-314 1.68e-13

threonine synthase; Validated


Pssm-ID: 235539 [Multi-domain]  Cd Length: 442  Bit Score: 71.00  E-value: 1.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  26 TPVLTSSILNQIaGRNLFFKCELFQKTGSFKIRGALNAIRGLIPdtpeEKPKAVVTHSSGNHGQALT-YAAKlEGIPAYI 104
Cdd:PRK05638  67 TPLIRARISEKL-GENVYIKDETRNPTGSFRDRLATVAVSYGLP----YAANGFIVASDGNAAASVAaYSAR-AGKEAFV 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 105 VVPQTAPNCKKLAIQAYGAS-IVYCDPSDESREKVTQRimQETEGIL-VHPNQEPAVIAGQGTIALEVLNQ-------VP 175
Cdd:PRK05638 141 VVPRKVDKGKLIQMIAFGAKiIRYGESVDEAIEYAEEL--ARLNGLYnVTPEYNIIGLEGQKTIAFELWEEinpthviVP 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 176 LVDALVVPVGGGGMVAGIAITIKALKPsvKVYAAEPSNADDCYQSKL--KGELTPNLHPPETIADGVKSSIGLNtwpIIR 253
Cdd:PRK05638 219 TGSGSYLYSIYKGFKELLEIGVIEEIP--KLIAVQTERCNPIASEILgnKTKCNETKALGLYVKNPVMKEYVSE---AIK 293

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254028195 254 DLVDDVFTVTEDEIKYATQLVwgrMK--LLIEPTAGVALAAVLSQHFQTVSPEVKNVCIVLSG 314
Cdd:PRK05638 294 ESGGTAVVVNEEEIMAGEKLL---AKegIFAELSSAVVMPALLKLGEEGYIEKGDKVVLVVTG 353
PRK06450 PRK06450
threonine synthase; Validated
 37-314 3.36e-11

threonine synthase; Validated


Pssm-ID: 180565 [Multi-domain]  Cd Length: 338  Bit Score: 63.60  E-value: 3.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  37 IAGRNLFFKCELFQKTGSFKIRGAlnaiRGLIPDTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKL 116
Cdd:PRK06450  62 IKKGNIWFKLDFLNPTGSYKDRGS----VTLISYLAEKGIKQISEDSSGNAGASIAAYGAAAGIEVKIFVPETASGGKLK 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 117 AIQAYGASIVYCdpsDESREKVtQRIMQETEGILVHPNQEPAVIAGQGTIALEVLNQ----------VPlVDA------- 179
Cdd:PRK06450 138 QIESYGAEVVRV---RGSREDV-AKAAENSGYYYASHVLQPQFRDGIRTLAYEIAKDldwkipnyvfIP-VSAgtlllgv 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 180 ------LVVPVGGGGMVAGIAITIKALKPsvkVYAaepsnaddcyqsKLKGEltpNLHPPE---TIADGVKSsiglnTWP 250
Cdd:PRK06450 213 ysgfkhLLDSGVISEMPKIVAVQTEQVSP---LCA------------KFKGI---SYTPPDkvtSIADALVS-----TRP 269

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254028195 251 IIRDLVDDVF-------TVTEDEIKYATQLVwGRMKLLIEPTAGVALAAvlsqhFQTVSPEvkNVCIVLSG 314
Cdd:PRK06450 270 FLLDYMVKALseygeciVVSDNEIVEAWKEL-AKKGLLVEYSSATVYAA-----YKKYSVN--DSVLVLTG 332
PRK08197 PRK08197
threonine synthase; Validated
 25-173 2.43e-09

threonine synthase; Validated


Pssm-ID: 181283 [Multi-domain]  Cd Length: 394  Bit Score: 58.09  E-value: 2.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  25 LTPVLTSSIL-NQIAGRNLFFKCELFQKTGSFKIRGALNAI-RGlipdtPEEKPKAVVTHSSGNHGQAL-TYAAKLeGIP 101
Cdd:PRK08197  79 MTPLLPLPRLgKALGIGRLWVKDEGLNPTGSFKARGLAVGVsRA-----KELGVKHLAMPTNGNAGAAWaAYAARA-GIR 152

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254028195 102 AYIVVPQTAPNCKKLAIQAYGASIVYCDP--SDESReKVTQRImqETEGIL-VHPNQEPAVIAGQGTIALEVLNQ 173
Cdd:PRK08197 153 ATIFMPADAPEITRLECALAGAELYLVDGliSDAGK-IVAEAV--AEYGWFdVSTLKEPYRIEGKKTMGLELAEQ 224
PRK06381 PRK06381
threonine synthase; Validated
 26-133 3.05e-09

threonine synthase; Validated


Pssm-ID: 235789  Cd Length: 319  Bit Score: 57.41  E-value: 3.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  26 TPVLTSSILNQIAG-RNLFFKCELFQKTGSFKIRGALNAIRGLIpdtpEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYI 104
Cdd:PRK06381  16 TPLLRARKLEEELGlRKIYLKFEGANPTGTQKDRIAEAHVRRAM----RLGYSGITVGTCGNYGASIAYFARLYGLKAVI 91

                         90       100
                 ....*....|....*....|....*....
gi 254028195 105 VVPQTAPNCKKLAIQAYGASIVYCDPSDE 133
Cdd:PRK06381  92 FIPRSYSNSRVKEMEKYGAEIIYVDGKYE 120
PRK08206 PRK08206
diaminopropionate ammonia-lyase; Provisional
 53-287 3.30e-08

diaminopropionate ammonia-lyase; Provisional


Pssm-ID: 236186  Cd Length: 399  Bit Score: 54.50  E-value: 3.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  53 GSFKIRGALNAIRGLIPD---------------TPEEKPKA----VVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNC 113
Cdd:PRK08206  74 NAFKALGGAYAVARLLAEklgldiselsfeeltSGEVREKLgditFATATDGNHGRGVAWAAQQLGQKAVIYMPKGSSEE 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 114 KKLAIQAYGASIVYCDPS-DES-REkvTQRIMQETEGILVhpnQEPA----------VIAGQGTIALEVLNQVPlvdalv 181
Cdd:PRK08206 154 RVDAIRALGAECIITDGNyDDSvRL--AAQEAQENGWVVV---QDTAwegyeeiptwIMQGYGTMADEAVEQLK------ 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 182 vpvggggmVAGIAIT-------IKALKPSV-----KVYAA--------EPSNADDCYQSKLKGELTPNLHPPETI----A 237
Cdd:PRK08206 223 --------EMGVPPThvflqagVGSLAGAVlgyfaEVYGEqrphfvvvEPDQADCLYQSAVDGKPVAVTGDMDTImaglA 294

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 254028195 238 DGVKSSIGlntWPIIRDLVDDVFTVTEDEIKYAtqlvwgrMKLLIEPTAG 287
Cdd:PRK08206 295 CGEPNPLA---WEILRNCADAFISCPDEVAALG-------MRILANPLGG 334
PRK10717 PRK10717
cysteine synthase A; Provisional
 18-274 6.64e-06

cysteine synthase A; Provisional


Pssm-ID: 182672 [Multi-domain]  Cd Length: 330  Bit Score: 47.16  E-value: 6.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  18 NIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLIpdtpeeKP-KAVVTHSSGNHGQAL 91
Cdd:PRK10717   6 DVSDTIGNTPLIRLNRASEATGCEILGKAEFLNPGGSVKDRAALNIIwdaekRGLL------KPgGTIVEGTAGNTGIGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  92 TYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIV------YCDPSDesREKVTQRIMQEtegiLVHPNQEPAVIAGQ-- 163
Cdd:PRK10717  80 ALVAAARGYKTVIVMPETQSQEKKDLLRALGAELVlvpaapYANPNN--YVKGAGRLAEE----LVASEPNGAIWANQfd 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 164 ---------GTIALEVLNQVP-LVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNAdDCYQSKLKGELTPnlhPP 233
Cdd:PRK10717 154 npanreahyETTGPEIWEQTDgKVDGFVCAVGTGGTLAGVSRYLKETNPKVKIVLADPTGS-ALYSYYKTGELKA---EG 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 254028195 234 ETIADGvkssIGLN--TWPIIRDLVDDVFTVTEDE-IKYATQLV 274
Cdd:PRK10717 230 SSITEG----IGQGriTANLEGAPIDDAIRIPDEEaLSTAYRLL 269
PLN02556 PLN02556
cysteine synthase/L-3-cyanoalanine synthase
 26-273 2.09e-04

cysteine synthase/L-3-cyanoalanine synthase


Pssm-ID: 178171 [Multi-domain]  Cd Length: 368  Bit Score: 42.64  E-value: 2.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  26 TPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLIpdTPEEKpkAVVTHSSGNHGQALTYAAKLEGI 100
Cdd:PLN02556  60 TPLVYLNKVTEGCGAYIAAKQEMFQPTSSIKDRPALAMIedaekKNLI--TPGKT--TLIEPTSGNMGISLAFMAAMKGY 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 101 PAYIVVPQTAPNCKKLAIQAYGASIVYCDPSD---ESREKVTQRIMQETEGILVHPNQEPA-VIAGQGTIALEVL-NQVP 175
Cdd:PLN02556 136 KMILTMPSYTSLERRVTMRAFGAELVLTDPTKgmgGTVKKAYELLESTPDAFMLQQFSNPAnTQVHFETTGPEIWeDTLG 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 176 LVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKlkgeltPNLHPPETIADGVKSSIglntwpIIRDL 255
Cdd:PLN02556 216 QVDIFVMGIGSGGTVSGVGKYLKSKNPNVKIYGVEPAESNVLNGGK------PGPHHITGNGVGFKPDI------LDMDV 283

                        250
                 ....*....|....*....
gi 254028195 256 VDDVFTVT-EDEIKYATQL 273
Cdd:PLN02556 284 MEKVLEVSsEDAVNMAREL 302
cysM PRK11761
cysteine synthase CysM;
19-150 3.20e-04

cysteine synthase CysM;


Pssm-ID: 236972  Cd Length: 296  Bit Score: 41.78  E-value: 3.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  19 IQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAI-----RGLIpdtpeeKPKAV-VTHSSGNHGQALT 92
Cdd:PRK11761   6 LEDTIGNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMIvqaekRGEI------KPGDTlIEATSGNTGIALA 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254028195  93 YAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCdPSDESRE---KVTQRIMQETEGIL 150
Cdd:PRK11761  80 MIAAIKGYRMKLIMPENMSQERRAAMRAYGAELILV-PKEQGMEgarDLALQMQAEGEGKV 139
PLN02565 PLN02565
cysteine synthase
 45-294 5.24e-04

cysteine synthase


Pssm-ID: 166206  Cd Length: 322  Bit Score: 41.45  E-value: 5.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  45 KCELFQKTGSFKIRGALNAI-----RGLIpdTPEEKpkAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQ 119
Cdd:PLN02565  35 KLEMMEPCSSVKDRIGYSMItdaeeKGLI--KPGES--VLIEPTSGNTGIGLAFMAAAKGYKLIITMPASMSLERRIILL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 120 AYGASIVYCDPSDESREKVtqrimQETEGILVH-PN----QE---------------PAVIAGQGTialevlnqvpLVDA 179
Cdd:PLN02565 111 AFGAELVLTDPAKGMKGAV-----QKAEEILAKtPNsyilQQfenpanpkihyettgPEIWKGTGG----------KVDA 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 180 LVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSnaddcyQSKLKGELTPNLHPPETIADGVKSSIgLNTwpiirDLVDDV 259
Cdd:PLN02565 176 FVSGIGTGGTITGAGKYLKEQNPDIKLYGVEPV------ESAVLSGGKPGPHKIQGIGAGFIPGV-LDV-----DLLDEV 243

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 254028195 260 FTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVL 294
Cdd:PLN02565 244 VQVSSDEAIETAKLLALKEGLLVGISSGAAAAAAI 278
PLN02356 PLN02356
phosphateglycerate kinase
 21-130 9.10e-04

phosphateglycerate kinase


Pssm-ID: 215204  Cd Length: 423  Bit Score: 40.74  E-value: 9.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  21 DSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIpDTPEEKPKAVVTH-SSGNHGQALTYAAKLEG 99
Cdd:PLN02356  49 DAIGNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKIIEEAL-ESGQLFPGGVVTEgSAGSTAISLATVAPAYG 127

                         90       100       110
                 ....*....|....*....|....*....|.
gi 254028195 100 IPAYIVVPQTAPNCKKLAIQAYGASIVYCDP 130
Cdd:PLN02356 128 CKCHVVIPDDVAIEKSQILEALGATVERVRP 158
PLN02569 PLN02569
threonine synthase
 36-173 3.64e-03

threonine synthase


Pssm-ID: 178182 [Multi-domain]  Cd Length: 484  Bit Score: 39.03  E-value: 3.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  36 QIAGRN-LFFKCELFQKTGSFKIRG------ALNAIRGLipdtpeEKP-KAVVTHSSGNHGQALTYAAKLEGIPAYIVVP 107
Cdd:PLN02569 145 EFLGMNdLWVKHCGISHTGSFKDLGmtvlvsQVNRLRKM------AKPvVGVGCASTGDTSAALSAYCAAAGIPSIVFLP 218

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254028195 108 QTAPNCKKLaIQ--AYGASIVYCDPSDESREKVTQRIMQETEgILVHPNQEPAVIAGQGTIALEVLNQ 173
Cdd:PLN02569 219 ADKISIAQL-VQpiANGALVLSIDTDFDGCMRLIREVTAELP-IYLANSLNSLRLEGQKTAAIEILQQ 284
PLN00011 PLN00011
cysteine synthase
 45-294 4.68e-03

cysteine synthase


Pssm-ID: 177651  Cd Length: 323  Bit Score: 38.45  E-value: 4.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195  45 KCELFQKTGSFKIRGALNAIR-----GLIpdTPEEKpkAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQ 119
Cdd:PLN00011  37 KLEMMEPCSSVKDRIAYSMIKdaedkGLI--TPGKS--TLIEATAGNTGIGLACIGAARGYKVILVMPSTMSLERRIILR 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 120 AYGASIVYCDPSDESR---EKVTQRIMQETEGILVHPNQEPAVIAGQ-GTIALEVL-NQVPLVDALVVPVGGGGMVAGIA 194
Cdd:PLN00011 113 ALGAEVHLTDQSIGLKgmlEKAEEILSKTPGGYIPQQFENPANPEIHyRTTGPEIWrDSAGKVDILVAGVGTGGTATGVG 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254028195 195 ITIKALKPSVKVYAAEPSnaddcyQSKLKGELTPNLHPPETIADG-VKSSIGLNtwpiirdLVDDVFTVTEDEIKYATQL 273
Cdd:PLN00011 193 KFLKEKNKDIKVCVVEPV------ESAVLSGGQPGPHLIQGIGSGiIPFNLDLT-------IVDEIIQVTGEEAIETAKL 259

                        250       260
                 ....*....|....*....|.
gi 254028195 274 VWGRMKLLIEPTAGVALAAVL 294
Cdd:PLN00011 260 LALKEGLLVGISSGAAAAAAL 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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